Alcoholic Liver Cirrhosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ALC009 MIFTS: 57	Alcoholic Liver Cirrhosis Categories: Gastrointestinal diseases, Liver diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Alcoholic Liver Cirrhosis

MalaCards integrated aliases for Alcoholic Liver Cirrhosis:

Name: Alcoholic Liver Cirrhosis ¹¹ ⁷⁵ ¹⁴ ³⁶ ¹⁶ ³³

Alcoholic Cirrhosis ¹¹ ⁵³ ¹⁴ ³³

Portal Cirrhosis ¹¹ ⁵³ ⁷¹

Alcoholic Cirrhosis of Liver ¹¹ ³¹

Liver Cirrhosis, Alcoholic ⁴³ ⁷¹

Laennec's Cirrhosis, Alcoholic ¹¹

Alcoholic Laennec Cirrhosis ³³

Alcohol Hepatic Cirrhosis ³³

Alcoholic Cirrhosis Nos ³³

Alcohol Liver Cirrhosis ³³

Laennec's Cirrhosis ¹¹

Alcohol Cirrhosis ³³

Laennec Cirrhosis ³³

Etoh Cirrhosis ³³

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases Liver diseases

See all MalaCards categories (disease lists)

ICD10: ³¹

Diseases of the digestive system

Diseases of liver

Alcoholic liver disease

Alcoholic cirrhosis of liver

ICD11: ³³

Diseases of the digestive system

Diseases of liver

Alcoholic liver disease

Alcoholic cirrhosis of liver without hepatitis

External Ids:

Disease Ontology ¹¹ DOID:14018

ICD9CM ³⁴ 571.2

MeSH ⁴³ D008104

NCIt ⁴⁹ C34782

SNOMED-CT ⁶⁸ 420054005

ICD10 ³¹ K70.3

EFO ¹⁶ EFO_1000802

ICD11 ³³ 474954105

UMLS ⁷¹ C0023891 C1622502

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Summaries for Alcoholic Liver Cirrhosis

MalaCards based summary: Alcoholic Liver Cirrhosis, also known as alcoholic cirrhosis, is related to alcohol dependence and varicose veins, and has symptoms including icterus An important gene associated with Alcoholic Liver Cirrhosis is CYP2E1 (Cytochrome P450 Family 2 Subfamily E Member 1), and among its related pathways/superpathways are Metabolism and Metapathway biotransformation Phase I and II. The drugs Losartan and Angiotensin II have been mentioned in the context of this disorder. Affiliated tissues include Liver, bone marrow and skin, and related phenotypes are homeostasis/metabolism and neoplasm

Wikipedia: ⁷⁵ Cirrhosis, also known as liver cirrhosis or hepatic cirrhosis, and end-stage liver disease, is the... more...

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Related Diseases for Alcoholic Liver Cirrhosis

Diseases related to Alcoholic Liver Cirrhosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 961)

#	Related Disease	Score	Top Affiliating Genes
1	alcohol dependence	31.4	TNF INS IL1B GPT CYP2E1 ALDH2
2	varicose veins	31.3	TNF IL6 F2 CXCL8
3	liver cirrhosis	31.0	TNF INS IL6 GPT F2 CYP2E1
4	portal hypertension	30.9	TNF GPT F2 ALB AFP
5	hepatic encephalopathy	30.9	TNF IL6 GPT F2 ALB
6	esophageal varix	30.8	INS GPT F2 ALB AFP
7	alcoholic pancreatitis	30.8	GSTM1 CYP2E1 ALDH2 ADH1C ADH1B
8	hepatorenal syndrome	30.7	GPT F2 ALB AFP
9	alcoholic cardiomyopathy	30.7	CYP2E1 ALDH2 ADH1B
10	peritonitis	30.7	TNF IL6 IL1B F2 CXCL8 ALB
11	allergic disease	30.7	TNF IL6 IL1B CXCL8
12	vasculitis	30.7	TNF IL6 IL1B CXCL8
13	toxic shock syndrome	30.7	TNF IL6 IL1B CXCL8
14	gastritis	30.7	TNF IL6 IL1B CXCL8
15	henoch-schoenlein purpura	30.6	TNF IL6 ALB
16	purpura	30.6	TNF IL6 IL1B F2 CXCL8
17	nutritional deficiency disease	30.6	IL6 F2 ALB
18	alcoholic neuropathy	30.6	TNF IL1B ALDH2
19	mucormycosis	30.6	TNF INS IL6
20	viral infectious disease	30.5	TNF IL6 IL1B GPT CXCL8
21	fasciitis	30.5	TNF IL6 CXCL8
22	vitamin k deficiency bleeding	30.5	F2 AHSG AFP
23	crohn's colitis	30.5	TNF IL6 IL1B
24	viral hepatitis	30.5	IL6 GPT F2 ALB AFP
25	meningitis	30.4	TNF IL6 IL1B CXCL8 ALB
26	splenic tuberculosis	30.4	TNF F2 ALB
27	inflammatory bowel disease 1	30.4	TNF IL6 IL1B
28	poliomyelitis	30.4	TNF IL6 ALB
29	back pain	30.4	IL6 IL1B CXCL8
30	non-alcoholic fatty liver disease	30.4	TNF INS IL6 IL1B GPT CYP2E1
31	liver disease	30.4	TNF INS IL6 GPT F2 CYP2E1
32	periodontitis	30.3	TNF IL6 IL1B CXCL8
33	hepatocellular adenoma	30.3	GSTP1 GSTM1 AFP
34	tobacco addiction	30.3	GSTP1 GSTM1 CYP2E1 ALDH2 ADH1B
35	cholecystitis	30.3	GPT F2 ALB
36	angina pectoris	30.3	TNF INS IL6
37	amyloidosis	30.3	TNF INS IL6 IL1B ALB
38	pericarditis	30.3	TNF IL6 IL1B CXCL8
39	choledocholithiasis	30.3	GPT F2 ALB
40	budd-chiari syndrome	30.3	GPT F2 ALB AFP
41	duodenal ulcer	30.3	TNF INS IL6 IL1B CXCL8
42	alcoholic hepatitis	30.3	TNF IL6 IL1B GPT F2 CYP2E1
43	hypersensitivity vasculitis	30.3	TNF IL6 F2 ALB
44	aspergillosis	30.3	TNF IL6 IL1B CXCL8
45	spondylitis	30.3	TNF IL6 IL1B
46	rubella	30.3	TNF IL6 IL1B GPT
47	nephrotic syndrome	30.3	TNF INS IL6 IL1B F2 ALB
48	adult syndrome	30.3	TNF INS IL6 GAPDH
49	infective endocarditis	30.3	IL6 F2 CXCL8 ALB
50	rosacea	30.3	TNF IL6 IL1B GSTM1 CXCL8

Comorbidity relations with Alcoholic Liver Cirrhosis via Phenotypic Disease Network (PDN): (show all 26)

Graphical network of the top 20 diseases related to Alcoholic Liver Cirrhosis:

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Symptoms & Phenotypes for Alcoholic Liver Cirrhosis

UMLS symptoms related to Alcoholic Liver Cirrhosis:

icterus

GenomeRNAi Phenotypes related to Alcoholic Liver Cirrhosis according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	no effect	GR00402-S-1	10.17	ADH1B ADH1C AFP AHSG AKR1A1 ALB
2	no effect	GR00402-S-2	10.17	ADH1B ADH1C AHSG ALB ALDH2 CYP2E1

MGI Mouse Phenotypes related to Alcoholic Liver Cirrhosis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.09	ADH1B ADH1C AFP AHSG AKR1A1 ALB
2	neoplasm	MP:0002006	10.02	AFP ALB ALDH2 CYP2E1 GSTP1 IL1B
3	liver/biliary system	MP:0005370	9.96	AFP ALB ALDH2 CYP2E1 GAPDH IL6
4	muscle	MP:0005369	9.92	AHSG ALB ALDH2 F2 IL6 INS
5	growth/size/body region	MP:0005378	9.83	ADH1B ADH1C AHSG AKR1A1 ALDH2 CYP2E1
6	skeleton	MP:0005390	9.32	AHSG AKR1A1 ALDH2 CYP2E1 F2 GPT

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Drugs & Therapeutics for Alcoholic Liver Cirrhosis

Drugs for Alcoholic Liver Cirrhosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 72)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Losartan

Approved

Phase 4

114798-26-4

3961

Angiotensin II

Approved, Investigational

Phase 4

68521-88-0, 11128-99-7, 4474-91-3

172198

Spironolactone

Approved

Phase 4

1952-01-7, 52-01-7

5833

Propranolol

Approved, Investigational

Phase 4

318-98-9, 525-66-6

62882 4946

Angiotensinogen

Phase 4

16133225

Angiotensin Receptor Antagonists

Phase 4

Angiotensin II Type 1 Receptor Blockers

Phase 4

Giapreza

Phase 4

Anti-Arrhythmia Agents

Phase 4

Antihypertensive Agents

Phase 4

Neurotransmitter Agents

Phase 4

Adrenergic beta-Antagonists

Phase 4

Adrenergic Antagonists

Phase 4

Adrenergic Agents

Phase 4

Hormones

Phase 4

Vasodilator Agents

Phase 4

Hormone Antagonists

Phase 4

Diuretics, Potassium Sparing

Phase 4

diuretics

Phase 4

Mineralocorticoids

Phase 4

Mineralocorticoid Receptor Antagonists

Phase 4

Iron

Approved

Phase 3

7439-89-6

29936

Benzocaine

Approved, Investigational

Phase 3

1994-09-7, 94-09-7

2337

Tannic acid

Approved

Phase 3

1401-55-4

16129878 16129778

Caffeine

Approved

Phase 2

58-08-2

2519

Baclofen

Approved

Phase 1, Phase 2

1134-47-0

2284

GABA Agonists

Phase 1, Phase 2

Ritonavir

Approved, Investigational

Phase 1

155213-67-5

392622

Peginterferon alfa-2a

Approved, Investigational

Phase 1

198153-51-4

Ribavirin

Approved

Phase 1

36791-04-5

37542

Tipranavir

Approved, Investigational

Phase 1

174484-41-4

65027 54682461

Interferon alpha-2

Phase 1

Antiviral Agents

Phase 1

Anti-Retroviral Agents

Phase 1

Anti-Infective Agents

Phase 1

Iron-Dextran Complex

Phase 1

Antimetabolites

Phase 1

interferons

Phase 1

Anti-HIV Agents

Phase 1

Interferon-alpha

Phase 1

HIV Protease Inhibitors

Phase 1

Cytochrome P-450 Enzyme Inhibitors

Phase 1

Cytochrome P-450 CYP3A Inhibitors

Phase 1

protease inhibitors

Phase 1

Zinc cation

Approved, Experimental, Investigational

7440-66-6, 23713-49-7

32051

Zinc sulfate

Approved, Investigational

7733-02-0

Lactulose

Approved

4618-18-2

11333

Furosemide

Approved, Vet_approved

54-31-9

3440

Norfloxacin

Approved

70458-96-7

4539

Ciprofloxacin

Approved, Investigational

Early Phase 1

85721-33-1, 93107-08-5

2764

Interventional clinical trials:

(show all 32)

#	Name	Status	NCT ID	Phase	Drugs
1	Losartan in the Prevention of Sodium Retention and Ascites in Liver Cirrhosis - a Prospective Randomized Long-Term Study	Unknown status	NCT00239096	Phase 4	losartan (drug)
2	Hemodynamic Effects of Chronic Administration of Spironolactone, Propranolol and Their Association in Alcoholic Cirrhotic Patients	Terminated	NCT00188045	Phase 4	Propranolol - Spironolactone
3	A Multicenter, Randomized, Open-label Phase III Clinical Trial to Evaluate Efficacy and Safety of the Cellgram-LC in Patients With Alcoholic Liver Cirrhosis	Recruiting	NCT04689152	Phase 3
4	Influence of Iron Depletion by Phlebotomy on the Risk of Hepatocellular Carcinoma Occurrence in Patients With Compensated Alcoholic Cirrhosis. Prospective, Multicentre, Randomized Trial	Terminated	NCT01342705	Phase 3
5	The Evaluation of Effectiveness and Safety for New Therapy With Bone Marrow Derived Autologous Mesenchymal Stem Cell for Hepatic Failure Caused by Alcoholic Liver Cirrhosis	Unknown status	NCT01741090	Phase 2
6	Randomized Exploratory Clinical Trial to Evaluate the Safety and Effectiveness of Stem Cell Product in Alcoholic Liver Cirrhosis Patient.	Completed	NCT01875081	Phase 2
7	A Parallel Group Randomized Open Blinded End Point Evaluation, Multicentric, Dose Escalation, Phase -II Study Assessing the Safety and Efficacy of Intraarterial (Hepatic) Ex-vivo Cultured Adult Allogenic Mesenchymal Stem Cells in Patients With Alcoholic Liver Cirrhosis	Completed	NCT01591200	Phase 2
8	Maintaining Alcohol Abstinence in Alcoholic Patients With Liver Cirrhosis: Efficacy and Safety of Baclofen Administration in a Randomized Double Blind Controlled Study	Completed	NCT00525252	Phase 1, Phase 2	Baclofen;placebo
9	A Phase I, Open-Label, Single-Dose Study to Evaluate the Safety and Efficacy of Hepatic Artery Injection of Autologous Human Bone Marrow-Derived Mesenchymal Stem Cells (Cellgram™) in Patients With Alcoholic Liver Cirrhosis	Unknown status	NCT03838250	Phase 1
10	Open Label, Study to Determine the Pharmacokinetic Interactions of Steady State Tipranavir/Ritonavir (500/200 mg) and Steady State Ribavirin and Pegylated Interferon Alfa 2a in HIV Negative, HCV Infected Subjects With Mild Hepatic Impairment and the Pharmacokinetic Properties of Tipranavir/Ritonavir in HIV Negative, HCV, HBV, Hepatitis Delta Infected Subjects or Alcoholic Cirrhosis Subjects With Moderate Hepatic Impairment	Completed	NCT02259855	Phase 1	Tipranavir;Ritonavir;Pegylated interferon;Ribavirin
11	A Pilot Clinical Study to Evaluate Safety, Tolerability and Preliminary Efficacy of Intravenous Infusion of Umbilical Cord Mesenchymal Stem Cell in the Treatment of Decompensated Alcoholic Cirrhosis	Recruiting	NCT05155657	Phase 1
12	Prognostic Value of Liver Volume on Acute Decompensation of Alcoholic Cirrhosis, a Prospective Multicenter Observational Study	Unknown status	NCT03508388
13	CIRRAL: Hepatocellular Carcinoma in Patients With Uncomplicated Alcoholic Cirrhosis: Incidence and Predictive Factors. A Multicentric Prospective Cohort	Unknown status	NCT01213927
14	Phenotypical and Pathophysiological Characterization of Patients With Alcohol-related Liver Disease	Unknown status	NCT04363424
15	Long-term Follow-up Study of Livercellgram in Alcoholic Liver Cirrhosis Patients Who Completed Livercellgram Phase 2 Study	Completed	NCT02806011
16	A Double-Blind, Randomized, Placebo-Controlled Study of the Effects of Daily Oral Zinc Sulfate (220 mg) in Subjects With Alcoholic Cirrhosis	Completed	NCT02072746
17	Randomized Trial Comparing Liver Transplantation to Alternative Therapies for Patients With Pugh B Alcoholic Cirrhosis	Completed	NCT00701792
18	Genetical Predisposition in Hepatocellular Carcinoma : Pangenomic Link Study During Alcoholic Cirrhosis	Completed	NCT01065233
19	Adipose Tissue Involvement in Alcohol-induced Liver Inflammation in Human : Study of Pro- and Anti-inflammatory Cytokines and ADIPOKINES..	Completed	NCT00388323
20	Makuuchi Versus Barcelona Clinic of Liver Cancer Criteria in Cirrhotic Patients With Hepatocellular Carcinoma. Does Etiology of Cirrhosis Influence the Relationship Between the Portal Pressure and Quantitative Tests of Liver Function?	Completed	NCT00827723
21	Randomised Open-label Multicenter Study Evaluating Ciprofloxacin in Severe Alcoholic Hepatitis in Addition to Prednisolon Therapy	Completed	NCT02326103	Early Phase 1	Ciprofloxacin;Placebo
22	Validation of an Accelerated Procedure of Selection in Early Liver Transplantation for Severe Alcoholic Hepatitis Not Responding to Medical Treatment QuickTransHAA.	Completed	NCT01756794
23	A Study of Molecular and Genetic Factors for Liver Cancer in the Greater Baltimore Area	Completed	NCT00913757
24	Long-term Follow-up of Patients With Alcoholic Liver Cirrhosis Who Had Administered Cellgram-LC in PMC-P-07 Study	Recruiting	NCT05093881
25	A Multi-center, Randomized, Placebo-controlled Trial of S-Adenosylmethionine (SAMe) in Patients With Alcoholic Cirrhosis	Recruiting	NCT04250259
26	EUS Based Prevalence of Chronic Pancreatitis in Alcoholic Cirrhosis: Any Difference Between Alcoholic and Non-alcoholic Patients	Recruiting	NCT04245189
27	Study of Genetic Determinants in Alcoholic Hepatitis and Establishment of a Multicenter Prospective Cohort of Patients With Alcoholic Liver Disease	Recruiting	NCT04106518
28	Mild Hypothermia and Acute Kidney Injury in Liver Transplantation (MHALT) Trial	Recruiting	NCT03534141
29	Copenhagen Liver Cohort Study: Disease Characteristics, Outcomes and Rehabilitation in Liver Cirrhosis - A Prospective Cohort Study	Recruiting	NCT04422223
30	Profermin®: Prevention of Progression in Alcoholic Liver Disease by Modulating Dysbiotic Microbiota - a Randomized Controlled Clinical Trial	Active, not recruiting	NCT03863730
31	Early Detection of Advanced Liver Fibrosis in Patients With Excessive Alcohol Intake	Not yet recruiting	NCT04070508
32	A Randomized, Pragmatic, Outcome-assessor-blinded Study of an SMS-message-based Lifestyle Intervention in Patients With Decompensated Liver Cirrhosis	Terminated	NCT02811887

Search NIH Clinical Center for Alcoholic Liver Cirrhosis

Cell-based therapeutics:

Data from LifeMap, the Embryonic Development and Stem Cells Database

Read about Alcoholic Liver Cirrhosis cell therapies at LifeMap Discovery.

Stem-cell-based therapeutic approaches for Alcoholic Liver Cirrhosis:

Livercellgram, bone marrow-derived mesenchymal stem cells for treatment of alcoholic liver cirrhosis

Embryonic/Adult Cultured Cells Related to Alcoholic Liver Cirrhosis:

Bone marrow-derived mesenchymal stem cells

Cochrane evidence based reviews: liver cirrhosis, alcoholic

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Genetic Tests for Alcoholic Liver Cirrhosis

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Anatomical Context for Alcoholic Liver Cirrhosis

Organs/tissues related to Alcoholic Liver Cirrhosis:

MalaCards : Liver, Bone Marrow, Skin, Bone, Kidney, Smooth Muscle, Monocytes

Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Alcoholic Liver Cirrhosis:

#	Tissue Anatomical CompartmentCell	Relevance
1	Liver Liver Lobule Hepatocytes	Affected by disease

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Publications for Alcoholic Liver Cirrhosis

Articles related to Alcoholic Liver Cirrhosis:

(show top 50) (show all 5030)

#	Title	Authors	PMID	Year
1	Association of polymorphism in alcohol dehydrogenase and interaction with other genetic risk factors with alcoholic liver cirrhosis. ⁵³ ⁶²	Khan AJ...Parmar D	20171022	2010
2	Myeloperoxidase and superoxide dismutase 2 polymorphisms comodulate the risk of hepatocellular carcinoma and death in alcoholic cirrhosis. ⁵³ ⁶²	Nahon P...Beaugrand M	19731237	2009
3	Polymorphism in cytochrome P450 2E1 and interaction with other genetic risk factors and susceptibility to alcoholic liver cirrhosis. ⁵³ ⁶²	Khan AJ...Parmar D	19428381	2009
4	Polymorphism in glutathione-S-transferases: a risk factor in alcoholic liver cirrhosis. ⁵³ ⁶²	Khan AJ...Parmar D	19157724	2009
5	Hepatic ethanol elimination kinetics in patients with cirrhosis. ⁵³ ⁶²	Dam G...Keiding S	19404864	2009
6	Human serum fetuin A/alpha2HS-glycoprotein level is associated with long-term survival in patients with alcoholic liver cirrhosis, comparison with the Child-Pugh and MELD scores. ⁵³ ⁶²	Kalabay L...Fust G	17394649	2007
7	[Serum cytokine concentration as prognostic factor in patients with alcoholic liver disease]. ⁵³ ⁶²	Ciecko-Michalska I...Michalski M	17036498	2006
8	Risk factors for Staphylococcus aureus infection in liver transplant recipients. ⁵³ ⁶²	Bert F...Fantin B	16123951	2005
9	Redox active plasma iron in C282Y/C282Y hemochromatosis. ⁵³ ⁶²	Le Lan C...Brissot P	15671444	2005
10	Genetic dimorphism in superoxide dismutase and susceptibility to alcoholic cirrhosis, hepatocellular carcinoma, and death. ⁵³ ⁶²	Nahon P...Beaugrand M	15765450	2005
11	[Genetic polymorphisms of alcohol-metabolizing enzymes and cytokines in patients with alcohol induced pancreatitis and alcoholic liver cirrhosis]. ⁵³ ⁶²	Kim MS...Lee MS	15220553	2004
12	New concepts of the pathogenesis of alcoholic liver disease lead to novel treatments. ⁵³ ⁶²	Lieber CS	14720455	2004
13	Status of blood antioxidant enzymes in alcoholic cirrhosis. ⁵³ ⁶²	Chari S...Gupta M	14723322	2003
14	[Effects of genetic polymorphisms of ethanol-metabolizing enzymes on alcohol drinking behaviors]. ⁵³ ⁶²	Kee JY...Chae HB	12824748	2003
15	Human fetuin/alpha2HS-glycoprotein level as a novel indicator of liver cell function and short-term mortality in patients with liver cirrhosis and liver cancer. ⁵³ ⁶²	Kalabay L...Fekete B	11943951	2002
16	HFE gene mutations in alcoholic and virus-related cirrhotic patients with hepatocellular carcinoma. ⁵³ ⁶²	Lauret E...Lopez-Larrea C	12003382	2002
17	[Studies on the mechanism of elevation of serum PIVKA-II levels in alcoholic liver cirrhosis]. ⁵³ ⁶²	Sakizono K...Kasakura S	11985059	2002
18	Polymorphism in alcohol-metabolizing enzymes, glutathione S-transferases and apolipoprotein E and susceptibility to alcohol-induced cirrhosis and chronic pancreatitis. ⁵³ ⁶²	Frenzer A...Roberts-Thomson IC	11966948	2002
19	Free radical mechanisms in immune reactions associated with alcoholic liver disease. ⁵³ ⁶²	Albano E	11796198	2002
20	Lipid peroxidation contributes to immune reactions associated with alcoholic liver disease. ⁵³ ⁶²	Mottaran E...Albano E	11755315	2002
21	Association between polymorphisms of ethanol-metabolizing enzymes and susceptibility to alcoholic cirrhosis in a Korean male population. ⁵³ ⁶²	Lee HC...Kim CY	11748356	2001
22	Serum leptin levels in alcoholic liver cirrhosis: relationship with gender, nutritional status, liver function and energy metabolism. ⁵³ ⁶²	Campillo B...Bories PN	11641747	2001
23	Serum iron parameters in patients with alcoholic and chronic cirrhosis and hepatitis. ⁵³ ⁶²	Jurczyk K...Sych Z	11535942	2001
24	Hepatitis C and the leptin system: bound leptin levels are elevated in patients with hepatitis C and decrease during antiviral therapy. ⁵³ ⁶²	Widjaja A...Brabant G	11336170	2001
25	Serum leptin levels in patients with nonalcoholic chronic liver disease. ⁵³ ⁶²	Nakamuta M...Nawata H	11379347	2001
26	Alcohol-related cirrhosis with pancreatitis. The role of oxidative stress in the progression of the disease. ⁵³ ⁶²	Szuster-Ciesielska A...Kandefer-Szerszen M	11348018	2001
27	Serum cytokine levels in alcohol-related liver cirrhosis. ⁵³ ⁶²	Daniluk J...Kandefer-Szerszen M	11282449	2001
28	Cytochromes P450 2A6, 2E1, and 3A and production of protein-aldehyde adducts in the liver of patients with alcoholic and non-alcoholic liver diseases. ⁵³ ⁶²	Niemela O...Pasanen M	11131450	2000
29	[Oxidative stress and antioxidant defense in alcoholic liver disease and chronic hepatitis C]. ⁵³ ⁶²	Par A...Mozsik G	10962902	2000
30	Serum levels of cytokines in alcoholic liver cirrhosis and pancreatitis. ⁵³ ⁶²	Szuster-Ciesielska A...Kandefer-Zerszen M	11059648	2000
31	Oxidative stress in alcoholic liver disease. ⁵³ ⁶²	Nalini G...Narayanan VA	10701300	1999
32	Interleukin-8 and alcoholic liver disease. ⁵³ ⁶²	Huang YS...Lee SD	10418175	1999
33	N-acetyltransferase-2, glutathione S-transferase M1, alcohol dehydrogenase, and cytochrome P450IIE1 genotypes in alcoholic liver cirrhosis: a case-control study. ⁵³ ⁶²	Rodrigo L...Coto E	10232877	1999
34	[Liver function and the level of total cholesterol in the blood serum in liver cirrhosis]. ⁵³ ⁶²	Komorovs'kyi RR	10204356	1998
35	Gender-dependent alterations in serum leptin in alcoholic cirrhosis. ⁵³ ⁶²	McCullough AJ...Kalhan SC	9753498	1998
36	Distinct patterns of chemokine expression are associated with leukocyte recruitment in alcoholic hepatitis and alcoholic cirrhosis. ⁵³ ⁶²	Afford SC...Adams DH	9875144	1998
37	Association studies of polymorphisms of CYP2E1 gene in alcoholics with cirrhosis, antisocial personality, and normal controls. ⁵³ ⁶²	Parsian A...Zhang ZH	9660317	1998
38	[Serum levels of soluble interleukin-2 receptor in alcoholic patients]. ⁵³ ⁶²	Sopena B...Outon A	9608061	1998
39	Oxidative stress in the liver and biliary tract diseases. ⁵³ ⁶²	Feher J...Blazovics A	9867111	1998
40	Plasminogen in patients with liver cirrhosis. ⁵³ ⁶²	Rodriguez Cuartero A	9253235	1997
41	Plasma glutathione S-transferase alpha 1-1 levels in patients with chronic liver disorders. ⁵³ ⁶²	Mulder TP...Jansen JB	9049444	1997
42	T-cell activation, expression of adhesion molecules and response to ethanol in alcoholic cirrhosis. ⁵³ ⁶²	Santos-Perez JL...Gutierrez-Gea F	8803617	1996
43	Deceptive prothrombin and activated partial thromboplastin times in alcoholic cirrhosis. ⁵³ ⁶²	Sirikonda PR...Lazaro EJ	8667440	1996
44	Serum levels of interleukin-8 in alcoholic liver disease: relationship with disease stage, biochemical parameters and survival. ⁵³ ⁶²	Huang YS...Lee SD	8738722	1996
45	Proportion of the GSTM1 0/0 genotype in some Slavic populations and its correlation with cystic fibrosis and some multifactorial diseases. ⁵³ ⁶²	Baranov VS...Kovaleva L	8834254	1996
46	Polymorphisms in alcohol metabolizing enzyme genes and alcoholic cirrhosis in Japanese patients: a multivariate analysis. ⁵³ ⁶²	Yamauchi M...Toda G	7557863	1995
47	Altered expression of monocyte IgA Fc receptors is associated with defective endocytosis in patients with alcoholic cirrhosis. Potential role for IFN-gamma. ⁵³ ⁶²	Silvain C...Monteiro RC	7636220	1995
48	Genotypes of alcohol-metabolizing enzymes in Mexicans with alcoholic liver cirrhosis. ⁵³ ⁶²	Lisker-Yourkowitzky R...Mutchinick-Baringoltz O	8845660	1995
49	Effects of large-volume paracentesis on pulmonary function in patients with tense cirrhotic ascites. ⁵³ ⁶²	Angueira CE...Kadakia SC	7927222	1994
50	[Blood chemistry, hematology of patients with liver cirrhosis]. ⁵³ ⁶²	Kakehashi R...Suzuki S	8114309	1994

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Genes for Alcoholic Liver Cirrhosis

Genes related to Alcoholic Liver Cirrhosis (0 elite genes):

(show all 31)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	CYP2E1	Cytochrome P450 Family 2 Subfamily E Member 1	Protein Coding	23.13	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	19428381 11748356 20171022 (more) 9660317 14720455 11966948 15220553 19157724 11796198
2	ADH1B	Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide	Protein Coding	22.79	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	15220553 8845660 11748356 (more) 11966948 7557863
3	ADH1C	Alcohol Dehydrogenase 1C (Class I), Gamma Polypeptide	Protein Coding	22.15	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	1592339 15220553 11748356 (more) 11966948
4	ALDH2	Aldehyde Dehydrogenase 2 Family Member	Protein Coding	22.08	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	12824748 15220553 8845660 (more) 11748356 11966948
5	ALB	Albumin	Protein Coding	22.06	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	2123913 7678368 8114309 (more) 7927222 11755315 9608061 9253235
6	F2	Coagulation Factor II, Thrombin	Protein Coding	21.96	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	16123951 8667440 9608061 (more) 9253235
7	GSTM1	Glutathione S-Transferase Mu 1	Protein Coding	17.88	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	19157724 20171022 19428381 (more) 8834254 11966948
8	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	17.68	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11282449 8738722 15220553 (more) 9875144 11059648 10418175 8325620 17036498
9	GPT	Glutamic--Pyruvic Transaminase	Protein Coding	17.19	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	10204356 11985059
10	SOD2	Superoxide Dismutase 2	Protein Coding	15.91	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	19731237 15765450 19157724 (more) 2254630
11	AHSG	Alpha 2-HS Glycoprotein	Protein Coding	15.62	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	17394649 11943951
12	AKR1A1	Aldo-Keto Reductase Family 1 Member A1	Protein Coding	14.46	Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	20171022 19404864 1592339 (more) 8325617 10232877
13	AFP	Alpha Fetoprotein	Protein Coding	14.31	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	16784653 18699979 17416468 (more) 20305756
14	TNF	Tumor Necrosis Factor	Protein Coding	14.08	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
15	IL6	Interleukin 6	Protein Coding	13.7	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
16	IL1B	Interleukin 1 Beta	Protein Coding	13.59	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
17	INS	Insulin	Protein Coding	12.91	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
18	PLIN2	Perilipin 2	Protein Coding	12.47	DISEASES inferred ¹⁴ GeneCards inferred via : Summaries (show sections)
19	GAPDH	Glyceraldehyde-3-Phosphate Dehydrogenase	Protein Coding	11.97	DISEASES inferred ¹⁴ GeneCards inferred via : Proteins (show sections)
20	GSTP1	Glutathione S-Transferase Pi 1	Protein Coding	11.72	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
21	FCAR	Fc Alpha Receptor	Protein Coding	11.71	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	7636220
22	IL1A	Interleukin 1 Alpha	Protein Coding	11.66	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
23	HGF	Hepatocyte Growth Factor	Protein Coding	9.26	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	16784653
24	GGT1	Gamma-Glutamyltransferase 1	Protein Coding	8.98	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	1972004
25	HFE	Homeostatic Iron Regulator	Protein Coding	8.87	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	12003382
26	ALDH9A1	Aldehyde Dehydrogenase 9 Family Member A1	Protein Coding	8.56	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	1592339
27	CNP	2',3'-Cyclic Nucleotide 3' Phosphodiesterase	Protein Coding	8.27	GeneCards inferred via : Summaries (show sections)
28	CD58	CD58 Molecule	Protein Coding	7.97	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	8803617
29	CYP2A6	Cytochrome P450 Family 2 Subfamily A Member 6	Protein Coding	7.92	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	11131450
30	LCAT	Lecithin-Cholesterol Acyltransferase	Protein Coding	7.72	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	1774014
31	GABRG2	Gamma-Aminobutyric Acid Type A Receptor Subunit Gamma2	Protein Coding	7.63	GeneCards inferred via : Publications (show sections)

Sources

Variations for Alcoholic Liver Cirrhosis

Sources

Expression for Alcoholic Liver Cirrhosis

Search GEO for disease gene expression data for Alcoholic Liver Cirrhosis.

Sources

Pathways for Alcoholic Liver Cirrhosis

Pathways related to Alcoholic Liver Cirrhosis according to GeneCards Suite gene sharing:

(show all 44)

#	Super pathways	Score	Top Affiliating Genes
1	Metabolism ⁶⁶ Show member pathways Metabolism of lipids ⁶⁶	13.71	ADH1B ADH1C AKR1A1 ALB ALDH2 CYP2E1
2	Metapathway biotransformation Phase I and II ⁷⁴ Show member pathways Acetaminophen metabolism ²² Aflatoxin B1 metabolism ⁷⁴ Artemisinin and Derivatives Pathway, Pharmacokinetics ⁶⁰ Arylamine metabolism ⁷⁴ Benzo(a)pyrene metabolism ⁷⁴ Benzo[a]pyrene metabolism ²² Benzodiazepine Pathway, Pharmacokinetics ⁶⁰ Biological oxidations ⁶⁶ Cannabidiol Pathway, Pharmacokinetics ⁶⁰ Doxepin Pathway, Pharmacokinetics ⁶⁰ Estradiol metabolism ²² Flurbiprofen Pathway, Pharmacokinetics ⁶⁰ Haloperidol Pathway, Pharmacokinetics ⁶⁰ Methylation ⁶⁶ Naproxen Pathway, Pharmacokinetics ⁶⁰ Phase II - Conjugation of compounds ⁶⁶ Phenprocoumon Pathway, Pharmacokinetics ⁶⁰ Sorafenib Pharmacokinetics ⁶⁰ Tamoxifen Pathway, Pharmacokinetics ⁶⁰ Voriconazole Pathway, Pharmacokinetics ⁶⁰	12.94	GSTP1 GSTM1 CYP2E1 ALDH2 AKR1A1 ADH1C
3	Alzheimer's disease and miRNA effects ⁷⁴ Show member pathways Alzheimer's disease ⁷⁴	12.81	TNF INS IL6 IL1B GAPDH
4	Glucose / Energy Metabolism ³	12.51	ADH1B AHSG GAPDH INS SOD2
5	Toll-Like receptor Signaling Pathways ⁶⁵ Show member pathways Inflammasome Activation Pathways ⁶⁵ Nanomaterial-induced inflammasome activation ⁷⁴ NOD-like Receptor Signaling Pathways ⁶⁵ TLR4 signaling and tolerance ⁷⁴ Toll-Like Receptors Pathway ⁶⁴	12.48	TNF IL6 IL1B CXCL8
6	Bacterial infections in CF airways ²² Show member pathways Altered glycosylation of MUC1 in tumor microenvironment ⁷⁴ IL-1 beta-dependent CFTR expression ²² IL1-mediated signaling events ⁶¹ Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²² NTHi-Induced Signaling ⁶⁴ Signal transduction through IL1R ⁷⁴	12.38	TNF IL6 IL1B CXCL8
7	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) ⁶⁶ Show member pathways Post-translational protein phosphorylation ⁶⁶	12.34	IL6 F2 ALB AHSG AFP
8	Toll Comparative Pathway ⁶⁴ Show member pathways IL-1 Pathway ⁶⁴ Immune response MIF in innate immunity response ²² iNOS Signaling ⁶⁴ TLR-TRIF Pathway ⁶⁴	12.29	TNF IL6 IL1B CXCL8
9	Sudden infant death syndrome (SIDS) susceptibility pathways ⁷⁴	12.09	TNF IL6 IL1B GAPDH CXCL8
10	Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers ⁶⁵	12.06	INS IL6 ALB AFP
11	Adipogenesis ⁷⁴	12.05	TNF PLIN2 INS IL6
12	Spinal cord injury ⁷⁴	11.97	TNF IL6 IL1B CXCL8
13	Interleukin-4 and Interleukin-13 signaling ⁶⁶	11.93	TNF IL6 IL1B CXCL8
14	Senescence and autophagy in cancer ⁷⁴	11.91	CXCL8 IL1B IL6 INS
15	Glucocorticoid receptor regulatory network ⁶¹	11.74	AFP CXCL8 IL6
16	Paracetamol ADME ⁶⁶ Show member pathways Acetaminophen Pathway (therapeutic doses), Pharmacokinetics ⁶⁰ Acetaminophen Pathway (toxic doses), Pharmacokinetics ⁶⁰ Acetylation ⁶⁶ Hydralazine Pathway, Pharmacokinetics ⁶⁰ Sulfasalazine, Mesalazine and Sulfapyridine Pathway, Pharmacokinetics ⁶⁰	11.73	GSTP1 GSTM1 CYP2E1
17	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.71	TNF IL6 IL1B
18	Burn wound healing ⁷⁴	11.71	CXCL8 IL1B IL6 TNF
19	miRNAs involvement in the immune response in sepsis ⁷⁴	11.63	TNF IL6 CXCL8
20	IL 10 signaling pathway ⁶⁷	11.63	TNF IL6 IL1B
21	Photodynamic therapy-induced NF-kB survival signaling ⁷⁴ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.62	TNF IL6 IL1B CXCL8
22	Lung fibrosis ⁷⁴	11.61	TNF IL6 IL1B CXCL8
23	ATF-2 transcription factor network ⁶¹	11.59	INS IL6 CXCL8
24	Non-genomic actions of 1,25 dihydroxyvitamin D3 ⁷⁴	11.54	TNF IL6 CXCL8
25	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	11.48	TNF IL6 IL1B
26	Interleukin-10 signaling ⁶⁶	11.43	TNF IL6 IL1B CXCL8
27	ethanol degradation II ⁶¹ Show member pathways acetate conversion to acetyl-CoA ⁶¹ ethanol degradation III ⁶¹ ethanol degradation IV ⁶¹ Fluoroacetic acid toxicity ⁷⁴ L-phenylalanine degradation IV (mammalian, via side chain) ⁶¹ noradrenaline and adrenaline degradation ⁶¹ oxidative ethanol degradation III ⁶¹ putrescine degradation III ⁶¹	11.4	CYP2E1 ALDH2 ADH1B
28	Nonalcoholic fatty liver disease ⁷⁴	11.4	TNF INS IL6 CYP2E1
29	IL-10 Pathway ⁶⁴	11.35	TNF IL6 IL1B
30	FOXA2 and FOXA3 transcription factor networks ⁶¹ Show member pathways FOXA transcription factor networks ⁶¹	11.34	INS F2 ALB AFP
31	Development and heterogeneity of the ILC family ⁷⁴	11.3	TNF IL6 IL1B
32	Cytokines and inflammatory response ⁷⁴	11.24	TNF IL6 IL1B
33	Immune infiltration in pancreatic cancer ⁷⁴	11.21	TNF IL6 CXCL8
34	Ethanol effects on histone modifications ⁷⁴	11.16	ADH1B ADH1C ALDH2 CYP2E1
35	Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway ⁷⁴	11.03	TNF IL6 IL1B CXCL8
36	Overview of nanoparticle effects ⁷⁴	11.02	TNF IL6 CXCL8
37	Cori cycle ⁷⁴	10.95	INS GPT GAPDH
38	Prostaglandin signaling ⁷⁴	10.9	TNF IL6 IL1B CXCL8
39	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	10.77	IL6 IL1B
40	COVID-19 adverse outcome pathway ⁷⁴	10.68	IL6 CXCL8
41	Naphthalene metabolism ²²	10.64	GSTP1 GSTM1 CYP2E1 AKR1A1
42	Cyclophosphamide Pathway, Pharmacodynamics ⁶⁰ Show member pathways Ifosfamide Pathway, Pharmacodynamics ⁶⁰	10.51	GSTP1 ALDH2 AKR1A1 ADH1C ADH1B
43	Benzene metabolism ⁷⁴	10.35	CYP2E1 GSTM1
44	Cells and molecules involved in local acute inflammatory response ⁷⁴ Show member pathways IL8-mediated signaling events ⁶¹	10.2	TNF IL6 CXCL8

Sources

GO Terms for Alcoholic Liver Cirrhosis

Cellular components related to Alcoholic Liver Cirrhosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	endoplasmic reticulum lumen	GO:0005788	9.73	INS IL6 F2 ALB AHSG AFP
2	extracellular space	GO:0005615	9.68	TNF INS IL6 IL1B GSTP1 GPT

Biological processes related to Alcoholic Liver Cirrhosis according to GeneCards Suite gene sharing:

(show all 22)

#	Name	GO ID	Score	Top Affiliating Genes
1	cellular response to lipopolysaccharide	GO:0071222	10.11	TNF IL6 IL1B GSTP1 CXCL8
2	regulation of insulin secretion	GO:0050796	10.08	TNF IL6 IL1B
3	response to activity	GO:0014823	10.08	TNF SOD2 IL6
4	positive regulation of nitric oxide biosynthetic process	GO:0045429	10.06	TNF SOD2 IL1B
5	glutathione metabolic process	GO:0006749	10.05	SOD2 GSTP1 GSTM1
6	positive regulation of receptor signaling pathway via JAK-STAT	GO:0046427	10.02	TNF IL6 F2
7	positive regulation of mitotic nuclear division	GO:0045840	10	TNF INS IL1B
8	positive regulation of chemokine production	GO:0032722	9.99	TNF IL6 IL1B
9	positive regulation of cytokine production	GO:0001819	9.98	TNF INS IL1B GAPDH
10	vasodilation	GO:0042311	9.96	TNF SOD2 INS
11	negative regulation of neurogenesis	GO:0050768	9.95	IL1B IL6 TNF
12	negative regulation of lipid catabolic process	GO:0050995	9.88	IL1B INS TNF
13	positive regulation of fever generation	GO:0031622	9.87	IL1B TNF
14	acute-phase response	GO:0006953	9.86	INS IL6 F2 AHSG
15	positive regulation of glial cell proliferation	GO:0060252	9.85	IL1B IL6 TNF
16	sequestering of triglyceride	GO:0030730	9.84	TNF IL1B
17	positive regulation of calcidiol 1-monooxygenase activity	GO:0060559	9.81	TNF IL1B
18	aldehyde catabolic process	GO:0046185	9.8	ALDH2 AKR1A1
19	positive regulation of neuroinflammatory response	GO:0150078	9.8	TNF IL6 IL1B
20	alcohol metabolic process	GO:0006066	9.46	ALDH2 ADH1C ADH1B
21	vascular endothelial growth factor production	GO:0010573	9.43	TNF IL6 IL1B
22	glutathione derivative biosynthetic process	GO:1901687	9.1	GSTP1 GSTM1 AKR1A1

Molecular functions related to Alcoholic Liver Cirrhosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	fatty acid binding	GO:0005504	9.73	GSTP1 ALB AFP
2	oxygen binding	GO:0019825	9.63	SOD2 CYP2E1 ALB
3	NAD-retinol dehydrogenase activity	GO:0004745	9.35	AKR1A1 ADH1C ADH1B
4	oxidoreductase activity	GO:0016491	9.23	SOD2 GAPDH CYP2E1 ALDH2 AKR1A1 ADH1C