MCID: AKN002
MIFTS: 33

Akinetic Mutism

Categories: Neuronal diseases

Aliases & Classifications for Akinetic Mutism

MalaCards integrated aliases for Akinetic Mutism:

Name: Akinetic Mutism 12 55 44 15 73
Coma Vigilans 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4267
MeSH 44 D000405
SNOMED-CT 68 5124002 53333005
UMLS 73 C0001889

Summaries for Akinetic Mutism

Disease Ontology : 12 A brain disease characterized by marked reduction of nearly all motor functions including facial expressions, gestures and speech output, but with some degree of alertness.

MalaCards based summary : Akinetic Mutism, also known as coma vigilans, is related to brain injury and aphasia. An important gene associated with Akinetic Mutism is SLC6A3 (Solute Carrier Family 6 Member 3), and among its related pathways/superpathways are Neuroscience and Copper homeostasis. Affiliated tissues include brain, eye and thyroid, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : 76 Akinetic mutism is a medical term describing patients tending neither to move (akinesia) nor speak... more...

Related Diseases for Akinetic Mutism

Diseases related to Akinetic Mutism via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
# Related Disease Score Top Affiliating Genes
1 brain injury 30.3 ENO2 MAPT
2 aphasia 30.0 MAPT PRNP
3 supranuclear palsy, progressive, 1 29.9 MAPT SLC6A3
4 hydrocephalus 29.9 ENO2 MAPT
5 creutzfeldt-jakob disease 29.6 ENO2 MAPT PRNP
6 dementia 29.4 MAPT PRNP SLC6A3
7 mutism 11.0
8 cerebritis 10.5
9 obstructive hydrocephalus 10.3
10 cerebral artery occlusion 10.2
11 anterior cerebral artery infarction 10.2
12 leukoencephalopathy, hereditary diffuse, with spheroids 10.1 MAPT PRNP
13 toxic encephalopathy 10.1 PRNP SLC6A3
14 agraphia 10.1 MAPT PRNP
15 traumatic brain injury 10.1
16 cerebral amyloid angiopathy, cst3-related 10.1 MAPT PRNP
17 multiple system atrophy 1 10.1 MAPT SLC6A3
18 scrapie 10.1 ENO2 PRNP
19 movement disease 10.0 MAPT SLC6A3
20 multiple sclerosis 9.9
21 schizophrenia 9.9
22 lung cancer 9.9
23 papilloma of choroid plexus 9.9
24 wilson disease 9.9
25 choroiditis 9.9
26 locked-in syndrome 9.9
27 basilar artery occlusion 9.9
28 cervicitis 9.9
29 papilloma 9.9
30 astrocytoma 9.9
31 craniopharyngioma 9.9
32 hemangioblastoma 9.9
33 progressive multifocal leukoencephalopathy 9.9
34 thyroiditis 9.9
35 intestinal obstruction 9.9
36 glioma 9.9
37 aneurysm 9.9
38 anoxia 9.9
39 classic progressive supranuclear palsy syndrome 9.9
40 serotonin syndrome 9.9
41 synucleinopathy 9.9 MAPT SLC6A3
42 disease of mental health 9.8 MAPT SLC6A3
43 dementia, lewy body 9.7 MAPT PRNP SLC6A3
44 central nervous system disease 9.7 MAPT PRNP SLC6A3
45 nervous system disease 9.7 MAPT PRNP SLC6A3
46 prion disease 9.6 ENO2 MAPT PRNP
47 frontotemporal dementia 9.4 MAPT PRNP

Graphical network of the top 20 diseases related to Akinetic Mutism:



Diseases related to Akinetic Mutism

Symptoms & Phenotypes for Akinetic Mutism

MGI Mouse Phenotypes related to Akinetic Mutism:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.65 ENO2 MAPT PRNP SLC6A3 CTSF
2 growth/size/body region MP:0005378 9.55 CTSF ENO2 MAPT PRNP SLC6A3
3 nervous system MP:0003631 9.35 CTSF ENO2 MAPT PRNP SLC6A3
4 taste/olfaction MP:0005394 8.8 ENO2 MAPT SLC6A3

Drugs & Therapeutics for Akinetic Mutism

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Vagal Nerve Stimulation in Coma Patients Recruiting NCT02591069 Not Applicable

Search NIH Clinical Center for Akinetic Mutism

Cochrane evidence based reviews: akinetic mutism

Genetic Tests for Akinetic Mutism

Anatomical Context for Akinetic Mutism

MalaCards organs/tissues related to Akinetic Mutism:

41
Brain, Eye, Thyroid, Lung, Bone Marrow, Bone, Liver

Publications for Akinetic Mutism

Articles related to Akinetic Mutism:

(show top 50) (show all 113)
# Title Authors Year
1
Akinetic mutism following prefrontal injury by an electrical grinder a case report: A diffusion tensor tractography study. ( 29419694 )
2018
2
The Electroencephalogram Speaks for the Patient: Identification and Treatment of Akinetic Mutism With Comorbid Delirium. ( 29249557 )
2017
3
Akinetic mutism in a patient with acute infarcts in the bilateral substantia nigra. ( 28131224 )
2017
4
Recovery of akinetic mutism and injured prefronto-caudate tract following shunt operation for hydrocephalus and rehabilitation: A case report. ( 29390310 )
2017
5
Akinetic mutism and the story of David. ( 28150524 )
2017
6
Akinetic mutism in a patient with mild traumatic brain injury: A diffusion tensor tractography study. ( 28406325 )
2017
7
Akinetic mutism reversibility after L-dopa therapy in unilateral left anterior cerebral artery infarction. ( 28447507 )
2017
8
Serotonin Syndrome Following Combined Administration of Dopaminergic and Noradrenergic Agents in a Patient With Akinetic Mutism After Frontal Intracerebral Hemorrhage: A Case Report. ( 28622210 )
2017
9
Reversible Changes of Brain Perfusion SPECT for Carbon Monoxide Poisoning-Induced Severe Akinetic Mutism. ( 26825206 )
2016
10
Reversible Akinetic Mutism after Aneurysmal Subarachnoid Haemorrhage in the Territory of the Anterior Cerebral Artery without Permanent Ischaemic Damage to Anterior Cingulate Gyri. ( 27418987 )
2016
11
Akinetic mutism revealing an ischemic stroke. ( 27955795 )
2016
12
Unique presentation of akinetic mutism and coexisting thyroid storm relating to stroke. ( 25530892 )
2014
13
Akinetic mutism without a structural prefrontal lesion. ( 23812168 )
2013
14
Telephone effect in akinetic mutism from traumatic brain injury. ( 23932533 )
2013
15
Akinetic mutism-a serious complication to tacrolimus-based GVHD prophylaxis. ( 22705799 )
2013
16
Akinetic mutism and utilization behavior after bilateral thalamo-polar artery stroke. ( 23775322 )
2013
17
Delayed post-hypoxic leucoencephalopathy presenting akinetic mutism after traumatic cervical cord injury: a case report. ( 23472625 )
2013
18
Akinetic Mutism and Parkinsonism due to Subdural and Intraventricular Tension Pneumocephalus. ( 23322598 )
2013
19
Rapid resolution of akinetic mutism in delayed post-hypoxic leukoencephalopathy with intravenous magnesium sulfate. ( 22672948 )
2012
20
Akinetic mutism caused by HIV-associated progressive multifocal leukoencephalopathy was successfully treated with mefloquine: a serial multimodal MRI Study. ( 22246492 )
2012
21
Akinetic mutism and parkinsonism after multiple shunt failure: case report and literature review. ( 21445822 )
2012
22
Leukoencephalopathy and akinetic mutism in a married couple: a probable association with oriental medicine. ( 22259619 )
2011
23
Survival to akinetic mutism state in Japanese cases of MM1-type sporadic Creutzfeldt-Jakob disease is similar to Caucasians. ( 20722706 )
2011
24
Vegetative state, minimally conscious state, akinetic mutism and Parkinsonism as a continuum of recovery from disorders of consciousness: an exploratory and preliminary study. ( 21693084 )
2011
25
Treatment of chronic akinetic mutism with atomoxetine: subtraction analysis of brain f-18 fluorodeoxyglucose positron emission tomographic images before and after medication: a case report. ( 20661027 )
2010
26
Akinetic mutism induced by tacrolimus. ( 19820432 )
2009
27
Akinetic mutism--not coma. ( 19297375 )
2009
28
Persistent akinetic mutism after bilateral paramedian thalamic infarction. ( 19776325 )
2009
29
Treatment of akinetic mutism with intramuscular olanzapine: a case series. ( 18305290 )
2008
30
Akinetic mutism responsive to bromocriptine following subdural hematoma evacuation in a patient with hydrocephalus. ( 17895616 )
2007
31
Akinetic mutism after right internal watershed infarction. ( 17453106 )
2007
32
Akinetic mutism caused by nicotine withdrawal. ( 19455735 )
2007
33
Diminution of basal ganglia dopaminergic function may play an important role in the generation of akinetic mutism in a patient with anterior cerebral arterial infarct. ( 17543443 )
2007
34
Akinetic Mutism and Cognitive-Affective Syndrome Caused by Unilateral PICA Infarction. ( 19513131 )
2007
35
Akinetic mutism followed by a manic reaction on introduction of steroid replacement for Addison's disease. ( 16682841 )
2006
36
[MM1 variant of sporadic Creutzfeldt-Jakob disease with long duration akinetic mutism state]. ( 17013791 )
2006
37
Akinetic mutism following stroke. ( 14642361 )
2004
38
Frontal lobe and cingulate cortical metabolic dysfunction in acquired akinetic mutism: a PET study of the interval form of carbon monoxide poisoning. ( 15204341 )
2004
39
Subarachnoid haemorrhage and akinetic mutism. ( 15327227 )
2004
40
Preserved auditory cognitive ERPs in severe akinetic mutism: a case report. ( 15019716 )
2004
41
Event-related brain potentials in a patient with akinetic mutism. ( 12711129 )
2003
42
Akinetic mutism following unilateral anterior cerebral artery occlusion. ( 12928521 )
2003
43
OKT3 neurotoxicity presenting as akinetic mutism. ( 12698102 )
2003
44
Bromocriptine-responsive akinetic mutism following endoscopy for ventricular neurocysticercosis. Case report and review of the literature. ( 12924716 )
2003
45
Clinicopathologic case report: akinetic mutism with findings of white matter hyperintensity. ( 11983799 )
2002
46
Akinetic mutism caused by bilateral infiltration of the fornix in a patient with astrocytoma. ( 11985642 )
2002
47
BIPLEDs in akinetic mutism caused by bilateral anterior cerebral artery infarction. ( 11514256 )
2001
48
Chronic akinetic mutism after mesencephalic-diencephalic infarction: remediated with dopaminergic medications. ( 11811256 )
2001
49
[Akinetic mutism and progressive supranuclear palsy-like syndrome after the shunt of an obstructive hydrocephalus. Successful treatment with bromocriptine: 2 cases]. ( 10795015 )
2000
50
Akinetic mutism from frontal lobe damage responding to levodopa. ( 10993505 )
2000

Variations for Akinetic Mutism

Expression for Akinetic Mutism

Search GEO for disease gene expression data for Akinetic Mutism.

Pathways for Akinetic Mutism

Pathways related to Akinetic Mutism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.33 ENO2 MAPT PRNP
2 10.69 MAPT PRNP

GO Terms for Akinetic Mutism

Cellular components related to Akinetic Mutism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuronal cell body GO:0043025 8.8 ENO2 MAPT SLC6A3

Biological processes related to Akinetic Mutism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of neuron death GO:1901216 8.62 MAPT PRNP

Molecular functions related to Akinetic Mutism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chaperone binding GO:0051087 9.16 MAPT PRNP
2 tubulin binding GO:0015631 8.96 MAPT PRNP
3 protein phosphatase 2A binding GO:0051721 8.62 MAPT SLC6A3

Sources for Akinetic Mutism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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