MCID: AGG001
MIFTS: 50

Aggressive Periodontitis

Categories: Bone diseases, Genetic diseases, Oral diseases

Aliases & Classifications for Aggressive Periodontitis

MalaCards integrated aliases for Aggressive Periodontitis:

Name: Aggressive Periodontitis 12 43 15 17
Periodontitis, Juvenile 71
Juvenile Periodontitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1474
MeSH 43 D010520
SNOMED-CT 67 449908004
ICD10 32 K05.2
UMLS 71 C0031106

Summaries for Aggressive Periodontitis

Disease Ontology : 12 A periodontitis that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as dental plaque and dental calculus resulting in inflammation and a loss of periodontium.

MalaCards based summary : Aggressive Periodontitis, also known as periodontitis, juvenile, is related to periodontitis, aggressive, 1 and periodontitis, chronic. An important gene associated with Aggressive Periodontitis is PDON2 (Periodontitis, Localized Aggressive), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Chlorhexidine and sodium fluoride have been mentioned in the context of this disorder. Affiliated tissues include bone, neutrophil and monocytes, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 74 Aggressive periodontitis describes a type of periodontal disease and includes two of the seven... more...

Related Diseases for Aggressive Periodontitis

Diseases in the Aggressive Periodontitis family:

Periodontitis, Aggressive, 1 Periodontitis, Aggressive, 2

Diseases related to Aggressive Periodontitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 686)
# Related Disease Score Top Affiliating Genes
1 periodontitis, aggressive, 1 33.1 MMP8 IL1A FPR1 CTSC
2 periodontitis, chronic 32.5 TNFSF11 TNFRSF11B MMP8 IL6 IL1B
3 gingival recession 31.4 MMP8 IL6 IL1B
4 juvenile arthritis 30.9 IL6 IL10 CXCL8
5 gingival overgrowth 30.7 TNF MMP8 IL6 IL1A CXCL8
6 periodontosis 30.5 GLT6D1 CTSC
7 juvenile rheumatoid arthritis 30.4 TNF IL6 IL1RN IL1B IL10 CXCL8
8 histiocytosis 30.4 TNFSF11 TNF IL1RN
9 pyoderma gangrenosum 30.3 TNF IL1RN CXCL8
10 cutaneous lupus erythematosus 30.3 TNF IL6 IL1B IL10
11 tetanus 30.3 TNF IL6 IL4 IL1B IL1A IL10
12 alopecia 30.3 VDR TNF IL4 IL1B
13 pyoderma 30.3 TNF IL1RN IL1B CXCL8
14 mental depression 30.3 TNF IL6 IL1B
15 infective endocarditis 30.3 TNF TLR2 IL6 FCGR2A
16 sarcoidosis 1 30.3 TNF IL1RN IL1B IL1A
17 bone resorption disease 30.2 VDR TNFSF11 TNFRSF11B TNF IL6 IL1B
18 gingivitis 30.1 TNF TLR2 MMP8 IL6 IL4 IL1B
19 herpes zoster 30.0 TNF TLR2 IL10 FCGR2A
20 spondylitis 30.0 TNFSF11 TNF IL6 IL1RN IL10
21 ankylosis 29.9 TNFSF11 TNFRSF11B TNF
22 common variable immunodeficiency 29.6 TNF TLR2 IL6 IL4 IL1B IL1A
23 spondyloarthropathy 29.5 TNFSF11 TNF IL6 IL4 IL1B IL10
24 spondyloarthropathy 1 29.5 TNFSF11 TNFRSF11B TNF TLR4 IL1RN
25 cardiovascular system disease 29.5 VDR TNFRSF11B TNF TLR4 IL6
26 endocarditis 29.5 TNF TLR2 IL6 IL1A IL10 FCGR2A
27 crohn's disease 29.4 TNF TLR4 TLR2 IL6 IL4 IL1B
28 root resorption 29.3 VDR TNFSF11 TNFRSF11B IL6 IL4 IL1RN
29 body mass index quantitative trait locus 11 29.1 TNF TLR4 TLR2 IL6 IL4 IL1B
30 proteasome-associated autoinflammatory syndrome 1 29.1 TNF TLR4 TLR2 IL6 IL4 IL1RN
31 autoimmune disease 29.0 VDR TNF IL6 IL4 IL1RN IL1B
32 diabetes mellitus, type i 28.8 VDR TNF TLR4 TLR2 IL6 IL4
33 arthritis 28.6 TNFSF11 TNF TLR4 TLR2 MMP8 IL6
34 bacterial infectious disease 28.4 TNF TLR4 TLR2 IL6 IL1RN IL1B
35 periodontitis 28.4 VDR TNFSF11 TNFRSF11B TNF TLR4 TLR2
36 inflammatory bowel disease 28.0 VDR TNF TLR4 TLR2 IL6 IL4
37 susceptibility to localized juvenile periodontitis 12.5
38 papillon-lefevre syndrome 11.6
39 physiological polycythemia 10.7 TNF IL1B
40 punctate inner choroidopathy 10.6 TNF IL10
41 external pathological resorption 10.6 TNF IL6
42 scorpion envenomation 10.6 TNF IL6
43 staphylococcal toxic shock syndrome 10.6 TNF IL1B
44 multifocal choroiditis 10.6 TNF IL10
45 systemic onset juvenile idiopathic arthritis 10.6 TNF IL1RN IL1B
46 palladium allergic contact dermatitis 10.6 TNF IL1B IL10
47 vulvar vestibulitis syndrome 10.6 TNF IL1RN IL1B
48 spotted fever rickettsiosis 10.6 TNF IL10
49 meningococcemia 10.6 IL1RN IL1B IL1A
50 anaerobic pneumonia 10.5 TNF IL6 IL1B

Graphical network of the top 20 diseases related to Aggressive Periodontitis:



Diseases related to Aggressive Periodontitis

Symptoms & Phenotypes for Aggressive Periodontitis

MGI Mouse Phenotypes related to Aggressive Periodontitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.24 CTSC FCGR2A FPR1 IL10 IL1A IL1B
2 homeostasis/metabolism MP:0005376 10.17 CTSC FPR1 IL10 IL1A IL1B IL1RN
3 immune system MP:0005387 10.16 CTSC FCGR2A FPR1 IL10 IL1A IL1B
4 cardiovascular system MP:0005385 10.13 IL10 IL1A IL1B IL1RN IL6 TLR2
5 craniofacial MP:0005382 9.95 IL10 IL1B IL4 TNF TNFRSF11B TNFSF11
6 integument MP:0010771 9.93 CTSC IL10 IL1A IL1B IL1RN IL4
7 neoplasm MP:0002006 9.61 IL10 IL1A IL1B IL6 MMP8 TLR2
8 skeleton MP:0005390 9.4 FCGR2A IL10 IL1B IL1RN IL4 IL6

Drugs & Therapeutics for Aggressive Periodontitis

Drugs for Aggressive Periodontitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 66)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
2 sodium fluoride Approved Phase 4 7681-49-4
3
Triclosan Approved, Investigational Phase 4 3380-34-5 5564
4
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
5
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
6
Metronidazole Approved Phase 4 443-48-1 4173
7
Phenothiazine Experimental, Vet_approved Phase 4 92-84-2
8 Chlorhexidine gluconate Phase 4
9 Antiparasitic Agents Phase 4
10 Antiprotozoal Agents Phase 4
11 Hypolipidemic Agents Phase 4
12 Anti-Infective Agents, Local Phase 4
13 Protective Agents Phase 4
14 Lipid Regulating Agents Phase 4
15 Listerine Phase 4
16 Antimetabolites Phase 4
17 Anesthetics, Local Phase 4
18 Norgestimate, ethinyl estradiol drug combination Phase 4
19 Antibiotics, Antitubercular Phase 4
20
Clarithromycin Approved Phase 2, Phase 3 81103-11-9 84029
21
Clindamycin Approved, Vet_approved Phase 3 18323-44-9 29029
22
Aspirin Approved, Vet_approved Phase 2, Phase 3 50-78-2 2244
23 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3
24 Cytochrome P-450 CYP3A Inhibitors Phase 2, Phase 3
25 Clindamycin phosphate Phase 3
26 Clindamycin palmitate Phase 3
27 Fibrinolytic Agents Phase 2, Phase 3
28 Analgesics, Non-Narcotic Phase 2, Phase 3
29 Analgesics Phase 2, Phase 3
30 Omega 3 Fatty Acid Phase 2, Phase 3
31 Platelet Aggregation Inhibitors Phase 2, Phase 3
32 Cyclooxygenase Inhibitors Phase 2, Phase 3
33 Antipyretics Phase 2, Phase 3
34 Antirheumatic Agents Phase 2, Phase 3
35 Anti-Inflammatory Agents Phase 2, Phase 3
36 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
37
Doxycycline Approved, Investigational, Vet_approved Phase 1, Phase 2 564-25-0 54671203
38 Antimalarials Phase 1, Phase 2
39
Lidocaine Approved, Vet_approved 137-58-6 3676
40
Epinephrine Approved, Vet_approved 51-43-4 5816
41
Racepinephrine Approved 329-65-7 838
42
Nitric Oxide Approved 10102-43-9 145068
43
Dinoprostone Approved 363-24-6 5280360
44
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
45
Erythritol Experimental 149-32-6, 2418-52-2 169019
46 Epinephryl borate
47 Trace Elements
48 Vitamins
49 Nutrients
50 Dihydroxycholecalciferols

Interventional clinical trials:

(show top 50) (show all 62)
# Name Status NCT ID Phase Drugs
1 Adjunctive Systemic Administration of Moxifloxacin in the Treatment of Aggressive Periodontitis: Double-blind Controlled Clinical Trial Completed NCT02125812 Phase 4
2 Efficacy of β-glucan in Treatment of Localized Aggressive Periodontitis: A Short Term Double-blinded, Placebo-controlled, Randomized Clinical Trial Completed NCT02402296 Phase 4 β-1,3/1,6-D-glucan
3 Evaluation of Gingival Crevicular Fluid Interleukin-1β and Interleukin-17 Levels and Periodontal Pathogens After Full-Mouth Disinfection Initial Periodontal Treatment in Generalized Aggressive Periodontitis Patients Completed NCT02466646 Phase 4 Klorhex® Gel, rinse and spray
4 The Use of Amoxicillin and Metronidazole in Association With Non-surgical Therapy in Aggressive Periodontitis Treatment Completed NCT03933501 Phase 4 amoxicillin and metronidazole;Placebos
5 Triclosan as Adjunctive Therapy in the Plaque Control in Children From Generalized Aggressive Periodontitis Families. A Controlled and Randomized Clinical Trial. Completed NCT03642353 Phase 4 Triclosan;Placebo
6 Antimicrobial Therapy as Adjunct to Periodontal Treatment: Effect of Timing on Clinical, Microbiological and Systemic Response Completed NCT02197260 Phase 4 3/d 500 mg metronidazole plus 375 mg amoxicillin for 7 days
7 Clinical Evaluation of Systemic Moxifloxacin Compared to Amoxicillin Plus Metronidazole Adjunct to Non-surgical Treatment in Generalized Aggressive Periodontitis: A Randomized Clinical Trial Completed NCT02223702 Phase 4 Amoxicillin;Metronidazole;Moxifloxacin
8 Clinical, Microbiological and Immunological Effects of Antimicrobial Photodynamic Therapy on Non-surgical Treatment of Aggressive Periodontitis: a Double-blind Split-mouth Randomized Controlled Clinical Trial. Completed NCT02049008 Phase 4
9 Enamel Matrix Proteins in the Treatment of Intrabony Defects in Patients With Aggressive and Chronic Periodontitis: Randomized Clinical Trial Completed NCT03025204 Phase 4
10 Amnion-Chorion Allograft Barrier Used for Root Surface and Guided Tissue Regeneration for Periodontal Intrabony Defects and Grade II Furcation Defects. Recruiting NCT03095976 Phase 4
11 Efficacy of Moxifloxacin, Amoxicillin+Metronidazole for Aggressive Periodontitis Treatment Active, not recruiting NCT02839421 Phase 4 Scaling and Root Planing combined with moxifloxacin
12 Full-mouth Periodontal Debridement Associated With Two Different Antibiotic Agents to Treat Generalized Aggressive Periodontitis: Randomized Controlled Clinical Trial Completed NCT02969928 Phase 2, Phase 3 Clarithromycin;Amoxicillin;Metronidazole
13 Local Effect of Periodontal Debridement Associated With Different Systemic Antibiotic Protocols and Single or Repeated Application of Photodynamic Therapy to Treat Generalized Aggressive Periodontitis: Randomized Controlled Clinical Trial Completed NCT03132714 Phase 2, Phase 3 Amoxicillin 500mg;Metronidazole 400mg;Clarithromycin 500mg
14 Evaluation of Omega-3 Polyunsaturated Fatty Acids Plus Low-dose Aspirin Daily Supplementation in Non-surgical Therapy to Treat Generalized Aggressive Periodontitis: Randomized Controlled Clinical Trial Completed NCT03093246 Phase 2, Phase 3 Aspirin
15 Efficacy of Amoxicillin-metronidazole Compared to Clindamycin in the Treatment of Periodontitis in Patients With Diabetes Completed NCT03374176 Phase 3 Amoxicillin 500 mg / Metronidazole 250 mg;Clindamycin 300 mg
16 Evaluation of Omega-3 Polyunsaturated Fatty Acids Plus Low-dose Aspirin Daily Supplementation in Surgical Therapy to Treat Generalized Aggressive Periodontitis: Randomized Controlled Clinical Trial Active, not recruiting NCT03093207 Phase 2, Phase 3 Aspirin
17 Clinical Effects of Doxycycline in the Treatment of Aggressive Periodontitis: Comparative Clinical Study Completed NCT03727620 Phase 1, Phase 2 amoxicillin plus metronidazole;Doxycycline
18 Evaluation of Effectiveness of Chlorhexidine Intracanal Medicament on Periodontal Healing in Concomitant Endodontic and Periodontal Disease With Communication : A Randomized Controlled Clinical Trial Completed NCT02627326 Phase 2
19 The Affect of Orthodontic Treatment on the Periodontal Status of Patients With Aggressive Periodontitis Unknown status NCT01510808
20 Polymorphonuclear Cells' Sensitivity to Aggregatibacter Actinomycetemcomitans Bacteria in Patients With Aggressive Periodontitis Unknown status NCT02010307
21 Clinical and Radiographic Evaluation of Guided Tissue Regeneration With Radiation-sterilized Allogenic Bone Grafts or Xenogenic Grafts for the Treatment of Intrabony Defects in Aggressive Periodontitis: A Randomized Clinical Trial Unknown status NCT03340012
22 Evaluation of the Health of Peri-implant Tissues Around Immediately Placed Dental Implants in Aggressive Periodontitis Patients Versus Periodontally Healthy Individuals in Maxillary Esthetic Zone Unknown status NCT03218228
23 Comparison Between Surgical Access and Repeated Applications of APDT to Residual Pockets Treatment in Generalized Aggressive Periodontitis: Randomized Clinical Trial Unknown status NCT03140059
24 Chronic Presence of Epstein Barr Virus in Epithelial Cells From Gingiva is Associated With Periodontitis Unknown status NCT01246596
25 Effects of Smoking on Non-surgical Periodontal Therapy in Generalized Aggressive Periodontitis Completed NCT03512938
26 Gene Expression Profiles in Generalized Aggressive Periodontitis: A Gene Network-based Microarray Analysis Completed NCT02327533
27 Effect of Surgical Periodontal Therapy on the RANKL/OPG System : Do we Need Osteo-immune Modulation Targeting RANKL? Completed NCT02190773
28 Comparison of the Physiologic and Biochemical Alterations in the Healthy and Affected Sites of Chronic and Aggressive Periodontitis Patients Completed NCT03625414
29 Evaluation of the Local Effect of Nonsurgical Periodontal Treatment of Generalized Aggressive Periodontitis Associated or Not With Systemic Antibiotics and Photodynamic Therapy.: a Randomized Clinical Trial Completed NCT03142776 systemic clarithromycin
30 Clarithromycin as Adjuvant to Periodontal Debridement in the Treatment of Generalized Aggressive Periodontitis: Randomized Clinical Trial Completed NCT02829983 Clarithromycin;Placebo
31 Immunolocalization of 1,25,Dihydroxyvitamin D3 in Aggressive Periodontitis Patients Completed NCT02282800
32 Metagenomic and Immune-inflammatory Analysis of Individuals With Generalized Aggressive Periodontitis and Their Descendants. Completed NCT03933514
33 Clinical And Microbiological Evaluations Of Adjunctive Photodynamic Therapy To Non-Surgical Periodontal Treatment In Patients With Generalized Aggressive Periodontitis Completed NCT03412331
34 Clinical, Immunological and Microbiological Evaluation of Experimental Gingivitis and Peri-implant Mucositis in Patients With History of Agressive Periodontal Disease Completed NCT03713567
35 Enamel Matriz Derivate for Treatment of Proximal Class II Furcation Defects: a Randomized Clinical Trial Completed NCT03320135
36 Gingival Crevicular Fluid Levels Of Monocyte Chemoattractant Protein-1 in Patients With Aggressive Periodontitis Completed NCT02927704
37 Assessment of Pentraxin-3 Levels in Gingival Crevicular Fluid and Saliva in Periodontal Health and Disease Completed NCT03128502
38 Evaluation of Active Matrix Metalloproteinase-8 (aMMP-8) Chair-side Test in Different Periodontal Disease and Healthy Implants Completed NCT03527901
39 Comparison Of Er,Cr:YSGG and Diode Laser on the Periodontal Parameters and Cytokines Levels in Patients With Generalized Aggressive Periodontitis Completed NCT03034824
40 Influence of Smoking on Fibroblast Apoptosis in Patients With Chronic and Aggressive Periodontitis Completed NCT02111005
41 Effect of Non-surgical Periodontal Treatment on GCF HIF-1α, VEGF and TNF-α Levels in Generalized Aggressive Periodontitis Patients. Completed NCT04020315
42 The Evaluation of MCP-1 and CCR-2 Gene Polymorphisms Frequency and The Effects of This Polymorphism on Gene Expression in Patients With Aggressive Periodontitis Completed NCT02817568
43 Interaction Between Immune Cells and Bacteria Associated With Periodontitis Completed NCT03225950
44 Critical Role of Interleukin-34 in Gingival Crevicular Fluid as a Potential Markers of Inflammation in Patients With Periodontitis Completed NCT04223869
45 Smoking Dependence (Fagerström) as a Relevant Indicator for Tobacco Related Studies in Periodontology. Completed NCT03901066
46 Gingival Crevicular Fluid and Salivary HIF-1α, VEGF and TNF-α Levels in Different Periodontal Diseases Completed NCT03558906
47 Assessment of Nitro - Oxidative Stress in Periodontal Disease Completed NCT02127203
48 Efficacy of Sub-gingival Air-polishing With Erythritol in the Treatment of Periodontitis Completed NCT04264624
49 Effect of Scaling and Root Planing on Serum Renal Function Markers in Systematically Healthy Chronic Periodontitis Subjects - A Control Clinical Trial. Completed NCT02636114
50 Comparative Study Of Perforated Versus Non Perforated Collagen Membrane Combined With Nanohydroxyapatite In The Management Of Intrabony Defects Completed NCT03399279

Search NIH Clinical Center for Aggressive Periodontitis

Cochrane evidence based reviews: aggressive periodontitis

Genetic Tests for Aggressive Periodontitis

Anatomical Context for Aggressive Periodontitis

MalaCards organs/tissues related to Aggressive Periodontitis:

40
Bone, Neutrophil, Monocytes, Testes, Colon, B Cells, T Cells

Publications for Aggressive Periodontitis

Articles related to Aggressive Periodontitis:

(show top 50) (show all 1574)
# Title Authors PMID Year
1
Determination of the Role of Fusobacterium Nucleatum in the Pathogenesis in and Out the Mouth. 61
32573481 2020
2
Differences in the periodontal microbiome of successfully treated and persistent aggressive periodontitis. 61
32557763 2020
3
Moxifloxacin versus amoxicillin plus metronidazole as adjunctive therapy for generalized aggressive periodontitis: a pilot randomized controlled clinical trial. 61
32507863 2020
4
Aggregatibacter actinomycetemcomitans leukotoxin: From mechanism to targeted anti-toxin therapeutics. 61
32061022 2020
5
Aggressive periodontitis and NOD2 variants. 61
32424308 2020
6
Is sialic acid a promising marker for periodontal diseases? 61
32367865 2020
7
Differential expression of inflammasome regulatory transcripts in periodontal disease. 61
31557327 2020
8
Salivary Fingerprinting of Periodontal Disease by Infrared-ATR Spectroscopy. 61
31999389 2020
9
Salivary Microbiome Shifts in Response to Periodontal Treatment Outcome. 61
32223062 2020
10
A three-year study on periodontal microorganisms of short locking-taper implants and adjacent teeth in patients with history of periodontitis. 61
32070755 2020
11
The down-regulation of Notch 1 signaling contributes to the severity of bone loss in aggressive periodontitis. 61
31468527 2020
12
Global prevalence of aggressive periodontitis: A systematic review and meta-analysis. 61
32011029 2020
13
Effect of non-surgical periodontal treatment on gingival crevicular fluid hypoxia inducible factor-1 alpha, vascular endothelial growth factor and tumor necrosis factor-alpha levels in generalized aggressive periodontitis patients. 61
32246842 2020
14
Wnt5a is involved in LOX-1 and TLR4 induced host inflammatory response in peri-implantitis. 61
31593304 2020
15
Triclosan toothpaste as an adjunct therapy to plaque control in children from periodontitis families: a crossover clinical trial. 61
31907625 2020
16
Efficacy of regenerative therapy in aggressive periodontitis: a systematic review and meta-analysis of randomised controlled clinical trials. 61
32060656 2020
17
Correlation study on mtDNA polymorphisms as potential risk factors in aggressive periodontitis by NGS. 61
31715075 2020
18
Expression of mast cell in aggressive periodontitis. 61
32203646 2020
19
Salivary Del-1, IL-17, and LFA-1 levels in periodontal health and disease. 61
32153040 2020
20
Gingival recession after scaling and root planing with or without systemic metronidazole and amoxicillin: a re-review. 61
31938962 2020
21
Human leukocyte antigen-G polymorphisms in periodontitis. 61
31519120 2020
22
Association of oral health-related quality of life measures with aggressive and chronic periodontitis. 61
32232983 2020
23
Repeated application of photodynamic and antibiotic therapy as an adjunct to root surface debridement in patients with grade C and stage III or IV aggressive periodontitis. 61
31785387 2020
24
Treatment of intrabony defects with modified perforated membranes in aggressive periodontitis: a 4-year follow-up of a randomized controlled trial. 61
31324986 2020
25
Role of Aggregatibacter actinomycetemcomitans-induced autophagy in inflammatory response. 61
32170963 2020
26
Distinct Signaling Pathways Between Human Macrophages and Primary Gingival Epithelial Cells by Aggregatibacter actinomycetemcomitans. 61
32230992 2020
27
Tooth loss in aggressive periodontitis: Results 25 years after active periodontal therapy in a private practice. 61
31782533 2020
28
Novel rare frameshift variation in aggressive periodontitis: Exomic and familial-screening analysis. 61
31373687 2020
29
Herpesvirus-bacteria synergistic interaction in periodontitis. 61
31850623 2020
30
[Influential factors related to the long-term effect of periodontal-orthodontic treatment in patients with aggressive periodontitis and malocclusion]. 61
32074668 2020
31
The association of EGF rs2237051 variant, serum EGF levels and generalized aggressive periodontitis: a preliminary study. 61
32477838 2020
32
Association of P2RX7 functional variants with localized aggressive periodontitis. 61
31292966 2020
33
Turned surface implants in patients treated for periodontitis: Preliminary 10- to 20-year results of a long-term cohort study. 61
32424383 2020
34
Association of Vitamin D With Periodontal Disease: A Narrative Review. 61
32238981 2020
35
Impact of history of periodontitis on gene expression of bone-related factors in young patients. 61
32074214 2020
36
Correlations between Interleukin-33 and -1α Levels in Gingival Crevicular Fluid and Plasma in Patients with Chronic or Aggressive Periodontitis and Disease-free Subjects. 61
31761881 2019
37
The Association Between Some Macro and Trace Elements in Saliva and Periodontal Status. 61
31848920 2019
38
A novel multi-locus genetic risk score identifies patients with higher risk of generalized aggressive periodontitis. 61
31833563 2019
39
Local IL-10 level as a predictive factor in generalized aggressive periodontitis treatment response. 61
31448837 2019
40
Application of 2017 New Classification of Periodontal Diseases and Conditions to Localized Aggressive Periodontitis: Case Series. 61
31496127 2019
41
Long-Term Outcomes of Tooth-Implant-Supported Rehabilitation of Periodontally Compromised and Treated Patients Refusing Bone Grafting Surgical Therapies. 61
31219945 2019
42
Two different antibiotic protocols as adjuncts to one-stage full-mouth ultrasonic debridement to treat generalized aggressive periodontitis: A pilot randomized controlled clinical trial. 61
31257591 2019
43
Clinical and Microbiological Evaluation of Surgical and Nonsurgical Treatment of Aggressive Periodontitis. 61
31800752 2019
44
Anemia of inflammation associated with periodontitis: Analysis of two clinical studies. 61
31119743 2019
45
Evaluation of the effects of different forms of periodontal diseases on quality of life with OHIP-14 and SF-36 questionnaires: A cross-sectional study. 61
31125483 2019
46
Unique etiologic, demographic, and pathologic characteristics of localized aggressive periodontitis support classification as a distinct subcategory of periodontitis. 61
31668171 2019
47
Cholinergic signalling mechanisms and early implant healing phases in healthy versus generalized aggressive periodontitis patients: A prospective, case-control study. 61
31444906 2019
48
Cranberry Proanthocyanidins Neutralize the Effects of Aggregatibacter actinomycetemcomitans Leukotoxin. 61
31739483 2019
49
Mechanisms by Which Small RNAs Affect Bacterial Activity. 61
31547763 2019
50
Is the Use of Antimicrobial Photodynamic Therapy or Systemic Antibiotics More Effective in Improving Periodontal Health When Used in Conjunction with Localised Non-Surgical Periodontal Therapy? A Systematic Review. 61
31752098 2019

Variations for Aggressive Periodontitis

Expression for Aggressive Periodontitis

Search GEO for disease gene expression data for Aggressive Periodontitis.

Pathways for Aggressive Periodontitis

Pathways related to Aggressive Periodontitis according to GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.06 TNFSF11 TNFRSF11B TNF TLR4 TLR2 MMP8
2
Show member pathways
13.78 TNFSF11 TNFRSF11B TNF TLR4 IL6 IL4
3
Show member pathways
13.53 TNFSF11 TNF TLR4 TLR2 IL6 IL4
4
Show member pathways
13.45 TNFSF11 TNFRSF11B TNF IL6 IL4 IL1RN
5
Show member pathways
13.39 TNFSF11 TNF IL6 IL4 IL1B IL1A
6
Show member pathways
13.15 TNF TLR4 TLR2 IL6 IL1B IL10
7
Show member pathways
13 TNF TLR4 TLR2 IL6 IL1B CXCL8
8
Show member pathways
12.98 TNF IL6 IL4 IL1B IL1A IL10
9
Show member pathways
12.94 TNF TLR4 TLR2 IL6 IL1B IL1A
10
Show member pathways
12.85 TNF TLR4 TLR2 IL6 IL1RN IL1B
11
Show member pathways
12.81 TNF TLR4 TLR2 IL6 IL1B IL1A
12
Show member pathways
12.72 TNF TLR4 TLR2 IL6 IL4 IL1B
13
Show member pathways
12.71 TNFSF11 TNFRSF11B TNF TLR4 TLR2 IL1B
14
Show member pathways
12.71 TNF TLR4 TLR2 IL6 IL4 IL1B
15 12.69 TNFSF11 TNF TLR2 IL4 IL1RN IL1B
16
Show member pathways
12.48 TNF TLR2 IL6 IL4 IL1B CXCL8
17
Show member pathways
12.46 TNF TLR4 IL6 IL1B IL1A CXCL8
18 12.45 TNF TLR4 TLR2 IL6 IL1B CXCL8
19 12.43 TNF TLR4 IL1B CXCL8
20 12.41 TNF TLR4 IL6 IL1B FCGR2A CXCL8
21
Show member pathways
12.4 TNF TLR4 TLR2 IL6 IL1A CXCL8
22
Show member pathways
12.4 TNF IL6 IL4 IL1B IL1A IL10
23
Show member pathways
12.38 TNF IL6 IL10 CXCL8
24
Show member pathways
12.37 TNF IL6 IL4 IL1B
25 12.36 TNF TLR4 IL6 IL1B CXCL8
26
Show member pathways
12.36 TNF TLR4 TLR2 IL4 IL1B IL1A
27
Show member pathways
12.32 TNF TLR4 TLR2 IL6 IL4 IL1B
28 12.3 TNF IL6 IL1RN IL1B IL1A IL10
29
Show member pathways
12.27 TNF IL6 IL1B IL10
30
Show member pathways
12.27 TNF TLR4 IL1B IL1A
31 12.25 TNF TLR4 TLR2 IL6
32 12.19 TNFSF11 TNFRSF11B TNF IL1B IL1A FCGR2A
33 12.17 VDR TNF TLR4 TLR2 IL6 IL1B
34 12.15 TNF IL6 IL4 IL10 FCGR2A
35 12.15 TNF TLR4 IL6 IL1B IL10 CXCL8
36
Show member pathways
12.12 TLR4 TLR2 IL1B IL1A
37 12.11 TNF IL6 IL4 IL1B IL1A IL10
38 12.09 TNFSF11 TNF TLR4 IL1B CXCL8
39
Show member pathways
12.09 TNF TLR4 TLR2 IL6 IL1B IL10
40 12.07 TNF IL6 IL1B IL1A CXCL8
41 12.06 TNF IL6 IL4 IL1B IL1A
42 12.05 IL6 IL1B IL1A CXCL8
43 12.05 TNF TLR4 TLR2 IL6 IL1B IL10
44 12.05 TNF TLR4 IL6 IL4 IL1B IL1A
45
Show member pathways
12.01 TLR4 TLR2 IL6 IL4 IL1B
46 12 IL10 FPR1 FCGR2A DEFB1
47 11.91 TNF IL4 IL1B IL10
48 11.88 TNF IL6 IL1B IL10
49 11.86 TNF TLR4 IL6 IL1B IL1A IL10
50
Show member pathways
11.84 TNFSF11 TNFRSF11B TNF

GO Terms for Aggressive Periodontitis

Cellular components related to Aggressive Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 TNFSF11 TNFRSF11B TNF MMP8 IL6 IL4
2 extracellular space GO:0005615 9.44 TNFSF11 TNFRSF11B TNF MMP8 IL6 IL4

Biological processes related to Aggressive Periodontitis according to GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.33 VDR TNFRSF11B TLR4 TLR2 IL6 IL4
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.21 VDR TNFSF11 TNF TLR4 TLR2 IL6
3 neutrophil degranulation GO:0043312 10.13 TLR2 MMP8 FPR1 FCGR2A CTSC
4 negative regulation of cell proliferation GO:0008285 10.11 VDR TLR2 IL6 IL1B IL1A IL10
5 response to lipopolysaccharide GO:0032496 10.02 TLR4 TLR2 IL1B IL10
6 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 10.02 TNFSF11 TNF TLR4 IL1B IL1A
7 inflammatory response GO:0006954 10.02 TNF TLR4 TLR2 IL6 IL1RN IL1B
8 activation of MAPK activity GO:0000187 9.98 TNF TLR4 IL1B FPR1
9 defense response to Gram-positive bacterium GO:0050830 9.97 TNF TLR2 IL6 DEFB1
10 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.97 TNFSF11 TNF TLR4 TLR2 IL6 IL1B
11 positive regulation of DNA-binding transcription factor activity GO:0051091 9.96 TNFSF11 TNF IL6 IL1B IL10
12 positive regulation of gene expression GO:0010628 9.96 VDR TNFSF11 TNF TLR4 TLR2 MMP8
13 positive regulation of inflammatory response GO:0050729 9.94 TNF TLR4 TLR2 IL1B
14 positive regulation of JNK cascade GO:0046330 9.92 TNFSF11 TNF TLR4 MMP8 IL1B
15 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.91 TNF IL6 IL4
16 response to glucocorticoid GO:0051384 9.91 TNF IL6 IL1RN IL10
17 positive regulation of T cell proliferation GO:0042102 9.9 IL6 IL4 IL1B
18 positive regulation of interferon-gamma production GO:0032729 9.89 TNF TLR4 IL1B
19 positive regulation of nitric oxide biosynthetic process GO:0045429 9.88 TNF TLR4 MMP8 IL1B
20 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.87 TNF IL1B IL1A
21 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.87 IL4 IL1B IL1A
22 negative regulation of interleukin-6 production GO:0032715 9.87 TNF TLR4 IL10
23 positive regulation of cytokine secretion GO:0050715 9.85 TNF IL1A IL10
24 positive regulation of JAK-STAT cascade GO:0046427 9.85 TNF IL6 IL10
25 microglial cell activation GO:0001774 9.85 TNF TLR2 IL4
26 positive regulation of vascular endothelial growth factor production GO:0010575 9.85 IL6 IL1B IL1A
27 lipopolysaccharide-mediated signaling pathway GO:0031663 9.85 TNF TLR4 TLR2 IL1B
28 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.85 TNF TLR4 TLR2 MMP8 IL1B
29 negative regulation of neurogenesis GO:0050768 9.84 TNF IL6 IL1B
30 positive regulation of interleukin-8 production GO:0032757 9.84 TNF TLR4 TLR2 IL1B
31 positive regulation of interleukin-10 production GO:0032733 9.83 TLR4 TLR2 IL4
32 inflammatory response to antigenic stimulus GO:0002437 9.82 IL1RN IL1B IL1A
33 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.82 TNF TLR4 IL6
34 positive regulation of glial cell proliferation GO:0060252 9.81 TNF IL6 IL1B
35 positive regulation of interleukin-8 secretion GO:2000484 9.8 TNF TLR4 TLR2
36 positive regulation of interleukin-6 secretion GO:2000778 9.8 TNF TLR4 TLR2 IL1B IL1A
37 positive regulation of interleukin-6 production GO:0032755 9.8 TNF TLR4 TLR2 MMP8 IL6 IL1B
38 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.79 TNF IL1B IL10
39 positive regulation of chemokine biosynthetic process GO:0045080 9.78 TNF IL4 IL1B
40 positive regulation of chemokine production GO:0032722 9.78 TNF TLR4 TLR2 IL6
41 response to molecule of bacterial origin GO:0002237 9.77 TLR2 IL10 CXCL8
42 positive regulation of MHC class II biosynthetic process GO:0045348 9.76 TLR4 IL4 IL10
43 cellular response to lipopolysaccharide GO:0071222 9.76 VDR TNF TLR4 IL6 IL1B IL1A
44 regulation of neuroinflammatory response GO:0150077 9.74 MMP8 IL6
45 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.74 IL4 IL10
46 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.74 IL1RN IL10
47 cellular response to lipoteichoic acid GO:0071223 9.74 TLR4 TLR2
48 negative regulation of lipid storage GO:0010888 9.74 TNF IL6
49 regulation of establishment of endothelial barrier GO:1903140 9.73 TNF IL1B
50 endothelial cell apoptotic process GO:0072577 9.73 TNF IL10

Molecular functions related to Aggressive Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.32 TNFSF11 TNFRSF11B TNF IL6 IL4 IL1RN
2 lipopolysaccharide receptor activity GO:0001875 9.16 TLR4 TLR2
3 interleukin-1 receptor binding GO:0005149 9.13 IL1RN IL1B IL1A

Sources for Aggressive Periodontitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
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56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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