Alcoholic Liver Cirrhosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ALC009 MIFTS: 52	Alcoholic Liver Cirrhosis Categories: Gastrointestinal diseases, Endocrine diseases, Liver diseases
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Aliases & Classifications for Alcoholic Liver Cirrhosis

MalaCards integrated aliases for Alcoholic Liver Cirrhosis:

Name: Alcoholic Liver Cirrhosis ³⁸ ¹² ⁷⁶ ¹⁵

Portal Cirrhosis ¹² ⁵⁵ ⁷³

Liver Cirrhosis, Alcoholic ⁴⁴ ⁷³

Alcoholic Cirrhosis ¹² ⁵⁵

Laennec's Cirrhosis, Alcoholic ¹²

Alcoholic Cirrhosis of Liver ¹²

Laennec's Cirrhosis ¹²

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases Endocrine diseases Liver diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the digestive system

Diseases of liver

Alcoholic liver disease

Alcoholic cirrhosis of liver

External Ids:

Disease Ontology ¹² DOID:14018

ICD10 ³³ K70.3

ICD9CM ³⁵ 571.2

MeSH ⁴⁴ D008104

NCIt ⁵⁰ C34782

SNOMED-CT ⁶⁸ 155811002 197280008 235894003 more

UMLS ⁷³ C0023891 C1622502

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Summaries for Alcoholic Liver Cirrhosis

MalaCards based summary : Alcoholic Liver Cirrhosis, also known as portal cirrhosis, is related to antipyrine metabolism and peritonitis, and has symptoms including icterus An important gene associated with Alcoholic Liver Cirrhosis is ADH1B (Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide), and among its related pathways/superpathways are Metabolism and Cytochrome P450 - arranged by substrate type. The drugs Angiotensin II and Losartan have been mentioned in the context of this disorder. Affiliated tissues include Liver, liver and skin, and related phenotype is homeostasis/metabolism.

Wikipedia : ⁷⁶ Cirrhosis is a condition in which the liver does not function properly due to long-term damage. This... more...

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Related Diseases for Alcoholic Liver Cirrhosis

Diseases related to Alcoholic Liver Cirrhosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)

#	Related Disease	Score	Top Affiliating Genes
1	antipyrine metabolism	30.7	ALB F2
2	peritonitis	30.6	ALB CXCL8 F2
3	alcoholic pancreatitis	30.6	ADH1B ALDH2 CYP2E1
4	esophageal varix	30.3	AFP ALB F2
5	hepatic encephalopathy	29.8	ALB F2 SLC17A5
6	alcohol abuse	29.7	ALDH2 CYP2E1 SLC17A5 TF
7	hepatitis b	29.2	AFP ALB F2 SLC17A5
8	alcoholic hepatitis	29.0	ALB CXCL8 CYP2E1 F2 SLC17A5
9	viral hepatitis	28.9	AFP ALB F2 SLC17A5
10	liver cirrhosis	28.9	ADH1B AFP ALB ALDH2 CYP2E1 F2
11	nonalcoholic steatohepatitis	28.9	F2 PNPLA3 SLC17A5
12	fatty liver disease	28.9	CYP2E1 PNPLA3 SLC17A5
13	alcohol dependence	28.4	ADH1B ADH1C ADH4 ALDH2 CYP2E1 SLC17A5
14	liver disease	26.7	AFP ALB CYP2E1 F2 PNPLA3 SLC17A5
15	isoniazid toxicity	10.9	CYP2E1 NAT2
16	non-a-e hepatitis	10.7	ALB F2
17	phenytoin toxicity	10.7	ALB NAT2
18	fournier gangrene	10.7	ALB F2
19	abdominal tuberculosis	10.7	ALB F2
20	aspartylglucosaminuria	10.7	ADH1B ADH1C
21	methanol poisoning	10.7	ADH1B ADH1C CYP2E1
22	hepatic tuberculosis	10.7	ALB F2
23	sister chromatid exchange, frequency of	10.6	ALDH2 CYP2E1 GSTM1
24	scabies	10.6	CXCL8 GSTM1
25	pyuria	10.6	ALB CXCL8
26	yellow nail syndrome	10.6	ALB TF
27	marasmus	10.6	ALB TF
28	hepatic coma	10.6	ALB F2
29	orbital cyst	10.6	F2 TF
30	drug-induced hepatitis	10.6	CYP2E1 GSTM1 NAT2
31	splenic disease	10.5	ALB F2
32	haemophilus influenzae	10.5	CXCL8 TF
33	capillary leak syndrome	10.4	ALB CXCL8
34	hepatitis	10.4
35	ascending cholangitis	10.4	ALB F2
36	hepatoid adenocarcinoma	10.4	AFP ALB
37	alcoholic neuropathy	10.4	ADH4 ALDH2
38	inflammatory and toxic neuropathy	10.4	ADH4 ALDH2
39	halothane hepatitis	10.3	CYP2A6 CYP2E1
40	endometrial small cell carcinoma	10.3	AFP F2
41	nutritional deficiency disease	10.3	ALB F2 TF
42	wilson disease	10.3	ALB F2 TF
43	vitamin k deficiency hemorrhagic disease	10.3	AFP F2
44	immune system disease	10.3	ALB F2 TF
45	dengue hemorrhagic fever	10.3	ALB CXCL8 F2
46	tobacco addiction	10.3	ALDH2 CYP2A6 GSTM1
47	endocarditis	10.3	ALB CXCL8 F2
48	ariboflavinosis	10.3	ALB TF
49	trypanosomiasis	10.2	ALB CXCL8 TF
50	epstein-barr virus hepatitis	10.2	AHSG F2 TF

Comorbidity relations with Alcoholic Liver Cirrhosis via Phenotypic Disease Network (PDN): (show all 26)

Acquired Thrombocytopenia	Active Peptic Ulcer Disease
Acute Cystitis	Acute Kidney Failure
Acute Pancreatitis	Alcohol Abuse
Alcoholic Cardiomyopathy	Alcoholic Gastritis
Alcoholic Hepatitis	Alcoholic Neuropathy
Chronic Congestive Splenomegaly	Chronic Kidney Failure
Deficiency Anemia	Esophageal Varix
Familial Atrial Fibrillation	Fatty Liver Disease
Heart Disease	Hepatic Encephalopathy
Hepatocellular Carcinoma	Hepatorenal Syndrome
Hypersplenism	Iron Deficiency Anemia
Portal Hypertension	Protein-Energy Malnutrition
Respiratory Failure	Urea Cycle Disorder

Graphical network of the top 20 diseases related to Alcoholic Liver Cirrhosis:

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Symptoms & Phenotypes for Alcoholic Liver Cirrhosis

UMLS symptoms related to Alcoholic Liver Cirrhosis:

icterus

MGI Mouse Phenotypes related to Alcoholic Liver Cirrhosis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	9.36	PNPLA3 SLC17A5 TF ADH1C AFP AHSG

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Drugs & Therapeutics for Alcoholic Liver Cirrhosis

Drugs for Alcoholic Liver Cirrhosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 96)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Angiotensin II

Approved, Investigational

Phase 4

68521-88-0, 4474-91-3, 11128-99-7

172198 65143

Losartan

Approved

Phase 4

114798-26-4

3961

Propranolol

Approved, Investigational

Phase 4,Not Applicable

525-66-6

4946

Spironolactone

Approved

Phase 4,Not Applicable

1952-01-7, 52-01-7

5833

Angiotensin II Type 1 Receptor Blockers

Phase 4

Angiotensin Receptor Antagonists

Phase 4

Angiotensinogen

Phase 4

Anti-Arrhythmia Agents

Phase 4

Antihypertensive Agents

Phase 4

Liver Extracts

Phase 4,Phase 3,Phase 2,Not Applicable

Hormone Antagonists

Phase 4,Phase 2

Hormones

Phase 4,Phase 2

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 4,Phase 2

Adrenergic Agents

Phase 4

Adrenergic Antagonists

Phase 4

Adrenergic beta-Antagonists

Phase 4

diuretics

Phase 4

Diuretics, Potassium Sparing

Phase 4

Mineralocorticoid Receptor Antagonists

Phase 4

Mineralocorticoids

Phase 4

Natriuretic Agents

Phase 4

Neurotransmitter Agents

Phase 4

Vasodilator Agents

Phase 4

Baclofen

Approved

Phase 3

1134-47-0

2284

Ethanol

Approved

Phase 3,Not Applicable

64-17-5

702

Everolimus

Approved

Phase 3

159351-69-6

6442177

Miconazole

Approved, Investigational, Vet_approved

Phase 3

22916-47-8

4189

Sirolimus

Approved, Investigational

Phase 3

53123-88-9

5284616 6436030 46835353

Tacrolimus

Approved, Investigational

Phase 3

104987-11-3

445643 439492

Naltrexone

Approved, Investigational, Vet_approved

Phase 3

16590-41-3

5360515

Benzocaine

Approved, Investigational

Phase 3

1994-09-7, 94-09-7

2337

Iron

Approved

Phase 3

7439-89-6

23925

tannic acid

Approved, Nutraceutical

Phase 3

Anti-Bacterial Agents

Phase 3,Phase 2,Early Phase 1

Anti-Infective Agents

Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Anti-Infective Agents, Local

Phase 3,Not Applicable

Central Nervous System Depressants

Phase 3,Not Applicable

Antibiotics, Antitubercular

Phase 3

Antifungal Agents

Phase 3

Calcineurin Inhibitors

Phase 3

Immunosuppressive Agents

Phase 3

Cobalt

Phase 3

7440-48-4

104729

Narcotic Antagonists

Phase 3

Narcotics

Phase 3

Peripheral Nervous System Agents

Phase 3

Prednisone

Approved, Vet_approved

Phase 2

53-03-2

5865

Rifaximin

Approved, Investigational

Phase 2

80621-81-4

6436173

Caffeine

Approved, Nutraceutical

Phase 2

58-08-2

2519

Anti-Inflammatory Agents

Phase 2,Not Applicable

Antineoplastic Agents, Hormonal

Phase 2

Interventional clinical trials:

(show all 37)

#	Name	Status	NCT ID	Phase	Drugs
1	Prevention of Decompensation in Liver Cirrhosis	Unknown status	NCT00239096	Phase 4	losartan (drug)
2	Hemodynamic Effects of Chronic Administration of Spironolactone and/or Propranolol in Alcoholic Cirrhotic Patients	Terminated	NCT00188045	Phase 4	Propranolol - Spironolactone
3	Baclofen in the Treatment of Alcohol Dependence With or Without Alcoholic Liver Disease	Completed	NCT01711125	Phase 3	Baclofen 30mg/day;Baclofen 75mg/day;Placebo
4	REnal Function in Liver Transplantation: Everolimus With Calcineurin Inhibitor (CNI)-Sparing sTrategy	Recruiting	NCT02115113	Phase 3	Everolimus;Everolimus;Tacrolimus
5	Proton Radiotherapy Versus Radiofrequency Ablation for Patients With Medium or Large Hepatocellular Carcinoma	Recruiting	NCT02640924	Phase 3
6	Nalmefene in Patients With Alcoholic Compensated Cirrhosis for the Treatment of Alcohol Dependence.	Not yet recruiting	NCT02824354	Phase 3	Nalmefene (Selincro®) 18 mg tablet;placebo
7	Phlebotomy and Risk of Hepatocellular Carcinoma in Patients With Compensated Alcoholic Cirrhosis	Terminated	NCT01342705	Phase 3
8	The Effectiveness and Safety for Mesenchymal Stem Cell for Alcoholic Liver Cirrhosis	Unknown status	NCT01741090	Phase 2
9	REVIVE(Randomized Exploratory Clinical Trial to Evaluate the Safety and Effectiveness of Stem Cell Product in Alcoholic Liver Cirrhosis Patient)	Completed	NCT01875081	Phase 2
10	Dose Finding Study to Assess Safety and Efficacy of Stem Cells in Liver Cirrhosis	Completed	NCT01591200	Phase 2
11	A Phase II, Double-blinded, Randomized, Controlled Study to Evaluate the Efficacy and Safety of Vitalliver in Patients With Decompensated Cirrhosis	Completed	NCT00562783	Phase 2	Vitaliver;Placebo
12	Long-term Follow-up Study of Livercellgram in Alcoholic Liver Cirrhosis Patients Who Completed Livercellgram Phase 2 Study	Enrolling by invitation	NCT02806011	Phase 2
13	Effects of Rifaximin in Patients With Acute Alcoholic Hepatitis	Enrolling by invitation	NCT02116556	Phase 2	Prednisone;Rifaximin
14	Pharmacokinetics (PK) of Tipranavir/Ritonavir, Ribavirin, Pegylated Interferon (Peg INF) in Hepatitis C (HCV) Subjects With Mild Hepatic Impairment and in HCV, Hepatitis B (HBV), Hepatitis D Infected Subjects or Alcoholic Cirrhosis With Moderate Hepatic I	Completed	NCT02259855	Phase 1	Tipranavir;Ritonavir;Pegylated interferon;Ribavirin
15	Pangenomic Study During Alcoholic Cirrhosis	Unknown status	NCT01065233
16	Measurement of Fibrinogen in Patients With Systemic Inflammatory Response Syndrome (SIRS), Sepsis or Chronicle Liver Disease on Intensive Care Units (ICU)	Unknown status	NCT01169168
17	Prospective Analysis Of Cardiac Function In Cirrhotic Patients By Echocardiography And Its Correlation With Events	Unknown status	NCT01433848
18	Indocyanine Green and Portal Pressure in Viral and Alcoholic Cirrhotic Patients With Hepatocarcinoma	Unknown status	NCT00827723
19	FGL2/Fibroleukin and Hepatitis C Virus Recurrence Post Liver Transplantation	Unknown status	NCT00701272
20	Liver Transplantation Versus Alternative Therapies for Patients With Pugh B Alcoholic Cirrhosis	Completed	NCT00701792	Not Applicable
21	Adipose Tissue Involvement in Alcohol-induced Liver Inflammation in Human	Completed	NCT00388323	Not Applicable
22	Randomised Open-label Multicenter Study Evaluating Ciprofloxacin in Severe Alcoholic Hepatitis	Completed	NCT02326103	Early Phase 1	Ciprofloxacin;Placebo
23	Influence of Probiotics on Infections in Cirrhosis	Completed	NCT01607528	Not Applicable
24	Biomarkers for the Prognosis of Decompensated Alcoholic Liver Disease	Completed	NCT01701687
25	Acoustic Liver Biopsy in Normals and in Patients With Cirrhosis Using Endoscopic Ultrasound	Completed	NCT01208311
26	Subclinical Myocardial Dysfunction in Patients With Hepatic Cirrhosis	Completed	NCT01713478	Not Applicable
27	Value on Survival of Liver Volume After an Acute Decompensation of an Alcoholic Cirrhosis	Recruiting	NCT03508388
28	Safety and Performance Trial of DIALIVE Liver Dialysis Device in Acute On Chronic Liver Failure Patients	Recruiting	NCT03065699	Not Applicable
29	Assessment of Nutritional Status of Patients With Liver Cirrhosis	Recruiting	NCT03242798
30	Mild Hypothermia and Acute Kidney Injury in Liver Transplantation	Recruiting	NCT03534141	Not Applicable
31	Comparison of ALD, NASH, and Healthy Control Patients	Recruiting	NCT03224949
32	Boramae Hospital Liver Cirrhosis Patient Cohort Study	Recruiting	NCT01943318
33	National Cohort of Uncomplicated Alcoholic Cirrhosis	Active, not recruiting	NCT01213927
34	Validation of the Procedure of Early Liver Transplantation in Alcoholic Hepatitis Resisting to Medical Treatment	Active, not recruiting	NCT01756794	Not Applicable
35	Zinc Supplementation in Alcoholic Cirrhosis	Active, not recruiting	NCT02072746	Not Applicable
36	Prevalence of Exocrine Pancreatic Insufficiency in Patients With Decompensated Cirrhosis	Not yet recruiting	NCT03236038
37	Influence of ABO Blood Group on the Risk of Complications in Alcoholic or Viral C Cirrhosis?	Not yet recruiting	NCT03342170

Search NIH Clinical Center for Alcoholic Liver Cirrhosis

Cell-based therapeutics:

Data from LifeMap, the Embryonic Development and Stem Cells Database

Read about Alcoholic Liver Cirrhosis cell therapies at LifeMap Discovery.

Stem-cell-based therapeutic approaches for Alcoholic Liver Cirrhosis:

Livercellgram, bone marrow-derived mesenchymal stem cells for treatment of alcoholic liver cirrhosis

Embryonic/Adult Cultured Cells Related to Alcoholic Liver Cirrhosis:

Bone marrow-derived mesenchymal stem cells

Cochrane evidence based reviews: liver cirrhosis, alcoholic

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Genetic Tests for Alcoholic Liver Cirrhosis

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Anatomical Context for Alcoholic Liver Cirrhosis

MalaCards organs/tissues related to Alcoholic Liver Cirrhosis:

⁴¹

Liver, Skin, Bone, Kidney, Monocytes, Small Intestine, Bone Marrow

Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Alcoholic Liver Cirrhosis:

#	Tissue Anatomical CompartmentCell	Relevance
1	Liver Liver Lobule Hepatocytes	Affected by disease

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Publications for Alcoholic Liver Cirrhosis

Articles related to Alcoholic Liver Cirrhosis:

(show top 50) (show all 258)

#	Title	Authors	Year
1	The Impact of Outpatient Clinical Care on the Survival and Hospitalisation Rate in Patients with Alcoholic Liver Cirrhosis. ( 29520208 )	Majc D....Tepes B.	2018
2	Circulating Endothelial Progenitor Cells Present an Inflammatory Phenotype and Function in Patients With Alcoholic Liver Cirrhosis. ( 29872403 )	Kaur S....Seth D.	2018
3	Number of hospital contacts with alcohol problems predicts later risk of alcoholic liver cirrhosis. ( 29528775 )	Askgaard G....KjA	2018
4	VALIDATION OF CLIF-C-ACLF SCORE FOR ALCOHOLIC LIVER CIRRHOSIS. ( 29905553 )	Slyvka N....Abdelrahman F.	2018
5	Gallbladder perforation in a patient with alcoholic liver cirrhosis and asymptomatic gallstones: A case report. ( 29718836 )	Shi X....Wang G.	2018
6	A study of serological markers and lipid profile in non-alcoholic liver cirrhosis patients. ( 29348089 )	Khan S....Jamal S.	2018
7	Successful Distal Gastrectomy for Gastric Cancer with Child-Pugh Class B Alcoholic Liver Cirrhosis. ( 29715144 )	Iwabu J....Hanazaki K.	2018
8	Vitamin D supplementation in patients with alcoholic liver cirrhosis: a prospective study. ( 29963831 )	SaviA8 A.1....Abenavoli L.	2018
9	Characterization of Body Composition and Definition of Sarcopenia in Patients with Alcoholic Liver Cirrhosis: a Computed Tomography Based Study. ( 28665532 )	Benjamin J....Sarin S.K.	2017
10	Diagnostic specificity and sensitivity of PIVKAII, GP3, CSTB, SCCA1 and HGF for the diagnosis of hepatocellular carcinoma in patients with alcoholic liver cirrhosis. ( 28766361 )	UniA8 A....GrgureviA8 I.	2017
11	A tip from the nose: rhinocerebral mucormycosis in a patient with alcoholic liver cirrhosis and cocaine abuse, an uncommon association. ( 28784893 )	Avelar Rodriguez D....Miranda Ackerman R.C.	2017
12	Cost of illness of non-alcoholic liver cirrhosis in Japan: A time trend analysis and future projections. ( 28497644 )	Kitazawa T....Hasegawa T.	2017
13	Bacteremia Caused by Campylobacter Fetus in a Patient With Hepatitis B Virus Infection Complicated with Alcoholic Liver Cirrhosis. ( 28879715 )	Chen Y....Wu Z.	2017
14	Disialo-Trisialo Bridging Phenomenon of Transferrin Isoform Detected by Capillary Electrophoresis in Patient with Alcoholic Liver Cirrhosis: First Case Report from Asia. ( 28271694 )	Yang H.S....Cho S.Y.	2017
15	Data on gut metagenomes of the patients with alcoholic dependence syndrome and alcoholic liver cirrhosis. ( 28138508 )	Tyakht A.V....Govorun V.M.	2017
16	Relationships between serum selenium and zinc concentrations versus profibrotic and proangiogenic cytokines (FGF-19 and endoglin) in patients with alcoholic liver cirrhosis. ( 28954507 )	Prystupa A....Panasiuk L.	2017
17	Association between Serum Selenium Concentrations and Levels of Proinflammatory and Profibrotic Cytokines-Interleukin-6 and Growth Differentiation Factor-15, in Patients with Alcoholic Liver Cirrhosis. ( 28430124 )	Prystupa A....ZaA8uska W.	2017
18	Reduced platelet activation and platelet aggregation in patients with alcoholic liver cirrhosis. ( 28895774 )	Vinholt P.J....Nybo M.	2017
19	Lispro insulin in people with non-alcoholic liver cirrhosis and type 2 diabetes mellitus. ( 26803356 )	Gentile S....Ceriello A.	2016
20	Letter to the editor: treatment for superficial esophageal cancer with rectal varices bleeding in a patient with alcoholic liver cirrhosis. ( 26728025 )	Liu C.A....Jin X.F.	2016
21	A study on hematological spectrum in patients with alcoholic liver cirrhosis. ( 27727674 )	U A.R....Aggarwal H.K.	2016
22	A Single Nucleotide Polymorphism in the RASGRF2 Gene Is Associated with Alcoholic Liver Cirrhosis in Men. ( 27992614 )	Novo-Veleiro I....Marcos M.	2016
23	Serum Concentrations of Selected Heavy Metals in Patients with Alcoholic Liver Cirrhosis from the Lublin Region in Eastern Poland. ( 27304961 )	Prystupa A....ZaA8uska W.	2016
24	Length of Variable Numbers of Tandem Repeats in the Carboxyl Ester Lipase (CEL) Gene May Confer Susceptibility to Alcoholic Liver Cirrhosis but Not Alcoholic Chronic Pancreatitis. ( 27802312 )	Fjeld K....Rosendahl J.	2016
25	Behavior of Oxidative Stress Markers in Alcoholic Liver Cirrhosis Patients. ( 28074118 )	Galicia-Moreno M....Gutierrez-Reyes G.	2016
26	Risk for alcoholic liver cirrhosis after an initial hospital contact with alcohol problems: A nationwide prospective cohort study. ( 27862159 )	Askgaard G....Tolstrup J.S.	2016
27	CLIF-SOFA score and SIRS are independent prognostic factors in patients with hepatic encephalopathy due to alcoholic liver cirrhosis. ( 27367990 )	Jeong J.H....Lee S.B.	2016
28	Henoch-SchAPnlein purpura nephritis and colitis in an adult patient with alcoholic liver cirrhosis. ( 27668165 )	Jung J.H.	2016
29	Concentrations of fetuin-A, osteoprotegerin and I+-Klotho in patients with alcoholic liver cirrhosis. ( 27882180 )	Prystupa A....Dzida G.	2016
30	Aldehyde Dehydrogenase 2 (ALDH2) Polymorphism and the Risk of Alcoholic Liver Cirrhosis among East Asians: A Meta-Analysis. ( 27189280 )	He L....Luo H.	2016
31	Confluent hepatic fibrosis in alcohol liver cirrhosis with elevated pivkaii value - usefulness of immunostaining for EZH2 and p16(INK4a) in differentiating it from cholangiolocellular carcinoma - Confluent hepatic fibrosis. ( 27418411 )	Kim S.K....Hayashi Y.	2016
32	Hypothyroidism Enhanced Portal Hypertension in a Patient with Alcoholic Liver Cirrhosis, Resulting in the Development of Ascites. ( 26370856 )	Kakisaka K....Takikawa Y.	2015
33	Plasma osteopontin is a biomarker for the severity of alcoholic liver cirrhosis, not for hepatocellular carcinoma screening. ( 26122937 )	SimALo A....Carvalho A.	2015
34	Genetic polymorphism in alcohol dehydrogenase 2 (ADH2) gene and alcoholic liver cirrhosis risk. ( 26221330 )	He L....Luo H.S.	2015
35	Predictors of hepatorenal syndrome in alcoholic liver cirrhosis. ( 25820623 )	Janicko M....Jarcuska P.	2015
36	Alcohol dehydrogenase 1C (ADH1C) gene polymorphism and alcoholic liver cirrhosis risk: a meta analysis. ( 26379912 )	He L....Luo H.S.	2015
37	Flavobacterium ceti From Blood Samples of a Korean Patient With Alcoholic Liver Cirrhosis. ( 25932454 )	Sung J.Y....Kim E.C.	2015
38	Activity of MMP1 and MMP13 and Amino Acid Metabolism in Patients with Alcoholic Liver Cirrhosis. ( 25863779 )	Prystupa A....ZaA8uska W.	2015
39	Circulating Lipids Are Associated with Alcoholic Liver Cirrhosis and Represent Potential Biomarkers for Risk Assessment. ( 26107182 )	Meikle P.J....Seth D.	2015
40	Alcohol drinking pattern and risk of alcoholic liver cirrhosis: A prospective cohort study. ( 25634330 )	Askgaard G....nbA	2015
41	Alcoholic Liver Cirrhosis and Significant Risk Factors for the Development of Alcohol-related Hepatocellular Carcinoma--Japan, 2012. ( 26946783 )	Kikuchi M....Kanai T.	2015
42	A variant in the nuclear dot protein 52kDa gene increases the risk for spontaneous bacterial peritonitis in patients with alcoholic liver cirrhosis. ( 26493630 )	Lutz P....Nischalke H.D.	2015
43	Proinflammatory Cytokines (IL-1I+, IL-6) and Hepatocyte Growth Factor in Patients with Alcoholic Liver Cirrhosis. ( 26448742 )	Prystupa A....ZaA8uska W.	2015
44	Alcohol abuse and alcoholic liver cirrhosis leading to spontaneous muscle hematoma: an event fraught with danger. ( 25969676 )	Mangla A....Telfer M.	2015
45	Aldehyde dehydrogenase 2 polymorphism influences development to hepatocellular carcinoma in East Asian alcoholic liver cirrhosis. ( 25778454 )	Abe H....Aizawa Y.	2015
46	Successful treatment of invasive gastric mucormycosis in a patient with alcoholic liver cirrhosis: A case report. ( 25009590 )	Lee S.H....Ryu S.W.	2014
47	Vitamin D status, bone metabolism and bone mass in patients with alcoholic liver cirrhosis. ( 25318918 )	Savic Z....Nikolic S.	2014
48	Interleukin 10 promoter haplotype is associated with alcoholic liver cirrhosis in Taiwanese patients. ( 24835349 )	Yang A.M....Bair M.J.	2014
49	Correlation between hepatic blood flow and liver function in alcoholic liver cirrhosis. ( 25493018 )	Takahashi H....Suzuki M.	2014
50	Systematic review with meta-analysis: the I148M variant of patatin-like phospholipase domain-containing 3 gene (PNPLA3) is significantly associated with alcoholic liver cirrhosis. ( 25060292 )	Chamorro A.J....Marcos M.	2014

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Genes for Alcoholic Liver Cirrhosis

Genes related to Alcoholic Liver Cirrhosis (0 elite genes):

(show all 16)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	ADH1B	Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide	Protein Coding	32.35	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	15220553 8845660 11748356 (more) 11966948 7557863
2	CYP2E1	Cytochrome P450 Family 2 Subfamily E Member 1	Protein Coding	31.28	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	19428381 11748356 20171022 (more) 9660317 14720455 11966948 15220553 19157724 11796198
3	ALB	Albumin	Protein Coding	31.14	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	2123913 7678368 8114309 (more) 7927222 11755315 9608061 9253235
4	ALDH2	Aldehyde Dehydrogenase 2 Family Member	Protein Coding	31.09	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	12824748 15220553 8845660 (more) 11748356 11966948
5	F2	Coagulation Factor II, Thrombin	Protein Coding	30.87	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	16123951 8667440 9608061 (more) 9253235
6	GSTM1	Glutathione S-Transferase Mu 1	Protein Coding	26.56	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	19157724 20171022 19428381 (more) 8834254 11966948
7	TF	Transferrin	Protein Coding	26.31	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	15671444 11535942 12003382
8	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	25.55	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	11282449 8738722 15220553 (more) 9875144 11059648 10418175 8325620 17036498
9	ADH1C	Alcohol Dehydrogenase 1C (Class I), Gamma Polypeptide	Protein Coding	25.39	Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	1592339 15220553 11748356 (more) 11966948
10	AHSG	Alpha 2-HS Glycoprotein	Protein Coding	25.17	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	17394649 11943951
11	CYP2A6	Cytochrome P450 Family 2 Subfamily A Member 6	Protein Coding	24.05	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	11131450
12	SLC17A5	Solute Carrier Family 17 Member 5	Protein Coding	23.39	Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	9049444 1916663
13	ADH4	Alcohol Dehydrogenase 4 (Class II), Pi Polypeptide	Protein Coding	23.31	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
14	PNPLA3	Patatin Like Phospholipase Domain Containing 3	Protein Coding	22.62	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
15	NAT2	N-Acetyltransferase 2	Protein Coding	22.5	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	10232877
16	AFP	Alpha Fetoprotein	Protein Coding	22.38	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : DISEASES inferred (show sections)	16784653 18699979 17416468 (more) 20305756

Sources

Variations for Alcoholic Liver Cirrhosis

Sources

Expression for Alcoholic Liver Cirrhosis

Search GEO for disease gene expression data for Alcoholic Liver Cirrhosis.

Sources

Pathways for Alcoholic Liver Cirrhosis

Pathways related to Alcoholic Liver Cirrhosis according to GeneCards Suite gene sharing:

(show all 18)

#	Super pathways	Score	Top Affiliating Genes
1	Metabolism ⁶⁶ Show member pathways Metabolic pathways ³⁷ Metabolism of lipids and lipoproteins ⁶⁶	13.89	ADH1B ADH1C ADH4 ALB ALDH2 CYP2A6
2	Cytochrome P450 - arranged by substrate type ⁶⁶ Show member pathways Amine Oxidase reactions ⁶⁶ Aryl hydrocarbon receptor signalling ⁶⁶ Benzo(a)pyrene metabolism ¹ Biological oxidations ⁶⁶ bupropion degradation ¹ Clobazam Pathway, Pharmacokinetics ⁶¹ CYP2E1 reactions ⁶⁶ Cytosolic sulfonation of small molecules ⁶⁶ Diclofenac Metabolic Pathway ¹ Eicosanoids ⁶⁶ Endogenous sterols ⁶⁶ Estradiol metabolism ²² Ethanol oxidation ⁶⁶ Fatty Acid Omega Oxidation ¹ Fatty acids ⁶⁶ Metapathway biotransformation ¹ Methylation ⁶⁶ Miscellaneous substrates ⁶⁶ Oxidation by Cytochrome P450 ¹ Phase 1 - Functionalization of compounds ⁶⁶ Phase II conjugation ⁶⁶ Sterols are 12-hydroxylated by CYP8B1 ⁶⁶ Transport and synthesis of PAPS ⁶⁶ Vitamin D2 (ergocalciferol) metabolism ²² vitamin D3 biosynthesis ¹ Vitamins ⁶⁶ Xenobiotics ⁶⁶	12.86	ADH1B ADH1C ADH4 ALDH2 CYP2A6 CYP2E1
3	Glucose metabolism ⁶⁶ Show member pathways gluconeogenesis ¹ Gluconeogenesis ⁶⁶ glycogen biosynthesis ¹ Glycogen breakdown (glycogenolysis) ⁶⁶ Glycogen storage disease type 0 (liver GYS2) ⁶⁶ Glycogen storage disease type II (GAA) ⁶⁶ Glycogen storage disease type IV (GBE1) ⁶⁶ Glycogen synthesis ⁶⁶ glycolysis ¹ Glycolysis ⁶⁶ Glycolysis / Gluconeogenesis ³⁷ Glycolysis and Gluconeogenesis ¹ Glycolysis and gluconeogenesis (short map) ²² Lysosomal glycogen catabolism ⁶⁶ malate-aspartate shuttle ¹	12.46	ADH1B ADH1C ADH4 ALDH2
4	superpathway of tryptophan utilization ¹ Show member pathways glutaryl-CoA degradation ¹ melatonin degradation I ¹ NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde ¹ NAD Biosynthesis II (from tryptophan) ¹ NAD de novo biosynthesis ¹ serotonin degradation ¹ superpathway of melatonin degradation ¹ tryptophan degradation via tryptamine ¹ Tryptophan metabolism ¹ Tryptophan metabolism ³⁷	12.04	ADH1B ALDH2 CYP2A6 CYP2E1
5	Drug metabolism - cytochrome P450 ³⁷ Show member pathways Aflatoxin B1 metabolism ¹ Arylamine metabolism ¹ Benzo[a]pyrene metabolism ²² Benzodiazepine Pathway, Pharmacokinetics ⁶¹ Celecoxib Pathway, Pharmacokinetics ⁶¹ Chemical carcinogenesis ³⁷ Drug metabolism - other enzymes ³⁷ Fluvoxamine Pathway, Pharmacokinetics ⁶¹ Haloperidol Pathway, Pharmacokinetics ⁶¹ Ifosfamide Pathway, Pharmacokinetics ⁶¹ Metabolism of xenobiotics by cytochrome P450 ³⁷ Naproxen Pathway, Pharmacokinetics ⁶¹ Oxycodone Pathway, Pharmacokinetics ⁶¹ Retinol metabolism ³⁷ Retinol metabolism ²² Voriconazole Pathway, Pharmacokinetics ⁶¹	11.92	ADH1B ADH1C ADH4 ALDH2 CYP2A6 CYP2E1
6	Fatty acid metabolism ³⁷ Show member pathways Fatty acid degradation ³⁷	11.67	ADH1B ADH1C ADH4 ALDH2
7	Acetaminophen Pathway (therapeutic doses), Pharmacokinetics ⁶¹ Show member pathways 2-Naphthylamine and 2-Nitronaphtalene metabolism ²² Acetaminophen metabolism ²² Acetaminophen Pathway (toxic doses), Pharmacokinetics ⁶¹	11.61	CYP2A6 CYP2E1 GSTM1
8	Tyrosine metabolism ³⁷ Show member pathways Phenylalanine metabolism ³⁷ Phenylalanine, tyrosine and tryptophan biosynthesis ³⁷ Tyrosine metabolism p.1 (dopamine) ²²	11.58	ADH1B ADH1C ADH4
9	FOXA2 and FOXA3 transcription factor networks ¹	11.3	AFP ALB F2
10	Caffeine Pathway, Pharmacokinetics ⁶¹ Show member pathways Acetylation ⁶⁶ Caffeine and Theobromine metabolism ¹ Caffeine metabolism ³⁷ estradiol biosynthesis II ¹ Felbamate Metabolism ¹ Gut-Liver Indole Metabolism ¹ Theophylline Pathway, Pharmacokinetics ⁶¹	11.06	CYP2A6 CYP2E1 NAT2
11	Naphthalene metabolism ²²	10.99	CYP2A6 CYP2E1 GSTM1
12	Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics ⁶¹	10.87	CYP2A6 CYP2E1
13	Cyclophosphamide Pathway, Pharmacodynamics ⁶¹ Show member pathways Ifosfamide Pathway, Pharmacodynamics ⁶¹	10.75	ADH1B ADH1C ADH4 ALDH2
14	ethanol degradation II ¹ Show member pathways acetate conversion to acetyl-CoA ¹ ethanol degradation IV ¹ oxidative ethanol degradation III ¹	10.72	ADH1B ALDH2 CYP2E1
15	noradrenaline and adrenaline degradation ¹ Show member pathways Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB ⁶⁶ dopamine degradation ¹ L-dopa degradation ¹	10.67	ADH1B ADH4 ALDH2
16	Abacavir Pathway, Pharmacokinetics/Pharmacodynamics ⁶¹	10.66	ADH1B ADH1C
17	acetone degradation I (to methylglyoxal) ¹ Show member pathways methylglyoxal degradation III ¹	10.37	ADH1B CYP2A6 CYP2E1
18	Benzene metabolism ¹	10.29	CYP2E1 GSTM1

Sources

GO Terms for Alcoholic Liver Cirrhosis

Cellular components related to Alcoholic Liver Cirrhosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	blood microparticle	GO:0072562	9.26	AHSG ALB F2 TF
2	endoplasmic reticulum lumen	GO:0005788	9.02	AFP AHSG ALB F2 TF

Biological processes related to Alcoholic Liver Cirrhosis according to GeneCards Suite gene sharing:

(show all 11)

#	Name	GO ID	Score	Top Affiliating Genes
1	post-translational protein modification	GO:0043687	9.71	AFP AHSG ALB TF
2	oxidation-reduction process	GO:0055114	9.63	ADH1B ADH1C ADH4 ALDH2 CYP2A6 CYP2E1
3	platelet degranulation	GO:0002576	9.54	AHSG ALB TF
4	xenobiotic metabolic process	GO:0006805	9.5	CYP2A6 CYP2E1 NAT2
5	drug metabolic process	GO:0017144	9.49	CYP2A6 CYP2E1
6	exogenous drug catabolic process	GO:0042738	9.48	CYP2A6 CYP2E1
7	organic acid metabolic process	GO:0006082	9.46	CYP2A6 CYP2E1
8	epoxygenase P450 pathway	GO:0019373	9.43	CYP2A6 CYP2E1
9	cellular protein metabolic process	GO:0044267	9.35	AFP AHSG ALB F2 TF
10	alcohol metabolic process	GO:0006066	9.26	ADH4 ALDH2
11	ethanol oxidation	GO:0006069	8.92	ADH1B ADH1C ADH4 ALDH2

Molecular functions related to Alcoholic Liver Cirrhosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	oxidoreductase activity	GO:0016491	9.43	ADH1B ADH1C ADH4 ALDH2 CYP2A6 CYP2E1
2	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	GO:0016712	9.4	CYP2A6 CYP2E1
3	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	GO:0016620	9.37	ADH4 ALDH2
4	retinol dehydrogenase activity	GO:0004745	9.32	ADH1C ADH4
5	arachidonic acid epoxygenase activity	GO:0008392	9.26	CYP2A6 CYP2E1
6	alcohol dehydrogenase (NAD) activity	GO:0004022	9.16	ADH1C ADH4
7	alcohol dehydrogenase activity, zinc-dependent	GO:0004024	8.8	ADH1B ADH1C ADH4

Sources

Sources for Alcoholic Liver Cirrhosis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia