MCID: ALC007
MIFTS: 65

Alcohol Dependence

Categories: Cancer diseases, Genetic diseases, Mental diseases
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Aliases & Classifications for Alcohol Dependence

MalaCards integrated aliases for Alcohol Dependence:

Name: Alcohol Dependence 57 11 75 28 5 14 38 33
Alcoholism 57 11 53 14 33
Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against 57 5
Alcohol Dependence, Protection Against 57 12
Alcohol Dependence, Susceptibility to 57 5
Alcoholic Intoxication, Chronic 71
Alcoholism, Susceptibility to 5
Chronic Alcoholic Disease Nos 33
Alcoholic Disease Nos 33
Pharyngeal Neoplasms 71
Chronic Alcoholism 33
Ethanol Dependence 33
Chronic Ethanolism 33
Alcohol Addiction 33
Dipsomania 33
Alcoholic 33

Characteristics:


Inheritance:

Probably multifactorial genetically influenced 57

Classifications:



External Ids:

Disease Ontology 11 DOID:0050741
OMIM® 57 103780
SNOMED-CT 68 66590003
MedGen 40 C0001973
UMLS 71 C0001973 C0031347

Summaries for Alcohol Dependence

Disease Ontology: 11 A substance dependence that is characterized by tolerance, withdrawal symptoms, increasing use, persistent desire to decrease consumption, time spent obtaining or recovering from alcohol caused by a physical and psychological dependence on alcohol.

MalaCards based summary: Alcohol Dependence, also known as alcoholism, is related to alcohol use disorder and personality disorder. An important gene associated with Alcohol Dependence is GABRA2 (Gamma-Aminobutyric Acid Type A Receptor Subunit Alpha2), and among its related pathways/superpathways are Transmission across Chemical Synapses and Metapathway biotransformation Phase I and II. The drugs Diazepam and Ledipasvir have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and prefrontal cortex, and related phenotypes are alcoholism and nervous system

Wikipedia: 75 Alcohol dependence is a previous (DSM-IV and ICD-10) psychiatric diagnosis in which an individual is... more...

More information from OMIM: 103780

Related Diseases for Alcohol Dependence

Diseases related to Alcohol Dependence via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1638)
# Related Disease Score Top Affiliating Genes
1 alcohol use disorder 33.9 SLC6A4 SLC6A3 OPRM1 MAOA GABRA2 DRD2
2 personality disorder 32.3 SLC6A4 SLC6A3 NRXN3 MAOA HTR2A DRD2
3 substance dependence 32.3 SLC6A4 SLC6A3 OPRM1 OPRK1 MAOA HTR2A
4 substance abuse 32.2 SLC6A4 SLC6A3 OPRM1 OPRK1 MAOA HTR2A
5 anxiety 32.2 SLC6A4 SLC6A3 OPRM1 OPRK1 MAOA HTR2A
6 drug dependence 32.1 SLC6A4 SLC6A3 OPRM1 OPRK1 MAOA GABRA2
7 post-traumatic stress disorder 32.1 SLC6A4 SLC6A3 MAOA HTR2A DRD2
8 major depressive disorder 32.1 SLC6A4 SLC6A3 OPRM1 MAOA HTR2A DRD2
9 tobacco addiction 32.1 TAS2R16 SLC6A4 SLC6A3 OPRM1 NRXN3 MAOA
10 bipolar disorder 32.0 SLC6A4 SLC6A3 OPRM1 MAOA HTR2A GABRA2
11 withdrawal disorder 32.0 SLC6A4 SLC6A3 OPRM1 OPRK1 DRD2
12 antisocial personality disorder 31.9 SLC6A4 SLC6A3 MAOA HTR2A GABRA2 DRD2
13 psychotic disorder 31.9 SLC6A4 SLC6A3 OPRM1 NRXN3 MAOA HTR2A
14 conduct disorder 31.9 SLC6A4 SLC6A3 MAOA GABRA2 DRD2 ALDH2
15 attention deficit-hyperactivity disorder 31.9 SLC6A4 SLC6A3 OPRM1 NRXN3 MAOA HTR2A
16 cocaine dependence 31.8 SLC6A4 SLC6A3 OPRM1 OPRK1 GABRA2 DRD2
17 mood disorder 31.8 SLC6A4 SLC6A3 MAOA HTR2A DRD2
18 opiate dependence 31.8 SLC6A4 SLC6A3 OPRM1 OPRK1 DRD2
19 social phobia 31.7 SLC6A4 SLC6A3 MAOA HTR2A DRD2
20 schizophrenia 31.7 SLC6A4 SLC6A3 OPRM1 NRXN3 MAOA HTR2A
21 panic disorder 31.6 SLC6A4 SLC6A3 MAOA HTR2A DRD2
22 pathological gambling 31.5 SLC6A4 SLC6A3 OPRM1 MAOA HTR2A DRD2
23 brunner syndrome 31.5 SLC6A4 MAOA HTR2A
24 liver cirrhosis 31.5 CYP2E1 ALDH2 ADH1C ADH1B
25 borderline personality disorder 31.5 SLC6A4 SLC6A3 NRXN3 MAOA HTR2A DRD2
26 generalized anxiety disorder 31.4 SLC6A4 MAOA HTR2A DRD2
27 sleep disorder 31.4 SLC6A4 SLC6A3 HTR2A
28 dysthymic disorder 31.4 SLC6A4 SLC6A3 MAOA HTR2A
29 agoraphobia 31.3 SLC6A4 MAOA HTR2A
30 acute stress disorder 31.3 SLC6A4 HTR2A
31 eating disorder 31.3 SLC6A4 SLC6A3 OPRM1 HTR2A DRD2
32 bulimia nervosa 31.3 SLC6A4 SLC6A3 MAOA HTR2A DRD2
33 obsessive-compulsive disorder 31.2 SLC6A4 SLC6A3 MAOA HTR2A DRD2
34 alcoholic cardiomyopathy 31.2 CYP2E1 ALDH2 ADH7 ADH1B
35 hepatic encephalopathy 31.2 OPRM1 MAOA DRD2
36 alcoholic liver cirrhosis 31.2 CYP2E1 ALDH9A1 ALDH2 ADH1C ADH1B
37 alexithymia 31.2 SLC6A4 HTR2A DRD2
38 cocaine abuse 31.2 SLC6A4 SLC6A3 OPRM1 OPRK1 HTR2A DRD2
39 oppositional defiant disorder 31.2 SLC6A4 SLC6A3 MAOA HTR2A GABRA2 DRD2
40 disease of mental health 31.1 SLC6A4 SLC6A3 OPRM1 MAOA HTR2A DRD2
41 alzheimer disease, familial, 1 31.1 SLC6A4 SLC6A3 OPRM1 MAOA HTR2A DRD2
42 endogenous depression 31.1 SLC6A4 SLC6A3 MAOA HTR2A DRD2
43 paranoid schizophrenia 31.1 SLC6A4 MAOA HTR2A DRD2
44 gilles de la tourette syndrome 31.1 SLC6A4 SLC6A3 NRXN3 MAOA HTR2A DRD2
45 bipolar i disorder 31.0 SLC6A4 HTR2A DRD2
46 heroin dependence 30.9 SLC6A4 SLC6A3 OPRM1 MAOA HTR2A DRD2
47 anorexia nervosa 30.9 SLC6A4 MAOA HTR2A DRD2
48 fetal alcohol syndrome 30.9 CYP2E1 ALDH2 ADH7 ADH4 ADH1C ADH1B
49 narcolepsy 30.9 SLC6A3 MAOA HTR2A DRD2
50 tic disorder 30.9 SLC6A4 SLC6A3 NRXN3 MAOA HTR2A DRD2

Graphical network of the top 20 diseases related to Alcohol Dependence:



Diseases related to Alcohol Dependence

Symptoms & Phenotypes for Alcohol Dependence

Human phenotypes related to Alcohol Dependence:

30
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 alcoholism 30 HP:0030955

Symptoms via clinical synopsis from OMIM®:

57 (Updated 08-Dec-2022)
Neuro:
alcoholism

Misc:
25 to 50% lifetime risk for sons and brothers of severely alcoholic men

Clinical features from OMIM®:

103780 (Updated 08-Dec-2022)

GenomeRNAi Phenotypes related to Alcohol Dependence according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.18 ADH1B ADH1C ADH4 ADH7 ALDH2 ALDH9A1
2 no effect GR00402-S-2 10.18 ADH1B ADH1C ADH4 ALDH2 CHRNA6 CYP2E1

MGI Mouse Phenotypes related to Alcohol Dependence:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.73 ADH7 ALDH2 CHRNA6 DRD2 GABRA2 LAMA2
2 behavior/neurological MP:0005386 9.4 ADH7 ALDH2 CYP2E1 DRD2 GABRA2 HTR2A

Drugs & Therapeutics for Alcohol Dependence

Drugs for Alcohol Dependence (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 656)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 4 439-14-5 3016
2
Ledipasvir Approved Phase 4 1256388-51-8 67505836
3
Sofosbuvir Approved Phase 4 1190307-88-0 45375808
4
Lenograstim Approved, Investigational Phase 4 135968-09-1
5
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 11128-99-7, 4474-91-3 172198
6
Alogliptin Approved Phase 4 850649-61-5 11450633
7
Entecavir Approved, Investigational Phase 4 142217-69-4 153941
8
Alprostadil Approved, Investigational Phase 4 745-65-3 5280723
9
Glycyrrhizic acid Approved, Experimental Phase 4 1405-86-3 3495 14982
10
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
11
Amlodipine Approved Phase 4 88150-42-9 2162
12
Perindopril Approved Phase 4 82834-16-0, 107133-36-8 107807
13
Ondansetron Approved, Withdrawn Phase 4 99614-02-5 4595
14
Nicotine Approved Phase 4 54-11-5 942 89594
15
Exenatide Approved, Investigational Phase 4 141758-74-9 45588096
16
Lorazepam Approved Phase 4 846-49-1 3958
17
Sodium oxybate Approved Phase 4 502-85-2 23663870
18
Oxazepam Approved Phase 4 604-75-1 4616
19
Baclofen Approved Phase 4 1134-47-0 2284
20
Varenicline Approved, Investigational Phase 4 249296-44-4 5310966
21
Memantine Approved, Investigational Phase 4 41100-52-1, 19982-08-2 4054
22
Levetiracetam Approved Phase 4 102767-28-2 441341 5284583
23
Citalopram Approved Phase 4 59729-32-7, 59729-33-8 2771
24
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
25
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
26
Ribavirin Approved Phase 4 36791-04-5 37542
27
Carbamazepine Approved, Investigational Phase 4 298-46-4 2554
28
Benzyl alcohol Approved Phase 4 100-51-6 244
29
Atomoxetine Approved Phase 4 82248-59-7, 83015-26-3 54841
30
Isoniazid Approved, Investigational Phase 4 54-85-3 3767
31
Chlorzoxazone Approved Phase 4 95-25-0 2733
32
Chlorhexidine Approved, Vet_approved, Withdrawn Phase 4 55-56-1 2713 9552079
33
Adenosine Approved, Investigational Phase 4 58-61-7 60961
34
Povidone-iodine Approved Phase 4 25655-41-8
35
Gliclazide Approved Phase 4 21187-98-4 3475
36
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
37
Ezetimibe Approved Phase 4 163222-33-1 150311
38
Montelukast Approved Phase 4 158966-92-8 5281040
39
Glimepiride Approved Phase 4 93479-97-1 3476
40
Insulin aspart Approved Phase 4 116094-23-6 16132418
41
Insulin detemir Approved Phase 4 169148-63-4 16137271
42
Phentermine Approved, Illicit Phase 4 122-09-8 4771
43
Rifampicin Approved Phase 4 13292-46-1 135512673 5381226 135900090
44
Orlistat Approved, Investigational Phase 4 96829-58-2 3034010
45
Racepinephrine Approved, Vet_approved Phase 4 51-43-4, 329-65-7 838 5816
46
Empagliflozin Approved Phase 4 864070-44-0 73151030 11949646
47
Dapagliflozin Approved Phase 4 461432-26-8 9887712
48
Acetylcysteine Approved, Investigational Phase 4 616-91-1 581 12035
49
Histamine Approved, Investigational Phase 4 51-45-6 774
50
Calcium carbonate Approved, Investigational Phase 4 471-34-1

Interventional clinical trials:

(show top 50) (show all 2647)
# Name Status NCT ID Phase Drugs
1 Safety of Acamprosate for Alcohol Dependence in the Elderly: An Open-Label Study Unknown status NCT00655967 Phase 4 Acamprosate (Campral);Acamprosate
2 The Role of Pharmacotherapy in Prevention of Relapse in Alcohol Dependence Unknown status NCT00120601 Phase 4 Naltrexone;Acamprosate
3 Topiramate for Hospitalized Patients With Alcoholism: a 12-Week Open-Label Study Unknown status NCT01135602 Phase 4 Topiramate
4 Prospective Assessment of Valproate on Ethanol Withdrawal Unknown status NCT03235531 Phase 4 Valproate;Lorazepam
5 Antabuse in Severe Alcoholism: an Open Controlled Study Unknown status NCT00431262 Phase 4 antabuse (disulfiram)
6 Phone-based Safety Monitoring of the First Year of Baclofen Treatment for Alcohol Use Disorder: the BACLOPHONE Cohort Study Unknown status NCT02596763 Phase 4 Baclofen
7 The Effect of N-acetylcysteine (NAC) on Treatment of Alcohol and Cocaine Use Disorders: A Double-Blind Randomized Controlled Trial. Unknown status NCT03018236 Phase 4 Alcohol N-acetylcysteine;Alcohol Placebo;Cocaine N-acetylcysteine;Cocaine Placebo
8 Baclofen Bij de Behandeling Van Acute Alcoholontwenning Unknown status NCT03293017 Phase 4 Diazepam 10 MG;Baclofen 30mg;Baclofen 60mg
9 Effect of Probiotics on Gut-Liver Axis of Alcoholic Hepatitis Unknown status NCT02335632 Phase 4 Probiotics (Lacidofil®);Placebo
10 A Phase IV, Single Arm, Open-Label Study to Determine the Efficacy and Safety of Ledipasvir/Sofosbuvir (LDV/SOF) in Treatment-Naive Alcoholic Subjects With Chronic Genotype 1 Hepatitis C Infection Unknown status NCT02759861 Phase 4 harvoni
11 Granulocyte Colony Stimulating Factor in Alcoholic Hepatitis Unknown status NCT03703674 Phase 4 GCSF
12 Effect of Metadoxine on Oxidative Stress in Non-alcoholic Fatty Liver Disease Prediabetic Mexican Patients Unknown status NCT02051842 Phase 4 Metadoxine
13 Granulocyte Colony Stimulating Factor Plus N-Acetyl Cysteine In Severe Alcoholic Hepatitis Unknown status NCT02971306 Phase 4 standard medical therapy;G-CSF;n-Acetylcysteine
14 A Randomised Controlled Trial of Lifestyle Versus Ezetimibe Plus Lifestyle in Patients With Non-alcoholic Steatohepatitis Unknown status NCT01950884 Phase 4 Ezetimibe
15 THE EFFECT OF DUAL TREATMENT WITH L-CARNITINE AND MAGNESIUM ON Patients With Non Alcoholic Fatty Liver Disease Unknown status NCT01956825 Phase 4
16 S.P.PRO LIVER POWDER is Used to Improve Liver and Metabolic Indexes in People With Non-alcoholic Fatty Liver Disease Unknown status NCT04718051 Phase 4 Shen Pu Yang Gan Wan;Placebo
17 Efficacy and Safety of S-adenosyl-l-methionine in Treatment of Alcoholic Hepatitis With Cholestasis Unknown status NCT02024295 Phase 4 Ademethionine;Polyene Phosphatidyl choline
18 Effectiveness of Pre-surgical Hand Washing in Reducing Bacterial Load, Using an Alcoholic Solution of Chlorhexidine Digluconate and Potassium Sorbate Unknown status NCT04683146 Phase 4 Hand antisepsis with Propanolol- 1 60%.;Hand antisepsis with a solution of alcohol, chlorhexidine digluconate and potassium sorbate.
19 Placebo Controlled Study Using Lovaza as Treatment for Non-Alcoholic Fatty Liver Disease Unknown status NCT00941642 Phase 4 Lovaza;placebo control
20 Comparison of The Effects of Thiazolidinediones(TZD), Sodium- Glucose Cotransporter 2 Inhibitors(SGLT2i) Alone and TZD / SGLT2i Combination Therapy on Non-alcoholic Fatty Liver Disease in Type 2 Diabetic Patients With Fatty Liver Unknown status NCT03646292 Phase 4 Pioglitazone;Empagliflozin;Combination of pioglitazone and empagliflozin
21 The Effect of Consecutive Fecal Microbiota Transplantation on Non-Alcoholic Fatty Liver Disease (NAFLD) - a Randomized-controlled Trial - Unknown status NCT04465032 Phase 4
22 Efficacy and Safety of Berberine in Non-alcoholic Steatohepatitis: a Multicentre, Randomised, Placebo-controlled Trial Unknown status NCT03198572 Phase 4 Placebo;Berberine
23 To Evaluate the Effect of Nesinaact on Non-alcoholic Steatohepatitis Through MRI and Liver Fibroscan in Patients With Type 2 Diabetes: A Prospective, Open-Label, Single-Arm, Single-Center Clinical Study Unknown status NCT03950505 Phase 4 Nesinaact 25/15 (Alogliptin benzoate 25mg, pioglitazone hydrochloride 15mg) treatment for 24 weeks
24 An Randomized Open Label Trial on the Impact of 24 Weeks of Atorvastatin Therapy on Liver Fat Content and Abdominal Fat Content in Patients With Type 2 Diabetes Combined With High LDL-C and Non-alcoholic Fatty Liver Disease Unknown status NCT01720719 Phase 4 atorvastatin;Vitamin E
25 Losartan in the Prevention of Sodium Retention and Ascites in Liver Cirrhosis - a Prospective Randomized Long-Term Study Unknown status NCT00239096 Phase 4 losartan (drug)
26 Granulocyte Colony-stimulating Factor(G-CSF) in the Treatment of Hepatic Failure: a Prospective Randomized Controlled Clinical Study Unknown status NCT02331745 Phase 4 Granulocyte colony-stimulating factor;standard treatment
27 The Effect of Empagliflozin on NAFLD in Asian Patients With Type 2 Diabetes Unknown status NCT02964715 Phase 4 Empagliflozin
28 Pilot Study to Assess the Antiviral Activity and Safety of Besifovir Dipivoxil 150mg and L-carnitine 660mg Compared to Tenofovir Alafenamide 25mg in Chronic Hepatitis B Patients With Nonalcoholic Fatty Liver Unknown status NCT03604016 Phase 4 Besifovir dipivoxil;L-carnitine;Tenofovir Alafenamide
29 Randomized Study Comparing Switching to Raltegravir-based Antiretroviral Versus Maintaining Any Other Antiretroviral Therapy in HIV Monoinfected Patients Impact on Fatty Liver and Liver Fibrosis Assessed by Noninvasive Diagnostic Methods Unknown status NCT02210715 Phase 4 Isentress.
30 Evaluation of Perindopril and Telmisartan for the Treatment of Nonalcoholic Fatty Liver Disease: A Randomized Controlled Trial Unknown status NCT02213224 Phase 4 Perindopril;Telmisartan;Amlodipine
31 Citicoline for Alcohol Dependence Completed NCT02074735 Phase 4 Placebo;Citicoline
32 Primary Care Based Disease Management for Alcohol Dependence Completed NCT00419315 Phase 4
33 Disulfiram Combined With Lorazepam for Treatment of Patients With Alcohol Dependence and Primary or Secondary Anxiety Disorder Completed NCT00721526 Phase 4 disulfiram plus lorazepam
34 The Gamma Hydroxybutyric Acid in Alcohol-dependence Treatment Efficacy (GATE) I Trial: a Comparative Study Versus Oxazepam in the Treatment of Alcohol Withdrawal Syndrome Completed NCT02090504 Phase 4 Sodium Oxybate (SMO);Oxazepam
35 Phase Four Randomized, Multicentre, Open-Label, Comparative Trial Of Disulfiram, Nalterexone And Acamprosate In The Treatment Of Alcohol Dependence Completed NCT00435435 Phase 4 Disulfiram;Acamprosate;Naltexone
36 Campral (Acamprosate) Treatment of Alcohol Dependence in a Family Medicine Setting: A Randomized, Double-Blind Placebo-Controlled Study Completed NCT00381043 Phase 4 Acamprosate (Campral)
37 Pharmacogenetic Response to Naltrexone for Alcohol Dependence Completed NCT00831272 Phase 4 naltrexone;Placebo
38 Quetiapine for Bipolar Disorder and Alcohol Dependence Completed NCT00457197 Phase 4 Placebo;Quetiapine
39 Injectable Versus Oral Naltrexone Treatment of Alcohol Dependence In Serious Mental Illness (SMI): A Pilot Study Completed NCT00453804 Phase 4 injectable naltrexone;oral naltrexone
40 Injectable Naltrexone Treatment of Alcohol Dependence in Serious Mental Illness (SMI): An Open Prospective Pilot Trial Completed NCT00453609 Phase 4 long-lasting injectable naltrexone
41 Naltrexone for Bipolar Disorder and Alcohol Dependence Completed NCT00223275 Phase 4 Naltrexone
42 12 Week Prospective Double Blind Placebo Controlled Randomized Trial of Seroquel SR for Alcohol Dependence and Comorbid Anxiety Completed NCT00352469 Phase 4 Seroquel XR
43 The Use of Acamprosate in Individuals With Alcohol Dependence and Comorbid Anxiety or Depression Completed NCT00330174 Phase 4 Acamprosate
44 Extended-release Naltrexone (Vivitrol) for the Treatment of Alcohol Dependence in Urban Primary Care: a Feasibility Study Completed NCT00620750 Phase 4 Extended release injectable naltrexone (Vivitrol)
45 Zonisamide vs. Placebo in the Treatment of Alcohol Dependence Completed NCT00595556 Phase 4 zonisamide;Placebo
46 A Double-Blind Placebo-Controlled Trial of Prazosin for the Treatment of Alcohol Dependence Completed NCT00167687 Phase 4 prazosin
47 Etiology and Treatment of Alcohol Dependence Completed NCT00000442 Phase 4 naltrexone (Revia)
48 Nalmefene in Nicotine and Alcohol Dependence Completed NCT00000437 Phase 4 Naltrexone Tablet and Nicotine Patch;Naltrexone Tablet and Placebo Patch;Placebo Tablet and Nicotine Patch;Placebo Tablet and Placebo Patch
49 A Double-Blind, Placebo-Controlled Trial of Lamotrigine In Individuals With Bipolar Disorder and Comorbid Alcohol Dependence Completed NCT01015586 Phase 4 Lamotrigine;Placebo
50 SSRI Treatment of Dual Diagnosis PTSD and Alcohol Dependence: A Test of the Serotonergic Hypothesis Completed NCT02504931 Phase 4 Sertraline;Placebo

Search NIH Clinical Center for Alcohol Dependence

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Citalopram
Citalopram hydrobromide
Disulfiram
Naltrexone
Naltrexone hydrochloride
Ondansetron
Ondansetron Hydrochloride

Genetic Tests for Alcohol Dependence

Genetic tests related to Alcohol Dependence:

# Genetic test Affiliating Genes
1 Alcohol Dependence 28 ADH1B ADH1C GABRA2 HTR2A TAS2R16

Anatomical Context for Alcohol Dependence

Organs/tissues related to Alcohol Dependence:

MalaCards : Liver, Brain, Prefrontal Cortex, Bone Marrow, Skeletal Muscle, Cortex, Endothelial

Publications for Alcohol Dependence

Articles related to Alcohol Dependence:

(show top 50) (show all 64092)
# Title Authors PMID Year
1
Alcohol and aldehyde dehydrogenase polymorphisms in men with type I and Type II alcoholism. 53 62 57 5
15863807 2005
2
Alcoholism and alcohol drinking habits predicted from alcohol dehydrogenase genes. 62 57 5
17923853 2008
3
Major genetic components underlying alcoholism in Korean population. 62 57 5
18056758 2008
4
Functional variants in TAS2R38 and TAS2R16 influence alcohol consumption in high-risk families of African-American origin. 62 57 5
17250611 2007
5
Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence. 62 57 5
16385453 2006
6
Alcoholism susceptibility loci: confirmation studies in a replicate sample and further mapping. 62 57 5
10923994 2000
7
Genome-wide search for genes affecting the risk for alcohol dependence. 62 57 5
9603606 1998
8
A regulatory variation in OPRK1, the gene encoding the kappa-opioid receptor, is associated with alcohol dependence. 53 62 57
18319328 2008
9
Association of alcohol dehydrogenase genes with alcohol dependence: a comprehensive analysis. 53 62 57
16571603 2006
10
CHRM2 gene predisposes to alcohol dependence, drug dependence and affective disorders: results from an extended case-control structured association study. 53 62 57
16000316 2005
11
Meta-analysis of the association of a functional serotonin transporter promoter polymorphism with alcohol dependence. 53 62 57
15635638 2005
12
Evidence of common and specific genetic effects: association of the muscarinic acetylcholine receptor M2 (CHRM2) gene with alcohol dependence and major depressive syndrome. 53 62 57
15229186 2004
13
A functional neuropeptide Y Leu7Pro polymorphism associated with alcohol dependence in a large population sample from the United States. 53 62 57
12215082 2002
14
Hangover symptoms in Asian Americans with variations in the aldehyde dehydrogenase (ALDH2) gene. 53 62 5
10627091 2000
15
Association between the functional variant of the catechol-O-methyltransferase (COMT) gene and type 1 alcoholism. 53 62 57
10395222 1999
16
Linkage disequilibrium at the ADH2 and ADH3 loci and risk of alcoholism. 53 62 5
10090900 1999
17
Integrating GWASs and human protein interaction networks identifies a gene subnetwork underlying alcohol dependence. 62 57
24268660 2013
18
Ordered subset linkage analysis based on admixture proportion identifies new linkage evidence for alcohol dependence in African-Americans. 62 57
23239122 2013
19
A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. 62 57
20332099 2010
20
ADH single nucleotide polymorphism associations with alcohol metabolism in vivo. 62 57
19193628 2009
21
Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis. 62 57
18996923 2009
22
The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk. 62 57
17622222 2008
23
Neurokinin 1 receptor antagonism as a possible therapy for alcoholism. 62 57
18276852 2008
24
Smoking and alcoholism target genes associated with plasticity and glutamate transmission in the human ventral tegmental area. 62 57
17928304 2008
25
Neurexin 3 polymorphisms are associated with alcohol dependence and altered expression of specific isoforms. 62 57
17804423 2007
26
Pharmacokinetic and pharmacodynamic basis for partial protection against alcoholism in Asians, heterozygous for the variant ALDH2*2 gene allele. 62 5
17885622 2007
27
The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants. 62 5
17718394 2007
28
Genomewide linkage study in the Irish affected sib pair study of alcohol dependence: evidence for a susceptibility region for symptoms of alcohol dependence on chromosome 4. 62 57
16534506 2006
29
Joint analysis of the NACP-REP1 marker within the alpha synuclein gene concludes association with alcohol dependence. 62 57
15731118 2005
30
Association of the -141C Del variant of the dopamine D2 receptor (DRD2) with positive family history and suicidality in German alcoholics. 62 57
15389757 2005
31
Haplotype-based localization of an alcohol dependence gene to the 5q34 {gamma}-aminobutyric acid type A gene cluster. 62 57
15630072 2005
32
Genomic screen for loci associated with alcohol dependence in Mission Indians. 62 57
15274051 2004
33
A genome wide search for alcoholism susceptibility genes. 62 57
15211641 2004
34
Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations. 62 5
15024690 2004
35
Confirmation and fine mapping of the chromosome 1 alcohol dependence risk locus. 62 57
15094791 2004
36
Ethanol consumption and DRD2 gene TaqI a polymorphism among socially drinking males. 62 57
12749054 2003
37
A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity. 62 5
12050823 2002
38
Evidence for a locus on chromosome 1 that influences vulnerability to alcoholism and affective disorder. 62 57
11329392 2001
39
Genetics of event-related brain potentials in response to a semantic priming paradigm in families with a history of alcoholism. 62 57
11102287 2001
40
Regulation of the mammalian alcohol dehydrogenase genes. 62 5
10697413 2000
41
Involvement of acetaldehyde for full protection against alcoholism by homozygosity of the variant allele of mitochondrial aldehyde dehydrogenase gene in Asians. 62 5
10780266 1999
42
Association of a polymorphism of the 5HT2A receptor gene promoter region with alcohol dependence. 62 57
10089015 1999
43
Recent progress toward the identification of genes related to risk for alcoholism. 62 57
9880654 1998
44
Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an American Indian population. 62 57
9603607 1998
45
Population and pedigree studies reveal a lack of association between the dopamine D2 receptor gene and alcoholism. 62 57
1979357 1990
46
Segregation analysis of alcoholism in families ascertained through a pair of male alcoholics. 62 57
2339688 1990
47
Allelic association of human dopamine D2 receptor gene in alcoholism. 62 57
1969501 1990
48
Biological markers for increased risk of alcoholism and for quantitation of alcohol consumption. 62 57
2298906 1990
49
Genetic investigations of alcohol metabolism and of alcoholism. 62 57
3189329 1988
50
Neurogenetic adaptive mechanisms in alcoholism. 62 57
2882604 1987

Variations for Alcohol Dependence

ClinVar genetic disease variations for Alcohol Dependence:

5 (show all 11)
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 ALDH2 NM_000690.4(ALDH2):c.1510G>A (p.Glu504Lys) SNV Protective
18390 rs671 GRCh37: 12:112241766-112241766
GRCh38: 12:111803962-111803962
2 ADH1B NM_000668.5(ADH1B):c.143A= (p.His48=) SNV Protective
Protective
18182 rs1229984 GRCh37: 4:100239319-100239319
GRCh38: 4:99318162-99318162
3 ADH1B NM_000668.6(ADH1B):c.1108C>T (p.Arg370Cys) SNV Protective
18183 rs2066702 GRCh37: 4:100229017-100229017
GRCh38: 4:99307860-99307860
4 ADH1C NM_000669.5(ADH1C):c.1048A>G (p.Ile350Val) SNV Protective
18180 rs698 GRCh37: 4:100260789-100260789
GRCh38: 4:99339632-99339632
5 ADH1C NM_000669.5(ADH1C):c.815G>A (p.Arg272Gln) SNV Protective
18179 rs1693482 GRCh37: 4:100263965-100263965
GRCh38: 4:99342808-99342808
6 LAMA2 DEL Pathogenic
1684643 GRCh37:
GRCh38: 6:128960376-129175759
7 GABRA2 NM_000807.4(GABRA2):c.995C>T (p.Ala332Val) SNV Pathogenic
1685836 GRCh37: 4:46264007-46264007
GRCh38: 4:46261990-46261990
8 TAS2R16 NM_016945.3(TAS2R16):c.516T>G (p.Asn172Lys) SNV Risk Factor
5333 rs846664 GRCh37: 7:122635173-122635173
GRCh38: 7:122995119-122995119
9 GABRA2 NM_000807.4(GABRA2):c.188-4371A>T SNV Risk Factor
16220 rs279836 GRCh37: 4:46339070-46339070
GRCh38: 4:46337053-46337053
10 GABRA2 NM_000807.4(GABRA2):c.255+4909A>T SNV Risk Factor
16219 rs279845 GRCh37: 4:46329723-46329723
GRCh38: 4:46327706-46327706
11 GABRA2 NM_000807.4(GABRA2):c.704-104A>G SNV Risk Factor
16218 rs279871 GRCh37: 4:46305733-46305733
GRCh38: 4:46303716-46303716

Copy number variations for Alcohol Dependence from CNVD:

6 (show top 50) (show all 130)
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 266214 X 94932922 94947252 Copy number Alcoholism
2 266039 X 92390816 92762114 Copy number Alcoholism
3 265901 X 91565635 91566714 Copy number PCDH11X Alcoholism
4 265754 X 88330836 88702538 Copy number Alcoholism
5 265534 X|Y 1415508 1461582 Copy number IL3RA Alcoholism
6 265533 X|Y 1347700 1388827 Copy number CSF2RA Alcoholism
7 265532 X|Y 1274886 1687565 Copy number CRLF2 Alcoholism
8 265493 X 81787612 81874294 Copy number Alcoholism
9 265343 X 78772193 78812486 Copy number Alcoholism
10 265228 X 76603730 77413482 Copy number TAF9B Alcoholism
11 265227 X 76603730 77413482 Copy number PGK1 Alcoholism
12 265226 X 76603730 77413482 Copy number PGAM4 Alcoholism
13 265225 X 76603730 77413482 Copy number MAGT1 Alcoholism
14 265224 X 76603730 77413482 Copy number COX7B Alcoholism
15 265223 X 76603730 77413482 Copy number ATRX Alcoholism
16 265222 X 76603730 77413482 Copy number ATP7A Alcoholism
17 264719 X 69649374 69651123 Copy number Alcoholism
18 264659 X 69202083 69224923 Copy number Alcoholism
19 264608 X 68611199 68653758 Copy number NALF2 Alcoholism
20 264492 X 66979215 67325231 Copy number OPHN1 Alcoholism
21 263977 X 56670955 56976220 Copy number Alcoholism
22 263947 X 55719150 55723443 Copy number Alcoholism
23 263229 X 47606948 48104013 Copy number ZNF81 Alcoholism
24 263228 X 47606948 48104013 Copy number ZNF630 Alcoholism
25 263227 X 47606948 48104013 Copy number ZNF182 Alcoholism
26 263226 X 47606948 48104013 Copy number SSX9P Alcoholism
27 263225 X 47606948 48104013 Copy number SSX6P Alcoholism
28 263224 X 47606948 48104013 Copy number SSX5 Alcoholism
29 263223 X 47606948 48104013 Copy number SSX3 Alcoholism
30 263222 X 47606948 48104013 Copy number SSX1 Alcoholism
31 263221 X 47606948 48104013 Copy number SPACA5B Alcoholism
32 263220 X 47606948 48104013 Copy number SPACA5 Alcoholism
33 263067 X 46317980 46319778 Copy number CHST7 Alcoholism
34 263009 X 4492766 5343179 Copy number Alcoholism
35 262674 X 38451004 38482237 Copy number Alcoholism
36 262660 X 38264819 38278229 Copy number Alcoholism
37 262535 X 3744745 3866531 Copy number Alcoholism
38 262227 X 32135176 33596767 Copy number DMD Alcoholism
39 262142 X 313250 313615 Copy number Alcoholism
40 262105 X 30675274 30840317 Copy number TAB3 Alcoholism
41 261601 X 22730409 23040521 Copy number DDX53 Alcoholism
42 261433 X 20045427 20077242 Copy number SCARNA9L Alcoholism
43 261432 X 20045427 20077242 Copy number EIF1AX Alcoholism
44 261307 X|Y 2147552 2429015 Copy number DHRSX Alcoholism
45 261306 X|Y 1674276 1721974 Copy number ASMT Alcoholism
46 261169 X|Y 214969 267627 Copy number PPP2R3B Alcoholism
47 261168 X|Y 132990 160020 Copy number PLCXD1 Alcoholism
48 261167 X|Y 161425 289293 Copy number GTPBP6 Alcoholism
49 261043 X 153846405 154689292 Copy number VBP1 Alcoholism
50 261042 X 153846405 154689292 Copy number TMLHE Alcoholism

Expression for Alcohol Dependence

Search GEO for disease gene expression data for Alcohol Dependence.

Pathways for Alcohol Dependence

Pathways related to Alcohol Dependence according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.98 ALDH2 CHRNA6 GABRA2 GABRR2 MAOA NRXN3
2
Show member pathways
12.84 MAOA CYP2E1 ALDH2 ADH7 ADH4 ADH1C
3
Show member pathways
12.59 MAOA CYP2E1 ALDH2 ADH7 ADH4 ADH1C
4
Show member pathways
11.76 MAOA ADH7 ADH4 ADH1C
5
Show member pathways
11.35 CYP2E1 ALDH9A1 ALDH2
6
Show member pathways
11.32 SLC6A4 SLC6A3 MAOA
7 11.16 CYP2E1 ALDH2 ADH1C ADH1B
8 11.12 SLC6A4 MAOA HTR2A
9
Show member pathways
11.02 SLC6A4 SLC6A3 MAOA ALDH2
10
Show member pathways
10.93 CYP2E1 ALDH9A1 ALDH2 ADH4 ADH1B
11
Show member pathways
10.92 SLC6A4 SLC6A3 MAOA DRD2
12 10.85 NRXN3 LAMA2
13 10.71 MAOA ALDH9A1 ADH7 ADH1B
14
Show member pathways
10.67 CYP2E1 ADH1B
15 10.66 ADH1C ADH1B
16
Show member pathways
10.51 ALDH2 ADH7 ADH4 ADH1C ADH1B
17 10.49 MAOA ALDH2

GO Terms for Alcohol Dependence

Cellular components related to Alcohol Dependence according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016021 10.61 CHRNA6 DRD2 GABRA2 GABRR2 HTR2A MAOA
2 membrane GO:0016020 10.61 CHRNA6 DRD2 GABRA2 GABRR2 HTR2A MAOA
3 plasma membrane GO:0005887 10.5 CHRNA6 DRD2 GABRA2 GABRR2 HTR2A NRXN3
4 plasma membrane GO:0005886 10.5 CHRNA6 DRD2 GABRA2 GABRR2 HTR2A NRXN3
5 neuron projection GO:0043005 10.21 CHRNA6 GABRA2 GABRR2 OPRK1 OPRM1 SLC6A3
6 synapse GO:0045202 10.2 CHRNA6 DRD2 GABRA2 GABRR2 HTR2A OPRK1
7 GABA-ergic synapse GO:0098982 9.98 NRXN3 GABRR2 GABRA2 DRD2
8 axon terminus GO:0043679 9.97 SLC6A3 OPRK1 DRD2
9 postsynaptic membrane GO:0045211 9.9 CHRNA6 DRD2 GABRA2 GABRR2 HTR2A OPRK1
10 dopaminergic synapse GO:0098691 9.88 SLC6A3 DRD2 CHRNA6
11 presynaptic membrane GO:0042734 9.86 SLC6A4 SLC6A3 OPRM1 OPRK1 HTR2A DRD2
12 obsolete integral component of presynaptic membrane GO:0099056 9.5 SLC6A4 SLC6A3 OPRM1 OPRK1 HTR2A DRD2
13 obsolete integral component of postsynaptic membrane GO:0099055 9.17 SLC6A4 SLC6A3 OPRM1 OPRK1 HTR2A DRD2

Biological processes related to Alcohol Dependence according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 response to xenobiotic stimulus GO:0009410 10.23 CYP2E1 DRD2 HTR2A SLC6A3 SLC6A4
2 chemical synaptic transmission GO:0007268 10.17 OPRK1 NRXN3 HTR2A GABRR2 GABRA2 CHRNA6
3 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 10.14 OPRM1 OPRK1 HTR2A
4 nervous system process GO:0050877 10.1 GABRR2 GABRA2 CHRNA6
5 neurotransmitter transport GO:0006836 10.08 SLC6A4 SLC6A3 GABRA2
6 excitatory postsynaptic potential GO:0060079 10.07 OPRM1 GABRR2 GABRA2 DRD2 CHRNA6
7 retinol metabolic process GO:0042572 10.06 ADH7 ADH4 ADH1C ADH1B
8 regulation of dopamine secretion GO:0014059 10.04 HTR2A DRD2 CHRNA6
9 sensory perception of pain GO:0019233 10.03 OPRM1 OPRK1 HTR2A
10 retinoid metabolic process GO:0001523 10.03 ADH7 ADH4 ADH1B
11 retinoic acid metabolic process GO:0042573 10.02 ADH1B ADH1C ADH7
12 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.96 HTR2A DRD2
13 cellular aldehyde metabolic process GO:0006081 9.96 ALDH9A1 ADH4
14 response to ethanol GO:0045471 9.96 ADH7 CYP2E1 DRD2 OPRK1 OPRM1 SLC6A3
15 behavioral response to ethanol GO:0048149 9.95 OPRM1 DRD2
16 monoamine transport GO:0015844 9.95 SLC6A3 SLC6A4
17 behavioral response to cocaine GO:0048148 9.95 DRD2 HTR2A OPRK1
18 dopamine catabolic process GO:0042420 9.94 MAOA SLC6A3
19 G protein-coupled opioid receptor signaling pathway GO:0038003 9.94 OPRM1 OPRK1
20 adenohypophysis development GO:0021984 9.93 SLC6A3 DRD2
21 response to morphine GO:0043278 9.93 OPRM1 OPRK1 DRD2
22 hyaloid vascular plexus regression GO:1990384 9.91 DRD2 SLC6A3
23 fatty acid omega-oxidation GO:0010430 9.91 ADH7 ADH4
24 dopamine uptake involved in synaptic transmission GO:0051583 9.89 SLC6A3 DRD2
25 regulation of postsynaptic membrane potential GO:0060078 9.88 GABRR2 GABRA2 CHRNA6
26 response to cocaine GO:0042220 9.87 SLC6A3 OPRM1 OPRK1 DRD2
27 adenylate cyclase-inhibiting opioid receptor signaling pathway GO:0031635 9.81 OPRM1 OPRK1
28 ethanol oxidation GO:0006069 9.76 ADH7 ADH4 ADH1C ADH1B
29 regulation of synaptic vesicle exocytosis GO:2000300 9.71 CHRNA6 DRD2 HTR2A NRXN3
30 presynaptic modulation of chemical synaptic transmission GO:0099171 9.67 HTR2A DRD2 CHRNA6
31 behavior GO:0007610 9.62 HTR2A OPRK1
32 postsynaptic signal transduction GO:0098926 9.52 OPRM1 OPRK1
33 small molecule metabolic process GO:0044281 9.26 ADH7 ADH4 ADH1C ADH1B
34 alcohol metabolic process GO:0006066 9.1 ALDH2 ADH4 ADH1C ADH1B

Molecular functions related to Alcohol Dependence according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential GO:1904315 10.01 GABRR2 GABRA2 CHRNA6
2 excitatory extracellular ligand-gated monoatomic ion channel activity GO:0005231 9.97 GABRR2 GABRA2 CHRNA6
3 neurotransmitter receptor activity GO:0030594 9.97 CHRNA6 GABRA2 GABRR2 HTR2A
4 monoamine transmembrane transporter activity GO:0008504 9.85 SLC6A4 SLC6A3
5 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity GO:0043878 9.83 ALDH9A1 ALDH2
6 dopamine binding GO:0035240 9.81 SLC6A3 DRD2
7 oxidoreductase activity GO:0016491 9.81 ADH1B ADH1C ADH4 ADH7 ALDH2 ALDH9A1
8 ethanol binding GO:0035276 9.73 ADH7 ADH4
9 alcohol dehydrogenase (NAD+) activity GO:0004022 9.73 ADH7 ADH4 ADH1C
10 G protein-coupled opioid receptor activity GO:0004985 9.65 OPRM1 OPRK1
11 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0016620 9.62 ALDH9A1 ALDH2 ADH4
12 extracellular ligand-gated monoatomic ion channel activity GO:0005230 9.58 GABRR2 GABRA2 CHRNA6
13 NAD-retinol dehydrogenase activity GO:0004745 9.56 ADH7 ADH4 ADH1C ADH1B
14 alcohol dehydrogenase [NAD(P)+] activity GO:0018455 9.46 ADH7 ADH1C
15 alcohol dehydrogenase activity, zinc-dependent GO:0004024 9.23 ADH7 ADH4 ADH1C ADH1B

Sources for Alcohol Dependence

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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