Alcoholic Liver Cirrhosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ALC009 MIFTS: 52	Alcoholic Liver Cirrhosis Categories: Endocrine diseases, Gastrointestinal diseases, Liver diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

Sources

Aliases & Classifications for Alcoholic Liver Cirrhosis

MalaCards integrated aliases for Alcoholic Liver Cirrhosis:

Name: Alcoholic Liver Cirrhosis ³⁹ ¹² ⁷⁷ ¹⁵ ¹⁷

Alcoholic Cirrhosis ¹² ⁵⁶ ¹⁵

Portal Cirrhosis ¹² ⁵⁶ ⁷⁴

Liver Cirrhosis, Alcoholic ⁴⁵ ⁷⁴

Laennec's Cirrhosis, Alcoholic ¹²

Alcoholic Cirrhosis of Liver ¹²

Laennec's Cirrhosis ¹²

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases Endocrine diseases Liver diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Diseases of the digestive system

Diseases of liver

Alcoholic liver disease

Alcoholic cirrhosis of liver

External Ids:

Disease Ontology ¹² DOID:14018

ICD9CM ³⁶ 571.2

MeSH ⁴⁵ D008104

NCIt ⁵¹ C34782

SNOMED-CT ⁶⁹ 75393009

ICD10 ³⁴ K70.3

EFO ¹⁷ EFO_1000802

UMLS ⁷⁴ C0023891 C1622502

Sources

Summaries for Alcoholic Liver Cirrhosis

MalaCards based summary : Alcoholic Liver Cirrhosis, also known as alcoholic cirrhosis, is related to peritonitis and esophageal varix, and has symptoms including icterus An important gene associated with Alcoholic Liver Cirrhosis is ADH1B (Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide), and among its related pathways/superpathways are Metabolism and Cytochrome P450 - arranged by substrate type. The drugs Angiotensin II and Losartan have been mentioned in the context of this disorder. Affiliated tissues include Liver, liver and bone, and related phenotype is liver/biliary system.

Wikipedia : ⁷⁷ Cirrhosis is a condition in which the liver does not function properly due to long-term damage. This... more...

Sources

Related Diseases for Alcoholic Liver Cirrhosis

Diseases related to Alcoholic Liver Cirrhosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 204)

#	Related Disease	Score	Top Affiliating Genes
1	peritonitis	30.6	ALB CXCL8 F2
2	esophageal varix	30.4	ALB F2
3	alcoholic neuropathy	30.3	ADH4 ALDH2
4	antipyrine metabolism	30.3	ALB F2
5	alcoholic pancreatitis	30.2	ADH1B ALDH2 CYP2E1
6	liver cirrhosis	30.1	ADH1B ADH1C ALB ALDH2 CYP2E1 F2
7	portal hypertension	30.1	ALB F2 GPT
8	schistosomiasis	30.1	ALB F2 GSTM1
9	hepatic coma	29.9	ALB F2 GPT
10	endocarditis	29.8	ALB CXCL8 F2
11	alcohol abuse	29.8	ALDH2 CYP2E1 GPT SLC17A5
12	hepatitis e	29.7	ALB F2 GPT
13	infantile liver failure syndrome 1	29.7	ALB F2 GPT SLC17A5
14	cholecystitis	29.7	ALB F2 GPT
15	hepatitis b	29.7	ALB F2 GPT SLC17A5
16	esophageal cancer	29.6	ADH1B ALB ALDH2 CXCL8 GSTM1
17	alcohol dependence	29.5	ADH1B ADH1C ADH4 ALDH2 CYP2E1
18	hepatic encephalopathy	29.5	ALB F2 GPT SLC17A5
19	viral hepatitis	29.4	ALB F2 GPT SLC17A5
20	alcoholic hepatitis	29.2	ALB CXCL8 CYP2E1 F2 GPT SLC17A5
21	fatty liver disease	29.2	CXCL8 CYP2E1 PNPLA3 SLC17A5
22	nonalcoholic steatohepatitis	28.8	CYP2E1 F2 GPT PNPLA3 SLC17A5
23	obstructive jaundice	28.6	ALB CXCL8 F2 GPT HGF SLC17A5
24	liver disease	28.4	ALB CYP2E1 F2 GPT HGF PNPLA3
25	hepatitis	10.4
26	non-a-e hepatitis	10.4	ALB F2
27	hepatocellular carcinoma	10.3
28	methanol poisoning	10.3	ADH1B ADH1C CYP2E1
29	fournier gangrene	10.3	ALB F2
30	sister chromatid exchange, frequency of	10.3	ALDH2 CYP2E1 GSTM1
31	abdominal tuberculosis	10.3	ALB F2
32	varicose veins	10.3
33	scabies	10.3	CXCL8 GSTM1
34	pyuria	10.3	ALB CXCL8
35	esophageal disease	10.3	ADH1B ALB ALDH2
36	pancreatitis	10.2
37	noma	10.2	ALB CXCL8
38	eccrine adenocarcinoma	10.2	AHSG F2
39	burns	10.2	ALB HGF
40	capillary leak syndrome	10.2	ALB CXCL8
41	hepatoportal sclerosis	10.2	F2 GPT
42	epstein-barr virus hepatitis	10.2	AHSG ALB F2
43	splenic disease	10.2	ALB F2
44	dengue hemorrhagic fever	10.2	ALB CXCL8 F2
45	hepatitis c virus	10.2
46	hepatitis c	10.2
47	inflammatory and toxic neuropathy	10.1	ADH4 ALDH2
48	extrinsic allergic alveolitis	10.1	ALB CXCL8 SOD2
49	calciphylaxis	10.1
50	tobacco addiction	10.1	ALDH2 CYP2A6 GSTM1

Comorbidity relations with Alcoholic Liver Cirrhosis via Phenotypic Disease Network (PDN): (show all 26)

Acquired Thrombocytopenia	Active Peptic Ulcer Disease
Acute Cystitis	Acute Kidney Failure
Acute Pancreatitis	Alcohol Abuse
Alcoholic Cardiomyopathy	Alcoholic Gastritis
Alcoholic Hepatitis	Alcoholic Neuropathy
Chronic Congestive Splenomegaly	Chronic Kidney Failure
Deficiency Anemia	Esophageal Varix
Familial Atrial Fibrillation	Fatty Liver Disease
Heart Disease	Hepatic Encephalopathy
Hepatocellular Carcinoma	Hepatorenal Syndrome
Hypersplenism	Iron Deficiency Anemia
Portal Hypertension	Protein-Energy Malnutrition
Respiratory Failure	Urea Cycle Disorder

Graphical network of the top 20 diseases related to Alcoholic Liver Cirrhosis:

Sources

Symptoms & Phenotypes for Alcoholic Liver Cirrhosis

UMLS symptoms related to Alcoholic Liver Cirrhosis:

icterus

MGI Mouse Phenotypes related to Alcoholic Liver Cirrhosis:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	liver/biliary system	MP:0005370	9.1	ALB ALDH2 CYP2E1 HGF PNPLA3 SOD2

Sources

Drugs & Therapeutics for Alcoholic Liver Cirrhosis

Drugs for Alcoholic Liver Cirrhosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 99)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Angiotensin II

Approved, Investigational

Phase 4

11128-99-7, 68521-88-0, 4474-91-3

172198

Losartan

Approved

Phase 4

114798-26-4

3961

Propranolol

Approved, Investigational

Phase 4,Not Applicable

525-66-6

4946

Spironolactone

Approved

Phase 4,Not Applicable

1952-01-7, 52-01-7

5833

Mannitol

Approved, Investigational

Phase 4

69-65-8

6251 453

Isoleucine

Approved, Investigational, Nutraceutical

Phase 4

73-32-5, 443-79-8

6306

Angiotensin Receptor Antagonists

Phase 4

Angiotensin II Type 1 Receptor Blockers

Phase 4

Anti-Arrhythmia Agents

Phase 4

Angiotensinogen

Phase 4

Liver Extracts

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Antihypertensive Agents

Phase 4

Giapreza

Phase 4

Hormones

Phase 4,Phase 2

Hormone Antagonists

Phase 4,Phase 2

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 4,Phase 2

valine

Phase 4

leucine

Phase 4

Mineralocorticoids

Phase 4

Adrenergic beta-Antagonists

Phase 4

Adrenergic Antagonists

Phase 4

Vasodilator Agents

Phase 4

Neurotransmitter Agents

Phase 4

Mineralocorticoid Receptor Antagonists

Phase 4

Natriuretic Agents

Phase 4

Adrenergic Agents

Phase 4

Diuretics, Potassium Sparing

Phase 4

diuretics

Phase 4

Baclofen

Approved

Phase 3

1134-47-0

2284

Ethanol

Approved

Phase 3,Not Applicable

64-17-5

702

Tacrolimus

Approved, Investigational

Phase 3

104987-11-3

6473866 445643 439492

Sirolimus

Approved, Investigational

Phase 3

53123-88-9

46835353 5284616 6436030

Miconazole

Approved, Investigational, Vet_approved

Phase 3

22916-47-8

4189

Everolimus

Approved

Phase 3

159351-69-6

70789204 6442177

Cobalt

Approved, Experimental

Phase 3

7440-48-4

104729

tannic acid

Approved

Phase 3,Not Applicable

1401-55-4

Benzocaine

Approved, Investigational

Phase 3,Not Applicable

1994-09-7, 94-09-7

2337

Iron

Approved, Experimental

Phase 3

7439-89-6, 15438-31-0

27284 23925

Anti-Infective Agents

Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Anti-Bacterial Agents

Phase 3,Phase 2,Early Phase 1

Immunosuppressive Agents

Phase 3

Immunologic Factors

Phase 3

Antibiotics, Antitubercular

Phase 3

Antifungal Agents

Phase 3

Calcineurin Inhibitors

Phase 3

Rifaximin

Approved, Investigational

Phase 2

80621-81-4

46783403 6436173

Prednisone

Approved, Vet_approved

Phase 2

53-03-2

5865

Caffeine

Approved

Phase 2

58-08-2

2519

Antineoplastic Agents, Hormonal

Phase 2

glucocorticoids

Phase 2

Interventional clinical trials:

(show all 39)

#	Name	Status	NCT ID	Phase	Drugs
1	Prevention of Decompensation in Liver Cirrhosis	Unknown status	NCT00239096	Phase 4	losartan (drug)
2	Sarcopenia Improves the Muscle Mass and Muscle Strength of Patients With Liver Cirrhosis-Child C	Recruiting	NCT03633279	Phase 4	Branched chain amino acid;Placebo
3	Hemodynamic Effects of Chronic Administration of Spironolactone and/or Propranolol in Alcoholic Cirrhotic Patients	Terminated	NCT00188045	Phase 4	Propranolol - Spironolactone
4	Baclofen in the Treatment of Alcohol Dependence With or Without Alcoholic Liver Disease	Completed	NCT01711125	Phase 3	Baclofen 30mg/day;Baclofen 75mg/day;Placebo
5	REnal Function in Liver Transplantation: Everolimus With Calcineurin Inhibitor (CNI)-Sparing sTrategy	Completed	NCT02115113	Phase 3	Everolimus;Tacrolimus
6	Proton Radiotherapy Versus Radiofrequency Ablation for Patients With Medium or Large Hepatocellular Carcinoma	Recruiting	NCT02640924	Phase 3
7	Phlebotomy and Risk of Hepatocellular Carcinoma in Patients With Compensated Alcoholic Cirrhosis	Terminated	NCT01342705	Phase 3
8	The Effectiveness and Safety for Mesenchymal Stem Cell for Alcoholic Liver Cirrhosis	Unknown status	NCT01741090	Phase 2
9	Effects of Rifaximin in Patients With Acute Alcoholic Hepatitis	Unknown status	NCT02116556	Phase 2	Prednisone;Rifaximin
10	REVIVE(Randomized Exploratory Clinical Trial to Evaluate the Safety and Effectiveness of Stem Cell Product in Alcoholic Liver Cirrhosis Patient)	Completed	NCT01875081	Phase 2
11	Dose Finding Study to Assess Safety and Efficacy of Stem Cells in Liver Cirrhosis	Completed	NCT01591200	Phase 2
12	A Phase II, Double-blinded, Randomized, Controlled Study to Evaluate the Efficacy and Safety of Vitalliver in Patients With Decompensated Cirrhosis	Completed	NCT00562783	Phase 2	Vitaliver;Placebo
13	Pharmacokinetics (PK) of Tipranavir/Ritonavir, Ribavirin, Pegylated Interferon (Peg INF) in Hepatitis C (HCV) Subjects With Mild Hepatic Impairment and in HCV, Hepatitis B (HBV), Hepatitis D Infected Subjects or Alcoholic Cirrhosis With Moderate Hepatic Impairment	Completed	NCT02259855	Phase 1	Tipranavir;Ritonavir;Pegylated interferon;Ribavirin
14	Study to Evaluate Hepatic Artery Injection of Autologous Human Bone Marrow-Derived MSCs in Patients With Alcoholic LC	Not yet recruiting	NCT03838250	Phase 1
15	Pangenomic Study During Alcoholic Cirrhosis	Unknown status	NCT01065233
16	Measurement of Fibrinogen in Patients With Systemic Inflammatory Response Syndrome (SIRS), Sepsis or Chronicle Liver Disease on Intensive Care Units (ICU)	Unknown status	NCT01169168
17	Prospective Analysis Of Cardiac Function In Cirrhotic Patients By Echocardiography And Its Correlation With Events	Unknown status	NCT01433848
18	FGL2/Fibroleukin and Hepatitis C Virus Recurrence Post Liver Transplantation	Unknown status	NCT00701272
19	Liver Transplantation Versus Alternative Therapies for Patients With Pugh B Alcoholic Cirrhosis	Completed	NCT00701792	Not Applicable
20	Adipose Tissue Involvement in Alcohol-induced Liver Inflammation in Human	Completed	NCT00388323	Not Applicable
21	Randomised Open-label Multicenter Study Evaluating Ciprofloxacin in Severe Alcoholic Hepatitis	Completed	NCT02326103	Early Phase 1	Ciprofloxacin;Placebo
22	Influence of Probiotics on Infections in Cirrhosis	Completed	NCT01607528	Not Applicable
23	Biomarkers for the Prognosis of Decompensated Alcoholic Liver Disease	Completed	NCT01701687
24	Acoustic Liver Biopsy in Normals and in Patients With Cirrhosis Using Endoscopic Ultrasound	Completed	NCT01208311
25	Indocyanine Green and Portal Pressure in Viral and Alcoholic Cirrhotic Patients With Hepatocarcinoma	Completed	NCT00827723
26	Subclinical Myocardial Dysfunction in Patients With Hepatic Cirrhosis	Completed	NCT01713478	Not Applicable
27	Value on Survival of Liver Volume After an Acute Decompensation of an Alcoholic Cirrhosis	Recruiting	NCT03508388
28	Comparison of Inflammatory Profiles and Regenerative Potential in Alcoholic Liver Disease	Recruiting	NCT03773887	Not Applicable
29	Safety and Performance Trial of DIALIVE Liver Dialysis Device in Acute On Chronic Liver Failure Patients	Recruiting	NCT03065699	Not Applicable
30	Mild Hypothermia and Acute Kidney Injury in Liver Transplantation	Recruiting	NCT03534141	Not Applicable
31	Comparison of ALD, NASH, and Healthy Control Patients	Recruiting	NCT03224949
32	Boramae Hospital Liver Cirrhosis Patient Cohort Study	Recruiting	NCT01943318
33	National Cohort of Uncomplicated Alcoholic Cirrhosis	Active, not recruiting	NCT01213927
34	Validation of the Procedure of Early Liver Transplantation in Alcoholic Hepatitis Resisting to Medical Treatment	Active, not recruiting	NCT01756794	Not Applicable
35	Zinc Supplementation in Alcoholic Cirrhosis	Active, not recruiting	NCT02072746	Not Applicable
36	Assessment of Nutritional Status of Patients With Liver Cirrhosis	Active, not recruiting	NCT03242798
37	Long-term Follow-up Study of Livercellgram in Alcoholic LC Patients Who Completed Livercellgram Phase 2 Study	Enrolling by invitation	NCT02806011
38	Prevalence of Exocrine Pancreatic Insufficiency in Patients With Decompensated Cirrhosis	Not yet recruiting	NCT03236038
39	Influence of ABO Blood Group on the Risk of Complications in Alcoholic or Viral C Cirrhosis?	Not yet recruiting	NCT03342170

Search NIH Clinical Center for Alcoholic Liver Cirrhosis

Cell-based therapeutics:

Data from LifeMap, the Embryonic Development and Stem Cells Database

Read about Alcoholic Liver Cirrhosis cell therapies at LifeMap Discovery.

Stem-cell-based therapeutic approaches for Alcoholic Liver Cirrhosis:

Livercellgram, bone marrow-derived mesenchymal stem cells for treatment of alcoholic liver cirrhosis

Embryonic/Adult Cultured Cells Related to Alcoholic Liver Cirrhosis:

Bone marrow-derived mesenchymal stem cells

Cochrane evidence based reviews: liver cirrhosis, alcoholic

Sources

Genetic Tests for Alcoholic Liver Cirrhosis

Sources

Anatomical Context for Alcoholic Liver Cirrhosis

MalaCards organs/tissues related to Alcoholic Liver Cirrhosis:

⁴²

Liver, Bone, Skin, T Cells, Testes, Monocytes, Neutrophil

Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Alcoholic Liver Cirrhosis:

#	Tissue Anatomical CompartmentCell	Relevance
1	Liver Liver Lobule Hepatocytes	Affected by disease

Sources

Publications for Alcoholic Liver Cirrhosis

Articles related to Alcoholic Liver Cirrhosis:

(show top 50) (show all 984)

#	Title	Authors	Year
1	Number of hospital contacts with alcohol problems predicts later risk of alcoholic liver cirrhosis. ( 29528775 )	Askgaard G...Leon DA	2019
2	Opportunities to Prevent Alcoholic Liver Cirrhosis in High-Risk Populations: A Systematic Review With Meta-Analysis. ( 30353053 )	Askgaard G...Tolstrup JS	2019
3	Value of gadoxetic acid-enhanced MRI and diffusion-weighted imaging in the differentiation of hypervascular hyperplastic nodule from small (<3 cm) hypervascular hepatocellular carcinoma in patients with alcoholic liver cirrhosis: A retrospective case-control study. ( 31062483 )	Kim SS...Heo NH	2019
4	Association Between Alcoholic Cirrhosis and Hemorrhagic Stroke: A Nationwide Population-based Study. ( 30957143 )	Lin SY...Kao CH	2019
5	Positive familial history for metabolic traits predisposes to early and more severe alcoholic cirrhosis: A cross-sectional study. ( 30188604 )	Bhadoria AS...Sarin SK	2019
6	A Rare Cause of Gastrointestinal Bleeding in a Patient With a History of Alcoholic Cirrhosis. ( 30240671 )	Zhai ZZ...Zuo XL	2019
7	Hip fracture risk in patients with alcoholic cirrhosis: Do comorbidities and complications matter? ( 30391026 )	Zhao LY...Liu HY	2019
8	Reply to: "Hip fracture risk in patients with alcoholic cirrhosis: Do comorbidities and complications matter?" ( 30424897 )	Otete H...West J	2019
9	A two gene-based risk score predicts alcoholic cirrhosis development in males with at-risk alcohol consumption. ( 30666147 )	Mancina RM...Corradini SG	2019
10	Charges for Alcoholic Cirrhosis Exceed All Other Etiologies of Cirrhosis Combined: A National and State Inpatient Survey Analysis. ( 30673984 )	Barritt AS...Bataller R	2019
11	Transudative chylothorax associated with alcoholic cirrhosis. ( 30949356 )	Koshima Y...Ikeda T	2019
12	Increased serum malondialdehyde levels are associated with grey matter volume loss in patients with non-alcoholic cirrhosis. ( 30976547 )	Zheng W...Wang W	2019
13	Cost of illness of non-alcoholic liver cirrhosis in Japan: A time trend analysis and future projections. ( 28497644 )	Kitazawa T...Hasegawa T	2018
14	Diagnostic specificity and sensitivity of PIVKAII, GP3, CSTB, SCCA1 and HGF for the diagnosis of hepatocellular carcinoma in patients with alcoholic liver cirrhosis. ( 28766361 )	Uni? A...Grgurevi? I	2018
15	Reduced platelet activation and platelet aggregation in patients with alcoholic liver cirrhosis. ( 28895774 )	Vinholt PJ...Nybo M	2018
16	A study of serological markers and lipid profile in non-alcoholic liver cirrhosis patients. ( 29348089 )	Khan S...Jamal S	2018
17	The Impact of Outpatient Clinical Care on the Survival and Hospitalisation Rate in Patients with Alcoholic Liver Cirrhosis. ( 29520208 )	Majc D...Tepes B	2018
18	Successful Distal Gastrectomy for Gastric Cancer with Child-Pugh Class B Alcoholic Liver Cirrhosis. ( 29715144 )	Iwabu J...Hanazaki K	2018
19	Gallbladder perforation in a patient with alcoholic liver cirrhosis and asymptomatic gallstones: A case report. ( 29718836 )	Shi X...Wang G	2018
20	Circulating Endothelial Progenitor Cells Present an Inflammatory Phenotype and Function in Patients With Alcoholic Liver Cirrhosis. ( 29872403 )	Kaur S...Seth D	2018
21	VALIDATION OF CLIF-C-ACLF SCORE FOR ALCOHOLIC LIVER CIRRHOSIS. ( 29905553 )	Slyvka N...Abdelrahman F	2018
22	Vitamin D supplementation in patients with alcoholic liver cirrhosis: a prospective study. ( 29963831 )	Savi? ?...Abenavoli L	2018
23	An adult patient with alcoholic liver cirrhosis and IgA vasculitis. ( 30024712 )	Barrios L...Robaeys G	2018
24	A proteomic approach of biomarker candidate discovery for alcoholic liver cirrhosis. ( 30034555 )	Nallagangula KS...Shashidhar KN	2018
25	Plasmapheresis for Spur Cell Anemia in a Patient with Alcoholic Liver Cirrhosis. ( 30034891 )	Miki K...Imashuku S	2018
26	Validation of modified fibrosis-4 index for predicting hepatocellular carcinoma in patients with compensated alcoholic liver cirrhosis. ( 30508959 )	Kim JH...Choi DH	2018
27	Need for surveillance of hepatocellular carcinoma in patients with alcoholic cirrhosis. ( 30318321 )	D'Amico G...Bataller R	2018
28	Oxidative stress, NOx/l-arginine ratio and glutathione/glutathione S-transferase ratio as predictors of 'sterile inflammation' in patients with alcoholic cirrhosis and hepatorenal syndrome type II. ( 29658815 )	Nickovic VP...Kocic G	2018
29	Bilateral optic neuropathy related to severe anemia in a patient with alcoholic cirrhosis: a case report and review of the literature. ( 29065678 )	Humbertjean-Selton L...Richard S	2018
30	Safety and efficacy of biological therapies in patients with psoriasis with alcoholic cirrhosis: a French retrospective study of 23 cases. ( 29480522 )	Begon E...Groupe d'Etudes Multicentrique GEM RESOPSO	2018
31	Targeting toll-like receptor 7/8 improves host anti-infective response in alcoholic cirrhosis. ( 28687679 )	Albano E...Stickel F	2018
32	Ethyl Glucuronide in Hair Is an Accurate Biomarker of Chronic Excessive Alcohol Use in Patients With Alcoholic Cirrhosis. ( 28830836 )	Verbeek J...Nevens F	2018
33	Alcohol Relapse After Liver Transplantation for Alcoholic Cirrhosis-Impact on Liver Graft and Patient Survival: A Meta-analysis. ( 29194512 )	Kodali S...Singal AK	2018
34	Evaluation of laboratory tests for cirrhosis and for alcohol use, in the context of alcoholic cirrhosis. ( 29277282 )	Whitfield JB...GenomALC Consortium	2018
35	The high burden of alcoholic cirrhosis in privately insured persons in the United States. ( 29579356 )	Mellinger JL...Lok ASF	2018
36	Primary medullary hemorrhage in a patient with coagulopathy due to alcoholic cirrhosis: A case report. ( 29620649 )	Shen G...Nan G	2018
37	Hip fracture risk in patients with alcoholic cirrhosis: A population-based study using English and Danish data. ( 29673756 )	Otete H...West J	2018
38	A case of colonic varices complicated by alcoholic cirrhosis treated using balloon-occluded retrograde transvenous obliteration. ( 29696582 )	Matsumoto K...Mochida S	2018
39	Predictive value of liver and spleen stiffness in advanced alcoholic cirrhosis with refractory ascites. ( 29890557 )	Lindner F...Karlas T	2018
40	Quantification and isotopic analysis of bulk and of exchangeable and ultrafiltrable serum copper in healthy and alcoholic cirrhosis subjects. ( 30086927 )	Lauwens S...Vanhaecke F	2018
41	Estimate of hepatocellular carcinoma incidence in patients with alcoholic cirrhosis. ( 30092234 )	Ganne-Carri? N...for CIRRAL Group	2018
42	Levels of circulating follicular helper T cells, T helper 1 cells, and the prognostic significance of soluble form of CD40 ligand on survival in patients with alcoholic cirrhosis. ( 30221017 )	Hollister K...Liangpunsakul S	2018
43	Colder Weather and Fewer Sunlight Hours Increase Alcohol Consumption and Alcoholic Cirrhosis Worldwide. ( 30324707 )	Ventura-Cots M...Bataller R	2018
44	RIPK3-Mediated Necroptosis and Neutrophil Infiltration Are Associated with Poor Prognosis in Patients with Alcoholic Cirrhosis. ( 30596105 )	Zhang Z...Wang Y	2018
45	Risk for alcoholic liver cirrhosis after an initial hospital contact with alcohol problems: A nationwide prospective cohort study. ( 27862159 )	Askgaard G...Tolstrup JS	2017
46	Data on gut metagenomes of the patients with alcoholic dependence syndrome and alcoholic liver cirrhosis. ( 28138508 )	Tyakht AV...Govorun VM	2017
47	Disialo-Trisialo Bridging Phenomenon of Transferrin Isoform Detected by Capillary Electrophoresis in Patient with Alcoholic Liver Cirrhosis: First Case Report from Asia. ( 28271694 )	Yang HS...Cho SY	2017
48	Association between Serum Selenium Concentrations and Levels of Proinflammatory and Profibrotic Cytokines-Interleukin-6 and Growth Differentiation Factor-15, in Patients with Alcoholic Liver Cirrhosis. ( 28430124 )	Prystupa A...Za?uska W	2017
49	A tip from the nose: rhinocerebral mucormycosis in a patient with alcoholic liver cirrhosis and cocaine abuse, an uncommon association. ( 28784893 )	Avelar Rodriguez D...Miranda Ackerman RC	2017
50	Bacteremia Caused by Campylobacter Fetus in a Patient With Hepatitis B Virus Infection Complicated with Alcoholic Liver Cirrhosis. ( 28879715 )	Chen Y...Wu Z	2017

Sources

Genes for Alcoholic Liver Cirrhosis

Genes related to Alcoholic Liver Cirrhosis (0 elite genes):

(show all 16)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	ADH1B	Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide	Protein Coding	32.31	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	15220553 8845660 11748356 (more) 11966948 7557863
2	ADH1C	Alcohol Dehydrogenase 1C (Class I), Gamma Polypeptide	Protein Coding	31.66	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	1592339 15220553 11748356 (more) 11966948
3	CYP2E1	Cytochrome P450 Family 2 Subfamily E Member 1	Protein Coding	31.16	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	19428381 11748356 20171022 (more) 9660317 14720455 11966948 15220553 19157724 11796198
4	ALDH2	Aldehyde Dehydrogenase 2 Family Member	Protein Coding	31.08	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	12824748 15220553 8845660 (more) 11748356 11966948
5	ALB	Albumin	Protein Coding	31.06	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	2123913 7678368 8114309 (more) 7927222 11755315 9608061 9253235
6	F2	Coagulation Factor II, Thrombin	Protein Coding	30.76	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	16123951 8667440 9608061 (more) 9253235
7	GSTM1	Glutathione S-Transferase Mu 1	Protein Coding	26.39	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	19157724 20171022 19428381 (more) 8834254 11966948
8	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	25.4	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	11282449 8738722 15220553 (more) 9875144 11059648 10418175 8325620 17036498
9	GPT	Glutamic--Pyruvic Transaminase	Protein Coding	25.14	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶	10204356 11985059
10	AHSG	Alpha 2-HS Glycoprotein	Protein Coding	25.05	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	17394649 11943951
11	SOD2	Superoxide Dismutase 2	Protein Coding	24.19	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	19731237 15765450 19157724 (more) 2254630
12	HGF	Hepatocyte Growth Factor	Protein Coding	23.89	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	16784653
13	CYP2A6	Cytochrome P450 Family 2 Subfamily A Member 6	Protein Coding	23.84	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	11131450
14	SLC17A5	Solute Carrier Family 17 Member 5	Protein Coding	23.32	Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	9049444 1916663
15	ADH4	Alcohol Dehydrogenase 4 (Class II), Pi Polypeptide	Protein Coding	23.17	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
16	PNPLA3	Patatin Like Phospholipase Domain Containing 3	Protein Coding	22.65	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

Sources

Variations for Alcoholic Liver Cirrhosis

Sources

Expression for Alcoholic Liver Cirrhosis

Search GEO for disease gene expression data for Alcoholic Liver Cirrhosis.

Sources

Pathways for Alcoholic Liver Cirrhosis

Pathways related to Alcoholic Liver Cirrhosis according to GeneCards Suite gene sharing:

(show all 16)

#	Super pathways	Score	Top Affiliating Genes
1	Metabolism ⁶⁷ Show member pathways Metabolic pathways ³⁸ Metabolism of lipids and lipoproteins ⁶⁷	13.87	ADH1B ADH1C ADH4 ALB ALDH2 CYP2A6
2	Cytochrome P450 - arranged by substrate type ⁶⁷ Show member pathways Amine Oxidase reactions ⁶⁷ Aryl hydrocarbon receptor signalling ⁶⁷ Benzo(a)pyrene metabolism ¹ Biological oxidations ⁶⁷ bupropion degradation ¹ CYP2E1 reactions ⁶⁷ Cytosolic sulfonation of small molecules ⁶⁷ Eicosanoids ⁶⁷ Endogenous sterols ⁶⁷ Estradiol metabolism ²³ Ethanol oxidation ⁶⁷ Fatty Acid Omega Oxidation ¹ Fatty acids ⁶⁷ Metapathway biotransformation ¹ Methylation ⁶⁷ Miscellaneous substrates ⁶⁷ Oxidation by Cytochrome P450 ¹ Phase 1 - Functionalization of compounds ⁶⁷ Phase II conjugation ⁶⁷ Sterols are 12-hydroxylated by CYP8B1 ⁶⁷ Transport and synthesis of PAPS ⁶⁷ Vitamin D2 (ergocalciferol) metabolism ²³ vitamin D3 biosynthesis ¹ Vitamins ⁶⁷ Xenobiotics ⁶⁷	12.98	ADH1B ADH1C ADH4 ALDH2 CYP2A6 CYP2E1
3	Glucose metabolism ⁶⁷ Show member pathways gluconeogenesis ¹ Gluconeogenesis ⁶⁷ glycogen biosynthesis ¹ Glycogen breakdown (glycogenolysis) ⁶⁷ Glycogen storage disease type 0 (liver GYS2) ⁶⁷ Glycogen storage disease type II (GAA) ⁶⁷ Glycogen storage disease type IV (GBE1) ⁶⁷ Glycogen synthesis ⁶⁷ glycolysis ¹ Glycolysis ⁶⁷ Glycolysis / Gluconeogenesis ³⁸ Glycolysis and Gluconeogenesis ¹ Glycolysis and gluconeogenesis (short map) ²³ Lysosomal glycogen catabolism ⁶⁷ malate-aspartate shuttle ¹	12.43	ADH1B ADH1C ADH4 ALDH2
4	Drug metabolism - cytochrome P450 ³⁸ Show member pathways Aflatoxin B1 metabolism ¹ Artemisinin and Derivatives Pathway, Pharmacokinetics ⁶² Arylamine metabolism ¹ Benzo[a]pyrene metabolism ²³ Benzodiazepine Pathway, Pharmacokinetics ⁶² Celecoxib Pathway, Pharmacokinetics ⁶² Chemical carcinogenesis ³⁸ Drug metabolism - other enzymes ³⁸ Fluvoxamine Pathway, Pharmacokinetics ⁶² Haloperidol Pathway, Pharmacokinetics ⁶² Ifosfamide Pathway, Pharmacokinetics ⁶² Metabolism of xenobiotics by cytochrome P450 ³⁸ Naproxen Pathway, Pharmacokinetics ⁶² Nicotine Metabolism ¹ Nicotine Pathway, Pharmacokinetics ⁶² Oxycodone Pathway, Pharmacokinetics ⁶² Retinol metabolism ²³ Retinol metabolism ³⁸ Sertraline Pathway, Pharmacokinetics ⁶² Voriconazole Pathway, Pharmacokinetics ⁶²	12.23	ADH1B ADH1C ADH4 ALDH2 CYP2A6 CYP2E1
5	NRF2 pathway ¹	11.9	CYP2A6 GSTM1 HGF
6	superpathway of tryptophan utilization ¹ Show member pathways melatonin degradation I ¹ NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde ¹ NAD Biosynthesis II (from tryptophan) ¹ NAD de novo biosynthesis ¹ serotonin degradation ¹ superpathway of melatonin degradation ¹ tryptophan degradation via tryptamine ¹	11.69	ADH1B ALDH2 CYP2A6 CYP2E1
7	Fatty acid metabolism ³⁸ Show member pathways Fatty acid degradation ³⁸	11.66	ADH1B ADH1C ADH4 ALDH2
8	Acetaminophen Pathway (therapeutic doses), Pharmacokinetics ⁶² Show member pathways 2-Naphthylamine and 2-Nitronaphtalene metabolism ²³ Acetaminophen metabolism ²³ Acetaminophen Pathway (toxic doses), Pharmacokinetics ⁶²	11.57	CYP2A6 CYP2E1 GSTM1
9	Naphthalene metabolism ²³	10.96	CYP2A6 CYP2E1 GSTM1
10	Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics ⁶²	10.84	CYP2A6 CYP2E1
11	ethanol degradation II ¹ Show member pathways acetate conversion to acetyl-CoA ¹ ethanol degradation IV ¹ oxidative ethanol degradation III ¹	10.67	ADH1B ALDH2 CYP2E1
12	Abacavir Pathway, Pharmacokinetics/Pharmacodynamics ⁶² Show member pathways adenine and adenosine salvage II ¹	10.66	ADH1B ADH1C
13	noradrenaline and adrenaline degradation ¹ Show member pathways Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB ⁶⁷ dopamine degradation ¹	10.58	ADH1B ADH4 ALDH2
14	Cyclophosphamide Pathway, Pharmacodynamics ⁶² Show member pathways Ifosfamide Pathway, Pharmacodynamics ⁶²	10.42	ADH1B ADH1C ADH4 ALDH2
15	acetone degradation I (to methylglyoxal) ¹ Show member pathways methylglyoxal degradation III ¹	10.37	ADH1B CYP2A6 CYP2E1
16	Benzene metabolism ¹	10.26	CYP2E1 GSTM1

Sources

GO Terms for Alcoholic Liver Cirrhosis

Cellular components related to Alcoholic Liver Cirrhosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	blood microparticle	GO:0072562	9.13	AHSG ALB F2
2	platelet alpha granule lumen	GO:0031093	8.8	AHSG ALB HGF

Biological processes related to Alcoholic Liver Cirrhosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	oxidation-reduction process	GO:0055114	9.5	ADH1B ADH1C ADH4 ALDH2 CYP2A6 CYP2E1
2	drug metabolic process	GO:0017144	9.43	CYP2A6 CYP2E1
3	platelet degranulation	GO:0002576	9.43	AHSG ALB HGF
4	exogenous drug catabolic process	GO:0042738	9.4	CYP2A6 CYP2E1
5	organic acid metabolic process	GO:0006082	9.37	CYP2A6 CYP2E1
6	epoxygenase P450 pathway	GO:0019373	9.32	CYP2A6 CYP2E1
7	alcohol metabolic process	GO:0006066	9.16	ADH4 ALDH2
8	ethanol oxidation	GO:0006069	8.92	ADH1B ADH1C ADH4 ALDH2

Molecular functions related to Alcoholic Liver Cirrhosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	oxidoreductase activity	GO:0016491	9.5	ADH1B ADH1C ADH4 ALDH2 CYP2A6 CYP2E1
2	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	GO:0016620	9.37	ADH4 ALDH2
3	retinol dehydrogenase activity	GO:0004745	9.32	ADH1C ADH4
4	arachidonic acid epoxygenase activity	GO:0008392	9.26	CYP2A6 CYP2E1
5	alcohol dehydrogenase (NAD) activity	GO:0004022	9.16	ADH1C ADH4
6	alcohol dehydrogenase activity, zinc-dependent	GO:0004024	8.8	ADH1B ADH1C ADH4

Sources

Sources for Alcoholic Liver Cirrhosis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia