MCID: ALC010
MIFTS: 41

Alcoholic Cardiomyopathy

Categories: Cardiovascular diseases

Aliases & Classifications for Alcoholic Cardiomyopathy

MalaCards integrated aliases for Alcoholic Cardiomyopathy:

Name: Alcoholic Cardiomyopathy 12 15 17
Cardiomyopathy, Alcoholic 45 74
Dilated Cardiomyopathy Secondary to Alcohol 12
Alcohol-Induced Heart Muscle Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12935
ICD9CM 36 425.5
MeSH 45 D002310
NCIt 51 C53653
SNOMED-CT 69 83521008
ICD10 34 I42.6
UMLS 74 C0007192

Summaries for Alcoholic Cardiomyopathy

MalaCards based summary : Alcoholic Cardiomyopathy, also known as cardiomyopathy, alcoholic, is related to atrial standstill 1 and autosomal dominant non-syndromic intellectual disability 2. An important gene associated with Alcoholic Cardiomyopathy is PPARA (Peroxisome Proliferator Activated Receptor Alpha), and among its related pathways/superpathways are Nuclear Receptors in Lipid Metabolism and Toxicity and beta-Alanine metabolism (KEGG). The drugs Spironolactone and Natriuretic Agents have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and skeletal muscle, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 77 Alcoholic cardiomyopathy is a disease in which the chronic long-term abuse of alcohol (i.e., ethanol)... more...

Related Diseases for Alcoholic Cardiomyopathy

Diseases related to Alcoholic Cardiomyopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
# Related Disease Score Top Affiliating Genes
1 atrial standstill 1 10.4
2 autosomal dominant non-syndromic intellectual disability 2 10.1 PPARA PPARG
3 autosomal dominant non-syndromic intellectual disability 3 10.1 PPARA PPARG
4 rere-related disorders 10.1
5 idiopathic edema 10.0 ACE PPARA PPARG
6 lipodystrophy, familial partial, type 3 10.0 PPARA PPARG
7 lipid metabolism disorder 10.0 ACE PPARA PPARG
8 3-hydroxyacyl-coa dehydrogenase deficiency 10.0 ACADM PPARA PPARG
9 hypertrophic cardiomyopathy 10.0
10 acquired metabolic disease 10.0 ACE PPARA PPARG
11 arteriosclerosis 9.9 ACE PPARA PPARG
12 atrial fibrillation 9.9
13 myocarditis 9.9
14 arrhythmogenic right ventricular cardiomyopathy 9.8 ACADM PPARA PPARG
15 arteries, anomalies of 9.7
16 cardiac conduction defect 9.7
17 coronary artery anomaly 9.7
18 dilated cardiomyopathy 9.7
19 leber congenital amaurosis 9.7
20 liver disease 9.7
21 muscle disorders 9.7
22 lymphoma 9.7
23 heart disease 9.7
24 hemopericardium 9.7
25 hypertensive heart disease 9.7
26 pericardial effusion 9.7
27 myopathy 9.7
28 hypersplenism 9.7
29 pulmonary embolism 9.7
30 degos 'en cocarde' erythrokeratoderma 9.7
31 glyceraldehyde-3-phosphate dehydrogenase deficiency 9.7
32 cardiogenic shock 9.7
33 vascular disease 9.6 ACE CYBB PPARG

Comorbidity relations with Alcoholic Cardiomyopathy via Phenotypic Disease Network (PDN):


Alcohol Abuse Alcoholic Liver Cirrhosis
Familial Atrial Fibrillation Heart Disease
Ischemic Heart Disease Mitral Valve Disease
Respiratory Failure

Graphical network of the top 20 diseases related to Alcoholic Cardiomyopathy:



Diseases related to Alcoholic Cardiomyopathy

Symptoms & Phenotypes for Alcoholic Cardiomyopathy

MGI Mouse Phenotypes related to Alcoholic Cardiomyopathy:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.1 ACADM ACE ALDH2 CAPN1 CYBB MSTN
2 homeostasis/metabolism MP:0005376 10.02 ACADM ACE ALDH2 CAPN1 CYBB MSTN
3 immune system MP:0005387 9.87 ACE ALDH2 CAPN1 CYBB MSTN PPARA
4 adipose tissue MP:0005375 9.83 ACE CYBB MSTN PPARA PPARG
5 liver/biliary system MP:0005370 9.8 ACADM ACE ALDH2 MSTN PPARA PPARG
6 mortality/aging MP:0010768 9.76 ACADM ACE ALDH2 CAPN1 CYBB MSTN
7 muscle MP:0005369 9.43 ACADM ALDH2 CYBB MSTN PPARA PPARG
8 renal/urinary system MP:0005367 9.02 ACE ALDH2 CYBB MSTN PPARG

Drugs & Therapeutics for Alcoholic Cardiomyopathy

Drugs for Alcoholic Cardiomyopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
2 Natriuretic Agents Phase 4
3 Hormones Phase 4
4 Diuretics, Potassium Sparing Phase 4
5 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
6 diuretics Phase 4
7 Mineralocorticoid Receptor Antagonists Phase 4
8 Mineralocorticoids Phase 4
9 Hormone Antagonists Phase 4
10 Liver Extracts Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Trial Studying the Effects of Spironolactone on Heart and Skeletal Muscle Function in Chronic Alcoholics Suspended NCT00226109 Phase 4 spironolactone
2 Adapted Physical Activity Effect on Aerobic Function and in Patients in Pre Liver Transplantation Recruiting NCT02567591 Not Applicable

Search NIH Clinical Center for Alcoholic Cardiomyopathy

Cochrane evidence based reviews: cardiomyopathy, alcoholic

Genetic Tests for Alcoholic Cardiomyopathy

Anatomical Context for Alcoholic Cardiomyopathy

MalaCards organs/tissues related to Alcoholic Cardiomyopathy:

42
Heart, Liver, Skeletal Muscle, Testes

Publications for Alcoholic Cardiomyopathy

Articles related to Alcoholic Cardiomyopathy:

(show top 50) (show all 171)
# Title Authors Year
1
AIN-93 diet as an alternative model to Lieber-DeCarli diet for alcoholic cardiomyopathy. ( 31034614 )
2019
2
Effects of the (Pro)renin Receptor on Cardiac Remodeling and Function in a Rat Alcoholic Cardiomyopathy Model via the PRR-ERK1/2-NOX4 Pathway. ( 31049135 )
2019
3
Re: Left Ventricular Strain and Rotation by 2-D Speckle Tracking Echocardiography Identify Early Alcoholic Cardiomyopathy. ( 29033096 )
2018
4
Extracorporeal membrane oxygenation for cardiogenic shock due to alcoholic cardiomyopathy: a long-term follow-up of 4 cases. ( 29281011 )
2018
5
ALDH2 protects against alcoholic cardiomyopathy through a mechanism involving the p38 MAPK/CREB pathway and local renin-angiotensin system inhibition in cardiomyocytes. ( 29506687 )
2018
6
Alcohol puts the heart under pressure: Acetaldehyde activates a localized renin angiotensin aldosterone system within the myocardium in alcoholic cardiomyopathy. ( 29506696 )
2018
7
National, regional and global mortality due to alcoholic cardiomyopathy in 2015. ( 29535230 )
2018
8
Role of autophagy and regulatory mechanisms in alcoholic cardiomyopathy. ( 29555210 )
2018
9
Prognostic Impact and Predictors of Ejection Fraction Recovery in Patients With Alcoholic Cardiomyopathy. ( 29650446 )
2018
10
Expression Profiling of Circular RNAs and Micrornas in Heart Tissue of Mice with Alcoholic Cardiomyopathy. ( 29734191 )
2018
11
Alcoholic Cardiomyopathy: Is it Time for Genetic Testing? ( 29773158 )
2018
12
Atria Depolarization in Rats with Alcoholic Cardiomyopathy. ( 29790023 )
2018
13
The Prognostic Factors of Alcoholic Cardiomyopathy: A single-center cohort study. ( 30075591 )
2018
14
National trends in hospitalizations and outcomes in patients with alcoholic cardiomyopathy. ( 30178565 )
2018
15
Specific Features of Depolarization of the Left and Right Atria in Rats with Alcoholic Cardiomyopathy. ( 30225698 )
2018
16
Epac Proteins and Calmodulin as Possible Arrhythmogenesis Trigger in Alcoholic Cardiomyopathy. ( 30225708 )
2018
17
Histopathologic features of alcoholic cardiomyopathy compared with idiopathic dilated cardiomyopathy. ( 30278496 )
2018
18
Perioperative detection of alcoholic cardiomyopathy: cases and recommendations. ( 27720475 )
2017
19
Incidental finding of single coronary artery in a patient with alcoholic cardiomyopathy presenting as acute heart failure. ( 28126699 )
2017
20
Alcoholic Cardiomyopathy: Disrupted Protein Balance and Impaired Cardiomyocyte Contractility. ( 28425109 )
2017
21
Etiology of alcoholic cardiomyopathy: Mitochondria, oxidative stress and apoptosis. ( 28606389 )
2017
22
Alcoholic cardiomyopathy: What is known and what is not known. ( 28647343 )
2017
23
Alcoholic Cardiomyopathy: Translation Model. ( 28948557 )
2017
24
From the Cover: Alcohol Inhibition of the Enzymatic Activity of Glyceraldehyde 3-Phosphate Dehydrogenase Impairs Cardiac Glucose Utilization, Contributing to Alcoholic Cardiomyopathy. ( 28962519 )
2017
25
Therapeutic effects of rapamycin on alcoholic cardiomyopathy. ( 28966668 )
2017
26
Hydrogen sulfide alleviates myocardial fibrosis in mice with alcoholic cardiomyopathy by downregulating autophagy. ( 29039471 )
2017
27
Left Ventricular Strain and Rotation by 2-D Speckle Tracking Echocardiography Identify Early Alcoholic Cardiomyopathy. ( 27156014 )
2016
28
Enzymes and signal pathways in the pathogenesis of alcoholic cardiomyopathy. ( 27418001 )
2016
29
Alcoholic cardiomyopathy : The result of dosage and individual predisposition. ( 27582365 )
2016
30
NOX2 amplifies acetaldehyde-mediated cardiomyocyte mitochondrial dysfunction in alcoholic cardiomyopathy. ( 27624556 )
2016
31
Re-feeding syndrome and alcoholic cardiomyopathy: A case of interacting diagnoses. ( 30546674 )
2016
32
Natural history and prognostic factors in alcoholic cardiomyopathy. ( 25458176 )
2015
33
Investigation of microRNA expression profiles associated with human alcoholic cardiomyopathy. ( 25791397 )
2015
34
Malignant ventricular arrhythmias in alcoholic cardiomyopathy. ( 26188828 )
2015
35
[The comparative benchmark analysis of the methods used to verify etiology of myocarditis associated with alcoholic cardiomyopathy]. ( 26710509 )
2015
36
Alcoholic cardiomyopathy: pathophysiologic insights. ( 24671642 )
2014
37
Alcoholic cardiomyopathy. ( 25228956 )
2014
38
A case of heart failure due to alcoholic cardiomyopathy combined with acute pulmonary embolism. ( 25276392 )
2014
39
Alcoholic Cardiomyopathy: Multigenic Changes Underlie Cardiovascular Dysfunction. ( 26478905 )
2014
40
Quadri-chamber cardiac thrombi in alcoholic cardiomyopathy: a rare though ominous finding. ( 23708237 )
2013
41
Alcoholic cardiomyopathy and cardiovascular events - an insight from the Liptov region. ( 23731046 )
2013
42
Alcoholic cardiomyopathy. ( 24155001 )
2013
43
Chronic alcohol intake-induced oxidative stress and apoptosis: role of CYP2E1 and calpain-1 in alcoholic cardiomyopathy. ( 21833537 )
2012
44
Sensitization to cross-reactive carbohydrate determinants in 2 patients with Hymenoptera venom allergy and alcoholic cardiomyopathy. ( 22901863 )
2012
45
A dilated alcoholic cardiomyopathy. ( 19324436 )
2011
46
Carnitine regulates myocardial metabolism by Peroxisome Proliferator-Activated Receptor-alpha (PPARalpha) in alcoholic cardiomyopathy. ( 21169901 )
2011
47
Functional proteomic analysis reveals sex-dependent differences in structural and energy-producing myocardial proteins in rat model of alcoholic cardiomyopathy. ( 21245415 )
2011
48
Tenascin-x facilitates myocardial fibrosis and cardiac remodeling through transforming growth factor-β1 and peroxisome proliferator-activated receptor γ in alcoholic cardiomyopathy. ( 21362339 )
2011
49
Increased myostatin activity and decreased myocyte proliferation in chronic alcoholic cardiomyopathy. ( 21463333 )
2011
50
Evaluation of myocyte proliferation in alcoholic cardiomyopathy: telomerase enzyme activity (TERT) compared with Ki-67 expression. ( 21733836 )
2011

Variations for Alcoholic Cardiomyopathy

Expression for Alcoholic Cardiomyopathy

Search GEO for disease gene expression data for Alcoholic Cardiomyopathy.

Pathways for Alcoholic Cardiomyopathy

Pathways related to Alcoholic Cardiomyopathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.8 PPARA PPARG
2
Show member pathways
10.69 ACADM ALDH2
3 10.67 ACADM PPARA PPARG
4 10.37 ACADM PPARA

GO Terms for Alcoholic Cardiomyopathy

Biological processes related to Alcoholic Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 9.76 ACADM PPARA PPARG SOAT2
2 heart development GO:0007507 9.69 ACADM PPARA PPARG
3 fatty acid metabolic process GO:0006631 9.61 ACADM PPARA PPARG
4 regulation of blood pressure GO:0008217 9.58 ACE PPARG
5 steroid hormone mediated signaling pathway GO:0043401 9.57 PPARA PPARG
6 hormone-mediated signaling pathway GO:0009755 9.56 PPARA PPARG
7 regulation of circadian rhythm GO:0042752 9.55 PPARA PPARG
8 response to cold GO:0009409 9.54 ACADM PPARG
9 regulation of lipid metabolic process GO:0019216 9.54 ACADM PPARA PPARG
10 intracellular receptor signaling pathway GO:0030522 9.52 PPARA PPARG
11 response to starvation GO:0042594 9.49 ACADM PPARG
12 response to lipid GO:0033993 9.48 PPARA PPARG
13 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.4 PPARA PPARG
14 negative regulation of cholesterol storage GO:0010887 9.32 PPARA PPARG
15 macrophage derived foam cell differentiation GO:0010742 9.26 PPARG SOAT2
16 positive regulation of fatty acid oxidation GO:0046321 9.16 PPARA PPARG
17 negative regulation of sequestering of triglyceride GO:0010891 8.96 PPARA PPARG
18 negative regulation of receptor biosynthetic process GO:0010871 8.62 PPARA PPARG

Molecular functions related to Alcoholic Cardiomyopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear receptor transcription coactivator activity GO:0030374 9.37 PPARA PPARG
2 steroid hormone receptor activity GO:0003707 9.32 PPARA PPARG
3 nuclear receptor activity GO:0004879 9.26 PPARA PPARG
4 RNA polymerase II repressing transcription factor binding GO:0001103 9.16 PPARA PPARG
5 fatty acid binding GO:0005504 8.96 PPARA PPARG
6 drug binding GO:0008144 8.8 ACE PPARA PPARG

Sources for Alcoholic Cardiomyopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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