MCID: ADS004
MIFTS: 45

Aids Dementia Complex

Categories: Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Aids Dementia Complex

MalaCards integrated aliases for Aids Dementia Complex:

Name: Aids Dementia Complex 54 56 74
Aids Related Cognitive Impairment 54
Adc 54

Classifications:



External Ids:

UMLS 74 C0001849

Summaries for Aids Dementia Complex

MalaCards based summary : Aids Dementia Complex, also known as aids related cognitive impairment, is related to acquired immunodeficiency syndrome and spondyloarthropathy 1. An important gene associated with Aids Dementia Complex is CXCL12 (C-X-C Motif Chemokine Ligand 12), and among its related pathways/superpathways are Akt Signaling and PAK Pathway. The drugs Atorvastatin and Darunavir have been mentioned in the context of this disorder. Affiliated tissues include brain, monocytes and prostate, and related phenotypes are cellular and hematopoietic system

Wikipedia : 77 HIV-associated neurocognitive disorders (HAND) are neurological disorders associated with HIV infection... more...

Related Diseases for Aids Dementia Complex

Diseases related to Aids Dementia Complex via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 171)
# Related Disease Score Top Affiliating Genes
1 acquired immunodeficiency syndrome 29.8 B2M ITIH4 TNF
2 spondyloarthropathy 1 29.7 B2M TNF
3 lymphoma, non-hodgkin, familial 29.0 B2M CXCL12 CXCR4
4 human immunodeficiency virus infectious disease 28.9 B2M CXCL12 CXCR4 ITIH4 TNF
5 human immunodeficiency virus type 1 28.2 B2M CCR3 CXCL12 CXCR4 ITIH4 TNF
6 aids - neurological complications 11.2
7 leukoencephalopathy with ataxia 11.1
8 adenosquamous lung carcinoma 11.1
9 dementia 11.0
10 endometrial cancer 10.2
11 lymphoma 10.2
12 encephalopathy 10.2
13 post-transplant lymphoproliferative disease 10.2 B2M TNF
14 pleural tuberculosis 10.2 B2M TNF
15 breast cancer 10.2
16 cervical cancer 10.2
17 adenocarcinoma 10.2
18 monoclonal gammopathy of uncertain significance 10.2 B2M TNF
19 orofacial granulomatosis 10.1 CCR3 TNF
20 hemorrhagic fever with renal syndrome 10.1 B2M TNF
21 glioblastoma 10.1
22 inner ear disease 10.1 B2M TNF
23 ileitis 10.1 CCR3 TNF
24 retinal ischemia 10.1 CXCL12 TNF
25 arthropathy 10.1 B2M TNF
26 prostate cancer 10.1
27 prostate cancer, hereditary, 8 10.1
28 prostate cancer, hereditary, 6 10.1
29 pancreas adenocarcinoma 10.1
30 squamous cell carcinoma 10.1
31 rectum cancer 10.1
32 glioblastoma multiforme 10.1
33 leukocyte disease 10.1 B2M TNF
34 limb ischemia 10.1 CXCL12 TNF
35 multiple sclerosis 10.1
36 kaposi sarcoma 10.1
37 sarcoma 10.1
38 cytomegalovirus infection 10.1 B2M TNF
39 glioma susceptibility 1 10.0
40 pancreatic cancer 10.0
41 bronchial disease 10.0 CCR3 TNF
42 peritonitis 10.0 B2M TNF
43 bronchitis 10.0 CCR3 TNF
44 membranous nephropathy 10.0 B2M TNF
45 human herpesvirus 8 10.0
46 myositis 10.0
47 hemangiopericytoma, malignant 10.0
48 hydrocephalus, normal-pressure 10.0
49 stroke, ischemic 10.0
50 pancreatitis 10.0

Graphical network of the top 20 diseases related to Aids Dementia Complex:



Diseases related to Aids Dementia Complex

Symptoms & Phenotypes for Aids Dementia Complex

MGI Mouse Phenotypes related to Aids Dementia Complex:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.8 B2M CCR3 CXCL12 CXCR4 ITIH4 TNF
2 hematopoietic system MP:0005397 9.65 B2M CCR3 CXCL12 CXCR4 TNF
3 immune system MP:0005387 9.55 B2M CCR3 CXCL12 CXCR4 TNF
4 liver/biliary system MP:0005370 9.26 B2M CXCL12 ITIH4 TNF
5 neoplasm MP:0002006 8.92 B2M CXCR4 ITIH4 TNF

Drugs & Therapeutics for Aids Dementia Complex

Drugs for Aids Dementia Complex (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 144)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Atorvastatin Approved Phase 4 134523-00-5 60823
2
Darunavir Approved Phase 4,Phase 2,Phase 3 206361-99-1, 635728-49-3 213039
3
Ritonavir Approved, Investigational Phase 4,Phase 2,Phase 3 155213-67-5 392622
4
Lopinavir Approved Phase 4,Phase 2,Phase 3 192725-17-0 92727
5
Formaldehyde Approved, Vet_approved Phase 4 50-00-0 712
6
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
7
Racepinephrine Approved Phase 4 329-65-7 838
8
Cobicistat Approved Phase 4 1004316-88-4
9 Anti-HIV Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
10 Anti-Retroviral Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
11 Hypolipidemic Agents Phase 4
12 Anticholesteremic Agents Phase 4
13 Lipid Regulating Agents Phase 4
14 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
15 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
16 Pharmaceutical Solutions Phase 4,Phase 2,Phase 1
17 HIV Protease Inhibitors Phase 4,Phase 2,Phase 3,Phase 1
18 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 2,Phase 3
19
protease inhibitors Phase 4,Phase 2,Phase 3,Phase 1
20 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
21 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
22 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 2,Phase 3
23 Vasoconstrictor Agents Phase 4
24 Epinephryl borate Phase 4
25
Methylphenidate Approved, Investigational Phase 3 113-45-1 4158
26
Dopamine Approved Phase 3,Phase 2 62-31-7, 51-61-6 681
27
Zidovudine Approved Phase 3,Phase 2,Phase 1,Not Applicable 30516-87-1 35370
28
Stavudine Approved, Investigational Phase 3 3056-17-5 18283
29
Abacavir Approved, Investigational Phase 3,Phase 2 136470-78-5 441300 65140
30
Etravirine Approved Phase 2, Phase 3 269055-15-4 193962
31
Nelfinavir Approved Phase 2, Phase 3 159989-64-7 64143
32
Amprenavir Approved, Investigational Phase 2, Phase 3 161814-49-9 65016
33
Maraviroc Approved, Investigational Phase 2, Phase 3,Phase 3 376348-65-1 3002977
34
Emtricitabine Approved, Investigational Phase 2, Phase 3 143491-57-0 60877
35
Fosamprenavir Approved Phase 2, Phase 3 226700-79-4 131536
36
Tipranavir Approved, Investigational Phase 2, Phase 3 174484-41-4 65027
37
Tenofovir Approved, Experimental, Investigational Phase 2, Phase 3 147127-20-6 464205
38
Saquinavir Approved, Investigational Phase 2, Phase 3 127779-20-8 60787
39
Lamivudine Approved, Investigational Phase 2, Phase 3,Phase 1 134678-17-4 60825
40
Delavirdine Approved Phase 2, Phase 3 136817-59-9 5625
41
Nevirapine Approved Phase 2, Phase 3 129618-40-2 4463
42
Efavirenz Approved, Investigational Phase 2, Phase 3 154598-52-4 64139
43
Enfuvirtide Approved, Investigational Phase 2, Phase 3 159519-65-0 16130199
44
Benzocaine Approved, Investigational Phase 3,Phase 2 1994-09-7, 94-09-7 2337
45
tannic acid Approved Phase 3,Phase 2 1401-55-4
46
Aldesleukin Approved Phase 3 110942-02-4, 85898-30-2
47 Central Nervous System Stimulants Phase 3
48 Neurotransmitter Agents Phase 3,Phase 2
49 Dopamine Agents Phase 3,Phase 2
50 Neurotransmitter Uptake Inhibitors Phase 3

Interventional clinical trials:

(show all 48)
# Name Status NCT ID Phase Drugs
1 Modulation of Monocyte Activation by Atorvastatin in HIV Infection Completed NCT01263938 Phase 4 Atorvastatin
2 Downmodulating Monocyte Activation for HIV-1 Associated Neurocognitive Disorders (HAND) Completed NCT01600170 Phase 4 Atorvastatin (generic Lipitor);placebo
3 SOLFAMU Study of Nasal Brushing Collected OLFActory MUcosa Samples in the Diagnosis of Human Encephalopathies Recruiting NCT02951559 Phase 4
4 Effect of Cobicistat Versus Ritonavir Boosting on the Brain Permeation of Darunavir in HIV-infected Individuals Terminated NCT02503462 Phase 4 Darunavir;ritonavir;cobicistat
5 HIV - Monotherapy in Switzerland (MOST-ch) Terminated NCT00531986 Phase 4 Lopinavir-Monotherapy;HAART
6 A Study Comparing Long-acting Methylphenidate (ConcertaTM) vs. Placebo in the Treatment of Memory Loss Due to HIV Unknown status NCT01599975 Phase 3 Long acting methylphenidate;Long acting methylphenidate;Matched placebo
7 A Multicenter Placebo-Controlled Double-Blind Trial to Evaluate Azidothymidine (AZT) Treatment of the AIDS Dementia Complex and Central Nervous System (CNS) Human Immunodeficiency Virus (HIV) Infection Completed NCT00000702 Phase 3 Zidovudine
8 An Open Trial of Zidovudine (AZT) Treatment of the AIDS Dementia Complex in Patients With AIDS or Low CD4+ Lymphocyte Counts Completed NCT00000709 Phase 3 Zidovudine
9 A Study to Evaluate the Use of Stavudine (d4T) to Treat AIDS Dementia Complex Completed NCT00002246 Phase 3 Stavudine
10 A Phase III, Randomized, Double-Blind, Multicentre Study to Evaluate the Safety and Efficacy of 1592U89 in Patients With AIDS Dementia Complex Completed NCT00002163 Phase 3 Abacavir sulfate
11 Clinical Trial of CNS-targeted HAART (CIT2) Completed NCT00624195 Phase 2, Phase 3 FDA Approved Antiretroviral Therapy (see list below)
12 Interleukin-2 Plus Antiretroviral Therapy for HIV-Infected Patients With Low CD4+ Counts (SILCAAT Study) Completed NCT00013611 Phase 3 Proleukin
13 An International Study to Evaluate Recombinant Interleukin-2 in HIV Positive Patients Taking Anti-retroviral Therapy Completed NCT00004978 Phase 3 Recombinant interleukin-2 (rIL-2)
14 Maraviroc and NeuroAIDS Pathogenesis Recruiting NCT02159027 Phase 2, Phase 3 Maraviroc;Placebo
15 Safety and Effectiveness of Giving CPI-1189 to HIV-Infected Patients With AIDS Dementia Unknown status NCT00002414 Phase 2 CPI-1189
16 Comparison of 2',3'-Dideoxyinosine (Didanosine, ddI) and Zidovudine in Therapy of Patients With the AIDS Dementia Complex Completed NCT00000657 Phase 2 Zidovudine;Didanosine
17 A Study to Evaluate the Use of Memantine In Combination With Anti-HIV Drugs to Treat AIDS Dementia Complex (ADC) Completed NCT00000867 Phase 2 Memantine
18 Ferumoxytol-enhanced Imaging and Mapping in neuroAIDS Completed NCT02678767 Phase 2 Ferumoxytol
19 Effect of Cenicriviroc on HIV Neurocognitive Impairment Completed NCT02128828 Phase 2 cenicriviroc
20 A Study of Thioctic Acid and Deprenyl in HIV-Infected Patients With Dementia Completed NCT00002154 Phase 2 Thioctic acid;Selegiline hydrochloride
21 Safety and Effectiveness of the Selegiline "Patch" for Decreased Mental Function in HIV Patients Completed NCT00013585 Phase 2 Selegiline hydrochloride
22 Intranasal Insulin for the Treatment of HAND Recruiting NCT03081117 Phase 1, Phase 2 Insulin, intranasal;Placebo, intranasal
23 Effect of Galantamine on Inflammation and Cognition Recruiting NCT03384784 Phase 2 Galantamine;Placebo
24 Minocycline for HIV+ Cognitive Impairment in Uganda Terminated NCT00855062 Phase 1, Phase 2 minocycline;minocycline placebo capsule
25 Randomized, Double-Blind, Placebo-Controlled Trial of Nimodipine for the Neurological Manifestations of HIV-1 Completed NCT00000738 Phase 1 Nimodipine;Zidovudine
26 Safety and Effectiveness of CPI-1189 in HIV-Infected Males on Combination Anti-HIV Drug Therapy Completed NCT00002209 Phase 1 CPI-1189
27 Parallel Group, Placebo-Controlled, Tolerability, Safety, and Efficacy Study of OPC-14117 in HIV Dementia Completed NCT00002148 Phase 1 OPC 14117
28 Ferumoxytol-enhanced Brain MRI in HIV-associated Neurocognitive Disorders Completed NCT01665846 Phase 1 Ferumoxytol
29 Positron Emission Tomography (PET) Imaging of Glial Activation in Psychotic Disease States Terminated NCT03257592 Phase 1
30 A Prospective Observational Trial to Determine Cardiovascular Diseases in HIV-infected Patients Unknown status NCT02291081
31 A Pilot Study To Evaluate the Effect of Retrovir (Zidovudine: AZT) in the Treatment of Human Immunodeficiency Virus (HIV) Associated Dementia and Neuromuscular Diseases Completed NCT00002044 Not Applicable Zidovudine
32 HIV-1 Specific Immune Responses in Thai Individuals With HIV Dementia Completed NCT00777426
33 Mental Ability Challenge Study in Adults With and Without HIV Completed NCT03244488 Scopolamine Injectable Product;Mecamylamine Pill
34 A Third-Party Blinded, Placebo Controlled Comparative Study of AS-101 Administered Intravenously in HIV Positive Patients With Advanced Disease Completed NCT00002033 Not Applicable Zidovudine;AS-101
35 The Prevalence of Neurocognitive Disorder in a Primary Care-based HIV Cohort Compared to a HIV-negative Control Cohort - Completed NCT01434563
36 Men Who Have Sex With Men (MSM) Neurocog 1&2 Study Completed NCT01508559
37 A Study of Decreased Mental Function Associated With HIV Completed NCT00027040 Not Applicable Selegiline hydrochloride
38 HIV Cohort Study At Johns Hopkins University, University of North Carolina at Chapel Hill and Vanderbilt University Completed NCT01339416
39 Neurocognitive Impairment and Psychiatric Comorbidities in HIV-1 Completed NCT00476671
40 Palliative Care in People Living With HIV/AIDS: Integrating Into Standard of Care Completed NCT01775436 Not Applicable
41 Evaluation of the Role of OCT in the Detection of HIV-associated Neurocognitive Disorder Recruiting NCT02431091 Not Applicable
42 Individualized Cognitive Training in HIV Recruiting NCT03122288 Not Applicable
43 Effects of VSL#3 on Neuro-cognitive Profile of HIV Patients Recruiting NCT02276326 Not Applicable
44 Prevalence and Predictors of Neurocognitive Impairment Among HIV-infected Patients Active, not recruiting NCT00893815
45 PET Imaging of the Dopaminergic and Serotonergic Systems in Treated HIV Positive Subjects Enrolling by invitation NCT03581305
46 Mild Neurocognitive Disorder in HIV Infection of the Brain Terminated NCT01547754
47 PET Evaluation of Brain Peripheral Benzodiazepine Receptors Using [11C]PBR28 in HIV-Seropositive Patients With (MCMD) Terminated NCT00459693 Not Applicable [11C]PBR28
48 Efficacy of Neuro-HAART in Patients With HIV Terminated NCT01434654

Search NIH Clinical Center for Aids Dementia Complex

Genetic Tests for Aids Dementia Complex

Anatomical Context for Aids Dementia Complex

MalaCards organs/tissues related to Aids Dementia Complex:

42
Brain, Monocytes, Prostate, Thyroid, Testes, T Cells, Cortex

Publications for Aids Dementia Complex

Articles related to Aids Dementia Complex:

(show top 50) (show all 192)
# Title Authors Year
1
Development and in vivo evaluation of an implantable nano-enabled multipolymeric scaffold for the management of AIDS dementia complex (ADC). ( 26456249 )
2015
2
Effects of HIV-1 tat on secretion of TNF-α and IL-1β by U87 cells in AIDS patients with or without AIDS dementia complex. ( 24625401 )
2014
3
CNS toxoplasmosis induced hydrocephalus revisited and a brief review of AIDS dementia complex. ( 23749026 )
2013
4
What's in a name? AIDS dementia complex, HIV-associated dementia, HIV-associated neurocognitive disorder or HIV encephalopathy. ( 22722724 )
2012
5
Formulation development and in vitro evaluation of didanosine-loaded nanostructured lipid carriers for the potential treatment of AIDS dementia complex. ( 20923388 )
2011
6
HIV-1B gp120 genes from one patient with AIDS dementia complex can affect the secretion of tumor necrosis factor and interleukin 1β in glial cells. ( 22340390 )
2011
7
Memantine for AIDS dementia complex: open-label report of ACTG 301. ( 20400412 )
2010
8
Validity of the CogState brief battery: relationship to standardized tests and sensitivity to cognitive impairment in mild traumatic brain injury, schizophrenia, and AIDS dementia complex. ( 19395350 )
2009
9
High level HIV-1 DNA concentrations in brain tissues differentiate patients with post-HAART AIDS dementia complex or cardiovascular disease from those with AIDS. ( 19641870 )
2009
10
[Analysis of genetic diversity and biological functional site of HIV-1 gp120 from a patient with AIDS dementia complex]. ( 19634757 )
2009
11
Communication impairment in the AIDS dementia complex (ADC): a case report. ( 18242630 )
2008
12
Adjunctive therapies for AIDS dementia complex. ( 18646159 )
2008
13
Prevalence of AIDS dementia complex: results from a statewide population-based registry of Alzheimer's disease and related disorders. ( 19058735 )
2008
14
AIDS dementia complex in China. ( 17070055 )
2007
15
Factors in AIDS dementia complex trial design: results and lessons from the abacavir trial. ( 17401456 )
2007
16
Elevated cerebrospinal fluid neurofilament light protein concentrations predict the development of AIDS dementia complex. ( 17492593 )
2007
17
SV40 and HIV sequences in the cerebrospinal fluid of a patient with AIDS dementia complex. ( 17504176 )
2007
18
Proton MRS and neuropsychological correlates in AIDS dementia complex: evidence of subcortical specificity. ( 17827413 )
2007
19
AIDS dementia complex and Hashimoto encephalopathy in a senescent woman. ( 18033678 )
2007
20
AIDS dementia complex. ( 18808977 )
2007
21
Cerebrospinal fluid markers in central nervous system HIV infection and AIDS dementia complex. ( 18808988 )
2007
22
The assessment of cognitive function in advanced HIV-1 infection and AIDS dementia complex using a new computerised cognitive test battery. ( 16343841 )
2006
23
Timed Gait test: normative data for the assessment of the AIDS dementia complex. ( 16840235 )
2006
24
AIDS dementia complex. ( 16909695 )
2006
25
Editorial comment: AIDS dementia complex in the current era. ( 17152650 )
2006
26
Involvement of quinolinic acid in AIDS dementia complex. ( 15639803 )
2005
27
HAART & the molecular biology of AIDS dementia complex. ( 15817943 )
2005
28
Undetectable cerebrospinal fluid HIV RNA and beta-2 microglobulin do not indicate inactive AIDS dementia complex in highly active antiretroviral therapy-treated patients. ( 16010165 )
2005
29
Quinolinic acid selectively induces apoptosis of human astrocytes: potential role in AIDS dementia complex. ( 16042813 )
2005
30
Inflammation and neuroaxonal injury in multiple sclerosis and AIDS dementia complex: implications for neuroprotective treatment. ( 16138246 )
2005
31
The AIDS dementia complex: clinical and basic neuroscience with implications for novel molecular therapies. ( 16260383 )
2005
32
CSF amyloid beta42 and tau levels correlate with AIDS dementia complex. ( 16275845 )
2005
33
Olfactory deficits in HIV-infected patients with and without AIDS dementia complex. ( 14984801 )
2004
34
Evidence for a change in AIDS dementia complex in the era of highly active antiretroviral therapy and the possibility of new forms of AIDS dementia complex. ( 15075501 )
2004
35
The urokinase receptor is overexpressed in the AIDS dementia complex and other neurological manifestations. ( 15122709 )
2004
36
Chemokine receptors, neural progenitor cells, and the AIDS dementia complex. ( 15216453 )
2004
37
Regional patterns of brain metabolites in AIDS dementia complex. ( 15528093 )
2004
38
Cytokines and AIDS dementia complex. ( 12478083 )
2003
39
A multi-center 1H MRS study of the AIDS dementia complex: validation and preliminary analysis. ( 12766890 )
2003
40
Marked improvement in survival following AIDS dementia complex in the era of highly active antiretroviral therapy. ( 12824792 )
2003
41
SDF-1alpha is expressed in astrocytes and neurons in the AIDS dementia complex: an in vivo and in vitro study. ( 12834106 )
2003
42
Screening for the AIDS dementia complex. ( 11862659 )
2002
43
Clinical aspects of the AIDS dementia complex in relation to histopathological and immunohistochemical variables. ( 11914551 )
2002
44
Involvement of dopamine in the progression of AIDS Dementia Complex. ( 11956960 )
2002
45
Varied tropism of HIV-1 isolates derived from different regions of adult brain cortex discriminate between patients with and without AIDS dementia complex (ADC): evidence for neurotropic HIV variants. ( 11162807 )
2001
46
Elevated levels of soluble Fas and Fas ligand in cerebrospinal fluid of patients with AIDS dementia complex. ( 11240032 )
2001
47
Transforming growth factor beta-1 and interferon-alpha in the AIDS dementia complex (ADC): possible relationship with cerebral viral load? ( 11282546 )
2001
48
HIV-1 reverse transcriptase sequence in plasma and cerebrospinal fluid of patients with AIDS dementia complex treated with Abacavir. ( 11371689 )
2001
49
An overview of AIDS dementia complex. ( 11501344 )
2001
50
Cerebrospinal fluid S-100beta and its relationship with AIDS dementia complex. ( 11564589 )
2001

Variations for Aids Dementia Complex

Expression for Aids Dementia Complex

Search GEO for disease gene expression data for Aids Dementia Complex.

Pathways for Aids Dementia Complex

Pathways related to Aids Dementia Complex according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.96 CCR3 CXCL12 CXCR4 TNF
2
Show member pathways
12.8 CCR3 CXCL12 CXCR4 TNF
3
Show member pathways
12.5 CCR3 CXCL12 CXCR4
4
Show member pathways
12.36 B2M CXCL12 CXCR4 TNF
5
Show member pathways
11.83 CCR3 CXCL12 CXCR4
6
Show member pathways
11.82 B2M CCR3 CXCL12 CXCR4 TNF
7 11.77 B2M CXCL12 CXCR4 TNF
8 11.56 CXCL12 TNF
9 11.5 CXCL12 TNF
10 11.4 CXCL12 CXCR4
11
Show member pathways
11.4 CCR3 CXCL12 CXCR4
12 11.31 CXCL12 CXCR4
13 11.28 CCR3 TNF
14
Show member pathways
11.24 B2M TNF
15 11.09 CXCL12 CXCR4
16 10.86 CXCL12 CXCR4
17 10.21 CXCL12 TNF

GO Terms for Aids Dementia Complex

Cellular components related to Aids Dementia Complex according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.43 B2M CCR3 CXCL12 CXCR4 ITIH4 TNF
2 cell surface GO:0009986 9.33 B2M CXCR4 TNF
3 external side of plasma membrane GO:0009897 9.02 B2M CCR3 CXCL12 CXCR4 TNF

Biological processes related to Aids Dementia Complex according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.58 CCR3 CXCL12 CXCR4
2 inflammatory response GO:0006954 9.54 CCR3 CXCR4 TNF
3 calcium-mediated signaling GO:0019722 9.48 CCR3 CXCR4
4 chemokine-mediated signaling pathway GO:0070098 9.46 CCR3 CXCL12
5 positive regulation of endothelial cell proliferation GO:0001938 9.43 CCR3 CXCL12
6 chemotaxis GO:0006935 9.43 CCR3 CXCL12 CXCR4
7 response to virus GO:0009615 9.33 CXCL12 CXCR4 TNF
8 positive regulation of cell adhesion GO:0045785 9.32 CXCL12 TNF
9 cell chemotaxis GO:0060326 9.13 CCR3 CXCL12 CXCR4
10 immune response GO:0006955 9.02 B2M CCR3 CXCL12 CXCR4 TNF

Molecular functions related to Aids Dementia Complex according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine binding GO:0019956 9.26 CCR3 CXCR4
2 C-C chemokine binding GO:0019957 9.16 CCR3 CXCR4
3 C-C chemokine receptor activity GO:0016493 8.96 CCR3 CXCR4
4 chemokine receptor activity GO:0004950 8.62 CCR3 CXCR4

Sources for Aids Dementia Complex

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....