MCID: AHM002
MIFTS: 18

Ah Amyloidosis

Categories: Blood diseases, Bone diseases, Genetic diseases, Immune diseases, Metabolic diseases, Nephrological diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Ah Amyloidosis

MalaCards integrated aliases for Ah Amyloidosis:

Name: Ah Amyloidosis 59
Heavy Chain Amyloidosis 59

Characteristics:

Orphanet epidemiological data:

59
ah amyloidosis
Inheritance: Not applicable;

Classifications:



External Ids:

ICD10 via Orphanet 34 E85.9
Orphanet 59 ORPHA442582

Summaries for Ah Amyloidosis

MalaCards based summary : Ah Amyloidosis, also known as heavy chain amyloidosis, is related to amyloidosis and nephrotic syndrome. The drugs Altretamine and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include bone, t cells and heart.

Related Diseases for Ah Amyloidosis

Diseases in the Amyloidosis family:

Al Amyloidosis Amyloidosis Aa
Hereditary Amyloidosis Primary Localized Amyloidosis
Ah Amyloidosis

Diseases related to Ah Amyloidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 amyloidosis 10.4
2 nephrotic syndrome 10.2
3 al amyloidosis 10.2
4 lymphoplasmacytic lymphoma 10.0
5 lymphoproliferative syndrome 10.0
6 t-cell large granular lymphocyte leukemia 9.9
7 lymphocytic leukemia 9.9
8 corneal dystrophy 9.9
9 eye disease 9.9
10 lattice corneal dystrophy 9.9
11 light chain deposition disease 9.9
12 hematopoietic stem cell transplantation 9.9

Graphical network of the top 20 diseases related to Ah Amyloidosis:



Diseases related to Ah Amyloidosis

Symptoms & Phenotypes for Ah Amyloidosis

Drugs & Therapeutics for Ah Amyloidosis

Drugs for Ah Amyloidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Altretamine Approved Early Phase 1 645-05-6 2123
2 Vaccines Early Phase 1
3 Immunologic Factors Early Phase 1
4 Plasma-lyte 148 Early Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Pilot Study of Dendritic Cell DKK1 Vaccine for Patients With Monoclonal Gammopathy and Stable or Smoldering Myeloma Not yet recruiting NCT03591614 Early Phase 1

Search NIH Clinical Center for Ah Amyloidosis

Genetic Tests for Ah Amyloidosis

Anatomical Context for Ah Amyloidosis

MalaCards organs/tissues related to Ah Amyloidosis:

41
Bone, T Cells, Heart

Publications for Ah Amyloidosis

Articles related to Ah Amyloidosis:

(show all 25)
# Title Authors PMID Year
1
Heavy Chain Fibrillary Glomerulonephritis: A Case Report. 38
30955945 2019
2
A case report - renal heavy chain amyloidosis and T-cell large granular lymphocytic leukaemia. 38
31343367 2019
3
Monoclonal Immunoglobulin Deposition Disease and Related Diseases. 38
30918151 2019
4
A Case of T-Cell Large Granular Lymphocytic Leukemia and Renal Immunoglobulin Heavy Chain Amyloidosis. 38
30631033 2019
5
Heavy-chain amyloidosis in gastroduodenal biopsies - the histopathological features. 38
31343299 2019
6
Usefulness of gastroduodenal biopsy in the differential diagnosis of systemic AH amyloidosis from systemic AL amyloidosis. 38
29660165 2018
7
Renal AH Amyloidosis Associated With a Truncated Immunoglobulin Heavy Chain Undetectable by Immunostaining. 38
26362695 2015
8
Bortezomib plus dexamethasone results in a late organ response in primary heavy-chain amyloidosis without a hematologic response. 38
25732670 2015
9
Heavy and Light chain amyloidosois presenting as complete heart block: A rare presentation of a rare disease. 38
25838650 2015
10
Rituximab-cyclophosphamide-dexamethasone is highly effective in patients with monoclonal Ig deposit-related glomerulopathy and indolent non-Hodgkin lymphomas. 38
25043930 2014
11
Proximal tubulopathies associated with monoclonal light chains: the spectrum of clinicopathologic manifestations and molecular pathogenesis. 38
25268200 2014
12
Non-light-chain immunoglobulin amyloidosis: time to expand or refine the spectrum to include light+heavy chain amyloidosis? 38
23446254 2013
13
The diagnosis and characteristics of renal heavy-chain and heavy/light-chain amyloidosis and their comparison with renal light-chain amyloidosis. 38
23302715 2013
14
Heavy-chain amyloidosis in TGFBI-negative and gelsolin-negative atypical lattice corneal dystrophy. 38
21743312 2011
15
Mass spectrometry-based proteomic diagnosis of renal immunoglobulin heavy chain amyloidosis. 38
20876678 2010
16
Rituximab therapy in nephrotic syndrome due to AH amyloidosis. 38
19590993 2009
17
AH amyloidosis associated with an immunoglobulin heavy chain variable region (VH1) fragment: a case report. 38
18484339 2008
18
Immunoglobulin light and heavy chain amyloidosis AL/AH: renal pathology and differential diagnosis. 38
17075228 2007
19
AH amyloidosis associated with lymphoplasmacytic lymphoma secreting a monoclonal gamma heavy chain carrying an unusual truncated D segment. 38
16632032 2006
20
Metachronous development of nonamyloidogenic [lambda] light chain deposition disease and IgG heavy chain amyloidosis in the same patient. 38
14576484 2003
21
Immunoglobulin heavy chain can be amyloidogenic: morphologic characterization including immunoelectron microscopy. 38
12657941 2003
22
Renal manifestations of plasma cell dyscrasias: an appraisal from the patients' bedside to the research laboratory. 38
10919389 2000
23
Primary amyloidosis associated with a novel heavy-chain fragment (AH amyloidosis). 38
8141123 1994
24
Immunoglobulin heavy-chain-associated amyloidosis. 38
2118650 1990
25
The pathogenesis and biochemistry of amyloidosis. 38
3550020 1987

Variations for Ah Amyloidosis

Expression for Ah Amyloidosis

Search GEO for disease gene expression data for Ah Amyloidosis.

Pathways for Ah Amyloidosis

GO Terms for Ah Amyloidosis

Sources for Ah Amyloidosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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