MCID: ALC002
MIFTS: 24

Alcohol-Related Neurodevelopmental Disorder

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Alcohol-Related Neurodevelopmental Disorder

MalaCards integrated aliases for Alcohol-Related Neurodevelopmental Disorder:

Name: Alcohol-Related Neurodevelopmental Disorder 12 15
Static Encephalopathy 12 74
Alcohol Related Neurodevelopmental Disorder 74
Arnd 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050667

Summaries for Alcohol-Related Neurodevelopmental Disorder

Disease Ontology : 12 A fetal alcohol spectrum disorder that results in central nervous system dysfunction and behavioral and/or cognitive deficits due to prenatal alcohol exposure.

MalaCards based summary : Alcohol-Related Neurodevelopmental Disorder, also known as static encephalopathy, is related to fetal alcohol spectrum disorder and neurodegeneration with brain iron accumulation 5. An important gene associated with Alcohol-Related Neurodevelopmental Disorder is PFAS (Phosphoribosylformylglycinamidine Synthase). The drugs Ethanol and Choline have been mentioned in the context of this disorder. Affiliated tissues include brain.

Related Diseases for Alcohol-Related Neurodevelopmental Disorder

Diseases related to Alcohol-Related Neurodevelopmental Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 18)
# Related Disease Score Top Affiliating Genes
1 fetal alcohol spectrum disorder 32.7 CUX2 PFAS
2 neurodegeneration with brain iron accumulation 5 12.4
3 fetal alcohol syndrome 12.3
4 encephalopathy 10.5
5 baker-gordon syndrome 10.3
6 alcohol-related birth defect 10.3
7 partial fetal alcohol syndrome 10.0
8 substance abuse 10.0
9 cerebral palsy 10.0
10 developmental dysplasia of the hip 1 9.8
11 schizophrenia 9.8
12 scoliosis 9.8
13 dystonia 9.8
14 axonal neuropathy 9.8
15 neuropathy 9.8
16 toxocariasis 9.8
17 seizure disorder 9.8
18 glycine encephalopathy 9.7 BOLA3 GCSH

Graphical network of the top 20 diseases related to Alcohol-Related Neurodevelopmental Disorder:



Diseases related to Alcohol-Related Neurodevelopmental Disorder

Symptoms & Phenotypes for Alcohol-Related Neurodevelopmental Disorder

Drugs & Therapeutics for Alcohol-Related Neurodevelopmental Disorder

Drugs for Alcohol-Related Neurodevelopmental Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 1, Phase 2,Phase 2,Not Applicable 64-17-5 702
2
Choline Approved, Nutraceutical Phase 2,Phase 1 62-49-7 305
3 Anti-Infective Agents, Local Phase 1, Phase 2,Phase 2,Not Applicable
4 Central Nervous System Depressants Phase 1, Phase 2,Phase 2,Not Applicable
5 Anti-Infective Agents Phase 1, Phase 2,Phase 2,Not Applicable
6 Lipid Regulating Agents Phase 2,Phase 1
7 Hypolipidemic Agents Phase 2,Phase 1
8 Gastrointestinal Agents Phase 2,Phase 1
9 Antimetabolites Phase 2,Phase 1
10 Nootropic Agents Phase 2,Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Neurocognitive Habilitation for Children With Fetal Alcohol Syndrome (FAS)/Alcohol-Related Neurodevelopmental Disorder (ARND) Completed NCT00164346 Phase 1, Phase 2
2 Choline Supplementation in Children With Fetal Alcohol Spectrum Disorders Completed NCT01911299 Phase 2
3 Postnatal Choline Supplementation in Children With Prenatal Alcohol Exposure Completed NCT01149538 Phase 1, Phase 2 Choline bitartrate
4 Development of Education Materials for Prevention of FAS in Russia Completed NCT01971398 Not Applicable
5 Expansion to Interdisciplinary HIV Prevention in Women Completed NCT01994603 Not Applicable
6 Preventing FAS/ARND in Russian Children Completed NCT01961050 Not Applicable
7 Parenting Training for Children With FASD Completed NCT02210455 Not Applicable
8 Optic Discs in Children With Cerebral Palsy Completed NCT00769197

Search NIH Clinical Center for Alcohol-Related Neurodevelopmental Disorder

Genetic Tests for Alcohol-Related Neurodevelopmental Disorder

Anatomical Context for Alcohol-Related Neurodevelopmental Disorder

MalaCards organs/tissues related to Alcohol-Related Neurodevelopmental Disorder:

42
Brain

Publications for Alcohol-Related Neurodevelopmental Disorder

Articles related to Alcohol-Related Neurodevelopmental Disorder:

(show all 24)
# Title Authors Year
1
Observation of novel COX20 mutations related to autosomal recessive axonal neuropathy and static encephalopathy. ( 31079202 )
2019
2
De novo missense variant in the GTPase effector domain (GED) of DNM1L leads to static encephalopathy and seizures. ( 30850373 )
2019
3
Deep brain stimulation in cerebral palsy: Time for dynamism in a static encephalopathy. ( 29447767 )
2018
4
Visual search for feature conjunctions: an fMRI study comparing alcohol-related neurodevelopmental disorder (ARND) to ADHD. ( 25750685 )
2015
5
Hippocampal abnormalities in youth with alcohol-related neurodevelopmental disorder. ( 24512673 )
2014
6
Cortical morphology in children with alcohol-related neurodevelopmental disorder. ( 24653953 )
2014
7
A novel WDR45 mutation in a patient with static encephalopathy of childhood with neurodegeneration in adulthood (SENDA). ( 25044655 )
2014
8
MRI, MR spectroscopy, and diffusion tensor imaging findings in patient with static encephalopathy of childhood with neurodegeneration in adulthood (SENDA). ( 22892189 )
2013
9
First video report of static encephalopathy of childhood with neurodegeneration in adulthood. ( 23390121 )
2013
10
De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood. ( 23435086 )
2013
11
WDR45 mutations define a novel disease entity--static encephalopathy of childhood with neurodegeneration in adulthood. ( 23647500 )
2013
12
Results and complications after spinal fusion for neuromuscular scoliosis in cerebral palsy and static encephalopathy using luque galveston instrumentation: experience in 93 patients. ( 21673625 )
2012
13
Excessive hip flexion during gait in patients with static encephalopathy: an examination of contributing factors. ( 20733421 )
2010
14
Creatine transporter deficiency in two adult patients with static encephalopathy. ( 19319661 )
2009
15
The Toronto experience in diagnosing alcohol-related neurodevelopmental disorder: a unique profile of deficits and assets. ( 12584580 )
2002
16
Violent recurrent ballism associated with infections in two children with static encephalopathy. ( 10830425 )
2000
17
The effect of unilateral varus rotational osteotomy with or without pelvic osteotomy on the contralateral hip in patients with perinatal static encephalopathy. ( 9821127 )
1998
18
Incidence of fetal alcohol syndrome and prevalence of alcohol-related neurodevelopmental disorder. ( 9451756 )
1997
19
What research with animals is telling us about alcohol-related neurodevelopmental disorder. ( 8981579 )
1996
20
Pemberton pelvic osteotomy and varus rotational osteotomy in the treatment of acetabular dysplasia in patients who have static encephalopathy. ( 8986664 )
1996
21
Course of schizophrenia: neuropsychological evidence for a static encephalopathy. ( 8303228 )
1993
22
Visceral larva migrans producing static encephalopathy in an infant. ( 2067891 )
1991
23
Parents' grief reaction to the diagnosis of their infant's severe neurologic impairment and static encephalopathy. ( 3047361 )
1988
24
Delayed-onset dystonia in patients with "static" encephalopathy. ( 7191439 )
1980

Variations for Alcohol-Related Neurodevelopmental Disorder

Expression for Alcohol-Related Neurodevelopmental Disorder

Search GEO for disease gene expression data for Alcohol-Related Neurodevelopmental Disorder.

Pathways for Alcohol-Related Neurodevelopmental Disorder

GO Terms for Alcohol-Related Neurodevelopmental Disorder

Sources for Alcohol-Related Neurodevelopmental Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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