ARBD
MCID: ALC001
MIFTS: 45

Alcohol-Related Birth Defect (ARBD)

Categories: Fetal diseases, Mental diseases

Aliases & Classifications for Alcohol-Related Birth Defect

MalaCards integrated aliases for Alcohol-Related Birth Defect:

Name: Alcohol-Related Birth Defect 12 15
Alcohol Related Birth Defect 73
Fetal Alcohol Syndrome 73
Arbd 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050668

Summaries for Alcohol-Related Birth Defect

Disease Ontology : 12 A fetal alcohol spectrum disorder that results in damage to organs, bones, or muscles due to prenatal alcohol exposure.

MalaCards based summary : Alcohol-Related Birth Defect, also known as alcohol related birth defect, is related to fetal alcohol syndrome and fetal alcohol spectrum disorder. An important gene associated with Alcohol-Related Birth Defect is SV2C (Synaptic Vesicle Glycoprotein 2C), and among its related pathways/superpathways are Collagen chain trimerization and Formation of Fibrin Clot (Clotting Cascade). The drugs Ethanol and Anti-Infective Agents, Local have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and eye, and related phenotypes are behavior/neurological and mortality/aging

Wikipedia : 76 Fetal alcohol spectrum disorders (FASDs) are a group of conditions that can occur in a person whose... more...

Related Diseases for Alcohol-Related Birth Defect

Diseases related to Alcohol-Related Birth Defect via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Related Disease Score Top Affiliating Genes
1 fetal alcohol syndrome 12.3
2 fetal alcohol spectrum disorder 12.0
3 acquired von willebrand syndrome 10.1 F11 F8
4 foodborne botulism 10.1 GP2 SNAP25 SV2C
5 lemierre's syndrome 10.0 F11 F3
6 factor xiii deficiency 10.0 F3 F8
7 intracranial thrombosis 10.0 F3 F8
8 retinal artery occlusion 10.0 F2 F8
9 brachydactyly, type d 9.9 F2 F8
10 vitamin k deficiency hemorrhagic disease 9.9 F2 F8
11 cardiac tamponade 9.9 F2 F8
12 von willebrand disease, type 2 9.9 F3 F8
13 livedoid vasculitis 9.9 F2 F8
14 thrombophlebitis 9.9 F2 F8
15 post-thrombotic syndrome 9.9 F2 F8
16 thrombasthenia 9.9 F2 F3
17 cerebral falx meningioma 9.9 F2 F3
18 leech infestation 9.9 F2 F3
19 prothrombin deficiency 9.9 F2 F3
20 intestinal impaction 9.9 F2 F3
21 cerebral sinovenous thrombosis 9.9 F2 F3
22 giant hemangioma 9.9 F2 F3
23 sagittal sinus thrombosis 9.9 F2 F3
24 blue toe syndrome 9.9 F2 F3
25 femoral neuropathy 9.9 F2 F3
26 acquired hemophilia 9.9 F11 F3 F8
27 acquired hemophilia a 9.9 F11 F3 F8
28 hemophilia a 9.9 F11 F3 F8
29 hantavirus pulmonary syndrome 9.9 F2 F3
30 anterior cranial fossa meningioma 9.9 F2 F3
31 compartment syndrome 9.9 F2 F8
32 korean hemorrhagic fever 9.9 F2 F3
33 hemorrhagic fever 9.9 F2 F3
34 marantic endocarditis 9.9 F2 F3
35 von willebrand disease, type 3 9.9 F11 F3 F8
36 vascular hemostatic disease 9.9 F2 F3
37 splenic disease 9.9 F2 F3
38 retinitis pigmentosa, y-linked 9.9 F2 WDTC1
39 purpura fulminans 9.9 F2 F3
40 hepatic infarction 9.9 F2 F3
41 peripheral vertigo 9.9 F2 F3
42 blood protein disease 9.9 F2 F3
43 endocardium disease 9.9 F2 F3
44 analbuminemia 9.9 F2 F3
45 hepatic vascular disease 9.8 F2 F3
46 pulmonary artery disease 9.8 F2 F3
47 squamous cell papilloma 9.8 F2 F3
48 factor viii deficiency 9.8 F11 F2 F8
49 protein s deficiency 9.8 F2 F3
50 intracranial hypertension 9.8 F2 F3

Graphical network of the top 20 diseases related to Alcohol-Related Birth Defect:



Diseases related to Alcohol-Related Birth Defect

Symptoms & Phenotypes for Alcohol-Related Birth Defect

MGI Mouse Phenotypes related to Alcohol-Related Birth Defect:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.8 F11 F2 F3 FGFR3 SNAP25 SV2A
2 mortality/aging MP:0010768 9.76 F11 F2 F3 F8 FGFR3 SNAP25
3 normal MP:0002873 9.43 F2 F3 FGFR3 GP2 SNAP25 SV2A
4 respiratory system MP:0005388 9.02 F11 F2 F3 FGFR3 SNAP25

Drugs & Therapeutics for Alcohol-Related Birth Defect

Drugs for Alcohol-Related Birth Defect (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Not Applicable 64-17-5 702
2 Anti-Infective Agents, Local Not Applicable
3 Anti-Infective Agents Not Applicable
4 Central Nervous System Depressants Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Reducing Alcohol Exposed Pregnancy Risk: EARLY Randomized Controlled Trial Completed NCT01446653 Not Applicable

Search NIH Clinical Center for Alcohol-Related Birth Defect

Genetic Tests for Alcohol-Related Birth Defect

Anatomical Context for Alcohol-Related Birth Defect

MalaCards organs/tissues related to Alcohol-Related Birth Defect:

41
Bone, Brain, Eye, Liver, Fetal Brain, Testes, Cortex

Publications for Alcohol-Related Birth Defect

Articles related to Alcohol-Related Birth Defect:

(show top 50) (show all 840)
# Title Authors Year
1
Recognition of clinical characteristics for population-based surveillance of fetal alcohol syndrome. ( 29368410 )
2018
2
Genetic predisposition to fetal alcohol syndrome: association with congenital disorders of N-glycosylation. ( 28820871 )
2018
3
Effects of ethanol and varenicline on female Sprague-Dawley rats in a third trimester model of fetal alcohol syndrome. ( 30059955 )
2018
4
Atypical fetal development: Fetal alcohol syndrome, nutritional deprivation, teratogens, and risk for neurodevelopmental disorders and psychopathology. ( 30068419 )
2018
5
Comparing diagnostic outcomes of children with fetal alcohol syndrome in South Africa with diagnostic outcomes when using the updated Institute of Medicine diagnostic guidelines. ( 30347134 )
2018
6
<i>Xenopus</i> embryos to study Fetal Alcohol Syndrome, a model for environmental teratogenesis. ( 29069552 )
2017
7
Fetal Alcohol Syndrome and Fetal Alcohol Spectrum Disorders. ( 29094891 )
2017
8
Differences in neural crest sensitivity to ethanol account for the infrequency of anterior segment defects in the eye compared with craniofacial anomalies in a zebrafish model of fetal alcohol syndrome. ( 28681995 )
2017
9
Unreliable estimation of prevalence of fetal alcohol syndrome. ( 28495259 )
2017
10
Unreliable estimation of prevalence of fetal alcohol syndrome. ( 28495260 )
2017
11
Unreliable estimation of prevalence of fetal alcohol syndrome - Authors' reply. ( 28495261 )
2017
12
Estimation of national, regional, and global prevalence of alcohol use during pregnancy and fetal alcohol syndrome: a systematic review and meta-analysis. ( 28089487 )
2017
13
Competition between ethanol clearance and retinoic acid biosynthesis in the induction of Fetal Alcohol Syndrome. ( 28982012 )
2017
14
Digital assessment of the fetal alcohol syndrome facial phenotype: reliability and agreement study. ( 29637153 )
2017
15
The Prevalence of Fetal Alcohol Syndrome and Its Impact on a Child's Classroom Performance: A Case Study of a Rural South African School. ( 28792446 )
2017
16
Fetal Alcohol Syndrome Disorder: diminished responsibility and mitigation of sentence. ( 28699765 )
2017
17
A Rat Model of Fetal Alcohol Syndrome: A Series of Undergraduate Laboratory Exercises for Biopsychology Courses. ( 28690436 )
2017
18
Fetal Alcohol Syndrome ( 28846263 )
2017
19
High global prevalence of alcohol use during pregnancy and fetal alcohol syndrome indicates need for urgent action. ( 28089488 )
2017
20
Societal costs of fetal alcohol syndrome in Sweden. ( 27279344 )
2016
21
An Update on Fetal Alcohol Syndrome-Pathogenesis, Risks, and Treatment. ( 27375266 )
2016
22
Magnetic resonance imaging (MRI) findings among children with fetal alcohol syndrome (FAS), partial fetal alcohol syndrome (pFAS) and alcohol related neurodevelopmental disorders (ARND). ( 29688653 )
2016
23
Life Expectancy of People with Fetal Alcohol Syndrome. ( 26962962 )
2016
24
Changes in drinking patterns during and after pregnancy among mothers of children with fetal alcohol syndrome: A study in three districts of South Africa. ( 27610936 )
2016
25
Pattern of Retinal Nerve Fiber Layer Thickness Loss in Fetal Alcohol Syndrome: A Spectral-Domain Optical Coherence Tomography Analysis. ( 27349777 )
2016
26
Modeling Symptoms of Attention-Deficit Hyperactivity Disorder in a Rat Model of Fetal Alcohol Syndrome. ( 27117236 )
2016
27
Fetal Alcohol Syndrome and Maternal Alcohol Biomarkers in Sera: A Register-Based Case-Control Study. ( 27228551 )
2016
28
Fetal Alcohol Syndrome in Sudden Unexpected Death in Infancy: A Case Report in Medicolegal Autopsy. ( 26730801 )
2016
29
Childhood placement in out-of-home care in relation to psychosocial outcomes in adults with fetal alcohol syndrome. ( 27371665 )
2016
30
Mental and Motor Development of Children with Preterm Birth and Children with Fetal Alcohol Syndrome. ( 26038965 )
2015
31
Reduced DNA methylation at the PEG3 DMR and KvDMR1 loci in children exposed to alcohol in utero: a South African Fetal Alcohol Syndrome cohort study. ( 25806045 )
2015
32
Fetal alcohol syndrome among children aged 7-9 years - Arizona, Colorado, and New York, 2010. ( 25632951 )
2015
33
Psychosocial outcomes of fetal alcohol syndrome in adulthood. ( 25535260 )
2015
34
Dose-dependent alcohol-induced alterations in chromatin structure persist beyond the window of exposure and correlate with fetal alcohol syndrome birth defects. ( 26421061 )
2015
35
Methods for surveillance of fetal alcohol syndrome: The fetal alcohol syndrome surveillance network II (FASSNetII) - Arizona, Colorado, New York, 2009 - 2014. ( 25761572 )
2015
36
Cognitive and executive functions, social cognition and sense of coherence in adults with fetal alcohol syndrome. ( 25697067 )
2015
37
A transition in fetal alcohol syndrome research: the shift from animal modeling to human intervention. ( 25614482 )
2015
38
Prevalence and characteristics of fetal alcohol syndrome and partial fetal alcohol syndrome in a Rocky Mountain Region City. ( 26321671 )
2015
39
Prevalence of fetal alcohol syndrome in a South African city with a predominantly Black African population. ( 25941030 )
2015
40
Prevalence of fetal alcohol syndrome in a population-based sample of children living in remote Australia: The Lililwan Project. ( 25594247 )
2015
41
Fetal alcohol syndrome and secondary schizophrenia: a unique neuropathologic study. ( 24563476 )
2015
42
Effect of boric acid on oxidative stress in rats with fetal alcohol syndrome. ( 25667671 )
2015
43
Ethanol-induced impairment of polyamine homeostasis--a potential cause of neural tube defect and intrauterine growth restriction in fetal alcohol syndrome. ( 24582559 )
2014
44
Habilitational treatment of a child with fetal alcohol syndrome: case report. ( 24974670 )
2014
45
Renal dysfunction in fetal alcohol syndrome: a potential contributor on developmental disabilities of offspring. ( 25610884 )
2014
46
Neural crest development in fetal alcohol syndrome. ( 25219761 )
2014
47
Fetal alcohol syndrome, chemo-biology and OMICS: ethanol effects on vitamin metabolism during neurodevelopment as measured by systems biology analysis. ( 24816220 )
2014
48
Brainstem Disconnection in a Late Preterm Neonate With Classic Features of Fetal Alcohol Syndrome. ( 25152965 )
2014
49
Fetal alcohol syndrome (FAS) and fetal alcohol spectrum disorder (FASD)-diagnosis and moral policing; an ethical dilemma for paediatricians. ( 25005521 )
2014
50
Fetal alcohol syndrome surveillance: age of syndrome manifestation in case ascertainment. ( 24737611 )
2014

Variations for Alcohol-Related Birth Defect

Expression for Alcohol-Related Birth Defect

Search GEO for disease gene expression data for Alcohol-Related Birth Defect.

Pathways for Alcohol-Related Birth Defect

Pathways related to Alcohol-Related Birth Defect according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.34 F11 F2 F3 F8
2
Show member pathways
11.46 F11 F2 F3 F8
3
Show member pathways
11.23 SNAP25 SV2A SV2C
4 11.07 F11 F2 F3 F8
5
Show member pathways
10.26 SV2A SV2C

GO Terms for Alcohol-Related Birth Defect

Cellular components related to Alcohol-Related Birth Defect according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 F11 F2 F3 F8 FGFR3 GP2
2 plasma membrane GO:0005886 9.28 F11 F2 F3 F8 FGFR3 GP2
3 integral component of synaptic vesicle membrane GO:0030285 9.16 SV2A SV2C
4 synaptic vesicle GO:0008021 9.13 SNAP25 SV2A SV2C

Biological processes related to Alcohol-Related Birth Defect according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemical synaptic transmission GO:0007268 9.58 SNAP25 SV2A SV2C
2 blood coagulation GO:0007596 9.46 F11 F2 F3 F8
3 neurotransmitter transport GO:0006836 9.43 SV2A SV2C
4 acute-phase response GO:0006953 9.37 F2 F8
5 synaptic vesicle priming GO:0016082 9.32 SNAP25 SV2A
6 regulation of blood coagulation GO:0030193 9.26 F11 F2
7 blood coagulation, intrinsic pathway GO:0007597 9.13 F11 F2 F8
8 hemostasis GO:0007599 8.92 F11 F2 F3 F8

Molecular functions related to Alcohol-Related Birth Defect according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 8.8 F11 F2 F3

Sources for Alcohol-Related Birth Defect

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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