MCID: ALC011
MIFTS: 37

Alcoholic Neuropathy

Categories: Neuronal diseases

Aliases & Classifications for Alcoholic Neuropathy

MalaCards integrated aliases for Alcoholic Neuropathy:

Name: Alcoholic Neuropathy 12 54 43 15 17 71
Alcoholic Polyneuropathy 12 32
Alcohol-Related Polyneuropathy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14183
ICD9CM 34 357.5
MeSH 43 D020269
NCIt 49 C26926
SNOMED-CT 67 7916009
ICD10 32 G62.1
UMLS 71 C0085677

Summaries for Alcoholic Neuropathy

MalaCards based summary : Alcoholic Neuropathy, also known as alcoholic polyneuropathy, is related to beriberi and peripheral nervous system disease. An important gene associated with Alcoholic Neuropathy is ALDH2 (Aldehyde Dehydrogenase 2 Family Member), and among its related pathways/superpathways are Arginine and proline metabolism and Histidine metabolism. The drugs Tocopherol and Vitamin E have been mentioned in the context of this disorder. Affiliated tissues include liver, skin and testes.

Wikipedia : 74 Alcoholic polyneuropathy is a neurological disorder in which peripheral nerves throughout the body... more...

Related Diseases for Alcoholic Neuropathy

Diseases related to Alcoholic Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
# Related Disease Score Top Affiliating Genes
1 beriberi 30.4 TKT THTPA
2 peripheral nervous system disease 30.0 TRPA1 NAA50 GAN
3 wernicke encephalopathy 29.9 TKT THTPA
4 alcohol dependence 29.1 MAOA ALDH2 ADH4
5 neuropathy 10.6
6 wernicke-korsakoff syndrome 10.1 TKT THTPA
7 polyneuropathy 10.1
8 alcohol use disorder 9.9
9 myopathy 9.9
10 heroin dependence 9.9 MAOA ALDH2
11 fetal alcohol spectrum disorder 9.9 ALDH2 ADH4
12 antisocial personality disorder 9.9 MAOA ALDH2
13 neuropathy, hereditary, with liability to pressure palsies 9.9 NAA50 GAN
14 neurotic disorder 9.9 MAOA GAN
15 liver disease 9.9
16 axonal neuropathy 9.9
17 diabetic neuropathy 9.9
18 multiple sclerosis 9.8
19 erythermalgia, primary 9.8
20 autonomic neuropathy 9.8
21 hepatitis a 9.8
22 diabetic polyneuropathy 9.8
23 syphilis 9.8
24 movement disease 9.8
25 diabetes mellitus 9.8
26 latent syphilis 9.8
27 painful legs and moving toes syndrome 9.8
28 cerebral beriberi 9.8
29 encephalopathy 9.8
30 hypoxia 9.8
31 3-methylglutaconic aciduria, type iii 9.7
32 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.7
33 partial optic atrophy 9.7
34 anhidrosis 9.7
35 optic neuritis 9.7
36 guillain-barre syndrome 9.7
37 neuritis 9.7
38 optic nerve disease 9.7
39 liver cirrhosis 9.7
40 subacute delirium 9.7
41 pure autonomic failure 9.7
42 wallerian degeneration 9.7
43 chronic pain 9.7
44 substance dependence 9.6 MAOA ALDH2 ADH4
45 inflammatory and toxic neuropathy 8.7 TKT THTPA SNN NAA50 MIDN MIA3

Comorbidity relations with Alcoholic Neuropathy via Phenotypic Disease Network (PDN):


Acute Cystitis Alcoholic Hepatitis
Alcoholic Liver Cirrhosis Deficiency Anemia
Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Alcoholic Neuropathy:



Diseases related to Alcoholic Neuropathy

Symptoms & Phenotypes for Alcoholic Neuropathy

Drugs & Therapeutics for Alcoholic Neuropathy

Drugs for Alcoholic Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tocopherol Approved, Investigational Phase 3 1406-66-2, 54-28-4 14986
2
Vitamin E Approved, Nutraceutical, Vet_approved Phase 3 59-02-9 14985
3 Tocotrienol Investigational Phase 3 6829-55-6
4 Vitamins Phase 3
5 Trace Elements Phase 3
6 Micronutrients Phase 3
7 Nutrients Phase 3
8 Tocopherols Phase 3
9 Antioxidants Phase 3
10 Tocotrienols Phase 3
11 Protective Agents Phase 3
12
Ethanol Approved 64-17-5 702
13 Liver Extracts
14 Central Nervous System Depressants
15 Anti-Infective Agents, Local
16 Anti-Infective Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Clinical Study on the Neuroprotection by Tocotrienols in Type 1 and Type 2 Diabetes Mellitus Completed NCT01973400 Phase 3
2 Cutaneous Denervation in Alcoholic Neuropathy Unknown status NCT00190073
3 Somatic Disease Among Alcohol Abusers in an Out-day Patients' Clinic. A Neglected Area Completed NCT01081197

Search NIH Clinical Center for Alcoholic Neuropathy

Inferred drug relations via UMLS 71 / NDF-RT 50 :


COBALAMIN CONCENTRATE
Hydroxocobalamin
HYDROXOCOBALAMIN ACETATE
mecobalamin
Thiamine hydrochloride
Thiamine Mononitrate
Vitamin B 12

Cochrane evidence based reviews: alcoholic neuropathy

Genetic Tests for Alcoholic Neuropathy

Anatomical Context for Alcoholic Neuropathy

MalaCards organs/tissues related to Alcoholic Neuropathy:

40
Liver, Skin, Testes, Brain, Heart, Skeletal Muscle

Publications for Alcoholic Neuropathy

Articles related to Alcoholic Neuropathy:

(show top 50) (show all 177)
# Title Authors PMID Year
1
Influence of genetic variations of ethanol-metabolizing enzymes on phenotypes of alcohol-related disorders. 54 61
15542751 2004
2
Association of aldehyde dehydrogenase-2 polymorphism with alcoholic polyneuropathy in humans. 54 61
15182962 2004
3
Spatial analysis of alcohol-related mortality in Slovakia. 61
31901192 2019
4
Schwann cells expressing nociceptive channel TRPA1 orchestrate ethanol-evoked neuropathic pain in mice. 61
31487269 2019
5
Role of curcumin in the management of pathological pain. 61
30195871 2018
6
Disulfiram neuropathy: two case reports. 61
27029711 2016
7
[EXPERIMENTAL MODELS OF ALCOHOLIC NEUROPATHY IN RATS.] 61
29791100 2016
8
Natural products evaluated in neuropathic pain models - a systematic review. 61
24252102 2014
9
[Neurological complications of chronic alcoholism: study of 42 observations in Guinea]. 61
24846812 2014
10
Peripheral systems: neuropathy. 61
25307593 2014
11
[Peripheral nerve disorders as common diseases]. 61
24018743 2013
12
Botulinum toxin type A combined with neurodynamic mobilization for lower limb spasticity: a case report. 61
23997723 2013
13
Erythrocyte transketolase activity in patients with diabetic and alcoholic neuropathies. 61
24114639 2013
14
Solid bolt fixation of the medial column in Charcot midfoot arthropathy. 61
22951022 2013
15
Evaluation of ameliorative effect of quercetin in experimental model of alcoholic neuropathy in rats. 61
22349996 2012
16
Neuroprotective effect of vitamin E isoforms against chronic alcohol-induced peripheral neurotoxicity: possible involvement of oxidative-nitrodative stress. 61
22422517 2012
17
Electrophysiological and behavioral changes by phosphodiesterase 4 inhibitor in a rat model of alcoholic neuropathy. 61
22993675 2012
18
[Disulfiram-induced polyneurophaty]. 61
22764551 2012
19
Alcoholic neuropathy: possible mechanisms and future treatment possibilities. 61
21988193 2012
20
Therapeutic role of curcumin in prevention of biochemical and behavioral aberration induced by alcoholic neuropathy in laboratory animals. 61
22281447 2012
21
Amelioration of functional, biochemical and molecular deficits by epigallocatechin gallate in experimental model of alcoholic neuropathy. 61
20699198 2011
22
Alcohol-induced persistent mild cognitive impairment with successful withdrawal from alcohol dependence--a case report. 61
21675042 2011
23
Attenuation of activity in an endogenous analgesia circuit by ongoing pain in the rat. 61
20943910 2010
24
Tocotrienol ameliorates behavioral and biochemical alterations in the rat model of alcoholic neuropathy. 61
19541419 2009
25
[Metabolic and nutritional neuropathy]. 61
19198152 2008
26
Strength-duration properties of sensory and motor axons in alcoholic polyneuropathy. 61
18489821 2008
27
Neurotoxic catecholamine metabolite in nociceptors contributes to painful peripheral neuropathy. 61
18783367 2008
28
Hereditary sensory neuropathy type I. 61
18348718 2008
29
Alcohol-induced neuroarthropathy in the foot: a case series and review of literature. 61
18312919 2008
30
Alcohol-induced stress in painful alcoholic neuropathy. 61
18093169 2008
31
Disulfiram induced peripheral neuropathy: between the devil and the deep blue sea. 61
30290491 2007
32
[Neuropathic arthropathy of the shoulder]. 61
18227903 2007
33
Impact of cytokines on the pathomechanism of diabetic and alcoholic neuropathies. 61
17594598 2007
34
Treatment of alcoholic polyneuropathy with vitamin B complex: a randomised controlled trial. 61
16926172 2006
35
Alcoholic neuropathy. 61
16969158 2006
36
[The tebantin use in the complex therapy of pain syndrome during the mixed forms of alcoholic polyneuropathy]. 61
17236668 2006
37
Poisoning or primary nervous system disease?--difficulties of the differential diagnosis exemplified by four different clinical cases. 61
16225102 2005
38
Resolution of alcoholic neuropathy following liver transplantation. 61
15558589 2004
39
Alcoholic neuropathy is clinicopathologically distinct from thiamine-deficiency neuropathy. 61
12838517 2003
40
[Neurologic sequelae of chronic alcoholism]. 61
12666505 2003
41
Current perception threshold and sympathetic skin response in diabetic and alcoholic polyneuropathies. 61
12413002 2002
42
[Disulfiram neuropathy. Report of 3 cases]. 61
12434653 2002
43
T-wave response: a sensitive test for latent alcoholic polyneuropathy. 61
12126491 2002
44
Pathogenesis of alcoholic neuropathy. 61
12061083 2002
45
[Electroneuromyographic criteria of partial motor conduction block and temporal dispersion in patients with alcoholic polyneuropathy]. 61
11842623 2002
46
Alcoholic polyneuropathy: a clinical and epidemiological study. 61
11524304 2001
47
[Alcohol polyneuropathy]. 61
11584682 2001
48
Painful alcoholic polyneuropathy with predominant small-fiber loss and normal thiamine status. 61
11425941 2001
49
[Bendotiamine efficacy in alcoholic polyneuropathy therapy]. 61
11811123 2001
50
Key role for the epsilon isoform of protein kinase C in painful alcoholic neuropathy in the rat. 61
11069970 2000

Variations for Alcoholic Neuropathy

Expression for Alcoholic Neuropathy

Search GEO for disease gene expression data for Alcoholic Neuropathy.

Pathways for Alcoholic Neuropathy

GO Terms for Alcoholic Neuropathy

Cellular components related to Alcoholic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.28 UROS TKT THTPA NECAB1 NAA50 MIDN

Biological processes related to Alcoholic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ethanol oxidation GO:0006069 8.96 ALDH2 ADH4
2 alcohol metabolic process GO:0006066 8.62 ALDH2 ADH4

Molecular functions related to Alcoholic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NAD binding GO:0051287 9.16 ALDH2 ADH4
2 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0016620 8.96 ALDH2 ADH4
3 cofactor binding GO:0048037 8.62 UROS TKT

Sources for Alcoholic Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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