MCID: ALC009
MIFTS: 53

Alcoholic Liver Cirrhosis

Categories: Endocrine diseases, Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Alcoholic Liver Cirrhosis

MalaCards integrated aliases for Alcoholic Liver Cirrhosis:

Name: Alcoholic Liver Cirrhosis 38 12 76 15
Alcoholic Cirrhosis 12 55 15
Portal Cirrhosis 12 55 73
Liver Cirrhosis, Alcoholic 44 73
Laennec's Cirrhosis, Alcoholic 12
Alcoholic Cirrhosis of Liver 12
Laennec's Cirrhosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14018
ICD10 33 K70.3
ICD9CM 35 571.2
MeSH 44 D008104
NCIt 50 C34782
SNOMED-CT 68 75393009

Summaries for Alcoholic Liver Cirrhosis

MalaCards based summary : Alcoholic Liver Cirrhosis, also known as alcoholic cirrhosis, is related to liver cirrhosis and peritonitis, and has symptoms including icterus An important gene associated with Alcoholic Liver Cirrhosis is ADH1B (Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide), and among its related pathways/superpathways are Metabolism and Cytochrome P450 - arranged by substrate type. The drugs Angiotensin II and Losartan have been mentioned in the context of this disorder. Affiliated tissues include Liver, liver and bone, and related phenotype is homeostasis/metabolism.

Wikipedia : 76 Cirrhosis is a condition in which the liver does not function properly due to long-term damage. This... more...

Related Diseases for Alcoholic Liver Cirrhosis

Diseases related to Alcoholic Liver Cirrhosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 188)
# Related Disease Score Top Affiliating Genes
1 liver cirrhosis 30.6 ADH1B ADH1C AFP ALB ALDH2 CYP2E1
2 peritonitis 30.5 ALB CXCL8 F2
3 esophageal varix 30.3 AFP ALB F2
4 hepatic coma 30.1 ALB F2
5 antipyrine metabolism 30.1 ALB F2
6 alcoholic pancreatitis 30.1 ADH1B ALDH2 CYP2E1
7 infantile liver failure syndrome 1 30.1 ALB F2 SLC17A5
8 alcohol abuse 30.0 ALDH2 CYP2E1 SLC17A5 TF
9 schistosomiasis 29.9 ALB F2 GSTM1
10 hepatic encephalopathy 29.8 ALB F2 SLC17A5
11 hepatitis b 29.7 AFP ALB F2 SLC17A5
12 alcoholic hepatitis 29.7 ALB CXCL8 CYP2E1 F2 SLC17A5
13 endocarditis 29.7 ALB CXCL8 F2
14 esophageal cancer 29.6 ADH1B ALB ALDH2 CXCL8 GSTM1
15 alcohol dependence 29.6 ADH1B ADH1C ADH4 ALDH2 CYP2E1
16 viral hepatitis 29.5 AFP ALB F2 SLC17A5
17 obstructive jaundice 29.4 ALB CXCL8 F2 SLC17A5
18 nonalcoholic steatohepatitis 29.4 CYP2E1 F2 PNPLA3 SLC17A5
19 fatty liver disease 29.4 CXCL8 CYP2E1 PNPLA3 SLC17A5
20 liver disease 29.0 AFP ALB CYP2E1 F2 PNPLA3 SLC17A5
21 hepatitis 10.4
22 hepatocellular carcinoma 10.3
23 isoniazid toxicity 10.3 CYP2E1 NAT2
24 colorectal cancer, childhood 10.2 GSTM1 NAT2
25 non-a-e hepatitis 10.2 ALB F2
26 pancreatitis 10.2
27 phenytoin toxicity 10.2 ALB NAT2
28 fournier gangrene 10.2 ALB F2
29 methanol poisoning 10.2 ADH1B ADH1C CYP2E1
30 sister chromatid exchange, frequency of 10.2 ALDH2 CYP2E1 GSTM1
31 abdominal tuberculosis 10.2 ALB F2
32 scabies 10.2 CXCL8 GSTM1
33 hepatic tuberculosis 10.2 ALB F2
34 pyuria 10.2 ALB CXCL8
35 yellow nail syndrome 10.2 ALB TF
36 esophageal disease 10.2 ADH1B ALB ALDH2
37 drug-induced hepatitis 10.2 CYP2E1 GSTM1 NAT2
38 orbital cyst 10.2 F2 TF
39 noma 10.2 ALB CXCL8
40 marasmus 10.2 ALB TF
41 hepatitis c virus 10.1
42 hepatitis c 10.1
43 viral infectious disease 10.1
44 eccrine adenocarcinoma 10.1 AHSG F2
45 haemophilus influenzae 10.1 CXCL8 TF
46 splenic disease 10.1 ALB F2
47 alcoholic neuropathy 10.1 ADH4 ALDH2
48 capillary leak syndrome 10.1 ALB CXCL8
49 inflammatory and toxic neuropathy 10.1 ADH4 ALDH2
50 hepatoid adenocarcinoma 10.1 AFP ALB

Comorbidity relations with Alcoholic Liver Cirrhosis via Phenotypic Disease Network (PDN): (show all 26)


Acquired Thrombocytopenia Active Peptic Ulcer Disease
Acute Cystitis Acute Kidney Failure
Acute Pancreatitis Alcohol Abuse
Alcoholic Cardiomyopathy Alcoholic Gastritis
Alcoholic Hepatitis Alcoholic Neuropathy
Chronic Congestive Splenomegaly Chronic Kidney Failure
Deficiency Anemia Esophageal Varix
Familial Atrial Fibrillation Fatty Liver Disease
Heart Disease Hepatic Encephalopathy
Hepatocellular Carcinoma Hepatorenal Syndrome
Hypersplenism Iron Deficiency Anemia
Portal Hypertension Protein-Energy Malnutrition
Respiratory Failure Urea Cycle Disorder

Graphical network of the top 20 diseases related to Alcoholic Liver Cirrhosis:



Diseases related to Alcoholic Liver Cirrhosis

Symptoms & Phenotypes for Alcoholic Liver Cirrhosis

UMLS symptoms related to Alcoholic Liver Cirrhosis:


icterus

MGI Mouse Phenotypes related to Alcoholic Liver Cirrhosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.36 ADH1C AFP AHSG ALB ALDH2 CYP2E1

Drugs & Therapeutics for Alcoholic Liver Cirrhosis

Drugs for Alcoholic Liver Cirrhosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 98)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Angiotensin II Approved, Investigational Phase 4 11128-99-7, 68521-88-0, 4474-91-3 172198 65143
2
Losartan Approved Phase 4 114798-26-4 3961
3
Propranolol Approved, Investigational Phase 4,Not Applicable 525-66-6 4946
4
Spironolactone Approved Phase 4,Not Applicable 52-01-7, 1952-01-7 5833
5
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
6 Angiotensin Receptor Antagonists Phase 4
7 Angiotensin II Type 1 Receptor Blockers Phase 4
8 Anti-Arrhythmia Agents Phase 4
9 Angiotensinogen Phase 4
10 Liver Extracts Phase 4,Phase 3,Phase 2,Not Applicable
11 Antihypertensive Agents Phase 4
12 Hormones Phase 4,Phase 2
13 Hormone Antagonists Phase 4,Phase 2
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2
15 valine Phase 4
16 leucine Phase 4
17 isoleucine Phase 4
18 Mineralocorticoids Phase 4
19 Adrenergic beta-Antagonists Phase 4
20 Adrenergic Antagonists Phase 4
21 Vasodilator Agents Phase 4
22 Neurotransmitter Agents Phase 4
23 Mineralocorticoid Receptor Antagonists Phase 4
24 Natriuretic Agents Phase 4
25 Adrenergic Agents Phase 4
26 Diuretics, Potassium Sparing Phase 4
27 diuretics Phase 4
28
Everolimus Approved Phase 3 159351-69-6 6442177
29
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
30
Sirolimus Approved, Investigational Phase 3 53123-88-9 46835353 6436030 5284616
31
Tacrolimus Approved, Investigational Phase 3 104987-11-3 445643 439492
32
Ethanol Approved Phase 3,Not Applicable 64-17-5 702
33
Baclofen Approved Phase 3 1134-47-0 2284
34
Cobalt Approved, Experimental Phase 3 7440-48-4 104729
35
Benzocaine Approved, Investigational Phase 3,Not Applicable 94-09-7, 1994-09-7 2337
36 tannic acid Approved Phase 3,Not Applicable
37
Iron Approved Phase 3 7439-89-6 23925
38 Antifungal Agents Phase 3
39 Calcineurin Inhibitors Phase 3
40 Immunologic Factors Phase 3
41 Antibiotics, Antitubercular Phase 3
42 Anti-Infective Agents Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
43 Immunosuppressive Agents Phase 3
44 Anti-Bacterial Agents Phase 3,Phase 2,Early Phase 1
45
Rifaximin Approved, Investigational Phase 2 80621-81-4 6436173
46
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
47
Caffeine Approved Phase 2 58-08-2 2519
48 Antineoplastic Agents, Hormonal Phase 2
49 Nucleic Acid Synthesis Inhibitors Phase 2
50 Rifamycins Phase 2

Interventional clinical trials:

(show all 38)
# Name Status NCT ID Phase Drugs
1 Prevention of Decompensation in Liver Cirrhosis Unknown status NCT00239096 Phase 4 losartan (drug)
2 Sarcopenia Improves the Muscle Mass and Muscle Strength of Patients With Liver Cirrhosis-Child C Recruiting NCT03633279 Phase 4 Branched chain amino acid;Placebo
3 Hemodynamic Effects of Chronic Administration of Spironolactone and/or Propranolol in Alcoholic Cirrhotic Patients Terminated NCT00188045 Phase 4 Propranolol - Spironolactone
4 REnal Function in Liver Transplantation: Everolimus With Calcineurin Inhibitor (CNI)-Sparing sTrategy Unknown status NCT02115113 Phase 3 Everolimus;Everolimus;Tacrolimus
5 Baclofen in the Treatment of Alcohol Dependence With or Without Alcoholic Liver Disease Completed NCT01711125 Phase 3 Baclofen 30mg/day;Baclofen 75mg/day;Placebo
6 Proton Radiotherapy Versus Radiofrequency Ablation for Patients With Medium or Large Hepatocellular Carcinoma Recruiting NCT02640924 Phase 3
7 Phlebotomy and Risk of Hepatocellular Carcinoma in Patients With Compensated Alcoholic Cirrhosis Terminated NCT01342705 Phase 3
8 The Effectiveness and Safety for Mesenchymal Stem Cell for Alcoholic Liver Cirrhosis Unknown status NCT01741090 Phase 2
9 Effects of Rifaximin in Patients With Acute Alcoholic Hepatitis Unknown status NCT02116556 Phase 2 Prednisone;Rifaximin
10 REVIVE(Randomized Exploratory Clinical Trial to Evaluate the Safety and Effectiveness of Stem Cell Product in Alcoholic Liver Cirrhosis Patient) Completed NCT01875081 Phase 2
11 Dose Finding Study to Assess Safety and Efficacy of Stem Cells in Liver Cirrhosis Completed NCT01591200 Phase 2
12 A Phase II, Double-blinded, Randomized, Controlled Study to Evaluate the Efficacy and Safety of Vitalliver in Patients With Decompensated Cirrhosis Completed NCT00562783 Phase 2 Vitaliver;Placebo
13 Pharmacokinetics (PK) of Tipranavir/Ritonavir, Ribavirin, Pegylated Interferon (Peg INF) in Hepatitis C (HCV) Subjects With Mild Hepatic Impairment and in HCV, Hepatitis B (HBV), Hepatitis D Infected Subjects or Alcoholic Cirrhosis With Moderate Hepatic Impairment Completed NCT02259855 Phase 1 Tipranavir;Ritonavir;Pegylated interferon;Ribavirin
14 Pangenomic Study During Alcoholic Cirrhosis Unknown status NCT01065233
15 Measurement of Fibrinogen in Patients With Systemic Inflammatory Response Syndrome (SIRS), Sepsis or Chronicle Liver Disease on Intensive Care Units (ICU) Unknown status NCT01169168
16 Prospective Analysis Of Cardiac Function In Cirrhotic Patients By Echocardiography And Its Correlation With Events Unknown status NCT01433848
17 FGL2/Fibroleukin and Hepatitis C Virus Recurrence Post Liver Transplantation Unknown status NCT00701272
18 Liver Transplantation Versus Alternative Therapies for Patients With Pugh B Alcoholic Cirrhosis Completed NCT00701792 Not Applicable
19 Adipose Tissue Involvement in Alcohol-induced Liver Inflammation in Human Completed NCT00388323 Not Applicable
20 Randomised Open-label Multicenter Study Evaluating Ciprofloxacin in Severe Alcoholic Hepatitis Completed NCT02326103 Early Phase 1 Ciprofloxacin;Placebo
21 Influence of Probiotics on Infections in Cirrhosis Completed NCT01607528 Not Applicable
22 Biomarkers for the Prognosis of Decompensated Alcoholic Liver Disease Completed NCT01701687
23 Acoustic Liver Biopsy in Normals and in Patients With Cirrhosis Using Endoscopic Ultrasound Completed NCT01208311
24 Indocyanine Green and Portal Pressure in Viral and Alcoholic Cirrhotic Patients With Hepatocarcinoma Completed NCT00827723
25 Subclinical Myocardial Dysfunction in Patients With Hepatic Cirrhosis Completed NCT01713478 Not Applicable
26 Value on Survival of Liver Volume After an Acute Decompensation of an Alcoholic Cirrhosis Recruiting NCT03508388
27 Comparison of Inflammatory Profiles and Regenerative Potential in Alcoholic Liver Disease Recruiting NCT03773887 Not Applicable
28 Safety and Performance Trial of DIALIVE Liver Dialysis Device in Acute On Chronic Liver Failure Patients Recruiting NCT03065699 Not Applicable
29 Assessment of Nutritional Status of Patients With Liver Cirrhosis Recruiting NCT03242798
30 Mild Hypothermia and Acute Kidney Injury in Liver Transplantation Recruiting NCT03534141 Not Applicable
31 Comparison of ALD, NASH, and Healthy Control Patients Recruiting NCT03224949
32 Boramae Hospital Liver Cirrhosis Patient Cohort Study Recruiting NCT01943318
33 National Cohort of Uncomplicated Alcoholic Cirrhosis Active, not recruiting NCT01213927
34 Validation of the Procedure of Early Liver Transplantation in Alcoholic Hepatitis Resisting to Medical Treatment Active, not recruiting NCT01756794 Not Applicable
35 Zinc Supplementation in Alcoholic Cirrhosis Active, not recruiting NCT02072746 Not Applicable
36 Long-term Follow-up Study of Livercellgram in Alcoholic LC Patients Who Completed Livercellgram Phase 2 Study Enrolling by invitation NCT02806011
37 Prevalence of Exocrine Pancreatic Insufficiency in Patients With Decompensated Cirrhosis Not yet recruiting NCT03236038
38 Influence of ABO Blood Group on the Risk of Complications in Alcoholic or Viral C Cirrhosis? Not yet recruiting NCT03342170

Search NIH Clinical Center for Alcoholic Liver Cirrhosis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Alcoholic Liver Cirrhosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Alcoholic Liver Cirrhosis:
Livercellgram, bone marrow-derived mesenchymal stem cells for treatment of alcoholic liver cirrhosis
Embryonic/Adult Cultured Cells Related to Alcoholic Liver Cirrhosis:
Bone marrow-derived mesenchymal stem cells

Cochrane evidence based reviews: liver cirrhosis, alcoholic

Genetic Tests for Alcoholic Liver Cirrhosis

Anatomical Context for Alcoholic Liver Cirrhosis

MalaCards organs/tissues related to Alcoholic Liver Cirrhosis:

41
Liver, Bone, Skin, T Cells, Testes, B Cells, Bone Marrow
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Alcoholic Liver Cirrhosis:
# Tissue Anatomical CompartmentCell Relevance
1 Liver Liver Lobule Hepatocytes Affected by disease

Publications for Alcoholic Liver Cirrhosis

Articles related to Alcoholic Liver Cirrhosis:

(show top 50) (show all 876)
# Title Authors Year
1
The Impact of Outpatient Clinical Care on the Survival and Hospitalisation Rate in Patients with Alcoholic Liver Cirrhosis. ( 29520208 )
2018
2
Circulating Endothelial Progenitor Cells Present an Inflammatory Phenotype and Function in Patients With Alcoholic Liver Cirrhosis. ( 29872403 )
2018
3
Number of hospital contacts with alcohol problems predicts later risk of alcoholic liver cirrhosis. ( 29528775 )
2018
4
VALIDATION OF CLIF-C-ACLF SCORE FOR ALCOHOLIC LIVER CIRRHOSIS. ( 29905553 )
2018
5
Gallbladder perforation in a patient with alcoholic liver cirrhosis and asymptomatic gallstones: A case report. ( 29718836 )
2018
6
A study of serological markers and lipid profile in non-alcoholic liver cirrhosis patients. ( 29348089 )
2018
7
Successful Distal Gastrectomy for Gastric Cancer with Child-Pugh Class B Alcoholic Liver Cirrhosis. ( 29715144 )
2018
8
Vitamin D supplementation in patients with alcoholic liver cirrhosis: a prospective study. ( 29963831 )
2018
9
An adult patient with alcoholic liver cirrhosis and IgA vasculitis. ( 30024712 )
2018
10
A proteomic approach of biomarker candidate discovery for alcoholic liver cirrhosis. ( 30034555 )
2018
11
Plasmapheresis for Spur Cell Anemia in a Patient with Alcoholic Liver Cirrhosis. ( 30034891 )
2018
12
Opportunities to Prevent Alcoholic Liver Cirrhosis in High-risk Populations: A Systematic Review With Meta-analysis. ( 30353053 )
2018
13
Validation of modified fibrosis-4 index for predicting hepatocellular carcinoma in patients with compensated alcoholic liver cirrhosis. ( 30508959 )
2018
14
Need for surveillance of hepatocellular carcinoma in patients with alcoholic cirrhosis. ( 30318321 )
2018
15
Positive familial history for metabolic traits predisposes to early and more severe alcoholic cirrhosis: A cross-sectional study. ( 30188604 )
2018
16
Levels of circulating follicular helper T cells, T helper 1 cells, and the prognostic significance of soluble form of CD40 ligand on survival in patients with alcoholic cirrhosis. ( 30221017 )
2018
17
A Rare Cause of Gastrointestinal Bleeding in a Patient With a History of Alcoholic Cirrhosis. ( 30240671 )
2018
18
Colder weather and fewer sunlight hours increase alcohol consumption and alcoholic cirrhosis worldwide. ( 30324707 )
2018
19
Hip fracture risk in patients with alcoholic cirrhosis: Do comorbidities and complications matter? ( 30391026 )
2018
20
Reply to: "Hip fracture risk in patients with alcoholic cirrhosis: Do comorbidities and complications matter?" ( 30424897 )
2018
21
Targeting toll-like receptor 7/8 improves host anti-infective response in alcoholic cirrhosis. ( 28687679 )
2018
22
Ethyl Glucuronide in Hair Is an Accurate Biomarker of Chronic Excessive Alcohol Use in Patients With Alcoholic Cirrhosis. ( 28830836 )
2018
23
Alcohol Relapse After Liver Transplantation for Alcoholic Cirrhosis-Impact on Liver Graft and Patient Survival: A Meta-analysis. ( 29194512 )
2018
24
Evaluation of laboratory tests for cirrhosis and for alcohol use, in the context of alcoholic cirrhosis. ( 29277282 )
2018
25
Safety and efficacy of biological therapies in patients with psoriasis with alcoholic cirrhosis: a French retrospective study of 23 cases. ( 29480522 )
2018
26
The high burden of alcoholic cirrhosis in privately insured persons in the United States. ( 29579356 )
2018
27
Primary medullary hemorrhage in a patient with coagulopathy due to alcoholic cirrhosis: A case report. ( 29620649 )
2018
28
Hip fracture risk in patients with alcoholic cirrhosis: A population-based study using English and Danish data. ( 29673756 )
2018
29
A case of colonic varices complicated by alcoholic cirrhosis treated using balloon-occluded retrograde transvenous obliteration. ( 29696582 )
2018
30
Predictive value of liver and spleen stiffness in advanced alcoholic cirrhosis with refractory ascites. ( 29890557 )
2018
31
Quantification and isotopic analysis of bulk and of exchangeable and ultrafiltrable serum copper in healthy and alcoholic cirrhosis subjects. ( 30086927 )
2018
32
Estimate of hepatocellular carcinoma incidence in patients with alcoholic cirrhosis. ( 30092234 )
2018
33
Characterization of Body Composition and Definition of Sarcopenia in Patients with Alcoholic Liver Cirrhosis: a Computed Tomography Based Study. ( 28665532 )
2017
34
Diagnostic specificity and sensitivity of PIVKAII, GP3, CSTB, SCCA1 and HGF for the diagnosis of hepatocellular carcinoma in patients with alcoholic liver cirrhosis. ( 28766361 )
2017
35
A tip from the nose: rhinocerebral mucormycosis in a patient with alcoholic liver cirrhosis and cocaine abuse, an uncommon association. ( 28784893 )
2017
36
Cost of illness of non-alcoholic liver cirrhosis in Japan: A time trend analysis and future projections. ( 28497644 )
2017
37
Bacteremia Caused by Campylobacter Fetus in a Patient With Hepatitis B Virus Infection Complicated with Alcoholic Liver Cirrhosis. ( 28879715 )
2017
38
Disialo-Trisialo Bridging Phenomenon of Transferrin Isoform Detected by Capillary Electrophoresis in Patient with Alcoholic Liver Cirrhosis: First Case Report from Asia. ( 28271694 )
2017
39
Data on gut metagenomes of the patients with alcoholic dependence syndrome and alcoholic liver cirrhosis. ( 28138508 )
2017
40
Relationships between serum selenium and zinc concentrations versus profibrotic and proangiogenic cytokines (FGF-19 and endoglin) in patients with alcoholic liver cirrhosis. ( 28954507 )
2017
41
Association between Serum Selenium Concentrations and Levels of Proinflammatory and Profibrotic Cytokines-Interleukin-6 and Growth Differentiation Factor-15, in Patients with Alcoholic Liver Cirrhosis. ( 28430124 )
2017
42
Reduced platelet activation and platelet aggregation in patients with alcoholic liver cirrhosis. ( 28895774 )
2017
43
IgA nephropathy featuring massive wire loop-like deposits in two patients with alcoholic cirrhosis. ( 29237409 )
2017
44
Predictors of Mortality in Long-Term Follow-Up of Patients with Terminal Alcoholic Cirrhosis: Is It Time to Accept Remodeled Scores? ( 27676412 )
2017
45
Type I interferon signaling in systemic immune cells from patients with alcoholic cirrhosis and its association with outcome. ( 28040548 )
2017
46
Exogenous growth factor based regenerative therapy in alcoholic cirrhosis patients renders limited effect on hemostatic elements. ( 28412190 )
2017
47
Implications of alcoholic cirrhosis in atherosclerosis of autopsied patients. ( 28614536 )
2017
48
Chronic Encapsulated Intracerebral Hematoma: Endoscopic Removal as Minimally Invasive Surgery for a Patient with Alcoholic Cirrhosis. ( 28664027 )
2017
49
Isolation of Induced Pluripotent Cells from Stromal Liver Cells of Patients with Alcoholic Cirrhosis. ( 28853085 )
2017
50
Reduced risk of decompensation and death associated with use of statins in patients with alcoholic cirrhosis. A nationwide case-cohort study. ( 28880449 )
2017

Variations for Alcoholic Liver Cirrhosis

Expression for Alcoholic Liver Cirrhosis

Search GEO for disease gene expression data for Alcoholic Liver Cirrhosis.

Pathways for Alcoholic Liver Cirrhosis

Pathways related to Alcoholic Liver Cirrhosis according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.89 ADH1B ADH1C ADH4 ALB ALDH2 CYP2A6
2
Show member pathways
12.86 ADH1B ADH1C ADH4 ALDH2 CYP2A6 CYP2E1
3
Show member pathways
12.46 ADH1B ADH1C ADH4 ALDH2
4
Show member pathways
12.04 ADH1B ALDH2 CYP2A6 CYP2E1
5
Show member pathways
11.93 ADH1B ADH1C ADH4 ALDH2 CYP2A6 CYP2E1
6
Show member pathways
11.67 ADH1B ADH1C ADH4 ALDH2
7
Show member pathways
11.61 CYP2A6 CYP2E1 GSTM1
8
Show member pathways
11.59 ADH1B ADH1C ADH4
9 11.3 AFP ALB F2
10
Show member pathways
11.06 CYP2A6 CYP2E1 NAT2
11 10.99 CYP2A6 CYP2E1 GSTM1
12 10.87 CYP2A6 CYP2E1
13
Show member pathways
10.75 ADH1B ADH1C ADH4 ALDH2
14
Show member pathways
10.72 ADH1B ALDH2 CYP2E1
15
Show member pathways
10.69 ADH1B ADH1C
16
Show member pathways
10.67 ADH1B ADH4 ALDH2
17
Show member pathways
10.37 ADH1B CYP2A6 CYP2E1
18 10.29 CYP2E1 GSTM1

GO Terms for Alcoholic Liver Cirrhosis

Cellular components related to Alcoholic Liver Cirrhosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 9.26 AHSG ALB F2 TF
2 endoplasmic reticulum lumen GO:0005788 9.02 AFP AHSG ALB F2 TF

Biological processes related to Alcoholic Liver Cirrhosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.67 AFP AHSG ALB TF
2 oxidation-reduction process GO:0055114 9.63 ADH1B ADH1C ADH4 ALDH2 CYP2A6 CYP2E1
3 platelet degranulation GO:0002576 9.58 AHSG ALB TF
4 xenobiotic metabolic process GO:0006805 9.5 CYP2A6 CYP2E1 NAT2
5 drug metabolic process GO:0017144 9.49 CYP2A6 CYP2E1
6 exogenous drug catabolic process GO:0042738 9.48 CYP2A6 CYP2E1
7 organic acid metabolic process GO:0006082 9.46 CYP2A6 CYP2E1
8 epoxygenase P450 pathway GO:0019373 9.43 CYP2A6 CYP2E1
9 cellular protein metabolic process GO:0044267 9.35 AFP AHSG ALB F2 TF
10 alcohol metabolic process GO:0006066 9.26 ADH4 ALDH2
11 ethanol oxidation GO:0006069 8.92 ADH1B ADH1C ADH4 ALDH2

Molecular functions related to Alcoholic Liver Cirrhosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.43 ADH1B ADH1C ADH4 ALDH2 CYP2A6 CYP2E1
2 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0016620 9.37 ADH4 ALDH2
3 retinol dehydrogenase activity GO:0004745 9.32 ADH1C ADH4
4 arachidonic acid epoxygenase activity GO:0008392 9.26 CYP2A6 CYP2E1
5 alcohol dehydrogenase (NAD) activity GO:0004022 9.16 ADH1C ADH4
6 alcohol dehydrogenase activity, zinc-dependent GO:0004024 8.8 ADH1B ADH1C ADH4

Sources for Alcoholic Liver Cirrhosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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