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AGING
MCID: AGN016
MIFTS: 44

Aging (AGING)

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Genes Tissues Related diseases Publications
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Aliases & Classifications for Aging

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MalaCards integrated aliases for Aging:

IMPROVED
Name: Aging 57 75

External Ids:

OMIM® 57 502000
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Summaries for Aging

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OMIM®: 57 Progressive damage to mitochondrial DNA (mtDNA) during life is thought to contribute to aging processes. This notion is supported by the observation of an aging-related accumulation in human mtDNA of oxidative and alkylation derivatives of nucleotides, of small deletions and insertions, and of large deletions, although their low frequency raises questions about their functional significance (Michikawa et al., 1999). (502000) (Updated 24-Oct-2022)

MalaCards based summary: Aging is related to premature aging and werner syndrome. An important gene associated with Aging is BCYRN1 (Brain Cytoplasmic RNA 1), and among its related pathways/superpathways are Gene expression (Transcription) and Disease. Affiliated tissues include brain, skeletal muscle and bone marrow, and related phenotypes are Decreased viability and Decreased viability

Wikipedia: 75 Senescence (/sɪˈnɛsəns/) or biological aging is the gradual deterioration of functional characteristics... more...
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Related Diseases for Aging

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Diseases related to Aging via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2221)
# Related Disease Score Top Affiliating Genes
1 premature aging 32.8 SOD2 LMNA
2 werner syndrome 32.7 WRN TP53 SIRT1 LMNA
3 hutchinson-gilford progeria syndrome 32.3 WRN TP53 SOD2 LMNA
4 short syndrome 31.6 TP53 IGF1R AKT1
5 alzheimer disease, familial, 1 31.4 SOD2 SIRT1 PPARG MTOR IGF1 BCYRN1
6 vascular disease 31.2 TP53 PPARG NAMPT IGF1R IGF1
7 cardiovascular system disease 31.1 SIRT1 PPARG NAMPT IGF1 AKT1
8 glucose intolerance 31.0 PPARG LMNA IGF1 FOXO1
9 insulin-like growth factor i 31.0 IGF1R IGF1 AKT1
10 leptin deficiency or dysfunction 31.0 PPARGC1A PPARG NAMPT IGF1 AKT1
11 prediabetes syndrome 31.0 PPARGC1A PPARG NAMPT IGF1
12 muscular atrophy 30.9 TP53 MTOR LMNA IGF1R
13 lipid metabolism disorder 30.9 SIRT1 PPARGC1A PPARG LMNA IGF1 AKT1
14 fatty liver disease 30.9 SIRT1 PPARGC1A PPARG IGF1
15 cataract 30.9 WRN TP53 SOD2 SIRT1 LMNA IGF1
16 huntington disease 30.8 TP53 SIRT1 PPARGC1A PPARG IGF1 FOXO3
17 interstitial lung disease 2 30.7 TP53 PPARG MTOR IGF1 AKT1
18 hyperinsulinism 30.7 TP53 PPARG IGF1R IGF1 FOXO1 AKT1
19 premature menopause 30.7 TP53 SIRT6 SIRT1 MTOR IGF1 FOXO3
20 rhabdomyosarcoma 2 30.7 TP53 IGF1R FOXO1 AKT1
21 heart disease 30.7 SOD2 PPARGC1A PPARG NAMPT MTOR LMNA
22 hyperglycemia 30.6 SOD2 PPARGC1A PPARG NAMPT IGF1R IGF1
23 skin atrophy 30.6 WRN LMNA IGF1
24 eye disease 30.6 TP53 SIRT1 PPARG MTOR IGF1R IGF1
25 acne 30.6 PPARG MTOR IGF1 FOXO1
26 non-alcoholic fatty liver disease 30.6 TP53 SOD2 SIRT6 SIRT3 SIRT1 PPARGC1A
27 spinal cord disease 30.5 TP53 MTOR AKT1
28 myocardial infarction 30.5 WRN TP53 SOD2 SIRT1 PPARGC1A PPARG
29 gastrointestinal stromal tumor 30.5 TP53 MTOR IGF1R AKT1
30 colonic benign neoplasm 30.4 TP53 PPARG IGF1 AKT1
31 non-alcoholic steatohepatitis 30.4 SIRT1 PPARGC1A PPARG AKT1
32 hypertension, essential 30.4 TP53 SOD2 SIRT3 SIRT1 PPARGC1A PPARG
33 amyotrophic lateral sclerosis 1 30.3 TP53 SOD2 SIRT6 SIRT3 SIRT1 PPARGC1A
34 myeloma, multiple 30.3 TP53 MTOR IGF1R IGF1 AKT1
35 breast adenocarcinoma 30.2 TP53 IGF1R IGF1 AKT1
36 leukemia, acute myeloid 30.2 TP53 SIRT1 MTOR IGF1R FOXO3 FOXO1
37 overnutrition 30.1 SIRT1 PPARGC1A PPARG NAMPT IGF1 AKT1
38 body mass index quantitative trait locus 11 30.1 TP53 SOD2 SIRT6 SIRT3 SIRT1 PPARGC1A
39 rett syndrome 30.1 REST MTOR IGF1R IGF1 AKT1
40 gestational diabetes 30.1 PPARGC1A PPARG NAMPT IGF1
41 osteogenic sarcoma 30.1 TP53 IGF1R IGF1 AKT1
42 type 2 diabetes mellitus 30.1 WRN TP53 SOD2 SIRT6 SIRT3 SIRT1
43 osteoporosis 30.0 WRN TP53 SOD2 SIRT6 SIRT3 SIRT1
44 tuberous sclerosis 30.0 TP53 MTOR IGF1 AKT1
45 peripheral nervous system disease 30.0 TP53 SIRT1 PPARGC1A PPARG MTOR LMNA
46 hypertrophic cardiomyopathy 29.9 PPARGC1A PPARG LMNA IGF1 AKT1
47 dilated cardiomyopathy 29.8 TP53 SOD2 SIRT3 SIRT1 PPARGC1A PPARG
48 glucose metabolism disease 29.8 PPARGC1A PPARG IGF1 AKT1
49 endometrial cancer 29.8 TP53 PPARG MTOR IGF1R IGF1 FOXO3
50 diabetes mellitus 29.7 WRN TP53 SOD2 SIRT6 SIRT3 SIRT1

Graphical network of the top 20 diseases related to Aging:



Diseases related to Aging
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Symptoms & Phenotypes for Aging

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Clinical features from OMIM®:

502000 (Updated 24-Oct-2022)

GenomeRNAi Phenotypes related to Aging according to GeneCards Suite gene sharing:

25 (show all 37)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 10.35 MTOR
2 Decreased viability GR00055-A-2 10.35 MTOR
3 Decreased viability GR00221-A-1 10.35 AKT1 FOXO1 IGF1R MTOR PPARG
4 Decreased viability GR00221-A-2 10.35 AKT1 FOXO1 IGF1R PPARG
5 Decreased viability GR00221-A-3 10.35 AKT1 FOXO1 IGF1R PPARG
6 Decreased viability GR00221-A-4 10.35 AKT1 MTOR PPARG
7 Decreased viability GR00249-S 10.35 AKT1
8 Decreased viability GR00301-A 10.35 IGF1R
9 Decreased viability GR00342-S-1 10.35 MTOR
10 Decreased viability GR00342-S-2 10.35 IGF1R MTOR
11 Decreased viability GR00386-A-1 10.35 PPARG
12 Decreased viability GR00402-S-2 10.35 IGF1R
13 Increased shRNA abundance (Z-score > 2) GR00366-A-10 10.02 SIRT3
14 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.02 FOXO3
15 Increased shRNA abundance (Z-score > 2) GR00366-A-122 10.02 FOXO3
16 Increased shRNA abundance (Z-score > 2) GR00366-A-129 10.02 NAMPT
17 Increased shRNA abundance (Z-score > 2) GR00366-A-139 10.02 PPARG
18 Increased shRNA abundance (Z-score > 2) GR00366-A-145 10.02 FOXO3 PPARG
19 Increased shRNA abundance (Z-score > 2) GR00366-A-153 10.02 IGF1R
20 Increased shRNA abundance (Z-score > 2) GR00366-A-163 10.02 FOXO3
21 Increased shRNA abundance (Z-score > 2) GR00366-A-17 10.02 PPARG
22 Increased shRNA abundance (Z-score > 2) GR00366-A-203 10.02 PPARG
23 Increased shRNA abundance (Z-score > 2) GR00366-A-204 10.02 FOXO3
24 Increased shRNA abundance (Z-score > 2) GR00366-A-205 10.02 NAMPT
25 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.02 FOXO3 NAMPT
26 Increased shRNA abundance (Z-score > 2) GR00366-A-32 10.02 NAMPT
27 Increased shRNA abundance (Z-score > 2) GR00366-A-36 10.02 PPARG
28 Increased shRNA abundance (Z-score > 2) GR00366-A-52 10.02 SIRT3
29 Increased shRNA abundance (Z-score > 2) GR00366-A-57 10.02 FOXO3
30 Increased shRNA abundance (Z-score > 2) GR00366-A-58 10.02 SIRT3
31 Increased shRNA abundance (Z-score > 2) GR00366-A-60 10.02 IGF1R
32 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.02 IGF1R
33 Increased shRNA abundance (Z-score > 2) GR00366-A-91 10.02 SIRT3
34 Decreased viability with paclitaxel GR00179-A-1 9.55 IGF1 MTOR
35 Decreased viability with paclitaxel GR00179-A-2 9.55 IGF1 MTOR
36 Decreased viability with paclitaxel GR00179-A-3 9.55 MTOR
37 Reduced mammosphere formation GR00396-S 9.17 FOXO1 IGF1 IGF1R LMNA MTOR PPARG

MGI Mouse Phenotypes related to Aging:

45 (show all 26)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.5 AKT1 FOXO1 FOXO3 IGF1 IGF1R LMNA
2 growth/size/body region MP:0005378 10.48 AKT1 FOXO1 FOXO3 IGF1 IGF1R LMNA
3 nervous system MP:0003631 10.46 AKT1 FOXO3 IGF1 IGF1R LMNA MTOR
4 adipose tissue MP:0005375 10.45 AKT1 FOXO1 IGF1 IGF1R LMNA MTOR
5 cellular MP:0005384 10.45 AKT1 FOXO1 FOXO3 IGF1 IGF1R LMNA
6 cardiovascular system MP:0005385 10.41 AKT1 FOXO1 FOXO3 IGF1 IGF1R LMNA
7 liver/biliary system MP:0005370 10.37 AKT1 FOXO1 IGF1R LMNA PPARG PPARGC1A
8 neoplasm MP:0002006 10.36 AKT1 FOXO1 FOXO3 IGF1 IGF1R PPARG
9 endocrine/exocrine gland MP:0005379 10.35 AKT1 FOXO1 FOXO3 IGF1 IGF1R LMNA
10 muscle MP:0005369 10.34 AKT1 FOXO1 IGF1 IGF1R LMNA MTOR
11 immune system MP:0005387 10.34 AKT1 FOXO1 FOXO3 IGF1 IGF1R LMNA
12 behavior/neurological MP:0005386 10.33 AKT1 FOXO1 FOXO3 IGF1R LMNA MTOR
13 normal MP:0002873 10.27 AKT1 FOXO1 IGF1 LMNA MTOR PPARG
14 renal/urinary system MP:0005367 10.26 FOXO3 IGF1 LMNA MTOR PPARG PPARGC1A
15 reproductive system MP:0005389 10.21 AKT1 FOXO1 FOXO3 IGF1 IGF1R LMNA
16 skeleton MP:0005390 10.2 AKT1 FOXO1 FOXO3 IGF1 IGF1R LMNA
17 limbs/digits/tail MP:0005371 10.19 FOXO1 IGF1 IGF1R LMNA RGN SIRT1
18 digestive/alimentary MP:0005381 10.18 FOXO1 FOXO3 IGF1R LMNA PPARGC1A SIRT1
19 hearing/vestibular/ear MP:0005377 10.16 IGF1 IGF1R LMNA PPARG REST RGN
20 pigmentation MP:0001186 10.1 LMNA NAMPT PPARGC1A REST SOD2 TP53
21 respiratory system MP:0005388 10.1 AKT1 FOXO3 IGF1 IGF1R LMNA MTOR
22 hematopoietic system MP:0005397 10.06 AKT1 FOXO1 FOXO3 IGF1 IGF1R LMNA
23 craniofacial MP:0005382 10.05 FOXO1 IGF1R LMNA SIRT1 SIRT6 TP53
24 vision/eye MP:0005391 10.03 FOXO3 LMNA NAMPT PPARG PPARGC1A REST
25 mortality/aging MP:0010768 9.91 AKT1 FOXO1 FOXO3 IGF1 IGF1R LMNA
26 integument MP:0010771 9.47 AKT1 FOXO1 FOXO3 IGF1 IGF1R LMNA
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Drugs & Therapeutics for Aging

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Genetic Tests for Aging

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Anatomical Context for Aging

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Organs/tissues related to Aging:

MalaCards : Brain, Skeletal Muscle, Bone Marrow, Skin, Prefrontal Cortex, Heart, Cortex
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Publications for Aging

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Articles related to Aging:

(show top 50) (show all 30011)
# Title Authors PMID Year
1
Short telomeres are sufficient to cause the degenerative defects associated with aging. 62 57
19944403 2009
2
Lamin A-dependent nuclear defects in human aging. 62 57
16645051 2006
3
Genome dynamics in aging mice. 62 57
12421760 2002
4
Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication. 62 57
11274426 2001
5
Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication. 62 57
10531063 1999
6
Accumulation of deletions in human mitochondrial DNA during normal aging: analysis by quantitative PCR. 62 57
1463763 1992
7
Mitochondrial genetics: a paradigm for aging and degenerative diseases? 62 57
1533953 1992
8
Increased cell-to-cell variation in gene expression in ageing mouse heart. 57
16791200 2006
9
Gene regulation and DNA damage in the ageing human brain. 57
15190254 2004
10
Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes. 57
12538859 2003
11
Mitochondrial DNA polymorphisms associated with longevity in a Finnish population. 57
12483296 2003
12
Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine. 57
10900004 2000
13
Role of nuclear background and in vivo environment in variable segregation behavior of the aging-dependent T414G mutation at critical control site for human fibroblast mtDNA replication. 57
15328912 1999
14
Mitochondrial genotype associated with longevity. 57
9449878 1998
15
Growing old: the most common mitochondrial disease of all? 57
1303273 1992
16
Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain. 57
1303287 1992
17
Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age. 57
1303288 1992
18
Evidence for and against the causal involvement of mitochondrial DNA mutation in mammalian ageing. 57
1383763 1992
19
Molecular hallmarks of long non-coding RNAs in aging and its significant effect on aging-associated diseases. 62
36254975 2023
20
Mesenchymal stem cells derived from patients with premature aging syndromes display hallmarks of physiological aging. 62
36104080 2022
21
Brain age vector: A measure of brain aging with enhanced neurodegenerative disorder specificity. 62
36094058 2022
22
Aging astrocytes metabolically support aging axon function by proficiently regulating astrocyte-neuron lactate shuttle. 62
35863500 2022
23
Epigenetic aging: Biological age prediction and informing a mechanistic theory of aging. 62
35726002 2022
24
Cognitive reserve and brain maintenance in aging and dementia: An integrative review. 62
33492168 2022
25
Aging, care and dependency in multimorbidity: how do relationships affect older Bangladeshi women's use of homecare and health services? 62
34255615 2022
26
Urinary phthalate metabolites and their mixtures are associated with advanced sperm epigenetic aging in a general population. 62
35988832 2022
27
Early adversities accelerate epigenetic aging into adulthood: a 10-year, within-subject analysis. 62
35137412 2022
28
Proanthocyanidins inhibit the apoptosis and aging of nucleus pulposus cells through the PI3K/Akt pathway delaying intervertebral disc degeneration. 62
35491814 2022
29
Similarity and difference between aging and puncture-induced intervertebral disc degeneration. 62
35072275 2022
30
Tissue-Specific Gamma-Flicker Light Noninvasively Ameliorates Retinal Aging. 62
34698960 2022
31
Cellular and Mitochondrial Quality Control Mechanisms in Maintaining Homeostasis in Aging. 62
35850516 2022
32
The role of nicotinamide mononucleotide (NMN) in anti-aging, longevity, and its potential for treating chronic conditions. 62
35441939 2022
33
Barriers to Aging in Place for Rural, Institutionalized Older Adults: A Qualitative Exploration. 62
32981469 2022
34
Aging and skeletal muscle force control: Current perspectives and future directions. 62
35815914 2022
35
Aging and cancer epigenetics: Where do the paths fork? 62
36103298 2022
36
Alterations in high-dimensional T-cell profile and gene signature of immune aging in HIV-infected older adults without viremia. 62
36036630 2022
37
Reduced endosomal microautophagy activity in aging associates with enhanced exocyst-mediated protein secretion. 62
36116133 2022
38
Identification of aging-associated immunotypes and immune stability as indicators of post-vaccination immune activation. 62
36081314 2022
39
Sexual Minority Stress and Cellular Aging in Methamphetamine-Using Sexual Minority Men With Treated HIV. 62
35980781 2022
40
Production of MHCII-expressing classical monocytes increases during aging in mice and humans. 62
36040389 2022
41
Selenium: An Antioxidant with a Critical Role in Anti-Aging. 62
36235150 2022
42
Microbial and immune factors regulate brain maintenance and aging. 62
35914431 2022
43
The Rapid Naming Test: Development and initial validation in typically aging adults. 62
33771087 2022
44
Health of Vietnamese Older Adults and Caregiver's Psychological Status in the United States: Result from the Vietnamese Aging and Care Survey. 62
32543347 2022
45
Age and Physical Activity Levels in Companion Dogs: Results From the Dog Aging Project. 62
35486978 2022
46
The morphology of the femoral footprint of the anterior cruciate ligament changes with aging from a large semicircular shape to a small flat ribbon-like shape. 62
35318508 2022
47
Neural Control of Human Locomotor Adaptation: Lessons about Changes with Aging. 62
34014124 2022
48
A Systematic Review and Correlational Meta-Analysis of Factors Associated With Resilience of Normally Aging, Community-Living Older Adults. 62
34346489 2022
49
Melatonin-related signaling pathways and their regulatory effects in aging organisms. 62
35895186 2022
50
FoxO3 Regulates the Progress and Development of Aging and Aging-Related Diseases. 62
36239722 2022
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Variations for Aging

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Expression for Aging

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Search GEO for disease gene expression data for Aging.
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Pathways for Aging

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Pathways related to Aging according to GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Super pathways Score Top Affiliating Genes
1
Gene expression (Transcription) 66
Show member pathways
 14.09 WRN TP53 SOD2 SIRT3 SIRT1 REST
2
Disease 66
Show member pathways
 13.82 WRN TP53 SOD2 REST MTOR LMNA
3
Signal Transduction 66
13.81 TP53 SIRT6 REST PPARG MTOR IGF1R
4
PIP3 activates AKT signaling 66
Show member pathways
 13.12 TP53 REST PPARG MTOR FOXO3 FOXO1
5
PI3K-Akt signaling pathway 74
Show member pathways
 13 TP53 PPARGC1A MTOR IGF1R IGF1 FOXO3
6
NFAT and Cardiac Hypertrophy 64
Show member pathways
 12.88 MTOR IGF1R IGF1 FOXO3 AKT1
7
IL-9 Signaling Pathways 65
Show member pathways
 12.87 NAMPT MTOR FOXO3 FOXO1 AKT1
8
Signaling by Receptor Tyrosine Kinases 66
12.84 REST MTOR IGF1R IGF1 AKT1
9
Malignant pleural mesothelioma 74
12.77 AKT1 FOXO1 IGF1 IGF1R MTOR PPARGC1A
10
Endometrial cancer 74
Show member pathways
 12.76 AKT1 FOXO3 IGF1 IGF1R MTOR TP53
11
4-1BB Pathway 64
Show member pathways
 12.71 TP53 SIRT6 SIRT3 SIRT1 AKT1
12
Overview of interferons-mediated signaling pathway 74
Show member pathways
 12.65 TP53 MTOR IGF1R IGF1 AKT1
13
Angiopoietin-like protein 8 regulatory pathway 74
Show member pathways
 12.57 MTOR IGF1R FOXO3 FOXO1 AKT1
14
Breast cancer pathway 74
Show member pathways
 12.52 AKT1 IGF1 IGF1R MTOR TP53
15
Glucose / Energy Metabolism 3
12.49 AKT1 IGF1R NAMPT PPARG PPARGC1A SIRT1
16
NF-kappaB Pathway 70
Show member pathways
 12.45 AKT1 IGF1R MTOR TP53
17
Apoptosis and survival FAS signaling cascades 22
Show member pathways
 12.37 LMNA IGF1R IGF1 AKT1
18
Development Ligand-independent activation of ESR1 and ESR2 22
Show member pathways
 12.35 PPARG IGF1R IGF1 AKT1
19
Development IGF-1 receptor signaling 22
Show member pathways
 12.33 AKT1 FOXO3 IGF1 IGF1R MTOR TP53
20
p53 Signaling 64
Show member pathways
 12.27 AKT1 SIRT1 SIRT3 SIRT6 TP53
21
MAPK Signaling: Mitogens 65
Show member pathways
 12.25 TP53 MTOR LMNA IGF1R FOXO3 FOXO1
22
Integrated breast cancer pathway 74
12.2 TP53 SIRT1 MTOR FOXO1 AKT1
23
T-cell activation SARS-CoV-2 74
Show member pathways
 12.19 AKT1 FOXO3 MTOR TP53
24
MicroRNAs in cardiomyocyte hypertrophy 74
Show member pathways
 12.18 MTOR IGF1R IGF1 AKT1
25
Transcription Androgen Receptor nuclear signaling 22
Show member pathways
 12.18 MTOR IGF1R IGF1 FOXO3 AKT1
26
AMP-activated protein kinase signaling 74
Show member pathways
 12.17 TP53 SIRT1 PPARGC1A MTOR AKT1
27
mTOR Signaling 65
12.15 TP53 MTOR IGF1R AKT1
28
GDNF signaling 74
12.12 MTOR FOXO3 FOXO1 AKT1
29
Adipogenesis 74
12.09 FOXO1 IGF1 LMNA NAMPT PPARG PPARGC1A
30
FOXO-mediated transcription 66
Show member pathways
 12.08 SOD2 SIRT3 SIRT1 PPARGC1A FOXO3 FOXO1
31
Thermogenesis 74
Show member pathways
 12.05 SIRT6 PPARGC1A PPARG MTOR
32
Gastrin signaling pathway 74
12.04 PPARG FOXO3 FOXO1 AKT1
33
Interleukin-4 and Interleukin-13 signaling 66
12.02 TP53 FOXO3 FOXO1 AKT1
34
Senescence and autophagy in cancer 74
12 TP53 MTOR IGF1R IGF1
35
NAD metabolism 22
Show member pathways
 11.99 SIRT6 SIRT3 SIRT1 NAMPT
36
TGF-beta Signaling Pathways 65
11.99 PPARG MTOR FOXO3 FOXO1 AKT1
37
DNA damage response (only ATM dependent) 74
11.93 TP53 SOD2 FOXO3
38
Notch Signaling Pathways 65
11.92 SIRT1 MTOR AKT1
39
Mesenchymal Stem Cells and Lineage-specific Markers 65
11.9 PPARGC1A PPARG IGF1
40
PI3K / Akt Signaling 3
11.88 AKT1 FOXO1 FOXO3
41
mTOR Pathway 70
Show member pathways
 11.86 TP53 PPARG MTOR IGF1R AKT1
42
TP53 Regulates Metabolic Genes 66
11.85 TP53 MTOR AKT1
43
MAPK Signaling: Oxidative Stress 65
11.85 TP53 SIRT1 FOXO3 FOXO1
44
Constitutive Signaling by AKT1 E17K in Cancer 66
Show member pathways
 11.85 MTOR FOXO3 FOXO1 AKT1
45
Thyroid hormones production and peripheral downstream signaling effects 74
11.83 TP53 SIRT6 PPARGC1A PPARG MTOR FOXO1
46
MECP2 and associated Rett syndrome 74
11.82 REST MTOR IGF1R IGF1 AKT1
47
Clock-controlled autophagy in bone metabolism 74
11.81 MTOR IGF1 AKT1
48
Head and neck squamous cell carcinoma 74
11.81 TP53 MTOR IGF1R AKT1
49
Regulation of TP53 Expression and Degradation 66
Show member pathways
 11.78 TP53 MTOR AKT1
50
Defective Intrinsic Pathway for Apoptosis 66
Show member pathways
 11.78 TP53 SOD2 LMNA FOXO3
Sources

GO Terms for Aging

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Cellular components related to Aging according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 alphav-beta3 integrin-IGF-1-IGF1R complex GO:0035867 9.26 IGF1R IGF1
2 PML body GO:0016605 9.23 TP53 SIRT1 PPARGC1A MTOR

Biological processes related to Aging according to GeneCards Suite gene sharing:

(show all 39)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of DNA-templated transcription GO:0045893 10.51 TP53 REST PPARGC1A PPARG IGF1 FOXO3
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.46 AKT1 FOXO1 FOXO3 IGF1 NAMPT PPARG
3 positive regulation of gene expression GO:0010628 10.43 TP53 PPARGC1A PPARG MTOR LMNA IGF1
4 negative regulation of cell population proliferation GO:0008285 10.4 LMNA PPARG REST SIRT6 SOD2 TP53
5 cellular response to DNA damage stimulus GO:0006974 10.38 FOXO1 MTOR SIRT1 SIRT6 TP53 WRN
6 positive regulation of apoptotic process GO:0043065 10.31 FOXO1 FOXO3 PPARG REST SIRT1 TP53
7 negative regulation of gene expression GO:0010629 10.29 TP53 SIRT1 REST PPARG IGF1 AKT1
8 cellular response to oxidative stress GO:0034599 10.23 FOXO1 FOXO3 PPARGC1A SOD2
9 aging GO:0007568 10.21 WRN SOD2 RGN IGF1R FOXO3
10 cellular response to starvation GO:0009267 10.19 WRN SIRT1 MTOR FOXO1
11 cellular response to insulin stimulus GO:0032869 10.18 PPARG IGF1R FOXO1 AKT1
12 circadian regulation of gene expression GO:0032922 10.18 SIRT6 SIRT1 PPARGC1A NAMPT
13 response to heat GO:0009408 10.16 MTOR IGF1 AKT1
14 positive regulation of miRNA transcription GO:1902895 10.15 TP53 PPARG FOXO3
15 phosphatidylinositol 3-kinase signaling GO:0014065 10.15 AKT1 IGF1 IGF1R
16 cellular response to amyloid-beta GO:1904646 10.14 IGF1R IGF1 FOXO3
17 energy homeostasis GO:0097009 10.14 SIRT1 PPARGC1A FOXO1
18 regulation of circadian rhythm GO:0042752 10.14 SIRT6 PPARGC1A PPARG MTOR
19 cellular glucose homeostasis GO:0001678 10.1 SIRT1 PPARGC1A FOXO1
20 neuronal stem cell population maintenance GO:0097150 10.09 REST FOXO3 FOXO1
21 insulin-like growth factor receptor signaling pathway GO:0048009 10.09 AKT1 IGF1 IGF1R
22 negative regulation of apoptotic process GO:0043066 10.09 AKT1 FOXO1 IGF1 IGF1R MTOR RGN
23 negative regulation of release of cytochrome c from mitochondria GO:0090201 10.08 AKT1 IGF1 LMNA
24 insulin receptor signaling pathway GO:0008286 10.07 AKT1 FOXO1 IGF1R NAMPT
25 response to starvation GO:0042594 10.05 PPARGC1A PPARG FOXO3
26 positive regulation of gluconeogenesis GO:0045722 10.03 SIRT1 PPARGC1A FOXO1
27 cellular senescence GO:0090398 10.03 WRN TP53 LMNA IGF1R
28 cellular response to hypoxia GO:0071456 10.03 FOXO3 LMNA MTOR PPARG SIRT1 TP53
29 response to oxidative stress GO:0006979 9.97 WRN TP53 SOD2 SIRT1 AKT1
30 positive regulation of superoxide dismutase activity GO:1901671 9.95 SIRT3 RGN
31 protein deacetylation GO:0006476 9.95 SIRT6 SIRT3 SIRT1
32 negative regulation of helicase activity GO:0051097 9.93 TP53 SIRT1
33 response to nutrient levels GO:0031667 9.89 SOD2 MTOR IGF1R FOXO3
34 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176 9.88 AKT1 SIRT1 SOD2
35 positive regulation of fatty acid oxidation GO:0046321 9.85 PPARGC1A PPARG
36 cellular response to hyperoxia GO:0071455 9.83 PPARG FOXO1
37 negative regulation of cardiac muscle hypertrophy in response to stress GO:1903243 9.8 PPARG LMNA FOXO1
38 glucose homeostasis GO:0042593 9.65 SIRT6 PPARG IGF1R FOXO3 FOXO1 AKT1
39 rhythmic process GO:0048511 9.23 TP53 SIRT1 PPARGC1A PPARG NAMPT MTOR

Molecular functions related to Aging according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 10.22 WRN TP53 SIRT6 REST PPARG FOXO1
2 sequence-specific DNA binding GO:0043565 10.2 SIRT3 REST PPARGC1A PPARG FOXO3 FOXO1
3 chromatin DNA binding GO:0031490 10.01 FOXO1 FOXO3 PPARGC1A SIRT6
4 NAD+ ADP-ribosyltransferase activity GO:0003950 9.73 SIRT6 SIRT3 SIRT1
5 NAD+ binding GO:0070403 9.73 SIRT6 SIRT3 SIRT1
6 NAD-dependent histone H3K9 deacetylase activity GO:0046969 9.67 SIRT6 SIRT1
7 NAD+-protein ADP-ribosyltransferase activity GO:1990404 9.62 SIRT6 SIRT3 SIRT1
8 protein lysine deacetylase activity GO:0033558 9.46 SIRT6 SIRT3 SIRT1
9 NAD-dependent protein deacetylase activity GO:0034979 9.43 SIRT6 SIRT3 SIRT1
10 NAD-dependent histone deacetylase activity GO:0017136 9.1 SIRT6 SIRT3 SIRT1
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2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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