MCID: ALC011
MIFTS: 31

Alcoholic Neuropathy

Categories: Neuronal diseases

Aliases & Classifications for Alcoholic Neuropathy

MalaCards integrated aliases for Alcoholic Neuropathy:

Name: Alcoholic Neuropathy 12 55 44 15 73
Alcohol-Related Polyneuropathy 12
Alcoholic Polyneuropathy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14183
ICD10 33 G62.1
ICD9CM 35 357.5
MeSH 44 D020269
NCIt 50 C26926
UMLS 73 C0085677

Summaries for Alcoholic Neuropathy

MalaCards based summary : Alcoholic Neuropathy, also known as alcohol-related polyneuropathy, is related to neuropathy and polyneuropathy. An important gene associated with Alcoholic Neuropathy is ALDH2 (Aldehyde Dehydrogenase 2 Family Member), and among its related pathways/superpathways are Porphyrin and chlorophyll metabolism and Fatty acid metabolism. The drugs Ethanol and Liver Extracts have been mentioned in the context of this disorder. Affiliated tissues include liver and skin.

Wikipedia : 76 Alcoholic polyneuropathy (A.K.A alcohol leg) is a neurological disorder in which peripheral nerves... more...

Related Diseases for Alcoholic Neuropathy

Diseases related to Alcoholic Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 neuropathy 10.4
2 polyneuropathy 9.7
3 esophagitis 9.6
4 beriberi 9.6
5 alcoholic liver cirrhosis 9.3 ADH4 ALDH2
6 alcohol dependence 9.1 ADH4 ALDH2
7 inflammatory and toxic neuropathy 8.1 ADH4 ALDH2 MIA3 SPTLC1

Comorbidity relations with Alcoholic Neuropathy via Phenotypic Disease Network (PDN):


Acute Cystitis Alcohol Abuse
Alcoholic Hepatitis Alcoholic Liver Cirrhosis
Deficiency Anemia Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Alcoholic Neuropathy:



Diseases related to Alcoholic Neuropathy

Symptoms & Phenotypes for Alcoholic Neuropathy

Drugs & Therapeutics for Alcoholic Neuropathy

Drugs for Alcoholic Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved 64-17-5 702
2 Liver Extracts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cutaneous Denervation in Alcoholic Neuropathy Unknown status NCT00190073
2 Somatic Disease Among Alcohol Abusers in an Out-day Patients' Clinic Completed NCT01081197

Search NIH Clinical Center for Alcoholic Neuropathy

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: alcoholic neuropathy

Genetic Tests for Alcoholic Neuropathy

Anatomical Context for Alcoholic Neuropathy

MalaCards organs/tissues related to Alcoholic Neuropathy:

41
Liver, Skin

Publications for Alcoholic Neuropathy

Articles related to Alcoholic Neuropathy:

(show all 42)
# Title Authors Year
1
Erythrocyte transketolase activity in patients with diabetic and alcoholic neuropathies. ( 24114639 )
2013
2
Electrophysiological and behavioral changes by phosphodiesterase 4 inhibitor in a rat model of alcoholic neuropathy. ( 22993675 )
2012
3
Therapeutic role of curcumin in prevention of biochemical and behavioral aberration induced by alcoholic neuropathy in laboratory animals. ( 22281447 )
2012
4
Evaluation of ameliorative effect of quercetin in experimental model of alcoholic neuropathy in rats. ( 22349996 )
2012
5
Alcoholic neuropathy: possible mechanisms and future treatment possibilities. ( 21988193 )
2012
6
Amelioration of functional, biochemical and molecular deficits by epigallocatechin gallate in experimental model of alcoholic neuropathy. ( 20699198 )
2011
7
Tocotrienol ameliorates behavioral and biochemical alterations in the rat model of alcoholic neuropathy. ( 19541419 )
2009
8
Alcohol-induced stress in painful alcoholic neuropathy. ( 18093169 )
2008
9
Impact of cytokines on the pathomechanism of diabetic and alcoholic neuropathies. ( 17594598 )
2007
10
Alcoholic neuropathy. ( 16969158 )
2006
11
Resolution of alcoholic neuropathy following liver transplantation. ( 15558589 )
2004
12
Alcoholic neuropathy is clinicopathologically distinct from thiamine-deficiency neuropathy. ( 12838517 )
2003
13
Pathogenesis of alcoholic neuropathy. ( 12061083 )
2002
14
Key role for the epsilon isoform of protein kinase C in painful alcoholic neuropathy in the rat. ( 11069970 )
2000
15
Changes in sympathetic and parasympathetic function in alcoholic neuropathy. ( 9549310 )
1998
16
Mexiletine for painful alcoholic neuropathy. ( 7549147 )
1995
17
Sympathetic dysfunction mediating cardiovascular regulation in alcoholic neuropathy. ( 7926889 )
1994
18
Comparison of sympathetic sudomotor and skin responses in alcoholic neuropathy. ( 8455654 )
1993
19
Acute or subacute alcoholic neuropathy mimicking Guillain-BarrAc syndrome. ( 2401897 )
1990
20
The haematic thiamine level in the course of alcoholic neuropathy. ( 3032641 )
1987
21
The primary role of the Erb's point--axilla segment in median and ulnar motor nerve conduction determinations in alcoholic neuropathy. ( 3011999 )
1986
22
Sympathetic vasoconstrictor nerve function in alcoholic neuropathy. ( 6540153 )
1984
23
Alcoholic neuropathy associated with the eighth cranial nerve. ( 6867249 )
1983
24
Alcoholic neuropathy and hepatopathy in mice. An experimental study. ( 6303042 )
1983
25
Alcohol, nutrition, and the nervous system. Alcoholic neuropathy. ( 6292675 )
1982
26
Drinking habits and peripheral alcoholic neuropathy. ( 6278809 )
1982
27
Eighth nerve alcoholic neuropathy: a case report with light and electron microscopic findings. ( 7252342 )
1981
28
Quantitative electrophysiological study of alcoholic neuropathy. ( 7420094 )
1980
29
Animal models of alcoholic neuropathy: morphologic, electrophysiologic, and biochemical findings. ( 232540 )
1979
30
Experimental alcoholic neuropathy in the rat: histological and electrophysiological study on the myoneural junctions and the peripheral nerves. ( 205081 )
1978
31
Correlation of electrophysiological and quantitative histological findings in the sural nerve of man. Studies on alcoholic neuropathy. ( 72812 )
1977
32
Respective importance of different electrophysiological parameters in alcoholic neuropathy. ( 199711 )
1977
33
The sympathetic nervous system in alcoholic neuropathy. A clinical and pathological study. ( 171025 )
1975
34
Alcoholic neuropathy. An electron-microscopic study. ( 169325 )
1975
35
Electrophysiological evidence for a distal lesion in alcoholic neuropathy. ( 4343480 )
1972
36
Pathogenesis of diabetic and alcoholic neuropathy. ( 5546239 )
1971
37
Alcoholic neuropathy. An electrophysiological and histological study. ( 4315536 )
1970
38
Alcoholic neuropathy. ( 4328432 )
1970
39
Deterioration of esophageal peristalsis in patients with alcoholic neuropathy. ( 4298673 )
1968
40
Alcoholic neuropathy. Its characteristic picture and variants viewed in the light of electromyography. ( 13766774 )
1961
41
ALCOHOLIC neuropathy. ( 13050905 )
1953
42
Alcoholic neuropathy and Laennec's cirrhosis. ( 15412051 )
1950

Variations for Alcoholic Neuropathy

Expression for Alcoholic Neuropathy

Search GEO for disease gene expression data for Alcoholic Neuropathy.

Pathways for Alcoholic Neuropathy

GO Terms for Alcoholic Neuropathy

Biological processes related to Alcoholic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ethanol oxidation GO:0006069 8.96 ADH4 ALDH2
2 alcohol metabolic process GO:0006066 8.62 ADH4 ALDH2

Molecular functions related to Alcoholic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NAD binding GO:0051287 8.96 ADH4 ALDH2
2 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0016620 8.62 ADH4 ALDH2

Sources for Alcoholic Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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