Aging disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

AGING MCID: AGN016 MIFTS: 56	Aging (AGING)
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

Sources

Aliases & Classifications for Aging

MalaCards integrated aliases for Aging:

Name: Aging ⁵⁶ ⁷⁴

External Ids:

OMIM ⁵⁶ 502000

Sources

Summaries for Aging

OMIM : ⁵⁶ Progressive damage to mitochondrial DNA (mtDNA) during life is thought to contribute to aging processes. This notion is supported by the observation of an aging-related accumulation in human mtDNA of oxidative and alkylation derivatives of nucleotides, of small deletions and insertions, and of large deletions, although their low frequency raises questions about their functional significance (Michikawa et al., 1999). (502000)

MalaCards based summary : Aging is related to premature aging and hutchinson-gilford progeria syndrome. An important gene associated with Aging is BCYRN1 (Brain Cytoplasmic RNA 1), and among its related pathways/superpathways are Endometrial cancer and MAPK signaling pathway. The drugs Midazolam and Dexmedetomidine have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and heart, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : ⁷⁴ Senescence (/sɪˈnɛsəns/) or biological aging is the gradual deterioration of functional characteristics.... more...

Sources

Related Diseases for Aging

Diseases related to Aging via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 5809)

#	Related Disease	Score	Top Affiliating Genes
1	premature aging	34.0	TP63 PDGFRB LMNA
2	hutchinson-gilford progeria syndrome	32.7	WRN TP53 SIRT3 LMNA
3	atypical werner syndrome	32.6	WRN LMNA
4	huntington disease	31.9	TP53 SOD1 SNCA PPARG AKT1
5	skin carcinoma	31.8	TP53 MAPK1 JUN AKT1
6	osteonecrosis	31.8	SERPINE1 PPARG HIF1A
7	medulloblastoma	31.8	WRN TP53 PDGFRB MAPK1 JUN HIF1A
8	kidney cancer	31.8	TP53 SERPINE1 MAPK1 HIF1A AKT1
9	varicocele	31.8	TP53 SOD1 HIF1A
10	pulmonary fibrosis, idiopathic	31.8	TP53 SERPINE1 MMP7 HIF1A AKT1
11	vascular disease	31.7	TP53 SOD1 SERPINE1 PPARG NAMPT MAPK1
12	osteoporosis	31.7	WRN TP53 SERPINE1 PPARG MAPK1 LMNA
13	acute promyelocytic leukemia	31.6	TP53 SERPINE1 PPARG MAPK1 JUN HIF1A
14	ewing sarcoma	31.6	TP53 PDGFRB MAPK1 HIF1A AKT1
15	kaposi sarcoma	31.6	TP53 MAPK1 JUN HIF1A AKT1
16	leukemia, acute myeloid	31.6	TP53 PDGFRB MAPK1 JUN HIF1A AKT1
17	fibrosarcoma	31.6	TP53 SERPINE1 MAPK1 JUN HIF1A
18	non-alcoholic fatty liver disease	31.6	SIRT3 SERPINE1 PPARG NAMPT JUN AKT1
19	endometrial cancer	31.4	TP53 PPARG MMP7 MAPK1 JUN HIF1A
20	neuroblastoma	31.3	TP53 SOD1 SNCA PPARG PDGFRB MAPK1
21	primary lateral sclerosis, adult, 1	31.3	SOD1 SNCA
22	microvascular complications of diabetes 5	31.3	SOD1 SERPINE1 HIF1A AKT1
23	hypertension, essential	31.1	TP53 SOD1 SIRT3 SERPINE1 PPARG NAMPT
24	alzheimer disease	31.1	TP53 SOD1 SNCA PPARG MAPK1 JUN
25	arteriosclerosis	31.0	SERPINE1 PPARG KL HIF1A
26	retinitis pigmentosa	30.8	TP53 SOD1 SNCA PPARG PDGFRB LMNA
27	peripheral nervous system disease	30.7	TP53 SOD1 SNCA LMNA AKT1
28	sleep apnea	30.7	SERPINE1 PPARG HIF1A
29	wilms tumor 1	30.6	TP63 TP53 KCNQ1DN AKT1
30	pancreatic cancer	30.6	TP53 PPARG PDGFRB MMP7 MAPK1 JUN
31	skin atrophy	30.5	WRN LMNA KL
32	hyperglycemia	30.5	SOD1 SERPINE1 PPARG NAMPT JUN HIF1A
33	overnutrition	30.5	SERPINE1 PPARG NAMPT AKT1
34	diabetes mellitus, noninsulin-dependent	30.5	WRN TP53 SOD1 SNCA SIRT3 SERPINE1
35	myocardial infarction	30.5	WRN TP53 SERPINE1 PPARG MMP7 HIF1A
36	gastric adenocarcinoma	30.4	TP53 PDGFRB MAPK1 JUN HIF1A AKT1
37	tuberous sclerosis	30.4	TP53 PDGFRB MAPK1 AKT1
38	sarcoma	30.4	TP53 PDGFRB MAPK1 JUN HIF1A AKT1
39	cardiovascular system disease	30.3	SOD1 SERPINE1 PPARG NAMPT AKT1
40	body mass index quantitative trait locus 11	30.2	TP53 SIRT3 SERPINE1 PPARG NAMPT LMNA
41	glioblastoma multiforme	30.2	TP53 PPARG PDGFRB MAPK1 JUN HIF1A
42	breast adenocarcinoma	30.2	TP53 SERPINE1 MAPK1 AKT1
43	renal cell carcinoma, nonpapillary	30.2	TP53 SNCA PDGFRB MMP7 JUN HIF1A
44	cholangiocarcinoma	30.2	TP53 MMP7 MAPK1 AKT1
45	cervical cancer	30.1	TP63 TP53 MMP7 MAPK1 JUN HIF1A
46	pneumoconiosis	30.1	SOD1 SERPINE1 JUN
47	diabetes mellitus	30.0	WRN TP53 SOD1 SIRT3 SERPINE1 PPARG
48	breast fibroadenoma	30.0	TP63 TP53 HIF1A
49	bladder urothelial carcinoma	30.0	TP53 SERPINE1 MMP7 HIF1A AKT1
50	estrogen-receptor positive breast cancer	29.9	TP53 HIF1A AKT1

Graphical network of the top 20 diseases related to Aging:

Sources

Symptoms & Phenotypes for Aging

Clinical features from OMIM:

502000

GenomeRNAi Phenotypes related to Aging according to GeneCards Suite gene sharing:

²⁶ (show all 11)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00055-A-1	10.09	MAPK1
2	Decreased viability	GR00055-A-2	10.09	MAPK1
3	Decreased viability	GR00221-A-1	10.09	AKT1 MAPK1 PDGFRB PPARG
4	Decreased viability	GR00221-A-2	10.09	AKT1 PPARG SOD1 JUN
5	Decreased viability	GR00221-A-3	10.09	AKT1 MAPK1 PDGFRB PPARG SOD1 JUN
6	Decreased viability	GR00221-A-4	10.09	AKT1 MAPK1 PDGFRB PPARG SOD1
7	Decreased viability	GR00249-S	10.09	AKT1 MAPK1 SOD1 JUN
8	Decreased viability	GR00342-S-1	10.09	MAPK1 PDGFRB
9	Decreased viability	GR00342-S-2	10.09	MAPK1
10	Decreased viability	GR00342-S-3	10.09	MAPK1
11	Decreased viability	GR00386-A-1	10.09	PPARG JUN

MGI Mouse Phenotypes related to Aging:

⁴⁵ (show all 26)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	10.57	AKT1 HIF1A JUN KL LMNA MAPK1
2	cellular	MP:0005384	10.54	AKT1 HIF1A JUN KL LMNA MAPK1
3	growth/size/body region	MP:0005378	10.53	AKT1 HIF1A JUN KL LMNA MAPK1
4	homeostasis/metabolism	MP:0005376	10.5	AKT1 HIF1A JUN KL LMNA MAPK1
5	behavior/neurological	MP:0005386	10.47	AKT1 HIF1A JUN KL LMNA MAPK1
6	immune system	MP:0005387	10.47	AKT1 HIF1A JUN KL LMNA MAPK1
7	endocrine/exocrine gland	MP:0005379	10.43	AKT1 HIF1A JUN KL LMNA MAPK1
8	integument	MP:0010771	10.43	AKT1 HIF1A JUN KL LMNA MAPK1
9	mortality/aging	MP:0010768	10.43	AKT1 HIF1A JUN KL LMNA MAPK1
10	hematopoietic system	MP:0005397	10.4	AKT1 HIF1A JUN KL LMNA MAPK1
11	adipose tissue	MP:0005375	10.33	AKT1 KL LMNA PDGFRB PPARG RGN
12	digestive/alimentary	MP:0005381	10.3	HIF1A KL LMNA MAPK1 MMP7 PDGFRB
13	liver/biliary system	MP:0005370	10.27	AKT1 HIF1A JUN KL LMNA MAPK1
14	embryo	MP:0005380	10.24	AKT1 HIF1A JUN MAPK1 NAMPT PDGFRB
15	nervous system	MP:0003631	10.22	AKT1 HIF1A JUN KL LMNA MAPK1
16	craniofacial	MP:0005382	10.21	HIF1A KL LMNA MAPK1 PDGFRB TP53
17	muscle	MP:0005369	10.16	AKT1 HIF1A KL LMNA MAPK1 PDGFRB
18	neoplasm	MP:0002006	10.13	AKT1 HIF1A MAPK1 MMP7 PPARG SERPINE1
19	hearing/vestibular/ear	MP:0005377	10.11	KL LMNA MAPK1 PPARG RGN SOD1
20	limbs/digits/tail	MP:0005371	10.11	HIF1A KL LMNA PDGFRB RGN TP53
21	normal	MP:0002873	10.07	AKT1 HIF1A JUN LMNA PDGFRB PPARG
22	reproductive system	MP:0005389	10	AKT1 KL LMNA MAPK1 PDGFRB PPARG
23	renal/urinary system	MP:0005367	9.97	HIF1A KL LMNA PDGFRB PPARG SERPINE1
24	respiratory system	MP:0005388	9.85	AKT1 HIF1A JUN KL LMNA MAPK1
25	skeleton	MP:0005390	9.83	AKT1 HIF1A JUN KL LMNA MAPK1
26	vision/eye	MP:0005391	9.47	HIF1A JUN KL LMNA MAPK1 MMP7

Sources

Drugs & Therapeutics for Aging

Drugs for Aging (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 891)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Midazolam

Approved, Illicit

Phase 4

59467-70-8

4192

Dexmedetomidine

Approved, Vet_approved

Phase 4

113775-47-6

5311068 68602

Oxycodone

Approved, Illicit, Investigational

Phase 4

76-42-6

5284603

Remifentanil

Approved

Phase 4

132875-61-7

60815

Sufentanil

Approved, Investigational

Phase 4

56030-54-7

41693

Esmolol

Approved

Phase 4

103598-03-4, 81147-92-4

59768

Cisatracurium

Approved

Phase 4

96946-41-7

Pantoprazole

Approved

Phase 4

102625-70-7

4679

Rilpivirine

Approved

Phase 4

500287-72-9

Ticlopidine

Approved

Phase 4

55142-85-3

5472

Ramipril

Approved

Phase 4

87333-19-5

5362129

Estradiol

Approved, Investigational, Vet_approved

Phase 4

50-28-2

5757

Polyestradiol phosphate

Approved

Phase 4

28014-46-2

Perindopril

Approved

Phase 4

107133-36-8, 82834-16-0

107807

Acetylcysteine

Approved, Investigational

Phase 4

616-91-1

12035

Phylloquinone

Approved, Investigational

Phase 4

84-80-0

Angiotensin II

Approved, Investigational

Phase 4

4474-91-3, 11128-99-7, 68521-88-0

172198

Valsartan

Approved, Investigational

Phase 4

137862-53-4

60846

Enalapril

Approved, Vet_approved

Phase 4

75847-73-3

40466924 5362032

Lisinopril

Approved, Investigational

Phase 4

76547-98-3, 83915-83-7

5362119

Enalaprilat

Approved

Phase 4

76420-72-9

6917719

Ropivacaine

Approved

Phase 4

84057-95-4

71273 175805

Rivaroxaban

Approved

Phase 4

366789-02-8

Darunavir

Approved

Phase 4

206361-99-1, 635728-49-3

213039

Hydrochlorothiazide

Approved, Vet_approved

Phase 4

58-93-5

3639

Menthol

Approved

Phase 4

2216-51-5

16666

Tacrolimus

Approved, Investigational

Phase 4

104987-11-3

445643 439492 6473866

Hydralazine

Approved

Phase 4

86-54-4

3637

Sevoflurane

Approved, Vet_approved

Phase 4

28523-86-6

5206

Heparin

Approved, Investigational

Phase 4

9005-49-6

46507594 772

Clopidogrel

Approved

Phase 4

113665-84-2, 120202-66-6

60606

Nitroglycerin

Approved, Investigational

Phase 4

55-63-0

4510

Ciprofloxacin

Approved, Investigational

Phase 4

85721-33-1

2764

Candesartan cilexetil

Approved

Phase 4

145040-37-5

2540

Aminosalicylic Acid

Approved

Phase 4

65-49-6

4649

Simvastatin

Approved

Phase 4

79902-63-9

54454

Cimetidine

Approved, Investigational

Phase 4

51481-61-9

2756

Doxazosin

Approved

Phase 4

74191-85-8

3157

Telmisartan

Approved, Investigational

Phase 4

144701-48-4

65999

Olmesartan

Approved, Investigational

Phase 4

144689-24-7, 144689-63-4

158781 130881

Nebivolol

Approved, Investigational

Phase 4

99200-09-6, 118457-14-0, 152520-56-4

71301

Atenolol

Approved

Phase 4

29122-68-7

2249

Indapamide

Approved

Phase 4

26807-65-8

3702

Spirapril

Approved

Phase 4

83647-97-6

5311447

Quinapril

Approved, Investigational

Phase 4

85441-61-8

54892

Eszopiclone

Approved, Investigational

Phase 4

138729-47-2

969472

Desflurane

Approved

Phase 4

57041-67-5

42113

Mirabegron

Approved

Phase 4

223673-61-8

9865528

Dalteparin

Approved

Phase 4

9005-49-6

Amlodipine

Approved

Phase 4

88150-42-9

2162

Interventional clinical trials:

(show top 50) (show all 3936)

#	Name	Status	NCT ID	Phase	Drugs
1	Medication Induced Blood Pressure Reduction; Assessment of Cerebral Perfusion and Cognition in Hypertensive Elderly	Unknown status	NCT00966199	Phase 4	anti-hypertensive medication
2	Different Doses Rosuvastatin Effect on Telomere-telomerase System in Acute Coronary Syndrome Patients After Percutaneous Coronary INtervention: RETAIN Study	Unknown status	NCT02299245	Phase 4	rosuvastatin
3	A Prospective Evaluation of Capecitabine and Metabolite Pharmacokinetics in Elderly Breast and Colorectal Cancer Patients and Their Association With Toxicity and Molecular Markers of Enzyme Activity and Aging	Unknown status	NCT03465202	Phase 4	Capecitabine
4	Outcome Comparison Between PFNA and InterTAN in Intertrochanteric Fractures	Unknown status	NCT01797237	Phase 4
5	The Effect of Dexmedetomidine on Postoperative Recovery in Elderly Patients With Femoral Neck Fracture Undergoing Hip Hemi-arthroplasty	Unknown status	NCT01934049	Phase 4	Total Intravenous Anesthesia and Peripheral nerve blocks
6	Cognitive, Behavioral and Aging Effects of Pain Medication in Alcohol Users	Unknown status	NCT02945293	Phase 4
7	Can Methylphenidate (Ritalin) Improve Memory and Attention in Mild Cognitive Impairment? A Combined Behaviour-EEG Study	Unknown status	NCT02326038	Phase 4	Methylphenidate
8	Phase 4 Study of Long Term Postoperative Cognitive Dysfunction After Laparoscopic Cholecystectomy in the Elderly Patients	Unknown status	NCT02301676	Phase 4	Sevoflurane;propofol
9	An Open-Label Pilot Study to Compare the Efficacy of Escalating Doses of IncobotulinumtoxinA (Xeomin®) in the Treatment of Glabellar Rhytids	Unknown status	NCT01583478	Phase 4
10	A Randomised, Placebo Controlled, Double Blind, Cross-over, Single Center Clinical Study to Investigate the Effect of Heart Rate Reduction With Ivabradine on Vascular Elastic Properties and Endothelial Function in Patients With Stable Coronary Heart Disease	Unknown status	NCT01768585	Phase 4	Ivabradine;Placebo
11	Group Mindfulness-Based Cognitive Therapy for the Treatment of Late-Life Depression and Anxiety Symptoms in Primary Care: A Randomized Controlled Trial	Unknown status	NCT02777905	Phase 4
12	Treatment of Intertrochanteric Fracture With New Type of Intramedullary Nail	Unknown status	NCT01437176	Phase 4
13	Frailty and Cognitive Function Assessment of TAVI Patients (The Hungarian Frailty Score) - Observational, Prospective, Singe Center Study	Unknown status	NCT02650388	Phase 4
14	The Efficacy and Optimal Dose of Sufentanil in Patient Controlled Analgesia After Moderate Surgery	Unknown status	NCT02503826	Phase 4	Sufentanil;Sufentanil;Sufentanil;Midazolam;propofol;cisatracurium
15	Multi-Centre, Prospective, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Vardenafil in Men With Erectile Dysfunction Caused by Spinal Cord Injury	Unknown status	NCT00725790	Phase 4	Vardenafil;Placebo
16	Does Early Re-administration of Aspirin/Clopidogrel Increase the Risk of Bleeding From Artificial Ulcer After EMR or ESD?	Unknown status	NCT01621451	Phase 4	aspirin and/or clopidogrel;aspirin and/or clopidogrel
17	CHADSS: Chagas Disease Scan Study	Unknown status	NCT01650792	Phase 4	Aspirin
18	The Effect of a Higher Dose of Dehydroepiandrosterone (DHEA) Supplementation on the Number of Oocytes Obtained During IVF in Poor Ovarian Responders	Unknown status	NCT02357472	Phase 4	dehydroepiandrosterone
19	Effects of a Chronical Treatment With Benfotiamine in People With Type 2 Diabetes Mellitus on Pre- and Postprandial Endothelial Function, as Well as on the Function of the Autonomic Nervous System	Unknown status	NCT00446810	Phase 4	Benfotiamine;Placebo
20	A PROSPECTIVE, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF THE SUPPLEMENTATION WITH KIOLIC® IN PATIENTS WITH DIAGNOSIS OF METABOLIC SYNDROME TO IMPROVE ENDOTHELIAL FUNCTION AND INFLAMMATORY STATE. "KYMES"	Unknown status	NCT01168700	Phase 4	aged garlic extract;Placebo
21	A Phase IV 48 Week, Open Label, Pilot Study of Darunavir Boosted by Cobicistat in Combination With Rilpivirine to Treat HIV+ Naïve Subjects (PREZENT)	Unknown status	NCT02404233	Phase 4	darunavir/cobicistat;rilpivirine
22	Effect of Controlled Hypotension on Cerebral Oxygen Saturation in Patients Undergoing Functional Endoscopic Sinus Surgery: a Prospective Randomized Single Blind Clinical Trial	Unknown status	NCT02967029	Phase 4	Esmolol Hydrochloride;Remifentanil Hydrochloride
23	The Effect on an Ionic Silver Dressing in Head and Neck Patients With Malignant Fungating Wound	Unknown status	NCT00813631	Phase 4
24	Ejaculatory Sparing vs. Non-ejaculatory Sparing GreenLightTM Laser Photoselective Vaporization of the Prostate (PVP): A Randomized Double Blind Sexual and Urodynamic Assessment	Unknown status	NCT02749604	Phase 4
25	Endovascular Treatment Versus Optimal Medical Treatment of Atherosclerotic Renal Artery for Preserving Renal Function of the Ischemic Kidney.	Unknown status	NCT01208714	Phase 4	Optimal medical therapy
26	Randomized Study Comparing Switching to Raltegravir-based Antiretroviral Versus Maintaining Any Other Antiretroviral Therapy in HIV Monoinfected Patients Impact on Fatty Liver and Liver Fibrosis Assessed by Noninvasive Diagnostic Methods	Unknown status	NCT02210715	Phase 4	Isentress.
27	Discovery of Effects of Retinol on Human Skin Aging in Individuals of East Asian Descent	Completed	NCT02906566	Phase 4	Retinol;Placebo
28	Metformin in Longevity Study (MILES).	Completed	NCT02432287	Phase 4	Metformin;Placebo
29	Physiologic Effects of PRMS & Testosterone in the Debilitated Elderly	Completed	NCT00018356	Phase 4	testosterone
30	Genomic Outcomes of Metformin	Completed	NCT02986659	Phase 4	Metformin;Placebo
31	Multi-parameter Immune Profile Associated With the Humoral Response to Influenza Vaccine, Vaxigrip® in Healthy and Frail Elderly Subjects Aged 65-90 Years in Singapore	Completed	NCT03266237	Phase 4	Vaxigrip®
32	hCG Priming Prior to COH in Poor Responder IVF Patients	Completed	NCT00870025	Phase 4
33	Aging White Matter Changes, Executive Dysfunction and Depression	Completed	NCT00918684	Phase 4	Escitalopram
34	The Effects of Pectin on Aging-related Changes in Intestinal Barrier Function, Immune Function and Microbial Composition	Completed	NCT02376270	Phase 4
35	Single Cell Molecular Analysis of Influenza Vaccine Induced T Cell Responses in Adults 65 Years of Age or Older	Completed	NCT04077424	Phase 4
36	Canadian Study of the Use of Injectable POLY-L-LACTIC Acid (Sculptra Therapy) in Aesthetic Medicine	Completed	NCT00447551	Phase 4	Poly-L-Lactic Acid
37	Patient Satisfaction With Treatment of BOTOX® Cosmetic for the Temporary Correction of Moderate to Severe Glabellar Lines	Completed	NCT00856414	Phase 4
38	A Comparative Randomized Double-Blinded Study of the Effect of Dysport and Botox on Forehead Wrinkles and EMG Activity	Completed	NCT00434863	Phase 4	botulinum toxin type A
39	Volume Restoration of the Aging Midface With Sculptra Aesthetic	Completed	NCT01307865	Phase 4	injectable poly-L-lactic acid
40	A Phase IV, Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Single-Center Study on the Effects of a Proprietary Blend of Herbal Extract Supplement on Cellular Detoxification, Inflammation, and Cumulative Cognitive Index as Well as Gene Expression in Middle-Aged Adult Women.	Completed	NCT01598272	Phase 4
41	Clinical Evaluation of Day and Night Skin Care Creams Supplemented With MediCell Technology (MCT)'s Composition of Defensins and Supportive Molecules	Completed	NCT02765763	Phase 4	2-Minute Reveal Masque;24/7 Barrier Repair Cream;8-in-1 BioSerum;Null Formula 2-Minute Reveal Masque;Null Formula 24/7 Barrier Repair Cream;Null Formula 8-in-1 BioSerum
42	Immunogenicity of Pneumococcal Vaccination and Revaccination in Older Adults	Completed	NCT00239694	Phase 4
43	Split-face Study of Changing in Skin Physiology and Clinical Appearance After Microdroplet Placement of Stabilized Hyaluronic Acid in Aging Faces	Completed	NCT02312154	Phase 4
44	Randomized, Controlled, Multi-Centered, Double-Blind Investigation of Injectable Poly-L-Lactic Acid (Sculptra Aesthetic) for Improving Facial Wrinkles and Skin Quality	Completed	NCT02003833	Phase 4
45	Oral Administration of L-Arginine in Patients With Erectile Dysfunction	Completed	NCT00777075	Phase 4	L-arginine;Placebo
46	Mechanisms of Immune Reconstitution & Reduced Immune Activation Following Darunavir-based ART	Completed	NCT01869634	Phase 4	darunavir with ritonavir and fixed-dose viread+emtricitabine daily
47	3% Dihydroxyacetone (DHA or Sunless Tanning Agent) Inhibits Vitamin D Production in the Skin in Response to Ultraviolet Light	Completed	NCT00818467	Phase 4
48	A 1-year Randomised, Double-blind Placebo-controlled Study to Evaluate the Effects of Memantine on Rate of Brain Atrophy in Patients With Alzheimer's Disease	Completed	NCT00862940	Phase 4	Memantine;Placebo
49	Comparison of Clinical Outcome Parameters, the Patient Benefit Index (PBI) and Patient Satisfaction After Ablative Fractional Laser Treatment of Peri-orbital Rhytides	Completed	NCT00994474	Phase 4
50	A Prospective, Open Label, Randomized, Comparative, Split-Face Study Evaluating Reconstituted JUVÉDERM® Ultra Injectable Gel Versus COSMODERM® 1 Human Based Collagen Implant for the Treatment of Vertical Lip Rhytids and Radial Cheek Lines	Completed	NCT01212809	Phase 4

Search NIH Clinical Center for Aging

Sources

Genetic Tests for Aging

Sources

Anatomical Context for Aging

MalaCards organs/tissues related to Aging:

⁴⁰

Brain, Skin, Heart, Bone, Skeletal Muscle, Kidney, Testes

Sources

Publications for Aging

Articles related to Aging:

(show top 50) (show all 30015)

#	Title	Authors	PMID	Year
1	Lamin A-dependent nuclear defects in human aging. ⁵⁶ ⁶¹	Scaffidi P...Misteli T	16645051	2006
2	Genome dynamics in aging mice. ⁵⁶ ⁶¹	Dolle ME...Vijg J	12421760	2002
3	Mitochondrial genetics: a paradigm for aging and degenerative diseases? ⁵⁶ ⁶¹	Wallace DC	1533953	1992
4	Short telomeres are sufficient to cause the degenerative defects associated with aging. ⁵⁶	Armanios M...Greider CW	19944403	2009
5	Increased cell-to-cell variation in gene expression in ageing mouse heart. ⁵⁶	Bahar R...Vijg J	16791200	2006
6	Gene regulation and DNA damage in the ageing human brain. ⁵⁶	Lu T...Yankner BA	15190254	2004
7	Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes. ⁵⁶	Zhang J...Attardi G	12538859	2003
8	Mitochondrial DNA polymorphisms associated with longevity in a Finnish population. ⁵⁶	Niemi AK...Majamaa K	12483296	2003
9	Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication. ⁵⁶	Wang Y...Attardi G	11274426	2001
10	Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine. ⁵⁶	Dolle ME...Vijg J	10900004	2000
11	Role of nuclear background and in vivo environment in variable segregation behavior of the aging-dependent T414G mutation at critical control site for human fibroblast mtDNA replication. ⁵⁶	Michikawa Y...Attardi G	15328912	1999
12	Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication. ⁵⁶	Michikawa Y...Attardi G	10531063	1999
13	Mitochondrial genotype associated with longevity. ⁵⁶	Tanaka M...Yagi K	9449878	1998
14	Growing old: the most common mitochondrial disease of all? ⁵⁶	Harding AE	1303273	1992
15	Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain. ⁵⁶	Soong NW...Arnheim N	1303287	1992
16	Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age. ⁵⁶	Corral-Debrinski M...Wallace DC	1303288	1992
17	Accumulation of deletions in human mitochondrial DNA during normal aging: analysis by quantitative PCR. ⁵⁶	Simonetti S...Schon EA	1463763	1992
18	Evidence for and against the causal involvement of mitochondrial DNA mutation in mammalian ageing. ⁵⁶	Bittles AH	1383763	1992
19	Strength and aging resistance of monolithic zirconia: an update to current knowledge. ⁶¹	Kontonasaki E...Rigos AE	31768195	2020
20	Aging of starting solutions for nanoparticles synthesis with two different ultrasonication. ⁶¹	Enomoto N...Hojo J	32361276	2020
21	Involvement of protein S-nitrosylation in regulating beef apoptosis during postmortem aging. ⁶¹	Hou Q...Zhang W	32413758	2020
22	Silica infiltration in partially stabilized zirconia: Effect of hydrothermal aging on mechanical properties. ⁶¹	Campos TMB...Melo RM	32347214	2020
23	Effect of hydrothermal aging on the properties of zirconia with different levels of translucency. ⁶¹	Amarante JEV...Santos CD	32543411	2020
24	Analysis of free aniline in chrome-free leather accelerated aging. ⁶¹	Yujie M...Zhihua S	32408227	2020
25	The influence of probiotics on bile acids in diseases and aging. ⁶¹	Sivamaruthi BS...Chaiyasut C	32504921	2020
26	Potential health effects of dietary nitrate supplementation in aging and chronic degenerative disease. ⁶¹	Carter SJ...Coggan AR	32294579	2020
27	Response of tungsten (W) solubility and chemical fractionation to changes in soil pH and soil aging. ⁶¹	Oburger E...Wenzel WW	32413664	2020
28	Dataset of quantitative proteomic analysis to understand aging processes in rabbit liver. ⁶¹	Amin B...Robinson RAS	32490075	2020
29	Effects of polymer aging on sorption of 2,2',4,4'-tetrabromodiphenyl ether by polystyrene microplastics. ⁶¹	Wu J...Chai C	32289606	2020
30	The long-term environmental risks from the aging of organochlorine pesticide lindane. ⁶¹	Xu T...Sheng GD	32416373	2020
31	MRI-based biomarkers of accelerated aging and dementia risk in midlife: how close are we? ⁶¹	Elliott ML	32325150	2020
32	Nrf2 knockout dysregulates iron metabolism and increases the hemolysis through ROS in aging mice. ⁶¹	Liu Z...Chang YZ	32450168	2020
33	The emerging role of T follicular helper (TFH) cells in aging: Influence on the immune frailty. ⁶¹	Varricchi G...Rengo G	32344191	2020
34	Sleep, Noninvasive Brain Stimulation, and the Aging Brain: Challenges and Opportunities. ⁶¹	Romanella SM...Santarnecchi E	32380212	2020
35	Cognitive processes in aging effects on attentional alerting. ⁶¹	Erel H...Levy DA	32380362	2020
36	Traditional fermented foods with anti-aging effect: A concentric review. ⁶¹	Das G...Patra JK	32517898	2020
37	Antioxidant and anti-aging activities of polysaccharides from Cordyceps cicadae. ⁶¹	Zhu Y...Ouyang Z	32339570	2020
38	The effects of environmental stressors on candidate aging associated genes. ⁶¹	Andrawus M...Atzmon G	32344118	2020
39	Aging indicators for stored carioca beans. ⁶¹	Bento JAC...Moreira AS	32517899	2020
40	Wnt signaling pathway in aging-related tissue fibrosis and therapies. ⁶¹	Hu HH...Zhao YY	32272170	2020
41	Fracture force of CAD/CAM resin composite crowns after in vitro aging. ⁶¹	Rosentritt M...Preis V	31712983	2020
42	Multiple MuSK signaling pathways and the aging neuromuscular junction. ⁶¹	Fish LA...Fallon JR	32353380	2020
43	Role of microRNAs in neurodegeneration induced by environmental neurotoxicants and aging. ⁶¹	Singh T...Yadav S	32283224	2020
44	Aging Affects Fine and Coarse Coding of Orientation Information in Macaque Primary Visual Cortex. ⁶¹	Zhang B...Zhou Y	32407975	2020
45	Aging Equines: Understanding the Experience of Caring for a Geriatric Horse with a Chronic Condition. ⁶¹	Ballou ME...Dowling-Guyer S	32534771	2020
46	Senescent Cells: Emerging Targets for Human Aging and Age-Related Diseases. ⁶¹	Song S...Sun Y	32531228	2020
47	Circadian glucocorticoid oscillations preserve a population of adult hippocampal neural stem cells in the aging brain. ⁶¹	Schouten M...Fitzsimons CP	31222184	2020
48	Aortic remodeling is modest and sex-independent in mice when hypertension is superimposed on aging. ⁶¹	Spronck B...Humphrey JD	32068640	2020
49	Anti-aging properties of Dendrobium nobile Lindl.: From molecular mechanisms to potential treatments. ⁶¹	Nie X...Lu Y	32268205	2020
50	Next Steps Toward AMH as a Robust Biomarker for Assessing Ovarian Aging in Individual Women. ⁶¹	Fauser BCJM...Nelson SM	32315387	2020

Sources

Genes for Aging

Genes related to Aging (0 elite genes):

(show all 30)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	BCYRN1	Brain Cytoplasmic RNA 1	RNA Gene	150	Experimental evidence: Expression ³⁸	17553964
2	KCNQ1DN	KCNQ1 Downstream Neighbor	RNA Gene	150	Experimental evidence: Epigenetics ³⁸	22067257
3	PDGFRB	Platelet Derived Growth Factor Receptor Beta	Protein Coding	44.97	GeneCards inferred via : Disorders Publications Pathways & Interactions Functions Variants (show sections)
4	LMNA	Lamin A/C	Protein Coding	41.88	GeneCards inferred via : Disorders Publications Pathways & Interactions Functions Expressions (show sections)
5	WRN	WRN RecQ Like Helicase	Protein Coding	33.16	GeneCards inferred via : Publications Summaries Pathways & Interactions Functions (show sections)
6	SIRT3	Sirtuin 3	Protein Coding	32.42	GeneCards inferred via : Publications Summaries Pathways & Interactions Functions (show sections)
7	NAMPT	Nicotinamide Phosphoribosyltransferase	Protein Coding	32.26	GeneCards inferred via : Publications Summaries Pathways & Interactions Functions (show sections)
8	TP63	Tumor Protein P63	Protein Coding	31.42	GeneCards inferred via : Publications Summaries Pathways & Interactions Functions (show sections)
9	RGN	Regucalcin	Protein Coding	31.31	GeneCards inferred via : Publications Summaries Pathways & Interactions Functions (show sections)
10	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	25.13	GeneCards inferred via : Publications Pathways & Interactions Functions (show sections)
11	SNCA	Synuclein Alpha	Protein Coding	24.88	GeneCards inferred via : Publications Pathways & Interactions Functions (show sections)
12	SERPINE1	Serpin Family E Member 1	Protein Coding	24.85	GeneCards inferred via : Publications Pathways & Interactions Functions (show sections)
13	TP53	Tumor Protein P53	Protein Coding	24.65	GeneCards inferred via : Publications Pathways & Interactions Functions (show sections)
14	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	24.43	GeneCards inferred via : Publications Pathways & Interactions Functions (show sections)
15	KL	Klotho	Protein Coding	24.31	GeneCards inferred via : Publications Pathways & Interactions Functions (show sections)
16	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	24.28	GeneCards inferred via : Publications Pathways & Interactions Functions (show sections)
17	PPARG	Peroxisome Proliferator Activated Receptor Gamma	Protein Coding	24.19	GeneCards inferred via : Publications Pathways & Interactions Functions (show sections)
18	MMP7	Matrix Metallopeptidase 7	Protein Coding	24.14	GeneCards inferred via : Publications Pathways & Interactions Functions (show sections)
19	HIF1A	Hypoxia Inducible Factor 1 Subunit Alpha	Protein Coding	24.11	GeneCards inferred via : Publications Pathways & Interactions Functions (show sections)
20	SOD1	Superoxide Dismutase 1	Protein Coding	24.09	GeneCards inferred via : Publications Pathways & Interactions Functions (show sections)
21	TGFBR2	Transforming Growth Factor Beta Receptor 2	Protein Coding	24.08	GeneCards inferred via : Publications Pathways & Interactions Functions (show sections)
22	PARP1	Poly(ADP-Ribose) Polymerase 1	Protein Coding	24.05	GeneCards inferred via : Publications Pathways & Interactions Functions (show sections)
23	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	24.03	GeneCards inferred via : Publications Pathways & Interactions Functions (show sections)
24	PTEN	Phosphatase And Tensin Homolog	Protein Coding	23.92	GeneCards inferred via : Publications Pathways & Interactions Functions (show sections)
25	SIRT1	Sirtuin 1	Protein Coding	23.9	GeneCards inferred via : Publications Pathways & Interactions Functions (show sections)
26	SOD2	Superoxide Dismutase 2	Protein Coding	23.9	GeneCards inferred via : Publications Summaries Functions (show sections)
27	REST	RE1 Silencing Transcription Factor	Protein Coding	23.89	GeneCards inferred via : Publications Functions localization (show sections)
28	FOXO3	Forkhead Box O3	Protein Coding	23.88	GeneCards inferred via : Publications Pathways & Interactions Functions (show sections)
29	AGT	Angiotensinogen	Protein Coding	23.85	GeneCards inferred via : Publications Pathways & Interactions Functions (show sections)
30	EDN1	Endothelin 1	Protein Coding	23.85	GeneCards inferred via : Publications Pathways & Interactions Functions (show sections)

Sources

Variations for Aging

Sources

Expression for Aging

Search GEO for disease gene expression data for Aging.

Sources

Pathways for Aging

Pathways related to Aging according to GeneCards Suite gene sharing:

(show top 50) (show all 75)

#	Super pathways	Score	Top Affiliating Genes
1	Endometrial cancer ³⁶ Show member pathways Acute myeloid leukemia ³⁶ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁵ Chronic myeloid leukemia ³⁶ Colorectal cancer ³⁶ Pancreatic cancer ³⁶ Prostate cancer ³⁶ Signal transduction PTEN pathway ²² Thyroid cancer ³⁶	12.89	TP53 PPARG PDGFRB MAPK1 JUN AKT1
2	MAPK signaling pathway ³⁶ ¹	12.79	TP53 PDGFRB MAPK1 JUN AKT1
3	Downstream signaling events of B Cell Receptor (BCR) ⁶⁵ Show member pathways Activation of RAS in B cells ⁶⁵ Signaling by the B Cell Receptor (BCR) ⁶⁵	12.76	TP53 PDGFRB MAPK1 KL AKT1
4	Glioma ³⁶ Show member pathways Endocrine resistance ³⁶ Melanoma ³⁶ Non-small cell lung cancer ³⁶ Signaling Pathways in Glioblastoma ¹	12.71	TP53 PDGFRB MAPK1 JUN AKT1
5	Apoptosis Modulation and Signaling ¹ Show member pathways Apoptosis ³⁶ Apoptosis ¹ Apoptosis and survival Apoptotic TNF-family pathways ²² Apoptosis Signaling Pathways ⁶⁴	12.7	TP63 TP53 MAPK1 LMNA JUN AKT1
6	Pathways in cancer ³⁶	12.7	TP53 PPARG PDGFRB MAPK1 JUN HIF1A
7	4-1BB Pathway ⁶³ Show member pathways CD27 Pathway ⁶³ CD40 Signaling ⁶³ CMV and MAPK Pathways ⁶³ NF-KappaB Activation by EBV ⁶³ NF-kappaB Activation by Viruses ⁶³ PKR Pathway ⁶³ SUMO Pathway ⁶³ TNFR2 Pathway ⁶³	12.63	TP53 SIRT3 PDGFRB MAPK1 JUN AKT1
8	ErbB signaling pathway ³⁶ ¹ Show member pathways EGFR Inhibitor Pathway, Pharmacodynamics ⁶⁰ EGFR tyrosine kinase inhibitor resistance ³⁶ Renal cell carcinoma ³⁶ TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer ¹	12.58	TP53 PDGFRB MAPK1 JUN HIF1A AKT1
9	Apoptosis Pathway ⁷⁰ Show member pathways Akt Pathway ⁷⁰ NF-kappaB Pathway ⁷⁰	12.47	TP53 PDGFRB JUN AKT1
10	WNT Signaling ⁶³	12.45	TP53 MMP7 MAPK1 JUN AKT1
11	Shigellosis ³⁶	12.42	TP53 MAPK1 JUN AKT1
12	Phospholipase D signaling pathway ³⁶ Show member pathways Choline metabolism in cancer ³⁶	12.42	PDGFRB MAPK1 JUN HIF1A AKT1
13	Toll Comparative Pathway ⁶³ Show member pathways IL-1 Pathway ⁶³ Immune response MIF in innate immunity response ²² iNOS Signaling ⁶³ TLR-TRIF Pathway ⁶³	12.35	TP53 MAPK1 JUN AKT1
14	Development Ligand-independent activation of ESR1 and ESR2 ²² Show member pathways Transcription CREB pathway ²² Transcription PPAR Pathway ²²	12.35	PPARG PDGFRB MAPK1 AKT1
15	Human T-cell leukemia virus 1 infection ³⁶	12.34	TP53 MMP7 MAPK1 JUN AKT1
16	Proteoglycans in cancer ³⁶	12.33	TP53 MAPK1 HIF1A AKT1
17	Circadian rythm related genes ¹	12.29	TP53 SERPINE1 PPARG NAMPT JUN
18	MAPK Signaling: Mitogens ⁶⁴ Show member pathways Akt Signaling Pathway ⁶⁴	12.26	TP53 PDGFRB MAPK1 LMNA AKT1
19	p53 Signaling ⁶³ Show member pathways P53 Pathway ⁶⁶	12.23	TP53 SIRT3 MAPK1 HIF1A AKT1
20	Colorectal Cancer Metastasis ⁶³	12.22	TP53 MMP7 MAPK1 AKT1
21	mTOR Pathway ⁷⁰ Show member pathways Insulin Pathway ⁷⁰ TGF-beta Pathway ⁷⁰	12.21	TP53 PPARG JUN AKT1
22	Cellular senescence (KEGG) ³⁶	12.19	TP53 SERPINE1 MAPK1 AKT1
23	Integrated Breast Cancer Pathway ¹	12.18	TP53 MAPK1 JUN AKT1
24	NGF Pathway ⁶³ Show member pathways TRKA Signaling ⁶³	12.17	TP53 MAPK1 JUN AKT1
25	Development EGFR signaling via small GTPases ²² Show member pathways Development EGFR signaling via PIP3 ²² Development PDGF signaling via MAPK cascades ²² PDGF Pathway ¹	12.16	PDGFRB MAPK1 JUN AKT1
26	UVA-Induced MAPK Signaling ⁶³ Show member pathways UVB-Induced MAPK Signaling ⁶³	12.11	TP53 MAPK1 JUN AKT1
27	TGF-beta Signaling Pathway (WikiPathways) ¹	12.1	TP53 MAPK1 JUN AKT1
28	Direct p53 effectors ¹	12.09	TP63 TP53 SERPINE1 JUN
29	Osteoclast differentiation ³⁶	12.07	PPARG MAPK1 JUN AKT1
30	Longevity regulating pathway ³⁶ Show member pathways Longevity regulating pathway - multiple species ³⁶	12.07	TP53 SOD1 PPARG KL AKT1
31	Thyroid hormone signaling pathway ³⁶	12.05	TP53 MAPK1 HIF1A AKT1
32	S1P3 pathway ¹ Show member pathways S1P1 pathway ¹ S1P2 pathway ¹ S1P4 pathway ¹ S1P5 pathway ¹ Sphingosine 1-phosphate (S1P) pathway ¹	12.02	PDGFRB MAPK1 JUN AKT1
33	G-protein signaling Ras family GTPases in kinase cascades (scheme) ²² Show member pathways Activation of the AP-1 family of transcription factors ⁶⁵ Immune response Oncostatin M signaling via MAPK in human cells ²² MAPK Cascade ¹ Nanoparticle-mediated activation of receptor signaling ¹ Oncostatin M Signaling Pathway ¹	12.02	TP53 SERPINE1 PPARG MAPK1 JUN HIF1A
34	DNA Damage Response (only ATM dependent) ¹	12.01	TP53 MAPK1 JUN AKT1
35	Glioblastoma Multiforme ⁶³	11.99	TP53 PDGFRB MAPK1 AKT1
36	HIF-1 signaling pathway ³⁶	11.98	SERPINE1 MAPK1 HIF1A AKT1
37	Senescence and Autophagy in Cancer ¹	11.96	TP53 SERPINE1 MAPK1 JUN
38	AGE-RAGE signaling pathway in diabetic complications ³⁶	11.93	SERPINE1 MAPK1 JUN AKT1
39	TGF-beta Signaling Pathways ⁶⁴	11.9	PPARG MAPK1 JUN AKT1
40	Adipogenesis ¹	11.89	SERPINE1 PPARG NAMPT LMNA HIF1A
41	Angiogenesis (CST) ⁴	11.87	PDGFRB MMP7 HIF1A
42	IL-6 signaling pathway ¹ Show member pathways IL6-mediated signaling events ¹	11.85	MAPK1 JUN AKT1
43	TP53 Regulates Metabolic Genes ⁶⁵	11.84	TP63 TP53 AKT1
44	LT-BetaR Pathway ⁶³ Show member pathways Apoptosis and survival Lymphotoxin-beta receptor signaling ²²	11.83	MAPK1 JUN AKT1
45	MAPK Signaling: Oxidative Stress ⁶⁴	11.81	TP53 MAPK1 JUN
46	VEGF Pathway (Tocris) ⁶⁰ Show member pathways VEGF Pathway ⁷⁰	11.81	PDGFRB MAPK1 JUN AKT1
47	Glucocorticoid receptor regulatory network ¹	11.8	TP53 MAPK1 JUN AKT1
48	Regulation of nuclear SMAD2/3 signaling ¹	11.79	SERPINE1 JUN AKT1
49	Platinum drug resistance ³⁶	11.77	TP53 MAPK1 AKT1
50	Mitophagy - animal ³⁶	11.74	TP53 JUN HIF1A

Sources

GO Terms for Aging

Cellular components related to Aging according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nucleoplasm	GO:0005654	9.9	WRN TP63 TP53 SOD1 SIRT3 PPARG
2	nucleus	GO:0005634	9.83	WRN TP63 TP53 SOD1 SNCA SIRT3
3	protein-containing complex	GO:0032991	9.28	TP63 TP53 SOD1 SNCA SIRT3 PPARG

Biological processes related to Aging according to GeneCards Suite gene sharing:

(show all 41)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription by RNA polymerase II	GO:0045944	10.15	TP63 TP53 SERPINE1 PPARG NAMPT JUN
2	positive regulation of gene expression	GO:0010628	10.07	TP53 MAPK1 LMNA HIF1A AKT1
3	response to drug	GO:0042493	10	TP53 SOD1 SNCA PPARG JUN
4	positive regulation of transcription, DNA-templated	GO:0045893	9.98	TP63 TP53 PPARG MAPK1 JUN HIF1A
5	negative regulation of neuron apoptotic process	GO:0043524	9.92	SOD1 SNCA JUN HIF1A
6	cellular response to hypoxia	GO:0071456	9.89	TP53 LMNA HIF1A AKT1
7	regulation of signal transduction by p53 class mediator	GO:1901796	9.88	WRN TP63 TP53 AKT1
8	response to oxidative stress	GO:0006979	9.88	WRN TP53 SOD1 AKT1
9	response to organic cyclic compound	GO:0014070	9.87	PPARG PDGFRB NAMPT JUN
10	insulin receptor signaling pathway	GO:0008286	9.86	NAMPT KL AKT1
11	protein import into nucleus	GO:0006606	9.85	TP53 LMNA AKT1
12	negative regulation of protein kinase activity	GO:0006469	9.85	SNCA RGN AKT1
13	positive regulation of endothelial cell proliferation	GO:0001938	9.84	JUN HIF1A AKT1
14	response to nutrient levels	GO:0031667	9.83	SOD1 PPARG MMP7
15	response to estrogen	GO:0043627	9.81	PPARG PDGFRB MAPK1
16	response to hydrogen peroxide	GO:0042542	9.81	SOD1 PDGFRB JUN
17	response to organic substance	GO:0010033	9.81	SOD1 PPARG JUN AKT1
18	circadian rhythm	GO:0007623	9.8	TP53 SERPINE1 NAMPT JUN
19	positive regulation of apoptotic process	GO:0043065	9.8	TP53 SOD1 SNCA PPARG PDGFRB JUN
20	cellular response to reactive oxygen species	GO:0034614	9.78	MAPK1 JUN AKT1
21	microglial cell activation	GO:0001774	9.73	SNCA NAMPT JUN
22	positive regulation of smooth muscle cell proliferation	GO:0048661	9.71	PDGFRB NAMPT JUN AKT1
23	replicative senescence	GO:0090399	9.68	TP53 SERPINE1
24	negative regulation of telomerase activity	GO:0051974	9.67	TP53 PPARG
25	positive regulation of glucose metabolic process	GO:0010907	9.67	RGN AKT1
26	positive regulation of pri-miRNA transcription by RNA polymerase II	GO:1902895	9.67	TP53 PPARG JUN HIF1A
27	cellular response to granulocyte macrophage colony-stimulating factor stimulus	GO:0097011	9.66	MAPK1 AKT1
28	response to fluid shear stress	GO:0034405	9.65	PDGFRB AKT1
29	retina vasculature development in camera-type eye	GO:0061298	9.65	PDGFRB HIF1A
30	negative regulation of reactive oxygen species metabolic process	GO:2000378	9.65	TP53 SIRT3 HIF1A
31	peripheral nervous system myelin maintenance	GO:0032287	9.64	SOD1 AKT1
32	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	GO:0061419	9.63	TP53 HIF1A
33	protein tetramerization	GO:0051262	9.63	TP63 TP53 SNCA
34	replicative cell aging	GO:0001302	9.62	WRN TP63
35	cellular response to cadmium ion	GO:0071276	9.62	SOD1 MAPK1 JUN AKT1
36	positive regulation of superoxide dismutase activity	GO:1901671	9.61	SIRT3 RGN
37	negative regulation of apoptotic process	GO:0043066	9.56	TP53 SOD1 SNCA RGN PDGFRB JUN
38	positive regulation of cell aging	GO:0090343	9.54	TP53 LMNA
39	regulation of thymocyte apoptotic process	GO:0070243	9.52	TP53 HIF1A
40	cell aging	GO:0007569	9.46	WRN TP63 TP53 SOD1
41	aging	GO:0007568	9.44	WRN TP63 SOD1 SNCA SIRT3 RGN

Molecular functions related to Aging according to GeneCards Suite gene sharing:

(show all 13)

#	Name	GO ID	Score	Top Affiliating Genes
1	protein kinase binding	GO:0019901	9.92	TP53 PDGFRB MAPK1 HIF1A AKT1
2	chromatin binding	GO:0003682	9.91	WRN TP63 TP53 PPARG JUN
3	transcription factor binding	GO:0008134	9.8	TP53 PPARG MAPK1 JUN HIF1A
4	zinc ion binding	GO:0008270	9.8	TP53 SOD1 SNCA SIRT3 RGN PPARG
5	transcription regulatory region sequence-specific DNA binding	GO:0000976	9.77	TP63 TP53 SNCA PPARG JUN
6	p53 binding	GO:0002039	9.65	TP63 TP53 HIF1A
7	double-stranded DNA binding	GO:0003690	9.62	TP63 PPARG MAPK1 JUN
8	copper ion binding	GO:0005507	9.61	TP53 SOD1 SNCA
9	identical protein binding	GO:0042802	9.61	TP63 TP53 SOD1 SNCA PPARG NAMPT
10	transcription regulatory region DNA binding	GO:0044212	9.55	TP63 TP53 SNCA PPARG JUN
11	MDM2/MDM4 family protein binding	GO:0097371	9.49	TP63 TP53
12	arachidonic acid binding	GO:0050544	9.46	SNCA PPARG
13	enzyme binding	GO:0019899	9.28	TP53 SOD1 SNCA SIRT3 PPARG PDGFRB

Sources

Sources for Aging

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia

Aging (AGING)

Aliases & Classifications for Aging

MalaCards integrated aliases for Aging:

External Ids:

Summaries for Aging

Related Diseases for Aging

Diseases related to Aging via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Aging:

Symptoms & Phenotypes for Aging

Clinical features from OMIM:

GenomeRNAi Phenotypes related to Aging according to GeneCards Suite gene sharing:

MGI Mouse Phenotypes related to Aging:

Drugs & Therapeutics for Aging

Drugs for Aging (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Genetic Tests for Aging

Anatomical Context for Aging

MalaCards organs/tissues related to Aging:

Publications for Aging

Articles related to Aging:

Genes for Aging

Genes related to Aging (0 elite genes):

Variations for Aging

Expression for Aging

Pathways for Aging

Pathways related to Aging according to GeneCards Suite gene sharing:

GO Terms for Aging

Cellular components related to Aging according to GeneCards Suite gene sharing:

Biological processes related to Aging according to GeneCards Suite gene sharing:

Molecular functions related to Aging according to GeneCards Suite gene sharing:

Sources for Aging