MCID: ALC006
MIFTS: 62

Alcoholic Hepatitis

Categories: Endocrine diseases, Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Alcoholic Hepatitis

MalaCards integrated aliases for Alcoholic Hepatitis:

Name: Alcoholic Hepatitis 39 12 77 15
Acute Alcoholic Liver Disease 12 74
Acute Alcoholic Hepatitis 12 56
Hepatitis, Alcoholic 17 74
Hepatitis Alcoholic 56

Classifications:



External Ids:

Disease Ontology 12 DOID:12351
ICD9CM 36 571.1
NCIt 51 C34352
SNOMED-CT 69 9953008
ICD10 34 K70.1

Summaries for Alcoholic Hepatitis

MalaCards based summary : Alcoholic Hepatitis, also known as acute alcoholic liver disease, is related to fatty liver disease and hepatitis. An important gene associated with Alcoholic Hepatitis is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways are TGF-Beta Pathway and Cytokine Signaling in Immune system. The drugs Pentoxifylline and Ethanol have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and neutrophil, and related phenotypes are homeostasis/metabolism and liver/biliary system

Wikipedia : 77 Alcoholic hepatitis is hepatitis (inflammation of the liver) due to excessive intake of alcohol. It is... more...

Related Diseases for Alcoholic Hepatitis

Diseases related to Alcoholic Hepatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 347)
# Related Disease Score Top Affiliating Genes
1 fatty liver disease 32.0 CXCL8 CYP2E1 IL6 SLC17A5 TNF
2 hepatitis 31.5 F2 GPT KRT18 SLC17A5 TNF
3 fatty liver disease, nonalcoholic 1 30.5 GPT KRT18 SLC17A5
4 hepatitis a 30.5 ALB F2 GPT IL10 TNF
5 infantile liver failure syndrome 1 30.4 ALB F2 GPT SLC17A5
6 hepatic coma 30.3 ALB F2 GPT
7 fournier gangrene 30.1 ALB F2
8 cryptogenic cirrhosis 30.0 F2 KRT18
9 hepatitis b 29.9 ALB F2 GPT SLC17A5 TNF
10 alcoholic liver cirrhosis 29.9 ALB CXCL8 CYP2E1 F2 SLC17A5
11 hepatitis e 29.8 ALB F2 GPT TNF
12 acute liver failure 29.8 ALB F2 GPT SLC17A5
13 portal hypertension 29.8 ALB F2 GPT TNF
14 nonalcoholic steatohepatitis 29.7 CYP2E1 F2 GPT KRT18 SLC17A5 TNF
15 acute pancreatitis 29.6 CXCL8 IL10 IL6
16 hepatic encephalopathy 29.6 ALB F2 GPT IL6 SLC17A5 TNF
17 bilirubin metabolic disorder 29.6 ADAMTS13 ALB F2 GPT SLC17A5
18 protein-energy malnutrition 29.6 ALB GPT IL6 TNF
19 liver disease 29.3 ALB CYP2E1 F2 GPT IL6 KRT18
20 viral hepatitis 29.2 ALB F2 GPT KRT18 SLC17A5 TNF
21 liver cirrhosis 29.2 ALB CYP2E1 F2 GPT KRT18 SLC17A5
22 pneumonia 29.0 CCL2 CXCL8 IL10 IL6 TNF
23 diabetes mellitus, noninsulin-dependent 28.5 ALB CCL2 GPT IL6 SLC17A5 TNF
24 peritonitis 27.5 ALB CCL2 CXCL8 F2 ICAM1 IL10
25 marburg hemorrhagic fever 10.5 F2 TNF
26 exudative glomerulonephritis 10.5 CXCL8 TNF
27 retinitis pigmentosa 55 10.5 IL6 TNF
28 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 IL6 TNF
29 critical limb ischemia 10.5 IL6 TNF
30 juvenile ankylosing spondylitis 10.5 IL6 TNF
31 glossitis 10.5 IL6 TNF
32 laryngitis 10.5 IL6 TNF
33 null-cell leukemia 10.5 IL6 TNF
34 autoimmune myocarditis 10.5 IL6 TNF
35 leukomalacia 10.5 IL6 TNF
36 adult dermatomyositis 10.5 GPT TNF
37 recurrent corneal erosion 10.5 CXCL8 IL6
38 bagassosis 10.5 CXCL8 IL6
39 scorpion envenomation 10.5 IL6 TNF
40 cardiogenic shock 10.5 IL6 TNF
41 papillary conjunctivitis 10.5 CXCL8 IL6
42 burns 10.5 ALB TNF
43 sudden sensorineural hearing loss 10.5 F2 IL6
44 antipyrine metabolism 10.5 ALB F2
45 epstein-barr virus hepatitis 10.5 ALB F2
46 abdominal tuberculosis 10.5 ALB F2
47 hepatoportal sclerosis 10.5 F2 GPT
48 uremic pruritus 10.5 IL6 SLC17A5
49 pyuria 10.5 ALB CXCL8
50 non-a-e hepatitis 10.5 ALB F2

Comorbidity relations with Alcoholic Hepatitis via Phenotypic Disease Network (PDN): (show all 12)


Active Peptic Ulcer Disease Acute Cystitis
Acute Pancreatitis Alcohol Abuse
Alcoholic Gastritis Alcoholic Liver Cirrhosis
Alcoholic Neuropathy Deficiency Anemia
Fatty Liver Disease Hepatic Encephalopathy
Portal Hypertension Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Alcoholic Hepatitis:



Diseases related to Alcoholic Hepatitis

Symptoms & Phenotypes for Alcoholic Hepatitis

MGI Mouse Phenotypes related to Alcoholic Hepatitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.85 ADAMTS13 ALB CYP2E1 F2 ICAM1 IL10
2 liver/biliary system MP:0005370 9.5 ALB CYP2E1 IL10 IL6 KRT18 LBP
3 neoplasm MP:0002006 9.1 ALB CYP2E1 ICAM1 IL10 IL6 TNF

Drugs & Therapeutics for Alcoholic Hepatitis

Drugs for Alcoholic Hepatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 134)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pentoxifylline Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 6493-05-6 4740
2
Ethanol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 64-17-5 702
3
Prednisone Approved, Vet_approved Phase 4,Phase 2,Not Applicable 53-03-2 5865
4
Sargramostim Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 123774-72-1, 83869-56-1
5
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 135968-09-1
6
Acetylcysteine Approved, Investigational Phase 4,Phase 3 616-91-1 12035
7
Caspofungin Approved Phase 4 162808-62-0, 179463-17-3 2826718 468682
8
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
9
Metformin Approved Phase 4 657-24-9 14219 4091
10
Methionine Approved, Nutraceutical Phase 4,Phase 2 63-68-3 6137
11
Choline Approved, Nutraceutical Phase 4 62-49-7 305
12
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 2 65-23-6 1054
13
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 59-30-3 6037
14
Vitamin C Approved, Nutraceutical Phase 4,Phase 2 50-81-7 54670067 5785
15 Polyene phosphatidylcholine Phase 4
16 Antimetabolites Phase 4
17 Hypolipidemic Agents Phase 4
18 Lecithin Phase 4
19 Nootropic Agents Phase 4
20 Lipid Regulating Agents Phase 4
21 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
22 Acidophilus Phase 4,Not Applicable
23 Liver Extracts Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
24 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
25 Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
26 glucocorticoids Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
27 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
28 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
29 Phosphodiesterase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
30 Radiation-Protective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
31 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
32 Free Radical Scavengers Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
33 Hormones Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
34 Antioxidants Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
35 Vasodilator Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
36 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
37 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
38 Anti-Infective Agents, Local Phase 4,Not Applicable
39 Central Nervous System Depressants Phase 4,Not Applicable
40 Immunologic Factors Phase 4,Phase 3,Phase 2,Not Applicable
41 Adjuvants, Immunologic Phase 4,Phase 3,Phase 2,Not Applicable
42 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
43 Antidotes Phase 4,Phase 3
44 Antiviral Agents Phase 4,Phase 3
45 N-monoacetylcystine Phase 4,Phase 3
46 Expectorants Phase 4,Phase 3
47 cysteine Phase 4,Phase 3
48 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Not Applicable
49 Respiratory System Agents Phase 4,Phase 3
50 Folate Phase 4,Phase 2

Interventional clinical trials:

(show top 50) (show all 91)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of S-adenosyl-l-methionine in Treatment of Alcoholic Hepatitis With Cholestasis Unknown status NCT02024295 Phase 4 Ademethionine;Polyene Phosphatidyl choline;Ademethionine
2 Effect of Probiotics on Gut-Liver Axis of Alcoholic Hepatitis Unknown status NCT02335632 Phase 4 Probiotics (Lacidofil®);Placebo
3 Metadoxine as a Therapy for Severe Alcoholic Hepatitis Completed NCT02161653 Phase 4 Prednisone plus Metadoxine;Pentoxifylline plus Metadoxine
4 Pharmacokinetics of Caspofungin After One Dose in Patients With Liver Failure Completed NCT01968395 Phase 4 Caspofungin 70 mg
5 The Effect of High Dose Vitamin C on the Liver Function in Chronic Hepatitis Patients Completed NCT01413360 Phase 4 High dose vitamin C
6 Effect of Probiotics on Gut-Liver Axis of Alcoholic Liver Disease Completed NCT01501162 Phase 4 hepatitis, alcohol, probiotics;alcohol, hepatitis, Placebo
7 GCSF in Alcoholic Hepatitis Recruiting NCT03703674 Phase 4 GCSF
8 G-CSF Plus NAC In Severe Alcoholic Hepatitis Recruiting NCT02971306 Phase 4 standard medical therapy;G-CSF;n-Acetylcysteine
9 Effect of Metadoxine on Oxidative Stress in Non-alcoholic Hepatic Steatosis Recruiting NCT02051842 Phase 4 Metadoxine
10 Rifaximin Use in Severe Alcoholic Hepatitis Unknown status NCT02485106 Phase 3 Rifaximin;Corticosteroid or pentoxifylline
11 N-ACetylcysteine to Reduce Infection and Mortality for Alcoholic Hepatitis Unknown status NCT03069300 Phase 3 N-acetyl cysteine (NAC)
12 Short-term Survival in Patients With Severe Alcoholic Hepatitis Treated With Steroid Versus Pentoxifylline Unknown status NCT01455337 Phase 3 pentoxifylline;Prednisolone
13 Probiotics for Portal Hypertension Unknown status NCT01134692 Phase 3 Propranolol, Norfloxacin, VSL#3
14 N-Acetylcysteine in Severe Acute Alcoholic Hepatitis Completed NCT00962442 Phase 3 N-Acetylcysteine;placebo
15 Treatment of Severe Alcoholic Hepatitis With Corticoids Plus N Acetyl Cysteine Versus Corticoids Alone Completed NCT00863785 Phase 3 Corticoids plus N Acetyl Cysteine
16 Efficacy Study of Anakinra, Pentoxifylline, and Zinc Compared to Methylprednisolone in Severe Acute Alcoholic Hepatitis Completed NCT01809132 Phase 2, Phase 3 Anakinra;Pentoxifylline;Zinc Sulfate;Methylprednisolone
17 Double-blind Randomized Controlled Trial in Severe Alcoholic Hepatitis Completed NCT01214226 Phase 3 Pentoxifylline;placebo
18 Assess Safety and Efficacy of ELAD (Extracorporeal Liver Assist System) in Subjects With Alcohol-Induced Liver Failure Completed NCT01471028 Phase 3
19 Trial for Hepatocellular Carcinoma Adjuvant Treatment by Lipiocis Completed NCT00116454 Phase 3 131 I-lipiodol
20 Efficacy and Safety of the Extracorporeal Liver Assist Device (ELAD) in Acute on Chronic Hepatitis Completed NCT00973817 Phase 2, Phase 3
21 Efficacy of Granulocyte Colony-stimulating Factor and Erythropoetin for Patients With Acute-on-chronic Liver Failure Completed NCT01383460 Phase 3 Granulocyte Colony-stimulating Factor (G-CSF) and Erythropoetin (EPO);Placebo
22 Granulocyte Colony Stimulating Factor And Growth Hormone In Cirrhosis Of Liver: An Open Label Study Completed NCT02451033 Phase 2, Phase 3 standard medical therapy;G-CSF;Growth Hormone
23 A Placebo-Controlled, Double-Blind Study to Confirm the Reversal of Hepatorenal Syndrome Type 1 With Terlipressin Completed NCT01143246 Phase 3 Terlipressin;Placebo
24 Efficacy and Safety of G-CSF in Patients With Severe Alcoholic Hepatitis With Null or Partial Response to Steroid Recruiting NCT02442180 Phase 3 G-CSF (Filgrastim injection);steroid;placebo
25 Comparison of Bovine Colostrum Versus Placebo in Treatment of Severe Alcoholic Hepatitis: A Randomized Double Blind Controlled Trial Recruiting NCT02473341 Phase 3 Bovine Colostrum;Placebo
26 Efficacy of Antibiotic Therapy in Severe Alcoholic Hepatitis Treated With Prednisolone Recruiting NCT02281929 Phase 3 Amoxicillin;Placebo;Prednisolone
27 GCSF Therapy in Decompensated Cirrhosis - A Double Blinded RCT Recruiting NCT03911037 Phase 2, Phase 3 G-CSF;Placebo
28 To Assess Safety/Efficacy of ELAD in Subjects w/ Severe Acute Alcoholic Hepatitis (sAAH) and Lille Score Failure Terminated NCT01829347 Phase 3
29 Randomized, Open-Label, Multicenter, Controlled, Pivotal Study to Assess Safety and Efficacy of ELAD in Subjects w/ AILD Terminated NCT02612428 Phase 3
30 Registry Protocol for Tracking Trial Subjects After VTI-206 Study Completion Withdrawn NCT01452295 Phase 2, Phase 3 ELAD (Extracorporeal Liver Assist System)
31 Effects of Rifaximin in Patients With Acute Alcoholic Hepatitis Unknown status NCT02116556 Phase 2 Prednisone;Rifaximin
32 A Safety and Efficacy Study of Mycophenolate Mofetil and Rilonacept in Patients With Alcoholic Hepatitis Completed NCT01903798 Phase 2 Mycophenolate mofetil;Prednisolone;Rilonacept
33 Use of F-652 in Patients With Alcoholic Hepatitis Completed NCT02655510 Phase 1, Phase 2 F-652
34 Efficacy of Combination Therapy of Glucocorticoids and Bovine Colostrum in Treatment of Severe Alcoholic Hepatitis. Completed NCT02265328 Phase 2
35 Trial of Obeticholic Acid in Patients With Moderately Severe Alcoholic Hepatitis (AH) Completed NCT02039219 Phase 2 Placebo;10 mg Obeticholic Acid (OCA)
36 Selonsertib in Combination With Prednisolone Versus Prednisolone Alone in Participants With Severe Alcoholic Hepatitis (AH) Completed NCT02854631 Phase 2 Selonsertib;Prednisolone;Placebo
37 Efficacy and Safety of MG in the Patients With Alcoholic Fatty Liver Disease and Alcoholic Hepatitis Completed NCT02019056 Phase 2 Placebo /bid P.O;MG-1;MG-2 : MG1000mg, Placebo /bid P.O;metadoxine
38 Safety and Efficacy of IMM 124-E for Patients With Severe Alcoholic Hepatitis Completed NCT01968382 Phase 2 IMM 124-E (Hyperimmune Bovine Colostrum);Placebo (High protein milk powder)
39 Randomized, Controlled Trial of S-adenosylmethionine in Alcoholic Liver Disease Completed NCT00851981 Phase 2
40 Treating Nonalcoholic Steatohepatitis With Pioglitazone Completed NCT00062764 Phase 2 Actos (Pioglitazone)
41 IL-1 Signal Inhibition in Alcoholic Hepatitis Recruiting NCT03775109 Phase 2 Canakinumab 150mg/ml solution for injection;Placebo
42 A Research Study to Assess the Safety, Pharmacokinetics and Pharmacodynamics of DUR-928 in Patients With Alcoholic Hepatitis Recruiting NCT03432260 Phase 2 DUR-928
43 Pegfilgrastim in Patients With Alcoholic Hepatitis Recruiting NCT02776059 Phase 2 Standard of care + pegfiltrastim;Standard of care
44 Vitamin C Infusion for TReatment in Sepsis and Alcoholic Hepatitis Recruiting NCT03829683 Phase 2 Vitamin C;Dextrose 5% in water
45 DUR-928 in Patients With Alcoholic Hepatitis Not yet recruiting NCT03917407 Phase 2 DUR-928 (Moderate AH);DUR-928 (Severe AH)
46 Efficacy and Safety of Orally Administered DS102 in Patients With Acute Alcoholic Hepatitis Not yet recruiting NCT03452540 Phase 2 DS102
47 Study of IDN-6556 in Patients With Severe Alcoholic Hepatitis and Contraindications to Steroid Therapy Terminated NCT01912404 Phase 2 IDN-6556;Placebo
48 Pharmacokinetic and Pharmacodynamic Study of IDN-6556 in ACLF Terminated NCT01937130 Phase 2 IDN-6556
49 Treatment of Alcohol-Related Hepatitis With Arginine Withdrawn NCT00200746 Phase 2 Arginine
50 Fecal Microbial Transplant for Alcohol Misuse in Cirrhosis Recruiting NCT03416751 Phase 1

Search NIH Clinical Center for Alcoholic Hepatitis

Genetic Tests for Alcoholic Hepatitis

Anatomical Context for Alcoholic Hepatitis

MalaCards organs/tissues related to Alcoholic Hepatitis:

42
Liver, Brain, Neutrophil, Monocytes, T Cells, Eye, Prostate

Publications for Alcoholic Hepatitis

Articles related to Alcoholic Hepatitis:

(show top 50) (show all 924)
# Title Authors Year
1
Advances in the treatment of severe alcoholic hepatitis. ( 29781336 )
2019
2
The Role of Liver Transplantation in Alcoholic Hepatitis. ( 29879862 )
2019
3
Urinary acrolein metabolite levels in severe acute alcoholic hepatitis patients. ( 30234998 )
2019
4
Early Liver Transplantation for Alcoholic Hepatitis. ( 30315772 )
2019
5
Outcomes After Early Liver Transplantation for Patients With Severe Alcoholic Hepatitis: Additional Evidence From a Meta-analysis. ( 30315775 )
2019
6
Incidence, inhospital mortality, and readmission among patients with alcoholic hepatitis in Korea: A nationwide study. ( 30345539 )
2019
7
Acute Alcoholic Hepatitis. ( 30454835 )
2019
8
Only in the darkness can you see the stars: Severe alcoholic hepatitis and higher grades of acute-on-chronic liver failure. ( 30470480 )
2019
9
Treatment retention in a specialized alcohol programme after an episode of alcoholic hepatitis: Impact on alcohol relapse. ( 30654998 )
2019
10
Current trials and novel therapeutic targets for alcoholic hepatitis. ( 30658731 )
2019
11
Endpoints and patient stratification in clinical trials for alcoholic hepatitis. ( 30658732 )
2019
12
Liver transplantation for alcoholic hepatitis. ( 30658734 )
2019
13
Efficacy of g-csf in the management of steroid-nonresponsive severe alcoholic hepatitis: a double-blind randomized controlled trial. ( 30664267 )
2019
14
Non-uremic calciphylaxis associated with alcoholic hepatitis: A case report. ( 30705725 )
2019
15
Porphyromonas gingivalis as a Possible Risk Factor in the Development/Severity of Acute Alcoholic Hepatitis. ( 30766965 )
2019
16
The future of therapy for alcoholic hepatitis - Beyond corticosteroids. ( 30791978 )
2019
17
Liver Transplantation for Alcoholic Hepatitis is Likely Underestimated in the National Transplant Database. ( 30882995 )
2019
18
Biomarkers of macrophage activation and immune danger signals predict clinical outcomes in alcoholic hepatitis. ( 30891779 )
2019
19
A Lille model for predicting the response of severe alcoholic hepatitis to corticosteroid treatment in Japanese patients. ( 30901152 )
2019
20
Incidence and Risk Factors Associated With 30-Day Readmission for Alcoholic Hepatitis. ( 30950924 )
2019
21
4-Methylcoumarin-[5,6-g]-hesperetin attenuates inflammatory responses in alcoholic hepatitis through PPAR-γ activation. ( 30951781 )
2019
22
Glucocorticosteroids for people with alcoholic hepatitis. ( 30964545 )
2019
23
Recent updates on alcoholic hepatitis. ( 31010745 )
2019
24
Relative Adrenal Insufficiency in Patients with Alcoholic Hepatitis. ( 31024204 )
2019
25
Alcohol Rehabilitation Within 30 Days of Hospital Discharge is Associated With Reduced Readmission, Relapse, and Death in Patients with Alcoholic Hepatitis. ( 31042580 )
2019
26
Letter: high ferritin to haemoglobin ratio is related to early mortality in patients with alcoholic hepatitis - author's reply. ( 31074897 )
2019
27
Letter: high ferritin to haemoglobin ratio is related to early mortality in patients with alcoholic hepatitis. ( 31074902 )
2019
28
Histological activity score on baseline liver biopsy can predict non-response to steroids in patients with severe alcoholic hepatitis. ( 29516163 )
2018
29
The prognostic value of acute-on-chronic liver failure during the course of severe alcoholic hepatitis. ( 29524528 )
2018
30
The long-term prognosis of alcoholic hepatitis is poor and independent of disease severity for patients surviving an acute episode. ( 29524529 )
2018
31
Reply to: "The long-term prognosis of alcoholic hepatitis is poor and independent of disease severity for patients surviving an acute episode". ( 29524533 )
2018
32
Characterization of intestinal microbiota in alcoholic patients with and without alcoholic hepatitis or chronic alcoholic pancreatitis. ( 29555983 )
2018
33
Alcoholic Hepatitis: Lost in Translation. ( 29577035 )
2018
34
Correction: Survival from alcoholic hepatitis has not improved over time. ( 29634763 )
2018
35
Dysregulation of serum bile acids and FGF19 in alcoholic hepatitis. ( 29654817 )
2018
36
Outcomes of Early Liver Transplantation for Patients With Severe Alcoholic Hepatitis. ( 29655837 )
2018
37
Noncholesterol Sterols as Surrogate Markers in Patients with Severe Alcoholic Hepatitis. ( 29663389 )
2018
38
Liver transplantation for alcoholic hepatitis: Being consistent about where to set the bar. ( 29694706 )
2018
39
Measuring Intrahepatic Vascular Changes Using Contrast-Enhanced Ultrasonography to Predict the Prognosis of Alcoholic Hepatitis Combined with Cirrhosis: A Prospective Pilot Study. ( 29699059 )
2018
40
In vivo imaging of hepatic neutrophil migration in severe alcoholic hepatitis with 111In-radiolabelled leucocytes. ( 29700216 )
2018
41
Predictors of 90-day mortality in patients with severe alcoholic hepatitis: Experience with 183 patients at a tertiary care center from India. ( 29704174 )
2018
42
Alcoholic steatohepatitis (ASH) and alcoholic hepatitis (AH): cascade of events, clinical aspects, and pharmacotherapy options. ( 29708448 )
2018
43
A return to harmful alcohol consumption impacts on portal hemodynamic changes following alcoholic hepatitis. ( 29727387 )
2018
44
Corticosteroids Reduce Risk of Death Within 28 Days for Patients With Severe Alcoholic Hepatitis, Compared With Pentoxifylline or Placebo-a Meta-analysis of Individual Data From Controlled Trials. ( 29738698 )
2018
45
Grand Rounds: Alcoholic Hepatitis. ( 29753761 )
2018
46
Exploring new treatment paradigms for alcoholic hepatitis by extrapolating from NASH and cholestasis. ( 29792896 )
2018
47
Knockout of microRNA-21 attenuates alcoholic hepatitis through the VHL/NF-κB signaling pathway in hepatic stellate cells. ( 29848019 )
2018
48
Alcohol, Diet and Drug Use Preceding Alcoholic Hepatitis. ( 29852499 )
2018
49
Can we reliably predict response to corticosteroid treatment in severe alcoholic hepatitis? ( 29881814 )
2018
50
Baseline urine metabolic phenotype in patients with severe alcoholic hepatitis and its association with outcome. ( 29881815 )
2018

Variations for Alcoholic Hepatitis

Expression for Alcoholic Hepatitis

LifeMap Discovery
Genes differentially expressed in tissues of Alcoholic Hepatitis patients vs. healthy controls: 35 (show top 50) (show all 111)
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) Liver + 8.79 0.000
2 KRT23 keratin 23, type I Liver + 7.04 0.000
3 FOS FBJ murine osteosarcoma viral oncogene homolog Liver - 6.75 0.000
4 CCL20 chemokine (C-C motif) ligand 20 Liver + 6.56 0.000
5 KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 Liver - 6.11 0.000
6 SPINK1 serine peptidase inhibitor, Kazal type 1 Liver + 6.07 0.000
7 SPP1 secreted phosphoprotein 1 Liver + 6.04 0.000
8 LCN2 lipocalin 2 Liver + 5.74 0.000
9 CXCL6 chemokine (C-X-C motif) ligand 6 Liver + 5.55 0.000
10 COL1A2 collagen, type I, alpha 2 Liver + 5.33 0.000
11 FOSB FBJ murine osteosarcoma viral oncogene homolog B Liver - 5.08 0.000
12 LOXL4 lysyl oxidase-like 4 Liver + 5.01 0.000
13 PDZK1IP1 PDZK1 interacting protein 1 Liver + 4.95 0.000
14 CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 Liver - 4.91 0.000
15 GOLM1 golgi membrane protein 1 Liver + 4.87 0.000
16 NR4A2 nuclear receptor subfamily 4, group A, member 2 Liver - 4.85 0.000
17 MMP7 matrix metallopeptidase 7 Liver + 4.73 0.000
18 EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 Liver + 4.63 0.000
19 CD24 CD24 molecule Liver + 4.57 0.000
20 GNMT glycine N-methyltransferase Liver - 4.50 0.000
21 PCOLCE2 procollagen C-endopeptidase enhancer 2 Liver - 4.48 0.000
22 CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 Liver - 4.45 0.000
23 TACSTD2 tumor-associated calcium signal transducer 2 Liver + 4.41 0.000
24 DCDC2 doublecortin domain containing 2 Liver + 4.28 0.000
25 EPCAM epithelial cell adhesion molecule Liver + 4.26 0.000
26 NQO1 NAD(P)H dehydrogenase, quinone 1 Liver + 4.10 0.000
27 MT1M metallothionein 1M Liver - 4.07 0.000
28 SOX9 SRY (sex determining region Y)-box 9 Liver + 3.99 0.000
29 THBS2 thrombospondin 2 Liver + 3.98 0.000
30 KRT7 keratin 7, type II Liver + 3.96 0.000
31 BICC1 BicC family RNA binding protein 1 Liver + 3.96 0.000
32 FABP4 fatty acid binding protein 4, adipocyte Liver + 3.94 0.000
33 IL32 interleukin 32 Liver + 3.94 0.000
34 PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A Liver - 3.91 0.000
35 RRM2 ribonucleotide reductase M2 Liver + 3.90 0.000
36 CXCL8 chemokine (C-X-C motif) ligand 8 Liver + 3.90 0.000
37 VCAN versican Liver + 3.90 0.000
38 COL1A1 collagen, type I, alpha 1 Liver + 3.89 0.000
39 DUSP1 dual specificity phosphatase 1 Liver - 3.89 0.000
40 LGSN lengsin, lens protein with glutamine synthetase domain Liver - 3.78 0.000
41 COL5A1 collagen, type V, alpha 1 Liver + 3.77 0.000
42 SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 Liver - 3.77 0.000
43 RGS4 regulator of G-protein signaling 4 Liver + 3.76 0.000
44 STMN2 stathmin 2 Liver + 3.72 0.000
45 SOX4 SRY (sex determining region Y)-box 4 Liver + 3.71 0.000
46 CLEC4M C-type lectin domain family 4, member M Liver - 3.69 0.000
47 ANXA2 annexin A2 Liver + 3.67 0.000
48 ANXA2P2 annexin A2 pseudogene 2 Liver + 3.66 0.000
49 CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family) Liver - 3.65 0.000
50 GPR88 G protein-coupled receptor 88 Liver - 3.64 0.000
Search GEO for disease gene expression data for Alcoholic Hepatitis.

Pathways for Alcoholic Hepatitis

Pathways related to Alcoholic Hepatitis according to GeneCards Suite gene sharing:

(show all 49)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.5 CCL2 CXCL8 F2 ICAM1 IL10 IL22
2
Show member pathways
13.27 CCL2 CXCL8 ICAM1 IL10 IL22 IL6
3
Show member pathways
13.24 CCL2 CXCL8 IL10 IL22 IL6 TNF
4
Show member pathways
13.06 CCL2 CXCL8 IL10 IL6 LBP TNF
5
Show member pathways
12.9 CCL2 CXCL8 ICAM1 IL6 TNF
6
Show member pathways
12.84 CXCL8 ICAM1 IL10 IL22 IL6 TNF
7
Show member pathways
12.57 CCL2 F2 IL10 IL6 TNF
8
Show member pathways
12.54 IL10 IL22 IL6 TNF
9
Show member pathways
12.31 CCL2 CXCL8 IL6 TNF
10
Show member pathways
12.28 CXCL8 IL6 LBP TNF
11 12.22 IL10 IL6 LBP TNF
12
Show member pathways
12.21 CXCL8 IL10 IL6 TNF
13
Show member pathways
12.18 CXCL8 IL6 LBP TNF
14
Show member pathways
12.18 ALB CCL2 F2 ICAM1 IL6 TNF
15 12.17 CXCL8 IL10 IL6 TNF
16
Show member pathways
12.04 IL10 IL22 IL6 TNF
17
Show member pathways
11.98 F2 IL6 TNF
18
Show member pathways
11.97 CCL2 CXCL8 ICAM1 IL10 IL22 IL6
19 11.95 CCL2 ICAM1 IL6 TNF
20 11.94 IL10 IL6 TNF
21 11.93 CCL2 CXCL8 ICAM1 IL6 TNF
22 11.88 CXCL8 ICAM1 LBP TNF
23 11.87 CXCL8 IL10 IL6 TNF
24
Show member pathways
11.85 CXCL8 ICAM1 IL6 LBP
25 11.8 CXCL8 IL6 LBP
26 11.8 CCL2 CXCL8 ICAM1 IL6 TNF
27 11.78 CXCL8 ICAM1 IL6
28 11.76 IL10 IL22 TNF
29 11.72 IL10 IL6 TNF
30 11.72 CXCL8 IL10 IL6 TNF
31 11.68 CCL2 IL10 IL6 TNF
32 11.68 CCL2 CXCL8 ICAM1 IL6 TNF
33 11.61 CCL2 CXCL8 IL6 TNF
34
Show member pathways
11.6 CXCL8 ICAM1 IL6 TNF
35 11.59 CXCL8 IL6 TNF
36 11.52 ICAM1 IL6 TNF
37 11.37 IL10 IL6 TNF
38 11.35 CCL2 CXCL8 IL6
39 11.32 CCL2 CXCL8 ICAM1 IL10 IL6 TNF
40 11.31 IL22 IL6 TNF
41 11.3 ICAM1 IL10 IL6 TNF
42 11.26 IL10 IL6 TNF
43 11.22 CCL2 CXCL8 ICAM1 IL10 IL6 LBP
44 11.17 CCL2 F2 ICAM1
45 11.12 CCL2 CXCL8 ICAM1 IL10 IL6 TNF
46 11.02 CXCL8 IL6 TNF
47 10.99 CCL2 CXCL8 IL10 IL22 IL6 TNF
48 10.96 CCL2 CXCL8 IL10 IL22 IL6 TNF
49 10.93 CCL2 ICAM1 TNF

GO Terms for Alcoholic Hepatitis

Cellular components related to Alcoholic Hepatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 ADAMTS13 ALB CCL2 CXCL8 F2 IL10
2 endoplasmic reticulum lumen GO:0005788 9.46 ADAMTS13 ALB F2 IL6
3 extracellular space GO:0005615 9.4 ADAMTS13 ALB CCL2 CXCL8 F2 GPT

Biological processes related to Alcoholic Hepatitis according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.97 CCL2 CXCL8 IL10 IL6 TNF
2 positive regulation of DNA-binding transcription factor activity GO:0051091 9.81 IL10 IL6 TNF
3 response to bacterium GO:0009617 9.8 CCL2 CYP2E1 SLC17A5
4 platelet activation GO:0030168 9.8 ADAMTS13 F2 IL6
5 inflammatory response GO:0006954 9.8 CCL2 CXCL8 IL10 IL22 IL6 TNF
6 cellular response to interferon-gamma GO:0071346 9.79 ADAMTS13 CCL2 ICAM1
7 defense response to Gram-positive bacterium GO:0050830 9.79 IL6 LBP TNF
8 cellular response to interleukin-1 GO:0071347 9.77 CCL2 CXCL8 ICAM1
9 cellular response to tumor necrosis factor GO:0071356 9.76 ADAMTS13 CCL2 CXCL8 ICAM1
10 positive regulation of interleukin-6 production GO:0032755 9.7 IL6 LBP TNF
11 regulation of signaling receptor activity GO:0010469 9.7 CCL2 CXCL8 F2 IL10 IL22 IL6
12 humoral immune response GO:0006959 9.69 CCL2 IL6 TNF
13 response to glucocorticoid GO:0051384 9.67 IL10 IL22 IL6 TNF
14 embryonic digestive tract development GO:0048566 9.65 CXCL8 TNF
15 positive regulation of glial cell proliferation GO:0060252 9.65 IL6 TNF
16 lipopolysaccharide-mediated signaling pathway GO:0031663 9.65 CCL2 LBP TNF
17 positive regulation of macrophage activation GO:0043032 9.64 IL10 LBP
18 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.63 IL10 TNF
19 PERK-mediated unfolded protein response GO:0036499 9.61 CCL2 CXCL8
20 positive regulation of chemokine production GO:0032722 9.61 IL6 LBP TNF
21 response to molecule of bacterial origin GO:0002237 9.6 CXCL8 IL10
22 negative regulation of lipid storage GO:0010888 9.58 IL6 TNF
23 endothelial cell apoptotic process GO:0072577 9.58 IL10 TNF
24 negative regulation of growth of symbiont in host GO:0044130 9.58 IL10 LBP TNF
25 negative regulation of cytokine secretion involved in immune response GO:0002740 9.56 IL10 TNF
26 acute-phase response GO:0006953 9.56 F2 IL22 IL6 LBP
27 cytokine-mediated signaling pathway GO:0019221 9.56 CCL2 CXCL8 ICAM1 IL10 IL22 IL6
28 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.55 ICAM1 TNF
29 positive regulation of neuroinflammatory response GO:0150078 9.54 IL6 TNF
30 receptor biosynthetic process GO:0032800 9.49 IL10 TNF
31 cellular response to lipopolysaccharide GO:0071222 9.23 ADAMTS13 CCL2 CXCL8 ICAM1 IL10 IL6

Molecular functions related to Alcoholic Hepatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 CCL2 CXCL8 IL10 IL22 IL6 TNF

Sources for Alcoholic Hepatitis

3 CDC
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17 EFO
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70 SNOMED-CT via HPO
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75 UMLS via Orphanet
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