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MCID: ALC009
MIFTS: 54

Alcoholic Liver Cirrhosis

Categories: Gastrointestinal diseases, Liver diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Alcoholic Liver Cirrhosis

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MalaCards integrated aliases for Alcoholic Liver Cirrhosis:

Name: Alcoholic Liver Cirrhosis 12 73 15 37 17
Alcoholic Cirrhosis 12 54 15
Portal Cirrhosis 12 54 70
Alcoholic Cirrhosis of Liver 12 32
Liver Cirrhosis, Alcoholic 44 70
Laennec's Cirrhosis, Alcoholic 12
Laennec's Cirrhosis 12

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases Liver diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:14018
ICD9CM 34 571.2
MeSH 44 D008104
NCIt 50 C34782
SNOMED-CT 67 420054005
ICD10 32 K70.3
UMLS 70 C0023891 C1622502
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Summaries for Alcoholic Liver Cirrhosis

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MalaCards based summary : Alcoholic Liver Cirrhosis, also known as alcoholic cirrhosis, is related to varicose veins and peritonitis, and has symptoms including icterus An important gene associated with Alcoholic Liver Cirrhosis is CYP2E1 (Cytochrome P450 Family 2 Subfamily E Member 1), and among its related pathways/superpathways are Cytochrome P450 - arranged by substrate type and Pathways in cancer. The drugs Losartan and Angiotensin II have been mentioned in the context of this disorder. Affiliated tissues include Liver, bone and bone marrow, and related phenotypes are liver/biliary system and neoplasm

Wikipedia : 73 Cirrhosis, also known as liver cirrhosis or hepatic cirrhosis, and end-stage liver disease, is the... more...

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Related Diseases for Alcoholic Liver Cirrhosis

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Diseases related to Alcoholic Liver Cirrhosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 685)
# Related Disease Score Top Affiliating Genes
1 varicose veins 31.4 TNF IL6 F2 CXCL8
2 peritonitis 30.9 TNF IL6 F2 CXCL8 ALB
3 purpura 30.8 TNF IL6 F2
4 pancreatitis 30.8 TNF IL6 CYP2E1 ALDH2 ADH1C ADH1B
5 alcoholic pancreatitis 30.8 GSTM1 CYP2E1 ALDH2 ADH1C ADH1B
6 alcoholic cardiomyopathy 30.8 CYP2E1 ALDH2 ADH1B
7 antipyrine metabolism 30.6 F2 ALB
8 alcohol dependence 30.6 TNF CYP2E1 ALDH2 AKR1A1 ADH4 ADH1C
9 meningitis 30.6 TNF IL6 CXCL8 ALB
10 hepatorenal syndrome 30.6 GPT F2 ALB
11 end stage renal disease 30.5 TNF SOD2 IL6 ALB
12 fasciitis 30.5 TNF IL6 CXCL8
13 infective endocarditis 30.5 TNF IL6 F2
14 esophageal varix 30.5 GPT F2 ALB AFP
15 necrotizing fasciitis 30.5 IL6 CXCL8 ALB
16 hepatic encephalopathy 30.4 TNF IL6 GPT F2 ALB
17 toxic shock syndrome 30.4 TNF IL6 CXCL8
18 rosacea 30.4 TNF IL6 GSTM1 CXCL8
19 hepatic coma 30.4 GPT F2 ALB AFP
20 uremia 30.4 TNF IL6 ALB AHSG
21 pericarditis 30.3 TNF IL6 CXCL8 ALB
22 gastroenteritis 30.3 TNF IL6 CXCL8 ALB
23 nephrotic syndrome 30.3 TNF TF IL6 F2 ALB
24 neonatal jaundice 30.3 TNF IL6 GSTM1
25 portal hypertension 30.3 TNF PNPLA3 GPT F2 CXCL8 ALB
26 budd-chiari syndrome 30.3 F2 ALB AFP
27 gastric ulcer 30.3 TNF IL6 HGF CXCL8
28 amebiasis 30.3 TNF CXCL8 ALB
29 bone resorption disease 30.3 TNF IL6 ALB
30 pulmonary disease, chronic obstructive 30.2 TNF IL6 GSTM1 CXCL8 ALB
31 thrombocytosis 30.2 IL6 F2 ALB
32 duodenal ulcer 30.2 TNF IL6 CXCL8
33 endocarditis 30.2 TNF IL6 F2 CXCL8 ALB
34 pneumonia 30.2 TNF IL6 CXCL8 ALB
35 fatty liver disease 30.2 TNF PNPLA3 IL6 GPT CYP2E1 CXCL8
36 pulmonary hypertension 30.1 TNF IL6 F2 CXCL8 ALB
37 proteasome-associated autoinflammatory syndrome 1 30.1 TNF IL6 CXCL8 ALB
38 optic nerve disease 30.1 TNF SOD2 IL6 ALB
39 alcohol use disorder 30.1 TF GPT CYP2E1 ALDH2 ALB AKR1A1
40 pulmonary edema 30.1 TNF F2 CXCL8
41 atherosclerosis susceptibility 30.1 TNF IL6 CXCL8 ALB
42 cerebrovascular disease 30.1 TNF IL6 GSTM1 F2
43 kidney disease 30.0 TNF TF IL6 HGF ALB AHSG
44 hemosiderosis 30.0 TF GPT ALB
45 nutritional deficiency disease 30.0 TF IL6 F2 ALB
46 cholecystitis 30.0 GPT F2 ALB
47 stroke, ischemic 30.0 TNF SOD2 IL6 F2 ALB
48 pulmonary fibrosis, idiopathic 29.9 TNF IL6 HGF CXCL8 ALB
49 glucose intolerance 29.9 TNF IL6 GPT ALB
50 disseminated intravascular coagulation 29.8 TNF IL6 GPT F2

Comorbidity relations with Alcoholic Liver Cirrhosis via Phenotypic Disease Network (PDN): (show all 26)


Acquired Thrombocytopenia Active Peptic Ulcer Disease
Acute Cystitis Acute Kidney Failure
Acute Pancreatitis Alcohol Use Disorder
Alcoholic Cardiomyopathy Alcoholic Gastritis
Alcoholic Hepatitis Alcoholic Neuropathy
Chronic Congestive Splenomegaly Chronic Kidney Disease
Deficiency Anemia Esophageal Varix
Familial Atrial Fibrillation Fatty Liver Disease
Heart Disease Hepatic Encephalopathy
Hepatocellular Carcinoma Hepatorenal Syndrome
Hypersplenism Iron Deficiency Anemia
Portal Hypertension Protein-Energy Malnutrition
Respiratory Failure Urea Cycle Disorder

Graphical network of the top 20 diseases related to Alcoholic Liver Cirrhosis:



Diseases related to Alcoholic Liver Cirrhosis
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Symptoms & Phenotypes for Alcoholic Liver Cirrhosis

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UMLS symptoms related to Alcoholic Liver Cirrhosis:


icterus

MGI Mouse Phenotypes related to Alcoholic Liver Cirrhosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.81 AFP ALB ALDH2 CYP2E1 HGF IL6
2 neoplasm MP:0002006 9.5 AFP ALB ALDH2 CYP2E1 IL6 SOD2
3 skeleton MP:0005390 9.32 AHSG AKR1A1 ALDH2 CYP2E1 F2 GPT
Sources

Drugs & Therapeutics for Alcoholic Liver Cirrhosis

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Drugs for Alcoholic Liver Cirrhosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 72)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Losartan Approved Phase 4 114798-26-4 3961
2
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198
3
Propranolol Approved, Investigational Phase 4 525-66-6 4946
4
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
5 Angiotensin Receptor Antagonists Phase 4
6 Giapreza Phase 4
7 Angiotensinogen Phase 4
8 Angiotensin II Type 1 Receptor Blockers Phase 4
9 Anti-Arrhythmia Agents Phase 4
10 Antihypertensive Agents Phase 4
11 Neurotransmitter Agents Phase 4
12 Adrenergic Antagonists Phase 4
13 Adrenergic beta-Antagonists Phase 4
14 Mineralocorticoid Receptor Antagonists Phase 4
15 Hormone Antagonists Phase 4
16 Diuretics, Potassium Sparing Phase 4
17 Hormones Phase 4
18 Mineralocorticoids Phase 4
19 Vasodilator Agents Phase 4
20 Adrenergic Agents Phase 4
21 diuretics Phase 4
22
tannic acid Approved Phase 3 1401-55-4
23
Iron Approved Phase 3 7439-89-6 23925 29936
24
Benzocaine Approved, Investigational Phase 3 1994-09-7, 94-09-7 2337
25 Liver Extracts Phase 3
26
Caffeine Approved Phase 2 58-08-2 2519
27
Baclofen Approved Phase 1, Phase 2 1134-47-0 2284
28 GABA Agonists Phase 1, Phase 2
29
Ritonavir Approved, Investigational Phase 1 155213-67-5 392622
30
Ribavirin Approved Phase 1 36791-04-5 37542
31
Peginterferon alfa-2a Approved, Investigational Phase 1 198153-51-4 5360545
32
Tipranavir Approved, Investigational Phase 1 174484-41-4 65027
33 Cytochrome P-450 CYP3A Inhibitors Phase 1
34 Antimetabolites Phase 1
35 interferons Phase 1
36 Anti-HIV Agents Phase 1
37 Anti-Infective Agents Phase 1
38 Anti-Retroviral Agents Phase 1
39 Antiviral Agents Phase 1
40 HIV Protease Inhibitors Phase 1
41 Interferon-alpha Phase 1
42 Interferon alpha-2 Phase 1
43
protease inhibitors Phase 1
44 Cytochrome P-450 Enzyme Inhibitors Phase 1
45 Iron-Dextran Complex Phase 1
46 Anesthetics Phase 1
47
Zinc Approved, Investigational 7440-66-6 32051
48
Zinc sulfate Approved, Investigational 7733-02-0
49
Lactulose Approved 4618-18-2 11333
50
Furosemide Approved, Vet_approved 54-31-9 3440

Interventional clinical trials:

(show all 30)
# Name Status NCT ID Phase Drugs
1 Losartan in the Prevention of Sodium Retention and Ascites in Liver Cirrhosis - a Prospective Randomized Long-Term Study Unknown status NCT00239096 Phase 4 losartan (drug)
2 Hemodynamic Effects of Chronic Administration of Spironolactone, Propranolol and Their Association in Alcoholic Cirrhotic Patients Terminated NCT00188045 Phase 4 Propranolol - Spironolactone
3 A Multicenter, Randomized, Open-label Phase III Clinical Trial to Evaluate Efficacy and Safety of the Cellgram-LC in Patients With Alcoholic Liver Cirrhosis Not yet recruiting NCT04689152 Phase 3
4 Influence of Iron Depletion by Phlebotomy on the Risk of Hepatocellular Carcinoma Occurrence in Patients With Compensated Alcoholic Cirrhosis. Prospective, Multicentre, Randomized Trial Terminated NCT01342705 Phase 3
5 The Evaluation of Effectiveness and Safety for New Therapy With Bone Marrow Derived Autologous Mesenchymal Stem Cell for Hepatic Failure Caused by Alcoholic Liver Cirrhosis Unknown status NCT01741090 Phase 2
6 A Parallel Group Randomized Open Blinded End Point Evaluation, Multicentric, Dose Escalation, Phase -II Study Assessing the Safety and Efficacy of Intraarterial (Hepatic) Ex-vivo Cultured Adult Allogenic Mesenchymal Stem Cells in Patients With Alcoholic Liver Cirrhosis Completed NCT01591200 Phase 2
7 Randomized Exploratory Clinical Trial to Evaluate the Safety and Effectiveness of Stem Cell Product in Alcoholic Liver Cirrhosis Patient. Completed NCT01875081 Phase 2
8 Maintaining Alcohol Abstinence in Alcoholic Patients With Liver Cirrhosis: Efficacy and Safety of Baclofen Administration in a Randomized Double Blind Controlled Study Completed NCT00525252 Phase 1, Phase 2 Baclofen;placebo
9 Open Label, Study to Determine the Pharmacokinetic Interactions of Steady State Tipranavir/Ritonavir (500/200 mg) and Steady State Ribavirin and Pegylated Interferon Alfa 2a in HIV Negative, HCV Infected Subjects With Mild Hepatic Impairment and the Pharmacokinetic Properties of Tipranavir/Ritonavir in HIV Negative, HCV, HBV, Hepatitis Delta Infected Subjects or Alcoholic Cirrhosis Subjects With Moderate Hepatic Impairment Completed NCT02259855 Phase 1 Tipranavir;Ritonavir;Pegylated interferon;Ribavirin
10 A Phase I, Open-Label, Single-Dose Study to Evaluate the Safety and Efficacy of Hepatic Artery Injection of Autologous Human Bone Marrow-Derived Mesenchymal Stem Cells (Cellgramâ„¢) in Patients With Alcoholic Liver Cirrhosis Recruiting NCT03838250 Phase 1
11 Genetical Predisposition in Hepatocellular Carcinoma : Pangenomic Link Study During Alcoholic Cirrhosis Unknown status NCT01065233
12 Long-term Follow-up Study of Livercellgram in Alcoholic Liver Cirrhosis Patients Who Completed Livercellgram Phase 2 Study Completed NCT02806011
13 A Double-Blind, Randomized, Placebo-Controlled Study of the Effects of Daily Oral Zinc Sulfate (220 mg) in Subjects With Alcoholic Cirrhosis Completed NCT02072746
14 Randomized Trial Comparing Liver Transplantation to Alternative Therapies for Patients With Pugh B Alcoholic Cirrhosis Completed NCT00701792
15 A Study of Molecular and Genetic Factors for Liver Cancer in the Greater Baltimore Area Completed NCT00913757
16 Makuuchi Versus Barcelona Clinic of Liver Cancer Criteria in Cirrhotic Patients With Hepatocellular Carcinoma. Does Etiology of Cirrhosis Influence the Relationship Between the Portal Pressure and Quantitative Tests of Liver Function? Completed NCT00827723
17 Randomised Open-label Multicenter Study Evaluating Ciprofloxacin in Severe Alcoholic Hepatitis in Addition to Prednisolon Therapy Completed NCT02326103 Early Phase 1 Ciprofloxacin;Placebo
18 Adipose Tissue Involvement in Alcohol-induced Liver Inflammation in Human : Study of Pro- and Anti-inflammatory Cytokines and ADIPOKINES.. Completed NCT00388323
19 Validation of an Accelerated Procedure of Selection in Early Liver Transplantation for Severe Alcoholic Hepatitis Not Responding to Medical Treatment QuickTransHAA. Completed NCT01756794
20 Study of Genetic Determinants in Alcoholic Hepatitis and Establishment of a Multicenter Prospective Cohort of Patients With Alcoholic Liver Disease Recruiting NCT04106518
21 EUS Based Prevalence of Chronic Pancreatitis in Alcoholic Cirrhosis: Any Difference Between Alcoholic and Non-alcoholic Patients Recruiting NCT04245189
22 Prognostic Value of Liver Volume on Acute Decompensation of Alcoholic Cirrhosis, a Prospective Multicenter Observational Study Recruiting NCT03508388
23 Phenotypical and Pathophysiological Characterization of Patients With Alcohol-related Liver Disease Recruiting NCT04363424
24 A Randomized, Pragmatic, Outcome-assessor-blinded Study of an SMS-message-based Lifestyle Intervention in Patients With Decompensated Liver Cirrhosis Recruiting NCT02811887
25 Copenhagen Liver Cohort Study: Disease Characteristics, Outcomes and Rehabilitation in Liver Cirrhosis - A Prospective Cohort Study Recruiting NCT04422223
26 Mild Hypothermia and Acute Kidney Injury in Liver Transplantation (MHALT) Trial Recruiting NCT03534141
27 Profermin®: Prevention of Progression in Alcoholic Liver Disease by Modulating Dysbiotic Microbiota - a Randomized Controlled Clinical Trial Recruiting NCT03863730
28 CIRRAL: Hepatocellular Carcinoma in Patients With Uncomplicated Alcoholic Cirrhosis: Incidence and Predictive Factors. A Multicentric Prospective Cohort Active, not recruiting NCT01213927
29 A Multi-center, Randomized, Placebo-controlled Trial of S-Adenosylmethionine (SAMe) in Patients With Alcoholic Cirrhosis Not yet recruiting NCT04250259
30 Early Detection of Advanced Liver Fibrosis in Patients With Excessive Alcohol Intake Not yet recruiting NCT04070508

Search NIH Clinical Center for Alcoholic Liver Cirrhosis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Alcoholic Liver Cirrhosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Alcoholic Liver Cirrhosis:
Livercellgram, bone marrow-derived mesenchymal stem cells for treatment of alcoholic liver cirrhosis
Embryonic/Adult Cultured Cells Related to Alcoholic Liver Cirrhosis:
Bone marrow-derived mesenchymal stem cells

Cochrane evidence based reviews: liver cirrhosis, alcoholic

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Genetic Tests for Alcoholic Liver Cirrhosis

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Anatomical Context for Alcoholic Liver Cirrhosis

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MalaCards organs/tissues related to Alcoholic Liver Cirrhosis:

40
Liver, Bone, Bone Marrow, Kidney, Heart, Skin, Spleen
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Alcoholic Liver Cirrhosis:
# Tissue Anatomical CompartmentCell Relevance
1 Liver Liver Lobule Hepatocytes Affected by disease
Sources

Publications for Alcoholic Liver Cirrhosis

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Articles related to Alcoholic Liver Cirrhosis:

(show top 50) (show all 1403)
# Title Authors PMID Year
1
Association of polymorphism in alcohol dehydrogenase and interaction with other genetic risk factors with alcoholic liver cirrhosis. 61 54
20171022 2010
2
Polymorphism in cytochrome P450 2E1 and interaction with other genetic risk factors and susceptibility to alcoholic liver cirrhosis. 61 54
19428381 2009
3
Polymorphism in glutathione-S-transferases: a risk factor in alcoholic liver cirrhosis. 61 54
19157724 2009
4
Human serum fetuin A/alpha2HS-glycoprotein level is associated with long-term survival in patients with alcoholic liver cirrhosis, comparison with the Child-Pugh and MELD scores. 61 54
17394649 2007
5
[Serum cytokine concentration as prognostic factor in patients with alcoholic liver disease]. 54 61
17036498 2006
6
[Genetic polymorphisms of alcohol-metabolizing enzymes and cytokines in patients with alcohol induced pancreatitis and alcoholic liver cirrhosis]. 61 54
15220553 2004
7
New concepts of the pathogenesis of alcoholic liver disease lead to novel treatments. 54 61
14720455 2004
8
[Effects of genetic polymorphisms of ethanol-metabolizing enzymes on alcohol drinking behaviors]. 54 61
12824748 2003
9
[Studies on the mechanism of elevation of serum PIVKA-II levels in alcoholic liver cirrhosis]. 54 61
11985059 2002
10
Serum leptin levels in alcoholic liver cirrhosis: relationship with gender, nutritional status, liver function and energy metabolism. 54 61
11641747 2001
11
Hepatitis C and the leptin system: bound leptin levels are elevated in patients with hepatitis C and decrease during antiviral therapy. 61 54
11336170 2001
12
Serum cytokine levels in alcohol-related liver cirrhosis. 61 54
11282449 2001
13
Alcohol-related cirrhosis with pancreatitis. The role of oxidative stress in the progression of the disease. 61 54
11348018 2001
14
Serum levels of cytokines in alcoholic liver cirrhosis and pancreatitis. 54 61
11059648 2000
15
N-acetyltransferase-2, glutathione S-transferase M1, alcohol dehydrogenase, and cytochrome P450IIE1 genotypes in alcoholic liver cirrhosis: a case-control study. 54 61
10232877 1999
16
[Liver function and the level of total cholesterol in the blood serum in liver cirrhosis]. 61 54
10204356 1998
17
Oxidative stress in the liver and biliary tract diseases. 54 61
9867111 1998
18
Plasminogen in patients with liver cirrhosis. 54 61
9253235 1997
19
Plasma glutathione S-transferase alpha 1-1 levels in patients with chronic liver disorders. 54 61
9049444 1997
20
Polymorphisms in alcohol metabolizing enzyme genes and alcoholic cirrhosis in Japanese patients: a multivariate analysis. 61 54
7557863 1995
21
Altered expression of monocyte IgA Fc receptors is associated with defective endocytosis in patients with alcoholic cirrhosis. Potential role for IFN-gamma. 54 61
7636220 1995
22
Genotypes of alcohol-metabolizing enzymes in Mexicans with alcoholic liver cirrhosis. 54 61
8845660 1995
23
[Blood chemistry, hematology of patients with liver cirrhosis]. 54 61
8114309 1994
24
Erythrocyte antioxidant activity, serum ceruloplasmin, and trace element levels in subjects with alcoholic liver disease. 54 61
1575205 1992
25
[Membrane cholesterol and insulin receptor in erythrocytes]. 54 61
1774014 1991
26
COVID-19 in a Patient with Liver Cirrhosis. 61
33686051 2021
27
Incidence and management patterns of alcohol-related liver disease in Korea: a nationwide standard cohort study. 61
33758281 2021
28
The role of alcohol use in the aetiology and progression of liver disease: A narrative review and a quantification. 61
33783063 2021
29
Analysis of Risk Factors Affecting Incidence of Osteoporosis and Fragility Fractures in Liver Transplant Recipients. 61
33542170 2021
30
Treatment profile and long-term outcome of intensive care unit-admitted patients with liver cirrhosis or other liver disease in relation to alcohol consumption. 61
33332198 2021
31
COVID-19 risk, disparities and outcomes in patients with chronic liver disease in the United States. 61
33521611 2021
32
PNPLA3 rs738409 associates with alcoholic liver cirrhosis but not with serum levels of IL6, IL10, IL8 or CCL2 in the Russian population. 61
32871288 2021
33
Plateletcrit and Mean Platelet Volume in the Evaluation of Alcoholic Liver Cirrhosis and Nonalcoholic Fatty Liver Disease Patients. 61
33644233 2021
34
Serum Concentration of Fluoride in Patients with Alcoholic Liver Cirrhosis from the Lublin Region in Eastern Poland. 61
33513857 2021
35
Proprotein convertase subtilisin/kexin type 9 (PCSK9) levels are not associated with severity of liver disease and are inversely related to cholesterol in a cohort of thirty eight patients with liver cirrhosis. 61
33461570 2021
36
[Four cases of alcoholic liver cirrhosis in alcohol-dependent patients treated with nalmefene]. 61
33431755 2021
37
Management options for rectal variceal bleeding in the setting of hepatic encephalopathy. 61
32407000 2021
38
National trends and outcomes of genetically inherited non-alcoholic chronic liver disease in the USA: estimates from the National Inpatient Sample (NIS) database. 61
33747525 2021
39
Evaluation of the Long-term Administration of Rifaximin for More than Three Years in the Treatment of Repeated and Recurrent Overt Hepatic Encephalopathy. 61
33790139 2021
40
Mortality Risk and Decompensation in Hospitalized Patients with Non-Alcoholic Liver Cirrhosis: Implications for Disease Management. 61
33445719 2021
41
Two alcoholic liver cirrhosis patients developed diabetic ketoacidosis after SGLT2 inhibitors-prescription. 61
32690358 2020
42
Towards an evaluation of alcoholic liver cirrhosis and nonalcoholic fatty liver disease patients with hematological scales. 61
33384553 2020
43
Association of fibroblast growth factor 21 with alcohol consumption and alcohol liver cirrhosis. 61
33330965 2020
44
Analysis of novel serum markers of fibrosis and angiogenesis in patients with alcoholic liver cirrhosis. 61
33356062 2020
45
[Laparoscopic Resection of Solitary Lymph Node Metastasis of Hepatocellular Carcinoma after Transcatheter Arterial Chemoembolization and Percutaneous Locoregional Therapies]. 61
33468865 2020
46
Pedunculated esophageal carcinoma endoscopically removed using SB knife Jr with detachable snare after neoadjuvant chemotherapy. 61
32870482 2020
47
Necrotizing Fasciitis Caused by Aeromonas hydrophila With Catastrophic Progression. 61
33325308 2020
48
Refractory CIDP: Clinical characteristics, antibodies and response to alternative treatment. 61
32841917 2020
49
The severity of hepatic disorder is related to vertebral microstructure deterioration in cadaveric donors with liver cirrhosis. 61
33170963 2020
50
The micro-structural analysis of lumbar vertebrae in alcoholic liver cirrhosis. 61
32577771 2020
Sources

Variations for Alcoholic Liver Cirrhosis

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Expression for Alcoholic Liver Cirrhosis

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Search GEO for disease gene expression data for Alcoholic Liver Cirrhosis.
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Pathways for Alcoholic Liver Cirrhosis

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Pathways related to Alcoholic Liver Cirrhosis according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Cytochrome P450 - arranged by substrate type 65
Show member pathways
 13.07 GSTM1 CYP2E1 CYP2A6 ALDH2 AKR1A1 ADH4
2
Pathways in cancer 36
12.76 IL6 HGF GSTM1 F2 CXCL8
3
Glucose metabolism 65
Show member pathways
 12.64 ALDH2 AKR1A1 ADH4 ADH1C ADH1B
4
Drug metabolism - cytochrome P450 36
Show member pathways
 12.6 GSTM1 CYP2E1 CYP2A6 ALDH2 ADH4 ADH1C
5
Selenium Micronutrient Network 1
Show member pathways
 12.24 TNF SOD2 IL6 F2 ALB
6
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.07 TNF TF IL6 CXCL8
7
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.96 IL6 HGF ALB AFP
8
Interleukin-4 and 13 signaling 65
11.88 TNF IL6 HGF CXCL8
9
superpathway of tryptophan utilization 1
Show member pathways
 11.73 CYP2A6 ALDH2 AKR1A1 ADH1B
10
Glucocorticoid receptor regulatory network 1
11.72 IL6 CXCL8 AFP
11
Phenylalanine metabolism 36
Show member pathways
 11.71 ADH4 ADH1C ADH1B
12
Acetaminophen Pathway (therapeutic doses), Pharmacokinetics 60
Show member pathways
 11.7 GSTM1 CYP2E1 CYP2A6
13
Pertussis 36
11.67 TNF IL6 CXCL8
14
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.59 TNF IL6 CXCL8
15
Glycerolipid metabolism 36
11.56 PNPLA3 ALDH2 AKR1A1
16
Legionellosis 36
11.52 TNF IL6 CXCL8
17
Lung fibrosis 1
11.47 TNF IL6 HGF CXCL8
18
Interleukin-10 signaling 65
11.44 TNF IL6 CXCL8
19
Differentiation Pathway 1
11.42 TF IL6 HGF
20
FOXA2 and FOXA3 transcription factor networks 1
11.37 F2 ALB AFP
21
Malaria 36
11.16 TNF IL6 HGF CXCL8
22
Overview of nanoparticle effects 1
10.93 TNF IL6 CXCL8
23
noradrenaline and adrenaline degradation 1
Show member pathways
 10.79 ALDH2 ADH4 ADH1B
24
ethanol degradation II 1
Show member pathways
 10.76 CYP2E1 ALDH2 ADH1B
25
Naphthalene metabolism 23
10.64 GSTM1 CYP2E1 CYP2A6 AKR1A1
26
Cyclophosphamide Pathway, Pharmacodynamics 60
Show member pathways
 10.51 ALDH2 AKR1A1 ADH4 ADH1C ADH1B
27
acetone degradation I (to methylglyoxal) 1
Show member pathways
 10.47 CYP2E1 CYP2A6 ADH1B
28
Benzene metabolism 1
10.36 GSTM1 CYP2E1
Sources

GO Terms for Alcoholic Liver Cirrhosis

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Cellular components related to Alcoholic Liver Cirrhosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 9.46 TF F2 ALB AHSG
2 platelet alpha granule lumen GO:0031093 9.43 HGF ALB AHSG
3 endoplasmic reticulum lumen GO:0005788 9.43 TF IL6 F2 ALB AHSG AFP
4 extracellular space GO:0005615 9.36 TNF TF IL6 HGF GPT F2

Biological processes related to Alcoholic Liver Cirrhosis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.8 TF IL6 ALB AHSG AFP
2 oxidation-reduction process GO:0055114 9.76 SOD2 CYP2E1 CYP2A6 ALDH2 AKR1A1 ADH4
3 retinol metabolic process GO:0042572 9.61 ADH4 ADH1C ADH1B
4 platelet degranulation GO:0002576 9.56 TF HGF ALB AHSG
5 acute-phase response GO:0006953 9.54 IL6 F2 AHSG
6 positive regulation of neuroinflammatory response GO:0150078 9.52 TNF IL6
7 cellular aldehyde metabolic process GO:0006081 9.51 AKR1A1 ADH4
8 positive regulation of JAK-STAT cascade GO:0046427 9.5 TNF IL6 F2
9 negative regulation of lipid storage GO:0010888 9.49 TNF IL6
10 vascular endothelial growth factor production GO:0010573 9.48 TNF IL6
11 alcohol metabolic process GO:0006066 9.46 ALDH2 ADH4
12 cellular protein metabolic process GO:0044267 9.43 TF IL6 F2 ALB AHSG AFP
13 ethanol oxidation GO:0006069 8.92 ALDH2 ADH4 ADH1C ADH1B

Molecular functions related to Alcoholic Liver Cirrhosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.56 SOD2 CYP2E1 CYP2A6 ALDH2 AKR1A1 ADH4
2 oxygen binding GO:0019825 9.43 SOD2 CYP2E1 ALB
3 alditol:NADP+ 1-oxidoreductase activity GO:0004032 9.37 AKR1A1 ADH4
4 alcohol dehydrogenase activity, zinc-dependent GO:0004024 9.33 ADH4 ADH1C ADH1B
5 alcohol dehydrogenase (NAD) activity GO:0004022 9.32 ADH4 ADH1C
6 retinol dehydrogenase activity GO:0004745 8.92 AKR1A1 ADH4 ADH1C ADH1B
Sources

Sources for Alcoholic Liver Cirrhosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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