ARND
MCID: ALC002
MIFTS: 30

Alcohol-Related Neurodevelopmental Disorder (ARND)

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Alcohol-Related Neurodevelopmental Disorder

MalaCards integrated aliases for Alcohol-Related Neurodevelopmental Disorder:

Name: Alcohol-Related Neurodevelopmental Disorder 12 15
Static Encephalopathy 12 70
Alcohol Related Neurodevelopmental Disorder 70
Arnd 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050667
UMLS 70 C0814154 C3662068

Summaries for Alcohol-Related Neurodevelopmental Disorder

Disease Ontology : 12 A fetal alcohol spectrum disorder that results in central nervous system dysfunction and behavioral and/or cognitive deficits due to prenatal alcohol exposure.

MalaCards based summary : Alcohol-Related Neurodevelopmental Disorder, also known as static encephalopathy, is related to fetal alcohol spectrum disorder and neurodegeneration with brain iron accumulation 5. An important gene associated with Alcohol-Related Neurodevelopmental Disorder is WDR45 (WD Repeat Domain 45). The drug Ethanol has been mentioned in the context of this disorder. Affiliated tissues include brain and eye, and related phenotype is mortality/aging.

Related Diseases for Alcohol-Related Neurodevelopmental Disorder

Diseases related to Alcohol-Related Neurodevelopmental Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 fetal alcohol spectrum disorder 32.2 WDR45 MECP2 GRIN2B FAM24A
2 neurodegeneration with brain iron accumulation 5 32.0 WIPI2 WDR45 SNX14 EPG5 C19orf12
3 neurodegeneration with brain iron accumulation 1 29.9 WDR45 C19orf12
4 neurodegeneration with brain iron accumulation 29.7 WDR45 SNX14 EPG5 C19orf12
5 dystonia 29.3 WDR45 MECP2 GRIN2B COX20 C19orf12
6 fetal alcohol syndrome 11.7
7 leukoencephalopathy, cystic, without megalencephaly 11.0
8 mecp2-related severe neonatal encephalopathy 11.0
9 encephalopathy 10.5
10 alcohol-related birth defect 10.4
11 acrocephalopolysyndactyly type iii 10.3 WDR45 C19orf12
12 neurodegeneration with brain iron accumulation 4 10.3 WDR45 C19orf12
13 neurodegeneration with brain iron accumulation 6 10.2 WDR45 C19orf12
14 neurodegeneration with brain iron accumulation 3 10.2 WDR45 C19orf12
15 cecum adenocarcinoma 10.2 RIOK2 RIOK1
16 neurodegeneration with brain iron accumulation 2a 10.2 WDR45 C19orf12
17 spastic paraplegia 35, autosomal recessive 10.2 WDR45 C19orf12
18 landau-kleffner syndrome 10.1 MECP2 GRIN2B
19 cecum carcinoma 10.1 RIOK2 RIOK1
20 kufor-rakeb syndrome 10.1 WDR45 C19orf12
21 cerebral palsy 10.1
22 hand skill, relative 10.0
23 attention deficit-hyperactivity disorder 10.0
24 agenesis of corpus callosum, cardiac, ocular, and genital syndrome 10.0
25 cohen syndrome 10.0 SNX14 MECP2 GRIN2B
26 ataxia and polyneuropathy, adult-onset 10.0
27 quadriplegia 10.0
28 hypotonia 10.0
29 pervasive developmental disorder 10.0 MECP2 KPTN GRIN2B
30 partial fetal alcohol syndrome 9.9
31 spastic paraplegia 49, autosomal recessive 9.9 WDR45 SNX14 EPG5
32 spinocerebellar ataxia, autosomal recessive 20 9.9 WDR45 SNX14 EPG5
33 vici syndrome 9.9 WDR45 SNX14 EPG5
34 3-methylglutaconic aciduria, type iii 9.8
35 cerebral creatine deficiency syndrome 1 9.8
36 encephalopathy due to defective mitochondrial and peroxisomal fission 1 9.8
37 metabolic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration 9.8
38 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 9.8
39 scoliosis 9.8
40 myoglobinuria 9.8
41 parkinsonism 9.8
42 hemiplegia 9.8
43 movement disease 9.8
44 axonal neuropathy 9.8
45 neuropathy 9.8
46 pathologic nystagmus 9.8
47 toxocariasis 9.8
48 creatine deficiency syndromes 9.8
49 hip subluxation 9.8
50 anoxia 9.8

Graphical network of the top 20 diseases related to Alcohol-Related Neurodevelopmental Disorder:



Diseases related to Alcohol-Related Neurodevelopmental Disorder

Symptoms & Phenotypes for Alcohol-Related Neurodevelopmental Disorder

MGI Mouse Phenotypes related to Alcohol-Related Neurodevelopmental Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.4 ALDH5A1 AMPD2 COX20 EPG5 GRIN2B MECP2

Drugs & Therapeutics for Alcohol-Related Neurodevelopmental Disorder

Drugs for Alcohol-Related Neurodevelopmental Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 1, Phase 2 64-17-5 702

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Intervening With Children/Adolescents With FAS/ARND Completed NCT00164528 Phase 1, Phase 2
2 Fetal Alcohol Syndrome/ARND Research Consortion-Oklahoma Completed NCT00164554 Phase 1, Phase 2
3 Neurocognitive Habilitation for Children With FAS/ARND Completed NCT00164346 Phase 1, Phase 2
4 Effectiveness of Visual and Auditory Feedback on Eye-hand Coordination in Children With Hemiplegic Cerebral Palsy Unknown status NCT03742999
5 Optic Nerve Head Morphology in Children With Perinatal Onset Static Encephalopathy Completed NCT00769197
6 Augmented Biofeedback Training Combined With Physical Therapy Program Improves Visual-motor Integration, Visual Perception and Motor Coordination in Children With Spastic Hemiplegic Cerebral Palsy: a Randomized Control Trial Completed NCT03626077
7 Preventing FAS/ARND in Russian Children/Expansion to Interdisciplinary HIV Prevention in Women Completed NCT01994603
8 Preventing FAS/ARND in Russian Children Completed NCT01961050

Search NIH Clinical Center for Alcohol-Related Neurodevelopmental Disorder

Genetic Tests for Alcohol-Related Neurodevelopmental Disorder

Anatomical Context for Alcohol-Related Neurodevelopmental Disorder

MalaCards organs/tissues related to Alcohol-Related Neurodevelopmental Disorder:

40
Brain, Eye

Publications for Alcohol-Related Neurodevelopmental Disorder

Articles related to Alcohol-Related Neurodevelopmental Disorder:

(show top 50) (show all 230)
# Title Authors PMID Year
1
Beta-propeller protein-associated neurodegeneration presenting Rett-like features: A case report and literature review. 61
33251766 2021
2
Infant Cardiac Orienting Responses Predict Later FASD in the Preschool Period. 61
33277942 2021
3
A Validation Study of the Alcohol Related Neurodevelopmental Disorders Behavioral Checklist. 61
33583035 2021
4
Prevalence of Fetal Alcohol Spectrum Disorders (FASD) among Children Adopted from Eastern European Countries: Russia and Ukraine. 61
33546212 2021
5
Residual lumbar hyperlordosis is associated with worsened hip status 5 years after scoliosis correction in non-ambulant patients with cerebral palsy. 61
33523455 2021
6
Altered Resting-State Neural Oscillations and Spectral Power in Children with Fetal Alcohol Spectrum Disorder. 61
33164218 2021
7
The prevalence, child characteristics, and maternal risk factors for the continuum of fetal alcohol spectrum disorders: A sixth population-based study in the same South African community. 61
33250379 2021
8
[Fetal alcohol spectrum disorders in adults]. 61
33104818 2020
9
Midstance hamstring length is a better indicator for hamstring lengthening procedures than initial contact length. 61
32485420 2020
10
Pathogenic variants in KPTN gene identified by clinical whole-genome sequencing. 61
32358097 2020
11
Characterizing Alcohol-Related Neurodevelopmental Disorder: Prenatal Alcohol Exposure and the Spectrum of Outcomes. 61
32173870 2020
12
Incontinence in persons with fetal alcohol spectrum disorders: a polish cohort. 61
32222270 2020
13
Fetal alcohol spectrum disorder among pre-adopted and foster children. 61
32493264 2020
14
Fetal Alcohol Spectrum Disorders in a Midwestern City: Child Characteristics, Maternal Risk Traits, and Prevalence. 61
32293735 2020
15
Four-year follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder. 61
32164522 2020
16
Fetal Alcohol Spectrum Disorders in a Pacific Southwest City: Maternal and Child Characteristics. 61
31688971 2019
17
Is WDR45 the missing link for ER stress-induced autophagy in beta-propeller associated neurodegeneration? 61
31525124 2019
18
New-onset lesional and nonlesional epilepsy in the US population: Patient characteristics and patterns of antiepileptic drug use. 61
31605878 2019
19
Observation of novel COX20 mutations related to autosomal recessive axonal neuropathy and static encephalopathy. 61
31079202 2019
20
Relationship of muscle morphology to hip displacement in cerebral palsy: a pilot study investigating changes intrinsic to the sarcomere. 61
31227002 2019
21
De novo missense variant in the GTPase effector domain (GED) of DNM1L leads to static encephalopathy and seizures. 61
30850373 2019
22
Foam Padding in Postoperative Lower Extremity Casting: An Inexpensive Way to Protect Patients. 61
29927792 2018
23
An investigation of intra-individual variability in children with fetal alcohol spectrum disorder (FASD). 61
28301980 2018
24
The epilepsy phenotypic spectrum associated with a recurrent CUX2 variant. 61
29630738 2018
25
Challenges of diagnosing fetal alcohol spectrum disorders in foster and adopted children. 61
29316477 2018
26
Deep brain stimulation in cerebral palsy: Time for dynamism in a static encephalopathy. 61
29447767 2018
27
Patterns of Care at the End of Life for Children and Young Adults with Life-Threatening Complex Chronic Conditions. 61
29174080 2018
28
Prevalence of Fetal Alcohol Spectrum Disorders in 4 US Communities. 61
29411031 2018
29
Neurological and neuropsychological effects of low and moderate prenatal alcohol exposure. 61
28470828 2018
30
Computer-Aided Recognition of Facial Attributes for Fetal Alcohol Spectrum Disorders. 61
29187580 2017
31
Late diagnosis and atypical brain imaging of Aicardi-Goutières syndrome: are we failing to diagnose Aicardi-Goutières syndrome-2? 61
28762473 2017
32
[Formula: see text]Social perception in children with fetal alcohol spectrum disorder. 61
27829119 2017
33
Nocturnal incontinence in children with fetal alcohol spectrum disorders (FASD) in a South African cohort. 61
28381366 2017
34
Profile of children diagnosed with a fetal alcohol spectrum disorder: A retrospective chart review. 61
28334461 2017
35
Ten-year experience of fetal alcohol spectrum disorder; diagnostic and resource challenges in Indigenous children. 61
29479201 2017
36
Validation of the Polish Version of the Washington 4-Digit Diagnostic Code for the Assessment of Fetal Alcohol Spectrum Disorders. 61
28581541 2017
37
A novel WDR45 mutation in a patient with β-propeller protein-associated neurodegeneration. 61
27957548 2017
38
Comparison of the FASD 4-Digit Code and Hoyme et al. 2016 FASD diagnostic guidelines. 61
33409370 2017
39
Comparing diagnostic classification of neurobehavioral disorder associated with prenatal alcohol exposure with the Canadian fetal alcohol spectrum disorder guidelines: a cohort study. 61
28401132 2017
40
A Case of Beta-propeller Protein-associated Neurodegeneration due to a Heterozygous Deletion of WDR45. 61
29082105 2017
41
Cortical miscommunication after prenatal exposure to alcohol. 61
27491551 2016
42
What we know of the central auditory disorders in children exposed to alcohol during pregnancy? Systematic review. 61
27849248 2016
43
Updated Clinical Guidelines for Diagnosing Fetal Alcohol Spectrum Disorders. 61
27464676 2016
44
Acute Infantile Encephalopathy as Presentation of Succinic Semialdehyde Dehydrogenase Deficiency. 61
27268762 2016
45
Case Report: The Specter of Untreated Congenital Hypothyroidism in Immigrant Families. 61
27244801 2016
46
A Comparison Among 5 Methods for the Clinical Diagnosis of Fetal Alcohol Spectrum Disorders. 61
27028727 2016
47
Elevation of neuron specific enolase and brain iron deposition on susceptibility-weighted imaging as diagnostic clues for beta-propeller protein-associated neurodegeneration in early childhood: Additional case report and review of the literature. 61
26481852 2016
48
Comparison of Efficacy and Side Effects of Oral Baclofen Versus Tizanidine Therapy with Adjuvant Botulinum Toxin Type A in Children With Cerebral Palsy and Spastic Equinus Foot Deformity. 61
25999301 2016
49
Worldwide Prevalence of Fetal Alcohol Spectrum Disorders: A Systematic Literature Review Including Meta-Analysis. 61
26727519 2016
50
The Function of Autophagy in Neurodegenerative Diseases. 61
26569220 2015

Variations for Alcohol-Related Neurodevelopmental Disorder

Expression for Alcohol-Related Neurodevelopmental Disorder

Search GEO for disease gene expression data for Alcohol-Related Neurodevelopmental Disorder.

Pathways for Alcohol-Related Neurodevelopmental Disorder

GO Terms for Alcohol-Related Neurodevelopmental Disorder

Cellular components related to Alcohol-Related Neurodevelopmental Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phagophore assembly site GO:0000407 9.26 WIPI2 WDR45
2 phagophore assembly site membrane GO:0034045 9.16 WIPI2 WDR45
3 lysosome GO:0005764 9.02 WDR81 SNX14 KPTN GRIN2B EPG5
4 preribosome, small subunit precursor GO:0030688 8.96 RIOK2 RIOK1

Biological processes related to Alcohol-Related Neurodevelopmental Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ribosomal small subunit biogenesis GO:0042274 9.43 RIOK2 RIOK1
2 maturation of SSU-rRNA GO:0030490 9.4 RIOK2 RIOK1
3 protein localization to phagophore assembly site GO:0034497 9.37 WIPI2 WDR45
4 protein lipidation GO:0006497 9.32 WIPI2 WDR45
5 positive regulation of rRNA processing GO:2000234 9.26 RIOK2 RIOK1
6 autophagy GO:0006914 9.26 WIPI2 WDR45 EPG5 C19orf12
7 autophagy of nucleus GO:0044804 9.16 WIPI2 WDR45
8 autophagosome maturation GO:0097352 8.8 WIPI2 SNX14 EPG5

Molecular functions related to Alcohol-Related Neurodevelopmental Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol-3,5-bisphosphate binding GO:0080025 8.8 WIPI2 WDR45 SNX14

Sources for Alcohol-Related Neurodevelopmental Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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