MCID: ALC001
MIFTS: 32

Alcohol-Related Birth Defect

Categories: Mental diseases, Fetal diseases

Aliases & Classifications for Alcohol-Related Birth Defect

MalaCards integrated aliases for Alcohol-Related Birth Defect:

Name: Alcohol-Related Birth Defect 12 15
Alcohol Related Birth Defect 73
Fetal Alcohol Syndrome 73
Arbd 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050668

Summaries for Alcohol-Related Birth Defect

Disease Ontology : 12 A fetal alcohol spectrum disorder that results in damage to organs, bones, or muscles due to prenatal alcohol exposure.

MalaCards based summary : Alcohol-Related Birth Defect, also known as alcohol related birth defect, is related to fetal alcohol syndrome and fetal alcohol spectrum disorder. An important gene associated with Alcohol-Related Birth Defect is SV2C (Synaptic Vesicle Glycoprotein 2C), and among its related pathways/superpathways are Collagen chain trimerization and Formation of Fibrin Clot (Clotting Cascade). The drugs Ethanol and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotypes are behavior/neurological and mortality/aging

Wikipedia : 76 Fetal alcohol spectrum disorders (FASDs) are a group of conditions that can occur in a person whose... more...

Related Diseases for Alcohol-Related Birth Defect

Diseases related to Alcohol-Related Birth Defect via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 fetal alcohol syndrome 12.1
2 fetal alcohol spectrum disorder 11.8
3 acquired von willebrand syndrome 10.4 F11 F8
4 foodborne botulism 10.3 GP2 SNAP25 SV2C
5 lemierre's syndrome 10.2 F11 F3
6 intracranial thrombosis 10.0 F3 F8
7 multicentric castleman disease 10.0 F3 F8
8 factor xiii deficiency 10.0 F3 F8
9 vitamin k deficiency hemorrhagic disease 9.8 F2 F8
10 retinal artery occlusion 9.8 F2 F8
11 cardiac tamponade 9.8 F2 F8
12 hepatic veno-occlusive disease 9.8 F3 F8
13 thrombophlebitis 9.8 F2 F8
14 cerebral falx meningioma 9.7 F2 F3
15 intestinal impaction 9.7 F2 F3
16 post-thrombotic syndrome 9.7 F2 F8
17 cerebral sinovenous thrombosis 9.7 F2 F3
18 leech infestation 9.7 F2 F3
19 giant hemangioma 9.7 F2 F3
20 sagittal sinus thrombosis 9.7 F2 F3
21 blue toe syndrome 9.7 F2 F3
22 intracranial embolism 9.7 F2 F3
23 femoral neuropathy 9.7 F2 F3
24 acquired hemophilia a 9.7 F11 F3 F8
25 acquired hemophilia 9.7 F11 F3 F8
26 compartment syndrome 9.7 F2 F8
27 hantavirus pulmonary syndrome 9.7 F2 F3
28 anterior cranial fossa meningioma 9.7 F2 F3
29 splenic disease 9.7 F2 F3
30 hemophilia a 9.7 F11 F3 F8
31 marantic endocarditis 9.7 F2 F3
32 retinitis pigmentosa, y-linked 9.7 F2 WDTC1
33 purpura fulminans 9.7 F2 F3
34 korean hemorrhagic fever 9.7 F2 F3
35 hepatic infarction 9.6 F2 F3
36 peripheral vertigo 9.6 F2 F3
37 hemorrhagic fever 9.6 F2 F3
38 endocardium disease 9.5 F2 F3
39 analbuminemia 9.5 F2 F3
40 hepatic vascular disease 9.5 F2 F3
41 squamous cell papilloma 9.5 F2 F3
42 protein s deficiency 9.5 F2 F3
43 factor viii deficiency 9.5 F11 F2 F8
44 thrombasthenia 9.4 F2 F3
45 intracranial hypertension 9.4 F2 F3
46 factor xi deficiency 9.3 F11 F2 F3
47 factor x deficiency 9.3 F11 F2 F3
48 hepatitis a 9.3 F2 F3
49 dengue hemorrhagic fever 9.2 F2 F3
50 fournier gangrene 9.2 F2 F3 F8

Graphical network of the top 20 diseases related to Alcohol-Related Birth Defect:



Diseases related to Alcohol-Related Birth Defect

Symptoms & Phenotypes for Alcohol-Related Birth Defect

MGI Mouse Phenotypes related to Alcohol-Related Birth Defect:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.8 F2 F3 FGFR3 SNAP25 SV2A SV2C
2 mortality/aging MP:0010768 9.76 F2 F3 F8 FGFR3 SNAP25 SV2A
3 normal MP:0002873 9.43 F2 F3 FGFR3 GP2 SNAP25 SV2A
4 respiratory system MP:0005388 9.02 F2 F3 FGFR3 SNAP25 F11

Drugs & Therapeutics for Alcohol-Related Birth Defect

Drugs for Alcohol-Related Birth Defect (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Not Applicable 64-17-5 702
2 Anti-Infective Agents Not Applicable
3 Anti-Infective Agents, Local Not Applicable
4 Central Nervous System Depressants Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Reducing Alcohol Exposed Pregnancy Risk: EARLY Randomized Controlled Trial Completed NCT01446653 Not Applicable

Search NIH Clinical Center for Alcohol-Related Birth Defect

Genetic Tests for Alcohol-Related Birth Defect

Anatomical Context for Alcohol-Related Birth Defect

MalaCards organs/tissues related to Alcohol-Related Birth Defect:

41
Bone

Publications for Alcohol-Related Birth Defect

Articles related to Alcohol-Related Birth Defect:

# Title Authors Year
1
ADH2 and CYP2E1 genetic polymorphisms: risk factors for alcohol-related birth defects. ( 11259352 )
2001
2
A multiple-level, comprehensive approach to the prevention of fetal alcohol syndrome (FAS) and other alcohol-related birth defects (ARBD). ( 8557409 )
1995

Variations for Alcohol-Related Birth Defect

Expression for Alcohol-Related Birth Defect

Search GEO for disease gene expression data for Alcohol-Related Birth Defect.

Pathways for Alcohol-Related Birth Defect

Pathways related to Alcohol-Related Birth Defect according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.34 F11 F2 F3 F8
2
Show member pathways
11.46 F11 F2 F3 F8
3
Show member pathways
11.23 SNAP25 SV2A SV2C
4 11.07 F11 F2 F3 F8
5
Show member pathways
10.26 SV2A SV2C

GO Terms for Alcohol-Related Birth Defect

Cellular components related to Alcohol-Related Birth Defect according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.63 F11 F2 F3 F8 FGFR3 GP2
2 plasma membrane GO:0005886 9.61 F11 F2 F3 F8 FGFR3 GP2
3 synaptic vesicle GO:0008021 8.8 SNAP25 SV2A SV2C

Biological processes related to Alcohol-Related Birth Defect according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemical synaptic transmission GO:0007268 9.58 SNAP25 SV2A SV2C
2 blood coagulation GO:0007596 9.46 F11 F2 F3 F8
3 neurotransmitter transport GO:0006836 9.37 SV2A SV2C
4 acute-phase response GO:0006953 9.32 F2 F8
5 regulation of blood coagulation GO:0030193 9.26 F11 F2
6 blood coagulation, intrinsic pathway GO:0007597 9.13 F11 F2 F8
7 hemostasis GO:0007599 8.92 F11 F2 F3 F8

Molecular functions related to Alcohol-Related Birth Defect according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 8.8 F11 F2 F3

Sources for Alcohol-Related Birth Defect

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....