Aliases & Classifications for Agraphia

Summaries for Agraphia

Disease Ontology : 12 An acquired writing disorder causing a loss in the ability to communicate through writing, either due to some motor dysfunction or the inability to spell.

MalaCards based summary : Agraphia is related to progressive non-fluent aphasia and alexia, and has symptoms including other symbolic dysfunction An important gene associated with Agraphia is MAPT (Microtubule Associated Protein Tau), and among its related pathways/superpathways are Synthesis of PC and Neurotransmitter Clearance In The Synaptic Cleft. The drugs Benzocaine and tannic acid have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and occipital lobe, and related phenotypes are hematopoietic system and growth/size/body region

Wikipedia : 77 Agraphia is an acquired neurological disorder causing a loss in the ability to communicate through... more...

Related Diseases for Agraphia

Diseases related to Agraphia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Related Disease Score Top Affiliating Genes
1 progressive non-fluent aphasia 32.0 C9orf72 GRN MAPT
2 alexia 31.4 KANTR MBP PPP3CA
3 apraxia 30.7 C9orf72 GRN MAPT
4 aphasia 30.6 C9orf72 GRN MAPT PRNP
5 frontotemporal lobar degeneration with tdp43 inclusions, grn-related 30.5 GRN MAPT
6 nominal aphasia 30.5 GRN MAPT
7 alzheimer disease 30.2 ACHE BCHE GRN MAPT PRNP
8 ideomotor apraxia 30.1 GRN MAPT MBP
9 supranuclear palsy, progressive, 1 30.1 ACHE GRN MAPT
10 semantic dementia 30.1 C9orf72 GRN MAPT
11 dementia 30.0 ACHE BCHE C9orf72 GRN MAPT PRNP
12 frontotemporal dementia 29.8 ACHE C9orf72 GRN MAPT PRNP
13 amyotrophic lateral sclerosis 1 29.8 C9orf72 CDR1 GRN MAPT PRNP
14 dysgraphia 11.7
15 gerstmann syndrome 11.3
16 inclusion body myopathy with early-onset paget disease and frontotemporal dementia 11.1
17 echolalia 10.3 GRN MAPT
18 butyrylcholinesterase deficiency 10.3 ACHE BCHE
19 akinetic mutism 10.3 MAPT PRNP
20 panencephalitis, subacute sclerosing 10.3 MAPT MBP
21 behavioral variant of frontotemporal dementia 10.2 C9orf72 GRN MAPT
22 binswanger's disease 10.2 ACHE MAPT
23 frontotemporal dementia and/or amyotrophic lateral sclerosis 1 10.2 C9orf72 GRN MAPT
24 postencephalitic parkinson disease 10.2 KANTR MAPT
25 disease of mental health 10.2 C9orf72 GRN MAPT
26 posterior myocardial infarction 10.2 KANTR MAPT
27 multiple sclerosis 10.1
28 lateral sclerosis 10.1
29 marchiafava bignami disease 10.1
30 auditory agnosia 10.1 KANTR PRNP
31 motor neuron disease 10.1 C9orf72 GRN MAPT
32 central nervous system disease 10.1 MAPT MBP PRNP
33 tabes dorsalis 10.1 KANTR MBP
34 vascular dementia 10.1 ACHE BCHE MAPT MBP
35 visual agnosia 10.1 GRN KANTR
36 peripheral nervous system disease 10.1 ACHE KANTR MBP
37 colonic pseudo-obstruction 10.0 ACHE BCHE KANTR
38 anterior spinal artery syndrome 10.0 KANTR MBP
39 functional colonic disease 10.0 BCHE KANTR
40 oculomotor nerve paralysis 10.0 KANTR MBP PNMA2
41 third cranial nerve disease 10.0 KANTR MBP PNMA2
42 creutzfeldt-jakob disease 10.0
43 thrombosis 10.0
44 agnosia 10.0
45 movement disease 10.0
46 acute disseminated encephalomyelitis 10.0
47 encephalitis 10.0
48 posterior cortical atrophy 10.0
49 speech and communication disorders 9.9 C9orf72 GRN KANTR MAPT
50 dementia, lewy body 9.9 ACHE BCHE GRN MAPT PRNP

Graphical network of the top 20 diseases related to Agraphia:



Diseases related to Agraphia

Symptoms & Phenotypes for Agraphia

UMLS symptoms related to Agraphia:


other symbolic dysfunction

MGI Mouse Phenotypes related to Agraphia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.11 ACHE C9orf72 CBSL DEDD GRN MAPK14
2 growth/size/body region MP:0005378 10.1 ACHE C9orf72 CBSL DEDD GRN MAPK14
3 immune system MP:0005387 10.02 C9orf72 CBSL DEDD GRN MAPK14 MAPT
4 mortality/aging MP:0010768 10 ACHE BCHE C9orf72 CBSL GRN MAPK14
5 nervous system MP:0003631 9.9 ACHE C9orf72 CBSL DEDD GRN MAPK14
6 no phenotypic analysis MP:0003012 9.43 ACHE C9orf72 GRN MAPT PRNP PRTN3
7 reproductive system MP:0005389 9.23 ACHE BCHE CBSL DEDD GRN MAPK14

Drugs & Therapeutics for Agraphia

Drugs for Agraphia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzocaine Approved, Investigational Not Applicable 94-09-7, 1994-09-7 2337
2
tannic acid Approved Not Applicable 1401-55-4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment for Reading and Writing Deficits Following Acquired Brain Injury Enrolling by invitation NCT03662243
2 Graphomotor Intervention Program for Handwriting Difficulties Prevention in School-Age Recruiting NCT03699800 Not Applicable
3 Graphomotor Intervention Program for Handwriting Difficulties Prevention in Preschool Age Recruiting NCT03699787 Not Applicable
4 Handwriting Intervention, SML vs. Conventional Occupational Therapy (OT), in a Junior High School Completed NCT03514992 Not Applicable
5 Effectiveness of a Handwriting Intervention Completed NCT02620098 Not Applicable
6 Neurobiology of Language Recovery in Aphasia: Natural History and Treatment-Induced Recovery Active, not recruiting NCT01927302 Not Applicable

Search NIH Clinical Center for Agraphia

Genetic Tests for Agraphia

Anatomical Context for Agraphia

MalaCards organs/tissues related to Agraphia:

42
Brain, Temporal Lobe, Occipital Lobe, Testes, B Cells, Parietal Lobe

Publications for Agraphia

Articles related to Agraphia:

(show top 50) (show all 261)
# Title Authors Year
1
The neural substrates of improved phonological processing following successful treatment in a case of phonological alexia and agraphia. ( 29350575 )
2018
2
Revival of Historical Kana Orthography in a Patient with Allographic Agraphia. ( 29491278 )
2018
3
Molecular neuroimaging in primary progressive aphasia with predominant agraphia. ( 29569990 )
2018
4
Unilateral Apraxic Agraphia without Ideomotor Apraxia from a callosal lesion in a patient with Marchiafava-Bignami disease. ( 29482459 )
2018
5
Agraphia of the left hand with dysfunction of the left superior parietal region without callosal lesions. ( 29430524 )
2018
6
Agraphia with reversible splenial corpus callosum lesion caused by hypoglycemia. ( 29606344 )
2018
7
Frontal Phonological Agraphia and Acalculia with Impaired Verbal Short-Term Memory due to Left Inferior Precentral Gyrus Lesion. ( 29681826 )
2018
8
Maximising recovery from aphasia with central and peripheral agraphia: The benefit of sequential treatments. ( 29298550 )
2018
9
Hypothalamic relapse of a cardiac large B-cell lymphoma presenting with memory loss, confabulation, alexia-agraphia, apathy, hypersomnia, appetite disturbances and diabetes insipidus. ( 30150329 )
2018
10
A Case of Nonalcoholic Marchiafava-Bignami Disease with Left-Right Differential Agraphia of Chinese Characters. ( 30283321 )
2018
11
Cardiac Sarcoidosis as an Uncommon Etiology for Posterior Circulation Stroke Presenting with Alexia without Agraphia. ( 30652036 )
2018
12
Multi-step treatment for acquired alexia and agraphia (Part I): efficacy, generalisation, and identification of beneficial treatment steps. ( 28421858 )
2017
13
Agraphia manifesting during a WhatsApp conversation. ( 29169804 )
2017
14
A Case of Anoxic Brain Injury Presenting with Agraphia of kanji in the Foreground. ( 28611641 )
2017
15
Alexia Without Agraphia: A Rare Entity. ( 28690938 )
2017
16
Multi-step treatment for acquired alexia and agraphia (part II): a dual-route error scoring system. ( 28421910 )
2017
17
Characteristics of Agraphia in Chinese Patients with Alzheimer's Disease and Amnestic Mild Cognitive Impairment. ( 27364791 )
2016
18
Agraphia in Amyotrophic Lateral Sclerosis with Frontotemporal Lobe Degeneration. ( 26905000 )
2016
19
The nature and treatment of phonological text agraphia. ( 27392251 )
2016
20
The Ege Agraphia Test Battery for Identifying the Writing Disorders in Cases with Mild Cognitive Impairment and Alzheimer's Disease. ( 27711939 )
2016
21
Brain pathology case of the month August 2016 - case 2 A 71 year old man presenting with headache, blurry vision and alexia without agraphia. ( 27647576 )
2016
22
Pure agraphia after infarction in the superior and middle portions of the left precentral gyrus: Dissociation between Kanji and Kana. ( 26597609 )
2016
23
Apraxic agraphia following thalamic damage: Three new cases. ( 26460984 )
2015
24
What letters can "learn" from Arabic digits - fMRI-controlled single case therapy study of peripheral agraphia. ( 26186229 )
2015
25
Reversible cursive agraphia. ( 26195237 )
2015
26
Apraxic agraphia following bithalamic damage. ( 25682350 )
2015
27
Agraphia caused by acute right parietal infarction. ( 25564267 )
2015
28
Agraphia in Mobile Text Messages in a Case of Amyotrophic Lateral Sclerosis with Frontotemporal Dementia. ( 26631894 )
2015
29
Treatment for Alexia With Agraphia Following Left Ventral Occipito-Temporal Damage: Strengthening Orthographic Representations Common to Reading and Spelling. ( 26110814 )
2015
30
Alexia Without Agraphia in a Right-Handed Individual Following Right Occipital Stroke. ( 26397830 )
2015
31
A Case of Apraxic Agraphia in a Patient With Progressive Supranuclear Palsy. ( 30363585 )
2015
32
Agraphia in patients with frontotemporal dementia and parkinsonism linked to chromosome 17 with P301L MAPT mutation: dysexecutive, aphasic, apraxic or spatial phenomenon? ( 23121543 )
2014
33
Agraphia caused by an infarction in Exner's area. ( 23916761 )
2014
34
Right Brain: A reading specialist with alexia without agraphia: Teacher interrupted. ( 24379102 )
2014
35
Agraphia of Kanji (Chinese characters): an early symptom of sporadic Creutzfeldt-Jakob disease in a Japanese patient: a case report. ( 25098795 )
2014
36
Progressive Wallerian Degeneration of the Corpus Callosal Splenium in a Patient with Alexia Without Agraphia: Advanced MR Findings. ( 25489886 )
2014
37
Posterior cerebral artery stroke presenting as alexia without agraphia. ( 24935413 )
2014
38
Clinical presentation of left angular gyrus ischaemic lesion: finger agnosia, acalculia, agraphia, left-right disorientation and episodic autoscopia. ( 23813508 )
2013
39
Pure agraphia in Romaji after left inferior frontal gyrus infarction: A case of selective deficit in syllable-to-grapheme conversion in Japanese. ( 23954318 )
2013
40
Progressive apraxic agraphia with micrographia presenting as corticobasal syndrome showing extensive Pittsburgh compound B uptake. ( 23589191 )
2013
41
Agraphia caused by left thalamic hemorrhage. ( 23620716 )
2013
42
Transient beneficial effects of excitatory theta burst stimulation in a patient with phonological agraphia after left supramarginal gyrus infarction. ( 22296779 )
2012
43
Allographic agraphia for single letters. ( 22713390 )
2012
44
Thalamic alexia with agraphia. ( 22593808 )
2012
45
Functional dissociation between Kana and Kanji: agraphia following a thalamic hemorrhage. ( 21894554 )
2012
46
Compensational strategies for a merchant after stroke with anosognosia for alexia without agraphia. ( 20829414 )
2011
47
Temporal lobe epilepsy manifesting as alexia with agraphia for kanji. ( 21907629 )
2011
48
Posterior cortical atrophy with prominent alexia without agraphia in a Tourette syndrome. ( 21912890 )
2011
49
The specificity of notation codes in apraxic agraphia: dissociation between Arabic and alphabetical scripts in a patient with severe ideomotor and visuoconstructional apraxia. ( 20672223 )
2011
50
Alexia without agraphia. ( 21675099 )
2011

Variations for Agraphia

Expression for Agraphia

Search GEO for disease gene expression data for Agraphia.

Pathways for Agraphia

GO Terms for Agraphia

Cellular components related to Agraphia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 ACHE BCHE C9orf72 GRN MAPK14 MAPT
2 main axon GO:0044304 8.62 C9orf72 MAPT

Biological processes related to Agraphia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 stress granule assembly GO:0034063 8.62 C9orf72 MAPT

Molecular functions related to Agraphia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.55 BCHE MAPK14 MAPT PPP3CA PRTN3
2 amyloid-beta binding GO:0001540 9.43 ACHE BCHE PRNP
3 cholinesterase activity GO:0004104 8.96 ACHE BCHE
4 acetylcholinesterase activity GO:0003990 8.62 ACHE BCHE

Sources for Agraphia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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