MCID: ALC010
MIFTS: 42

Alcoholic Cardiomyopathy

Categories: Cardiovascular diseases, Muscle diseases

Aliases & Classifications for Alcoholic Cardiomyopathy

MalaCards integrated aliases for Alcoholic Cardiomyopathy:

Name: Alcoholic Cardiomyopathy 12 15 17 32
Cardiomyopathy, Alcoholic 44 70
Dilated Cardiomyopathy Secondary to Alcohol 12
Alcohol-Induced Heart Muscle Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12935
ICD9CM 34 425.5
MeSH 44 D002310
NCIt 50 C53653
SNOMED-CT 67 83521008
ICD10 32 I42.6
UMLS 70 C0007192

Summaries for Alcoholic Cardiomyopathy

MalaCards based summary : Alcoholic Cardiomyopathy, also known as cardiomyopathy, alcoholic, is related to alcohol use disorder and alcohol dependence. An important gene associated with Alcoholic Cardiomyopathy is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are PPAR signaling pathway and Nuclear Receptors in Lipid Metabolism and Toxicity. The drugs Spironolactone and Mineralocorticoids have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and skeletal muscle, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 73 Alcoholic cardiomyopathy is a disease in which the chronic long-term heavy use of alcohol (i.e.,... more...

Related Diseases for Alcoholic Cardiomyopathy

Diseases related to Alcoholic Cardiomyopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)
# Related Disease Score Top Affiliating Genes
1 alcohol use disorder 30.6 CYP2E1 ALDH2 ADH1B
2 alcohol dependence 30.4 CYP2E1 ALDH2 ADH1B ACE
3 left bundle branch hemiblock 30.2 REN ACE
4 hypertensive heart disease 29.9 REN PPARA MSTN ACE
5 fatty liver disease 29.8 PPARG PPARA CYP2E1 ACADM
6 cardiac arrest 29.6 TTN REN ACE
7 lipoprotein quantitative trait locus 29.4 TTN REN PPARG PPARA ACE
8 heart disease 29.2 TTN REN PPARG PPARA MSTN AVP
9 liver cirrhosis 29.2 REN PPARG CYP2E1 AVP ALDH2 ADH1B
10 atrial standstill 1 10.9
11 dilated cardiomyopathy 10.5
12 cardiac conduction defect 10.4
13 alzheimer disease 11 10.4 PPARG PPARA
14 renal artery obstruction 10.3 REN ACE
15 hypoaldosteronism 10.3 REN ACE
16 orthostatic proteinuria 10.3 REN ACE
17 hypertension, diastolic 10.3 REN ACE
18 sister chromatid exchange, frequency of 10.3 CYP2E1 ALDH2
19 cholesterol embolism 10.3 REN ACE
20 hypertensive encephalopathy 10.3 REN ACE
21 kidney papillary necrosis 10.3 REN ACE
22 idiopathic edema 10.3 PPARG PPARA ACE
23 generalized atherosclerosis 10.3 REN ACE
24 potter's syndrome 10.3 REN ACE
25 maturity-onset diabetes of the young, type 1 10.3 PPARG PPARA ACE
26 severe nonproliferative diabetic retinopathy 10.2 REN ACE
27 congestive heart failure 10.2
28 kidney hypertrophy 10.2 REN ACE
29 pulmonary valve insufficiency 10.2 REN ACE
30 hypertensive retinopathy 10.2 REN ACE
31 familial hyperlipidemia 10.2 PPARG PPARA ACE
32 fibromuscular dysplasia 10.2 REN ACE
33 renal hypertension 10.2 REN CYBB ACE
34 renal artery disease 10.2 REN ACE
35 abdominal obesity-metabolic syndrome 1 10.2 PPARG PPARA ACADM
36 avascular necrosis 10.2 ALDH2 ADH1B
37 supine hypotensive syndrome 10.2 REN AVP
38 adult syndrome 10.2 REN PPARG PPARA
39 pure autonomic failure 10.2 REN ACE
40 lipid storage disease 10.2 PPARG PPARA CYP2E1
41 non-alcoholic steatohepatitis 10.2 PPARG PPARA CYP2E1
42 cranial nerve palsy 10.2 AVP ACE
43 benign essential hypertension 10.1 REN AVP
44 myopathy 10.1
45 myocarditis 10.1
46 inappropriate adh syndrome 10.1 REN AVP ACE
47 hepatorenal syndrome 10.1 REN AVP ACE
48 cardiac tamponade 10.1 REN ACE
49 mineral metabolism disease 10.1 REN AVP ACE
50 lipid metabolism disorder 10.1 PPARG PPARA ACE

Comorbidity relations with Alcoholic Cardiomyopathy via Phenotypic Disease Network (PDN):


Alcohol Use Disorder Alcoholic Liver Cirrhosis
Familial Atrial Fibrillation Heart Disease
Mitral Valve Disease Respiratory Failure

Graphical network of the top 20 diseases related to Alcoholic Cardiomyopathy:



Diseases related to Alcoholic Cardiomyopathy

Symptoms & Phenotypes for Alcoholic Cardiomyopathy

MGI Mouse Phenotypes related to Alcoholic Cardiomyopathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.11 ACADM ACE ALDH2 CYBB CYP2E1 LACTB2
2 homeostasis/metabolism MP:0005376 10.1 ACADM ACE ALDH2 AVP CYBB CYP2E1
3 mortality/aging MP:0010768 9.93 ACADM ACE ALDH2 AVP CYBB CYP2E1
4 liver/biliary system MP:0005370 9.86 ACADM ACE ALDH2 CYP2E1 LACTB2 MSTN
5 muscle MP:0005369 9.56 ACADM ALDH2 CYBB MSTN PPARA PPARG
6 renal/urinary system MP:0005367 9.23 ACE ALDH2 AVP CYBB MSTN PPARA

Drugs & Therapeutics for Alcoholic Cardiomyopathy

Drugs for Alcoholic Cardiomyopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
2 Mineralocorticoids Phase 4
3 Hormone Antagonists Phase 4
4 Mineralocorticoid Receptor Antagonists Phase 4
5 diuretics Phase 4
6 Hormones Phase 4
7 Diuretics, Potassium Sparing Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Spironolactone Treatment on Heart- and Skeletal Muscle in Chronic Alcoholics Suspended NCT00226109 Phase 4 spironolactone

Search NIH Clinical Center for Alcoholic Cardiomyopathy

Cochrane evidence based reviews: cardiomyopathy, alcoholic

Genetic Tests for Alcoholic Cardiomyopathy

Anatomical Context for Alcoholic Cardiomyopathy

MalaCards organs/tissues related to Alcoholic Cardiomyopathy:

40
Heart, Liver, Skeletal Muscle, Brain, Cardiac Myocytes, Spinal Cord

Publications for Alcoholic Cardiomyopathy

Articles related to Alcoholic Cardiomyopathy:

(show top 50) (show all 557)
# Title Authors PMID Year
1
The alcohol-induced cardiomyopathy: A cardiovascular magnetic resonance characterization. 61
33545263 2021
2
Alcohol and melatonin. 61
33761823 2021
3
The Proarrhythmic Conundrum of Alcohol Intake: Alcohol-Induced Proarrhythmia. 61
33762184 2021
4
The protective effect of fibroblast growth factor-21 in alcoholic cardiomyopathy: a role in protecting cardiac mitochondrial function. 61
33125701 2021
5
FGF21: a promising therapeutic agent for alcoholic cardiomyopathy?†. 61
33630303 2021
6
Astaxanthin attenuates alcoholic cardiomyopathy via inhibition of endoplasmic reticulum stress-mediated cardiac apoptosis. 61
33352188 2021
7
Deletion of the E3 ubiquitin ligase, Parkin, exacerbates chronic alcohol intake-induced cardiomyopathy through an Ambra1-dependent mechanism. 61
33300167 2021
8
Global, Regional, and National Burden of Myocarditis and Cardiomyopathy, 1990-2017. 61
33644130 2021
9
Accelerated FASTK mRNA degradation induced by oxidative stress is responsible for the destroyed myocardial mitochondrial gene expression and respiratory function in alcoholic cardiomyopathy. 61
33197770 2021
10
Schisandrin B Protects against Acute Ethanol-Induced Cardiac Injury by Downregulating Autophagy via the NOX4/ROS Pathway. 61
33486482 2021
11
Cardiovascular Consequences of Excessive Alcohol Drinking via Electrocardiogram: A Systematic Review. 61
33646717 2021
12
Correction: Clinical profile and prognostic factors of alcoholic cardiomyopathy in tribal and non-tribal population. 61
33303621 2020
13
Clinical profile and prognostic factors of alcoholic cardiomyopathy in tribal and non-tribal population. 61
33234711 2020
14
Cardiac Mitochondrial PTEN-L determines cell fate between apoptosis and survival during chronic alcohol consumption. 61
32591959 2020
15
Upper Thoracic Spine Synovial Cyst Resulting in Paraplegia Following Transient Hypotension. 61
32963911 2020
16
Characterization of myocardial oxidative metabolism and myocardial external efficiency in high-risk alcohol cardiotoxicity and alcoholic cardiomyopathy via dynamic 11C-Acetate positron emission tomography. 61
32557237 2020
17
Characteristics of subjects with alcoholic cardiomyopathy and sudden cardiac death. 61
31551291 2020
18
Burden of arrhythmia and electrophysiologic procedures in alcoholic cardiomyopathy hospitalizations. 61
32057474 2020
19
A method for establishing the electrophysiological model of alcoholic cardiomyopathy. 61
32879062 2020
20
[Differences by sex and income level in mortality from causes directly related to alcohol in Navarre, 1993-2017]. 61
31999271 2020
21
The Effects of Ethanol on the Heart: Alcoholic Cardiomyopathy. 61
32098364 2020
22
Expression of microRNAs (133b and 138) and Correlation with Echocardiographic Parameters in Patients with Alcoholic Cardiomyopathy. 61
31333145 2020
23
Effects of Alcohol on the Cardiovascular System in Women. 61
32766021 2020
24
Valsartan inhibits RhoA-ROCK2-MYL pathway in rat model of alcoholic cardiomyopathy. 61
31777538 2019
25
Research Progress and Forensic Identification of Alcoholic Cardiomyopathy. 61
31970961 2019
26
(Pro)renin Receptor is Involved in Myocardial Damage in Alcoholic Cardiomyopathy. 61
31498445 2019
27
[Clinical classification and characteristics of alcoholic myocardial injury]. 61
31694119 2019
28
Alcohol use disorders and the heart. 61
31309639 2019
29
Contemporary Appraisal of Sex Differences in Prevalence, Correlates, and Outcomes of Alcoholic Cardiomyopathy. 61
31206165 2019
30
Mortality from Alcoholic Cardiomyopathy: Exploring the Gap between Estimated and Civil Registry Data. 61
31370237 2019
31
AIN-93 Diet as an Alternative Model to Lieber-DeCarli Diet for Alcoholic Cardiomyopathy. 61
31034614 2019
32
[Chronic right ventricular failure in a patient with diffuse toxic goiter and alcoholic cirrhosis of the liver: case description]. 61
31340750 2019
33
Thiamine and Heart Failure: Challenging Cases of Modern-Day Cardiac Beriberi. 61
31193878 2019
34
MicroRNA‑186‑5p is expressed highly in ethanol‑induced cardiomyocytes and regulates apoptosis via the target gene XIAP. 61
30816481 2019
35
Atorvastatin reduces alcohol-induced endoplasmic reticulum stress in AC16 cardiomyocytes. 61
30160187 2019
36
Cirrhotic cardiomyopathy: the liver affects the heart. 61
30785477 2019
37
Effects of the (Pro)renin Receptor on Cardiac Remodeling and Function in a Rat Alcoholic Cardiomyopathy Model via the PRR-ERK1/2-NOX4 Pathway. 61
31049135 2019
38
National trends in hospitalizations and outcomes in patients with alcoholic cardiomyopathy. 61
30178565 2018
39
National, regional and global mortality due to alcoholic cardiomyopathy in 2015. 61
29535230 2018
40
Epac Proteins and Calmodulin as Possible Arrhythmogenesis Trigger in Alcoholic Cardiomyopathy. 61
30225708 2018
41
Specific Features of Depolarization of the Left and Right Atria in Rats with Alcoholic Cardiomyopathy. 61
30225698 2018
42
Histopathologic features of alcoholic cardiomyopathy compared with idiopathic dilated cardiomyopathy. 61
30278496 2018
43
The Prognostic Factors of Alcoholic Cardiomyopathy: A single-center cohort study. 61
30075591 2018
44
Prognostic Impact and Predictors of Ejection Fraction Recovery in Patients With Alcoholic Cardiomyopathy. 61
29650446 2018
45
Ethanol-induced cardiomyocyte toxicity implicit autophagy and NFkB transcription factor. 61
29679641 2018
46
Role of autophagy and regulatory mechanisms in alcoholic cardiomyopathy. 61
29555210 2018
47
Genetic Etiology for Alcohol-Induced Cardiac Toxicity. 61
29773157 2018
48
Alcoholic Cardiomyopathy: Is it Time for Genetic Testing? 61
29773158 2018
49
Chronic Ethanol Administration Prevents Compensatory Cardiac Hypertrophy in Pressure Overload. 61
29846943 2018
50
ALDH2 protects against alcoholic cardiomyopathy through a mechanism involving the p38 MAPK/CREB pathway and local renin-angiotensin system inhibition in cardiomyocytes. 61
29506687 2018

Variations for Alcoholic Cardiomyopathy

Expression for Alcoholic Cardiomyopathy

Search GEO for disease gene expression data for Alcoholic Cardiomyopathy.

Pathways for Alcoholic Cardiomyopathy

GO Terms for Alcoholic Cardiomyopathy

Biological processes related to Alcoholic Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.97 CYP2E1 CYBB ALDH2 ADH1B ACADM
2 response to drug GO:0042493 9.85 REN PPARG CYP2E1 CYBB
3 response to organic cyclic compound GO:0014070 9.74 PPARG PPARA AVP
4 regulation of lipid metabolic process GO:0019216 9.67 PPARG PPARA ACADM
5 fatty acid metabolic process GO:0006631 9.67 PPARG PPARA CYP2E1 ACADM
6 organic acid metabolic process GO:0006082 9.58 CYP2E1 ACADM
7 regulation of blood pressure GO:0008217 9.58 REN PPARG ACE
8 response to lipid GO:0033993 9.56 PPARG PPARA
9 amyloid-beta metabolic process GO:0050435 9.54 REN ACE
10 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.52 PPARG PPARA
11 positive regulation of systemic arterial blood pressure GO:0003084 9.51 AVP ACE
12 ethanol oxidation GO:0006069 9.48 ALDH2 ADH1B
13 angiotensin maturation GO:0002003 9.46 REN ACE
14 negative regulation of cholesterol storage GO:0010887 9.43 PPARG PPARA
15 hormone-mediated signaling pathway GO:0009755 9.43 REN PPARG PPARA
16 positive regulation of fatty acid oxidation GO:0046321 9.32 PPARG PPARA
17 positive regulation of fatty acid metabolic process GO:0045923 9.16 PPARG PPARA
18 negative regulation of sequestering of triglyceride GO:0010891 8.96 PPARG PPARA
19 response to ethanol GO:0045471 8.92 PPARA MSTN CYP2E1 AVP

Molecular functions related to Alcoholic Cardiomyopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.02 CYP2E1 CYBB ALDH2 ADH1B ACADM

Sources for Alcoholic Cardiomyopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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