MCID: AKN002
MIFTS: 32

Akinetic Mutism

Categories: Neuronal diseases

Aliases & Classifications for Akinetic Mutism

MalaCards integrated aliases for Akinetic Mutism:

Name: Akinetic Mutism 12 55 44 15 17 72
Coma Vigilans 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4267
MeSH 44 D000405
SNOMED-CT 68 5124002 53333005
UMLS 72 C0001889

Summaries for Akinetic Mutism

Disease Ontology : 12 A brain disease characterized by marked reduction of nearly all motor functions including facial expressions, gestures and speech output, but with some degree of alertness.

MalaCards based summary : Akinetic Mutism, also known as coma vigilans, is related to creutzfeldt-jakob disease and toxic encephalopathy. An important gene associated with Akinetic Mutism is SLC6A3 (Solute Carrier Family 6 Member 3). The drugs Tacrolimus and carbamide peroxide have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and liver, and related phenotypes are nervous system and taste/olfaction

Wikipedia : 75 Akinetic mutism is a medical term describing patients tending neither to move (akinesia) nor speak... more...

Related Diseases for Akinetic Mutism

Diseases related to Akinetic Mutism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Related Disease Score Top Affiliating Genes
1 creutzfeldt-jakob disease 30.2 PRNP ENO2
2 toxic encephalopathy 30.1 SLC6A3 PRNP
3 prion disease 30.0 PRNP ENO2
4 mutism 11.2
5 hydrocephalus 10.7
6 congenital hydrocephalus 10.7
7 obstructive hydrocephalus 10.6
8 ocular motor apraxia 10.5
9 locked-in syndrome 10.4
10 cerebral artery occlusion 10.4
11 encephalopathy 10.4
12 hydrocephalus due to congenital stenosis of aqueduct of sylvius 10.3
13 anterior cerebral artery infarction 10.3
14 subacute delirium 10.3
15 brain injury 10.3
16 thrombophilia due to thrombin defect 10.2
17 stroke, ischemic 10.2
18 meningioma, radiation-induced 10.2
19 meningioma, familial 10.2
20 aphasia 10.2
21 thrombosis 10.2
22 spinal meningioma 10.2
23 nominal aphasia 10.2
24 secretory meningioma 10.2
25 lymphoplasmacyte-rich meningioma 10.2
26 cerebrovascular disease 10.2
27 traumatic brain injury 10.2
28 multiple sclerosis 10.1
29 systemic lupus erythematosus 10.1
30 schizophrenia 10.1
31 hydrocephalus, congenital, 1 10.1
32 hydrocephalus, normal-pressure 10.1
33 papilloma of choroid plexus 10.1
34 wilson disease 10.1
35 supranuclear palsy, progressive, 1 10.1
36 premature ovarian failure 7 10.1
37 immunodeficiency, common variable, 10 10.1
38 speech and communication disorders 10.1
39 apraxia 10.1
40 agraphia 10.1
41 cysticercosis 10.1
42 asthenopia 10.1
43 lymphocytic leukemia 10.1
44 amnestic disorder 10.1
45 intracranial aneurysm 10.1
46 hemiplegia 10.1
47 pica disease 10.1
48 aseptic meningitis 10.1
49 pseudobulbar palsy 10.1
50 quadriplegia 10.1

Graphical network of the top 20 diseases related to Akinetic Mutism:



Diseases related to Akinetic Mutism

Symptoms & Phenotypes for Akinetic Mutism

MGI Mouse Phenotypes related to Akinetic Mutism:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.35 CTSF DNAAF1 ENO2 PRNP SLC6A3
2 taste/olfaction MP:0005394 8.62 ENO2 SLC6A3

Drugs & Therapeutics for Akinetic Mutism

Drugs for Akinetic Mutism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tacrolimus Approved, Investigational 104987-11-3 445643 439492 6473866
2
carbamide peroxide Approved 124-43-6
3
Aspartic acid Approved, Nutraceutical 56-84-8 5960
4
Calcium Approved, Nutraceutical 7440-70-2 271
5 Immunologic Factors
6 Immunosuppressive Agents
7 Liver Extracts
8 Calcineurin Inhibitors
9 Hematinics
10 N-Methylaspartate
11 alanine
12 Anesthetics
13 Calcium, Dietary
14
Bilirubin 635-65-4, 69853-43-6 5280352 21252250

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Vagus Nerve Stimulation in Patients With Chronic Consciousness Disorders Recruiting NCT02591069
2 Perioperative Optic Nerve Sheath Diameter As A Predictor Of Early Tacrolimus Neurotoxicity In Living Donor Liver Transplantation Recruiting NCT03799770
3 Evaluation of Preoperative and Postoperative S100β and Neuron Specific Enolase Levels in Patients Undergoing Liver Transplantation Recruiting NCT03453047

Search NIH Clinical Center for Akinetic Mutism

Cochrane evidence based reviews: akinetic mutism

Genetic Tests for Akinetic Mutism

Anatomical Context for Akinetic Mutism

MalaCards organs/tissues related to Akinetic Mutism:

41
Brain, Eye, Liver, Thalamus, Cortex, Pons, Lung

Publications for Akinetic Mutism

Articles related to Akinetic Mutism:

(show top 50) (show all 481)
# Title Authors PMID Year
1
Leukoencephalopathy induced by tegafur: serial studies of somatosensory evoked potentials and cerebrospinal fluid. 9 38
1382734 1992
2
Why do neurologists miss catatonia in neurology emergency? A case series and brief literature review. 38
31147176 2019
3
Autopsied case of sporadic Creutzfeldt-Jakob disease classified as MM1+2C-type. 38
31062411 2019
4
Rapidly progressive miliary brain metastasis of lung cancer after EGFR tyrosine kinase inhibitor discontinuation: An autopsy report. 38
30868686 2019
5
Rare histotype of sporadic Creutzfeldt-Jakob disease, clinically suspected as corticobasal degeneration. 38
30850568 2019
6
An autopsied case of MM1-type sporadic Creutzfeldt-Jakob disease with pathology of Wernicke encephalopathy. 38
30409087 2019
7
Autopsy case of V180I genetic Creutzfeldt-Jakob disease presenting with early disease pathology. 38
30216556 2018
8
Evaluating the causality of novel sequence variants in the prion protein gene by example. 38
29861043 2018
9
Lesion network localization of free will. 38
30275309 2018
10
The Electroencephalogram Speaks for the Patient: Identification and Treatment of Akinetic Mutism With Comorbid Delirium. 38
29249557 2018
11
Atypical presentation of probable Creutzfeldt-Jakob disease associated with anti-Zic4 antibody: Literature review of neuronal antibodies in Creutzfeldt-Jakob disease. 38
29525731 2018
12
Epilepsia Partialis Continua as the First Presenting Symptom in Probable Sporadic Creutzfeldt-Jacob Disease: A Case Report and Literature Review. 38
30140219 2018
13
Akinetic mutism and the story of David. 38
28150524 2018
14
A Chinese patient of P102L Gerstmann-Sträussler-Scheinker disease contains three other disease-associated mutations in SYNE1. 38
29509064 2018
15
Akinetic mutism following prefrontal injury by an electrical grinder a case report: A diffusion tensor tractography study. 38
29419694 2018
16
Neurologic Complications of Transplantation. 38
28251577 2018
17
The language disorder of prion disease is characteristic of a dynamic aphasia and is rarely an isolated clinical feature. 38
29304167 2018
18
Predictive Factors for Early Initiation of Artificial Feeding in Patients With Sporadic Creutzfeldt-Jakob Disease. 38
30018588 2018
19
An Evaluation of Rapidly Progressive Dementia Culminating in a Diagnosis of Creutzfeldt-Jakob Disease. 38
30345127 2018
20
An autopsy case of Creutzfeldt-Jakob disease with a prion protein gene codon 180 mutation presenting with pathological laughing and an exaggerated startle reaction. 38
28703419 2017
21
Recovery of akinetic mutism and injured prefronto-caudate tract following shunt operation for hydrocephalus and rehabilitation: A case report. 38
29390310 2017
22
Clinical findings of a probable case of MM2-cortical-type sporadic Creutzfeldt-Jakob disease with antibodies to anti-N-terminus of α-enolase. 38
28967811 2017
23
MM1-type sporadic Creutzfeldt-Jakob disease with 1-month total disease duration and early pathologic indicators. 38
28402042 2017
24
Three sporadic cases of Creutzfeldt-Jakob disease in China and their clinical analysis. 38
28962210 2017
25
Successful combination immunotherapy of anti-gamma aminobutyric acid (GABA)A receptor antibody-positive encephalitis with extensive multifocal brain lesions. 38
28740064 2017
26
Serotonin Syndrome Following Combined Administration of Dopaminergic and Noradrenergic Agents in a Patient With Akinetic Mutism After Frontal Intracerebral Hemorrhage: A Case Report. 38
28622210 2017
27
A method for safely resecting anterior butterfly gliomas: the surgical anatomy of the default mode network and the relevance of its preservation. 38
27636183 2017
28
A Case Report of Probable Sporadic Creutzfeldt-Jakob Disease: How to Approach Early Diagnosis? 38
28680785 2017
29
Gastrostomy in patients with prion disease. 38
28509623 2017
30
Creutzfeldt-Jakob disease. 38
28028861 2017
31
Akinetic mutism revealing an ischemic stroke. 38
27955795 2017
32
Akinetic mutism reversibility after L-dopa therapy in unilateral left anterior cerebral artery infarction. 38
28447507 2017
33
Isolated language impairment as the primary presentation of sporadic Creutzfeldt Jakob Disease. 38
27072062 2017
34
[Patient with Creutzfeld-Jakob disease - a case report]. 38
28258683 2017
35
An autopsied case of MM1 + MM2-cortical with thalamic-type sporadic Creutzfeldt-Jakob disease presenting with hyperintensities on diffusion-weighted MRI before clinical onset. 38
27436355 2017
36
Akinetic mutism in a patient with acute infarcts in the bilateral substantia nigra. 38
28131224 2017
37
Akinetic mutism in a patient with mild traumatic brain injury: A diffusion tensor tractography study. 38
28406325 2017
38
Recovery of an injured prefronto-caudate tract in a patient with traumatic brain injury: A diffusion tensor tractography study. 38
28956643 2017
39
[Bromocriptine: could it be the cure for post-surgical akinetic mutism?] 38
28075000 2017
40
MRI and clinical manifestations of delayed encephalopathy after carbon monoxide poisoning. 38
28167472 2016
41
An autopsy-verified case of FTLD-TDP type A with upper motor neuron-predominant motor neuron disease mimicking MM2-thalamic-type sporadic Creutzfeldt-Jakob disease. 38
27929803 2016
42
Sporadic Creutzfeldt-Jakob disease with unusual initial presentation as posterior reversible encephalopathy syndrome: a case report. 38
27876002 2016
43
Mutated CTSF in adult-onset neuronal ceroid lipofuscinosis and FTD. 38
27668283 2016
44
Minimally Conscious State: Evolution of Concept, Diagnosis and Treatment. 38
27829654 2016
45
Specific clinical signs and symptoms are predictive of clinical course in sporadic Creutzfeldt-Jakob disease. 38
27222346 2016
46
Magnetic resonance-guided laser interstitial thermal therapy: report of a series of pediatric brain tumors. 38
26849811 2016
47
An autopsied case of unclassifiable sporadic four-repeat tauopathy presenting with parkinsonism and speech disturbances. 38
26610886 2016
48
Reversible Changes of Brain Perfusion SPECT for Carbon Monoxide Poisoning-Induced Severe Akinetic Mutism. 38
26825206 2016
49
Non-invasive brain stimulation to promote alertness and awareness in chronic patients with disorders of consciousness: Low-level, near-infrared laser stimulation vs. focused shock wave therapy. 38
27080072 2016
50
Creutzfeldt-Jakob Disease Presenting With Dizziness and Gaze-Evoked Nystagmus: A Case Report. 38
26886621 2016

Variations for Akinetic Mutism

Expression for Akinetic Mutism

Search GEO for disease gene expression data for Akinetic Mutism.

Pathways for Akinetic Mutism

GO Terms for Akinetic Mutism

Molecular functions related to Akinetic Mutism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 8.62 SLC6A3 PRNP

Sources for Akinetic Mutism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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