ARND
MCID: ALC002
MIFTS: 30

Alcohol-Related Neurodevelopmental Disorder (ARND)

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Alcohol-Related Neurodevelopmental Disorder

MalaCards integrated aliases for Alcohol-Related Neurodevelopmental Disorder:

Name: Alcohol-Related Neurodevelopmental Disorder 12 15
Static Encephalopathy 12 71
Alcohol Related Neurodevelopmental Disorder 71
Arnd 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050667
UMLS 71 C0814154 C3662068

Summaries for Alcohol-Related Neurodevelopmental Disorder

Disease Ontology : 12 A fetal alcohol spectrum disorder that results in central nervous system dysfunction and behavioral and/or cognitive deficits due to prenatal alcohol exposure.

MalaCards based summary : Alcohol-Related Neurodevelopmental Disorder, also known as static encephalopathy, is related to fetal alcohol syndrome and neurodegeneration with brain iron accumulation 5. An important gene associated with Alcohol-Related Neurodevelopmental Disorder is PFAS (Phosphoribosylformylglycinamidine Synthase). The drugs Ethanol and Choline have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and testes.

Related Diseases for Alcohol-Related Neurodevelopmental Disorder

Diseases related to Alcohol-Related Neurodevelopmental Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Related Disease Score Top Affiliating Genes
1 fetal alcohol syndrome 33.5 PFAS PAF1 GRIN2B
2 neurodegeneration with brain iron accumulation 5 33.1 WDR45 SNX14 EPG5 C19orf12
3 fetal alcohol spectrum disorder 32.1 WDR45 PFAS PAF1 MECP2 GRIN2B FASTK
4 alcohol-related birth defect 31.2 SIMC1 PFAS
5 neurodegeneration with brain iron accumulation 30.4 WDR45 SNX14 C19orf12
6 neurodegeneration with brain iron accumulation 1 30.0 WDR45 C19orf12
7 leukoencephalopathy, cystic, without megalencephaly 11.2
8 mecp2-related severe neonatal encephalopathy 11.2
9 encephalopathy 10.5
10 neurodegeneration with brain iron accumulation 4 10.3 WDR45 C19orf12
11 juvenile-onset parkinson's disease 10.3 WDR45 C19orf12
12 spastic paraplegia 35, autosomal recessive 10.3 WDR45 C19orf12
13 neurodegeneration with brain iron accumulation 3 10.3 WDR45 C19orf12
14 neurodegeneration with brain iron accumulation 6 10.3 WDR45 C19orf12
15 cecum adenocarcinoma 10.2 RIOK2 RIOK1
16 neurodegeneration with brain iron accumulation 2a 10.2 WDR45 C19orf12
17 pitt-hopkins-like syndrome 1 10.1 SNX14 MECP2
18 kufor-rakeb syndrome 10.1 WDR45 C19orf12
19 cerebral palsy 10.1
20 atypical autism 10.0 PAF1 MECP2
21 hand skill, relative 10.0
22 attention deficit-hyperactivity disorder 10.0
23 partial fetal alcohol syndrome 10.0
24 substance abuse 10.0
25 ataxia and polyneuropathy, adult-onset 10.0
26 locked-in syndrome 10.0
27 quadriplegia 10.0
28 dystonia 10.0
29 hypotonia 10.0
30 schizophrenia 9.8
31 3-methylglutaconic aciduria, type iii 9.8
32 encephalopathy due to defective mitochondrial and peroxisomal fission 1 9.8
33 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 9.8
34 scoliosis 9.8
35 myoglobinuria 9.8
36 hemiplegia 9.8
37 visual epilepsy 9.8
38 movement disease 9.8
39 axonal neuropathy 9.8
40 neuropathy 9.8
41 pathologic nystagmus 9.8
42 toxocariasis 9.8
43 creatine deficiency syndromes 9.8
44 hip subluxation 9.8
45 anoxia 9.8
46 seizure disorder 9.8
47 spasticity 9.8
48 early-onset generalized limb-onset dystonia 9.8
49 cecum carcinoma 9.8 RIOK2 RIOK1
50 spinocerebellar ataxia, autosomal recessive 20 9.8 WDR45 SNX14 EPG5

Graphical network of the top 20 diseases related to Alcohol-Related Neurodevelopmental Disorder:



Diseases related to Alcohol-Related Neurodevelopmental Disorder

Symptoms & Phenotypes for Alcohol-Related Neurodevelopmental Disorder

Drugs & Therapeutics for Alcohol-Related Neurodevelopmental Disorder

Drugs for Alcohol-Related Neurodevelopmental Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 1, Phase 2 64-17-5 702
2
Choline Approved, Nutraceutical Phase 2 62-49-7 305
3 Gastrointestinal Agents Phase 2
4 Hypolipidemic Agents Phase 2
5 Nootropic Agents Phase 2
6 Lipid Regulating Agents Phase 2
7 Antimetabolites Phase 2
8 Central Nervous System Depressants
9 Anti-Infective Agents, Local
10 Anti-Infective Agents

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Neurocognitive Habilitation for Children With FAS/ARND Completed NCT00164346 Phase 1, Phase 2
2 Choline Supplementation in Children With Fetal Alcohol Spectrum Disorders Completed NCT01911299 Phase 2
3 Fetal Alcohol Syndrome/ARND Research Consortion-Oklahoma Completed NCT00164554 Phase 1, Phase 2
4 Intervening With Children/Adolescents With FAS/ARND Completed NCT00164528 Phase 1, Phase 2
5 Study to Investigate the Effectiveness of a Math Intervention for Children With Fetal Alcohol Syndrome or Related Condition Completed NCT00164229 Phase 1, Phase 2
6 Assisting Children With Prenatal Alcohol Exposure in Developing Peer Friendships Completed NCT00164307 Phase 1, Phase 2
7 Strongest Families FASD: Parent Training for Challenging Behaviour in Children With Fetal Alcohol Spectrum Disorder (FASD) Completed NCT02210455
8 Preventing FAS/ARND in Russian Children Completed NCT01961050
9 Preventing FAS/ARND in Russian Children/Expansion to Interdisciplinary HIV Prevention in Women Completed NCT01994603
10 Optic Nerve Head Morphology in Children With Perinatal Onset Static Encephalopathy Completed NCT00769197
11 Development of Education Materials for Prevention of Fetal Alcohol Syndrome (FAS) in Russia Completed NCT01971398
12 Reducing Alcohol Exposed Pregnancy Risk Completed NCT01446653
13 Augmented Biofeedback Training Combined With Physical Therapy Program Improves Visual-motor Integration, Visual Perception and Motor Coordination in Children With Spastic Hemiplegic Cerebral Palsy: a Randomized Control Trial Completed NCT03626077
14 Dissecting the Genetics of Fetal Alcohol Spectrum Disorders Recruiting NCT04072809
15 Effectiveness of Visual and Auditory Feedback on Eye-hand Coordination in Children With Hemiplegic Cerebral Palsy Recruiting NCT03742999

Search NIH Clinical Center for Alcohol-Related Neurodevelopmental Disorder

Genetic Tests for Alcohol-Related Neurodevelopmental Disorder

Anatomical Context for Alcohol-Related Neurodevelopmental Disorder

MalaCards organs/tissues related to Alcohol-Related Neurodevelopmental Disorder:

40
Brain, Eye, Testes

Publications for Alcohol-Related Neurodevelopmental Disorder

Articles related to Alcohol-Related Neurodevelopmental Disorder:

(show top 50) (show all 214)
# Title Authors PMID Year
1
Fetal Alcohol Spectrum Disorders in a Pacific Southwest City: Maternal and Child Characteristics. 61
31688971 2019
2
Is WDR45 the missing link for ER stress-induced autophagy in beta-propeller associated neurodegeneration? 61
31525124 2019
3
New-onset lesional and nonlesional epilepsy in the US population: Patient characteristics and patterns of antiepileptic drug use. 61
31605878 2019
4
Observation of novel COX20 mutations related to autosomal recessive axonal neuropathy and static encephalopathy. 61
31079202 2019
5
De novo missense variant in the GTPase effector domain (GED) of DNM1L leads to static encephalopathy and seizures. 61
30850373 2019
6
Relationship of muscle morphology to hip displacement in cerebral palsy: a pilot study investigating changes intrinsic to the sarcomere. 61
31227002 2019
7
Foam Padding in Postoperative Lower Extremity Casting: An Inexpensive Way to Protect Patients. 61
29927792 2018
8
An investigation of intra-individual variability in children with fetal alcohol spectrum disorder (FASD). 61
28301980 2018
9
The epilepsy phenotypic spectrum associated with a recurrent CUX2 variant. 61
29630738 2018
10
Challenges of diagnosing fetal alcohol spectrum disorders in foster and adopted children. 61
29316477 2018
11
Deep brain stimulation in cerebral palsy: Time for dynamism in a static encephalopathy. 61
29447767 2018
12
Prevalence of Fetal Alcohol Spectrum Disorders in 4 US Communities. 61
29411031 2018
13
Patterns of Care at the End of Life for Children and Young Adults with Life-Threatening Complex Chronic Conditions. 61
29174080 2018
14
Neurological and neuropsychological effects of low and moderate prenatal alcohol exposure. 61
28470828 2018
15
Computer-Aided Recognition of Facial Attributes for Fetal Alcohol Spectrum Disorders. 61
29187580 2017
16
Late diagnosis and atypical brain imaging of Aicardi-Goutières syndrome: are we failing to diagnose Aicardi-Goutières syndrome-2? 61
28762473 2017
17
[Formula: see text]Social perception in children with fetal alcohol spectrum disorder. 61
27829119 2017
18
Nocturnal incontinence in children with fetal alcohol spectrum disorders (FASD) in a South African cohort. 61
28381366 2017
19
Profile of children diagnosed with a fetal alcohol spectrum disorder: A retrospective chart review. 61
28334461 2017
20
Ten-year experience of fetal alcohol spectrum disorder; diagnostic and resource challenges in Indigenous children. 61
29479201 2017
21
Validation of the Polish Version of the Washington 4-Digit Diagnostic Code for the Assessment of Fetal Alcohol Spectrum Disorders. 61
28581541 2017
22
A novel WDR45 mutation in a patient with β-propeller protein-associated neurodegeneration. 61
27957548 2017
23
A Case of Beta-propeller Protein-associated Neurodegeneration due to a Heterozygous Deletion of WDR45. 61
29082105 2017
24
Comparing diagnostic classification of neurobehavioral disorder associated with prenatal alcohol exposure with the Canadian fetal alcohol spectrum disorder guidelines: a cohort study. 61
28401132 2017
25
Cortical miscommunication after prenatal exposure to alcohol. 61
27491551 2016
26
What we know of the central auditory disorders in children exposed to alcohol during pregnancy? Systematic review. 61
27849248 2016
27
Updated Clinical Guidelines for Diagnosing Fetal Alcohol Spectrum Disorders. 61
27464676 2016
28
Acute Infantile Encephalopathy as Presentation of Succinic Semialdehyde Dehydrogenase Deficiency. 61
27268762 2016
29
Case Report: The Specter of Untreated Congenital Hypothyroidism in Immigrant Families. 61
27244801 2016
30
A Comparison Among 5 Methods for the Clinical Diagnosis of Fetal Alcohol Spectrum Disorders. 61
27028727 2016
31
Elevation of neuron specific enolase and brain iron deposition on susceptibility-weighted imaging as diagnostic clues for beta-propeller protein-associated neurodegeneration in early childhood: Additional case report and review of the literature. 61
26481852 2016
32
Comparison of Efficacy and Side Effects of Oral Baclofen Versus Tizanidine Therapy with Adjuvant Botulinum Toxin Type A in Children With Cerebral Palsy and Spastic Equinus Foot Deformity. 61
25999301 2016
33
Worldwide Prevalence of Fetal Alcohol Spectrum Disorders: A Systematic Literature Review Including Meta-Analysis. 61
26727519 2016
34
The Function of Autophagy in Neurodegenerative Diseases. 61
26569220 2015
35
Fetal alcohol spectrum disorders among children in a Brazilian orphanage. 61
25371388 2015
36
Misdiagnosis and missed diagnoses in foster and adopted children with prenatal alcohol exposure. 61
25583914 2015
37
Analysis of the C19orf12 and WDR45 genes in patients with neurodegeneration with brain iron accumulation. 61
25592411 2015
38
Prolonged ileus in an infant presenting with primary congenital hypothyroidism. 61
25866693 2015
39
Visual search for feature conjunctions: an fMRI study comparing alcohol-related neurodevelopmental disorder (ARND) to ADHD. 61
25750685 2015
40
Mental Health Disorders among Children within Child Welfare who have Prenatal Substance Exposure: Rural vs. Urban Populations. 61
26827476 2015
41
Prevalence and characteristics of fetal alcohol spectrum disorders. 61
25349310 2014
42
A novel WDR45 mutation in a patient with static encephalopathy of childhood with neurodegeneration in adulthood (SENDA). 61
25044655 2014
43
Clinical study on the efficacy of Rajayapana Basti and Baladi Yoga in motor disabilities of cerebral palsy in children. 61
26664239 2014
44
Invited commentary on Australian fetal alcohol spectrum disorder diagnostic guidelines. 61
24685275 2014
45
Beta-propeller protein-associated neurodegeneration (BPAN), a rare form of NBIA: novel mutations and neuropsychiatric phenotype in three adult patients. 61
24368176 2014
46
Variant non ketotic hyperglycinemia is caused by mutations in LIAS, BOLA3 and the novel gene GLRX5. 61
24334290 2014
47
Hippocampal abnormalities in youth with alcohol-related neurodevelopmental disorder. 61
24512673 2014
48
Hip problems in cerebral palsy: screening, diagnosis and treatment. 61
24299910 2014
49
Fetal alcohol spectrum disorder and the neurobehavioural screening tool: evaluating the effect of maternal depression. 61
25353623 2014
50
Screening for fetal alcohol spectrum disorders by nonmedical community workers. 61
25658901 2014

Variations for Alcohol-Related Neurodevelopmental Disorder

Expression for Alcohol-Related Neurodevelopmental Disorder

Search GEO for disease gene expression data for Alcohol-Related Neurodevelopmental Disorder.

Pathways for Alcohol-Related Neurodevelopmental Disorder

GO Terms for Alcohol-Related Neurodevelopmental Disorder

Cellular components related to Alcohol-Related Neurodevelopmental Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 preribosome, small subunit precursor GO:0030688 8.62 RIOK2 RIOK1

Biological processes related to Alcohol-Related Neurodevelopmental Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 autophagy GO:0006914 9.54 WDR45 EPG5 C19orf12
2 autophagosome maturation GO:0097352 9.4 SNX14 EPG5
3 ribosomal small subunit biogenesis GO:0042274 9.32 RIOK2 RIOK1
4 purine ribonucleoside monophosphate biosynthetic process GO:0009168 9.26 PFAS AMPD2
5 maturation of SSU-rRNA GO:0030490 9.16 RIOK2 RIOK1
6 positive regulation of rRNA processing GO:2000234 8.96 RIOK2 RIOK1
7 glutamine metabolic process GO:0006541 8.8 PFAS MECP2 ALDH5A1

Molecular functions related to Alcohol-Related Neurodevelopmental Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol-3,5-bisphosphate binding GO:0080025 8.62 WDR45 SNX14

Sources for Alcohol-Related Neurodevelopmental Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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