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MCID: ALC007
MIFTS: 68

Alcohol Dependence

Categories: Cancer diseases, Genetic diseases, Mental diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Alcohol Dependence

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MalaCards integrated aliases for Alcohol Dependence:

Name: Alcohol Dependence 57 12 76 37 29 6 15 40
Alcoholism 57 12 55 15
Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against 57 13 6
Alcohol Dependence, Protection Against 57 13
Alcohol Dependence, Susceptibility to 57 6
Alcoholic Intoxication, Chronic 73
Alcoholism, Susceptibility to 6
Pharyngeal Neoplasms 73

Characteristics:

OMIM:

57
Inheritance:
probably multifactorial, genetically influenced


Classifications:

MalaCards categories:
Global: Genetic diseases Cancer diseases
Anatomical: Mental diseases
See all MalaCards categories (disease lists)


External Ids:

OMIM 57 103780
Disease Ontology 12 DOID:0050741
SNOMED-CT 68 66590003
MedGen 42 C0001973
KEGG 37 H01611
SNOMED-CT via HPO 69 88425004
Sources

Summaries for Alcohol Dependence

About this section
MalaCards based summary : Alcohol Dependence, also known as alcoholism, is related to fetal alcohol syndrome and alcoholic neuropathy. An important gene associated with Alcohol Dependence is ADH1B (Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide), and among its related pathways/superpathways are Alcoholism and Peptide ligand-binding receptors. The drugs Ethanol and Gabapentin have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and liver, and related phenotypes are abnormality of the nervous system and alcoholism

Wikipedia : 76 Alcohol dependence is a previous psychiatric diagnosis in which an individual is physically or... more...

Description from OMIM: 103780
Sources

Related Diseases for Alcohol Dependence

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Diseases related to Alcohol Dependence via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1208)
# Related Disease Score Top Affiliating Genes
1 fetal alcohol syndrome 34.5 ALDH2 ADH7 ADH1B
2 alcoholic neuropathy 34.3 ALDH2 ADH4
3 alcoholic psychosis 34.1 SLC6A4 SLC6A3 HTR2A DRD2
4 alcohol-induced mental disorder 33.8 SLC6A4 SLC6A3 DRD2
5 alcohol abuse 33.2 SLC6A4 HTR2A GABRA2 DRD4 DRD2 CYP2E1
6 restless legs syndrome 32.0 SLC6A3 MAOA DRD2
7 psychotic disorder 31.5 SLC6A4 SLC6A3 HTR2A DRD4 DRD2
8 migraine with or without aura 1 31.5 SLC6A4 SLC6A3 MAOA HTR2A HTR1B DRD4
9 methanol poisoning 31.3 CYP2E1 ADH1C ADH1B
10 depression 31.3 SLC6A4 MAOA HTR2A
11 anxiety 31.1 SLC6A4 MAOA HTR2A
12 schizophrenia 30.7 DRD2 DRD4 HTR1B HTR2A MAOA SLC6A3
13 personality disorder 30.7 SLC6A4 SLC6A3 MAOA HTR2A HTR1B DRD4
14 conduct disorder 30.6 SLC6A4 SLC6A3 MAOA DRD4 DRD2 ALDH2
15 drug dependence 30.6 SLC6A4 OPRM1 OPRK1 DRD2 CHRNA6
16 bipolar disorder 30.6 SLC6A4 SLC6A3 MAOA HTR2A DRD4 DRD2
17 pathological gambling 30.6 SLC6A4 SLC6A3 MAOA HTR2A DRD4 DRD2
18 opiate dependence 30.5 SLC6A4 OPRM1 OPRK1 DRD2
19 post-traumatic stress disorder 30.5 SLC6A4 MAOA HTR2A DRD2
20 liver cirrhosis 30.5 CYP2E1 ALDH2 ADH1C ADH1B
21 antisocial personality disorder 30.5 SLC6A4 SLC6A3 MAOA HTR1B DRD2 ALDH2
22 major depressive disorder 30.5 SLC6A4 SLC6A3 MAOA HTR2A HTR1B DRD4
23 tobacco addiction 30.4 TAS2R16 SLC6A4 SLC6A3 OPRM1 MAOA HTR2A
24 attention deficit-hyperactivity disorder 30.4 SLC6A4 SLC6A3 OPRM1 MAOA HTR2A HTR1B
25 cocaine dependence 30.4 SLC6A4 SLC6A3 OPRM1 OPRK1 DRD2
26 eating disorder 30.3 SLC6A4 SLC6A3 DRD2
27 autism 30.3 DRD2 DRD4 HTR2A MAOA SLC6A3 SLC6A4
28 mood disorder 30.2 SLC6A4 MAOA HTR2A HTR1B DRD4 DRD2
29 substance dependence 30.2 SLC6A4 SLC6A3 OPRM1 OPRK1 MAOA HTR1B
30 disease of mental health 30.2 SLC6A4 SLC6A3 OPRM1 MAOA HTR2A DRD4
31 alcoholic liver cirrhosis 30.2 CYP2E1 ALDH2 ADH4 ADH1C ADH1B
32 substance abuse 30.2 SLC6A4 SLC6A3 MAOA HTR1B GABRA2 DRD4
33 heroin dependence 30.2 DRD2 DRD4 OPRM1
34 cocaine abuse 30.2 SLC6A4 SLC6A3 DRD2
35 alcoholic pancreatitis 30.1 CYP2E1 ALDH2 ADH1B
36 gilles de la tourette syndrome 30.1 SLC6A3 DRD4 DRD2
37 endogenous depression 30.0 SLC6A4 MAOA HTR2A
38 obsessive-compulsive disorder 30.0 SLC6A4 SLC6A3 MAOA HTR2A HTR1B DRD4
39 opioid addiction 30.0 OPRM1 OPRK1 DRD2
40 social phobia 29.9 SLC6A4 MAOA DRD2
41 phobic disorder 29.9 SLC6A4 OPRK1 MAOA
42 dysthymic disorder 29.9 MAOA HTR2A SLC6A4
43 agoraphobia 29.9 SLC6A4 OPRK1 MAOA
44 generalized anxiety disorder 29.9 SLC6A4 MAOA HTR2A DRD2
45 paranoid schizophrenia 29.9 SLC6A4 MAOA HTR2A
46 schizoaffective disorder 29.9 SLC6A4 HTR2A DRD2
47 mental depression 29.9 SLC6A4 MAOA HTR2A
48 bulimia nervosa 29.9 SLC6A4 HTR2A HTR1B
49 borderline personality disorder 29.9 SLC6A4 MAOA HTR2A HTR1B
50 oppositional defiant disorder 29.9 SLC6A4 SLC6A3 MAOA DRD4 DRD2

Graphical network of the top 20 diseases related to Alcohol Dependence:



Diseases related to Alcohol Dependence
Sources

Symptoms & Phenotypes for Alcohol Dependence

About this section

Symptoms via clinical synopsis from OMIM:

57
Neuro:
alcoholism

Misc:
25 to 50% lifetime risk for sons and brothers of severely alcoholic men


Clinical features from OMIM:

103780

Human phenotypes related to Alcohol Dependence:

32
# Description HPO Frequency HPO Source Accession
1 abnormality of the nervous system 32 HP:0000707
2 alcoholism 32 HP:0030955

GenomeRNAi Phenotypes related to Alcohol Dependence according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00106-A-0 10.1 MAOA
2 Decreased viability GR00221-A-1 10.1 GABRA2
3 Decreased viability GR00221-A-2 10.1 GABRA2
4 Decreased viability GR00221-A-4 10.1 GABRA2
5 Decreased viability GR00381-A-1 10.1 ADH1C ADH4 SLC6A4
6 Decreased viability GR00381-A-3 10.1 SLC6A4
7 Decreased viability GR00402-S-2 10.1 ADH1B ADH1C ADH4 ADH7 ALDH2 ALDH9A1
8 no effect GR00402-S-1 9.62 ADH1B ADH1C ADH4 ADH7 ALDH2 ALDH9A1

MGI Mouse Phenotypes related to Alcohol Dependence:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.18 ADH7 ALDH2 CYP2E1 DRD2 DRD4 GABRA2
2 homeostasis/metabolism MP:0005376 10.07 ADH1C ADH7 ALDH2 CYP2E1 DRD2 DRD4
3 endocrine/exocrine gland MP:0005379 9.97 ALDH2 DRD2 GATA4 HTR1B HTR2A OPRK1
4 integument MP:0010771 9.81 ALDH2 ALDH9A1 DRD2 GABRA2 GATA4 OPRK1
5 muscle MP:0005369 9.5 ALDH2 DRD2 GATA4 HTR1B HTR2A SLC6A3
6 nervous system MP:0003631 9.4 ADH7 ALDH2 CHRNA6 DRD2 DRD4 GABRA2
Sources

Drugs & Therapeutics for Alcohol Dependence

About this section

Drugs for Alcohol Dependence (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 484)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 64-17-5 702
2
Gabapentin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 60142-96-3 3446
3
gamma-Aminobutyric acid Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 56-12-2 119
4
Acamprosate Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 77337-76-9 71158
5
Topiramate Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 97240-79-4 5284627
6
Naltrexone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 16590-41-3 5360515
7
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2 148553-50-8 5486971
8
Fluoxetine Approved, Vet_approved Phase 4,Phase 2 54910-89-3 3386
9
Bupropion Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 34841-39-9, 34911-55-2 444
10
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 51-61-6, 62-31-7 681
11
Disulfiram Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 97-77-8 3117
12
Cocaine Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-36-2 5760 446220
13
Acetylcysteine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 616-91-1 12035
14
Prazosin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 19216-56-9 4893
15
Varenicline Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 249296-44-4 5310966
16
Valproic Acid Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 99-66-1 3121
17
Oxytocin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-56-6 439302 53477758
18
Naloxone Approved, Vet_approved Phase 4,Phase 3,Phase 1 465-65-6 5284596
19
Ondansetron Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 99614-02-5 4595
20
Zonisamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 68291-97-4 5734
21
Lorazepam Approved Phase 4,Phase 2,Phase 1 846-49-1 3958
22
Sertraline Approved Phase 4,Phase 2,Phase 1 79617-96-2 68617
23
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 94-09-7, 1994-09-7 2337
24 tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
25
Lamotrigine Approved, Investigational Phase 4,Phase 3 84057-84-1 3878
26
Nicotine Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable 54-11-5 942 89594
27
Methylphenidate Approved, Investigational Phase 4,Phase 1,Early Phase 1 113-45-1 4158
28
Aripiprazole Approved, Investigational Phase 4,Phase 2,Phase 3 129722-12-9 60795
29
Memantine Approved, Investigational Phase 4,Phase 3,Phase 2 19982-08-2 4054
30
Citalopram Approved Phase 4,Phase 2,Phase 1,Not Applicable 59729-33-8 2771
31
Oxazepam Approved Phase 4 604-75-1 4616
32
Sodium oxybate Approved Phase 4 502-85-2 5360545
33 Piracetam Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 7491-74-9
34
Paroxetine Approved, Investigational Phase 4,Phase 3 61869-08-7 43815
35
Clozapine Approved Phase 4 5786-21-0 2818
36
Baclofen Approved Phase 4,Phase 2,Phase 3,Phase 1 1134-47-0 2284
37
Carbamazepine Approved, Investigational Phase 4 298-46-4 2554
38
Midazolam Approved, Illicit Phase 4,Not Applicable 59467-70-8 4192
39
Propofol Approved, Investigational, Vet_approved Phase 4,Not Applicable 2078-54-8 4943
40
Dutasteride Approved, Investigational Phase 4,Not Applicable 164656-23-9 6918296 152945
41
Icodextrin Approved, Investigational Phase 4 337376-15-5
42
Spironolactone Approved Phase 4 52-01-7, 1952-01-7 5833
43
Olanzapine Approved, Investigational Phase 4,Phase 3,Phase 2 132539-06-1 4585
44
Acetylcholine Approved Phase 4,Phase 2 51-84-3 187
45
Ribavirin Approved Phase 4,Phase 2 36791-04-5 37542
46
Methadone Approved Phase 4,Phase 2 76-99-3 4095
47
Simvastatin Approved Phase 4 79902-63-9 54454
48
Pentoxifylline Approved, Investigational Phase 4,Phase 2,Phase 3 6493-05-6 4740
49
Lenograstim Approved, Investigational Phase 4 135968-09-1
50
Chlorzoxazone Approved Phase 4,Not Applicable 95-25-0 2733

Interventional clinical trials:

(show top 50) (show all 1164)
# Name Status NCT ID Phase Drugs
1 Treatment for Alcohol Dependence With Gabapentin Unknown status NCT02771925 Phase 4 Gabapentin 2g/day divided in two doses for 24 weeks;Placebo 2g/day divided in two doses for 24 weeks
2 Safety of Acamprosate for Alcohol Dependence in the Elderly: An Open-Label Study (SAFADIE) Unknown status NCT00655967 Phase 4 Acamprosate (Campral);Acamprosate
3 Topiramate for Hospitalized Patients With Alcoholism: a 12-week Study Unknown status NCT01135602 Phase 4 Topiramate
4 Trial for the Treatment of Alcohol Dependence Unknown status NCT00120601 Phase 4 Naltrexone;Acamprosate
5 Pregabalin for Alcohol Dependence Unknown status NCT02205879 Phase 4 Pregabalin;Placebo
6 Fluoxetine and Bupropion to Treat Patients With Depression and Alcoholism Unknown status NCT00449007 Phase 4 fluoxetine;bupropion
7 Antabuse in Severe Alcoholism: an Open Controlled Study Unknown status NCT00431262 Phase 4 antabuse (disulfiram)
8 Effect of N-acetylcysteine on Alcohol and Cocaine Use Disorders: A Double-Blind Randomized Controlled Trial. Unknown status NCT03018236 Phase 4 Alcohol N-acetylcysteine;Alcohol Placebo;Cocaine N-acetylcysteine;Cocaine Placebo
9 Citicoline for Alcohol Dependence Completed NCT02074735 Phase 4 Placebo;Citicoline
10 Extended-release Naltrexone for Alcohol Dependence in Primary Care Completed NCT00620750 Phase 4 Extended release injectable naltrexone (Vivitrol)
11 Study of Campral (Acamprosate) for Alcohol Dependence in a Family Medicine Clinic Completed NCT00381043 Phase 4 Acamprosate (Campral)
12 Pharmacotherapy for Alcohol Dependence in Convicted Drinking Drivers Terminated NCT01638377 Phase 4 Naltrexone;Control
13 A Controlled Trial of Topiramate Treatment for Alcohol Dependence in Veterans With PTSD Recruiting NCT01749215 Phase 4 Topiramate;placebo
14 Study of 18 mg Selincro® As-needed Use, in the Treatment of Patients With Alcohol Dependence in Primary Care Terminated NCT02195817 Phase 4 Selincro® 18 mg with continuous psychosocial support: Cohort A
15 Zonisamide vs. Placebo in the Treatment of Alcohol Dependence Completed NCT00595556 Phase 4 zonisamide;Placebo
16 A Randomized Clinical Trial of Alcohol Care Management Completed NCT00419315 Phase 4
17 Trial of Seroquel SR for Alcohol Dependence and Comorbid Anxiety Completed NCT00352469 Phase 4 Seroquel XR
18 Disulfiram Combined With Lorazepam for Alcohol Dependence and Anxiety Disorder Completed NCT00721526 Phase 4 disulfiram plus lorazepam
19 Adjunctive Topiramate for Treatment of Alcohol Dependence in Patients With Bipolar Disorder Completed NCT00572117 Phase 4 Topiramate
20 Identifying Multiple Mechanisms of Change in Alcoholism Treatment Completed NCT01168960 Phase 4
21 Pharmacogenetic Response to Naltrexone For Alcohol Dependence Completed NCT00831272 Phase 4 naltrexone;Placebo
22 Long-Acting Injectable Naltrexone Treatment of Alcohol Dependence in Primary Care vs. in Specialized Chemical Dependence Treatment: A Pilot Trial Terminated NCT00461890 Phase 4 Injectable Naltrexone
23 Prazosin Alcohol Dependence IVR Study Completed NCT00167687 Phase 4 prazosin
24 Injectable Versus Oral Naltrexone Treatment of Alcohol Dependence In Serious Mental Illness (SMI) Completed NCT00453804 Phase 4 injectable naltrexone;oral naltrexone
25 Sertraline Pharmacotherapy for Alcoholism Subtypes Completed NCT00368550 Phase 4 Sertraline;Placebo
26 Comparative Trial Of Disulfiram, Naltrexone And Acamprosate In The Treatment Of Alcohol Dependence Completed NCT00435435 Phase 4 Disulfiram;Acamprosate;Naltexone
27 Naltrexone for Bipolar Disorder and Alcohol Dependence Completed NCT00223275 Phase 4 Naltrexone
28 Injectable Naltrexone Treatment of Alcohol Dependence in Serious Mental Illness (SMI) Completed NCT00453609 Phase 4 long-lasting injectable naltrexone
29 Treatment of Alcohol Dependence and Comorbid Bipolar Disorder Completed NCT01015586 Phase 4 Lamotrigine;Placebo
30 Genetic and Brain Mechanisms of Naltrexone's Treatment Efficacy for Alcoholism Completed NCT00920829 Phase 4 Naltrexone 50 Mg;Placebo
31 Quetiapine for Bipolar Disorder and Alcohol Dependence Completed NCT00457197 Phase 4 Placebo;Quetiapine
32 Tobacco Dependence in Alcoholism Treatment (Nicotine Patch/Naltrexone) Completed NCT00000437 Phase 4 Naltrexone Tablet and Nicotine Patch;Naltrexone Tablet and Placebo Patch;Placebo Tablet and Nicotine Patch;Placebo Tablet and Placebo Patch
33 Treatment of Patients With Alcoholism and Attention Deficit Disorder Completed NCT00261872 Phase 4 Methylphenidate
34 Managing Alcoholism in People Who Do Not Respond to Naltrexone Completed NCT00115037 Phase 4 Naltrexone;placebo
35 Behavioral Therapy Plus Naltrexone for Alcoholism Completed NCT00000456 Phase 4 naltrexone (Revia)
36 Treatment for Alcoholism and Post-Traumatic Stress Disorder (Naltrexone) Completed NCT00006489 Phase 4 Naltrexone;Placebo
37 Naltrexone Treatment for Alcoholism Completed NCT00000438 Phase 4 naltrexone (Revia)
38 Individually Adapted Therapy of Alcoholism Completed NCT00317031 Phase 4 Acamprosate or Naltrexone
39 Naltrexone Treatment of Alcohol Dependence Completed NCT00000452 Phase 4 naltrexone (Revia)
40 Sertraline for Alcohol Dependence and Depression Completed NCT00004554 Phase 4 naltrexone (Revia);sertraline (Zoloft);Placebo
41 Paliperidone Palmitate Efficacy and Safety in Bipolar Disorder Complicated by Alcoholism Withdrawn NCT01211704 Phase 4 Paliperidone Palmitate;Placebo
42 Naltrexone Maintenance Treatment of Alcoholism Completed NCT00000450 Phase 4 Naltrexone Tablet;Matched Placebo Tablet
43 Extended-Release vs. Oral Naltrexone Alcohol Treatment in Primary Care Active, not recruiting NCT01893827 Phase 4 XR-NTX (Extended-Release Naltrexone);Oral Naltrexone (O-NTX)
44 Treatment of Patients Suffering of Alcohol Dependence and Impaired Liver Function With Selincro® As-needed Use Completed NCT02197598 Phase 4 nalmefene
45 Study of Aripiprazole in Subjects With Alcoholism Completed NCT00082199 Phase 4 Aripiprazole;Placebo
46 Smoking Cessation in Alcoholism Treatment Completed NCT00000454 Phase 4 nicotine replacement patch
47 Pilot Study of Depot NTX in Homeless Veterans Terminated NCT01155869 Phase 4 Depot naltrexone;Oral Naltrexone
48 Effectiveness of Naltrexone Versus Placebo to Reduce Craving for Alcohol With Evaluation of Genetic Variability. Completed NCT00366626 Phase 4 Naltrexone;Placebo
49 Efficacy Study of Memantine Hydrochloride and Escitalopram for the Treatment of Co-Morbid Depression and Alcoholism. Completed NCT00368862 Phase 4 Ebixa (memantine hydrochloride);Cipralex (escitalopram)
50 Acamprosate in Alcoholics With Comorbid Anxiety or Depression Completed NCT00330174 Phase 4 Acamprosate

Search NIH Clinical Center for Alcohol Dependence

Inferred drug relations via UMLS 73 / NDF-RT 51 :
Sources

Genetic Tests for Alcohol Dependence

About this section

Genetic tests related to Alcohol Dependence:

# Genetic test Affiliating Genes
1 Alcohol Dependence 29 ADH1B ADH1C GABRA2 HTR2A
Sources

Anatomical Context for Alcohol Dependence

About this section

MalaCards organs/tissues related to Alcohol Dependence:

41
Brain, Testes, Liver, Cortex, Amygdala, Prefrontal Cortex, Lung
Sources

Publications for Alcohol Dependence

About this section

Articles related to Alcohol Dependence:

(show top 50) (show all 2085)
# Title Authors Year
1
Epidemiology of Alcohol Consumption and Societal Burden of Alcoholism and Alcoholic Liver Disease. ( 30454831 )
2019
2
Introduction: Alcohol and Alcoholism. ( 30454824 )
2019
3
Treatment of alcohol dependence. Alcohol and homelessness: social point of view. ( 29912211 )
2018
4
Is family history of alcohol dependence a risk factor for disturbed sleep in alcohol dependent subjects? ( 29843109 )
2018
5
Corneal endothelial alterations in alcohol dependence syndrome. ( 29305345 )
2018
6
Prevalence Estimates of ADHD in a Sample of Inpatients With Alcohol Dependence. ( 29308693 )
2018
7
Short message service (SMS) reminders improve treatment attendance in alcohol dependence, but are less effective for patients high in impulsivity. ( 29975880 )
2018
8
Italian Guidelines for the treatment of alcohol dependence. ( 29912210 )
2018
9
Religiosity, Guilt, Altruism and Forgiveness in Alcohol Dependence: Results of a Cross-sectional and Prospective Cohort Study. ( 29912267 )
2018
10
Lack of association between MTHFR C677T Gene polymorphism with alcohol dependence: A meta-analysis of case-control studies. ( 29953924 )
2018
11
Self-defining memories related to alcohol dependence and their integration in the construction of the self in a sample of abstinent alcoholics. ( 29944064 )
2018
12
The need for precise answers for the goals of precision medicine in alcohol dependence to succeed. ( 29930386 )
2018
13
Treatment of alcohol dependence. Alcohol and the young: social point of view. ( 29912212 )
2018
14
Dialectical Behavior Therapy Skills Training in Alcohol Dependence Treatment: Findings Based on an Open Trial. ( 29958050 )
2018
15
Association of alcohol dehydrogenase 1C gene *1/*2 polymorphism with alcohol Dependence(AD) in Turkey: A meta-analysis. ( 29438797 )
2018
16
Predictors of Utilization of an Addiction-Specific Behavioural Couple Therapy in Alcohol Dependence. ( 29902784 )
2018
17
How do people with homelessness and alcohol dependence cope when alcohol is unaffordable? A comparison of residents of Canadian managed alcohol programs and locally recruited controls. ( 29314309 )
2018
18
Effects of alcohol dependence on discrete choice between alcohol and saccharin. ( 29875449 )
2018
19
Effect of electronic brief intervention on uptake of specialty treatment in hospital outpatients with likely alcohol dependence: Pilot randomized trial and qualitative interviews. ( 29306817 )
2018
20
Efficacy, tolerability, and safety of low-dose and high-dose baclofen in the treatment of alcohol dependence: A systematic review and meta-analysis. ( 29934090 )
2018
21
Mecamylamine treatment for alcohol dependence: a randomized controlled trial. ( 28710873 )
2018
22
Effect of Interaction Between Duration of Alcohol Consumption and Alcohol Dependence on Thyroid Function Test: Cross Sectional Observational Study. ( 29371771 )
2018
23
Sex differences in the ACTH and cortisol response to pharmacological probes are stressor-specific and occur regardless of alcohol dependence history. ( 29763783 )
2018
24
Response to Letter to Editor (Precision medicine in alcohol dependence: evidence of efficacy and initial support for comparative effectiveness). ( 29930387 )
2018
25
Impulsive Personality Traits Mediate the Relationship Between Adult Attention-Deficit/Hyperactivity Symptoms and Alcohol Dependence Severity. ( 29063627 )
2018
26
Repetitive transcranial magnetic stimulation (rTMS) in alcohol dependence: study protocol of a randomized controlled clinical trial of efficacy and working mechanisms. ( 29866086 )
2018
27
Influence of Parental Alcohol Dependence Symptoms and Parenting on Adolescent Risky Drinking and Conduct Problems: A Family Systems Perspective. ( 29969154 )
2018
28
The Speed of Progression to Tobacco and Alcohol Dependence: A Twin Study. ( 29427143 )
2018
29
Treatment for Alcohol Dependence in Primary Care Compared to Outpatient Specialist Treatment-A Randomized Controlled Trial. ( 29346473 )
2018
30
Decoding diagnosis and lifetime consumption in alcohol dependence from grey-matter pattern information. ( 29377059 )
2018
31
Shared genetic etiology between alcohol dependence and major depressive disorder. ( 29901528 )
2018
32
Automatic visual-spatial perspective taking in alcohol-dependence: A study with happy emotional faces. ( 29966852 )
2018
33
Activation of neural stem cells from quiescence drives reactive hippocampal neurogenesis after alcohol dependence. ( 29378214 )
2018
34
Lower limbic metabotropic glutamate receptor 5 availability in alcohol dependence. ( 29348321 )
2018
35
Nicotine-Use/Smoking Is Associated with the Efficacy of Naltrexone in the Treatment of Alcohol Dependence. ( 29431852 )
2018
36
A Call to Action for Treatment of Comorbid Tobacco and Alcohol Dependence. ( 29261821 )
2018
37
Intangible costs of alcohol dependence from the perspective of patients and their relatives: A contingent valuation study. ( 27749972 )
2018
38
Female-male differences in alcohol dependence levels: Evidence on newly incident adolescent and young-adult drinkers in the United States, 2002-2014. ( 29745044 )
2018
39
Imaging resilience and recovery in alcohol dependence. ( 29744956 )
2018
40
Prevalence and correlates of sexual dysfunction in male patients with alcohol dependence syndrome: A cross-sectional study. ( 29736066 )
2018
41
Deficient inhibition in alcohol-dependence: let's consider the role of the motor system! ( 29728650 )
2018
42
Baclofen in the treatment of alcohol dependence with or without liver disease: multisite, randomised, double-blind, placebo-controlled trial. ( 29716670 )
2018
43
Antidepressants for the treatment of people with co-occurring depression and alcohol dependence. ( 29688573 )
2018
44
Association of serotonin and GABA pathway gene polymorphisms with alcohol dependence: A preliminary study. ( 29673739 )
2018
45
Add-On Memantine Treatment for Bipolar II Disorder Comorbid with Alcohol Dependence: A 12-Week Follow-Up Study. ( 29656414 )
2018
46
Abnormal gray matter asymmetry in alcohol dependence. ( 29629981 )
2018
47
Random forest based classification of alcohol dependence patients and healthy controls using resting state MRI. ( 29626649 )
2018
48
Aberrant regional brain activities in alcohol dependence: a functional magnetic resonance imaging study. ( 29606878 )
2018
49
No association of CYP2E1 genetic polymorphisms with alcohol dependence in Han Taiwanese population. ( 29588096 )
2018
50
Attempts to reduce alcohol intake and treatment needs among people with probable alcohol dependence in England: a general population survey. ( 29575560 )
2018