MCID: ALC009
MIFTS: 57

Alcoholic Liver Cirrhosis

Categories: Gastrointestinal diseases, Liver diseases
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Aliases & Classifications for Alcoholic Liver Cirrhosis

MalaCards integrated aliases for Alcoholic Liver Cirrhosis:

Name: Alcoholic Liver Cirrhosis 11 75 14 36 16 33
Alcoholic Cirrhosis 11 53 14 33
Portal Cirrhosis 11 53 71
Alcoholic Cirrhosis of Liver 11 31
Liver Cirrhosis, Alcoholic 43 71
Laennec's Cirrhosis, Alcoholic 11
Alcoholic Laennec Cirrhosis 33
Alcohol Hepatic Cirrhosis 33
Alcoholic Cirrhosis Nos 33
Alcohol Liver Cirrhosis 33
Laennec's Cirrhosis 11
Alcohol Cirrhosis 33
Laennec Cirrhosis 33
Etoh Cirrhosis 33

Classifications:



External Ids:

Disease Ontology 11 DOID:14018
ICD9CM 34 571.2
MeSH 43 D008104
NCIt 49 C34782
SNOMED-CT 68 420054005
ICD10 31 K70.3
ICD11 33 474954105
UMLS 71 C0023891 C1622502

Summaries for Alcoholic Liver Cirrhosis

MalaCards based summary: Alcoholic Liver Cirrhosis, also known as alcoholic cirrhosis, is related to alcohol dependence and varicose veins, and has symptoms including icterus An important gene associated with Alcoholic Liver Cirrhosis is CYP2E1 (Cytochrome P450 Family 2 Subfamily E Member 1), and among its related pathways/superpathways are Metabolism and Metapathway biotransformation Phase I and II. The drugs Angiotensin II and Losartan have been mentioned in the context of this disorder. Affiliated tissues include Liver, bone marrow and skin, and related phenotypes are no effect and no effect

Wikipedia: 75 Cirrhosis, also known as liver cirrhosis or hepatic cirrhosis, and end-stage liver disease, is the... more...

Related Diseases for Alcoholic Liver Cirrhosis

Diseases related to Alcoholic Liver Cirrhosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 973)
# Related Disease Score Top Affiliating Genes
1 alcohol dependence 31.4 TNF INS IL1B GPT CYP2E1 ALDH2
2 varicose veins 31.3 TNF IL6 F2 CXCL8
3 liver cirrhosis 31.0 TNF INS IL6 GPT F2 CYP2E1
4 portal hypertension 30.9 TNF GPT F2 ALB AFP
5 hepatic encephalopathy 30.9 TNF IL6 GPT F2 ALB
6 esophageal varix 30.8 INS GPT F2 ALB AFP
7 alcoholic pancreatitis 30.8 GSTM1 CYP2E1 ALDH2 ADH1C ADH1B
8 peritonitis 30.7 TNF IL6 IL1B F2 CXCL8 ALB
9 hepatorenal syndrome 30.7 GPT F2 ALB AFP
10 alcoholic cardiomyopathy 30.7 CYP2E1 ALDH2 ADH1B
11 allergic disease 30.7 TNF IL6 IL1B CXCL8
12 vasculitis 30.7 TNF IL6 IL1B CXCL8
13 toxic shock syndrome 30.7 TNF IL6 IL1B CXCL8
14 gastritis 30.7 TNF IL6 IL1B CXCL8
15 henoch-schoenlein purpura 30.6 TNF IL6 ALB
16 purpura 30.6 TNF IL6 IL1B F2 CXCL8
17 nutritional deficiency disease 30.6 IL6 F2 ALB
18 alcoholic neuropathy 30.6 TNF IL1B ALDH2
19 mucormycosis 30.6 TNF INS IL6
20 viral infectious disease 30.5 TNF IL6 IL1B GPT CXCL8
21 fasciitis 30.5 TNF IL6 CXCL8
22 vitamin k deficiency bleeding 30.5 F2 AHSG AFP
23 fatty liver disease 30.5 TNF INS IL6 IL1B GPT CYP2E1
24 crohn's colitis 30.5 TNF IL6 IL1B
25 viral hepatitis 30.5 IL6 GPT F2 ALB AFP
26 meningitis 30.4 TNF IL6 IL1B CXCL8 ALB
27 splenic tuberculosis 30.4 TNF F2 ALB
28 inflammatory bowel disease 1 30.4 TNF IL6 IL1B
29 poliomyelitis 30.4 TNF IL6 ALB
30 back pain 30.4 IL6 IL1B CXCL8
31 acute kidney failure 30.4 IL6 GPT F2 ALB
32 liver disease 30.4 TNF INS IL6 GPT F2 CYP2E1
33 periodontitis 30.3 TNF IL6 IL1B CXCL8
34 hepatocellular adenoma 30.3 GSTP1 GSTM1 AFP
35 tobacco addiction 30.3 GSTP1 GSTM1 CYP2E1 ALDH2 ADH1B
36 angina pectoris 30.3 TNF INS IL6
37 cholecystitis 30.3 GPT F2 ALB
38 amyloidosis 30.3 TNF INS IL6 IL1B ALB
39 pericarditis 30.3 TNF IL6 IL1B CXCL8
40 choledocholithiasis 30.3 GPT F2 ALB
41 budd-chiari syndrome 30.3 GPT F2 ALB AFP
42 duodenal ulcer 30.3 TNF INS IL6 IL1B CXCL8
43 alcoholic hepatitis 30.3 TNF IL6 IL1B GPT F2 CYP2E1
44 hypersensitivity vasculitis 30.3 TNF IL6 F2 ALB
45 aspergillosis 30.3 TNF IL6 IL1B CXCL8
46 spondylitis 30.3 TNF IL6 IL1B
47 adult syndrome 30.3 TNF INS IL6 GAPDH
48 rubella 30.3 TNF IL6 IL1B GPT
49 nephrotic syndrome 30.3 TNF INS IL6 IL1B F2 ALB
50 infective endocarditis 30.3 IL6 F2 CXCL8 ALB

Comorbidity relations with Alcoholic Liver Cirrhosis via Phenotypic Disease Network (PDN): (show all 26)


Acquired Thrombocytopenia Active Peptic Ulcer Disease
Acute Cystitis Acute Kidney Failure
Acute Pancreatitis Alcohol Use Disorder
Alcoholic Cardiomyopathy Alcoholic Gastritis
Alcoholic Hepatitis Alcoholic Neuropathy
Chronic Congestive Splenomegaly Chronic Kidney Disease
Deficiency Anemia Esophageal Varix
Familial Atrial Fibrillation Fatty Liver Disease
Heart Disease Hepatic Encephalopathy
Hepatocellular Carcinoma Hepatorenal Syndrome
Hypersplenism Iron Deficiency Anemia
Portal Hypertension Protein-Energy Malnutrition
Respiratory Failure Urea Cycle Disorder

Graphical network of the top 20 diseases related to Alcoholic Liver Cirrhosis:



Diseases related to Alcoholic Liver Cirrhosis

Symptoms & Phenotypes for Alcoholic Liver Cirrhosis

UMLS symptoms related to Alcoholic Liver Cirrhosis:


icterus

GenomeRNAi Phenotypes related to Alcoholic Liver Cirrhosis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.17 ADH1B ADH1C AFP AHSG AKR1A1 ALB
2 no effect GR00402-S-2 10.17 ADH1B ADH1C AHSG ALB ALDH2 CYP2E1

MGI Mouse Phenotypes related to Alcoholic Liver Cirrhosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.09 ADH1B ADH1C AFP AHSG AKR1A1 ALB
2 neoplasm MP:0002006 10.02 AFP ALB ALDH2 CYP2E1 GSTP1 IL1B
3 liver/biliary system MP:0005370 9.96 AFP ALB ALDH2 CYP2E1 GAPDH IL6
4 muscle MP:0005369 9.92 AHSG ALB ALDH2 F2 IL6 INS
5 growth/size/body region MP:0005378 9.83 ADH1B ADH1C AHSG AKR1A1 ALDH2 CYP2E1
6 skeleton MP:0005390 9.32 AHSG AKR1A1 ALDH2 CYP2E1 F2 GPT

Drugs & Therapeutics for Alcoholic Liver Cirrhosis

Drugs for Alcoholic Liver Cirrhosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 72)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198
2
Losartan Approved Phase 4 114798-26-4 3961
3
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
4
Propranolol Approved, Investigational Phase 4 318-98-9, 525-66-6 62882 4946
5
Angiotensinogen Phase 4 16133225
6 Angiotensin Receptor Antagonists Phase 4
7 Angiotensin II Type 1 Receptor Blockers Phase 4
8 Giapreza Phase 4
9 Antihypertensive Agents Phase 4
10 Anti-Arrhythmia Agents Phase 4
11 Adrenergic Antagonists Phase 4
12 Adrenergic Agents Phase 4
13 Hormones Phase 4
14 Hormone Antagonists Phase 4
15 Mineralocorticoids Phase 4
16 Mineralocorticoid Receptor Antagonists Phase 4
17 Vasodilator Agents Phase 4
18 Neurotransmitter Agents Phase 4
19 Adrenergic beta-Antagonists Phase 4
20 Diuretics, Potassium Sparing Phase 4
21 diuretics Phase 4
22
Benzocaine Approved, Investigational Phase 3 1994-09-7, 94-09-7 2337
23
Iron Approved Phase 3 7439-89-6 29936
24
Tannic acid Approved Phase 3 1401-55-4 16129878 16129778
25
Caffeine Approved Phase 2 58-08-2 2519
26
Ethanol Approved Phase 1, Phase 2 64-17-5 702
27
Baclofen Approved Phase 1, Phase 2 1134-47-0 2284
28 Liver Extracts Phase 1, Phase 2
29 GABA Agonists Phase 1, Phase 2
30
Ritonavir Approved, Investigational Phase 1 155213-67-5 392622
31
Ribavirin Approved Phase 1 36791-04-5 37542
32
Peginterferon alfa-2a Approved, Investigational Phase 1 198153-51-4
33
Tipranavir Approved, Investigational Phase 1 174484-41-4 65027 54682461
34 Anti-Infective Agents Phase 1
35 Cytochrome P-450 Enzyme Inhibitors Phase 1
36 Cytochrome P-450 CYP3A Inhibitors Phase 1
37 interferons Phase 1
38 Interferon-alpha Phase 1
39 Interferon alpha-2 Phase 1
40 Anti-HIV Agents Phase 1
41 Antiviral Agents Phase 1
42 Iron-Dextran Complex Phase 1
43
protease inhibitors Phase 1
44 Antimetabolites Phase 1
45 Anti-Retroviral Agents Phase 1
46 HIV Protease Inhibitors Phase 1
47
Zinc sulfate Approved, Investigational 7733-02-0
48
Zinc cation Approved, Experimental, Investigational 7440-66-6, 23713-49-7 32051
49
Furosemide Approved, Vet_approved 54-31-9 3440
50
Lactulose Approved 4618-18-2 11333

Interventional clinical trials:

(show all 32)
# Name Status NCT ID Phase Drugs
1 Losartan in the Prevention of Sodium Retention and Ascites in Liver Cirrhosis - a Prospective Randomized Long-Term Study Unknown status NCT00239096 Phase 4 losartan (drug)
2 Hemodynamic Effects of Chronic Administration of Spironolactone, Propranolol and Their Association in Alcoholic Cirrhotic Patients Terminated NCT00188045 Phase 4 Propranolol - Spironolactone
3 A Multicenter, Randomized, Open-label Phase III Clinical Trial to Evaluate Efficacy and Safety of the Cellgram-LC in Patients With Alcoholic Liver Cirrhosis Recruiting NCT04689152 Phase 3
4 Influence of Iron Depletion by Phlebotomy on the Risk of Hepatocellular Carcinoma Occurrence in Patients With Compensated Alcoholic Cirrhosis. Prospective, Multicentre, Randomized Trial Terminated NCT01342705 Phase 3
5 The Evaluation of Effectiveness and Safety for New Therapy With Bone Marrow Derived Autologous Mesenchymal Stem Cell for Hepatic Failure Caused by Alcoholic Liver Cirrhosis Unknown status NCT01741090 Phase 2
6 Randomized Exploratory Clinical Trial to Evaluate the Safety and Effectiveness of Stem Cell Product in Alcoholic Liver Cirrhosis Patient. Completed NCT01875081 Phase 2
7 A Parallel Group Randomized Open Blinded End Point Evaluation, Multicentric, Dose Escalation, Phase -II Study Assessing the Safety and Efficacy of Intraarterial (Hepatic) Ex-vivo Cultured Adult Allogenic Mesenchymal Stem Cells in Patients With Alcoholic Liver Cirrhosis Completed NCT01591200 Phase 2
8 Maintaining Alcohol Abstinence in Alcoholic Patients With Liver Cirrhosis: Efficacy and Safety of Baclofen Administration in a Randomized Double Blind Controlled Study Completed NCT00525252 Phase 1, Phase 2 Baclofen;placebo
9 A Phase I, Open-Label, Single-Dose Study to Evaluate the Safety and Efficacy of Hepatic Artery Injection of Autologous Human Bone Marrow-Derived Mesenchymal Stem Cells (Cellgram™) in Patients With Alcoholic Liver Cirrhosis Unknown status NCT03838250 Phase 1
10 Open Label, Study to Determine the Pharmacokinetic Interactions of Steady State Tipranavir/Ritonavir (500/200 mg) and Steady State Ribavirin and Pegylated Interferon Alfa 2a in HIV Negative, HCV Infected Subjects With Mild Hepatic Impairment and the Pharmacokinetic Properties of Tipranavir/Ritonavir in HIV Negative, HCV, HBV, Hepatitis Delta Infected Subjects or Alcoholic Cirrhosis Subjects With Moderate Hepatic Impairment Completed NCT02259855 Phase 1 Tipranavir;Ritonavir;Pegylated interferon;Ribavirin
11 A Pilot Clinical Study to Evaluate Safety, Tolerability and Preliminary Efficacy of Intravenous Infusion of Umbilical Cord Mesenchymal Stem Cell in the Treatment of Decompensated Alcoholic Cirrhosis Recruiting NCT05155657 Phase 1
12 CIRRAL: Hepatocellular Carcinoma in Patients With Uncomplicated Alcoholic Cirrhosis: Incidence and Predictive Factors. A Multicentric Prospective Cohort Unknown status NCT01213927
13 Prognostic Value of Liver Volume on Acute Decompensation of Alcoholic Cirrhosis, a Prospective Multicenter Observational Study Unknown status NCT03508388
14 Phenotypical and Pathophysiological Characterization of Patients With Alcohol-related Liver Disease Unknown status NCT04363424
15 Long-term Follow-up Study of Livercellgram in Alcoholic Liver Cirrhosis Patients Who Completed Livercellgram Phase 2 Study Completed NCT02806011
16 A Double-Blind, Randomized, Placebo-Controlled Study of the Effects of Daily Oral Zinc Sulfate (220 mg) in Subjects With Alcoholic Cirrhosis Completed NCT02072746
17 Randomized Trial Comparing Liver Transplantation to Alternative Therapies for Patients With Pugh B Alcoholic Cirrhosis Completed NCT00701792
18 Genetical Predisposition in Hepatocellular Carcinoma : Pangenomic Link Study During Alcoholic Cirrhosis Completed NCT01065233
19 Makuuchi Versus Barcelona Clinic of Liver Cancer Criteria in Cirrhotic Patients With Hepatocellular Carcinoma. Does Etiology of Cirrhosis Influence the Relationship Between the Portal Pressure and Quantitative Tests of Liver Function? Completed NCT00827723
20 Adipose Tissue Involvement in Alcohol-induced Liver Inflammation in Human : Study of Pro- and Anti-inflammatory Cytokines and ADIPOKINES.. Completed NCT00388323
21 Validation of an Accelerated Procedure of Selection in Early Liver Transplantation for Severe Alcoholic Hepatitis Not Responding to Medical Treatment QuickTransHAA. Completed NCT01756794
22 Randomised Open-label Multicenter Study Evaluating Ciprofloxacin in Severe Alcoholic Hepatitis in Addition to Prednisolon Therapy Completed NCT02326103 Early Phase 1 Ciprofloxacin;Placebo
23 A Study of Molecular and Genetic Factors for Liver Cancer in the Greater Baltimore Area Completed NCT00913757
24 Long-term Follow-up of Patients With Alcoholic Liver Cirrhosis Who Had Administered Cellgram-LC in PMC-P-07 Study Recruiting NCT05093881
25 A Multi-center, Randomized, Placebo-controlled Trial of S-Adenosylmethionine (SAMe) in Patients With Alcoholic Cirrhosis Recruiting NCT04250259
26 EUS Based Prevalence of Chronic Pancreatitis in Alcoholic Cirrhosis: Any Difference Between Alcoholic and Non-alcoholic Patients Recruiting NCT04245189
27 Mild Hypothermia and Acute Kidney Injury in Liver Transplantation (MHALT) Trial Recruiting NCT03534141
28 Study of Genetic Determinants in Alcoholic Hepatitis and Establishment of a Multicenter Prospective Cohort of Patients With Alcoholic Liver Disease Recruiting NCT04106518
29 Copenhagen Liver Cohort Study: Disease Characteristics, Outcomes and Rehabilitation in Liver Cirrhosis - A Prospective Cohort Study Recruiting NCT04422223
30 Profermin®: Prevention of Progression in Alcoholic Liver Disease by Modulating Dysbiotic Microbiota - a Randomized Controlled Clinical Trial Active, not recruiting NCT03863730
31 Early Detection of Advanced Liver Fibrosis in Patients With Excessive Alcohol Intake Not yet recruiting NCT04070508
32 A Randomized, Pragmatic, Outcome-assessor-blinded Study of an SMS-message-based Lifestyle Intervention in Patients With Decompensated Liver Cirrhosis Terminated NCT02811887

Search NIH Clinical Center for Alcoholic Liver Cirrhosis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Alcoholic Liver Cirrhosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Alcoholic Liver Cirrhosis:
Livercellgram, bone marrow-derived mesenchymal stem cells for treatment of alcoholic liver cirrhosis
Embryonic/Adult Cultured Cells Related to Alcoholic Liver Cirrhosis:
Bone marrow-derived mesenchymal stem cells

Cochrane evidence based reviews: liver cirrhosis, alcoholic

Genetic Tests for Alcoholic Liver Cirrhosis

Anatomical Context for Alcoholic Liver Cirrhosis

Organs/tissues related to Alcoholic Liver Cirrhosis:

MalaCards : Liver, Bone Marrow, Skin, Bone, Kidney, Smooth Muscle, Monocytes
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Alcoholic Liver Cirrhosis:
# Tissue Anatomical CompartmentCell Relevance
1 Liver Liver Lobule Hepatocytes Affected by disease

Publications for Alcoholic Liver Cirrhosis

Articles related to Alcoholic Liver Cirrhosis:

(show top 50) (show all 5024)
# Title Authors PMID Year
1
Association of polymorphism in alcohol dehydrogenase and interaction with other genetic risk factors with alcoholic liver cirrhosis. 53 62
20171022 2010
2
Myeloperoxidase and superoxide dismutase 2 polymorphisms comodulate the risk of hepatocellular carcinoma and death in alcoholic cirrhosis. 53 62
19731237 2009
3
Polymorphism in cytochrome P450 2E1 and interaction with other genetic risk factors and susceptibility to alcoholic liver cirrhosis. 53 62
19428381 2009
4
Polymorphism in glutathione-S-transferases: a risk factor in alcoholic liver cirrhosis. 53 62
19157724 2009
5
Hepatic ethanol elimination kinetics in patients with cirrhosis. 53 62
19404864 2009
6
Human serum fetuin A/alpha2HS-glycoprotein level is associated with long-term survival in patients with alcoholic liver cirrhosis, comparison with the Child-Pugh and MELD scores. 53 62
17394649 2007
7
[Serum cytokine concentration as prognostic factor in patients with alcoholic liver disease]. 53 62
17036498 2006
8
Risk factors for Staphylococcus aureus infection in liver transplant recipients. 53 62
16123951 2005
9
Redox active plasma iron in C282Y/C282Y hemochromatosis. 53 62
15671444 2005
10
Genetic dimorphism in superoxide dismutase and susceptibility to alcoholic cirrhosis, hepatocellular carcinoma, and death. 53 62
15765450 2005
11
[Genetic polymorphisms of alcohol-metabolizing enzymes and cytokines in patients with alcohol induced pancreatitis and alcoholic liver cirrhosis]. 53 62
15220553 2004
12
New concepts of the pathogenesis of alcoholic liver disease lead to novel treatments. 53 62
14720455 2004
13
Status of blood antioxidant enzymes in alcoholic cirrhosis. 53 62
14723322 2003
14
[Effects of genetic polymorphisms of ethanol-metabolizing enzymes on alcohol drinking behaviors]. 53 62
12824748 2003
15
Human fetuin/alpha2HS-glycoprotein level as a novel indicator of liver cell function and short-term mortality in patients with liver cirrhosis and liver cancer. 53 62
11943951 2002
16
HFE gene mutations in alcoholic and virus-related cirrhotic patients with hepatocellular carcinoma. 53 62
12003382 2002
17
[Studies on the mechanism of elevation of serum PIVKA-II levels in alcoholic liver cirrhosis]. 53 62
11985059 2002
18
Polymorphism in alcohol-metabolizing enzymes, glutathione S-transferases and apolipoprotein E and susceptibility to alcohol-induced cirrhosis and chronic pancreatitis. 53 62
11966948 2002
19
Free radical mechanisms in immune reactions associated with alcoholic liver disease. 53 62
11796198 2002
20
Lipid peroxidation contributes to immune reactions associated with alcoholic liver disease. 53 62
11755315 2002
21
Association between polymorphisms of ethanol-metabolizing enzymes and susceptibility to alcoholic cirrhosis in a Korean male population. 53 62
11748356 2001
22
Serum leptin levels in alcoholic liver cirrhosis: relationship with gender, nutritional status, liver function and energy metabolism. 53 62
11641747 2001
23
Serum iron parameters in patients with alcoholic and chronic cirrhosis and hepatitis. 53 62
11535942 2001
24
Hepatitis C and the leptin system: bound leptin levels are elevated in patients with hepatitis C and decrease during antiviral therapy. 53 62
11336170 2001
25
Serum leptin levels in patients with nonalcoholic chronic liver disease. 53 62
11379347 2001
26
Alcohol-related cirrhosis with pancreatitis. The role of oxidative stress in the progression of the disease. 53 62
11348018 2001
27
Serum cytokine levels in alcohol-related liver cirrhosis. 53 62
11282449 2001
28
Cytochromes P450 2A6, 2E1, and 3A and production of protein-aldehyde adducts in the liver of patients with alcoholic and non-alcoholic liver diseases. 53 62
11131450 2000
29
[Oxidative stress and antioxidant defense in alcoholic liver disease and chronic hepatitis C]. 53 62
10962902 2000
30
Serum levels of cytokines in alcoholic liver cirrhosis and pancreatitis. 53 62
11059648 2000
31
Oxidative stress in alcoholic liver disease. 53 62
10701300 1999
32
Interleukin-8 and alcoholic liver disease. 53 62
10418175 1999
33
N-acetyltransferase-2, glutathione S-transferase M1, alcohol dehydrogenase, and cytochrome P450IIE1 genotypes in alcoholic liver cirrhosis: a case-control study. 53 62
10232877 1999
34
[Liver function and the level of total cholesterol in the blood serum in liver cirrhosis]. 53 62
10204356 1998
35
Gender-dependent alterations in serum leptin in alcoholic cirrhosis. 53 62
9753498 1998
36
Distinct patterns of chemokine expression are associated with leukocyte recruitment in alcoholic hepatitis and alcoholic cirrhosis. 53 62
9875144 1998
37
Association studies of polymorphisms of CYP2E1 gene in alcoholics with cirrhosis, antisocial personality, and normal controls. 53 62
9660317 1998
38
[Serum levels of soluble interleukin-2 receptor in alcoholic patients]. 53 62
9608061 1998
39
Oxidative stress in the liver and biliary tract diseases. 53 62
9867111 1998
40
Plasminogen in patients with liver cirrhosis. 53 62
9253235 1997
41
Plasma glutathione S-transferase alpha 1-1 levels in patients with chronic liver disorders. 53 62
9049444 1997
42
T-cell activation, expression of adhesion molecules and response to ethanol in alcoholic cirrhosis. 53 62
8803617 1996
43
Deceptive prothrombin and activated partial thromboplastin times in alcoholic cirrhosis. 53 62
8667440 1996
44
Serum levels of interleukin-8 in alcoholic liver disease: relationship with disease stage, biochemical parameters and survival. 53 62
8738722 1996
45
Proportion of the GSTM1 0/0 genotype in some Slavic populations and its correlation with cystic fibrosis and some multifactorial diseases. 53 62
8834254 1996
46
Polymorphisms in alcohol metabolizing enzyme genes and alcoholic cirrhosis in Japanese patients: a multivariate analysis. 53 62
7557863 1995
47
Altered expression of monocyte IgA Fc receptors is associated with defective endocytosis in patients with alcoholic cirrhosis. Potential role for IFN-gamma. 53 62
7636220 1995
48
Genotypes of alcohol-metabolizing enzymes in Mexicans with alcoholic liver cirrhosis. 53 62
8845660 1995
49
Effects of large-volume paracentesis on pulmonary function in patients with tense cirrhotic ascites. 53 62
7927222 1994
50
[Blood chemistry, hematology of patients with liver cirrhosis]. 53 62
8114309 1994

Variations for Alcoholic Liver Cirrhosis

Expression for Alcoholic Liver Cirrhosis

Search GEO for disease gene expression data for Alcoholic Liver Cirrhosis.

Pathways for Alcoholic Liver Cirrhosis

Pathways related to Alcoholic Liver Cirrhosis according to GeneCards Suite gene sharing:

(show all 43)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.71 ADH1B ADH1C AKR1A1 ALB ALDH2 CYP2E1
2
Show member pathways
12.94 GSTP1 GSTM1 CYP2E1 ALDH2 AKR1A1 ADH1C
3
Show member pathways
12.8 TNF INS IL6 IL1B GAPDH
4 12.5 ADH1B AHSG GAPDH INS SOD2
5
Show member pathways
12.47 TNF IL6 IL1B CXCL8
6
Show member pathways
12.38 TNF IL6 IL1B CXCL8
7
Show member pathways
12.34 IL6 F2 ALB AHSG AFP
8
Show member pathways
12.29 TNF IL6 IL1B CXCL8
9 12.09 TNF IL6 IL1B GAPDH CXCL8
10 12.06 INS IL6 ALB AFP
11 12.04 TNF PLIN2 INS IL6
12 11.97 TNF IL6 IL1B CXCL8
13 11.93 TNF IL6 IL1B CXCL8
14 11.91 CXCL8 IL1B IL6 INS
15 11.74 IL6 CXCL8 AFP
16
Show member pathways
11.73 GSTP1 GSTM1 CYP2E1
17 11.71 TNF IL6 IL1B
18 11.71 CXCL8 IL1B IL6 TNF
19 11.63 TNF IL6 CXCL8
20 11.63 TNF IL6 IL1B
21
Show member pathways
11.62 TNF IL6 IL1B CXCL8
22 11.61 TNF IL6 IL1B CXCL8
23 11.59 INS IL6 CXCL8
24 11.53 CXCL8 IL6 TNF
25 11.47 TNF IL6 IL1B
26 11.43 TNF IL6 IL1B CXCL8
27 11.4 TNF INS IL6 CYP2E1
28
Show member pathways
11.39 CYP2E1 ALDH2 ADH1B
29 11.35 TNF IL6 IL1B
30
Show member pathways
11.34 INS F2 ALB AFP
31 11.29 TNF IL6 IL1B
32 11.24 TNF IL6 IL1B
33 11.16 ADH1B ADH1C ALDH2 CYP2E1
34 11.03 TNF IL6 IL1B CXCL8
35 11.02 TNF IL6 CXCL8
36 10.95 INS GPT GAPDH
37 10.9 TNF IL6 IL1B CXCL8
38 10.77 IL6 IL1B
39 10.68 IL6 CXCL8
40 10.64 GSTP1 GSTM1 CYP2E1 AKR1A1
41
Show member pathways
10.51 GSTP1 ALDH2 AKR1A1 ADH1C ADH1B
42 10.35 GSTM1 CYP2E1
43
Show member pathways
10.2 TNF IL6 CXCL8

GO Terms for Alcoholic Liver Cirrhosis

Cellular components related to Alcoholic Liver Cirrhosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.73 INS IL6 F2 ALB AHSG AFP
2 extracellular space GO:0005615 9.68 TNF INS IL6 IL1B GSTP1 GPT

Biological processes related to Alcoholic Liver Cirrhosis according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 cellular response to lipopolysaccharide GO:0071222 10.11 TNF IL6 IL1B GSTP1 CXCL8
2 regulation of insulin secretion GO:0050796 10.08 TNF IL6 IL1B
3 response to activity GO:0014823 10.08 TNF SOD2 IL6
4 positive regulation of nitric oxide biosynthetic process GO:0045429 10.06 TNF SOD2 IL1B
5 glutathione metabolic process GO:0006749 10.05 SOD2 GSTP1 GSTM1
6 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 10.02 TNF IL6 F2
7 positive regulation of mitotic nuclear division GO:0045840 10 TNF INS IL1B
8 positive regulation of chemokine production GO:0032722 9.99 TNF IL6 IL1B
9 positive regulation of cytokine production GO:0001819 9.98 TNF INS IL1B GAPDH
10 vasodilation GO:0042311 9.96 TNF SOD2 INS
11 negative regulation of neurogenesis GO:0050768 9.95 IL1B IL6 TNF
12 negative regulation of lipid catabolic process GO:0050995 9.88 IL1B INS TNF
13 positive regulation of fever generation GO:0031622 9.87 IL1B TNF
14 acute-phase response GO:0006953 9.86 INS IL6 F2 AHSG
15 positive regulation of glial cell proliferation GO:0060252 9.85 IL1B IL6 TNF
16 sequestering of triglyceride GO:0030730 9.84 TNF IL1B
17 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.81 TNF IL1B
18 aldehyde catabolic process GO:0046185 9.8 ALDH2 AKR1A1
19 positive regulation of neuroinflammatory response GO:0150078 9.8 TNF IL6 IL1B
20 alcohol metabolic process GO:0006066 9.46 ALDH2 ADH1C ADH1B
21 vascular endothelial growth factor production GO:0010573 9.43 TNF IL6 IL1B
22 glutathione derivative biosynthetic process GO:1901687 9.1 GSTP1 GSTM1 AKR1A1

Molecular functions related to Alcoholic Liver Cirrhosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 fatty acid binding GO:0005504 9.73 GSTP1 ALB AFP
2 oxygen binding GO:0019825 9.63 SOD2 CYP2E1 ALB
3 NAD-retinol dehydrogenase activity GO:0004745 9.35 AKR1A1 ADH1C ADH1B
4 oxidoreductase activity GO:0016491 9.23 SOD2 GAPDH CYP2E1 ALDH2 AKR1A1 ADH1C

Sources for Alcoholic Liver Cirrhosis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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