Aliases & Classifications for Agraphia

Summaries for Agraphia

Disease Ontology : 12 An acquired writing disorder causing a loss in the ability to communicate through writing, either due to some motor dysfunction or the inability to spell.

MalaCards based summary : Agraphia is related to gerstmann syndrome and dysgraphia, and has symptoms including other symbolic dysfunction An important gene associated with Agraphia is MAPT (Microtubule Associated Protein Tau). The drugs tannic acid and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and cortex, and related phenotypes are growth/size/body region and hematopoietic system

Wikipedia : 74 Agraphia is an acquired neurological disorder causing a loss in the ability to communicate through... more...

Related Diseases for Agraphia

Diseases related to Agraphia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 164)
# Related Disease Score Top Affiliating Genes
1 gerstmann syndrome 33.2 MAPT CBSL
2 dysgraphia 32.3 TARDBP MAPT GRN CBSL C9orf72
3 apraxia 31.3 MAPT GRN C9orf72
4 inclusion body myopathy with paget disease of bone and frontotemporal dementia 31.2 VCP TARDBP C9orf72
5 progressive non-fluent aphasia 31.1 VCP MAPT GRN C9orf72
6 corticobasal degeneration 30.7 TARDBP MAPT
7 anosognosia 30.7 CBSL C9orf72
8 alexia 30.6 PRSS3 MTSS2 MAPT GRN CBSL
9 frontotemporal lobar degeneration with tdp43 inclusions, grn-related 30.6 MAPT GRN
10 amnestic disorder 30.1 MAPT ACHE
11 anterograde amnesia 30.0 PNMA2 ACHE
12 ideomotor apraxia 30.0 TARDBP MIR4277 MAPT GRN CBSL
13 reading disorder 30.0 PRSS3 IQCB1
14 prosopagnosia 29.9 TARDBP PRSS3 MAPT GRN
15 visual agnosia 29.9 MTSS2 MAPT GRN CBSL
16 lateral sclerosis 29.9 VCP TARDBP C9orf72
17 simultanagnosia 29.8 MTSS2 MAPT CBSL ACHE
18 finger agnosia 29.7 MTSS2 MIR4277 MAPT CBSL
19 prion disease 29.7 TARDBP PRNP MAPT
20 mutism 29.6 PRNP MAPT GRN C9orf72
21 semantic dementia 29.5 TARDBP MAPT GRN C9orf72
22 movement disease 29.4 TARDBP MAPT GRN CBSL C9orf72
23 alzheimer disease 28.7 VCP TARDBP PRNP MAPT GRN ACHE
24 aphasia 28.6 VCP TARDBP PRSS3 PRNP MAPT GRN
25 motor neuron disease 28.6 VCP TARDBP MAPT GRN C9orf72
26 dementia 28.3 VCP TARDBP PRNP MAPT GRN C9orf72
27 amyotrophic lateral sclerosis 1 28.2 VCP TARDBP PRSS3 PRNP MAPT GRN
28 frontotemporal dementia 28.2 VCP TARDBP PRNP MAPT GRN C9orf72
29 nominal aphasia 27.7 VCP TARDBP PRSS3 MTSS2 MAPT GRN
30 supranuclear palsy, progressive, 1 27.4 VCP TARDBP PRNP MAPT GRN CBSL
31 pick disease of brain 27.4 VCP TARDBP PRNP MAPT GRN CBSL
32 writing disorder 27.4 VCP TARDBP PRSS3 PRNP MAPT IQCB1
33 speech and communication disorders 27.4 VCP TARDBP PRSS3 MAPT IQCB1 GRN
34 agnosia 10.5
35 dyslexia 10.4
36 yemenite deaf-blind hypopigmentation syndrome 10.4
37 alzheimer disease 10 10.3 MAPT ACHE
38 binswanger's disease 10.3 MAPT ACHE
39 hemiplegia 10.3
40 hand skill, relative 10.3
41 postencephalitic parkinson disease 10.3 TARDBP MAPT
42 ataxia and polyneuropathy, adult-onset 10.2
43 amusia 10.2
44 glioma 10.2
45 glial tumor 10.2
46 echolalia 10.2 MAPT GRN
47 arteriolosclerosis 10.2 TARDBP MAPT
48 rem sleep behavior disorder 10.2 MAPT ACHE
49 amyotrophic lateral sclerosis type 22 10.2 TARDBP C9orf72
50 multiple sclerosis 10.2

Graphical network of the top 20 diseases related to Agraphia:



Diseases related to Agraphia

Symptoms & Phenotypes for Agraphia

UMLS symptoms related to Agraphia:


other symbolic dysfunction

MGI Mouse Phenotypes related to Agraphia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.97 ACHE C9orf72 CBSL GRN IQCB1 MAPT
2 hematopoietic system MP:0005397 9.91 ACHE C9orf72 CBSL GRN MAPT PRNP
3 muscle MP:0005369 9.63 ACHE CBSL MAPT PRNP TARDBP VCP
4 nervous system MP:0003631 9.56 ACHE C9orf72 CBSL GRN MAPT PRNP
5 no phenotypic analysis MP:0003012 9.1 ACHE C9orf72 GRN MAPT PRNP TARDBP

Drugs & Therapeutics for Agraphia

Drugs for Agraphia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
tannic acid Approved 1401-55-4
2
Benzocaine Approved, Investigational 94-09-7, 1994-09-7 2337

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Handwriting Intervention, With vs. Without a Rightward Bias, in a Junior High School-A Randomized Controlled Study Completed NCT03903614
2 The Center for the Neurobiology of Language Recovery (CNLR) Completed NCT01927302
3 Effectiveness of a Handwriting Intervention With At-Risk Kindergarteners Completed NCT02620098
4 The Effects of a Graphomotor Intervention Program According to a Psychomotor Approach on Quality and Speed of Handwriting in School-Age Children: A Randomized Controlled Trial Completed NCT03699800
5 The Effects of a Graphomotor Intervention Program According to a Psychomotor Approach on Graphomotor Competences in Preschool Children: A Randomized Controlled Trial Completed NCT03699787
6 Improving Electronic Written Communication in Persons With Aphasia: A Clinical Trial Recruiting NCT03773419
7 Treatment for Reading and Writing Deficits Following Acquired Brain Injury Enrolling by invitation NCT03662243

Search NIH Clinical Center for Agraphia

Genetic Tests for Agraphia

Anatomical Context for Agraphia

MalaCards organs/tissues related to Agraphia:

40
Brain, Temporal Lobe, Cortex, Parietal Lobe, Occipital Lobe, Testes, Bone

Publications for Agraphia

Articles related to Agraphia:

(show top 50) (show all 720)
# Title Authors PMID Year
1
Proactive interference apraxic agraphia: a writing and drawing disorder associated with corticobasal syndrome. 61
32323627 2020
2
Seeing is not believing. 61
30953621 2020
3
A case of myelin oligodendrocyte glycoprotein-antibody-associated disease presenting with tumefactive demyelinating lesion. 61
32474283 2020
4
Alexia Without Agraphia as the Initial Manifestation of Progressive Multifocal Leukoencephalopathy in Chronic Lymphocytic Leukemia. 61
31839871 2020
5
Ictal multicomponent agraphia in left temporal lobe epilepsy. 61
31889011 2020
6
Agraphia manifesting during a WhatsApp conversation. 61
29169804 2020
7
A case of aneurysmal subarchnoid haemorrhage and superficial siderosis complicated by prospagnosia, simultagnosia and alexia without agraphia. 61
31790281 2019
8
[Progressive supranuclear palsy-Richardson syndrome with visual attention disturbance (Holmes and Horrax) and ataxie optique (Garcin): a case report]. 61
31656263 2019
9
Maximising recovery from aphasia with central and peripheral agraphia: The benefit of sequential treatments. 61
29298550 2019
10
[A Skilled Typist with Typing Disorder Following Resection of a Left Frontal Lobe Tumor]. 61
31588054 2019
11
History of cerebral localization and the emigration plight of three neuroscience giants from Nazi Germany: Josef Gerstmann, Adolf Wallenberg, and Franz Josef Kallmann. 61
31473673 2019
12
The making of a syndrome: The English translation of Gerstmann's first report. 61
31029874 2019
13
Alexia and Agraphia Intervention Following Traumatic Brain Injury: A Single Case Study. 61
31194917 2019
14
Alexia without Agraphia-report of Five Cases and Review of Literature. 61
31559778 2019
15
Multi-step treatment for acquired alexia and agraphia (Part I): efficacy, generalisation, and identification of beneficial treatment steps. 61
28421858 2019
16
Multi-step treatment for acquired alexia and agraphia (part II): a dual-route error scoring system. 61
28421910 2019
17
Gray Matter Correlates of Finger Gnosis in Children: A VBM Study. 61
30699334 2019
18
Maurice Ravel's dementia: the silence of a genius. 61
30810599 2019
19
Cognitive Rehabilitation of Acquired Calculation Disturbances. 61
31093301 2019
20
Kanji (Morphogram) and Kana (Phonogram) Problem in Japanese Alexia and Agraphia. 61
31220841 2019
21
Alexia and Agraphia from 1861 to 1965. 61
31220840 2019
22
Two year outcomes of poststroke writing and reading disorders. 61
28489413 2018
23
Agraphia with reversible splenial corpus callosum lesion caused by hypoglycemia. 61
29606344 2018
24
Hypothalamic relapse of a cardiac large B-cell lymphoma presenting with memory loss, confabulation, alexia-agraphia, apathy, hypersomnia, appetite disturbances and diabetes insipidus. 61
30150329 2018
25
The nature and treatment of phonological text agraphia. 61
27392251 2018
26
Neuroradiologic correlation with aphasias. Cortico-subcortical map of language. 61
29439808 2018
27
A Case of Nonalcoholic Marchiafava-Bignami Disease with Left-Right Differential Agraphia of Chinese Characters. 61
30283321 2018
28
Molecular neuroimaging in primary progressive aphasia with predominant agraphia. 61
29569990 2018
29
Medial-Vowel Writing Difficulty in Korean Syllabic Writing: A Characteristic Sign of Alzheimer's Disease. 61
29504296 2018
30
Agraphia of the left hand with dysfunction of the left superior parietal region without callosal lesions. 61
29430524 2018
31
Unilateral Apraxic Agraphia without Ideomotor Apraxia from a callosal lesion in a patient with Marchiafava-Bignami disease. 61
29482459 2018
32
The neural substrates of improved phonological processing following successful treatment in a case of phonological alexia and agraphia. 61
29350575 2018
33
Phenotypic variability and neuropsychological findings associated with C9orf72 repeat expansions in a Bulgarian dementia cohort. 61
30550541 2018
34
Cardiac Sarcoidosis as an Uncommon Etiology for Posterior Circulation Stroke Presenting with Alexia without Agraphia. 61
30652036 2018
35
Gerstmann syndrome: historic and current perspectives. 61
29519471 2018
36
The history of the neurophysiology and neurology of the parietal lobe. 61
29519464 2018
37
Revival of Historical Kana Orthography in a Patient with Allographic Agraphia. 61
29491278 2018
38
Frontal Phonological Agraphia and Acalculia with Impaired Verbal Short-Term Memory due to Left Inferior Precentral Gyrus Lesion. 61
29681826 2018
39
[A Case of Kanji Agraphia Resulting from Intracerebral Hemorrhage on the Left Temporal Lobe Associated with Multiple Dural Arteriovenous Fistulas]. 61
29282347 2017
40
Widespread enlarged perivascular spaces associated with dementia and focal brain dysfunction: case report. 61
29212461 2017
41
Gerstmann's syndrome and unilateral optic ataxia in the emergency department. 61
29354229 2017
42
Historical Perspectives on Ancient Greek Derived "a" Prefixed Nomenclature for Acquired Neurocognitive Impairment. 61
28484905 2017
43
Squaring the round: An unusual progressive graphomotor impairment with post-mortem findings. 61
26362247 2017
44
Callosal Motor Impersistence: A Novel Disconnection Syndrome. 61
28632524 2017
45
[Efficacy and safety of cyclophosphamide as a sequential immunotherapy drug for anti-N-methyl-D-aspartate receptor encephalitis in children]. 61
28606234 2017
46
Alexia Without Agraphia: A Rare Entity. 61
28690938 2017
47
[Brodmann Areas 39 and 40: Human Parietal Association Area and Higher Cortical Function]. 61
28424400 2017
48
Transient Gerstmann syndrome as manifestation of stroke: Case report and brief literature review. 61
29213512 2017
49
Yellow fever vaccine-associated neurological disease, a suspicious case. 61
28254833 2017
50
Historical evidence supports El Greco's depiction of a neurological condition in his attributed self-portrait. 61
28017236 2017

Variations for Agraphia

Expression for Agraphia

Search GEO for disease gene expression data for Agraphia.

Pathways for Agraphia

GO Terms for Agraphia

Cellular components related to Agraphia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 main axon GO:0044304 8.96 MAPT C9orf72
2 cytoplasmic stress granule GO:0010494 8.8 VCP TARDBP C9orf72

Biological processes related to Agraphia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of neuron death GO:1901216 9.16 PRNP MAPT
2 stress granule assembly GO:0034063 8.96 MAPT C9orf72
3 negative regulation of protein phosphorylation GO:0001933 8.8 TARDBP PRNP C9orf72

Molecular functions related to Agraphia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chaperone binding GO:0051087 8.8 PRNP MAPT GRN

Sources for Agraphia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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