Ah Amyloidosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: AHM002 MIFTS: 18	Ah Amyloidosis Categories: Blood diseases, Bone diseases, Genetic diseases, Immune diseases, Metabolic diseases, Nephrological diseases, Neuronal diseases, Rare diseases
Tissues Related diseases Publications Drugs Expand all tables

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Aliases & Classifications for Ah Amyloidosis

MalaCards integrated aliases for Ah Amyloidosis:

Name: Ah Amyloidosis ⁵⁸

Heavy Chain Amyloidosis ⁵⁸

Characteristics:

Orphanet epidemiological data:

⁵⁸

ah amyloidosis
Inheritance: Not applicable;

Classifications:

MalaCards categories:
Global: Rare diseases Metabolic diseases Genetic diseases
Anatomical: Nephrological diseases Bone diseases Neuronal diseases Blood diseases Immune diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Endocrine, nutritional and metabolic diseases

Metabolic disorders

Amyloidosis

Amyloidosis, unspecified

Orphanet: ⁵⁸

Rare renal diseases

Rare systemic and rhumatological diseases

External Ids:

ICD10 via Orphanet ³³ E85.9

Orphanet ⁵⁸ ORPHA442582

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Summaries for Ah Amyloidosis

MalaCards based summary : Ah Amyloidosis, also known as heavy chain amyloidosis, is related to amyloidosis and nephrotic syndrome. The drugs Altretamine and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include bone, t cells and heart.

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Related Diseases for Ah Amyloidosis

Diseases in the Amyloidosis family:

Al Amyloidosis	Amyloidosis Aa
Hereditary Amyloidosis	Primary Localized Amyloidosis
Ah Amyloidosis

Diseases related to Ah Amyloidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)

#	Related Disease	Score
1	amyloidosis	10.4
2	nephrotic syndrome	10.2
3	al amyloidosis	10.2
4	lymphoplasmacytic lymphoma	10.0
5	lymphoproliferative syndrome	10.0
6	plasma cell neoplasm	10.0
7	t-cell large granular lymphocyte leukemia	9.9
8	corneal dystrophy	9.9
9	iga glomerulonephritis	9.9
10	eye disease	9.9
11	monoclonal gammopathy of uncertain significance	9.9
12	lattice corneal dystrophy	9.9
13	light chain deposition disease	9.9

Graphical network of the top 20 diseases related to Ah Amyloidosis:

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Symptoms & Phenotypes for Ah Amyloidosis

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Drugs & Therapeutics for Ah Amyloidosis

Drugs for Ah Amyloidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Altretamine

Approved

Early Phase 1

645-05-6

2123

Synonyms:

2,4, 6-Tris(dimethylamino)-1,3,5-triazine

2,4,6-Tris(dimethylami

2,4,6-tris(dimethylamino)-1,3,5-triazine

2,4,6-Tris(dimethylamino)-1,3,5-triazine

2,4,6-tris(dimethylamino)-s-triazine

2,4,6-Tris(dimethylamino)-s-triazine

2,4,6-Tris(dimethylamino)-S-triazine

2-N,2-N,4-N,4-N,6-N,6-N-hexamethyl-1,3,5-triazine-2,4,6-triamine

549835_ALDRICH

645-05-6

A 8723

A0567/0026158

A8723_SIGMA

AB00052308

AC-12006

AC1L1CYX

AI3-50852

AKOS001729401

Altretamin

Altretamina

Altretamina [INN-Spanish]

altretamine

Altretamine

Altrétamine

Altretamine (USP/INN)

Altretamine [USAN:INN:BAN]

Altretamine bellon brand

Altretamine Bellon Brand

Altretamine chiesi brand

Altretamine Chiesi Brand

Altretamine wassermann brand

Altretamine Wassermann Brand

Altretaminum

Altretaminum [INN-Latin]

Bellon brand OF altretamine

Bellon Brand of Altretamine

BPBio1_001004

BRD-K67043667-001-04-1

BRN 0195058

BSPBio_000912

C9H18N6

CAS-654-05-6

CCRIS 5492

CHEBI:24564

CHEMBL1455

ChemDiv2_005185

Chiesi brand OF altretamine

Chiesi Brand of Altretamine

CID2123

CPD000058181

D006585

D02841

DB00488

DivK1c_000772

EINECS 211-428-4

ENT 50852

EU-0100083

FT-0083576

Hemel

Hexalen

Hexalen (TN)

Hexalen, Altretamine

Hexamethylmelamine

HEXAMETHYLMELAMINE

Hexastat

Hexinawas

HMM

HMS1383L15

HMS1570N14

HMS1922C05

HMS2090G17

HMS2092H16

HMS502G14

HSDB 7559

HTM

HXM

I06-0604

IDI1_000772

IDI1_003900

InChI=1/C9H18N6/c1-13(2)7-10-8(14(3)4)12-9(11-7)15(5)6/h1-6H

KB-913

KBio1_000772

KBio2_001788

KBio2_004356

KBio2_006924

KBio3_002042

KBioGR_001388

KBioSS_001788

Lopac0_000083

Lopac-A-8723

LS-1549

MGI pharma brand OF altretamine

MGI Pharma Brand of Altretamine

MLS000069621

MLS001076123

MolPort-002-111-210

N,N,N',N',N'',N''-hexamethyl-1,3,5-triazine-2,4,6-triamine

N~2~,N~2~,N~4~,N~4~,N~6~,N~6~-Hexamethyl-1,3,5-triazine-2,4,6-triamine

NC 195

NCGC00015100-01

NCGC00015100-02

NCGC00015100-03

NCGC00015100-06

NCGC00015100-11

NCGC00021216-03

NCGC00021216-04

NCGC00021216-05

NCGC00021216-06

NCGC00021216-07

NCI60_000871

NCI-C50259

NINDS_000772

no)-s-triazine

NSC 13875

NSC13875

NSC-13875

Prestwick0_000946

Prestwick1_000946

Prestwick2_000946

Prestwick3_000946

Rhone Poulenc Rorer Brand of Altretamine

Rhône poulenc rorer brand OF altretamine

Rhone-Poulenc Rorer Brand of Altretamine

Rhône-poulenc rorer brand OF altretamine

S1278_Selleck

SAM002564241

SMR000058181

SPBio_000754

SPBio_003071

Spectrum_001308

SPECTRUM1503065

Spectrum2_000907

Spectrum3_000951

Spectrum4_001064

Spectrum5_001092

ST086739

STK749184

UNII-Q8BIH59O7H

Wassermann brand OF altretamine

Wassermann Brand of Altretamine

WLN: T6N CN ENJ BN1&1 DN1&1 FN1&1

ZINC00000905

Vaccines

Early Phase 1

Plasma-lyte 148

Early Phase 1

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	A Pilot Study of Dendritic Cell DKK1 Vaccine for Patients With Monoclonal Gammopathy and Stable or Smoldering Myeloma	Not yet recruiting	NCT03591614	Early Phase 1

Search NIH Clinical Center for Ah Amyloidosis

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Genetic Tests for Ah Amyloidosis

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Anatomical Context for Ah Amyloidosis

MalaCards organs/tissues related to Ah Amyloidosis:

⁴⁰

Bone, T Cells, Heart, B Cells

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Publications for Ah Amyloidosis

Articles related to Ah Amyloidosis:

(show all 28)

#	Title	Authors	PMID	Year
1	IgGκ light and heavy chain amyloidosis secondary to a B-cell lymphoproliferative disorder, whole picture on a renal biopsy. ⁶¹	Ville S...Cantarovich D	31726478	2020
2	Heavy Lifting: Nomenclature and Novel Therapy for Gamma Heavy Chain Disease and Other Heavy Chain Disorders. ⁶¹	Singer S...Rosko AE	32245744	2020
3	Underlying IgM heavy chain amyloidosis in treatment-refractory IgA nephropathy: A case report. ⁶¹	Wu HT...Li MX	31624754	2019
4	Heavy Chain Fibrillary Glomerulonephritis: A Case Report. ⁶¹	Nasr SH...Leung N	30955945	2019
5	Monoclonal Immunoglobulin Deposition Disease and Related Diseases. ⁶¹	Kanzaki G...Shimizu A	30918151	2019
6	A Case of T-Cell Large Granular Lymphocytic Leukemia and Renal Immunoglobulin Heavy Chain Amyloidosis. ⁶¹	Fu J...Comenzo RL	30631033	2019
7	Heavy-chain amyloidosis in gastroduodenal biopsies - the histopathological features. ⁶¹	Ichimata S...Kanno H	31343299	2019
8	A case report - renal heavy chain amyloidosis and T-cell large granular lymphocytic leukaemia. ⁶¹	Fu J...Comenzo R	31343367	2019
9	Usefulness of gastroduodenal biopsy in the differential diagnosis of systemic AH amyloidosis from systemic AL amyloidosis. ⁶¹	Ichimata S...Kanno H	29660165	2018
10	Renal AH Amyloidosis Associated With a Truncated Immunoglobulin Heavy Chain Undetectable by Immunostaining. ⁶¹	Manabe S...Nagata M	26362695	2015
11	Bortezomib plus dexamethasone results in a late organ response in primary heavy-chain amyloidosis without a hematologic response. ⁶¹	Hassoun Y...Baz R	25732670	2015
12	Heavy and Light chain amyloidosois presenting as complete heart block: A rare presentation of a rare disease. ⁶¹	Priyamvada PS...Parameswaran S	25838650	2015
13	Rituximab-cyclophosphamide-dexamethasone is highly effective in patients with monoclonal Ig deposit-related glomerulopathy and indolent non-Hodgkin lymphomas. ⁶¹	Perry M...Faguer S	25043930	2014
14	Proximal tubulopathies associated with monoclonal light chains: the spectrum of clinicopathologic manifestations and molecular pathogenesis. ⁶¹	Herrera GA	25268200	2014
15	Non-light-chain immunoglobulin amyloidosis: time to expand or refine the spectrum to include light+heavy chain amyloidosis? ⁶¹	Picken MM	23446254	2013
16	The diagnosis and characteristics of renal heavy-chain and heavy/light-chain amyloidosis and their comparison with renal light-chain amyloidosis. ⁶¹	Nasr SH...Leung N	23302715	2013
17	Heavy-chain amyloidosis in TGFBI-negative and gelsolin-negative atypical lattice corneal dystrophy. ⁶¹	Pradhan MA...Vincent AL	21743312	2011
18	Mass spectrometry-based proteomic diagnosis of renal immunoglobulin heavy chain amyloidosis. ⁶¹	Sethi S...Dogan A	20876678	2010
19	Rituximab therapy in nephrotic syndrome due to AH amyloidosis. ⁶¹	Katoh N...Ikeda S	19590993	2009
20	AH amyloidosis associated with an immunoglobulin heavy chain variable region (VH1) fragment: a case report. ⁶¹	Miyazaki D...Ikeda S	18484339	2008
21	Immunoglobulin light and heavy chain amyloidosis AL/AH: renal pathology and differential diagnosis. ⁶¹	Picken MM	17075228	2007
22	AH amyloidosis associated with lymphoplasmacytic lymphoma secreting a monoclonal gamma heavy chain carrying an unusual truncated D segment. ⁶¹	Gono T...Ikeda S	16632032	2006
23	Metachronous development of nonamyloidogenic [lambda] light chain deposition disease and IgG heavy chain amyloidosis in the same patient. ⁶¹	Copeland JN...Nadasdy T	14576484	2003
24	Immunoglobulin heavy chain can be amyloidogenic: morphologic characterization including immunoelectron microscopy. ⁶¹	Mai HL...Truong LD	12657941	2003
25	Renal manifestations of plasma cell dyscrasias: an appraisal from the patients' bedside to the research laboratory. ⁶¹	Herrera GA	10919389	2000
26	Primary amyloidosis associated with a novel heavy-chain fragment (AH amyloidosis). ⁶¹	Solomon A...Murphy C	8141123	1994
27	Immunoglobulin heavy-chain-associated amyloidosis. ⁶¹	Eulitz M...Solomon A	2118650	1990
28	The pathogenesis and biochemistry of amyloidosis. ⁶¹	Cohen AS...Connors LH	3550020	1987

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Genes for Ah Amyloidosis

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Variations for Ah Amyloidosis

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Expression for Ah Amyloidosis

Search GEO for disease gene expression data for Ah Amyloidosis.

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Pathways for Ah Amyloidosis

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GO Terms for Ah Amyloidosis

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Sources for Ah Amyloidosis

¹ BioSystems

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³ CDC

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²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

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³⁰ HMDB

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³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

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⁴⁰ MalaCards

⁴¹ MedGen

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⁴³ MeSH

⁴⁴ MESH via Orphanet

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⁴⁷ NCBI Bookshelf

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⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

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⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

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⁶¹ PubMed

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⁶⁴ R&D Systems

⁶⁵ Reactome

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⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia