MCID: ALC016
MIFTS: 30

Alcohol Sensitivity, Acute

Categories: Genetic diseases, Mental diseases, Rare diseases

Aliases & Classifications for Alcohol Sensitivity, Acute

MalaCards integrated aliases for Alcohol Sensitivity, Acute:

Name: Alcohol Sensitivity, Acute 57 13
Acute Alcohol Sensitivity 53 37 29 6 40
Hangover, Susceptibility to 57 53
Susceptibility to Hangover 6
Alcohol Intolerance 53
Hangover 57

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant

Miscellaneous:
aldh2*1 and aldh2*2 are inactive alleles found more commonly in asians


HPO:

32
alcohol sensitivity, acute:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 610251
KEGG 37 H01071
MedGen 42 C2674838

Summaries for Alcohol Sensitivity, Acute

NIH Rare Diseases : 53 Alcohol intolerance is characterized by immediate unpleasant reactions after drinking alcohol. The most common signs and symptoms of alcohol intolerance are stuffy nose and skin flushing. Alcohol intolerance is caused by a genetic condition in which the body is unable to break down alcohol efficiently. It is most common in Asians. These individuals accumulate acetaldehyde, the primary metabolite of ethanol, because of a genetic polymorphism that doesn't allow aldehyde dehydrogenase (ALDH) to metabolize acetaldehyde to nontoxic acetate. The only way to prevent alcohol intolerance reactions is to avoid alcohol. Alcohol intolerance isn't an allergy. However, in some cases, what seems to be alcohol intolerance may be a reaction to something in an alcoholic beverage, such as chemicals, grains, or preservatives. Combining alcohol with certain medications also can cause reactions. In rare instances, an unpleasant reaction to alcohol can be a sign of a serious underlying health problem that requires diagnosis and treatment.

MalaCards based summary : Alcohol Sensitivity, Acute, also known as acute alcohol sensitivity, is related to migraine with or without aura 1 and lymphoma, hodgkin, classic. An important gene associated with Alcohol Sensitivity, Acute is ALDH2 (Aldehyde Dehydrogenase 2 Family Member), and among its related pathways/superpathways is Glycolysis / Gluconeogenesis. The drugs Acetaminophen and Ibuprofen have been mentioned in the context of this disorder. Affiliated tissues include skin and liver, and related phenotypes are facial flushing after alcohol intake and reduced acetaldehyde dehydrogenase activity

KEGG : 37
Aldehyde dehydrogenases (ALDHs) are important enzymes that eliminate toxic aldehydes by catalysing their oxidation to non-reactive acids. It is reported that a deficiency in the ALDH2 is associated with the alcohol flush reaction. More than 40% of the East Asians population carries a common ALDH2 mutant allele, which results in a dramatic reduction in the enzymatic activity when compared with the wild-type allele.

More information from OMIM: 610251

Related Diseases for Alcohol Sensitivity, Acute

Diseases in the Alcohol Use Disorder family:

Alcohol Sensitivity, Acute

Diseases related to Alcohol Sensitivity, Acute via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 migraine with or without aura 1 9.8
2 lymphoma, hodgkin, classic 9.8
3 sleep apnea 9.8
4 lymphoma 9.8
5 hypereosinophilic syndrome 9.8
6 alcohol dependence 9.8
7 alcohol use disorder 9.8

Graphical network of the top 20 diseases related to Alcohol Sensitivity, Acute:



Diseases related to Alcohol Sensitivity, Acute

Symptoms & Phenotypes for Alcohol Sensitivity, Acute

Human phenotypes related to Alcohol Sensitivity, Acute:

32
# Description HPO Frequency HPO Source Accession
1 facial flushing after alcohol intake 32 HP:0001033
2 reduced acetaldehyde dehydrogenase activity 32 HP:0003533

Symptoms via clinical synopsis from OMIM:

57
Head And Neck Face:
facial flushing after alcohol intake

Metabolic Features:
excessive acetaldehyde accumulation after alcohol consumption

Neurologic Behavioral Psychiatric Manifestations:
increased intoxicating symptoms after alcohol consumption
aldh2*2 carriers suffer more severe hangovers

Laboratory Abnormalities:
enzymatically inactive aldh2
delayed oxidation of acetaldehyde

Clinical features from OMIM:

610251

Drugs & Therapeutics for Alcohol Sensitivity, Acute

Drugs for Alcohol Sensitivity, Acute (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 67)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 4 103-90-2 1983
2
Ibuprofen Approved Phase 4 15687-27-1 3672
3 Cyclooxygenase Inhibitors Phase 4
4 Anti-Inflammatory Agents, Non-Steroidal Phase 4
5 Anti-Inflammatory Agents Phase 4
6 Antirheumatic Agents Phase 4
7 Antipyretics Phase 4
8
Ethanol Approved Phase 2 64-17-5 702
9
Fomepizole Approved, Vet_approved Phase 2 7554-65-6 3406
10
Sumatriptan Approved, Investigational Phase 2 103628-46-2 5358
11
Aspirin Approved, Vet_approved Phase 2 50-78-2 2244
12
Sulforaphane Investigational Phase 2 4478-93-7, 142825-10-3 5350
13 Anti-Infective Agents, Local Phase 2
14 Anti-Infective Agents Phase 2
15 Antidotes Phase 2
16 Liver Extracts Phase 2
17 Sulforafan Phase 2
18 Serotonin Receptor Agonists Phase 2
19 Fibrinolytic Agents Phase 2
20 Serotonin 5-HT1 Receptor Agonists Phase 2
21 Serotonin Agents Phase 2
22 Platelet Aggregation Inhibitors Phase 2
23 Vasoconstrictor Agents Phase 2
24
Serotonin Investigational, Nutraceutical Phase 2 50-67-9 5202
25
Fexofenadine Approved, Investigational Phase 1 83799-24-0 3348
26
Oxymetazoline Approved, Investigational Phase 1 1491-59-4 4636
27
Histamine Approved, Investigational Phase 1 51-45-6 774
28
Phenylephrine Approved Phase 1 59-42-7 6041
29
Naproxen Approved, Vet_approved Phase 1 22204-53-1 1302 156391
30
Oxazepam Approved Phase 1 604-75-1 4616
31
Valerian Approved, Experimental, Investigational Phase 1 8057-49-6
32
Zopiclone Approved Phase 1 43200-80-2 5735
33
Daidzin Experimental Phase 1 552-66-9 107971
34
Daidzein Experimental Phase 1 486-66-8 5281708
35 Anti-Allergic Agents Phase 1
36
Histamine Phosphate Phase 1 51-74-1 65513
37 Histamine Antagonists Phase 1
38 Histamine H1 Antagonists Phase 1
39 Histamine H1 Antagonists, Non-Sedating Phase 1
40 Lemon Balm Phase 1
41 Pharmaceutical Solutions Phase 1
42 Soy Bean Phase 1
43
Fentanyl Approved, Illicit, Investigational, Vet_approved 437-38-7 3345
44
Remifentanil Approved 132875-61-7 60815
45
Midazolam Approved, Illicit 59467-70-8 4192
46
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
47
Acetylcysteine Approved, Investigational 616-91-1 12035
48
Melatonin Approved, Nutraceutical, Vet_approved 73-31-4 896
49 Tranquilizing Agents
50 Anti-Anxiety Agents

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 Ibuprofen vs Acetaminophen in the Prevention of Acute Mountain Sickness: A Double Blind, Randomized Controlled Trial Completed NCT02244437 Phase 4 Ibuprofen;Acetaminophen
2 Residual Effects of Intoxication on Student Performance Unknown status NCT00183170 Phase 2 Beer (alcohol)
3 Phyllantus Amarus for the Protection of Liver Health: A Randomized, Double Blind, Placebo Controlled Crossover Study Completed NCT03349697 Phase 2
4 Prevention of Alcohol Intolerance Completed NCT01845220 Phase 2 Broccoli Sprout Extract;Placebo
5 Hangover, Congeners, Sleep and Occupational Performance Completed NCT00247585 Phase 2 Ethanol (Bourbon or Vodka)
6 A Phase IIa, Prospective, Randomized, Blinded, Intra-Subject Controlled, Single Dose, Dose Escalation Study of Antizol® for Mitigation of Acetaldehyde Related Toxicity in Human Subjects With Symptoms of Inborn Altered Ethanol Metabolism With Concomitant Ethanol Exposure Completed NCT00661141 Phase 2 Antizol;Placebo
7 Multi-Center, Double-Blind, Placebo Controlled Pilot Study of VVD-101 for the Treatment of Delayed Alcohol-Induced Headaches Completed NCT02176655 Phase 2 VVD-101;Placebo
8 Prospective, Double Blinded,Randomized Controlled Trial of Dexmedetomidine Versus Chloral Hydrate for Pediatric Sedation During EEG Withdrawn NCT00464451 Phase 2 Dexmedetomidine;Chloral hydrate
9 A Double-Blind, Placebo-Controlled, 4-Way Crossover Study to Evaluate the Pharmacokinetics and Pharmacodynamics at Two Dose Levels of JMI-001 in Comparison With Fexofenadine and Naproxen Administered in Conjunction With Alcohol. Unknown status NCT03183297 Phase 1 JMI-001;Naproxen;Fexofenadine;placebo
10 A Randomised, Double-blind, Double-dummy, Placebo-controlled Cross-over Trial to Evaluate the Presence of a Hangover Effect in Healthy Adults After Administration of Songha® Night Tablets (120 mg Valerian / 80 mg Lemon Balm) Completed NCT02273453 Phase 1 Songha® Night;Oxazepam;Placebo
11 Human Pharmacology Study to Evaluate the Interaction Between a Natural Inhibitor of Aldehyde Dehydrogenase 2 (ALDH2) and Alcohol in Healthy Volunteers. Pilot Clinical Trial Completed NCT02309801 Phase 1
12 The Effect of Alcohol Hangover and Night-time Zopiclone on Next-morning Spatial Perception in Healthy Young Volunteers Not yet recruiting NCT03632408 Phase 1 Zopiclone;Placebo oral capsule
13 Does Mixing Alcoholic Drinks Make Hangover Worse? A Randomized Controlled Trial in a Naturalistic Setting Completed NCT03506516
14 Use of NAC in Alleviation of Hangover Symptoms Completed NCT02541422
15 A Naturalistic Study Comparing the Hangover Effects of MDMA, Other Drugs, and Alcohol in a Sample of Recreational Polydrug Users Completed NCT01400204
16 Effect of Glutathione on Blood Alcohol and Hangover Symptoms Completed NCT00127309 Glutathione
17 Change in Peripheral Oxygen Saturation by Using Different Breathing Procedures in High Altitude Completed NCT01468194
18 The Effect of Acupuncture on Pre-operative Anxiety Levels in Neurosurgical Patients: a Randomised, Controlled Trail Completed NCT02561572
19 The Relative Bio-availability of Oral and Oromucosal Melatonin in Different Formulations in Healthy Human Volunteers. A Three-phased Cross-over Study. Completed NCT02107079 Melatonin
20 FREquent DIalysis and Markers of Cardiac Strain and Injury, Physical Fitness, Habitual Physical Activity and Quality of Life: an Observational Pilot Study Recruiting NCT03925454
21 A Prospective Randomized Comparative Study to Evaluate the Use of Remifentanil as a Sole Agent or in Combination With Midazolam Versus Fentanyl/Midazolam During Sedation for Colonoscopy Recruiting NCT03037892 Midazolam, Fentanyl;Midazolam, Remifentanil;Remifentanil
22 The Effects of Binge Drinking on Innate Host Defence Mechanisms Enrolling by invitation NCT02568904
23 Melatonin for Preventing Postoperative Delirium in Elderly Patients; a Multi-centre Randomized Placebo Controlled Pilot Study Not yet recruiting NCT03785158
24 Use of N-acetyl Cysteine (NAC) in Alleviation or Prevention of Hangover Symptoms; Independent Alcohol Consumption Protocol Terminated NCT03104959

Search NIH Clinical Center for Alcohol Sensitivity, Acute

Genetic Tests for Alcohol Sensitivity, Acute

Genetic tests related to Alcohol Sensitivity, Acute:

# Genetic test Affiliating Genes
1 Acute Alcohol Sensitivity 29 ALDH2

Anatomical Context for Alcohol Sensitivity, Acute

MalaCards organs/tissues related to Alcohol Sensitivity, Acute:

41
Skin, Liver

Publications for Alcohol Sensitivity, Acute

Articles related to Alcohol Sensitivity, Acute:

(show all 32)
# Title Authors PMID Year
1
Hangover susceptibility in relation to aldehyde dehydrogenase-2 genotype, alcohol flushing, and mean corpuscular volume in Japanese workers. 8 71
16046871 2005
2
Association of habitual smoking and drinking with single nucleotide polymorphism (SNP) in 40 candidate genes: data from random population-based Japanese samples. 8 71
15654505 2005
3
Hangover symptoms in Asian Americans with variations in the aldehyde dehydrogenase (ALDH2) gene. 8 71
10627091 2000
4
Involvement of acetaldehyde for full protection against alcoholism by homozygosity of the variant allele of mitochondrial aldehyde dehydrogenase gene in Asians. 8 71
10780266 1999
5
The mutation in the mitochondrial aldehyde dehydrogenase (ALDH2) gene responsible for alcohol-induced flushing increases turnover of the enzyme tetramers in a dominant fashion. 8 71
8903321 1996
6
The aldehyde dehydrogenase ALDH2*2 allele exhibits dominance over ALDH2*1 in transduced HeLa cells. 8 71
7593603 1995
7
Structural mutation in a major human aldehyde dehydrogenase gene results in loss of enzyme activity. 8 71
7180842 1982
8
Alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 genotypes, alcohol drinking and the risk for esophageal cancer in a Chinese population. 71
20010786 2010
9
Major genetic components underlying alcoholism in Korean population. 71
18056758 2008
10
Pharmacokinetic and pharmacodynamic basis for partial protection against alcoholism in Asians, heterozygous for the variant ALDH2*2 gene allele. 71
17885622 2007
11
Mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys polymorphism contributes to the variation in efficacy of sublingual nitroglycerin. 71
16440063 2006
12
Cytosolic aldehyde dehydrogenase (ALDH1) variants found in alcohol flushers. 8
2729894 1989
13
Mitochondrial aldehyde dehydrogenase from human liver. Primary structure, differences in relation to the cytosolic enzyme, and functional correlations. 71
4065146 1985
14
Cloning of cDNAs for human aldehyde dehydrogenases 1 and 2. 71
2987944 1985
15
Molecular abnormality of an inactive aldehyde dehydrogenase variant commonly found in Orientals. 71
6582480 1984
16
Population genetic studies on aldehyde dehydrogenase isozyme deficiency and alcohol sensitivity. 8
6881146 1983
17
Familial resemblances in flushing following alcohol use. 8
7126112 1982
18
Aldehyde dehydrogenase deficiency as cause of facial flushing reaction to alcohol in Japanese. 8
6117742 1981
19
Liver alcohol dehydrogenase and aldehyde dehydrogenase in the Japanese: isozyme variation and its possible role in alcohol intoxication. 8
6987864 1980
20
Racial differences in alcohol sensitivity: a new hypothesis. 8
511165 1979
21
Alcohol metabolism in American Indians and whites. Lack of racial differences in metabolic rate and liver alcohol dehydrogenase. 8
1244489 1976
22
Liver alcohol dehydrogenase in Japanese: high population frequency of atypical form and its possible role in alcohol sensitivity. 8
1200030 1975
23
Ethnic differences in alcohol sensitivity. 8
5007912 1972
24
Ethanol metabolism in various racial groups. 8
5112118 1971
25
Atp1a2 contributes modestly to alcohol-related behaviors. 38
27814792 2016
26
Circadian modulation of acute alcohol sensitivity but not acute tolerance in Drosophila. 38
21721855 2011
27
Etomidate and propofol-hyposensitive GABAA receptor beta3(N265M) mice show little changes in acute alcohol sensitivity but enhanced tolerance and withdrawal. 38
17350761 2007
28
Plus-maze behavior and susceptibility to 3-mercaptopropionate-induced seizures in rat lines selected for high and low alcohol sensitivity. 38
2339161 1990
29
Genotyping of mitochondrial aldehyde dehydrogenase in blood samples using allele-specific oligonucleotides: comparison with phenotyping in hair roots. 38
2703232 1989
30
Ethanol-induced modulation of hippocampal EEG and cerebral 2-deoxyglucose accumulation in rat lines with differing alcohol sensitivities. 38
2827701 1987
31
Human aldehyde dehydrogenase isozymes and alcohol sensitivity. 38
3610592 1987
32
Polymorphism of aldehyde dehydrogenase and alcohol sensitivity. 38
3106030 1987

Variations for Alcohol Sensitivity, Acute

ClinVar genetic disease variations for Alcohol Sensitivity, Acute:

6
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 ALDH2 NM_000690.4(ALDH2): c.1510G> A (p.Glu504Lys) single nucleotide variant drug response,protective,risk factor rs671 12:112241766-112241766 12:111803962-111803962
2 ALDH2 NM_000690.4(ALDH2): c.802C> T (p.Arg268Cys) single nucleotide variant Uncertain significance 12:112229871-112229871 12:111792067-111792067

Expression for Alcohol Sensitivity, Acute

Search GEO for disease gene expression data for Alcohol Sensitivity, Acute.

Pathways for Alcohol Sensitivity, Acute

Pathways related to Alcohol Sensitivity, Acute according to KEGG:

37
# Name Kegg Source Accession
1 Glycolysis / Gluconeogenesis hsa00010

GO Terms for Alcohol Sensitivity, Acute

Sources for Alcohol Sensitivity, Acute

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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