MCID: ALC006
MIFTS: 63

Alcoholic Hepatitis

Categories: Endocrine diseases, Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Alcoholic Hepatitis

MalaCards integrated aliases for Alcoholic Hepatitis:

Name: Alcoholic Hepatitis 38 12 76 15
Acute Alcoholic Liver Disease 12 73
Acute Alcoholic Hepatitis 12 55
Hepatitis, Alcoholic 73
Hepatitis Alcoholic 55

Classifications:



External Ids:

Disease Ontology 12 DOID:12351
ICD9CM 35 571.1
NCIt 50 C34352
SNOMED-CT 68 9953008
ICD10 33 K70.1

Summaries for Alcoholic Hepatitis

MalaCards based summary : Alcoholic Hepatitis, also known as acute alcoholic liver disease, is related to fatty liver disease and hepatitis. An important gene associated with Alcoholic Hepatitis is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways are TGF-Beta Pathway and Cytokine Signaling in Immune system. The drugs Metformin and Ethanol have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and neutrophil, and related phenotypes are homeostasis/metabolism and liver/biliary system

Wikipedia : 76 Alcoholic hepatitis is hepatitis (inflammation of the liver) due to excessive intake of alcohol. It is... more...

Related Diseases for Alcoholic Hepatitis

Diseases related to Alcoholic Hepatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 351)
# Related Disease Score Top Affiliating Genes
1 fatty liver disease 32.0 CXCL8 CYP2E1 IL6 SLC17A5 TNF
2 hepatitis 31.4 F2 GPT KRT18 SLC17A5 TNF
3 hepatitis a 30.5 ALB F2 GPT IL10 TNF
4 infantile liver failure syndrome 1 30.2 ALB F2 GPT SLC17A5
5 fatty liver disease, nonalcoholic 1 30.2 GPT KRT18 SLC17A5
6 hepatitis b 29.8 ALB F2 GPT SLC17A5 TNF
7 hepatic coma 29.8 ALB F2 GPT
8 cryptogenic cirrhosis 29.8 F2 KRT18
9 alcoholic liver cirrhosis 29.7 ALB CXCL8 CYP2E1 F2 SLC17A5
10 hepatitis e 29.7 ALB F2 GPT TNF
11 acute liver failure 29.7 ALB F2 GPT SLC17A5
12 portal hypertension 29.7 ALB F2 GPT TNF
13 nonalcoholic steatohepatitis 29.7 CYP2E1 F2 GPT KRT18 SLC17A5 TNF
14 viral infectious disease 29.7 CXCL8 GPT IL10 IL6 TNF
15 liver disease 29.6 ALB CYP2E1 F2 GPT IL6 KRT18
16 hepatic encephalopathy 29.6 ALB F2 GPT IL6 SLC17A5 TNF
17 acute pancreatitis 29.5 CXCL8 IL10 IL6
18 protein-energy malnutrition 29.4 ALB GPT IL6 TNF
19 liver cirrhosis 29.3 ALB CYP2E1 F2 GPT KRT18 SLC17A5
20 nonalcoholic fatty liver disease 29.3 CYP2E1 IL6 KRT18 TNF
21 pneumonia 29.3 CCL2 CXCL8 IL10 IL6 TNF
22 viral hepatitis 29.3 ALB F2 GPT KRT18 SLC17A5 TNF
23 peritonitis 28.2 ALB CCL2 CXCL8 F2 ICAM1 IL10
24 marburg hemorrhagic fever 10.3 F2 TNF
25 exudative glomerulonephritis 10.3 CXCL8 TNF
26 retinitis pigmentosa 55 10.3 IL6 TNF
27 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 IL6 TNF
28 critical limb ischemia 10.3 IL6 TNF
29 juvenile ankylosing spondylitis 10.3 IL6 TNF
30 glossitis 10.3 IL6 TNF
31 laryngitis 10.3 IL6 TNF
32 null-cell leukemia 10.3 IL6 TNF
33 anca-associated vasculitis 10.3 IL6 TNF
34 antipyrine metabolism 10.3 ALB F2
35 leukomalacia 10.3 IL6 TNF
36 recurrent corneal erosion 10.3 CXCL8 IL6
37 scorpion envenomation 10.3 IL6 TNF
38 bagassosis 10.3 CXCL8 IL6
39 cardiogenic shock 10.3 IL6 TNF
40 epstein-barr virus hepatitis 10.3 ALB F2
41 abdominal tuberculosis 10.3 ALB F2
42 papillary conjunctivitis 10.3 CXCL8 IL6
43 sudden sensorineural hearing loss 10.3 F2 IL6
44 pyuria 10.3 ALB CXCL8
45 fournier gangrene 10.3 ALB F2
46 non-a-e hepatitis 10.3 ALB F2
47 shwartzman phenomenon 10.3 ICAM1 TNF
48 uremic pruritus 10.3 IL6 SLC17A5
49 toxicodendron dermatitis 10.3 CXCL8 ICAM1
50 heterophyiasis 10.3 ALB ICAM1

Comorbidity relations with Alcoholic Hepatitis via Phenotypic Disease Network (PDN): (show all 12)


Active Peptic Ulcer Disease Acute Cystitis
Acute Pancreatitis Alcohol Abuse
Alcoholic Gastritis Alcoholic Liver Cirrhosis
Alcoholic Neuropathy Deficiency Anemia
Fatty Liver Disease Hepatic Encephalopathy
Portal Hypertension Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Alcoholic Hepatitis:



Diseases related to Alcoholic Hepatitis

Symptoms & Phenotypes for Alcoholic Hepatitis

MGI Mouse Phenotypes related to Alcoholic Hepatitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.85 ADAMTS13 ALB CYP2E1 F2 ICAM1 IL10
2 liver/biliary system MP:0005370 9.5 ALB CYP2E1 IL10 IL6 KRT18 LBP
3 neoplasm MP:0002006 9.1 ALB CYP2E1 ICAM1 IL10 IL6 TNF

Drugs & Therapeutics for Alcoholic Hepatitis

Drugs for Alcoholic Hepatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 135)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4 657-24-9 14219 4091
2
Ethanol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 64-17-5 702
3
Prednisone Approved, Vet_approved Phase 4,Phase 2 53-03-2 5865
4
Pentoxifylline Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 6493-05-6 4740
5
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 135968-09-1
6
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
7
Caspofungin Approved Phase 4 179463-17-3, 162808-62-0 468682 2826718
8
Acetylcysteine Approved, Investigational Phase 4,Phase 3 616-91-1 12035
9
Methionine Approved, Nutraceutical Phase 4,Phase 2 63-68-3 6137
10
Choline Approved, Nutraceutical Phase 4 62-49-7 305
11
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 2 65-23-6 1054
12
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 59-30-3 6037
13
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
14 Polyene phosphatidylcholine Phase 4
15 Antimetabolites Phase 4
16 Hypolipidemic Agents Phase 4
17 Lecithin Phase 4
18 Nootropic Agents Phase 4
19 Lipid Regulating Agents Phase 4
20 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
21 Acidophilus Phase 4,Not Applicable
22 Liver Extracts Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
23 Folate Phase 4,Phase 2
24 Vitamin B9 Phase 4,Phase 2
25 Micronutrients Phase 4,Phase 2,Phase 3
26 Vitamin B 6 Phase 4,Phase 2
27 Vitamins Phase 4,Phase 3,Phase 2
28 Trace Elements Phase 4,Phase 2,Phase 3
29 Vitamin B Complex Phase 4,Phase 2
30 Metadoxine Phase 4,Phase 2
31 Antioxidants Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
32 Vasodilator Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
33 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
34 Free Radical Scavengers Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
35 Hormones Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
36 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
37 Phosphodiesterase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
38 Radiation-Protective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
39 glucocorticoids Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
40 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
41 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
42 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
43 Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
44 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
45 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
46 Adjuvants, Immunologic Phase 4,Phase 3,Phase 2,Not Applicable
47 Immunologic Factors Phase 4,Phase 3,Phase 2,Not Applicable
48 Antifungal Agents Phase 4
49 Echinocandins Phase 4
50 Anti-Infective Agents, Local Phase 4,Not Applicable

Interventional clinical trials:

(show top 50) (show all 83)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of S-adenosyl-l-methionine in Treatment of Alcoholic Hepatitis With Cholestasis Unknown status NCT02024295 Phase 4 Ademethionine;Polyene Phosphatidyl choline;Ademethionine
2 Effect of Probiotics on Gut-Liver Axis of Alcoholic Hepatitis Unknown status NCT02335632 Phase 4 Probiotics (Lacidofil®);Placebo
3 Effect of Metadoxine on Oxidative Stress in Non-alcoholic Hepatic Steatosis Unknown status NCT02051842 Phase 4 Metadoxine
4 Metadoxine as a Therapy for Severe Alcoholic Hepatitis Completed NCT02161653 Phase 4 Prednisone plus Metadoxine;Pentoxifylline plus Metadoxine
5 Pharmacokinetics of Caspofungin After One Dose in Patients With Liver Failure Completed NCT01968395 Phase 4 Caspofungin 70 mg
6 The Effect of High Dose Vitamin C on the Liver Function in Chronic Hepatitis Patients Completed NCT01413360 Phase 4 High dose vitamin C
7 Effect of Probiotics on Gut-Liver Axis of Alcoholic Liver Disease Completed NCT01501162 Phase 4 hepatitis, alcohol, probiotics;alcohol, hepatitis, Placebo
8 GCSF in Alcoholic Hepatitis Recruiting NCT03703674 Phase 4 GCSF
9 G-CSF Plus NAC In Severe Alcoholic Hepatitis Recruiting NCT02971306 Phase 4 standard medical therapy;G-CSF;n-Acetylcysteine
10 Rifaximin Use in Severe Alcoholic Hepatitis Unknown status NCT02485106 Phase 3 Rifaximin;Corticosteroid or pentoxifylline
11 Short-term Survival in Patients With Severe Alcoholic Hepatitis Treated With Steroid Versus Pentoxifylline Unknown status NCT01455337 Phase 3 pentoxifylline;Prednisolone
12 Probiotics for Portal Hypertension Unknown status NCT01134692 Phase 3 Propranolol, Norfloxacin, VSL#3
13 N-Acetylcysteine in Severe Acute Alcoholic Hepatitis Completed NCT00962442 Phase 3 N-Acetylcysteine;placebo
14 Treatment of Severe Alcoholic Hepatitis With Corticoids Plus N Acetyl Cysteine Versus Corticoids Alone Completed NCT00863785 Phase 3 Corticoids plus N Acetyl Cysteine
15 Efficacy Study of Anakinra, Pentoxifylline, and Zinc Compared to Methylprednisolone in Severe Acute Alcoholic Hepatitis Completed NCT01809132 Phase 2, Phase 3 Anakinra;Pentoxifylline;Zinc Sulfate;Methylprednisolone
16 Double-blind Randomized Controlled Trial in Severe Alcoholic Hepatitis Completed NCT01214226 Phase 3 Pentoxifylline;placebo
17 Assess Safety and Efficacy of ELAD (Extracorporeal Liver Assist System) in Subjects With Alcohol-Induced Liver Failure Completed NCT01471028 Phase 3
18 Trial for Hepatocellular Carcinoma Adjuvant Treatment by Lipiocis Completed NCT00116454 Phase 3 131 I-lipiodol
19 Efficacy and Safety of the Extracorporeal Liver Assist Device (ELAD) in Acute on Chronic Hepatitis Completed NCT00973817 Phase 2, Phase 3
20 Efficacy of Granulocyte Colony-stimulating Factor and Erythropoetin for Patients With Acute-on-chronic Liver Failure Completed NCT01383460 Phase 3 Granulocyte Colony-stimulating Factor (G-CSF) and Erythropoetin (EPO);Placebo
21 Granulocyte Colony Stimulating Factor And Growth Hormone In Cirrhosis Of Liver: An Open Label Study Completed NCT02451033 Phase 2, Phase 3 standard medical therapy;G-CSF;Growth Hormone
22 A Placebo-Controlled, Double-Blind Study to Confirm the Reversal of Hepatorenal Syndrome Type 1 With Terlipressin Completed NCT01143246 Phase 3 Terlipressin;Placebo
23 Efficacy and Safety of G-CSF in Patients With Severe Alcoholic Hepatitis With Null or Partial Response to Steroid Recruiting NCT02442180 Phase 3 G-CSF (Filgrastim injection);steroid;placebo
24 Comparison of Bovine Colostrum Versus Placebo in Treatment of Severe Alcoholic Hepatitis: A Randomized Double Blind Controlled Trial Recruiting NCT02473341 Phase 3 Bovine Colostrum;Placebo
25 Efficacy of Antibiotic Therapy in Severe Alcoholic Hepatitis Treated With Prednisolone Recruiting NCT02281929 Phase 3 Amoxicillin;Placebo;Prednisolone
26 N-ACetylcysteine to Reduce Infection and Mortality for Alcoholic Hepatitis Recruiting NCT03069300 Phase 3 N-acetyl cysteine (NAC)
27 Study to Assess Safety and Efficacy of ELAD in Subjects With Severe Acute Alcoholic Hepatitis (sAAH) and Lille Score Failure Terminated NCT01829347 Phase 3
28 Randomized, Open-Label, Multicenter, Controlled, Pivotal Study to Assess Safety and Efficacy of ELAD in Subjects w/ AILD Terminated NCT02612428 Phase 3
29 Registry Protocol for Tracking Trial Subjects After VTI-206 Study Completion Withdrawn NCT01452295 Phase 2, Phase 3 ELAD (Extracorporeal Liver Assist System)
30 Effects of Rifaximin in Patients With Acute Alcoholic Hepatitis Unknown status NCT02116556 Phase 2 Prednisone;Rifaximin
31 A Safety and Efficacy Study of Mycophenolate Mofetil and Rilonacept in Patients With Alcoholic Hepatitis Completed NCT01903798 Phase 2 Mycophenolate mofetil;Prednisolone;Rilonacept
32 Use of F-652 in Patients With Alcoholic Hepatitis Completed NCT02655510 Phase 1, Phase 2 F-652
33 Efficacy of Combination Therapy of Glucocorticoids and Bovine Colostrum in Treatment of Severe Alcoholic Hepatitis. Completed NCT02265328 Phase 2
34 Trial of Obeticholic Acid in Patients With Moderately Severe Alcoholic Hepatitis (AH) Completed NCT02039219 Phase 2 Placebo;10 mg Obeticholic Acid (OCA)
35 Selonsertib in Combination With Prednisolone Versus Prednisolone Alone in Participants With Severe Alcoholic Hepatitis (AH) Completed NCT02854631 Phase 2 Selonsertib;Prednisolone;Placebo
36 Efficacy and Safety of MG in the Patients With Alcoholic Fatty Liver Disease and Alcoholic Hepatitis Completed NCT02019056 Phase 2 Placebo /bid P.O;MG-1;MG-2 : MG1000mg, Placebo /bid P.O;metadoxine
37 Randomized, Controlled Trial of S-adenosylmethionine in Alcoholic Liver Disease Completed NCT00851981 Phase 2
38 Treating Nonalcoholic Steatohepatitis With Pioglitazone Completed NCT00062764 Phase 2 Actos (Pioglitazone)
39 IL-1 Signal Inhibition in Alcoholic Hepatitis (ISAIAH) Recruiting NCT03775109 Phase 2 Canakinumab 150mg/ml solution for injection;Placebo
40 A Research Study to Assess the Safety, Pharmacokinetics and Pharmacodynamics of DUR-928 in Patients With Alcoholic Hepatitis Recruiting NCT03432260 Phase 2 DUR-928
41 Pegfilgrastim in Patients With Alcoholic Hepatitis Recruiting NCT02776059 Phase 2 Standard of care + pegfiltrastim;Standard of care
42 Safety and Efficacy of IMM 124-E for Patients With Severe Alcoholic Hepatitis Active, not recruiting NCT01968382 Phase 2 IMM 124-E (Hyperimmune Bovine Colostrum);Placebo (High protein milk powder)
43 Efficacy and Safety of Orally Administered DS102 in Patients With Acute Alcoholic Hepatitis Not yet recruiting NCT03452540 Phase 2 DS102
44 Study of IDN-6556 in Patients With Severe Alcoholic Hepatitis and Contraindications to Steroid Therapy Terminated NCT01912404 Phase 2 IDN-6556;Placebo
45 Pharmacokinetic and Pharmacodynamic Study of IDN-6556 in ACLF Terminated NCT01937130 Phase 2 IDN-6556
46 Treatment of Alcohol-Related Hepatitis With Arginine Withdrawn NCT00200746 Phase 2 Arginine
47 Fecal Microbial Transplant for Alcohol Misuse in Cirrhosis Recruiting NCT03416751 Phase 1
48 Pentoxifylline for Acute Alcoholic Hepatitis (AAH) Terminated NCT00205049 Phase 1 pentoxifylline
49 Pilot Study of Pentoxifylline for Hepatopulmonary Syndrome Terminated NCT00593658 Phase 1 pentoxifylline
50 Granulocyte Colony Stimulating Factor (G-CSF) in Acute Liver Failure and Alcoholic Hepatitis Unknown status NCT01341951 Not Applicable Granulocyte colony stimulating factor

Search NIH Clinical Center for Alcoholic Hepatitis

Genetic Tests for Alcoholic Hepatitis

Anatomical Context for Alcoholic Hepatitis

MalaCards organs/tissues related to Alcoholic Hepatitis:

41
Liver, Brain, Neutrophil, T Cells, Monocytes, Testes, Eye

Publications for Alcoholic Hepatitis

Articles related to Alcoholic Hepatitis:

(show top 50) (show all 891)
# Title Authors Year
1
Acute Alcoholic Hepatitis. ( 30454835 )
2019
2
Knockout of microRNA-21 attenuates alcoholic hepatitis through VHL/NF-I_B signaling pathway in hepatic stellate cells. ( 29848019 )
2018
3
Can we reliably predict response to corticosteroid treatment in severe alcoholic hepatitis? ( 29881814 )
2018
4
Role of liver transplantation in severe alcoholic hepatitis. ( 29316778 )
2018
5
A new marker for severity of alcoholic hepatitis. ( 29427735 )
2018
6
Modification Patterns of Urinary Albumin Correlates With Serum Albumin and Outcome in Severe Alcoholic Hepatitis. ( 29369844 )
2018
7
Liver Transplantation for Severe Alcoholic Hepatitis, Updated Lessons from the World's Largest Series. ( 29409981 )
2018
8
People who survive an episode of severe alcoholic hepatitis should be advised to maintain total abstinence from alcohol. ( 29394458 )
2018
9
Survival from alcoholic hepatitis has not improved over time. ( 29444123 )
2018
10
Grand Rounds: Alcoholic Hepatitis. ( 29753761 )
2018
11
Alcoholic steatohepatitis (ASH) and alcoholic hepatitis (AH): cascade of events, clinical aspects, and pharmacotherapy options. ( 29708448 )
2018
12
Early liver transplantation for severe alcoholic hepatitis: moving from controversy to consensus. ( 29389821 )
2018
13
Malnutrition is a key prognostic factor related to high mortality-rate in patients with severe alcoholic hepatitis. ( 29974779 )
2018
14
Interaction between the patatin-like phospholipase domain-containing protein 3 genotype and coffee drinking and the risk for acute alcoholic hepatitis. ( 29404510 )
2018
15
<i>In vivo</i> imaging of hepatic neutrophil migration in severe alcoholic hepatitis with <sup>111</sup>In-radiolabelled leucocytes. ( 29700216 )
2018
16
More than meets the eye: Severe alcoholic hepatitis can present as acute-on-chronic liver failure. ( 29935965 )
2018
17
Extracorporeal Cellular Therapy (ELAD) in Severe Alcoholic Hepatitis- A Multinational, Prospective, Controlled, Randomized Trial. ( 29385313 )
2018
18
Characterization of intestinal microbiota in alcoholic patients with and without alcoholic hepatitis or chronic alcoholic pancreatitis. ( 29555983 )
2018
19
Hepatoptosis in a Patient with Alcoholic Hepatitis. ( 29955118 )
2018
20
A return to harmful alcohol consumption impacts on portal hemodynamic changes following alcoholic hepatitis. ( 29727387 )
2018
21
Early liver transplantation for alcoholic hepatitis: Ready for primetime? ( 29175244 )
2018
22
Severe Alcoholic Hepatitis in a Teetotaler. ( 29887602 )
2018
23
Is Granulocyte Colony Stimulating Factor a New Treatment for Alcoholic Hepatitis? ( 29913276 )
2018
24
Baseline urine metabolic phenotype in patients with severe alcoholic hepatitis and its association with outcome. ( 29881815 )
2018
25
Corticosteroids Reduce Risk of Death Within 28 Days for Patients With Severe Alcoholic Hepatitis, Compared With Pentoxifylline or Placebo-a Meta-analysis of Individual Data. ( 29738698 )
2018
26
Alcoholic hepatitis versus non-alcoholic steatohepatitis: Levels of expression of some proteins involved in tumorigenesis. ( 29307797 )
2018
27
Efficacy of Granulocyte Colony Stimulating Factor and N-acetyl Cysteine Therapies in Patients with Severe Alcoholic Hepatitis. ( 29391265 )
2018
28
Corticosteroids, nutrition, pentoxifylline, or fecal microbiota transplantation for severe alcoholic hepatitis. ( 29931479 )
2018
29
Expression of proteins upregulated in hepatocellular carcinoma in patients with alcoholic hepatitis (AH) compared to non-alcoholic steatohepatitis (NASH): An immunohistochemical analysis of candidate proteins. ( 29425759 )
2018
30
Exploring new treatment paradigms for alcoholic hepatitis by extrapolating from NASH and cholestasis. ( 29792896 )
2018
31
Decreased monocyte shedding of the migration inhibitor soluble CD18 in alcoholic hepatitis. ( 29904132 )
2018
32
Advances in the treatment of severe alcoholic hepatitis. ( 29781336 )
2018
33
Iron-Overload triggers ADAM-17 mediated inflammation in Severe Alcoholic Hepatitis. ( 29980709 )
2018
34
Liver transplantation for alcoholic hepatitis: A systematic review with meta-analysis. ( 29324766 )
2018
35
High Mortality in Control Group of Trial of Granulocyte Colony-Stimulating Factor in Alcoholic Hepatitis. ( 29914640 )
2018
36
Alcohol, Diet and Drug Use Preceding Alcoholic Hepatitis. ( 29852499 )
2018
37
The Role of Liver Transplantation in Alcoholic Hepatitis. ( 29879862 )
2018
38
Ginsenoside Rg1 inhibits inflammatory responses via modulation of the nuclear factora89I_B pathway and inhibition of inflammasome activation in alcoholic hepatitis. ( 29207044 )
2018
39
Controversies in clinical trials for alcoholic hepatitis. ( 28966126 )
2018
40
The circulating microbiome signature and inferred functional metagenomics in alcoholic hepatitis. ( 29083504 )
2018
41
Pyroptosis by caspase11/4-gasdermin-D pathway in alcoholic hepatitis in mice and patients. ( 29108122 )
2018
42
Time course of compromised urea synthesis in patients with alcoholic hepatitis. ( 29113530 )
2018
43
Acute alcoholic hepatitis: a literature review and proposal of treatment. ( 29115798 )
2018
44
Molecular Ellipticity of Circulating Albumin-Bilirubin Complex Associates With Mortality in Patients With Severe Alcoholic Hepatitis. ( 29155355 )
2018
45
Combination of Gene Expression Signature and Model for End-Stage Liver Disease Score Predicts Survival of Patients With Severe Alcoholic Hepatitis. ( 29158192 )
2018
46
Extracorporeal cellular therapy (ELAD) in severe alcoholic hepatitis: A multinational, prospective, controlled, randomized trial. ( 29171941 )
2018
47
Extracorporeal liver assist device for alcoholic hepatitis: A potential silver lining? ( 29365343 )
2018
48
Microvesicles in hepatic and peripheral vein can predict nonresponse to corticosteroid therapy in severe alcoholic hepatitis. ( 29460445 )
2018
49
Impact of a first study of early transplantation in acute alcoholic hepatitis: Results of a nationwide survey in french liver transplantation programs. ( 29476690 )
2018
50
Assessment of the risk of alcohol relapse following liver transplantation for alcoholic hepatitis using a meta-analysis approach. ( 29505845 )
2018

Variations for Alcoholic Hepatitis

Expression for Alcoholic Hepatitis

LifeMap Discovery
Genes differentially expressed in tissues of Alcoholic Hepatitis patients vs. healthy controls: 35 (show top 50) (show all 111)
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) Liver + 8.79 0.000
2 KRT23 keratin 23, type I Liver + 7.04 0.000
3 FOS FBJ murine osteosarcoma viral oncogene homolog Liver - 6.75 0.000
4 CCL20 chemokine (C-C motif) ligand 20 Liver + 6.56 0.000
5 KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 Liver - 6.11 0.000
6 SPINK1 serine peptidase inhibitor, Kazal type 1 Liver + 6.07 0.000
7 SPP1 secreted phosphoprotein 1 Liver + 6.04 0.000
8 LCN2 lipocalin 2 Liver + 5.74 0.000
9 CXCL6 chemokine (C-X-C motif) ligand 6 Liver + 5.55 0.000
10 COL1A2 collagen, type I, alpha 2 Liver + 5.33 0.000
11 FOSB FBJ murine osteosarcoma viral oncogene homolog B Liver - 5.08 0.000
12 LOXL4 lysyl oxidase-like 4 Liver + 5.01 0.000
13 PDZK1IP1 PDZK1 interacting protein 1 Liver + 4.95 0.000
14 CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 Liver - 4.91 0.000
15 GOLM1 golgi membrane protein 1 Liver + 4.87 0.000
16 NR4A2 nuclear receptor subfamily 4, group A, member 2 Liver - 4.85 0.000
17 MMP7 matrix metallopeptidase 7 Liver + 4.73 0.000
18 EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 Liver + 4.63 0.000
19 CD24 CD24 molecule Liver + 4.57 0.000
20 GNMT glycine N-methyltransferase Liver - 4.50 0.000
21 PCOLCE2 procollagen C-endopeptidase enhancer 2 Liver - 4.48 0.000
22 CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 Liver - 4.45 0.000
23 TACSTD2 tumor-associated calcium signal transducer 2 Liver + 4.41 0.000
24 DCDC2 doublecortin domain containing 2 Liver + 4.28 0.000
25 EPCAM epithelial cell adhesion molecule Liver + 4.26 0.000
26 NQO1 NAD(P)H dehydrogenase, quinone 1 Liver + 4.10 0.000
27 MT1M metallothionein 1M Liver - 4.07 0.000
28 SOX9 SRY (sex determining region Y)-box 9 Liver + 3.99 0.000
29 THBS2 thrombospondin 2 Liver + 3.98 0.000
30 KRT7 keratin 7, type II Liver + 3.96 0.000
31 BICC1 BicC family RNA binding protein 1 Liver + 3.96 0.000
32 FABP4 fatty acid binding protein 4, adipocyte Liver + 3.94 0.000
33 IL32 interleukin 32 Liver + 3.94 0.000
34 PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A Liver - 3.91 0.000
35 RRM2 ribonucleotide reductase M2 Liver + 3.90 0.000
36 CXCL8 chemokine (C-X-C motif) ligand 8 Liver + 3.90 0.000
37 VCAN versican Liver + 3.90 0.000
38 COL1A1 collagen, type I, alpha 1 Liver + 3.89 0.000
39 DUSP1 dual specificity phosphatase 1 Liver - 3.89 0.000
40 LGSN lengsin, lens protein with glutamine synthetase domain Liver - 3.78 0.000
41 COL5A1 collagen, type V, alpha 1 Liver + 3.77 0.000
42 SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 Liver - 3.77 0.000
43 RGS4 regulator of G-protein signaling 4 Liver + 3.76 0.000
44 STMN2 stathmin 2 Liver + 3.72 0.000
45 SOX4 SRY (sex determining region Y)-box 4 Liver + 3.71 0.000
46 CLEC4M C-type lectin domain family 4, member M Liver - 3.69 0.000
47 ANXA2 annexin A2 Liver + 3.67 0.000
48 ANXA2P2 annexin A2 pseudogene 2 Liver + 3.66 0.000
49 CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family) Liver - 3.65 0.000
50 GPR88 G protein-coupled receptor 88 Liver - 3.64 0.000
Search GEO for disease gene expression data for Alcoholic Hepatitis.

Pathways for Alcoholic Hepatitis

Pathways related to Alcoholic Hepatitis according to GeneCards Suite gene sharing:

(show all 50)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.5 CCL2 CXCL8 F2 ICAM1 IL10 IL22
2
Show member pathways
13.27 CCL2 CXCL8 ICAM1 IL10 IL22 IL6
3
Show member pathways
13.24 CCL2 CXCL8 IL10 IL22 IL6 TNF
4
Show member pathways
12.99 CCL2 CXCL8 ICAM1 IL6 TNF
5
Show member pathways
12.98 CCL2 CXCL8 IL10 IL6 LBP TNF
6
Show member pathways
12.84 CXCL8 ICAM1 IL10 IL22 IL6 TNF
7
Show member pathways
12.77 CCL2 CXCL8 ICAM1 IL6 TNF
8
Show member pathways
12.57 CCL2 F2 IL10 IL6 TNF
9
Show member pathways
12.54 IL10 IL22 IL6 TNF
10
Show member pathways
12.31 CCL2 CXCL8 IL6 TNF
11
Show member pathways
12.28 CXCL8 IL6 LBP TNF
12 12.22 IL10 IL6 LBP TNF
13
Show member pathways
12.21 CXCL8 IL10 IL6 TNF
14
Show member pathways
12.18 CXCL8 IL6 LBP TNF
15
Show member pathways
12.18 ALB CCL2 F2 ICAM1 IL6 TNF
16 12.17 CXCL8 IL10 IL6 TNF
17
Show member pathways
12.04 IL10 IL22 IL6 TNF
18
Show member pathways
11.98 F2 IL6 TNF
19
Show member pathways
11.97 CCL2 CXCL8 ICAM1 IL10 IL22 IL6
20 11.95 CCL2 ICAM1 IL6 TNF
21 11.94 IL10 IL6 TNF
22 11.93 CCL2 CXCL8 ICAM1 IL6 TNF
23 11.87 CXCL8 IL10 IL6 TNF
24 11.86 CXCL8 ICAM1 LBP TNF
25
Show member pathways
11.85 CXCL8 ICAM1 IL6 LBP
26 11.8 CXCL8 IL6 LBP
27 11.8 CCL2 CXCL8 ICAM1 IL6 TNF
28 11.78 CXCL8 ICAM1 IL6
29 11.77 IL10 IL22 TNF
30 11.73 IL10 IL6 TNF
31 11.72 CXCL8 IL10 IL6 TNF
32 11.68 CCL2 IL10 IL6 TNF
33 11.67 CCL2 CXCL8 ICAM1 IL6 TNF
34 11.61 CCL2 CXCL8 IL6 TNF
35
Show member pathways
11.6 CXCL8 ICAM1 IL6 TNF
36 11.59 CXCL8 IL6 TNF
37 11.52 ICAM1 IL6 TNF
38 11.37 IL10 IL6 TNF
39 11.35 CCL2 CXCL8 IL6
40 11.32 CCL2 CXCL8 ICAM1 IL10 IL6 TNF
41 11.31 IL22 IL6 TNF
42 11.28 ICAM1 IL10 IL6 TNF
43 11.26 IL10 IL6 TNF
44 11.22 CCL2 CXCL8 ICAM1 IL10 IL6 LBP
45 11.18 CCL2 F2 ICAM1
46 11.12 CCL2 CXCL8 ICAM1 IL10 IL6 TNF
47 11.02 CXCL8 IL6 TNF
48 10.98 CCL2 CXCL8 IL10 IL22 IL6 TNF
49 10.96 CCL2 CXCL8 IL10 IL22 IL6 TNF
50 10.93 CCL2 ICAM1 TNF

GO Terms for Alcoholic Hepatitis

Cellular components related to Alcoholic Hepatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 ADAMTS13 ALB CCL2 CXCL8 F2 IL10
2 endoplasmic reticulum lumen GO:0005788 9.46 ADAMTS13 ALB F2 IL6
3 extracellular space GO:0005615 9.4 ADAMTS13 ALB CCL2 CXCL8 F2 GPT

Biological processes related to Alcoholic Hepatitis according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.97 CCL2 CXCL8 IL10 IL6 TNF
2 positive regulation of DNA-binding transcription factor activity GO:0051091 9.81 IL10 IL6 TNF
3 response to bacterium GO:0009617 9.8 CCL2 CYP2E1 SLC17A5
4 platelet activation GO:0030168 9.8 ADAMTS13 F2 IL6
5 inflammatory response GO:0006954 9.8 CCL2 CXCL8 IL10 IL22 IL6 TNF
6 cellular response to interferon-gamma GO:0071346 9.79 ADAMTS13 CCL2 ICAM1
7 defense response to Gram-positive bacterium GO:0050830 9.79 IL6 LBP TNF
8 cellular response to interleukin-1 GO:0071347 9.77 CCL2 CXCL8 ICAM1
9 cellular response to tumor necrosis factor GO:0071356 9.76 ADAMTS13 CCL2 CXCL8 ICAM1
10 positive regulation of interleukin-6 production GO:0032755 9.7 IL6 LBP TNF
11 regulation of signaling receptor activity GO:0010469 9.7 CCL2 CXCL8 F2 IL10 IL22 IL6
12 humoral immune response GO:0006959 9.69 CCL2 IL6 TNF
13 response to glucocorticoid GO:0051384 9.67 IL10 IL22 IL6 TNF
14 embryonic digestive tract development GO:0048566 9.65 CXCL8 TNF
15 positive regulation of glial cell proliferation GO:0060252 9.65 IL6 TNF
16 lipopolysaccharide-mediated signaling pathway GO:0031663 9.65 CCL2 LBP TNF
17 positive regulation of macrophage activation GO:0043032 9.64 IL10 LBP
18 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.63 IL10 TNF
19 PERK-mediated unfolded protein response GO:0036499 9.61 CCL2 CXCL8
20 positive regulation of chemokine production GO:0032722 9.61 IL6 LBP TNF
21 response to molecule of bacterial origin GO:0002237 9.6 CXCL8 IL10
22 negative regulation of lipid storage GO:0010888 9.58 IL6 TNF
23 endothelial cell apoptotic process GO:0072577 9.58 IL10 TNF
24 negative regulation of growth of symbiont in host GO:0044130 9.58 IL10 LBP TNF
25 negative regulation of cytokine secretion involved in immune response GO:0002740 9.56 IL10 TNF
26 acute-phase response GO:0006953 9.56 F2 IL22 IL6 LBP
27 cytokine-mediated signaling pathway GO:0019221 9.56 CCL2 CXCL8 ICAM1 IL10 IL22 IL6
28 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.55 ICAM1 TNF
29 positive regulation of neuroinflammatory response GO:0150078 9.54 IL6 TNF
30 receptor biosynthetic process GO:0032800 9.49 IL10 TNF
31 cellular response to lipopolysaccharide GO:0071222 9.23 ADAMTS13 CCL2 CXCL8 ICAM1 IL10 IL6

Molecular functions related to Alcoholic Hepatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 CCL2 CXCL8 IL10 IL22 IL6 TNF

Sources for Alcoholic Hepatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
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37 KEGG
38 LifeMap
40 LOVD
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44 MeSH
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62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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