Aliases & Classifications for Aging

MalaCards integrated aliases for Aging:

Name: Aging 57 75

External Ids:

OMIM 57 502000

Summaries for Aging

OMIM : 57 Progressive damage to mitochondrial DNA (mtDNA) during life is thought to contribute to aging processes. This notion is supported by the observation of an aging-related accumulation in human mtDNA of oxidative and alkylation derivatives of nucleotides, of small deletions and insertions, and of large deletions, although their low frequency raises questions about their functional significance (Michikawa et al., 1999). (502000)

MalaCards based summary : Aging is related to atypical werner syndrome and huntington disease. An important gene associated with Aging is BCYRN1 (Brain Cytoplasmic RNA 1), and among its related pathways/superpathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Cellular Senescence (REACTOME). The drugs Phylloquinone and Dexmedetomidine have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and heart, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 75 Senescence (/s?'n?s?ns/) or biological aging is the gradual deterioration of functional characteristics.... more...

Related Diseases for Aging

Diseases related to Aging via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 5810)
# Related Disease Score Top Affiliating Genes
1 atypical werner syndrome 32.9 WRN LMNA
2 huntington disease 32.5 TP53 SOD1 SNCA PPARG AKT1
3 vascular disease 32.1 SOD1 SERPINE1 PPARG NAMPT MAPK1
4 prostate disease 31.9 TP53 PPARG AKT1
5 diabetes mellitus, noninsulin-dependent 31.9 SIRT1 SERPINE1 PPARG NAMPT LMNA AKT1
6 endometrial cancer 31.0 TP53 MAPK1 JUN HIF1A AKT1
7 body mass index quantitative trait locus 11 31.0 SERPINE1 PPARG NAMPT LMNA AKT1
8 ewing sarcoma 30.9 TP53 SIRT1 SERPINE1 PDGFRB MAPK1 JUN
9 overnutrition 30.8 SERPINE1 PPARG NAMPT
10 esophageal cancer 30.7 TP53 JUN HIF1A BCYRN1 AKT1
11 diabetes mellitus 30.6 WRN SOD2 SERPINE1 PPARG NAMPT MAPK1
12 glioblastoma multiforme 30.6 TP53 PPARG PDGFRB MAPK1 HIF1A AKT1
13 endometrial adenocarcinoma 30.5 TP53 HIF1A AKT1
14 prostate cancer 30.5 TP63 TP53 PDGFRB MAPK1 JUN HIF1A
15 nervous system disease 30.5 TP53 SOD1 SNCA AKT1
16 cervical cancer 30.5 TP63 TP53 HIF1A BCYRN1 AKT1
17 ovarian cancer 30.4 TP53 MAPK1 JUN HIF1A BCYRN1 AKT1
18 glucose metabolism disease 30.1 SERPINE1 PPARG AKT1
19 large intestine cancer 30.1 TP53 PPARG JUN HIF1A AKT1
20 squamous cell carcinoma, head and neck 29.4 TP63 TP53 HIF1A AKT1
21 lung cancer susceptibility 3 29.4 TP63 TP53 MAPK1 JUN HIF1A AKT1
22 glioblastoma 29.4 TP53 PPARG PDGFRB MAPK1 HIF1A BCYRN1
23 squamous cell carcinoma 29.3 TP63 TP53 MAPK1 BCYRN1 AKT1
24 lung cancer 28.8 TP63 TP53 PPARG MAPK1 JUN HIF1A
25 macular degeneration, age-related, 1 12.8
26 macular degeneration, age-related, 13 12.5
27 macular degeneration, age-related, 7 12.5
28 neuropathy, hereditary, with or without age-related macular degeneration 12.5
29 macular degeneration, age-related, 2 12.5
30 macular degeneration, age-related, 5 12.5
31 macular degeneration, age-related, 9 12.5
32 macular degeneration, age-related, 8 12.5
33 age-related hearing loss 12.5
34 macular degeneration, age-related, 4 12.5
35 macular degeneration, age-related, 12 12.5
36 macular degeneration, age-related, 14 12.5
37 macular degeneration, age-related, 6 12.5
38 macular degeneration, age-related, 11 12.5
39 macular degeneration, age-related, 15 12.5
40 macular degeneration, age-related, 10 12.5
41 premature aging syndrome, penttinen type 12.5
42 age-related hearing impairment 1 12.4
43 age-related hearing impairment 2 12.4
44 premature aging 12.3
45 short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans 12.3
46 menarche, age at, quantitative trait locus 1 12.3
47 menopause, natural, age at, quantitative trait locus 1 12.3
48 menopause, natural, age at, quantitative trait locus 2 12.3
49 menopause, natural, age at, quantitative trait locus 4 12.3
50 premature aging syndrome, okamoto type 12.3

Graphical network of the top 20 diseases related to Aging:



Diseases related to Aging

Symptoms & Phenotypes for Aging

Clinical features from OMIM:

502000

GenomeRNAi Phenotypes related to Aging according to GeneCards Suite gene sharing:

26 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 10.63 MAPK1
2 Decreased viability GR00221-A-1 10.63 AKT1 MAPK1 PDGFRB PPARG
3 Decreased viability GR00221-A-2 10.63 AKT1 PPARG SOD1 JUN
4 Decreased viability GR00221-A-3 10.63 AKT1 MAPK1 PDGFRB PPARG SOD1 JUN
5 Decreased viability GR00221-A-4 10.63 AKT1 MAPK1 PDGFRB PPARG SOD1
6 Decreased viability GR00231-A 10.63 MAPK1
7 Decreased viability GR00342-S-1 10.63 MAPK1 PDGFRB
8 Decreased viability GR00342-S-2 10.63 MAPK1
9 Decreased viability GR00342-S-3 10.63 MAPK1
10 Decreased viability GR00402-S-2 10.63 AKT1 MAPK1 PDGFRB PPARG SOD1 JUN
11 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.8 AKT1 HIF1A JUN SIRT1 SNCA SOD1
12 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.8 AKT1 HIF1A JUN SIRT1 SNCA SOD1
13 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.5 HIF1A JUN SIRT1 SOD1 TP53 TP63

MGI Mouse Phenotypes related to Aging:

46 (show all 27)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.58 AKT1 HIF1A JUN KL LMNA MAPK1
2 growth/size/body region MP:0005378 10.54 AKT1 HIF1A JUN KL LMNA MAPK1
3 cellular MP:0005384 10.52 AKT1 HIF1A JUN KL LMNA MAPK1
4 homeostasis/metabolism MP:0005376 10.51 AKT1 HIF1A JUN KL LMNA MAPK1
5 behavior/neurological MP:0005386 10.5 AKT1 HIF1A JUN KL LMNA MAPK1
6 immune system MP:0005387 10.5 AKT1 HIF1A JUN KL LMNA MAPK1
7 endocrine/exocrine gland MP:0005379 10.47 AKT1 HIF1A JUN KL LMNA MAPK1
8 integument MP:0010771 10.47 AKT1 HIF1A JUN KL LMNA MAPK1
9 mortality/aging MP:0010768 10.45 AKT1 HIF1A JUN KL LMNA MAPK1
10 hematopoietic system MP:0005397 10.44 AKT1 HIF1A JUN KL LMNA MAPK1
11 adipose tissue MP:0005375 10.37 AKT1 KL LMNA PDGFRB PPARG SERPINE1
12 liver/biliary system MP:0005370 10.32 AKT1 HIF1A JUN KL LMNA MAPK1
13 digestive/alimentary MP:0005381 10.3 HIF1A KL LMNA MAPK1 PDGFRB SIRT1
14 embryo MP:0005380 10.3 AKT1 HIF1A JUN MAPK1 NAMPT PDGFRB
15 nervous system MP:0003631 10.28 AKT1 HIF1A JUN KL LMNA MAPK1
16 craniofacial MP:0005382 10.26 HIF1A KL LMNA MAPK1 PDGFRB SIRT1
17 muscle MP:0005369 10.22 AKT1 HIF1A KL LMNA MAPK1 PDGFRB
18 neoplasm MP:0002006 10.2 AKT1 HIF1A MAPK1 PPARG SERPINE1 SIRT1
19 limbs/digits/tail MP:0005371 10.13 HIF1A KL LMNA PDGFRB SIRT1 TP53
20 hearing/vestibular/ear MP:0005377 10.12 KL LMNA MAPK1 PPARG SOD1 SOD2
21 normal MP:0002873 10.11 AKT1 HIF1A JUN LMNA PDGFRB PPARG
22 reproductive system MP:0005389 10.07 AKT1 KL LMNA MAPK1 PDGFRB PPARG
23 renal/urinary system MP:0005367 10.06 HIF1A KL LMNA PDGFRB PPARG SERPINE1
24 no phenotypic analysis MP:0003012 9.95 JUN PPARG SIRT1 SIRT3 SNCA TP53
25 respiratory system MP:0005388 9.85 AKT1 HIF1A JUN KL LMNA MAPK1
26 skeleton MP:0005390 9.77 AKT1 HIF1A JUN KL LMNA MAPK1
27 vision/eye MP:0005391 9.44 HIF1A JUN KL LMNA MAPK1 PDGFRB

Drugs & Therapeutics for Aging

Drugs for Aging (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 938)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Phylloquinone Approved, Investigational Phase 4 84-80-0
2
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
3
Darunavir Approved Phase 4 206361-99-1, 635728-49-3 213039
4
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
5
Esmolol Approved Phase 4 103598-03-4, 81147-92-4 59768
6
Remifentanil Approved Phase 4 132875-61-7 60815
7
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
8
Dalteparin Approved Phase 4 9005-49-6
9
Pantoprazole Approved Phase 4 102625-70-7 4679
10
Cisatracurium Approved Phase 4 96946-41-7
11 fluindione Approved, Investigational Phase 4 957-56-2
12
Cobicistat Approved Phase 4 1004316-88-4
13
Rilpivirine Approved Phase 4 500287-72-9
14
Ticlopidine Approved Phase 4 55142-85-3 5472
15
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
16
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
17
Polyestradiol phosphate Approved Phase 4 28014-46-2
18
Perindopril Approved Phase 4 107133-36-8, 82834-16-0 107807
19
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
20
Lisinopril Approved, Investigational Phase 4 83915-83-7, 76547-98-3 5362119
21
Enalapril Approved, Vet_approved Phase 4 75847-73-3 5362032 40466924
22
Enalaprilat Approved Phase 4 76420-72-9 6917719
23
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
24
Ritonavir Approved, Investigational Phase 4 155213-67-5 392622
25
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
26
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492 6473866
27
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
28
Menthol Approved Phase 4 2216-51-5 16666
29
Norepinephrine Approved Phase 4 51-41-2 439260
30
Heparin Approved, Investigational Phase 4 9005-49-6 46507594 772
31
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
32
Clopidogrel Approved Phase 4 113665-84-2, 120202-66-6 60606
33
Eszopiclone Approved, Investigational Phase 4 138729-47-2 969472
34
Simvastatin Approved Phase 4 79902-63-9 54454
35
Olmesartan Approved, Investigational Phase 4 144689-63-4, 144689-24-7 130881 158781
36
Nebivolol Approved, Investigational Phase 4 152520-56-4, 118457-14-0, 99200-09-6 71301
37
Quinapril Approved, Investigational Phase 4 85441-61-8 54892
38
Spirapril Approved Phase 4 83647-97-6 5311447
39
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
40
Indapamide Approved Phase 4 26807-65-8 3702
41
Atenolol Approved Phase 4 29122-68-7 2249
42
Doxazosin Approved Phase 4 74191-85-8 3157
43
Aminosalicylic Acid Approved Phase 4 65-49-6 4649
44
Cimetidine Approved, Investigational Phase 4 51481-61-9 2756
45
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
46
Desflurane Approved Phase 4 57041-67-5 42113
47
Sofosbuvir Approved Phase 4 1190307-88-0 45375808
48
Ledipasvir Approved Phase 4 1256388-51-8 67505836
49
Mupirocin Approved, Investigational, Vet_approved Phase 4 12650-69-0 446596
50
Mirabegron Approved Phase 4 223673-61-8 9865528

Interventional clinical trials:

(show top 50) (show all 3443)
# Name Status NCT ID Phase Drugs
1 Different Doses Rosuvastatin Effect on Telomere-telomerase System in Acute Coronary Syndrome Patients After Percutaneous Coronary INtervention: RETAIN Study Unknown status NCT02299245 Phase 4 rosuvastatin
2 Medication Induced Blood Pressure Reduction; Assessment of Cerebral Perfusion and Cognition in Hypertensive Elderly Unknown status NCT00966199 Phase 4 anti-hypertensive medication
3 Outcome Comparison Between PFNA and InterTAN in Intertrochanteric Fractures Unknown status NCT01797237 Phase 4
4 The Effect of Dexmedetomidine on Postoperative Recovery in Elderly Patients With Femoral Neck Fracture Undergoing Hip Hemi-arthroplasty Unknown status NCT01934049 Phase 4 Total Intravenous Anesthesia and Peripheral nerve blocks
5 Evaluation of Cholecalciferol Supplementation in Chronic Kidney Disease Patients With Restless Leg Syndrome Unknown status NCT03063190 Phase 4 Vitamin D;Placebo Oral Tablet
6 Can Methylphenidate (Ritalin) Improve Memory and Attention in Mild Cognitive Impairment? A Combined Behaviour-EEG Study Unknown status NCT02326038 Phase 4 Methylphenidate
7 Phase 4 Study of Long Term Postoperative Cognitive Dysfunction After Laparoscopic Cholecystectomy in the Elderly Patients Unknown status NCT02301676 Phase 4 Sevoflurane;propofol
8 An Open-Label Pilot Study to Compare the Efficacy of Escalating Doses of IncobotulinumtoxinA (Xeomin®) in the Treatment of Glabellar Rhytids Unknown status NCT01583478 Phase 4
9 Treatment of Intertrochanteric Fracture With New Type of Intramedullary Nail Unknown status NCT01437176 Phase 4
10 A Randomised, Placebo Controlled, Double Blind, Cross-over, Single Center Clinical Study to Investigate the Effect of Heart Rate Reduction With Ivabradine on Vascular Elastic Properties and Endothelial Function in Patients With Stable Coronary Heart Disease Unknown status NCT01768585 Phase 4 Ivabradine;Placebo
11 Group Mindfulness-Based Cognitive Therapy for the Treatment of Late-Life Depression and Anxiety Symptoms in Primary Care: A Randomized Controlled Trial Unknown status NCT02777905 Phase 4
12 Frailty and Cognitive Function Assessment of TAVI Patients (The Hungarian Frailty Score) - Observational, Prospective, Singe Center Study Unknown status NCT02650388 Phase 4
13 Multi-Centre, Prospective, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Vardenafil in Men With Erectile Dysfunction Caused by Spinal Cord Injury Unknown status NCT00725790 Phase 4 Vardenafil;Placebo
14 CHADSS: Chagas Disease Scan Study Unknown status NCT01650792 Phase 4 Aspirin
15 Does Early Re-administration of Aspirin/Clopidogrel Increase the Risk of Bleeding From Artificial Ulcer After EMR or ESD? Unknown status NCT01621451 Phase 4 aspirin and/or clopidogrel;aspirin and/or clopidogrel
16 The Efficacy and Optimal Dose of Sufentanil in Patient Controlled Analgesia After Moderate Surgery Unknown status NCT02503826 Phase 4 Sufentanil;Sufentanil;Sufentanil;Midazolam;propofol;cisatracurium
17 The VICTORIA Study (Vascular CalcIfiCation and sTiffness Induced by ORal antIcoAgulation) Comparison Anti-vitamin K Versus Anti-Xa. Unknown status NCT02161965 Phase 4 Rivaroxaban;Fluindione;Warfarin
18 The Effect of a Higher Dose of Dehydroepiandrosterone (DHEA) Supplementation on the Number of Oocytes Obtained During IVF in Poor Ovarian Responders Unknown status NCT02357472 Phase 4 dehydroepiandrosterone
19 Effects of a Chronical Treatment With Benfotiamine in People With Type 2 Diabetes Mellitus on Pre- and Postprandial Endothelial Function, as Well as on the Function of the Autonomic Nervous System Unknown status NCT00446810 Phase 4 Benfotiamine;Placebo
20 A PROSPECTIVE, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF THE SUPPLEMENTATION WITH KIOLIC® IN PATIENTS WITH DIAGNOSIS OF METABOLIC SYNDROME TO IMPROVE ENDOTHELIAL FUNCTION AND INFLAMMATORY STATE. "KYMES" Unknown status NCT01168700 Phase 4 aged garlic extract;Placebo
21 A Phase IV 48 Week, Open Label, Pilot Study of Darunavir Boosted by Cobicistat in Combination With Rilpivirine to Treat HIV+ Naïve Subjects (PREZENT) Unknown status NCT02404233 Phase 4 darunavir/cobicistat;rilpivirine
22 Effect of Controlled Hypotension on Cerebral Oxygen Saturation in Patients Undergoing Functional Endoscopic Sinus Surgery: a Prospective Randomized Single Blind Clinical Trial Unknown status NCT02967029 Phase 4 Esmolol Hydrochloride;Remifentanil Hydrochloride
23 The Effect on an Ionic Silver Dressing in Head and Neck Patients With Malignant Fungating Wound Unknown status NCT00813631 Phase 4
24 Ejaculatory Sparing vs. Non-ejaculatory Sparing GreenLightTM Laser Photoselective Vaporization of the Prostate (PVP): A Randomized Double Blind Sexual and Urodynamic Assessment Unknown status NCT02749604 Phase 4
25 Endovascular Treatment Versus Optimal Medical Treatment of Atherosclerotic Renal Artery for Preserving Renal Function of the Ischemic Kidney. Unknown status NCT01208714 Phase 4 Optimal medical therapy
26 Randomized Study Comparing Switching to Raltegravir-based Antiretroviral Versus Maintaining Any Other Antiretroviral Therapy in HIV Monoinfected Patients Impact on Fatty Liver and Liver Fibrosis Assessed by Noninvasive Diagnostic Methods Unknown status NCT02210715 Phase 4 Isentress.
27 Discovery of Effects of Retinol on Human Skin Aging in Individuals of East Asian Descent Completed NCT02906566 Phase 4 Retinol;Placebo
28 Metformin in Longevity Study (MILES). Completed NCT02432287 Phase 4 Metformin;Placebo
29 Physiologic Effects of PRMS & Testosterone in the Debilitated Elderly Completed NCT00018356 Phase 4 testosterone
30 Genomic Outcomes of Metformin Completed NCT02986659 Phase 4 Metformin;Placebo
31 Multi-parameter Immune Profile Associated With the Humoral Response to Influenza Vaccine, Vaxigrip® in Healthy and Frail Elderly Subjects Aged 65-90 Years in Singapore Completed NCT03266237 Phase 4 Vaxigrip®
32 hCG Priming Prior to COH in Poor Responder IVF Patients Completed NCT00870025 Phase 4
33 Aging White Matter Changes, Executive Dysfunction and Depression Completed NCT00918684 Phase 4 Escitalopram
34 The Effects of Pectin on Aging-related Changes in Intestinal Barrier Function, Immune Function and Microbial Composition Completed NCT02376270 Phase 4
35 Patient Satisfaction With Treatment of BOTOX® Cosmetic for the Temporary Correction of Moderate to Severe Glabellar Lines Completed NCT00856414 Phase 4
36 A Comparative Randomized Double-Blinded Study of the Effect of Dysport and Botox on Forehead Wrinkles and EMG Activity Completed NCT00434863 Phase 4 botulinum toxin type A
37 Canadian Study of the Use of Injectable POLY-L-LACTIC Acid (Sculptra Therapy) in Aesthetic Medicine Completed NCT00447551 Phase 4 Poly-L-Lactic Acid
38 Volume Restoration of the Aging Midface With Sculptra Aesthetic Completed NCT01307865 Phase 4 injectable poly-L-lactic acid
39 A Phase IV, Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Single-Center Study on the Effects of a Proprietary Blend of Herbal Extract Supplement on Cellular Detoxification, Inflammation, and Cumulative Cognitive Index as Well as Gene Expression in Middle-Aged Adult Women. Completed NCT01598272 Phase 4
40 Immunogenicity of Pneumococcal Vaccination and Revaccination in Older Adults Completed NCT00239694 Phase 4
41 Clinical Evaluation of Day and Night Skin Care Creams Supplemented With MediCell Technology (MCT)'s Composition of Defensins and Supportive Molecules Completed NCT02765763 Phase 4 2-Minute Reveal Masque;24/7 Barrier Repair Cream;8-in-1 BioSerum;Null Formula 2-Minute Reveal Masque;Null Formula 24/7 Barrier Repair Cream;Null Formula 8-in-1 BioSerum
42 Split-face Study of Changing in Skin Physiology and Clinical Appearance After Microdroplet Placement of Stabilized Hyaluronic Acid in Aging Faces Completed NCT02312154 Phase 4
43 Randomized, Controlled, Multi-Centered, Double-Blind Investigation of Injectable Poly-L-Lactic Acid (Sculptra Aesthetic) for Improving Facial Wrinkles and Skin Quality Completed NCT02003833 Phase 4
44 A Prospective, Open Label, Randomized, Comparative, Split-Face Study Evaluating Reconstituted JUVÉDERM® Ultra Injectable Gel Versus COSMODERM® 1 Human Based Collagen Implant for the Treatment of Vertical Lip Rhytids and Radial Cheek Lines Completed NCT01212809 Phase 4
45 Effects of DHEA/Exercise on Bone, Muscle and Balance Completed NCT00664053 Phase 4
46 Memory and Mental Health in Aging: Psychopharmacological Augmentation of Memory Training in Older Adults Completed NCT02988908 Phase 4 Donepezil;Placebos
47 Efficacy and Safety of a Mixed Extract of Fenugreek Seed and Lespedeza Cuneata in the Treatment of Testosterone Deficiency Syndrome: A Randomized, Double-blind, Placebo-Controlled Clinical Trial Completed NCT03057899 Phase 4 TFG capsules (200 mg /capsule);Placebo oral capsule
48 Mechanisms of Immune Reconstitution & Reduced Immune Activation Following Darunavir-based ART Completed NCT01869634 Phase 4 darunavir with ritonavir and fixed-dose viread+emtricitabine daily
49 Oral Administration of L-Arginine in Patients With Erectile Dysfunction Completed NCT00777075 Phase 4 L-arginine;Placebo
50 Preventing Delirium in Hospitalized Elderly Completed NCT00182884 Phase 4 Donepezil

Search NIH Clinical Center for Aging

Genetic Tests for Aging

Anatomical Context for Aging

MalaCards organs/tissues related to Aging:

41
Brain, Skin, Heart, Bone, Skeletal Muscle, Kidney, Testes

Publications for Aging

Articles related to Aging:

(show top 50) (show all 30012)
# Title Authors PMID Year
1
Short telomeres are sufficient to cause the degenerative defects associated with aging. 38 8
19944403 2009
2
Lamin A-dependent nuclear defects in human aging. 38 8
16645051 2006
3
Genome dynamics in aging mice. 38 8
12421760 2002
4
Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication. 38 8
10531063 1999
5
Accumulation of deletions in human mitochondrial DNA during normal aging: analysis by quantitative PCR. 38 8
1463763 1992
6
Mitochondrial genetics: a paradigm for aging and degenerative diseases? 38 8
1533953 1992
7
Increased cell-to-cell variation in gene expression in ageing mouse heart. 8
16791200 2006
8
Gene regulation and DNA damage in the ageing human brain. 8
15190254 2004
9
Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes. 8
12538859 2003
10
Mitochondrial DNA polymorphisms associated with longevity in a Finnish population. 8
12483296 2003
11
Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication. 8
11274426 2001
12
Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine. 8
10900004 2000
13
Role of nuclear background and in vivo environment in variable segregation behavior of the aging-dependent T414G mutation at critical control site for human fibroblast mtDNA replication. 8
15328912 1999
14
Mitochondrial genotype associated with longevity. 8
9449878 1998
15
Growing old: the most common mitochondrial disease of all? 8
1303273 1992
16
Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain. 8
1303287 1992
17
Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age. 8
1303288 1992
18
Evidence for and against the causal involvement of mitochondrial DNA mutation in mammalian ageing. 8
1383763 1992
19
Effect of Step Quenching on Multi-Step Aging Behavior in Al-Mg-Si Alloys. 38
31383207 2020
20
Differentiating between Alzheimer's disease, amnestic mild cognitive impairment, and normal aging via diffusion kurtosis imaging. 38
31397353 2019
21
Aging-associated microstructural deterioration of vertebra in zebrafish. 38
31388517 2019
22
Effect of aerobic exercise on white matter microstructure in the aging brain. 38
31279793 2019
23
Effect of different dry aging temperatures on Listeria innocua as surrogate for Listeria monocytogenes. 38
31323452 2019
24
Novel adenoviral IGF-1 administration modulates the association between depressive symptoms and aging: Does gender matter? 38
31229647 2019
25
The functional interaction of the brain default network with motor networks is modified by aging. 38
31288062 2019
26
How do aging and comorbidities impact risk of ischemic stroke in patients with atrial fibrillation. 38
30446380 2019
27
Sex difference in CHI3L1 expression levels in human brain aging and in Alzheimer's disease. 38
31247206 2019
28
Aging, lifestyle and dementia. 38
31136814 2019
29
Hallmarks of senescence and aging. 38
31379458 2019
30
Reciprocal relationships between the will-to-live and successful aging. 38
30450948 2019
31
Dimensions of Religious Involvement Represent Positive Pathways in Cognitive Aging. 38
31303123 2019
32
The Aging Thyroid: A Reappraisal Within the Geroscience Integrated Perspective. 38
31074798 2019
33
Human aging DNA methylation signatures are conserved but accelerated in cultured fibroblasts. 38
31156022 2019
34
Seasonal modification of the associations of exposure to polycyclic aromatic hydrocarbons or phthalates of cellular aging. 38
31272023 2019
35
Aging in the Syrian hamster testis: Inflammatory-oxidative status and the impact of photoperiod. 38
31276778 2019
36
Aging-induced elevation in circulating complement C1q level is associated with arterial stiffness. 38
31279001 2019
37
Theory of mind, mental state talk and social relationships in aging: The case of friendship. 38
30482047 2019
38
In search of nutritional anti-aging targets: TOR inhibitors, SASP modulators, and BCL-2 family suppressors. 38
31029919 2019
39
Detrimental links between physical inactivity, metabolic risk and N-glycomic biomarkers of aging. 38
31158451 2019
40
Association Between Pancreatic Cystic Lesions and High-grade Intraepithelial Neoplasia and Aging: An Autopsy Study. 38
31404026 2019
41
Towards understanding neural network signatures of motor skill learning in Parkinson's disease and healthy aging. 38
30982328 2019
42
Effects of aging on sequential cognitive flexibility are associated with fronto-parietal processing deficits. 38
31218393 2019
43
Is aspiration and sclerotherapy treatment for hydroceles in the aging male an evidence-based treatment? 38
29336195 2019
44
Numeracy Skills and Self-Reported Mental Health in People Aging Well. 38
31222690 2019
45
Detrimental Effects of Psychotropic Medications Differ by Sex in Aging People With HIV. 38
31169770 2019
46
SIRT2 functions in aging, autophagy, and apoptosis in post-maturation bovine oocytes. 38
31295472 2019
47
A model of brain morphological changes related to aging and Alzheimer's disease from cross-sectional assessments. 38
31121298 2019
48
Exosomal Notch3 from high glucose-stimulated endothelial cells regulates vascular smooth muscle cells calcification/aging. 38
31220525 2019
49
Altered functions of platelets during aging. 38
31348047 2019
50
Accelerated aging in serious mental disorders. 38
31145144 2019

Variations for Aging

Expression for Aging

Search GEO for disease gene expression data for Aging.

Pathways for Aging

Pathways related to Aging according to GeneCards Suite gene sharing:

(show top 50) (show all 91)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.61 TP53 SOD2 SOD1 SNCA PPARG MAPK1
2
Show member pathways
13.18 TP53 SOD2 SOD1 SIRT1 MAPK1 JUN
3
Show member pathways
12.91 TP53 PPARG PDGFRB MAPK1 JUN AKT1
4
Show member pathways
12.84 TP63 TP53 MAPK1 LMNA JUN AKT1
5 12.81 TP53 PDGFRB MAPK1 JUN AKT1
6 12.78 TP53 PPARG PDGFRB MAPK1 JUN HIF1A
7
Show member pathways
12.77 TP53 PDGFRB MAPK1 KL AKT1
8
Show member pathways
12.74 TP53 PDGFRB MAPK1 JUN AKT1
9
Show member pathways
12.63 TP53 MAPK1 JUN HIF1A AKT1
10 12.57 TP63 TP53 SIRT1 PDGFRB MAPK1
11
Show member pathways
12.57 TP53 SIRT3 SIRT1 PDGFRB MAPK1 JUN
12 12.51 SOD2 SIRT3 SIRT1 PPARG NAMPT AKT1
13
Show member pathways
12.49 TP53 PDGFRB JUN AKT1
14 12.47 TP53 MAPK1 JUN AKT1
15
Show member pathways
12.46 TP53 SIRT1 PPARG MAPK1 AKT1
16
Show member pathways
12.43 PDGFRB MAPK1 JUN HIF1A AKT1
17 12.4 TP53 PDGFRB JUN AKT1
18
Show member pathways
12.38 TP53 SOD2 SOD1 SERPINE1
19
Show member pathways
12.36 PPARG PDGFRB MAPK1 AKT1
20
Show member pathways
12.35 TP53 MAPK1 JUN AKT1
21 12.34 TP53 MAPK1 HIF1A AKT1
22
Show member pathways
12.28 SIRT1 SERPINE1 NAMPT HIF1A
23
Show member pathways
12.24 TP53 PDGFRB MAPK1 LMNA AKT1
24
Show member pathways
12.22 TP53 PPARG JUN AKT1
26
Show member pathways
12.19 TP53 MAPK1 JUN AKT1
27
Show member pathways
12.19 PDGFRB MAPK1 JUN AKT1
28 12.18 TP53 PDGFRB LMNA AKT1
29 12.17 TP53 SIRT1 SERPINE1 MAPK1 AKT1
30
Show member pathways
12.14 SOD2 SIRT1 MAPK1 AKT1
31 12.14 TP53 SIRT1 MAPK1 JUN AKT1
32 12.12 TP53 MAPK1 JUN AKT1
33
Show member pathways
12.12 TP53 SIRT3 SIRT1 MAPK1 HIF1A AKT1
34 12.11 TP63 TP53 SERPINE1 JUN
35
Show member pathways
12.1 TP53 MAPK1 JUN AKT1
36 12.09 PPARG MAPK1 JUN AKT1
37
Show member pathways
12.06 TP53 SERPINE1 PPARG MAPK1 JUN HIF1A
38 12.05 TP53 MAPK1 HIF1A AKT1
39
Show member pathways
12.03 PDGFRB MAPK1 JUN AKT1
40 12.01 TP53 PDGFRB MAPK1 AKT1
41 12 SERPINE1 PPARG NAMPT LMNA HIF1A
42 11.98 SERPINE1 MAPK1 HIF1A AKT1
43 11.97 TP53 SERPINE1 MAPK1 JUN
44 11.93 SERPINE1 MAPK1 JUN AKT1
45 11.92 TP53 SOD2 MAPK1 JUN AKT1
46
Show member pathways
11.91 MAPK1 HIF1A AKT1
47
Show member pathways
11.91 SOD1 MAPK1 JUN
48 11.9 SIRT1 JUN AKT1
49 11.9 PPARG MAPK1 JUN AKT1
50
Show member pathways
11.88 TP53 SOD2 SOD1 SIRT1 PPARG KL

GO Terms for Aging

Cellular components related to Aging according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.9 WRN TP63 TP53 SOD1 SIRT1 PPARG
2 mitochondrial matrix GO:0005759 9.65 TP53 SOD2 SOD1 SNCA SIRT3
3 nuclear chromatin GO:0000790 9.62 TP63 TP53 SIRT1 JUN
4 mitochondrion GO:0005739 9.61 TP63 TP53 SOD2 SOD1 SNCA SIRT3
5 protein-containing complex GO:0032991 9.23 TP63 TP53 SOD1 SIRT3 PPARG MAPK1
6 nucleus GO:0005634 10.21 WRN TP63 TP53 SOD1 SNCA SIRT1

Biological processes related to Aging according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Name GO ID Score Top Affiliating Genes
1 regulation of apoptotic process GO:0042981 9.98 WRN TP63 TP53 SIRT1 AKT1
2 response to oxidative stress GO:0006979 9.92 WRN SOD1 SIRT1 AKT1
3 response to organic cyclic compound GO:0014070 9.92 PPARG PDGFRB NAMPT JUN
4 rhythmic process GO:0048511 9.9 TP53 SIRT1 PPARG NAMPT
5 cellular response to oxidative stress GO:0034599 9.89 SOD2 SOD1 SNCA
6 insulin receptor signaling pathway GO:0008286 9.88 NAMPT KL AKT1
7 regulation of signal transduction by p53 class mediator GO:1901796 9.88 TP63 TP53 AKT1
8 protein homotetramerization GO:0051289 9.87 TP63 TP53 SOD2
9 response to estrogen GO:0043627 9.86 PPARG PDGFRB MAPK1
10 response to organic substance GO:0010033 9.86 SOD1 PPARG JUN AKT1
11 negative regulation of apoptotic process GO:0043066 9.86 TP53 SOD1 SNCA SIRT1 PDGFRB JUN
12 regulation of blood pressure GO:0008217 9.85 SOD2 SOD1 PPARG
13 circadian rhythm GO:0007623 9.85 SIRT1 SERPINE1 NAMPT JUN
14 negative regulation of neuron death GO:1901215 9.83 SNCA SIRT1 AKT1
15 negative regulation of neuron apoptotic process GO:0043524 9.83 SOD2 SOD1 SNCA JUN HIF1A
16 positive regulation of blood vessel endothelial cell migration GO:0043536 9.82 SIRT1 HIF1A AKT1
17 positive regulation of endothelial cell proliferation GO:0001938 9.81 SIRT1 JUN HIF1A AKT1
18 cellular response to reactive oxygen species GO:0034614 9.79 MAPK1 JUN AKT1
19 positive regulation of smooth muscle cell proliferation GO:0048661 9.78 PDGFRB NAMPT JUN AKT1
20 cellular response to ionizing radiation GO:0071479 9.77 TP53 SIRT1 NAMPT
21 cellular response to hypoxia GO:0071456 9.77 TP53 SIRT1 LMNA HIF1A AKT1
22 response to hydrogen peroxide GO:0042542 9.76 SOD1 SIRT1 PDGFRB JUN
23 positive regulation of apoptotic process GO:0043065 9.76 TP53 SOD1 SNCA SIRT1 PPARG PDGFRB
24 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.75 TP53 JUN HIF1A
25 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.74 TP63 TP53 SIRT1
26 white fat cell differentiation GO:0050872 9.72 SIRT1 PPARG
27 replicative senescence GO:0090399 9.72 TP53 SERPINE1
28 removal of superoxide radicals GO:0019430 9.72 SOD2 SOD1
29 protein deacetylation GO:0006476 9.71 SIRT3 SIRT1
30 positive regulation of vascular associated smooth muscle cell apoptotic process GO:1905461 9.71 SOD2 PPARG
31 negative regulation of telomerase activity GO:0051974 9.71 TP53 PPARG
32 microglial cell activation GO:0001774 9.71 SNCA NAMPT JUN
33 DNA synthesis involved in DNA repair GO:0000731 9.7 WRN SIRT1
34 response to fluid shear stress GO:0034405 9.69 PDGFRB AKT1
35 cellular response to granulocyte macrophage colony-stimulating factor stimulus GO:0097011 9.68 MAPK1 AKT1
36 retina vasculature development in camera-type eye GO:0061298 9.68 PDGFRB HIF1A
37 peripheral nervous system myelin maintenance GO:0032287 9.67 SOD1 AKT1
38 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176 9.67 SOD2 SIRT1 AKT1
39 peptidyl-lysine deacetylation GO:0034983 9.66 SIRT3 SIRT1
40 oxygen homeostasis GO:0032364 9.66 SOD2 HIF1A
41 response to superoxide GO:0000303 9.65 SOD2 SOD1
42 replicative cell aging GO:0001302 9.64 WRN TP63
43 cellular response to cadmium ion GO:0071276 9.62 SOD1 MAPK1 JUN AKT1
44 negative regulation of helicase activity GO:0051097 9.61 TP53 SIRT1
45 cell aging GO:0007569 9.35 WRN TP63 TP53 SOD1 SIRT1
46 aging GO:0007568 9.32 WRN TP63 SOD1 SNCA SIRT3 PDGFRB
47 negative regulation of transcription by RNA polymerase II GO:0000122 10.17 TP63 TP53 SNCA SIRT1 PPARG JUN
48 apoptotic process GO:0006915 10.13 TP63 TP53 SNCA SIRT1 MAPK1 AKT1
49 cell differentiation GO:0030154 10.11 TP63 TP53 SIRT1 PPARG HIF1A AKT1
50 positive regulation of cell proliferation GO:0008284 10.1 SIRT1 PDGFRB NAMPT MAPK1 JUN AKT1

Molecular functions related to Aging according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.89 TP53 PDGFRB MAPK1 HIF1A AKT1
2 chromatin binding GO:0003682 9.88 WRN TP63 TP53 PPARG JUN
3 protein domain specific binding GO:0019904 9.81 TP63 SNCA SIRT1 HIF1A
4 transcription factor binding GO:0008134 9.73 TP53 SIRT1 PPARG MAPK1 JUN HIF1A
5 transcription regulatory region DNA binding GO:0044212 9.72 TP63 TP53 SNCA PPARG JUN
6 identical protein binding GO:0042802 9.7 TP63 TP53 SOD2 SOD1 SNCA SIRT1
7 copper ion binding GO:0005507 9.63 TP53 SOD1 SNCA
8 p53 binding GO:0002039 9.46 TP63 TP53 SIRT1 HIF1A
9 superoxide dismutase activity GO:0004784 9.4 SOD2 SOD1
10 NAD-dependent histone deacetylase activity GO:0017136 9.37 SIRT3 SIRT1
11 enzyme binding GO:0019899 9.32 TP53 SOD1 SNCA SIRT3 SIRT1 PPARG
12 NAD-dependent protein deacetylase activity GO:0034979 9.13 SIRT1

Sources for Aging

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
Content
Loading form....