MCID: ALC010
MIFTS: 41

Alcoholic Cardiomyopathy

Categories: Cardiovascular diseases

Aliases & Classifications for Alcoholic Cardiomyopathy

MalaCards integrated aliases for Alcoholic Cardiomyopathy:

Name: Alcoholic Cardiomyopathy 12 15
Cardiomyopathy, Alcoholic 44 73
Dilated Cardiomyopathy Secondary to Alcohol 12
Alcohol-Induced Heart Muscle Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12935
ICD10 33 I42.6
ICD9CM 35 425.5
MeSH 44 D002310
NCIt 50 C53653
SNOMED-CT 68 155352001 83521008
UMLS 73 C0007192

Summaries for Alcoholic Cardiomyopathy

MalaCards based summary : Alcoholic Cardiomyopathy, also known as cardiomyopathy, alcoholic, is related to idiopathic edema and lipid metabolism disorder. An important gene associated with Alcoholic Cardiomyopathy is PPARA (Peroxisome Proliferator Activated Receptor Alpha), and among its related pathways/superpathways are Nuclear Receptors in Lipid Metabolism and Toxicity and beta-Alanine metabolism (KEGG). The drugs Spironolactone and diuretics have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and skeletal muscle, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 76 Alcoholic cardiomyopathy is a disease in which the chronic long-term abuse of alcohol (i.e., ethanol)... more...

Related Diseases for Alcoholic Cardiomyopathy

Graphical network of the top 20 diseases related to Alcoholic Cardiomyopathy:



Diseases related to Alcoholic Cardiomyopathy

Symptoms & Phenotypes for Alcoholic Cardiomyopathy

MGI Mouse Phenotypes related to Alcoholic Cardiomyopathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.86 ACADM ACE CDK9 MSTN PPARA PPARG
2 homeostasis/metabolism MP:0005376 9.7 ACADM ACE ALDH2 MSTN PPARA PPARG
3 adipose tissue MP:0005375 9.62 ACE MSTN PPARA PPARG
4 liver/biliary system MP:0005370 9.5 PPARG SOAT2 ACADM ACE ALDH2 MSTN
5 mortality/aging MP:0010768 9.17 ACADM ACE ALDH2 CDK9 MSTN PPARA

Drugs & Therapeutics for Alcoholic Cardiomyopathy

Drugs for Alcoholic Cardiomyopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
2 diuretics Phase 4
3 Diuretics, Potassium Sparing Phase 4
4 Hormone Antagonists Phase 4
5 Hormones Phase 4
6 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
7 Mineralocorticoid Receptor Antagonists Phase 4
8 Mineralocorticoids Phase 4
9 Natriuretic Agents Phase 4
10 Liver Extracts Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Trial Studying the Effects of Spironolactone on Heart and Skeletal Muscle Function in Chronic Alcoholics Suspended NCT00226109 Phase 4 spironolactone
2 Adapted Physical Activity Effect on Aerobic Function and in Patients in Pre Liver Transplantation Recruiting NCT02567591 Not Applicable

Search NIH Clinical Center for Alcoholic Cardiomyopathy

Cochrane evidence based reviews: cardiomyopathy, alcoholic

Genetic Tests for Alcoholic Cardiomyopathy

Anatomical Context for Alcoholic Cardiomyopathy

MalaCards organs/tissues related to Alcoholic Cardiomyopathy:

41
Heart, Liver, Skeletal Muscle, Testes

Publications for Alcoholic Cardiomyopathy

Articles related to Alcoholic Cardiomyopathy:

(show top 50) (show all 163)
# Title Authors Year
1
Alcoholic Cardiomyopathy: Is it Time for Genetic Testing? ( 29773158 )
2018
2
Prognostic Impact and Predictors of Ejection Fraction Recovery in Patients With Alcoholic Cardiomyopathy. ( 29650446 )
2018
3
Alcohol puts the heart under pressure: Acetaldehyde activates a localized renin angiotensin aldosterone system within the myocardium in alcoholic cardiomyopathy. ( 29506696 )
2018
4
National, regional and global mortality due to alcoholic cardiomyopathy in 2015. ( 29535230 )
2018
5
Atria Depolarization in Rats with Alcoholic Cardiomyopathy. ( 29790023 )
2018
6
Re: Left Ventricular Strain and Rotation by 2-D Speckle Tracking Echocardiography Identify Early Alcoholic Cardiomyopathy. ( 29033096 )
2018
7
ALDH2 protects against alcoholic cardiomyopathy through a mechanism involving the p38 MAPK/CREB pathway and local renin-angiotensin system inhibition in cardiomyocytes. ( 29506687 )
2018
8
Role of autophagy and regulatory mechanisms in alcoholic cardiomyopathy. ( 29555210 )
2018
9
Expression Profiling of Circular RNAs and Micrornas in Heart Tissue of Mice with Alcoholic Cardiomyopathy. ( 29734191 )
2018
10
Incidental finding of single coronary artery in a patient with alcoholic cardiomyopathy presenting as acute heart failure. ( 28126699 )
2017
11
From the Cover: Alcohol Inhibition of the Enzymatic Activity of Glyceraldehyde 3-Phosphate Dehydrogenase Impairs Cardiac Glucose Utilization, Contributing to Alcoholic Cardiomyopathy. ( 28962519 )
2017
12
Alcoholic Cardiomyopathy: Translation Model. ( 28948557 )
2017
13
Etiology of alcoholic cardiomyopathy: Mitochondria, oxidative stress and apoptosis. ( 28606389 )
2017
14
Alcoholic Cardiomyopathy: Disrupted Protein Balance and Impaired Cardiomyocyte Contractility. ( 28425109 )
2017
15
Therapeutic effects of rapamycin on alcoholic cardiomyopathy. ( 28966668 )
2017
16
Extracorporeal membrane oxygenation for cardiogenic shock due to alcoholic cardiomyopathy: a long-term follow-up of 4 cases. ( 29281011 )
2017
17
Hydrogen sulfide alleviates myocardial fibrosis in mice with alcoholic cardiomyopathy by downregulating autophagy. ( 29039471 )
2017
18
Alcoholic cardiomyopathy: What is known and what is not known. ( 28647343 )
2017
19
Left Ventricular Strain and Rotation by 2-D Speckle Tracking Echocardiography Identify Early Alcoholic Cardiomyopathy. ( 27156014 )
2016
20
Alcoholic cardiomyopathy : The result of dosage and individual predisposition. ( 27582365 )
2016
21
Enzymes and signal pathways in the pathogenesis of alcoholic cardiomyopathy. ( 27418001 )
2016
22
NOX2 amplifies acetaldehyde-mediated cardiomyocyte mitochondrial dysfunction in alcoholic cardiomyopathy. ( 27624556 )
2016
23
Perioperative detection of alcoholic cardiomyopathy: cases and recommendations. ( 27720475 )
2016
24
[The comparative benchmark analysis of the methods used to verify etiology of myocarditis associated with alcoholic cardiomyopathy]. ( 26710509 )
2015
25
Malignant ventricular arrhythmias in alcoholic cardiomyopathy. ( 26188828 )
2015
26
Natural history and prognostic factors in alcoholic cardiomyopathy. ( 25458176 )
2015
27
Investigation of microRNA Expression Profiles Associated with Human Alcoholic Cardiomyopathy. ( 25791397 )
2015
28
Alcoholic cardiomyopathy: pathophysiologic insights. ( 24671642 )
2014
29
A case of heart failure due to alcoholic cardiomyopathy combined with acute pulmonary embolism. ( 25276392 )
2014
30
Alcoholic cardiomyopathy. ( 25228956 )
2014
31
Alcoholic Cardiomyopathy: Multigenic Changes Underlie Cardiovascular Dysfunction. ( 26478905 )
2014
32
Alcoholic cardiomyopathy. ( 24155001 )
2013
33
Quadri-chamber cardiac thrombi in alcoholic cardiomyopathy: a rare though ominous finding. ( 23708237 )
2013
34
Alcoholic cardiomyopathy and cardiovascular events - an insight from the Liptov region. ( 23731046 )
2013
35
Chronic alcohol intake-induced oxidative stress and apoptosis: role of CYP2E1 and calpain-1 in alcoholic cardiomyopathy. ( 21833537 )
2012
36
Sensitization to cross-reactive carbohydrate determinants in 2 patients with Hymenoptera venom allergy and alcoholic cardiomyopathy. ( 22901863 )
2012
37
Dilated alcoholic cardiomyopathy and incidental lymphoma occuring in a 56 year old man who was being managed for hypertensive heart disease in Enugu Nigeria--a rare finding. ( 22288332 )
2011
38
Tenascin-x facilitates myocardial fibrosis and cardiac remodeling through transforming growth factor-I^1 and peroxisome proliferator-activated receptor I^ in alcoholic cardiomyopathy. ( 21362339 )
2011
39
Alcoholic cardiomyopathy: a review. ( 21962423 )
2011
40
With computed tomography confirmed anterolateral left ventricular pseudoaneurysm in patient with dilatative alcoholic cardiomyopathy. ( 22933953 )
2011
41
Carnitine regulates myocardial metabolism by Peroxisome Proliferator-Activated Receptor-alpha (PPARalpha) in alcoholic cardiomyopathy. ( 21169901 )
2011
42
A dilated alcoholic cardiomyopathy. ( 19324436 )
2011
43
Evaluation of myocyte proliferation in alcoholic cardiomyopathy: telomerase enzyme activity (TERT) compared with Ki-67 expression. ( 21733836 )
2011
44
Functional proteomic analysis reveals sex-dependent differences in structural and energy-producing myocardial proteins in rat model of alcoholic cardiomyopathy. ( 21245415 )
2011
45
Increased myostatin activity and decreased myocyte proliferation in chronic alcoholic cardiomyopathy. ( 21463333 )
2011
46
WITHDRAWN: Oxidative stress-induced apoptosis is mediated by calpains in alcoholic cardiomyopathy. ( 21172724 )
2010
47
Alcoholic cardiomyopathy. ( 20308914 )
2010
48
Anticardiolipin antibodies associated with alcoholic cardiomyopathy. ( 18666184 )
2009
49
Alcoholic cardiomyopathy: acetaldehyde, insulin insensitization and ER stress. ( 18479704 )
2008
50
Diving-related pulmonary oedema as an unusual presentation of alcoholic cardiomyopathy. ( 22692709 )
2008

Variations for Alcoholic Cardiomyopathy

Expression for Alcoholic Cardiomyopathy

Search GEO for disease gene expression data for Alcoholic Cardiomyopathy.

Pathways for Alcoholic Cardiomyopathy

Pathways related to Alcoholic Cardiomyopathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.8 PPARA PPARG
2
Show member pathways
10.69 ACADM ALDH2
3 10.66 ACADM PPARA PPARG
4 10.37 ACADM PPARA

GO Terms for Alcoholic Cardiomyopathy

Cellular components related to Alcoholic Cardiomyopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II transcription factor complex GO:0090575 8.62 PPARA PPARG

Biological processes related to Alcoholic Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 9.73 ACADM PPARA PPARG SOAT2
2 heart development GO:0007507 9.69 ACADM PPARA PPARG
3 transcription initiation from RNA polymerase II promoter GO:0006367 9.63 CDK9 PPARA PPARG
4 regulation of blood pressure GO:0008217 9.58 ACE PPARG
5 response to estrogen GO:0043627 9.58 MSTN PPARG
6 steroid hormone mediated signaling pathway GO:0043401 9.57 PPARA PPARG
7 regulation of circadian rhythm GO:0042752 9.56 PPARA PPARG
8 intracellular receptor signaling pathway GO:0030522 9.55 PPARA PPARG
9 hormone-mediated signaling pathway GO:0009755 9.54 PPARA PPARG
10 regulation of lipid metabolic process GO:0019216 9.54 ACADM PPARA PPARG
11 response to cold GO:0009409 9.52 ACADM PPARG
12 response to starvation GO:0042594 9.49 ACADM PPARG
13 response to lipid GO:0033993 9.48 PPARA PPARG
14 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.4 PPARA PPARG
15 macrophage derived foam cell differentiation GO:0010742 9.32 PPARG SOAT2
16 positive regulation of fatty acid oxidation GO:0046321 9.26 PPARA PPARG
17 negative regulation of cholesterol storage GO:0010887 9.16 PPARA PPARG
18 negative regulation of sequestering of triglyceride GO:0010891 8.96 PPARA PPARG
19 negative regulation of receptor biosynthetic process GO:0010871 8.62 PPARA PPARG

Molecular functions related to Alcoholic Cardiomyopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.58 CDK9 PPARA PPARG
2 ligand-dependent nuclear receptor transcription coactivator activity GO:0030374 9.43 PPARA PPARG
3 steroid hormone receptor activity GO:0003707 9.37 PPARA PPARG
4 nuclear receptor activity GO:0004879 9.32 PPARA PPARG
5 transcription factor activity, RNA polymerase II transcription factor binding GO:0001076 9.26 PPARA PPARG
6 transcription factor activity, direct ligand regulated sequence-specific DNA binding GO:0098531 9.16 PPARA PPARG
7 transcription coactivator binding GO:0001223 8.96 CDK9 PPARA
8 drug binding GO:0008144 8.8 ACE PPARA PPARG

Sources for Alcoholic Cardiomyopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....