Aliases & Classifications for Agraphia

Summaries for Agraphia

Disease Ontology : 12 An acquired writing disorder causing a loss in the ability to communicate through writing, either due to some motor dysfunction or the inability to spell.

MalaCards based summary : Agraphia is related to progressive non-fluent aphasia and alexia, and has symptoms including other symbolic dysfunction An important gene associated with Agraphia is MAPT (Microtubule Associated Protein Tau), and among its related pathways/superpathways are Spinal Cord Injury and Neuroscience. The drugs tannic acid and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and occipital lobe, and related phenotypes are Decreased viability with paclitaxel and hematopoietic system

Wikipedia : 76 Agraphia is an acquired neurological disorder causing a loss in the ability to communicate through... more...

Related Diseases for Agraphia

Diseases related to Agraphia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Related Disease Score Top Affiliating Genes
1 progressive non-fluent aphasia 31.9 GRN MAPT PSEN1
2 alexia 31.1 KANTR MBP PPP3CA PSEN1 TARDBP
3 aphasia 30.7 GRN MAPT PRNP PSEN1
4 apraxia 30.7 GRN MAPT PSEN1
5 frontotemporal lobar degeneration with tdp43 inclusions, grn-related 30.3 GRN MAPT
6 dementia 30.2 ACHE BCHE GRN MAPT PRNP PSEN1
7 nominal aphasia 30.2 GRN MAPT PSEN1 TARDBP
8 alzheimer disease 30.1 ACHE BCHE GRN MAPT PRNP PSEN1
9 prosopagnosia 30.0 GRN PSEN1
10 semantic dementia 29.9 GRN MAPT PSEN1 TARDBP
11 amyotrophic lateral sclerosis 1 29.9 CDR1 GRN MAPT PRNP PSEN1 TARDBP
12 frontotemporal dementia 29.8 ACHE GRN MAPT PRNP PSEN1 TARDBP
13 ideomotor apraxia 29.8 CBS GRN MAPT MBP
14 supranuclear palsy, progressive, 1 29.6 ACHE CBS GRN MAPT PSEN1 TARDBP
15 dysgraphia 11.7
16 gerstmann syndrome 11.3
17 inclusion body myopathy with early-onset paget disease and frontotemporal dementia 11.1
18 expressive language disorder 10.2 PSEN1 TARDBP
19 behavioral variant of frontotemporal dementia 10.2 GRN MAPT PSEN1
20 phonagnosia 10.2 GRN PSEN1 TARDBP
21 associative agnosia 10.2 GRN PSEN1 TARDBP
22 writing disorder 10.2 GRN PSEN1 TARDBP
23 akinetic mutism 10.2 MAPT PRNP
24 familial idiopathic basal ganglia calcification 10.2 MAPT PSEN1
25 butyrylcholinesterase deficiency 10.2 ACHE BCHE
26 gait apraxia 10.2 CBS GRN PSEN1
27 kohlschutter-tonz syndrome 10.1 MAPT PSEN1
28 alzheimer disease 2 10.1 BCHE MAPT PSEN1
29 amnestic disorder 10.1 ACHE BCHE PSEN1
30 pick disease of brain 10.1 GRN MAPT PSEN1 TARDBP
31 cerebral amyloid angiopathy, cst3-related 10.1 MAPT PRNP PSEN1
32 multiple sclerosis 10.1
33 lateral sclerosis 10.1
34 marchiafava bignami disease 10.1
35 disease of mental health 10.1 GRN MAPT PSEN1 TARDBP
36 kluver-bucy syndrome 10.1 MAPT PSEN1
37 echolalia 10.1 CBS GRN MAPT PSEN1
38 cicatricial ectropion 10.1 CBS KANTR
39 postencephalitic parkinson disease 10.1 KANTR MAPT TARDBP
40 glomangiosarcoma 10.1 KANTR TP53
41 visual agnosia 10.1 GRN KANTR PSEN1
42 cerebrovascular disease 10.1 ACHE CBS MAPT
43 internuclear ophthalmoplegia 10.0 KANTR MBP PSEN1
44 colonic pseudo-obstruction 10.0 ACHE BCHE KANTR
45 auditory agnosia 10.0 KANTR PRNP
46 frontotemporal dementia and/or amyotrophic lateral sclerosis 1 10.0 CBS GRN MAPT PSEN1 TARDBP
47 transient global amnesia 10.0 KANTR PRNP PSEN1
48 vascular dementia 10.0 ACHE BCHE MAPT MBP PSEN1
49 peripheral nervous system disease 10.0 ACHE KANTR MBP
50 oculomotor nerve paralysis 10.0 KANTR MBP PNMA2

Graphical network of the top 20 diseases related to Agraphia:



Diseases related to Agraphia

Symptoms & Phenotypes for Agraphia

UMLS symptoms related to Agraphia:


other symbolic dysfunction

GenomeRNAi Phenotypes related to Agraphia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with paclitaxel GR00293-A 8.92 DEDD PPP3CA PRTN3 TP53

MGI Mouse Phenotypes related to Agraphia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.21 ACHE DEDD GRN MAPK14 MAPT MBP
2 growth/size/body region MP:0005378 10.2 ACHE DEDD GRN MAPK14 MAPT MBP
3 cellular MP:0005384 10.18 GRN MAPK14 MAPT MBP POU3F3 PRNP
4 homeostasis/metabolism MP:0005376 10.18 ACHE BCHE GRN MAPK14 MAPT MBP
5 immune system MP:0005387 10.11 DEDD GRN MAPK14 MAPT MBP PPP3CA
6 mortality/aging MP:0010768 10.1 ACHE BCHE GRN MAPK14 MAPT MBP
7 nervous system MP:0003631 9.93 ACHE DEDD GRN MAPK14 MAPT MBP
8 muscle MP:0005369 9.86 ACHE MAPK14 MAPT PPP3CA PRNP PSEN1
9 no phenotypic analysis MP:0003012 9.5 ACHE GRN MAPT PRNP PRTN3 TARDBP
10 reproductive system MP:0005389 9.28 ACHE BCHE DEDD GRN MAPK14 MBP

Drugs & Therapeutics for Agraphia

Drugs for Agraphia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 tannic acid Approved Not Applicable
2
Benzocaine Approved, Investigational Not Applicable 94-09-7, 1994-09-7 2337

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Handwriting Intervention, SML vs. Conventional Occupational Therapy (OT), in a Junior High School Completed NCT03514992 Not Applicable
2 Effectiveness of a Handwriting Intervention Completed NCT02620098 Not Applicable
3 Graphomotor Intervention Program for Handwriting Difficulties Prevention in School-Age Recruiting NCT03699800 Not Applicable
4 Graphomotor Intervention Program for Handwriting Difficulties Prevention in Preschool Age Recruiting NCT03699787 Not Applicable
5 Neurobiology of Language Recovery in Aphasia: Natural History and Treatment-Induced Recovery Active, not recruiting NCT01927302 Not Applicable
6 Treatment for Reading and Writing Deficits Following Acquired Brain Injury Enrolling by invitation NCT03662243

Search NIH Clinical Center for Agraphia

Genetic Tests for Agraphia

Anatomical Context for Agraphia

MalaCards organs/tissues related to Agraphia:

41
Brain, Temporal Lobe, Occipital Lobe, Testes, B Cells, Parietal Lobe, Colon

Publications for Agraphia

Articles related to Agraphia:

(show top 50) (show all 260)
# Title Authors Year
1
The neural substrates of improved phonological processing following successful treatment in a case of phonological alexia and agraphia. ( 29350575 )
2018
2
Revival of Historical Kana Orthography in a Patient with Allographic Agraphia. ( 29491278 )
2018
3
Molecular neuroimaging in primary progressive aphasia with predominant agraphia. ( 29569990 )
2018
4
Unilateral Apraxic Agraphia without Ideomotor Apraxia from a callosal lesion in a patient with Marchiafava-Bignami disease. ( 29482459 )
2018
5
Agraphia of the left hand with dysfunction of the left superior parietal region without callosal lesions. ( 29430524 )
2018
6
Agraphia with reversible splenial corpus callosum lesion caused by hypoglycemia. ( 29606344 )
2018
7
Frontal Phonological Agraphia and Acalculia with Impaired Verbal Short-Term Memory due to Left Inferior Precentral Gyrus Lesion. ( 29681826 )
2018
8
Maximising recovery from aphasia with central and peripheral agraphia: The benefit of sequential treatments. ( 29298550 )
2018
9
Hypothalamic relapse of a cardiac large B-cell lymphoma presenting with memory loss, confabulation, alexia-agraphia, apathy, hypersomnia, appetite disturbances and diabetes insipidus. ( 30150329 )
2018
10
A Case of Nonalcoholic Marchiafava-Bignami Disease with Left-Right Differential Agraphia of Chinese Characters. ( 30283321 )
2018
11
Multi-step treatment for acquired alexia and agraphia (Part I): efficacy, generalisation, and identification of beneficial treatment steps. ( 28421858 )
2017
12
Agraphia manifesting during a WhatsApp conversation. ( 29169804 )
2017
13
A Case of Anoxic Brain Injury Presenting with Agraphia of kanji in the Foreground. ( 28611641 )
2017
14
Alexia Without Agraphia: A Rare Entity. ( 28690938 )
2017
15
Multi-step treatment for acquired alexia and agraphia (part II): a dual-route error scoring system. ( 28421910 )
2017
16
Characteristics of Agraphia in Chinese Patients with Alzheimer's Disease and Amnestic Mild Cognitive Impairment. ( 27364791 )
2016
17
Agraphia in Amyotrophic Lateral Sclerosis with Frontotemporal Lobe Degeneration. ( 26905000 )
2016
18
The nature and treatment of phonological text agraphia. ( 27392251 )
2016
19
The Ege Agraphia Test Battery for Identifying the Writing Disorders in Cases with Mild Cognitive Impairment and Alzheimer's Disease. ( 27711939 )
2016
20
Brain pathology case of the month August 2016 - case 2 A 71 year old man presenting with headache, blurry vision and alexia without agraphia. ( 27647576 )
2016
21
Pure agraphia after infarction in the superior and middle portions of the left precentral gyrus: Dissociation between Kanji and Kana. ( 26597609 )
2016
22
Apraxic agraphia following thalamic damage: Three new cases. ( 26460984 )
2015
23
What letters can "learn" from Arabic digits - fMRI-controlled single case therapy study of peripheral agraphia. ( 26186229 )
2015
24
Reversible cursive agraphia. ( 26195237 )
2015
25
Apraxic agraphia following bithalamic damage. ( 25682350 )
2015
26
Agraphia caused by acute right parietal infarction. ( 25564267 )
2015
27
Agraphia in Mobile Text Messages in a Case of Amyotrophic Lateral Sclerosis with Frontotemporal Dementia. ( 26631894 )
2015
28
Treatment for Alexia With Agraphia Following Left Ventral Occipito-Temporal Damage: Strengthening Orthographic Representations Common to Reading and Spelling. ( 26110814 )
2015
29
Alexia Without Agraphia in a Right-Handed Individual Following Right Occipital Stroke. ( 26397830 )
2015
30
A Case of Apraxic Agraphia in a Patient With Progressive Supranuclear Palsy. ( 30363585 )
2015
31
Agraphia in patients with frontotemporal dementia and parkinsonism linked to chromosome 17 with P301L MAPT mutation: dysexecutive, aphasic, apraxic or spatial phenomenon? ( 23121543 )
2014
32
Agraphia caused by an infarction in Exner's area. ( 23916761 )
2014
33
Right Brain: A reading specialist with alexia without agraphia: Teacher interrupted. ( 24379102 )
2014
34
Agraphia of Kanji (Chinese characters): an early symptom of sporadic Creutzfeldt-Jakob disease in a Japanese patient: a case report. ( 25098795 )
2014
35
Progressive Wallerian Degeneration of the Corpus Callosal Splenium in a Patient with Alexia Without Agraphia: Advanced MR Findings. ( 25489886 )
2014
36
Posterior cerebral artery stroke presenting as alexia without agraphia. ( 24935413 )
2014
37
Clinical presentation of left angular gyrus ischaemic lesion: finger agnosia, acalculia, agraphia, left-right disorientation and episodic autoscopia. ( 23813508 )
2013
38
Pure agraphia in Romaji after left inferior frontal gyrus infarction: A case of selective deficit in syllable-to-grapheme conversion in Japanese. ( 23954318 )
2013
39
Progressive apraxic agraphia with micrographia presenting as corticobasal syndrome showing extensive Pittsburgh compound B uptake. ( 23589191 )
2013
40
Agraphia caused by left thalamic hemorrhage. ( 23620716 )
2013
41
Transient beneficial effects of excitatory theta burst stimulation in a patient with phonological agraphia after left supramarginal gyrus infarction. ( 22296779 )
2012
42
Allographic agraphia for single letters. ( 22713390 )
2012
43
Thalamic alexia with agraphia. ( 22593808 )
2012
44
Functional dissociation between Kana and Kanji: agraphia following a thalamic hemorrhage. ( 21894554 )
2012
45
Compensational strategies for a merchant after stroke with anosognosia for alexia without agraphia. ( 20829414 )
2011
46
Temporal lobe epilepsy manifesting as alexia with agraphia for kanji. ( 21907629 )
2011
47
Posterior cortical atrophy with prominent alexia without agraphia in a Tourette syndrome. ( 21912890 )
2011
48
The specificity of notation codes in apraxic agraphia: dissociation between Arabic and alphabetical scripts in a patient with severe ideomotor and visuoconstructional apraxia. ( 20672223 )
2011
49
Isolated thalamic agraphia with impaired grapheme formation and micrographia. ( 21380791 )
2011
50
Sporadic corticobasal syndrome with progranulin mutation presenting as progressive apraxic agraphia. ( 21403024 )
2011

Variations for Agraphia

Expression for Agraphia

Search GEO for disease gene expression data for Agraphia.

Pathways for Agraphia

Pathways related to Agraphia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.58 MBP PPP3CA TP53
2 11.56 MAPT MBP PRNP PSEN1 TARDBP
3
Show member pathways
11.49 MAPK14 PPP3CA TP53
4 11.07 MAPK14 PPP3CA PSEN1
5 10.86 MAPT PRNP TP53

GO Terms for Agraphia

Cellular components related to Agraphia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.97 ACHE CBS DEDD MAPK14 MAPT MBP
2 cell surface GO:0009986 9.35 ACHE MBP PRNP PSEN1 PVR
3 membrane raft GO:0045121 8.92 MAPT PRNP PRTN3 PSEN1

Biological processes related to Agraphia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 3'-UTR-mediated mRNA stabilization GO:0070935 9.4 MAPK14 TARDBP
2 amyloid precursor protein metabolic process GO:0042982 9.37 ACHE PSEN1
3 negative regulation of protein phosphorylation GO:0001933 9.33 PRNP PSEN1 TARDBP
4 astrocyte activation GO:0048143 9.32 MAPT PSEN1
5 neuron projection maintenance GO:1990535 9.26 PRNP PSEN1
6 cellular response to drug GO:0035690 9.13 PPP3CA PRNP TP53
7 modulation of age-related behavioral decline GO:0090647 8.62 PRNP PSEN1

Molecular functions related to Agraphia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.91 BCHE CBS MAPT PRNP TARDBP TP53
2 chaperone binding GO:0051087 9.58 MAPT PRNP TP53
3 protease binding GO:0002020 9.54 MBP PRNP TP53
4 amyloid-beta binding GO:0001540 9.43 ACHE BCHE PRNP
5 enzyme binding GO:0019899 9.17 BCHE CBS MAPK14 MAPT PPP3CA PRTN3
6 cholinesterase activity GO:0004104 9.16 ACHE BCHE
7 acetylcholinesterase activity GO:0003990 8.96 ACHE BCHE
8 protein binding GO:0005515 10.22 ACHE CBS CDR1 DEDD GRN MAPK14

Sources for Agraphia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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