MCID: ALC005
MIFTS: 37

Alcoholic Pancreatitis

Categories: Endocrine diseases

Aliases & Classifications for Alcoholic Pancreatitis

MalaCards integrated aliases for Alcoholic Pancreatitis:

Name: Alcoholic Pancreatitis 12 15 17
Pancreatitis, Alcoholic 44 72
Pancreatitis Alcoholic 55

Classifications:



External Ids:

Disease Ontology 12 DOID:4988
MeSH 44 D019512
UMLS 72 C0376670

Summaries for Alcoholic Pancreatitis

MalaCards based summary : Alcoholic Pancreatitis, also known as pancreatitis, alcoholic, is related to tropical calcific pancreatitis and pancreatitis, hereditary. An important gene associated with Alcoholic Pancreatitis is SPINK1 (Serine Peptidase Inhibitor, Kazal Type 1), and among its related pathways/superpathways are Cytochrome P450 - arranged by substrate type and Drug metabolism - cytochrome P450. The drugs Dexmedetomidine and Propofol have been mentioned in the context of this disorder. Affiliated tissues include pancreas, liver and testes.

Related Diseases for Alcoholic Pancreatitis

Diseases related to Alcoholic Pancreatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Related Disease Score Top Affiliating Genes
1 tropical calcific pancreatitis 32.9 SPINK1 PRSS1
2 pancreatitis, hereditary 30.5 SPINK1 PRSS1 CFTR
3 pancreatic agenesis 1 30.1 SPINK1 SCT CFTR
4 cystic fibrosis 29.9 SPINK1 PRSS1 CFTR
5 pancreatitis 29.8 SPINK1 SCT PRSS1 CFTR CCK
6 acute pancreatitis 29.8 SPINK1 SCT CFTR CCK
7 recurrent acute pancreatitis 29.6 SPINK1 SCT PRSS1 CFTR
8 methanol poisoning 29.3 CYP2E1 ADH1C ADH1B
9 steatorrhea 29.2 SCT CFTR CCK
10 liver cirrhosis 29.1 CYP2E1 ALDH2 ADH1C ADH1B
11 duodenal ulcer 28.8 SCT CCK
12 exocrine pancreatic insufficiency 28.6 SPINK1 SCT CFTR CCK
13 pancreatic cancer 28.5 SPINK1 SCT PRSS1 CCK
14 pancreas disease 28.5 SPINK1 SCT PRSS1 CFTR CCK
15 alcoholic liver cirrhosis 28.5 CYP2E1 ALDH2 ADH1C ADH1B
16 alcohol dependence 28.4 CYP2E1 CCK ALDH2 ADH1C ADH1B
17 alcohol use disorder 10.4
18 autoimmune pancreatitis 10.3 PRSS1 CFTR
19 duodenal atresia 10.2 SCT CFTR
20 aspartylglucosaminuria 10.1 ADH1C ADH1B
21 sister chromatid exchange, frequency of 10.1 CYP2E1 ALDH2
22 liver disease 10.1
23 fetal alcohol syndrome 10.0 ALDH2 ADH1B
24 gallbladder disease 1 10.0
25 alcoholic hepatitis 10.0
26 cholangitis 10.0
27 hypertriglyceridemia, familial 9.9
28 cholestasis 9.9
29 esophageal disease 9.9 ALDH2 ADH1B
30 obstructive jaundice 9.9
31 dyspepsia 9.9
32 pancreatic adenocarcinoma 9.9
33 ileus 9.9
34 diabetes mellitus 9.9
35 biliary tract disease 9.9
36 biliary dyskinesia 9.8 SCT CCK
37 duodenogastric reflux 9.8 SCT CCK
38 pancreatic cholera 9.7 SCT CCK
39 duodenal gastrinoma 9.7 SCT CCK
40 cardiac conduction defect 9.7
41 fibrosis of extraocular muscles, congenital, 1 9.7
42 hemochromatosis, type 1 9.7
43 ocular motor apraxia 9.7
44 mental retardation, skeletal dysplasia, and abducens palsy 9.7
45 helicobacter pylori infection 9.7
46 yemenite deaf-blind hypopigmentation syndrome 9.7
47 gastrointestinal ulceration, recurrent, with dysfunctional platelets 9.7
48 cholelithiasis 9.7
49 parotitis 9.7
50 osteomalacia 9.7

Graphical network of the top 20 diseases related to Alcoholic Pancreatitis:



Diseases related to Alcoholic Pancreatitis

Symptoms & Phenotypes for Alcoholic Pancreatitis

Drugs & Therapeutics for Alcoholic Pancreatitis

Drugs for Alcoholic Pancreatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 52)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
2
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
3 Analgesics Phase 4
4 Neurotransmitter Agents Phase 4
5 Adrenergic alpha-2 Receptor Agonists Phase 4
6 Adrenergic Agonists Phase 4
7 Adrenergic alpha-Agonists Phase 4
8 Peripheral Nervous System Agents Phase 4
9 Analgesics, Non-Narcotic Phase 4
10 Central Nervous System Depressants Phase 4
11 Hypnotics and Sedatives Phase 4
12 Adrenergic Agents Phase 4
13
Pentoxifylline Approved, Investigational Phase 3 6493-05-6 4740
14
Adenosine Approved, Investigational Phase 3 58-61-7 60961
15
Selenium Approved, Investigational, Vet_approved Phase 3 7782-49-2
16
Tocopherol Approved, Investigational Phase 3 1406-66-2, 54-28-4 14986
17
Vitamin E Approved, Nutraceutical, Vet_approved Phase 3 59-02-9 14985
18
Methionine Approved, Nutraceutical Phase 3 63-68-3 6137
19
Vitamin C Approved, Nutraceutical Phase 3 50-81-7 54670067 5785
20
Beta carotene Approved, Nutraceutical Phase 3 7235-40-7
21 Tocotrienol Investigational Phase 3 6829-55-6
22 Free Radical Scavengers Phase 3
23 Antioxidants Phase 3
24 Phosphodiesterase Inhibitors Phase 3
25 Protective Agents Phase 3
26 Radiation-Protective Agents Phase 3
27 Platelet Aggregation Inhibitors Phase 3
28 Vasodilator Agents Phase 3
29 Vitamins Phase 3
30 Carotenoids Phase 3
31 Tocopherols Phase 3
32 Tocotrienols Phase 3
33
Ethanol Approved 64-17-5 702
34
Pancrelipase Approved, Investigational 53608-75-6
35
Ergocalciferol Approved, Nutraceutical 50-14-6 5280793
36
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
37
Calcium Approved, Nutraceutical 7440-70-2 271
38 Pancreatic Polypeptide Investigational 59763-91-6
39 pancreatin
40 Pharmaceutical Solutions
41 Gastrointestinal Agents
42 Micronutrients
43 Hormones
44 Ergocalciferols
45 Nutrients
46 Vitamin D2
47 Trace Elements
48 Calciferol
49 Calcium, Dietary
50 Bone Density Conservation Agents

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Dexmedetomidine vs Placebo in ERCP Sedation.A Randomized Pilot Study Completed NCT01070680 Phase 4 Precedex;sodium chlorid 0,9%
2 Pentoxifylline Treatment in Acute Pancreatitis: A Double-Blind Placebo - Controlled Randomized Trial Completed NCT02487225 Phase 3 Pentoxifylline;Placebo
3 Effect of Antioxidant Supplementation on Pain, Antioxidant Profile and Oxidative Stress in Patients With Chronic Pancreatitis Completed NCT00319358 Phase 3
4 Recurrence of Acute Alcoholic Pancreatitis Completed NCT00523874
5 Randomized Clinical Trial of the Effect of Standard Versus Intensive Intervention Protocol in Attempting to Reduce Recurrent Episodes of Acute Alcoholic Pancreatitis Completed NCT00534534
6 CT Perfusion of Pancreatic Cancer and Chronic Pancreatitis: Feasibility Study Completed NCT00588367
7 Moderate Versus Aggressive Fluid Therapy in Patient With Mild to Moderate Acute Pancratitis Completed NCT01761539
8 Pentoxifylline Treatment in Acute Pancreatitis; A Double-Blind Placebo-Controlled Randomized Trial Completed NCT01292005 Early Phase 1 Pentoxifylline;Placebo
9 The Effect of Vitamin D Substitution on Pancreatic Parenchyma and Development of Fibrosis After First Acute Alcoholic Pancreatitis: A Randomized Prospective Trial Recruiting NCT02965898
10 Assay for the Pancreatic Polypeptide: an Help for Clinical Practice Guidelines in Classification of the Diabetes Recruiting NCT03396146
11 Molecular Adsorbent Recirculating System (MARS) in Severe Acute Pancreatitis Suspended NCT00483912

Search NIH Clinical Center for Alcoholic Pancreatitis

Cochrane evidence based reviews: pancreatitis, alcoholic

Genetic Tests for Alcoholic Pancreatitis

Anatomical Context for Alcoholic Pancreatitis

MalaCards organs/tissues related to Alcoholic Pancreatitis:

41
Pancreas, Liver, Testes, Bone, Colon, Heart, Spleen

Publications for Alcoholic Pancreatitis

Articles related to Alcoholic Pancreatitis:

(show top 50) (show all 910)
# Title Authors PMID Year
1
Association analyses of genetic polymorphisms of GSTM1, GSTT1, NQO1, NAT2, LPL, PRSS1, PSTI, and CFTR with chronic alcoholic pancreatitis in Japan. 9 38
18986377 2010
2
Morphological and functional evaluation of the pancreatic duct with secretin-stimulated magnetic resonance cholangiopancreatography in alcoholic pancreatitis patients. 9 38
18470615 2008
3
Individual susceptibility to alcoholic pancreatitis. 9 38
18336667 2008
4
A novel SPINK1 gene mutation, c.206C>T, in a Thai patient with chronic alcoholic pancreatitis. 9 38
18182741 2008
5
Alcohol/cholecystokinin-evoked pancreatic acinar basolateral exocytosis is mediated by protein kinase C alpha phosphorylation of Munc18c. 9 38
17324928 2007
6
[Impairment of humoral regulation of exocrine pancreatic function in chronic pancreatitis]. 9 38
17460968 2007
7
[Genetic polymorphisms of alcohol-metabolizing enzymes and cytokines in patients with alcohol induced pancreatitis and alcoholic liver cirrhosis]. 9 38
15220553 2004
8
Mechanisms of alcoholic pancreatitis. Proceedings of a conference. Chicago, Illinois, USA, November 2002. 9 38
14576487 2003
9
Mutations of the CFTR gene in pancreatic disease. 9 38
14576497 2003
10
Role of alcohol metabolism in alcoholic pancreatitis. 9 38
14576493 2003
11
Animal and in vitro models of alcoholic pancreatitis: role of cholecystokinin. 9 38
14576490 2003
12
Limited contribution of the SPINK1 N34S mutation to the risk and severity of alcoholic chronic pancreatitis: a report from the United States. 9 38
12822871 2003
13
Study of polymorphisms in the CYP2E1 gene in patients with alcoholic pancreatitis. 9 38
11331106 2001
14
Alcohol and aldehyde dehydrogenase polymorphisms in Japanese patients with alcohol-induced chronic pancreatitis. 9 38
11117576 2000
15
Cholecystokinin in acute alcoholic and biliary pancreatitis. 9 38
11185710 2000
16
Genotypes of alcohol-metabolizing enzymes in relation to alcoholic chronic pancreatitis in Japan. 9 38
10235286 1999
17
Alcoholic pancreatitis and polymorphisms of the variable length polythymidine tract in the cystic fibrosis gene. 9 38
10195826 1999
18
Alcoholism and alcoholic organ damage and genetic polymorphisms of alcohol metabolizing enzymes in Chinese patients. 9 38
8985275 1997
19
Genotypes of alcohol-metabolizing enzymes and the risk for alcoholic chronic pancreatitis in Japanese alcoholics. 9 38
8986224 1996
20
Serum pancreas-specific protein in acute pancreatitis. Its clinical utility in comparison with serum amylase. 9 38
7510410 1994
21
Comparative study of the outcome between alcohol and gallstone pancreatitis in a high-volume tertiary care center. 38
31406928 2019
22
Patterns of alcohol consumption and nutrition intake in patients with alcoholic liver disease and alcoholic pancreatitis in North Indian men. 38
31406925 2019
23
Splenic artery pseudoaneurysm presenting with massive rectal bleeding. 38
31011381 2019
24
Does Etiology of Pancreatitis Matter? Differences in Outcomes Among Patients With Post-Endoscopic Retrograde Cholangiopancreatography, Acute Biliary, and Alcoholic Pancreatitis. 38
30946237 2019
25
Black pleural effusion caused by pancreatic pseudocyst rupture. 38
30847213 2019
26
Predicting the efficacy of surgery for pain relief in patients with alcoholic chronic pancreatitis. 38
30029988 2018
27
Extracorporeal shock wave lithotripsy for pancreatic duct stones: an observational study. 38
30353766 2018
28
Identification of risk factors for pancreatic pseudocysts formation, intervention and recurrence: a 15-year retrospective analysis in a tertiary hospital in China. 38
30285639 2018
29
Myths and realities about alcohol and smoking in chronic pancreatitis. 38
29965868 2018
30
[Clinical study of no necrotic cavity lavage after debridement and drainage in patients with infected pancreatic necrosis]. 38
30032532 2018
31
Prevalence of inflammatory bowel disease in alcoholic, non-alcoholic and autoimmune pancreatitis. 38
29734447 2018
32
Analysis of influencing factors of severity in acute pancreatitis using big data mining. 38
30304146 2018
33
Pancreatic exocrine insufficiency following acute pancreatitis: Systematic review and study level meta-analysis. 38
29482892 2018
34
Genetic polymorphism in cytochrome P450 2E1 and alcoholic pancreatitis sus-ceptibility: a meta-analysis. 38
31217677 2018
35
Characterization of intestinal microbiota in alcoholic patients with and without alcoholic hepatitis or chronic alcoholic pancreatitis. 38
29555983 2018
36
Epidemiology and Etiology of Acute Pancreatitis in Urban and Suburban Areas in Shanghai: A Retrospective Study. 38
30158961 2018
37
Intramural duodenal hematoma secondary to pancreatitis: case report and review of the literature. 38
29236933 2018
38
Endovascular treatment of pseudoaneurysms secondary to chronic pancreatitis: reports of two cases. 38
29930685 2018
39
The Combination of Alcohol and Cigarette Smoke Induces Endoplasmic Reticulum Stress and Cell Death in Pancreatic Acinar Cells. 38
28847752 2017
40
Hospital contacts with alcohol problems prior to liver cirrhosis or pancreatitis diagnosis. 38
29359016 2017
41
Prevalence and Incidence of Autoimmune Pancreatitis in the Population Living in the Southwest of Germany. 38
28957814 2017
42
The lifestyle influence on alcoholic pancreatitis versus alcoholic liver disease: a case-control study. 38
28830264 2017
43
Genetic Variants in the Manganese Superoxide Dismutase 2 Gene and in the Catalase Gene are not Associated With Alcoholic Chronic Pancreatitis. 38
28655148 2017
44
Acute pancreatitis: A 7 year retrospective cohort study of the epidemiology, aetiology and outcome from a tertiary hospital in Jamaica. 38
28808565 2017
45
The Intensity of Brief Interventions in Patients with Acute Alcoholic Pancreatitis Should be Increased, Especially in Young Patients with Heavy Alcohol Consumption. 38
28419179 2017
46
Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis. 38
28714907 2017
47
Recurrent Pleural Effusion Secondary to a Pancreatic-Pleural Fistula Treated Endoscopically. 38
28676624 2017
48
Agenesis of the dorsal pancreas associated with mucinous cysts and chronic calcific non-alcoholic pancreatitis. 38
28247770 2017
49
Dual drainage using a percutaneous pancreatic duct technique contributed to resolution of severe acute pancreatitis. 38
28236277 2017
50
Case report and systematic literature review of a novel etiology of sinistral portal hypertension presenting with UGI bleeding: Left gastric artery pseudoaneurysm compressing the splenic vein treated by embolization of the pseudoaneurysm. 38
28353569 2017

Variations for Alcoholic Pancreatitis

Expression for Alcoholic Pancreatitis

Search GEO for disease gene expression data for Alcoholic Pancreatitis.

Pathways for Alcoholic Pancreatitis

Pathways related to Alcoholic Pancreatitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.8 NQO2 CYP2E1 ALDH2 ADH1C ADH1B
2
Show member pathways
12.46 CYP2E1 ALDH2 ADH1C ADH1B
3
Show member pathways
12.23 ALDH2 ADH1C ADH1B
4
Show member pathways
11.56 CYP2E1 ALDH2 ADH1B
5
Show member pathways
10.62 ALDH2 ADH1C ADH1B
6
Show member pathways
10.54 ALDH2 ADH1B
7 10.44 ADH1C ADH1B
8
Show member pathways
10.3 CYP2E1 ADH1B
9 10 SCT CCK
10
Show member pathways
9.98 CYP2E1 ALDH2 ADH1B

GO Terms for Alcoholic Pancreatitis

Biological processes related to Alcoholic Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.35 NQO2 CYP2E1 ALDH2 ADH1C ADH1B
2 digestion GO:0007586 9.26 PRSS1 CCK
3 sperm capacitation GO:0048240 9.16 SPINK1 CFTR
4 ethanol oxidation GO:0006069 8.8 ALDH2 ADH1C ADH1B

Molecular functions related to Alcoholic Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.02 NQO2 CYP2E1 ALDH2 ADH1C ADH1B
2 alcohol dehydrogenase activity, zinc-dependent GO:0004024 8.96 ADH1C ADH1B

Sources for Alcoholic Pancreatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
Content
Loading form....