MCID: ALC010
MIFTS: 42

Alcoholic Cardiomyopathy

Categories: Cardiovascular diseases

Aliases & Classifications for Alcoholic Cardiomyopathy

MalaCards integrated aliases for Alcoholic Cardiomyopathy:

Name: Alcoholic Cardiomyopathy 12 15 17 32
Cardiomyopathy, Alcoholic 43 71
Dilated Cardiomyopathy Secondary to Alcohol 12
Alcohol-Induced Heart Muscle Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12935
ICD9CM 34 425.5
MeSH 43 D002310
NCIt 49 C53653
SNOMED-CT 67 83521008
ICD10 32 I42.6
UMLS 71 C0007192

Summaries for Alcoholic Cardiomyopathy

MalaCards based summary : Alcoholic Cardiomyopathy, also known as cardiomyopathy, alcoholic, is related to alcohol use disorder and alcohol dependence. An important gene associated with Alcoholic Cardiomyopathy is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are Fatty Acyl-CoA Biosynthesis and superpathway of tryptophan utilization. The drugs Spironolactone and Hormone Antagonists have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and skeletal muscle, and related phenotypes are cardiovascular system and adipose tissue

Wikipedia : 74 Alcoholic cardiomyopathy is a disease in which the chronic long-term abuse of alcohol (i.e., ethanol)... more...

Related Diseases for Alcoholic Cardiomyopathy

Diseases related to Alcoholic Cardiomyopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 alcohol use disorder 30.6 CYP2E1 ALDH2 ADH1B
2 alcohol dependence 30.0 CYP2E1 ALDH2 ADH6 ADH1B ACE
3 hypertensive heart disease 29.7 REN PPARA MSTN ACE
4 heart disease 29.3 REN PPARG PPARA MSTN AVP ACE
5 liver cirrhosis 29.0 REN CYP2E1 AVP ALDH2 ADH1B
6 atrial standstill 1 11.0
7 non-alcoholic steatohepatitis 10.4 PPARG PPARA
8 dilated cardiomyopathy 10.4
9 lipodystrophy, familial partial, type 3 10.4 PPARG PPARA
10 hypoaldosteronism 10.4 REN ACE
11 renal artery obstruction 10.4 REN ACE
12 orthostatic proteinuria 10.4 REN ACE
13 idiopathic edema 10.3 PPARG PPARA ACE
14 sister chromatid exchange, frequency of 10.3 CYP2E1 ALDH2
15 hypertension, diastolic 10.3 REN ACE
16 cholesterol embolism 10.3 REN ACE
17 hypertrophic cardiomyopathy 10.3
18 kidney papillary necrosis 10.3 REN ACE
19 generalized atherosclerosis 10.3 REN ACE
20 prediabetes syndrome 10.3 PPARG PPARA ACE
21 potter's syndrome 10.3 REN ACE
22 congestive heart failure 10.3
23 hypertensive encephalopathy 10.3 REN ACE
24 abdominal obesity-metabolic syndrome quantitative trait locus 2 10.3 PPARG PPARA
25 severe nonproliferative diabetic retinopathy 10.3 REN ACE
26 malignant essential hypertension 10.3 REN ACE
27 cardiac conduction defect 10.3
28 fibromuscular dysplasia 10.3 REN ACE
29 abdominal obesity-metabolic syndrome 1 10.3 PPARG PPARA ACADM
30 kidney hypertrophy 10.3 REN ACE
31 familial hyperlipidemia 10.2 PPARG PPARA ACE
32 hypertensive retinopathy 10.2 REN ACE
33 diastolic heart failure 10.2 REN CYBB ACE
34 apnea, obstructive sleep 10.2 REN CYBB ACE
35 renal hypertension 10.2 REN CYBB ACE
36 pure autonomic failure 10.2 REN ACE
37 endocrine pancreas disease 10.2 REN PPARG PPARA
38 lipid storage disease 10.2 PPARG PPARA CYP2E1
39 renal artery disease 10.1 REN ACE
40 myocarditis 10.1
41 methanol poisoning 10.1 CYP2E1 ALDH2 ADH1B
42 placenta disease 10.1 REN MIR512-1 ACADM
43 alcoholic pancreatitis 10.1 CYP2E1 ALDH2 ADH1B
44 fetal alcohol syndrome 10.1 CYP2E1 ALDH2 ADH1B
45 coronary heart disease 1 10.1
46 choline deficiency disease 10.1 PPARA CYP2E1
47 alcoholic liver cirrhosis 10.1 CYP2E1 ALDH2 ADH1B
48 inherited metabolic disorder 10.1 REN PPARG PPARA ACE
49 overnutrition 10.0 REN PPARG PPARA ACE
50 myopathy 10.0

Comorbidity relations with Alcoholic Cardiomyopathy via Phenotypic Disease Network (PDN):


Alcoholic Liver Cirrhosis Familial Atrial Fibrillation
Heart Disease Mitral Valve Disease
Respiratory Failure

Graphical network of the top 20 diseases related to Alcoholic Cardiomyopathy:



Diseases related to Alcoholic Cardiomyopathy

Symptoms & Phenotypes for Alcoholic Cardiomyopathy

MGI Mouse Phenotypes related to Alcoholic Cardiomyopathy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.96 ACADM ACE ALDH2 CYBB CYP2E1 LACTB2
2 adipose tissue MP:0005375 9.8 ACE CYBB LACTB2 MSTN PPARA PPARG
3 liver/biliary system MP:0005370 9.76 ACADM ACE ALDH2 CYP2E1 LACTB2 MSTN
4 muscle MP:0005369 9.5 ACADM ALDH2 CYBB MSTN PPARA PPARG
5 renal/urinary system MP:0005367 9.23 ACE ALDH2 AVP CYBB MSTN PPARA

Drugs & Therapeutics for Alcoholic Cardiomyopathy

Drugs for Alcoholic Cardiomyopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
2 Hormone Antagonists Phase 4
3 Mineralocorticoids Phase 4
4 Mineralocorticoid Receptor Antagonists Phase 4
5 Natriuretic Agents Phase 4
6 Diuretics, Potassium Sparing Phase 4
7 diuretics Phase 4
8 Hormones Phase 4
9 Liver Extracts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Spironolactone Treatment on Heart- and Skeletal Muscle in Chronic Alcoholics Suspended NCT00226109 Phase 4 spironolactone
2 Adapted Physical Activity Effect on Aerobic Function and in Patients in Pre Liver Transplantation Recruiting NCT02567591

Search NIH Clinical Center for Alcoholic Cardiomyopathy

Cochrane evidence based reviews: cardiomyopathy, alcoholic

Genetic Tests for Alcoholic Cardiomyopathy

Anatomical Context for Alcoholic Cardiomyopathy

MalaCards organs/tissues related to Alcoholic Cardiomyopathy:

40
Heart, Liver, Skeletal Muscle, Kidney, Pituitary, Testes, Brain

Publications for Alcoholic Cardiomyopathy

Articles related to Alcoholic Cardiomyopathy:

(show top 50) (show all 537)
# Title Authors PMID Year
1
[Differences by sex and income level in mortality from causes directly related to alcohol in Navarre, 1993-2017]. 61
31999271 2020
2
Research Progress and Forensic Identification of Alcoholic Cardiomyopathy. 61
31970961 2019
3
Valsartan inhibits RhoA-ROCK2-MYL pathway in rat model of alcoholic cardiomyopathy. 61
31777538 2019
4
(Pro)renin Receptor is Involved in Myocardial Damage in Alcoholic Cardiomyopathy. 61
31498445 2019
5
[Clinical classification and characteristics of alcoholic myocardial injury]. 61
31694119 2019
6
Alcohol use disorders and the heart. 61
31309639 2019
7
Characteristics of subjects with alcoholic cardiomyopathy and sudden cardiac death. 61
31551291 2019
8
AIN-93 Diet as an Alternative Model to Lieber-DeCarli Diet for Alcoholic Cardiomyopathy. 61
31034614 2019
9
Contemporary Appraisal of Sex Differences in Prevalence, Correlates, and Outcomes of Alcoholic Cardiomyopathy. 61
31206165 2019
10
Expression of microRNAs (133b and 138) and Correlation with Echocardiographic Parameters in Patients with Alcoholic Cardiomyopathy. 61
31333145 2019
11
Mortality from Alcoholic Cardiomyopathy: Exploring the Gap between Estimated and Civil Registry Data. 61
31370237 2019
12
[Chronic right ventricular failure in a patient with diffuse toxic goiter and alcoholic cirrhosis of the liver: case description]. 61
31340750 2019
13
Thiamine and Heart Failure: Challenging Cases of Modern-Day Cardiac Beriberi. 61
31193878 2019
14
MicroRNA‑186‑5p is expressed highly in ethanol‑induced cardiomyocytes and regulates apoptosis via the target gene XIAP. 61
30816481 2019
15
Atorvastatin reduces alcohol-induced endoplasmic reticulum stress in AC16 cardiomyocytes. 61
30160187 2019
16
Cirrhotic cardiomyopathy: the liver affects the heart. 61
30785477 2019
17
Effects of the (Pro)renin Receptor on Cardiac Remodeling and Function in a Rat Alcoholic Cardiomyopathy Model via the PRR-ERK1/2-NOX4 Pathway. 61
31049135 2019
18
National trends in hospitalizations and outcomes in patients with alcoholic cardiomyopathy. 61
30178565 2018
19
National, regional and global mortality due to alcoholic cardiomyopathy in 2015. 61
29535230 2018
20
Epac Proteins and Calmodulin as Possible Arrhythmogenesis Trigger in Alcoholic Cardiomyopathy. 61
30225708 2018
21
Specific Features of Depolarization of the Left and Right Atria in Rats with Alcoholic Cardiomyopathy. 61
30225698 2018
22
Histopathologic features of alcoholic cardiomyopathy compared with idiopathic dilated cardiomyopathy. 61
30278496 2018
23
The Prognostic Factors of Alcoholic Cardiomyopathy: A single-center cohort study. 61
30075591 2018
24
Prognostic Impact and Predictors of Ejection Fraction Recovery in Patients With Alcoholic Cardiomyopathy. 61
29650446 2018
25
Ethanol-induced cardiomyocyte toxicity implicit autophagy and NFkB transcription factor. 61
29679641 2018
26
Role of autophagy and regulatory mechanisms in alcoholic cardiomyopathy. 61
29555210 2018
27
Alcoholic Cardiomyopathy: Is it Time for Genetic Testing? 61
29773158 2018
28
Genetic Etiology for Alcohol-Induced Cardiac Toxicity. 61
29773157 2018
29
Chronic Ethanol Administration Prevents Compensatory Cardiac Hypertrophy in Pressure Overload. 61
29846943 2018
30
ALDH2 protects against alcoholic cardiomyopathy through a mechanism involving the p38 MAPK/CREB pathway and local renin-angiotensin system inhibition in cardiomyocytes. 61
29506687 2018
31
Alcohol puts the heart under pressure: Acetaldehyde activates a localized renin angiotensin aldosterone system within the myocardium in alcoholic cardiomyopathy. 61
29506696 2018
32
Extracorporeal membrane oxygenation for cardiogenic shock due to alcoholic cardiomyopathy: a long-term follow-up of 4 cases. 61
29281011 2018
33
Atria Depolarization in Rats with Alcoholic Cardiomyopathy. 61
29790023 2018
34
CYP2J2-derived EETs attenuated ethanol-induced myocardial dysfunction through inducing autophagy and reducing apoptosis. 61
29427791 2018
35
Comparison among Reconstruction Algorithms for Quantitative Analysis of 11C-Acetate Cardiac PET Imaging. 61
29681784 2018
36
Re: Left Ventricular Strain and Rotation by 2-D Speckle Tracking Echocardiography Identify Early Alcoholic Cardiomyopathy. 61
29033096 2018
37
Expression Profiling of Circular RNAs and Micrornas in Heart Tissue of Mice with Alcoholic Cardiomyopathy. 61
29734191 2018
38
Hydrogen sulfide alleviates myocardial fibrosis in mice with alcoholic cardiomyopathy by downregulating autophagy. 61
29039471 2017
39
Diagnostic and therapeutic challenge of heart failure after liver transplant: Case series. 61
29312528 2017
40
From the Cover: Alcohol Inhibition of the Enzymatic Activity of Glyceraldehyde 3-Phosphate Dehydrogenase Impairs Cardiac Glucose Utilization, Contributing to Alcoholic Cardiomyopathy. 61
28962519 2017
41
Therapeutic effects of rapamycin on alcoholic cardiomyopathy. 61
28966668 2017
42
Alcoholic cardiomyopathy: What is known and what is not known. 61
28647343 2017
43
Alcoholic Cardiomyopathy: Translation Model. 61
28948557 2017
44
Harm reduction-a systematic review on effects of alcohol reduction on physical and mental symptoms. 61
27353220 2017
45
Alcoholic Cardiomyopathy: Disrupted Protein Balance and Impaired Cardiomyocyte Contractility. 61
28425109 2017
46
Etiology of alcoholic cardiomyopathy: Mitochondria, oxidative stress and apoptosis. 61
28606389 2017
47
Tildrakizumab versus placebo or etanercept for chronic plaque psoriasis (reSURFACE 1 and reSURFACE 2): results from two randomised controlled, phase 3 trials. 61
28596043 2017
48
Evidence of Altered Mitochondrial Protein Expression After Chronic Ethanol Consumption in the Aged Estrogen-Deficient Female Rat Heart. 61
28543099 2017
49
Quantifying the contribution of alcohol to cardiomyopathy: A systematic review. 61
28599715 2017
50
Intracavitary ethanol ablation for the management of uterine hemorrhage refractory to uterine artery embolization. 61
28242556 2017

Variations for Alcoholic Cardiomyopathy

Expression for Alcoholic Cardiomyopathy

Search GEO for disease gene expression data for Alcoholic Cardiomyopathy.

Pathways for Alcoholic Cardiomyopathy

Pathways related to Alcoholic Cardiomyopathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.19 ALDH2 ADH6 ADH1B ACADM
2
Show member pathways
11.51 ALDH2 ADH6 ADH1B
3 11.38 PPARG PPARA ACADM
4 10.98 PPARG PPARA CYP2E1
5
Show member pathways
10.82 ALDH2 ADH6 ADH1B
6
Show member pathways
10.41 CYP2E1 ADH1B
7
Show member pathways
10.31 ALDH2 ADH6 ADH1B
8
Show member pathways
9.98 CYP2E1 ALDH2 ADH1B

GO Terms for Alcoholic Cardiomyopathy

Biological processes related to Alcoholic Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.88 CYP2E1 CYBB ALDH2 ADH6 ADH1B ACADM
2 response to drug GO:0042493 9.86 REN PPARG CYP2E1 CYBB
3 regulation of lipid metabolic process GO:0019216 9.71 PPARG PPARA ACADM
4 fatty acid metabolic process GO:0006631 9.67 PPARG PPARA CYP2E1 ACADM
5 regulation of blood pressure GO:0008217 9.63 REN PPARG ACE
6 organic acid metabolic process GO:0006082 9.57 CYP2E1 ACADM
7 amyloid-beta metabolic process GO:0050435 9.55 REN ACE
8 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.52 PPARG PPARA
9 angiotensin maturation GO:0002003 9.51 REN ACE
10 hormone-mediated signaling pathway GO:0009755 9.5 REN PPARG PPARA
11 positive regulation of systemic arterial blood pressure GO:0003084 9.49 AVP ACE
12 negative regulation of cholesterol storage GO:0010887 9.48 PPARG PPARA
13 positive regulation of fatty acid oxidation GO:0046321 9.43 PPARG PPARA
14 negative regulation of sequestering of triglyceride GO:0010891 9.26 PPARG PPARA
15 response to ethanol GO:0045471 9.26 MSTN CYP2E1 AVP ADH6
16 negative regulation of receptor biosynthetic process GO:0010871 9.16 PPARG PPARA
17 ethanol oxidation GO:0006069 8.8 ALDH2 ADH6 ADH1B

Molecular functions related to Alcoholic Cardiomyopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 9.63 PPARG PPARA LACTB2 ADH6 ADH1B ACE
2 drug binding GO:0008144 9.43 PPARG PPARA ACE
3 retinol dehydrogenase activity GO:0004745 9.32 ADH6 ADH1B
4 oxidoreductase activity GO:0016491 9.1 CYP2E1 CYBB ALDH2 ADH6 ADH1B ACADM
5 alcohol dehydrogenase activity, zinc-dependent GO:0004024 8.96 ADH6 ADH1B

Sources for Alcoholic Cardiomyopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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