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MCID: ALC007
MIFTS: 65

Alcohol Dependence

Categories: Genetic diseases, Mental diseases, Cancer diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Alcohol Dependence

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MalaCards integrated aliases for Alcohol Dependence:

Name: Alcohol Dependence 57 12 76 37 29 6 15 40
Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against 57 13 6
Alcoholism 57 12 55
Alcohol Dependence, Protection Against 57 13
Alcohol Dependence, Susceptibility to 57 6
Pharyngeal Neoplasms 44 73
Alcoholic Intoxication, Chronic 73
Alcoholism, Susceptibility to 6

Characteristics:

OMIM:

57
Inheritance:
probably multifactorial, genetically influenced


Classifications:

MalaCards categories:
Global: Genetic diseases Cancer diseases
Anatomical: Mental diseases
See all MalaCards categories (disease lists)


External Ids:

OMIM 57 103780
Disease Ontology 12 DOID:0050741
MeSH 44 D010610
NCIt 50 C3325
SNOMED-CT 68 126685009 95001001
MedGen 42 C0001973
KEGG 37 H01611
SNOMED-CT via HPO 69 88425004
Sources

Summaries for Alcohol Dependence

About this section
MalaCards based summary : Alcohol Dependence, also known as aerodigestive tract cancer, squamous cell, alcohol-related, protection against, is related to alcohol abuse and psychotic disorder. An important gene associated with Alcohol Dependence is ADH1B (Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide), and among its related pathways/superpathways are Alcoholism and Peptide ligand-binding receptors. The drugs Ethanol and Gabapentin have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and testes, and related phenotypes are abnormality of the nervous system and alcoholism

Wikipedia : 76 Alcohol dependence is a previous psychiatric diagnosis in which an individual is physically or... more...

Description from OMIM: 103780
Sources

Related Diseases for Alcohol Dependence

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Diseases related to Alcohol Dependence via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 113)
# Related Disease Score Top Affiliating Genes
1 alcohol abuse 34.0 ALDH2 ALDH9A1 CYP2E1 DRD2 DRD4 GABRA2
2 psychotic disorder 32.5 DRD2 DRD4 HTR2A SLC6A3 SLC6A4
3 depression 32.1 HTR2A MAOA SLC6A4
4 drug dependence 31.8 DRD2 OPRK1 OPRM1 SLC6A4
5 conduct disorder 31.7 ALDH2 DRD2 DRD4 MAOA SLC6A3 SLC6A4
6 post-traumatic stress disorder 31.6 DRD2 HTR2A MAOA SLC6A4
7 opiate dependence 31.6 DRD2 OPRK1 OPRM1 SLC6A4
8 cocaine dependence 31.6 DRD2 OPRK1 OPRM1 SLC6A3 SLC6A4
9 antisocial personality disorder 31.6 ALDH2 DRD2 HTR1B MAOA SLC6A3 SLC6A4
10 personality disorder 31.5 ALDH2 DRD2 DRD4 HTR1B HTR2A MAOA
11 bipolar disorder 31.5 DRD2 DRD4 HTR2A MAOA SLC6A3 SLC6A4
12 anxiety 31.5 HTR2A MAOA SLC6A4
13 schizophrenia 31.5 DRD2 DRD4 HTR1B HTR2A MAOA SLC6A3
14 cocaine abuse 31.5 DRD2 SLC6A3 SLC6A4
15 pathological gambling 31.4 DRD2 DRD4 HTR2A MAOA SLC6A3 SLC6A4
16 tobacco addiction 31.4 ALDH2 DRD2 HTR2A MAOA OPRM1 SLC6A3
17 major depressive disorder 31.3 DRD2 DRD4 HTR1B HTR2A MAOA SLC6A3
18 alcoholic pancreatitis 31.2 ADH1B ALDH2 CYP2E1
19 attention deficit-hyperactivity disorder 31.2 DRD2 DRD4 HTR1B HTR2A MAOA OPRM1
20 mood disorder 31.1 DRD2 DRD4 HTR1B HTR2A MAOA SLC6A4
21 alcoholic liver cirrhosis 31.1 ADH1B ADH1C ADH4 ALDH2 CYP2E1
22 opioid addiction 31.1 DRD2 OPRK1 OPRM1
23 social phobia 31.1 DRD2 MAOA SLC6A4
24 phobic disorder 31.1 MAOA OPRK1 SLC6A4
25 gilles de la tourette syndrome 31.1 DRD2 DRD4 SLC6A3
26 substance dependence 31.1 ADH4 DRD2 DRD4 HTR1B MAOA OPRK1
27 disease of mental health 31.1 ADH1B ALDH2 DRD2 DRD4 HTR2A MAOA
28 dysthymic disorder 31.0 HTR2A MAOA SLC6A4
29 agoraphobia 31.0 MAOA OPRK1 SLC6A4
30 generalized anxiety disorder 31.0 DRD2 HTR2A MAOA SLC6A4
31 borderline personality disorder 31.0 HTR1B HTR2A MAOA SLC6A4
32 paranoid schizophrenia 30.9 HTR2A MAOA SLC6A4
33 oppositional defiant disorder 30.9 DRD2 DRD4 MAOA SLC6A3 SLC6A4
34 substance abuse 30.9 DRD2 DRD4 GABRA2 HTR1B MAOA SLC6A3
35 schizoaffective disorder 30.9 DRD2 HTR2A SLC6A4
36 obsessive-compulsive disorder 30.9 DRD2 DRD4 HTR1B HTR2A MAOA SLC6A3
37 delusional disorder 30.8 DRD2 DRD4
38 panic disorder 30.3 HTR2A MAOA SLC6A4
39 alcohol-induced mental disorder 11.3 DRD2 SLC6A3 SLC6A4
40 periodic limb movement disorder 11.2 DRD2 HTR2A SLC6A4
41 alcoholic psychosis 11.2 DRD2 HTR2A SLC6A3 SLC6A4
42 bruxism 11.2 DRD2 HTR2A SLC6A4
43 methanol poisoning 11.2 ADH1B ADH1C CYP2E1
44 premature ejaculation 11.2 HTR1B SLC6A3 SLC6A4
45 heroin dependence 11.2 DRD2 DRD4 OPRM1
46 beta-glucopyranoside tasting 11.2
47 alzheimer disease 5 11.2 HTR2A SLC6A4
48 migraine with aura 11.2 DRD2 HTR1B SLC6A3 SLC6A4
49 tic disorder 11.2 DRD2 DRD4 HTR2A SLC6A3
50 specific developmental disorder 11.2 DRD4 OPRM1 SLC6A3 SLC6A4

Graphical network of the top 20 diseases related to Alcohol Dependence:



Diseases related to Alcohol Dependence
Sources

Symptoms & Phenotypes for Alcohol Dependence

About this section

Symptoms via clinical synopsis from OMIM:

57
Neuro:
alcoholism

Misc:
25 to 50% lifetime risk for sons and brothers of severely alcoholic men


Clinical features from OMIM:

103780

Human phenotypes related to Alcohol Dependence:

32
# Description HPO Frequency HPO Source Accession
1 abnormality of the nervous system 32 HP:0000707
2 alcoholism 32 HP:0030955

MGI Mouse Phenotypes related to Alcohol Dependence:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.13 SLC6A3 DRD4 GABRA2 SLC6A4 HTR1B ADH7
2 homeostasis/metabolism MP:0005376 9.97 DRD4 SLC6A3 GABRA2 SLC6A4 GATA4 ADH1C
3 endocrine/exocrine gland MP:0005379 9.91 DRD2 SLC6A3 SLC6A4 GATA4 HTR1B HTR2A
4 integument MP:0010771 9.61 SLC6A3 GABRA2 SLC6A4 GATA4 ALDH2 OPRK1
5 nervous system MP:0003631 9.36 DRD4 SLC6A3 GABRA2 SLC6A4 GATA4 ADH7
Sources

Drugs & Therapeutics for Alcohol Dependence

About this section

Drugs for Alcohol Dependence (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 471)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 64-17-5 702
2
Gabapentin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 60142-96-3 3446
3
gamma-Aminobutyric acid Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 56-12-2 119
4
Acamprosate Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 77337-76-9 71158
5
Topiramate Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 97240-79-4 5284627
6
Naltrexone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 16590-41-3 5360515
7
Lamotrigine Approved, Investigational Phase 4,Phase 3 84057-84-1 3878
8
Bupropion Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 34841-39-9, 34911-55-2 444
9
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 51-61-6, 62-31-7 681
10
Fluoxetine Approved, Vet_approved Phase 4,Phase 2 54910-89-3 3386
11
Disulfiram Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 97-77-8 3117
12
Prazosin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 19216-56-9 4893
13
Histamine Approved, Investigational Phase 4,Phase 2,Not Applicable 75614-87-8, 51-45-6 774
14
Varenicline Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 249296-44-4 5310966
15
Cocaine Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-36-2 5760 446220
16
Valproic Acid Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 99-66-1 3121
17
Ondansetron Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 99614-02-5 4595
18
Oxytocin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-56-6 439302 53477758
19
Zonisamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 68291-97-4 5734
20
Lorazepam Approved Phase 4,Phase 2,Phase 1 846-49-1 3958
21
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1994-09-7, 94-09-7 2337
22
Sertraline Approved Phase 4,Phase 2,Phase 1 79617-96-2 68617
23
Nicotine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 54-11-5 942 89594
24
Methylphenidate Approved, Investigational Phase 4,Phase 1,Early Phase 1 113-45-1 4158
25
Aripiprazole Approved, Investigational Phase 4,Phase 2,Phase 3 129722-12-9 60795
26
Citalopram Approved Phase 4,Phase 2,Phase 1,Not Applicable 59729-33-8 2771
27
Memantine Approved, Investigational Phase 4,Phase 3,Phase 2 19982-08-2 4054
28
Oxazepam Approved Phase 4 604-75-1 4616
29
Sodium oxybate Approved Phase 4 502-85-2 5360545
30 Piracetam Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 7491-74-9
31
Paroxetine Approved, Investigational Phase 4,Phase 3 61869-08-7 43815
32
Baclofen Approved Phase 4,Phase 2,Phase 3,Phase 1 1134-47-0 2284
33
Carbamazepine Approved, Investigational Phase 4 298-46-4 2554
34
Dutasteride Approved, Investigational Phase 4,Not Applicable 164656-23-9 152945 6918296
35
Icodextrin Approved, Investigational Phase 4 337376-15-5
36
Methadone Approved Phase 4,Phase 2 76-99-3 4095
37
Ribavirin Approved Phase 4,Phase 2 36791-04-5 37542
38
Simvastatin Approved Phase 4 79902-63-9 54454
39
Chlorzoxazone Approved Phase 4,Not Applicable 95-25-0 2733
40
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4 52485-79-7 40400 644073
41
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 2 93-14-1 3516
42
Naloxone Approved, Vet_approved Phase 4,Phase 3,Phase 1 465-65-6 5284596
43
Risperidone Approved, Investigational Phase 4,Phase 2 106266-06-2 5073
44
Acetylcysteine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 616-91-1 12035
45
Acetylcholine Approved Phase 4,Phase 2 51-84-3 187
46
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2 148553-50-8 5486971
47
Heroin Approved, Illicit, Investigational Phase 4,Phase 2,Phase 1 561-27-3 5462328
48
Olanzapine Approved, Investigational Phase 4,Phase 3,Phase 2 132539-06-1 4585
49
Lenograstim Approved, Investigational Phase 4 135968-09-1
50
Pentoxifylline Approved, Investigational Phase 4,Phase 2,Phase 3 6493-05-6 4740

Interventional clinical trials:

(show top 50) (show all 1112)
# Name Status NCT ID Phase Drugs
1 Treatment for Alcohol Dependence With Gabapentin Unknown status NCT02771925 Phase 4 Gabapentin 2g/day divided in two doses for 24 weeks;Placebo 2g/day divided in two doses for 24 weeks
2 Safety of Acamprosate for Alcohol Dependence in the Elderly: An Open-Label Study (SAFADIE) Unknown status NCT00655967 Phase 4 Acamprosate (Campral);Acamprosate
3 Topiramate for Hospitalized Patients With Alcoholism: a 12-week Study Unknown status NCT01135602 Phase 4 Topiramate
4 Trial for the Treatment of Alcohol Dependence Unknown status NCT00120601 Phase 4 Naltrexone;Acamprosate
5 Treatment of Alcohol Dependence and Comorbid Bipolar Disorder Unknown status NCT01015586 Phase 4 Lamotrigine;Placebo
6 Fluoxetine and Bupropion to Treat Patients With Depression and Alcoholism Unknown status NCT00449007 Phase 4 fluoxetine;bupropion
7 Antabuse in Severe Alcoholism: an Open Controlled Study Unknown status NCT00431262 Phase 4 antabuse (disulfiram)
8 Acamprosate vs. Placebo in Bipolar Alcoholics Unknown status NCT00466661 Phase 4 Acamprosate;Placebo
9 Citicoline for Alcohol Dependence Completed NCT02074735 Phase 4 Placebo;Citicoline
10 Extended-release Naltrexone for Alcohol Dependence in Primary Care Completed NCT00620750 Phase 4 Extended release injectable naltrexone (Vivitrol)
11 Study of Campral (Acamprosate) for Alcohol Dependence in a Family Medicine Clinic Completed NCT00381043 Phase 4 Acamprosate (Campral)
12 Zonisamide vs. Placebo in the Treatment of Alcohol Dependence Completed NCT00595556 Phase 4 zonisamide;Placebo
13 A Randomized Clinical Trial of Alcohol Care Management Completed NCT00419315 Phase 4
14 Trial of Seroquel SR for Alcohol Dependence and Comorbid Anxiety Completed NCT00352469 Phase 4 Seroquel XR
15 Disulfiram Combined With Lorazepam for Alcohol Dependence and Anxiety Disorder Completed NCT00721526 Phase 4 disulfiram plus lorazepam
16 Adjunctive Topiramate for Treatment of Alcohol Dependence in Patients With Bipolar Disorder Completed NCT00572117 Phase 4 Topiramate
17 Identifying Multiple Mechanisms of Change in Alcoholism Treatment Completed NCT01168960 Phase 4
18 Pharmacogenetic Response to Naltrexone For Alcohol Dependence Completed NCT00831272 Phase 4 naltrexone;Placebo
19 Prazosin Alcohol Dependence IVR Study Completed NCT00167687 Phase 4 prazosin
20 Injectable Versus Oral Naltrexone Treatment of Alcohol Dependence In Serious Mental Illness (SMI) Completed NCT00453804 Phase 4 injectable naltrexone;oral naltrexone
21 Sertraline Pharmacotherapy for Alcoholism Subtypes Completed NCT00368550 Phase 4 Sertraline;Placebo
22 Comparative Trial Of Disulfiram, Naltrexone And Acamprosate In The Treatment Of Alcohol Dependence Completed NCT00435435 Phase 4 Disulfiram;Acamprosate;Naltexone
23 Naltrexone for Bipolar Disorder and Alcohol Dependence Completed NCT00223275 Phase 4 Naltrexone
24 Injectable Naltrexone Treatment of Alcohol Dependence in Serious Mental Illness (SMI) Completed NCT00453609 Phase 4 long-lasting injectable naltrexone
25 Genetic and Brain Mechanisms of Naltrexone's Treatment Efficacy for Alcoholism Completed NCT00920829 Phase 4 Naltrexone 50 Mg;Placebo
26 Quetiapine for Bipolar Disorder and Alcohol Dependence Completed NCT00457197 Phase 4 Placebo;Quetiapine
27 Tobacco Dependence in Alcoholism Treatment (Nicotine Patch/Naltrexone) Completed NCT00000437 Phase 4 Naltrexone Tablet and Nicotine Patch;Naltrexone Tablet and Placebo Patch;Placebo Tablet and Nicotine Patch;Placebo Tablet and Placebo Patch
28 Treatment of Patients With Alcoholism and Attention Deficit Disorder Completed NCT00261872 Phase 4 Methylphenidate
29 Managing Alcoholism in People Who Do Not Respond to Naltrexone Completed NCT00115037 Phase 4 Naltrexone;placebo
30 Behavioral Therapy Plus Naltrexone for Alcoholism Completed NCT00000456 Phase 4 naltrexone (Revia)
31 Treatment for Alcoholism and Post-Traumatic Stress Disorder (Naltrexone) Completed NCT00006489 Phase 4 Naltrexone;Placebo
32 Naltrexone Treatment for Alcoholism Completed NCT00000438 Phase 4 naltrexone (Revia)
33 Individually Adapted Therapy of Alcoholism Completed NCT00317031 Phase 4 Acamprosate or Naltrexone
34 Naltrexone Treatment of Alcohol Dependence Completed NCT00000452 Phase 4 naltrexone (Revia)
35 Sertraline for Alcohol Dependence and Depression Completed NCT00004554 Phase 4 naltrexone (Revia);sertraline (Zoloft);Placebo
36 Naltrexone Maintenance Treatment of Alcoholism Completed NCT00000450 Phase 4 Naltrexone Tablet;Matched Placebo Tablet
37 Treatment of Patients Suffering of Alcohol Dependence and Impaired Liver Function With Selincro® As-needed Use Completed NCT02197598 Phase 4 nalmefene
38 Study of Aripiprazole in Subjects With Alcoholism Completed NCT00082199 Phase 4 Aripiprazole;Placebo
39 Smoking Cessation in Alcoholism Treatment Completed NCT00000454 Phase 4 nicotine replacement patch
40 Effectiveness of Naltrexone Versus Placebo to Reduce Craving for Alcohol With Evaluation of Genetic Variability. Completed NCT00366626 Phase 4 Naltrexone;Placebo
41 Efficacy Study of Memantine Hydrochloride and Escitalopram for the Treatment of Co-Morbid Depression and Alcoholism. Completed NCT00368862 Phase 4 Ebixa (memantine hydrochloride);Cipralex (escitalopram)
42 Acamprosate in Alcoholics With Comorbid Anxiety or Depression Completed NCT00330174 Phase 4 Acamprosate
43 The Effects of Topiramate on Alcohol Use in Alcohol Dependent Subjects Completed NCT00329407 Phase 4 Topiramate (Topamax)
44 ALK21-018: Effects of Medisorb® Naltrexone (VIVITROL®) on Alcohol Craving in Treatment-seeking, Alcohol-dependent Adults Completed NCT00511836 Phase 4 VIVITROL 380 mg;Placebo
45 Naltrexone for Relapse Prevention Completed NCT00000442 Phase 4 naltrexone (Revia)
46 Comparative Study of Gamma-hydroxy Butyrate Versus Oxazepam in the Treatment of Alcohol Withdrawal Syndrome Completed NCT02090504 Phase 4 Sodium Oxybate (SMO);Oxazepam
47 The Effects of Levetiracetam on Alcohol Dependent Subjects Completed NCT00325182 Phase 4 Levetiracetam
48 Paroxetine for Comorbid Social Anxiety Disorder and Alcoholism Completed NCT00246441 Phase 4 Paroxetine;Placebo
49 Integrative Therapy in Alcoholism Completed NCT00159107 Phase 4 Acamprosate;Placebo
50 High Dose Vitamin B1 to Reduce Abusive Alcohol Use Completed NCT00680121 Phase 4 Benfotiamine;Placebo

Search NIH Clinical Center for Alcohol Dependence

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: pharyngeal neoplasms

Sources

Genetic Tests for Alcohol Dependence

About this section

Genetic tests related to Alcohol Dependence:

# Genetic test Affiliating Genes
1 Alcohol Dependence 29 ADH1B ADH1C GABRA2 HTR2A RCBTB1 TAS2R16
Sources

Anatomical Context for Alcohol Dependence

About this section

MalaCards organs/tissues related to Alcohol Dependence:

41
Brain, Liver, Testes, Cortex, Pituitary, Amygdala, Lung
Sources

Publications for Alcohol Dependence

About this section

Articles related to Alcohol Dependence:

(show top 50) (show all 1401)
# Title Authors Year
1
Treatment of alcohol dependence. Alcohol and homelessness: social point of view. ( 29912211 )
2018
2
Is family history of alcohol dependence a risk factor for disturbed sleep in alcohol dependent subjects? ( 29843109 )
2018
3
Corneal endothelial alterations in alcohol dependence syndrome. ( 29305345 )
2018
4
Prevalence Estimates of ADHD in a Sample of Inpatients With Alcohol Dependence. ( 29308693 )
2018
5
Short message service (SMS) reminders improve treatment attendance in alcohol dependence, but are less effective for patients high in impulsivity. ( 29975880 )
2018
6
Italian Guidelines for the treatment of alcohol dependence. ( 29912210 )
2018
7
Religiosity, Guilt, Altruism and Forgiveness in Alcohol Dependence: Results of a Cross-sectional and Prospective Cohort Study. ( 29912267 )
2018
8
Lack of association between MTHFR C677T Gene polymorphism with alcohol dependence: A meta-analysis of case-control studies. ( 29953924 )
2018
9
Self-defining memories related to alcohol dependence and their integration in the construction of the self in a sample of abstinent alcoholics. ( 29944064 )
2018
10
The need for precise answers for the goals of precision medicine in alcohol dependence to succeed. ( 29930386 )
2018
11
Mecamylamine treatment for alcohol dependence: a randomized controlled trial. ( 28710873 )
2018
12
Treatment of alcohol dependence. Alcohol and the young: social point of view. ( 29912212 )
2018
13
Dialectical Behavior Therapy Skills Training in Alcohol Dependence Treatment: Findings Based on an Open Trial. ( 29958050 )
2018
14
Association of alcohol dehydrogenase 1C gene *1/*2 polymorphism with alcohol Dependence(AD) in Turkey: A meta-analysis. ( 29438797 )
2018
15
Predictors of Utilization of an Addiction-Specific Behavioural Couple Therapy in Alcohol Dependence. ( 29902784 )
2018
16
How do people with homelessness and alcohol dependence cope when alcohol is unaffordable? A comparison of residents of Canadian managed alcohol programs and locally recruited controls. ( 29314309 )
2018
17
Effects of alcohol dependence on discrete choice between alcohol and saccharin. ( 29875449 )
2018
18
Effect of electronic brief intervention on uptake of specialty treatment in hospital outpatients with likely alcohol dependence: Pilot randomized trial and qualitative interviews. ( 29306817 )
2018
19
Efficacy, tolerability, and safety of low-dose and high-dose baclofen in the treatment of alcohol dependence: A systematic review and meta-analysis. ( 29934090 )
2018
20
Effect of Interaction Between Duration of Alcohol Consumption and Alcohol Dependence on Thyroid Function Test: Cross Sectional Observational Study. ( 29371771 )
2018
21
Sex differences in the ACTH and cortisol response to pharmacological probes are stressor-specific and occur regardless of alcohol dependence history. ( 29763783 )
2018
22
Response to Letter to Editor (Precision medicine in alcohol dependence: evidence of efficacy and initial support for comparative effectiveness). ( 29930387 )
2018
23
Impulsive Personality Traits Mediate the Relationship Between Adult Attention-Deficit/Hyperactivity Symptoms and Alcohol Dependence Severity. ( 29063627 )
2018
24
Polygenic Risk Score Prediction of Alcohol Dependence Symptoms Across Population-Based and Clinically Ascertained Samples. ( 29405378 )
2018
25
Intestinal dysbiosis and permeability: the yin and yang in alcohol dependence and alcoholic liver disease. ( 29352076 )
2018
26
Repetitive transcranial magnetic stimulation (rTMS) in alcohol dependence: study protocol of a randomized controlled clinical trial of efficacy and working mechanisms. ( 29866086 )
2018
27
Identification and medical utilization of incident cases of alcohol dependence: A population-based case-control study. ( 29778776 )
2018
28
Influence of Parental Alcohol Dependence Symptoms and Parenting on Adolescent Risky Drinking and Conduct Problems: A Family Systems Perspective. ( 29969154 )
2018
29
The Speed of Progression to Tobacco and Alcohol Dependence: A Twin Study. ( 29427143 )
2018
30
Treatment for Alcohol Dependence in Primary Care Compared to Outpatient Specialist Treatment-A Randomized Controlled Trial. ( 29346473 )
2018
31
Decoding diagnosis and lifetime consumption in alcohol dependence from grey-matter pattern information. ( 29377059 )
2018
32
Shared genetic etiology between alcohol dependence and major depressive disorder. ( 29901528 )
2018
33
Automatic visual-spatial perspective taking in alcohol-dependence: A study with happy emotional faces. ( 29966852 )
2018
34
Activation of neural stem cells from quiescence drives reactive hippocampal neurogenesis after alcohol dependence. ( 29378214 )
2018
35
Lower limbic metabotropic glutamate receptor 5 availability in alcohol dependence. ( 29348321 )
2018
36
Nicotine-Use/Smoking Is Associated with the Efficacy of Naltrexone in the Treatment of Alcohol Dependence. ( 29431852 )
2018
37
A Call to Action for Treatment of Comorbid Tobacco and Alcohol Dependence. ( 29261821 )
2018
38
Heterogeneity of emotional and interpersonal difficulties in alcohol-dependence: A cluster analytic approach. ( 28411505 )
2017
39
Decreased hippocampal translocator protein (18a88kDa) expression in alcohol dependence: a [(11)C]PBR28 PET study. ( 28072413 )
2017
40
Benzodiazepine maintenance for alcohol dependence: A case series. ( 29302560 )
2017
41
Prevalence of pathological gambling in patients with alcohol dependence syndrome attending a tertiary care center in South India. ( 28483101 )
2017
42
Place and recovery from alcohol dependence: A journey through photovoice. ( 28886441 )
2017
43
Higher Impulsivity and HIV-Risk Taking Behaviour in Males with Alcohol Dependence Compared to Bipolar Mania: A Pilot Study. ( 28456858 )
2017
44
Health-related quality of life in alcohol dependence: Similar cross-cultural impact beyond specific drinking habits. ( 28805530 )
2017
45
An association between genetic variation in the glutamatergic system and suicide attempts in alcohol-dependent individuals. ( 28558131 )
2017
46
COMT and BDNF Gene Variants Help to Predict Alcohol Consumption in Alcohol-dependent Patients. ( 27898499 )
2017
47
Hepatic, lipid and genetic factors associated with obesity: crosstalk with alcohol dependence? ( 27905213 )
2017
48
Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis. ( 28714907 )
2017
49
Association between oxytocin and receptor genetic polymorphisms and aggression in a northern Chinese Han population with alcohol dependence. ( 27818356 )
2017
50
Sexual dysfunction in women with alcohol dependence syndrome: A study from India. ( 28784408 )
2017