Aliases & Classifications for Agraphia

Summaries for Agraphia

Disease Ontology : 12 An acquired writing disorder causing a loss in the ability to communicate through writing, either due to some motor dysfunction or the inability to spell.

MalaCards based summary : Agraphia is related to progressive non-fluent aphasia and alexia, and has symptoms including other symbolic dysfunction An important gene associated with Agraphia is MAPT (Microtubule Associated Protein Tau), and among its related pathways/superpathways are Brain-Derived Neurotrophic Factor (BDNF) signaling pathway and Synthesis of PC. The drugs tannic acid and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include brain, parietal lobe and cortex, and related phenotypes are growth/size/body region and cellular

Wikipedia : 75 Agraphia is an acquired neurological disorder causing a loss in the ability to communicate through... more...

Related Diseases for Agraphia

Diseases related to Agraphia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 135)
# Related Disease Score Top Affiliating Genes
1 progressive non-fluent aphasia 32.4 MAPT GRN C9orf72
2 alexia 32.2 PPP3CA MBP
3 apraxia 31.6 MAPT GRN C9orf72
4 nominal aphasia 31.6 MAPT GRN
5 aphasia 31.2 PRNP MAPT GRN C9orf72
6 ideomotor apraxia 31.0 MBP MAPT GRN
7 frontotemporal lobar degeneration with tdp43 inclusions, grn-related 30.9 MAPT GRN
8 speech and communication disorders 30.4 MAPT GRN C9orf72
9 supranuclear palsy, progressive, 1 30.4 MAPT GRN ACHE
10 behavioral variant of frontotemporal dementia 30.3 MAPT GRN C9orf72
11 semantic dementia 30.3 MAPT GRN C9orf72
12 frontotemporal dementia 29.9 PRNP MAPT GRN C9orf72 ACHE
13 motor neuron disease 29.9 MAPT GRN C9orf72
14 alzheimer disease 29.8 PRNP MAPT GRN BCHE ACHE
15 amyotrophic lateral sclerosis 1 29.7 PRNP MAPT GRN CDR1 C9orf72
16 dementia 29.6 PRNP MAPT GRN C9orf72 BCHE ACHE
17 dysgraphia 11.9
18 gerstmann syndrome 11.8
19 inclusion body myopathy with early-onset paget disease and frontotemporal dementia 11.2
20 agnosia 10.5
21 butyrylcholinesterase deficiency 10.4 BCHE ACHE
22 akinetic mutism 10.4 PRNP MAPT
23 echolalia 10.4 MAPT GRN
24 dyslexia 10.4
25 yemenite deaf-blind hypopigmentation syndrome 10.3
26 hemiplegia 10.3
27 lateral sclerosis 10.3
28 third cranial nerve disease 10.3 PNMA2 MBP
29 frontotemporal dementia and/or amyotrophic lateral sclerosis 1 10.3 MAPT GRN C9orf72
30 panencephalitis, subacute sclerosing 10.3 MBP MAPT
31 oculomotor nerve paralysis 10.3 PNMA2 MBP
32 hand skill, relative 10.3
33 disease of mental health 10.3 MAPT GRN C9orf72
34 ataxia and polyneuropathy, adult-onset 10.2
35 writing disorder 10.2
36 amusia 10.2
37 anosognosia 10.2
38 visual agnosia 10.2
39 corticobasal degeneration 10.2
40 glioma 10.2
41 glial tumor 10.2
42 stroke, ischemic 10.2
43 branchiootic syndrome 1 10.2
44 amnestic disorder 10.2
45 cerebrovascular disease 10.2
46 marchiafava bignami disease 10.2
47 posterior cortical atrophy 10.2
48 multiple sclerosis 10.1
49 migraine with or without aura 1 10.1
50 finger agnosia 10.1

Graphical network of the top 20 diseases related to Agraphia:



Diseases related to Agraphia

Symptoms & Phenotypes for Agraphia

UMLS symptoms related to Agraphia:


other symbolic dysfunction

MGI Mouse Phenotypes related to Agraphia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.17 ACHE C9orf72 CBSL DEDD GRN KIDINS220
2 cellular MP:0005384 10.16 C9orf72 CBSL GRN KIDINS220 MAPK14 MAPT
3 hematopoietic system MP:0005397 10.14 ACHE C9orf72 CBSL DEDD GRN MAPK14
4 mortality/aging MP:0010768 10.1 ACHE BCHE C9orf72 CBSL GRN KIDINS220
5 immune system MP:0005387 10.07 C9orf72 CBSL DEDD GRN MAPK14 MAPT
6 nervous system MP:0003631 10.03 ACHE C9orf72 CBSL DEDD GRN KIDINS220
7 no phenotypic analysis MP:0003012 9.7 ACHE C9orf72 GRN KIDINS220 MAPT PRNP
8 reproductive system MP:0005389 9.56 ACHE BCHE CBSL DEDD GRN MAPK14
9 vision/eye MP:0005391 9.17 ACHE CBSL GRN KIDINS220 MAPT MBP

Drugs & Therapeutics for Agraphia

Drugs for Agraphia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
tannic acid Approved 1401-55-4
2
Benzocaine Approved, Investigational 94-09-7, 1994-09-7 2337

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Handwriting Intervention, With vs. Without a Rightward Bias, in a Junior High School-A Randomized Controlled Study Completed NCT03903614
2 Effectiveness of a Handwriting Intervention With At-Risk Kindergarteners Completed NCT02620098
3 The Effects of a Graphomotor Intervention Program According to a Psychomotor Approach on Quality and Speed of Handwriting in School-Age Children: A Randomized Controlled Trial Recruiting NCT03699800
4 The Effects of a Graphomotor Intervention Program According to a Psychomotor Approach on Graphomotor Competences in Preschool Children: A Randomized Controlled Trial Recruiting NCT03699787
5 Improving Electronic Written Communication in Persons With Aphasia: A Clinical Trial Recruiting NCT03773419
6 The Center for the Neurobiology of Language Recovery (CNLR) Active, not recruiting NCT01927302
7 Treatment for Reading and Writing Deficits Following Acquired Brain Injury Enrolling by invitation NCT03662243

Search NIH Clinical Center for Agraphia

Genetic Tests for Agraphia

Anatomical Context for Agraphia

MalaCards organs/tissues related to Agraphia:

41
Brain, Parietal Lobe, Cortex, Temporal Lobe, Occipital Lobe, Testes, Bone

Publications for Agraphia

Articles related to Agraphia:

(show top 50) (show all 711)
# Title Authors PMID Year
1
Alexia and Agraphia Intervention Following Traumatic Brain Injury: A Single Case Study. 38
31194917 2019
2
The making of a syndrome: The English translation of Gerstmann's first report. 38
31029874 2019
3
Multi-step treatment for acquired alexia and agraphia (part II): a dual-route error scoring system. 38
28421910 2019
4
Multi-step treatment for acquired alexia and agraphia (Part I): efficacy, generalisation, and identification of beneficial treatment steps. 38
28421858 2019
5
Seeing is not believing. 38
30953621 2019
6
Gray Matter Correlates of Finger Gnosis in Children: A VBM Study. 38
30699334 2019
7
Maurice Ravel's dementia: the silence of a genius. 38
30810599 2019
8
Cognitive Rehabilitation of Acquired Calculation Disturbances. 38
31093301 2019
9
Kanji (Morphogram) and Kana (Phonogram) Problem in Japanese Alexia and Agraphia. 38
31220841 2019
10
Alexia and Agraphia from 1861 to 1965. 38
31220840 2019
11
Two year outcomes of poststroke writing and reading disorders. 38
28489413 2018
12
Agraphia with reversible splenial corpus callosum lesion caused by hypoglycemia. 38
29606344 2018
13
Hypothalamic relapse of a cardiac large B-cell lymphoma presenting with memory loss, confabulation, alexia-agraphia, apathy, hypersomnia, appetite disturbances and diabetes insipidus. 38
30150329 2018
14
The nature and treatment of phonological text agraphia. 38
27392251 2018
15
Neuroradiologic correlation with aphasias. Cortico-subcortical map of language. 38
29439808 2018
16
A Case of Nonalcoholic Marchiafava-Bignami Disease with Left-Right Differential Agraphia of Chinese Characters. 38
30283321 2018
17
Molecular neuroimaging in primary progressive aphasia with predominant agraphia. 38
29569990 2018
18
Medial-Vowel Writing Difficulty in Korean Syllabic Writing: A Characteristic Sign of Alzheimer's Disease. 38
29504296 2018
19
Agraphia of the left hand with dysfunction of the left superior parietal region without callosal lesions. 38
29430524 2018
20
Unilateral Apraxic Agraphia without Ideomotor Apraxia from a callosal lesion in a patient with Marchiafava-Bignami disease. 38
29482459 2018
21
The neural substrates of improved phonological processing following successful treatment in a case of phonological alexia and agraphia. 38
29350575 2018
22
Maximising recovery from aphasia with central and peripheral agraphia: The benefit of sequential treatments. 38
29298550 2018
23
Phenotypic variability and neuropsychological findings associated with C9orf72 repeat expansions in a Bulgarian dementia cohort. 38
30550541 2018
24
Cardiac Sarcoidosis as an Uncommon Etiology for Posterior Circulation Stroke Presenting with Alexia without Agraphia. 38
30652036 2018
25
The history of the neurophysiology and neurology of the parietal lobe. 38
29519464 2018
26
Gerstmann syndrome: historic and current perspectives. 38
29519471 2018
27
Revival of Historical Kana Orthography in a Patient with Allographic Agraphia. 38
29491278 2018
28
Frontal Phonological Agraphia and Acalculia with Impaired Verbal Short-Term Memory due to Left Inferior Precentral Gyrus Lesion. 38
29681826 2018
29
[A Case of Kanji Agraphia Resulting from Intracerebral Hemorrhage on the Left Temporal Lobe Associated with Multiple Dural Arteriovenous Fistulas]. 38
29282347 2017
30
Widespread enlarged perivascular spaces associated with dementia and focal brain dysfunction: case report. 38
29212461 2017
31
Agraphia manifesting during a WhatsApp conversation. 38
29169804 2017
32
Gerstmann's syndrome and unilateral optic ataxia in the emergency department. 38
29354229 2017
33
Historical Perspectives on Ancient Greek Derived "a" Prefixed Nomenclature for Acquired Neurocognitive Impairment. 38
28484905 2017
34
Callosal Motor Impersistence: A Novel Disconnection Syndrome. 38
28632524 2017
35
Squaring the round: An unusual progressive graphomotor impairment with post-mortem findings. 38
26362247 2017
36
[Efficacy and safety of cyclophosphamide as a sequential immunotherapy drug for anti-N-methyl-D-aspartate receptor encephalitis in children]. 38
28606234 2017
37
Alexia Without Agraphia: A Rare Entity. 38
28690938 2017
38
Transient Gerstmann syndrome as manifestation of stroke: Case report and brief literature review. 38
29213512 2017
39
[Brodmann Areas 39 and 40: Human Parietal Association Area and Higher Cortical Function]. 38
28424400 2017
40
Yellow fever vaccine-associated neurological disease, a suspicious case. 38
28254833 2017
41
Historical evidence supports El Greco's depiction of a neurological condition in his attributed self-portrait. 38
28017236 2017
42
A Case of Anoxic Brain Injury Presenting with Agraphia of kanji in the Foreground. 38
28611641 2017
43
Neural substrates of sublexical processing for spelling. 38
27838547 2017
44
Levodopa-responsive depression associated with corticobasal degeneration: a case report. 38
28458551 2017
45
A 71-Year-Old Man Presenting with Headache, Blurry Vision and Alexia without Agraphia. 38
27647576 2016
46
Cortical relapses in multiple sclerosis. 38
25791367 2016
47
Characteristics of Agraphia in Chinese Patients with Alzheimer's Disease and Amnestic Mild Cognitive Impairment. 38
27364791 2016
48
Right hemisphere dominance for language in a woman with schizophrenia and a porencephalic cyst of the left hemisphere. 38
27283036 2016
49
Glioblastoma Presenting with Pure Alexia and Palinopsia Involving the Left Inferior Occipital Gyrus and Visual Word Form Area Evaluated with Functional Magnetic Resonance Imaging and Diffusion Tensor Imaging Tractography. 38
26748167 2016
50
Pure agraphia after infarction in the superior and middle portions of the left precentral gyrus: Dissociation between Kanji and Kana. 38
26597609 2016

Variations for Agraphia

Expression for Agraphia

Search GEO for disease gene expression data for Agraphia.

Pathways for Agraphia

GO Terms for Agraphia

Cellular components related to Agraphia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 PVR PRTN3 MAPT MAPK14 GRN C9orf72
2 main axon GO:0044304 8.62 MAPT C9orf72

Biological processes related to Agraphia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 stress granule assembly GO:0034063 8.62 MAPT C9orf72

Molecular functions related to Agraphia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 amyloid-beta binding GO:0001540 9.43 PRNP BCHE ACHE
2 cholinesterase activity GO:0004104 9.16 BCHE ACHE
3 enzyme binding GO:0019899 9.1 PRTN3 PPP3CA MAPT MAPK14 IQCB1 BCHE
4 acetylcholinesterase activity GO:0003990 8.96 BCHE ACHE

Sources for Agraphia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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