MCID: ALC006
MIFTS: 62

Alcoholic Hepatitis

Categories: Gastrointestinal diseases, Endocrine diseases, Liver diseases

Aliases & Classifications for Alcoholic Hepatitis

MalaCards integrated aliases for Alcoholic Hepatitis:

Name: Alcoholic Hepatitis 38 12 76 15
Acute Alcoholic Liver Disease 12 73
Acute Alcoholic Hepatitis 12 55
Hepatitis, Alcoholic 73
Hepatitis Alcoholic 55

Classifications:



External Ids:

Disease Ontology 12 DOID:12351
ICD9CM 35 571.1
NCIt 50 C34352
SNOMED-CT 68 155810001 9953008
ICD10 33 K70.1

Summaries for Alcoholic Hepatitis

MalaCards based summary : Alcoholic Hepatitis, also known as acute alcoholic liver disease, is related to hepatitis and hepatitis a. An important gene associated with Alcoholic Hepatitis is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways are TGF-Beta Pathway and Cytokine Signaling in Immune system. The drugs Ethanol and Metformin have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and neutrophil, and related phenotypes are homeostasis/metabolism and liver/biliary system

Wikipedia : 76 Alcoholic hepatitis is hepatitis (inflammation of the liver) due to excessive intake of alcohol. It is... more...

Related Diseases for Alcoholic Hepatitis

Diseases related to Alcoholic Hepatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 317)
# Related Disease Score Top Affiliating Genes
1 hepatitis 31.6 F2 GPT SLC17A5 TNF
2 hepatitis a 30.7 ALB F2 GPT TNF
3 fatty liver disease 30.5 CYP2E1 GPT IL6 KRT18 SLC17A5 TNF
4 hepatic coma 29.9 ALB F2 GPT
5 hepatitis e 29.8 ALB F2 GPT TNF
6 portal hypertension 29.7 ALB F2 GPT TNF
7 acute liver failure 29.7 ALB F2 GPT SLC17A5
8 alcohol abuse 29.6 CYP2E1 GPT SLC17A5
9 hepatitis b 29.6 ALB F2 GPT SLC17A5 TNF
10 protein-energy malnutrition 29.4 ALB GPT IL6 TNF
11 alcoholic liver cirrhosis 29.4 ALB CXCL8 CYP2E1 F2 SLC17A5
12 acute pancreatitis 29.4 CXCL8 IL10 IL6
13 nonalcoholic steatohepatitis 29.3 F2 GPT KRT18 SLC17A5 TNF
14 prostatitis 29.2 CXCL8 IL10 IL6 TNF
15 liver cirrhosis 29.0 ALB CYP2E1 F2 GPT SLC17A5
16 hepatic encephalopathy 28.9 ALB F2 GPT IL6 SLC17A5 TNF
17 liver disease 28.4 ALB CYP2E1 F2 GPT KRT18 SLC17A5
18 viral hepatitis 28.1 ALB F2 GPT KRT18 SLC17A5 TNF
19 pneumonia 28.0 CCL2 CXCL8 IL10 IL6 TNF
20 diabetes mellitus, noninsulin-dependent 27.4 ALB CCL2 GPT IL6 SLC17A5 TNF
21 peritonitis 25.5 ALB CCL2 CXCL8 F2 ICAM1 IL10
22 scorpion envenomation 10.9 IL6 TNF
23 antipyrine metabolism 10.9 ALB F2
24 non-a-e hepatitis 10.9 ALB F2
25 marburg hemorrhagic fever 10.9 F2 TNF
26 leukomalacia 10.8 IL6 TNF
27 angioimmunoblastic lymphadenopathy with dysproteinemia 10.8 IL6 TNF
28 recurrent corneal erosion 10.8 CXCL8 IL6
29 bagassosis 10.8 CXCL8 IL6
30 sudden sensorineural hearing loss 10.8 F2 IL6
31 fournier gangrene 10.8 ALB F2
32 critical limb ischemia 10.8 IL6 TNF
33 toxicodendron dermatitis 10.8 CXCL8 ICAM1
34 null-cell leukemia 10.7 IL6 TNF
35 abdominal tuberculosis 10.7 ALB F2
36 streptococcal toxic-shock syndrome 10.7 CXCL8 IL6 TNF
37 ischemic heart disease 10.7 F2 IL6 TNF
38 pyuria 10.7 ALB CXCL8
39 meconium aspiration syndrome 10.7 CXCL8 IL6 TNF
40 louse-borne relapsing fever 10.7 CXCL8 IL6 TNF
41 paraquat poisoning 10.7 GPT SLC17A5
42 hepatoportal sclerosis 10.7 F2 GPT
43 pulpitis 10.7 CXCL8 IL6 TNF
44 perinatal necrotizing enterocolitis 10.7 CXCL8 IL6 TNF
45 fasciitis 10.7 CXCL8 IL6 TNF
46 uterine anomalies 10.6 CXCL8 IL6 TNF
47 endometritis 10.6 IL6 SLC17A5 TNF
48 retinitis pigmentosa 55 10.6 IL6 TNF
49 acute respiratory distress syndrome 10.6 CXCL8 IL6 TNF
50 bacterial vaginosis 10.6 CXCL8 IL6 TNF

Comorbidity relations with Alcoholic Hepatitis via Phenotypic Disease Network (PDN): (show all 12)


Active Peptic Ulcer Disease Acute Cystitis
Acute Pancreatitis Alcohol Abuse
Alcoholic Gastritis Alcoholic Liver Cirrhosis
Alcoholic Neuropathy Deficiency Anemia
Fatty Liver Disease Hepatic Encephalopathy
Portal Hypertension Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Alcoholic Hepatitis:



Diseases related to Alcoholic Hepatitis

Symptoms & Phenotypes for Alcoholic Hepatitis

MGI Mouse Phenotypes related to Alcoholic Hepatitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.85 ICAM1 IL10 IL6 LBP SLC17A5 TNF
2 liver/biliary system MP:0005370 9.5 IL10 IL6 KRT18 LBP TNF ALB
3 neoplasm MP:0002006 9.1 ICAM1 IL10 IL6 TNF ALB CYP2E1

Drugs & Therapeutics for Alcoholic Hepatitis

Drugs for Alcoholic Hepatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 135)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 64-17-5 702
2
Metformin Approved Phase 4 657-24-9 14219 4091
3
Pentoxifylline Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 6493-05-6 4740
4
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 135968-09-1
5
Prednisone Approved, Vet_approved Phase 4,Phase 2 53-03-2 5865
6
Caspofungin Approved Phase 4 179463-17-3, 162808-62-0 468682 2826718
7
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
8
Acetylcysteine Approved, Investigational Phase 4,Phase 3 616-91-1 12035
9
Choline Approved, Nutraceutical Phase 4 62-49-7 305
10
Methionine Approved, Nutraceutical Phase 4,Phase 2 63-68-3 6137
11
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 59-30-3 6037
12
Pyridoxal Approved, Nutraceutical Phase 4,Phase 2 66-72-8 1050
13
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 2 65-23-6 1054
14
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
15 Antimetabolites Phase 4
16 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
17 Hypolipidemic Agents Phase 4
18 Lipid Regulating Agents Phase 4
19 Nootropic Agents Phase 4
20 Polyene phosphatidylcholine Phase 4
21 Liver Extracts Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
22 Metadoxine Phase 4,Phase 2
23 Micronutrients Phase 4,Phase 3,Phase 2
24 Trace Elements Phase 4,Phase 3,Phase 2
25 Vitamin B 6 Phase 4,Phase 2
26 Vitamin B Complex Phase 4,Phase 2
27 Vitamins Phase 4,Phase 3,Phase 2
28 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
29 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
30 Antioxidants Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
31 glucocorticoids Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
32 Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
33 Hormones Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
34 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
35 Phosphodiesterase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
36 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
37 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
38 Radiation-Protective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
39 Vasodilator Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
40 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
41 Adjuvants, Immunologic Phase 4,Phase 3,Phase 2,Not Applicable
42 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
43 Antifungal Agents Phase 4
44 Echinocandins Phase 4
45 Anti-Infective Agents, Local Phase 4,Not Applicable
46 Central Nervous System Depressants Phase 4,Not Applicable
47 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3,Not Applicable
48 Antidotes Phase 4,Phase 3
49 Antiviral Agents Phase 4,Phase 3
50 diuretics Phase 4,Phase 2,Phase 3

Interventional clinical trials:

(show top 50) (show all 80)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of S-adenosyl-l-methionine in Treatment of Alcoholic Hepatitis With Cholestasis Unknown status NCT02024295 Phase 4 Ademethionine;Polyene Phosphatidyl choline;Ademethionine
2 Effect of Probiotics on Gut-Liver Axis of Alcoholic Hepatitis Unknown status NCT02335632 Phase 4 Probiotics (Lacidofil®);Placebo
3 Effect of Metadoxine on Oxidative Stress in Non-alcoholic Hepatic Steatosis Unknown status NCT02051842 Phase 4 Metadoxine
4 Metadoxine as a Therapy for Severe Alcoholic Hepatitis Completed NCT02161653 Phase 4 Prednisone plus Metadoxine;Pentoxifylline plus Metadoxine
5 Pharmacokinetics of Caspofungin After One Dose in Patients With Liver Failure Completed NCT01968395 Phase 4 Caspofungin 70 mg
6 The Effect of High Dose Vitamin C on the Liver Function in Chronic Hepatitis Patients Completed NCT01413360 Phase 4 High dose vitamin C
7 Effect of Probiotics on Gut-Liver Axis of Alcoholic Liver Disease Completed NCT01501162 Phase 4 hepatitis, alcohol, probiotics;alcohol, hepatitis, Placebo
8 G-CSF Plus NAC In Severe Alcoholic Hepatitis Recruiting NCT02971306 Phase 4 standard medical therapy;G-CSF;n-Acetylcysteine
9 Rifaximin Use in Severe Alcoholic Hepatitis Unknown status NCT02485106 Phase 3 Rifaximin;Corticosteroid or pentoxifylline
10 Short-term Survival in Patients With Severe Alcoholic Hepatitis Treated With Steroid Versus Pentoxifylline Unknown status NCT01455337 Phase 3 pentoxifylline;Prednisolone
11 Probiotics for Portal Hypertension Unknown status NCT01134692 Phase 3 Propranolol, Norfloxacin, VSL#3
12 N-Acetylcysteine in Severe Acute Alcoholic Hepatitis Completed NCT00962442 Phase 3 N-Acetylcysteine;placebo
13 Treatment of Severe Alcoholic Hepatitis With Corticoids Plus N Acetyl Cysteine Versus Corticoids Alone Completed NCT00863785 Phase 3 Corticoids plus N Acetyl Cysteine
14 Double-blind Randomized Controlled Trial in Severe Alcoholic Hepatitis Completed NCT01214226 Phase 3 Pentoxifylline;placebo
15 Assess Safety and Efficacy of ELAD (Extracorporeal Liver Assist System) in Subjects With Alcohol-Induced Liver Failure Completed NCT01471028 Phase 3
16 Trial for Hepatocellular Carcinoma Adjuvant Treatment by Lipiocis Completed NCT00116454 Phase 3 131 I-lipiodol
17 Efficacy and Safety of the Extracorporeal Liver Assist Device (ELAD) in Acute on Chronic Hepatitis Completed NCT00973817 Phase 2, Phase 3
18 Efficacy of Granulocyte Colony-stimulating Factor and Erythropoetin for Patients With Acute-on-chronic Liver Failure Completed NCT01383460 Phase 3 Granulocyte Colony-stimulating Factor (G-CSF) and Erythropoetin (EPO);Placebo
19 Granulocyte Colony Stimulating Factor And Growth Hormone In Cirrhosis Of Liver: An Open Label Study Completed NCT02451033 Phase 2, Phase 3 standard medical therapy;G-CSF;Growth Hormone
20 A Placebo-Controlled, Double-Blind Study to Confirm the Reversal of Hepatorenal Syndrome Type 1 With Terlipressin Completed NCT01143246 Phase 3 Terlipressin;Placebo
21 Efficacy and Safety of G-CSF in Patients With Severe Alcoholic Hepatitis With Null or Partial Response to Steroid Recruiting NCT02442180 Phase 3 G-CSF (Filgrastim injection);steroid;placebo
22 Comparison of Bovine Colostrum Versus Placebo in Treatment of Severe Alcoholic Hepatitis: A Randomized Double Blind Controlled Trial Recruiting NCT02473341 Phase 3 Bovine Colostrum;Placebo
23 Efficacy of Antibiotic Therapy in Severe Alcoholic Hepatitis Treated With Prednisolone Recruiting NCT02281929 Phase 3 Amoxicillin;Placebo;Prednisolone
24 Efficacy Study of Anakinra, Pentoxifylline, and Zinc Compared to Methylprednisolone in Severe Acute Alcoholic Hepatitis Recruiting NCT01809132 Phase 2, Phase 3 Anakinra;Pentoxifylline;Zinc Sulfate;Methylprednisolone
25 N-ACetylcysteine to Reduce Infection and Mortality for Alcoholic Hepatitis Recruiting NCT03069300 Phase 3 N-acetyl cysteine (NAC)
26 Randomized, Open-Label, Multicenter, Controlled, Pivotal Study to Assess Safety and Efficacy of ELAD in Subjects w/ AILD Active, not recruiting NCT02612428 Phase 3
27 Study to Assess Safety and Efficacy of ELAD in Subjects With Severe Acute Alcoholic Hepatitis (sAAH) and Lille Score Failure Terminated NCT01829347 Phase 3
28 Registry Protocol for Tracking Trial Subjects After VTI-206 Study Completion Withdrawn NCT01452295 Phase 2, Phase 3 ELAD (Extracorporeal Liver Assist System)
29 A Safety and Efficacy Study of Mycophenolate Mofetil and Rilonacept in Patients With Alcoholic Hepatitis Completed NCT01903798 Phase 2 Rilonacept;Mycophenolate mofetil;Prednisolone
30 Efficacy of Combination Therapy of Glucocorticoids and Bovine Colostrum in Treatment of Severe Alcoholic Hepatitis. Completed NCT02265328 Phase 2
31 Selonsertib in Combination With Prednisolone Versus Prednisolone Alone in Participants With Severe Alcoholic Hepatitis (AH) Completed NCT02854631 Phase 2 Selonsertib;Prednisolone;Placebo
32 Efficacy and Safety of MG in the Patients With Alcoholic Fatty Liver Disease and Alcoholic Hepatitis Completed NCT02019056 Phase 2 Placebo /bid P.O;MG-1;MG-2 : MG1000mg, Placebo /bid P.O;metadoxine
33 Randomized, Controlled Trial of S-adenosylmethionine in Alcoholic Liver Disease Completed NCT00851981 Phase 2
34 Treating Nonalcoholic Steatohepatitis With Pioglitazone Completed NCT00062764 Phase 2 Actos (Pioglitazone)
35 A Research Study to Assess the Safety, Pharmacokinetics and Pharmacodynamics of DUR-928 in Patients With Alcoholic Hepatitis Recruiting NCT03432260 Phase 2 DUR-928
36 Use of F-652 in Patients With Alcoholic Hepatitis Recruiting NCT02655510 Phase 1, Phase 2 F-652
37 Pegfilgrastim in Patients With Alcoholic Hepatitis Recruiting NCT02776059 Phase 2 Standard of care + pegfiltrastim;Standard of care
38 Trial of Obeticholic Acid in Patients With Moderately Severe Alcoholic Hepatitis (AH) Recruiting NCT02039219 Phase 2 Placebo;10 mg Obeticholic Acid (OCA)
39 Safety and Efficacy of IMM 124-E for Patients With Severe Alcoholic Hepatitis Recruiting NCT01968382 Phase 2 IMM 124-E (Hyperimmune Bovine Colostrum);Placebo (High protein milk powder)
40 Effects of Rifaximin in Patients With Acute Alcoholic Hepatitis Enrolling by invitation NCT02116556 Phase 2 Prednisone;Rifaximin
41 Efficacy and Safety of Orally Administered DS102 in Patients With Acute Alcoholic Hepatitis Not yet recruiting NCT03452540 Phase 2 DS102
42 Study of IDN-6556 in Patients With Severe Alcoholic Hepatitis and Contraindications to Steroid Therapy Terminated NCT01912404 Phase 2 IDN-6556;Placebo
43 Pharmacokinetic and Pharmacodynamic Study of IDN-6556 in ACLF Terminated NCT01937130 Phase 2 IDN-6556
44 Treatment of Alcohol-Related Hepatitis With Arginine Withdrawn NCT00200746 Phase 2 Arginine
45 Fecal Microbial Transplant for Alcohol Misuse in Cirrhosis Recruiting NCT03416751 Phase 1
46 Pentoxifylline for Acute Alcoholic Hepatitis (AAH) Terminated NCT00205049 Phase 1 pentoxifylline
47 Pilot Study of Pentoxifylline for Hepatopulmonary Syndrome Terminated NCT00593658 Phase 1 pentoxifylline
48 Granulocyte Colony Stimulating Factor (G-CSF) in Acute Liver Failure and Alcoholic Hepatitis Unknown status NCT01341951 Not Applicable Granulocyte colony stimulating factor
49 Effects of Prednisolone and Pentoxifylline on the Regulation of Urea Synthesis in Alcoholic Hepatitis Completed NCT01245257
50 Assessment of the Predictive Value of Fecal Calprotectin for the Outcome of Severe Alcoholic Hepatitis Completed NCT02808663 Not Applicable

Search NIH Clinical Center for Alcoholic Hepatitis

Genetic Tests for Alcoholic Hepatitis

Anatomical Context for Alcoholic Hepatitis

MalaCards organs/tissues related to Alcoholic Hepatitis:

41
Liver, Brain, Neutrophil, T Cells, Monocytes, Adipocyte, Colon

Publications for Alcoholic Hepatitis

Articles related to Alcoholic Hepatitis:

(show top 50) (show all 692)
# Title Authors Year
1
Knockout of microRNA-21 attenuates alcoholic hepatitis through VHL/NF-I_B signaling pathway in hepatic stellate cells. ( 29848019 )
2018
2
Can we reliably predict response to corticosteroid treatment in severe alcoholic hepatitis? ( 29881814 )
2018
3
Role of liver transplantation in severe alcoholic hepatitis. ( 29316778 )
2018
4
A new marker for severity of alcoholic hepatitis. ( 29427735 )
2018
5
Modification Patterns of Urinary Albumin Correlates With Serum Albumin and Outcome in Severe Alcoholic Hepatitis. ( 29369844 )
2018
6
Liver Transplantation for Severe Alcoholic Hepatitis, Updated Lessons from the World's Largest Series. ( 29409981 )
2018
7
People who survive an episode of severe alcoholic hepatitis should be advised to maintain total abstinence from alcohol. ( 29394458 )
2018
8
Survival from alcoholic hepatitis has not improved over time. ( 29444123 )
2018
9
Grand Rounds: Alcoholic Hepatitis. ( 29753761 )
2018
10
Alcoholic steatohepatitis (ASH) and alcoholic hepatitis (AH): cascade of events, clinical aspects, and pharmacotherapy options. ( 29708448 )
2018
11
Early liver transplantation for severe alcoholic hepatitis: moving from controversy to consensus. ( 29389821 )
2018
12
Malnutrition is a key prognostic factor related to high mortality-rate in patients with severe alcoholic hepatitis. ( 29974779 )
2018
13
Interaction between the patatin-like phospholipase domain-containing protein 3 genotype and coffee drinking and the risk for acute alcoholic hepatitis. ( 29404510 )
2018
14
<i>In vivo</i> imaging of hepatic neutrophil migration in severe alcoholic hepatitis with <sup>111</sup>In-radiolabelled leucocytes. ( 29700216 )
2018
15
More than meets the eye: Severe alcoholic hepatitis can present as acute-on-chronic liver failure. ( 29935965 )
2018
16
Extracorporeal Cellular Therapy (ELAD) in Severe Alcoholic Hepatitis- A Multinational, Prospective, Controlled, Randomized Trial. ( 29385313 )
2018
17
Characterization of intestinal microbiota in alcoholic patients with and without alcoholic hepatitis or chronic alcoholic pancreatitis. ( 29555983 )
2018
18
Hepatoptosis in a Patient with Alcoholic Hepatitis. ( 29955118 )
2018
19
A return to harmful alcohol consumption impacts on portal hemodynamic changes following alcoholic hepatitis. ( 29727387 )
2018
20
Early liver transplantation for alcoholic hepatitis: Ready for primetime? ( 29175244 )
2018
21
Severe Alcoholic Hepatitis in a Teetotaler. ( 29887602 )
2018
22
Is Granulocyte Colony Stimulating Factor a New Treatment for Alcoholic Hepatitis? ( 29913276 )
2018
23
Non-alcoholic hepatic steatosis attenuates hepatitis B virus replication in an HBV-immunocompetent mouse model. ( 29974410 )
2018
24
Baseline urine metabolic phenotype in patients with severe alcoholic hepatitis and its association with outcome. ( 29881815 )
2018
25
Corticosteroids Reduce Risk of Death Within 28 Days for Patients With Severe Alcoholic Hepatitis, Compared With Pentoxifylline or Placebo-a Meta-analysis of Individual Data. ( 29738698 )
2018
26
Alcoholic hepatitis versus non-alcoholic steatohepatitis: Levels of expression of some proteins involved in tumorigenesis. ( 29307797 )
2018
27
Efficacy of Granulocyte Colony Stimulating Factor and N-acetyl Cysteine Therapies in Patients with Severe Alcoholic Hepatitis. ( 29391265 )
2018
28
Corticosteroids, nutrition, pentoxifylline, or fecal microbiota transplantation for severe alcoholic hepatitis. ( 29931479 )
2018
29
Expression of proteins upregulated in hepatocellular carcinoma in patients with alcoholic hepatitis (AH) compared to non-alcoholic steatohepatitis (NASH): An immunohistochemical analysis of candidate proteins. ( 29425759 )
2018
30
Exploring new treatment paradigms for alcoholic hepatitis by extrapolating from NASH and cholestasis. ( 29792896 )
2018
31
Decreased monocyte shedding of the migration inhibitor soluble CD18 in alcoholic hepatitis. ( 29904132 )
2018
32
Advances in the treatment of severe alcoholic hepatitis. ( 29781336 )
2018
33
Iron-Overload triggers ADAM-17 mediated inflammation in Severe Alcoholic Hepatitis. ( 29980709 )
2018
34
Liver transplantation for alcoholic hepatitis: A systematic review with meta-analysis. ( 29324766 )
2018
35
High Mortality in Control Group of Trial of Granulocyte Colony-Stimulating Factor in Alcoholic Hepatitis. ( 29914640 )
2018
36
Alcohol, Diet and Drug Use Preceding Alcoholic Hepatitis. ( 29852499 )
2018
37
The Role of Liver Transplantation in Alcoholic Hepatitis. ( 29879862 )
2018
38
Ginsenoside Rg1 inhibits inflammatory responses via modulation of the nuclear factora89I_B pathway and inhibition of inflammasome activation in alcoholic hepatitis. ( 29207044 )
2018
39
Clinical Trial Design for Alcoholic Hepatitis. ( 29272895 )
2017
40
Pre-therapy liver transcriptome landscape in Indian and French patients with severe alcoholic hepatitis and steroid responsiveness. ( 28754919 )
2017
41
Transjugular liver biopsy in severe alcoholic hepatitis. ( 28050823 )
2017
42
Review article: recent insights into clinical decision-making in severe alcoholic hepatitis. ( 28543549 )
2017
43
Alcohol abstinence in patients surviving an episode of alcoholic hepatitis: Prediction and impact on long-term survival. ( 28646515 )
2017
44
Hyperoxidized albumin modulates neutrophils to induce oxidative stress and inflammation in severe alcoholic hepatitis. ( 27775820 )
2017
45
Adult-onset Still's disease-like condition due to alcoholic hepatitis and vitamin B deficiency. ( 28691376 )
2017
46
Severe Alcoholic Hepatitis: Atypical Presentation with Markedly Elevated Alkaline Phosphatase. ( 29226108 )
2017
47
Treatment of severe alcoholic hepatitis: past, present and future. ( 28517024 )
2017
48
Homozygosity for rs738409:G in PNPLA3 is associated with increased mortality following an episode of severe alcoholic hepatitis. ( 28161471 )
2017
49
Acute alcoholic hepatitis and liver transplantation: Waiting for Godot. ( 28845615 )
2017
50
Plasma biomarkers to diagnose alcoholic hepatitis - are we there yet? ( 28941362 )
2017

Variations for Alcoholic Hepatitis

Expression for Alcoholic Hepatitis

LifeMap Discovery
Genes differentially expressed in tissues of Alcoholic Hepatitis patients vs. healthy controls: 35 (show top 50) (show all 111)
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) Liver + 8.79 0.000
2 KRT23 keratin 23, type I Liver + 7.04 0.000
3 FOS FBJ murine osteosarcoma viral oncogene homolog Liver - 6.75 0.000
4 CCL20 chemokine (C-C motif) ligand 20 Liver + 6.56 0.000
5 KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 Liver - 6.11 0.000
6 SPINK1 serine peptidase inhibitor, Kazal type 1 Liver + 6.07 0.000
7 SPP1 secreted phosphoprotein 1 Liver + 6.04 0.000
8 LCN2 lipocalin 2 Liver + 5.74 0.000
9 CXCL6 chemokine (C-X-C motif) ligand 6 Liver + 5.55 0.000
10 COL1A2 collagen, type I, alpha 2 Liver + 5.33 0.000
11 FOSB FBJ murine osteosarcoma viral oncogene homolog B Liver - 5.08 0.000
12 LOXL4 lysyl oxidase-like 4 Liver + 5.01 0.000
13 PDZK1IP1 PDZK1 interacting protein 1 Liver + 4.95 0.000
14 CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 Liver - 4.91 0.000
15 GOLM1 golgi membrane protein 1 Liver + 4.87 0.000
16 NR4A2 nuclear receptor subfamily 4, group A, member 2 Liver - 4.85 0.000
17 MMP7 matrix metallopeptidase 7 Liver + 4.73 0.000
18 EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 Liver + 4.63 0.000
19 CD24 CD24 molecule Liver + 4.57 0.000
20 GNMT glycine N-methyltransferase Liver - 4.50 0.000
21 PCOLCE2 procollagen C-endopeptidase enhancer 2 Liver - 4.48 0.000
22 CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 Liver - 4.45 0.000
23 TACSTD2 tumor-associated calcium signal transducer 2 Liver + 4.41 0.000
24 DCDC2 doublecortin domain containing 2 Liver + 4.28 0.000
25 EPCAM epithelial cell adhesion molecule Liver + 4.26 0.000
26 NQO1 NAD(P)H dehydrogenase, quinone 1 Liver + 4.10 0.000
27 MT1M metallothionein 1M Liver - 4.07 0.000
28 SOX9 SRY (sex determining region Y)-box 9 Liver + 3.99 0.000
29 THBS2 thrombospondin 2 Liver + 3.98 0.000
30 KRT7 keratin 7, type II Liver + 3.96 0.000
31 BICC1 BicC family RNA binding protein 1 Liver + 3.96 0.000
32 FABP4 fatty acid binding protein 4, adipocyte Liver + 3.94 0.000
33 IL32 interleukin 32 Liver + 3.94 0.000
34 PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A Liver - 3.91 0.000
35 RRM2 ribonucleotide reductase M2 Liver + 3.90 0.000
36 CXCL8 chemokine (C-X-C motif) ligand 8 Liver + 3.90 0.000
37 VCAN versican Liver + 3.90 0.000
38 COL1A1 collagen, type I, alpha 1 Liver + 3.89 0.000
39 DUSP1 dual specificity phosphatase 1 Liver - 3.89 0.000
40 LGSN lengsin, lens protein with glutamine synthetase domain Liver - 3.78 0.000
41 COL5A1 collagen, type V, alpha 1 Liver + 3.77 0.000
42 SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 Liver - 3.77 0.000
43 RGS4 regulator of G-protein signaling 4 Liver + 3.76 0.000
44 STMN2 stathmin 2 Liver + 3.72 0.000
45 SOX4 SRY (sex determining region Y)-box 4 Liver + 3.71 0.000
46 CLEC4M C-type lectin domain family 4, member M Liver - 3.69 0.000
47 ANXA2 annexin A2 Liver + 3.67 0.000
48 ANXA2P2 annexin A2 pseudogene 2 Liver + 3.66 0.000
49 CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family) Liver - 3.65 0.000
50 GPR88 G protein-coupled receptor 88 Liver - 3.64 0.000
Search GEO for disease gene expression data for Alcoholic Hepatitis.

Pathways for Alcoholic Hepatitis

Pathways related to Alcoholic Hepatitis according to GeneCards Suite gene sharing:

(show all 46)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.46 CCL2 CXCL8 F2 IL10 IL22 IL6
2
Show member pathways
13.26 CCL2 CXCL8 ICAM1 IL10 IL22 IL6
3
Show member pathways
13.23 CCL2 CXCL8 IL10 IL22 IL6 TNF
4
Show member pathways
12.97 CCL2 CXCL8 IL10 IL6 LBP TNF
5
Show member pathways
12.83 CXCL8 ICAM1 IL10 IL22 IL6 TNF
6
Show member pathways
12.76 CCL2 CXCL8 ICAM1 IL6 TNF
7
Show member pathways
12.59 CXCL8 IL10 IL22 IL6 TNF
8
Show member pathways
12.56 CCL2 F2 IL10 IL6 TNF
9
Show member pathways
12.51 CXCL8 ICAM1 IL6 TNF
10
Show member pathways
12.41 IL10 IL22 IL6 TNF
11
Show member pathways
12.3 CCL2 CXCL8 IL6 TNF
12
Show member pathways
12.25 CXCL8 IL6 LBP TNF
13
Show member pathways
12.24 IL10 IL22 IL6 TNF
14 12.21 IL10 IL6 LBP TNF
15
Show member pathways
12.17 CXCL8 IL6 LBP TNF
16 12.16 CXCL8 IL10 IL6 TNF
17
Show member pathways
12.13 ALB CCL2 F2 ICAM1 IL6 TNF
18
Show member pathways
11.98 CCL2 CXCL8 ICAM1 IL10 IL22 IL6
19 11.94 IL10 IL6 TNF
20 11.93 CCL2 ICAM1 IL6 TNF
21 11.91 CCL2 CXCL8 ICAM1 IL6 TNF
22 11.86 CXCL8 IL10 IL6 TNF
23 11.85 CXCL8 ICAM1 LBP TNF
24
Show member pathways
11.83 CXCL8 ICAM1 IL6 LBP
25 11.8 CXCL8 IL6 LBP
26 11.78 CXCL8 ICAM1 IL6
27 11.76 IL10 IL22 TNF
28 11.76 CCL2 CXCL8 ICAM1 IL6 TNF
29 11.72 IL10 IL6 TNF
30 11.69 CXCL8 IL10 IL6 TNF
31 11.61 CCL2 CXCL8 ICAM1 IL6 TNF
32 11.58 CXCL8 IL6 TNF
33 11.58 CCL2 CXCL8 IL6 TNF
34
Show member pathways
11.56 CXCL8 ICAM1 IL6 TNF
35 11.51 ICAM1 IL6 TNF
36 11.35 IL10 IL6 TNF
37 11.33 CCL2 CXCL8 IL6
38 11.32 CCL2 CXCL8 ICAM1 IL10 IL6 TNF
39 11.29 IL22 IL6 TNF
40 11.26 IL10 IL6 TNF
41 11.25 ICAM1 IL10 IL6 TNF
42 11.22 CCL2 CXCL8 ICAM1 IL10 IL6 LBP
43 11.16 CCL2 F2 ICAM1
44 11.12 CCL2 CXCL8 ICAM1 IL10 IL6 TNF
45 10.99 CXCL8 IL6 TNF
46 10.9 CCL2 ICAM1 TNF

GO Terms for Alcoholic Hepatitis

Cellular components related to Alcoholic Hepatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 ADAMTS13 ALB CCL2 CXCL8 F2 IL10
2 endoplasmic reticulum lumen GO:0005788 9.46 ADAMTS13 ALB F2 IL6
3 extracellular space GO:0005615 9.4 ADAMTS13 ALB CCL2 CXCL8 F2 GPT

Biological processes related to Alcoholic Hepatitis according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.97 CCL2 CXCL8 IL10 IL6 TNF
2 inflammatory response GO:0006954 9.85 CCL2 CXCL8 IL10 IL22 IL6 TNF
3 response to lipopolysaccharide GO:0032496 9.83 CXCL8 ICAM1 IL10 LBP
4 platelet activation GO:0030168 9.81 ADAMTS13 F2 IL6
5 positive regulation of DNA binding transcription factor activity GO:0051091 9.8 IL10 IL6 TNF
6 defense response to Gram-positive bacterium GO:0050830 9.8 IL6 LBP TNF
7 cellular response to tumor necrosis factor GO:0071356 9.78 ADAMTS13 CCL2 CXCL8 ICAM1
8 cellular response to interferon-gamma GO:0071346 9.77 ADAMTS13 CCL2 ICAM1
9 cellular response to interleukin-1 GO:0071347 9.77 CCL2 CXCL8 ICAM1
10 humoral immune response GO:0006959 9.71 CCL2 IL6 TNF
11 regulation of signaling receptor activity GO:0010469 9.7 CCL2 CXCL8 F2 IL10 IL22 IL6
12 positive regulation of interleukin-6 production GO:0032755 9.69 IL6 LBP TNF
13 embryonic digestive tract development GO:0048566 9.64 CXCL8 TNF
14 positive regulation of macrophage activation GO:0043032 9.63 IL10 LBP
15 lipopolysaccharide-mediated signaling pathway GO:0031663 9.63 CCL2 LBP TNF
16 response to molecule of bacterial origin GO:0002237 9.62 CXCL8 IL10
17 response to glucocorticoid GO:0051384 9.62 IL10 IL22 IL6 TNF
18 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.61 IL10 TNF
19 PERK-mediated unfolded protein response GO:0036499 9.61 CCL2 CXCL8
20 positive regulation of chemokine production GO:0032722 9.61 IL6 LBP TNF
21 negative regulation of lipid storage GO:0010888 9.58 IL6 TNF
22 endothelial cell apoptotic process GO:0072577 9.58 IL10 TNF
23 negative regulation of growth of symbiont in host GO:0044130 9.58 IL10 LBP TNF
24 negative regulation of cytokine secretion involved in immune response GO:0002740 9.56 IL10 TNF
25 acute-phase response GO:0006953 9.56 F2 IL22 IL6 LBP
26 cytokine-mediated signaling pathway GO:0019221 9.56 CCL2 CXCL8 ICAM1 IL10 IL22 IL6
27 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.55 ICAM1 TNF
28 receptor biosynthetic process GO:0032800 9.49 IL10 TNF
29 cellular response to lipopolysaccharide GO:0071222 9.23 ADAMTS13 CCL2 CXCL8 ICAM1 IL10 IL6

Molecular functions related to Alcoholic Hepatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 CCL2 CXCL8 IL10 IL22 IL6 TNF

Sources for Alcoholic Hepatitis

3 CDC
7 CNVD
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10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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31 HMDB
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62 PubMed
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69 SNOMED-CT via HPO
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74 UMLS via Orphanet
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