MCID: ALC011
MIFTS: 30

Alcoholic Neuropathy

Categories: Neuronal diseases

Aliases & Classifications for Alcoholic Neuropathy

MalaCards integrated aliases for Alcoholic Neuropathy:

Name: Alcoholic Neuropathy 12 56 45 15 17 74
Alcohol-Related Polyneuropathy 12
Alcoholic Polyneuropathy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14183
ICD9CM 36 357.5
MeSH 45 D020269
NCIt 51 C26926
SNOMED-CT 69 7916009
ICD10 34 G62.1
UMLS 74 C0085677

Summaries for Alcoholic Neuropathy

MalaCards based summary : Alcoholic Neuropathy, also known as alcohol-related polyneuropathy, is related to neuropathy and polyneuropathy. An important gene associated with Alcoholic Neuropathy is ALDH2 (Aldehyde Dehydrogenase 2 Family Member), and among its related pathways/superpathways are Porphyrin and chlorophyll metabolism and Fatty acid metabolism. The drugs Ethanol and Liver Extracts have been mentioned in the context of this disorder. Affiliated tissues include liver and skin.

Wikipedia : 77 Alcoholic polyneuropathy is a neurological disorder in which peripheral nerves throughout the body... more...

Related Diseases for Alcoholic Neuropathy

Diseases related to Alcoholic Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 neuropathy 10.5
2 polyneuropathy 10.3
3 beriberi 9.7
4 alcoholic liver cirrhosis 9.7 ADH4 ALDH2
5 alcohol dependence 9.5 ADH4 ALDH2
6 inflammatory and toxic neuropathy 8.7 ADH4 ALDH2 MIA3 SPTLC1 UROS

Comorbidity relations with Alcoholic Neuropathy via Phenotypic Disease Network (PDN):


Acute Cystitis Alcohol Abuse
Alcoholic Hepatitis Alcoholic Liver Cirrhosis
Deficiency Anemia Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Alcoholic Neuropathy:



Diseases related to Alcoholic Neuropathy

Symptoms & Phenotypes for Alcoholic Neuropathy

Drugs & Therapeutics for Alcoholic Neuropathy

Drugs for Alcoholic Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved 64-17-5 702
2 Liver Extracts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cutaneous Denervation in Alcoholic Neuropathy Unknown status NCT00190073
2 Somatic Disease Among Alcohol Abusers in an Out-day Patients' Clinic Completed NCT01081197

Search NIH Clinical Center for Alcoholic Neuropathy

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: alcoholic neuropathy

Genetic Tests for Alcoholic Neuropathy

Anatomical Context for Alcoholic Neuropathy

MalaCards organs/tissues related to Alcoholic Neuropathy:

42
Liver, Skin

Publications for Alcoholic Neuropathy

Articles related to Alcoholic Neuropathy:

(show all 40)
# Title Authors Year
1
Alcoholic neuropathy: possible mechanisms and future treatment possibilities. ( 21988193 )
2012
2
Therapeutic role of curcumin in prevention of biochemical and behavioral aberration induced by alcoholic neuropathy in laboratory animals. ( 22281447 )
2012
3
Electrophysiological and behavioral changes by phosphodiesterase 4 inhibitor in a rat model of alcoholic neuropathy. ( 22993675 )
2012
4
Evaluation of ameliorative effect of quercetin in experimental model of alcoholic neuropathy in rats. ( 22349996 )
2012
5
Amelioration of functional, biochemical and molecular deficits by epigallocatechin gallate in experimental model of alcoholic neuropathy. ( 20699198 )
2011
6
Tocotrienol ameliorates behavioral and biochemical alterations in the rat model of alcoholic neuropathy. ( 19541419 )
2009
7
Alcohol-induced stress in painful alcoholic neuropathy. ( 18093169 )
2008
8
Alcoholic neuropathy. ( 16969158 )
2006
9
Resolution of alcoholic neuropathy following liver transplantation. ( 15558589 )
2004
10
Alcoholic neuropathy is clinicopathologically distinct from thiamine-deficiency neuropathy. ( 12838517 )
2003
11
Pathogenesis of alcoholic neuropathy. ( 12061083 )
2002
12
Key role for the epsilon isoform of protein kinase C in painful alcoholic neuropathy in the rat. ( 11069970 )
2000
13
Changes in sympathetic and parasympathetic function in alcoholic neuropathy. ( 9549310 )
1998
14
Mexiletine for painful alcoholic neuropathy. ( 7549147 )
1995
15
Sympathetic dysfunction mediating cardiovascular regulation in alcoholic neuropathy. ( 7926889 )
1994
16
Comparison of sympathetic sudomotor and skin responses in alcoholic neuropathy. ( 8455654 )
1993
17
Acute or subacute alcoholic neuropathy mimicking Guillain-Barré syndrome. ( 2401897 )
1990
18
The haematic thiamine level in the course of alcoholic neuropathy. ( 3032641 )
1987
19
The primary role of the Erb's point--axilla segment in median and ulnar motor nerve conduction determinations in alcoholic neuropathy. ( 3011999 )
1986
20
Sympathetic vasoconstrictor nerve function in alcoholic neuropathy. ( 6540153 )
1984
21
Alcoholic neuropathy and hepatopathy in mice. An experimental study. ( 6303042 )
1983
22
Alcoholic neuropathy associated with the eighth cranial nerve. ( 6867249 )
1983
23
Alcohol, nutrition, and the nervous system. Alcoholic neuropathy. ( 6292675 )
1982
24
Drinking habits and peripheral alcoholic neuropathy. ( 6278809 )
1982
25
Eighth nerve alcoholic neuropathy: a case report with light and electron microscopic findings. ( 7252342 )
1981
26
Quantitative electrophysiological study of alcoholic neuropathy. ( 7420094 )
1980
27
Animal models of alcoholic neuropathy: morphologic, electrophysiologic, and biochemical findings. ( 232540 )
1979
28
Experimental alcoholic neuropathy in the rat: histological and electrophysiological study on the myoneural junctions and the peripheral nerves. ( 205081 )
1978
29
Respective importance of different electrophysiological parameters in alcoholic neuropathy. ( 199711 )
1977
30
Correlation of electrophysiological and quantitative histological findings in the sural nerve of man. Studies on alcoholic neuropathy. ( 72812 )
1977
31
The sympathetic nervous system in alcoholic neuropathy. A clinical and pathological study. ( 171025 )
1975
32
Alcoholic neuropathy. An electron-microscopic study. ( 169325 )
1975
33
Electrophysiological evidence for a distal lesion in alcoholic neuropathy. ( 4343480 )
1972
34
Pathogenesis of diabetic and alcoholic neuropathy. ( 5546239 )
1971
35
Alcoholic neuropathy. ( 4328432 )
1970
36
Alcoholic neuropathy. An electrophysiological and histological study. ( 4315536 )
1970
37
Deterioration of esophageal peristalsis in patients with alcoholic neuropathy. ( 4298673 )
1968
38
Alcoholic neuropathy. Its characteristic picture and variants viewed in the light of electromyography. ( 13766774 )
1961
39
ALCOHOLIC neuropathy. ( 13050905 )
1953
40
Alcoholic neuropathy and Laennec's cirrhosis. ( 15412051 )
1950

Variations for Alcoholic Neuropathy

Expression for Alcoholic Neuropathy

Search GEO for disease gene expression data for Alcoholic Neuropathy.

Pathways for Alcoholic Neuropathy

GO Terms for Alcoholic Neuropathy

Biological processes related to Alcoholic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ethanol oxidation GO:0006069 8.96 ADH4 ALDH2
2 alcohol metabolic process GO:0006066 8.62 ADH4 ALDH2

Molecular functions related to Alcoholic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NAD binding GO:0051287 8.96 ADH4 ALDH2
2 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0016620 8.62 ADH4 ALDH2

Sources for Alcoholic Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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