MCID: ALC011
MIFTS: 35

Alcoholic Neuropathy

Categories: Neuronal diseases

Aliases & Classifications for Alcoholic Neuropathy

MalaCards integrated aliases for Alcoholic Neuropathy:

Name: Alcoholic Neuropathy 12 55 44 15 17 72
Alcoholic Polyneuropathy 12 33
Alcohol-Related Polyneuropathy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14183
ICD9CM 35 357.5
MeSH 44 D020269
NCIt 50 C26926
SNOMED-CT 68 7916009
ICD10 33 G62.1
UMLS 72 C0085677

Summaries for Alcoholic Neuropathy

MalaCards based summary : Alcoholic Neuropathy, also known as alcoholic polyneuropathy, is related to alcohol dependence and neuropathy. An important gene associated with Alcoholic Neuropathy is ALDH2 (Aldehyde Dehydrogenase 2 Family Member), and among its related pathways/superpathways are Porphyrin and chlorophyll metabolism and Cyclophosphamide Pathway, Pharmacodynamics. The drugs Tocopherol and Vitamin E have been mentioned in the context of this disorder. Affiliated tissues include liver, skin and testes.

Wikipedia : 75 Alcoholic polyneuropathy is a neurological disorder in which peripheral nerves throughout the body... more...

Related Diseases for Alcoholic Neuropathy

Graphical network of the top 20 diseases related to Alcoholic Neuropathy:



Diseases related to Alcoholic Neuropathy

Symptoms & Phenotypes for Alcoholic Neuropathy

Drugs & Therapeutics for Alcoholic Neuropathy

Drugs for Alcoholic Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tocopherol Approved, Investigational Phase 3 1406-66-2, 54-28-4 14986
2
Vitamin E Approved, Nutraceutical, Vet_approved Phase 3 59-02-9 14985
3 Tocotrienol Investigational Phase 3 6829-55-6
4 Micronutrients Phase 3
5 Trace Elements Phase 3
6 Antioxidants Phase 3
7 Vitamins Phase 3
8 Tocopherols Phase 3
9 Tocotrienols Phase 3
10 Protective Agents Phase 3
11 Nutrients Phase 3
12
Ethanol Approved 64-17-5 702
13 Anti-Infective Agents, Local
14 Central Nervous System Depressants
15 Liver Extracts
16 Anti-Infective Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Clinical Study on the Neuroprotection by Tocotrienols in Type 1 and Type 2 Diabetes Mellitus Completed NCT01973400 Phase 3
2 Cutaneous Denervation in Alcoholic Neuropathy Unknown status NCT00190073
3 Somatic Disease Among Alcohol Abusers in an Out-day Patients' Clinic. A Neglected Area Completed NCT01081197

Search NIH Clinical Center for Alcoholic Neuropathy

Inferred drug relations via UMLS 72 / NDF-RT 51 :


COBALAMIN CONCENTRATE
Hydroxocobalamin
HYDROXOCOBALAMIN ACETATE
mecobalamin
Thiamine hydrochloride
Thiamine Mononitrate
Vitamin B 12

Cochrane evidence based reviews: alcoholic neuropathy

Genetic Tests for Alcoholic Neuropathy

Anatomical Context for Alcoholic Neuropathy

MalaCards organs/tissues related to Alcoholic Neuropathy:

41
Liver, Skin, Testes, Brain, Heart, Skeletal Muscle

Publications for Alcoholic Neuropathy

Articles related to Alcoholic Neuropathy:

(show top 50) (show all 175)
# Title Authors PMID Year
1
Influence of genetic variations of ethanol-metabolizing enzymes on phenotypes of alcohol-related disorders. 9 38
15542751 2004
2
Association of aldehyde dehydrogenase-2 polymorphism with alcoholic polyneuropathy in humans. 9 38
15182962 2004
3
Role of curcumin in the management of pathological pain. 38
30195871 2018
4
Disulfiram neuropathy: two case reports. 38
27029711 2016
5
[EXPERIMENTAL MODELS OF ALCOHOLIC NEUROPATHY IN RATS.] 38
29791100 2016
6
Natural products evaluated in neuropathic pain models - a systematic review. 38
24252102 2014
7
[Neurological complications of chronic alcoholism: study of 42 observations in Guinea]. 38
24846812 2014
8
Peripheral systems: neuropathy. 38
25307593 2014
9
[Peripheral nerve disorders as common diseases]. 38
24018743 2013
10
Botulinum toxin type A combined with neurodynamic mobilization for lower limb spasticity: a case report. 38
23997723 2013
11
Solid bolt fixation of the medial column in Charcot midfoot arthropathy. 38
22951022 2013
12
Erythrocyte transketolase activity in patients with diabetic and alcoholic neuropathies. 38
24114639 2013
13
Evaluation of ameliorative effect of quercetin in experimental model of alcoholic neuropathy in rats. 38
22349996 2012
14
Neuroprotective effect of vitamin E isoforms against chronic alcohol-induced peripheral neurotoxicity: possible involvement of oxidative-nitrodative stress. 38
22422517 2012
15
Electrophysiological and behavioral changes by phosphodiesterase 4 inhibitor in a rat model of alcoholic neuropathy. 38
22993675 2012
16
[Disulfiram-induced polyneurophaty]. 38
22764551 2012
17
Alcoholic neuropathy: possible mechanisms and future treatment possibilities. 38
21988193 2012
18
Therapeutic role of curcumin in prevention of biochemical and behavioral aberration induced by alcoholic neuropathy in laboratory animals. 38
22281447 2012
19
Amelioration of functional, biochemical and molecular deficits by epigallocatechin gallate in experimental model of alcoholic neuropathy. 38
20699198 2011
20
Alcohol-induced persistent mild cognitive impairment with successful withdrawal from alcohol dependence--a case report. 38
21675042 2011
21
Attenuation of activity in an endogenous analgesia circuit by ongoing pain in the rat. 38
20943910 2010
22
Tocotrienol ameliorates behavioral and biochemical alterations in the rat model of alcoholic neuropathy. 38
19541419 2009
23
[Metabolic and nutritional neuropathy]. 38
19198152 2008
24
Strength-duration properties of sensory and motor axons in alcoholic polyneuropathy. 38
18489821 2008
25
Neurotoxic catecholamine metabolite in nociceptors contributes to painful peripheral neuropathy. 38
18783367 2008
26
Hereditary sensory neuropathy type I. 38
18348718 2008
27
Alcohol-induced neuroarthropathy in the foot: a case series and review of literature. 38
18312919 2008
28
Alcohol-induced stress in painful alcoholic neuropathy. 38
18093169 2008
29
Disulfiram induced peripheral neuropathy: between the devil and the deep blue sea. 38
30290491 2007
30
[Neuropathic arthropathy of the shoulder]. 38
18227903 2007
31
Impact of cytokines on the pathomechanism of diabetic and alcoholic neuropathies. 38
17594598 2007
32
Treatment of alcoholic polyneuropathy with vitamin B complex: a randomised controlled trial. 38
16926172 2006
33
Alcoholic neuropathy. 38
16969158 2006
34
[The tebantin use in the complex therapy of pain syndrome during the mixed forms of alcoholic polyneuropathy]. 38
17236668 2006
35
Poisoning or primary nervous system disease?--difficulties of the differential diagnosis exemplified by four different clinical cases. 38
16225102 2005
36
Resolution of alcoholic neuropathy following liver transplantation. 38
15558589 2004
37
Alcoholic neuropathy is clinicopathologically distinct from thiamine-deficiency neuropathy. 38
12838517 2003
38
[Neurologic sequelae of chronic alcoholism]. 38
12666505 2003
39
Current perception threshold and sympathetic skin response in diabetic and alcoholic polyneuropathies. 38
12413002 2002
40
[Disulfiram neuropathy. Report of 3 cases]. 38
12434653 2002
41
T-wave response: a sensitive test for latent alcoholic polyneuropathy. 38
12126491 2002
42
Pathogenesis of alcoholic neuropathy. 38
12061083 2002
43
[Electroneuromyographic criteria of partial motor conduction block and temporal dispersion in patients with alcoholic polyneuropathy]. 38
11842623 2002
44
Alcoholic polyneuropathy: a clinical and epidemiological study. 38
11524304 2001
45
[Alcohol polyneuropathy]. 38
11584682 2001
46
Painful alcoholic polyneuropathy with predominant small-fiber loss and normal thiamine status. 38
11425941 2001
47
[Bendotiamine efficacy in alcoholic polyneuropathy therapy]. 38
11811123 2001
48
Key role for the epsilon isoform of protein kinase C in painful alcoholic neuropathy in the rat. 38
11069970 2000
49
[Alcohol and the peripheral nervous system]. 38
10804876 2000
50
Clinicopathologic analysis of 124 biopsy-proven peripheral nerve diseases. 38
10803700 2000

Variations for Alcoholic Neuropathy

Expression for Alcoholic Neuropathy

Search GEO for disease gene expression data for Alcoholic Neuropathy.

Pathways for Alcoholic Neuropathy

GO Terms for Alcoholic Neuropathy

Biological processes related to Alcoholic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ethanol oxidation GO:0006069 8.96 ALDH2 ADH4
2 alcohol metabolic process GO:0006066 8.62 ALDH2 ADH4

Molecular functions related to Alcoholic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NAD binding GO:0051287 8.96 ALDH2 ADH4
2 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0016620 8.62 ALDH2 ADH4

Sources for Alcoholic Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
Content
Loading form....