MCID: ALC005
MIFTS: 38

Alcoholic Pancreatitis

Categories: Endocrine diseases

Aliases & Classifications for Alcoholic Pancreatitis

MalaCards integrated aliases for Alcoholic Pancreatitis:

Name: Alcoholic Pancreatitis 12 15
Pancreatitis, Alcoholic 44 73
Pancreatitis Alcoholic 55

Classifications:



External Ids:

Disease Ontology 12 DOID:4988
MeSH 44 D019512
UMLS 73 C0376670

Summaries for Alcoholic Pancreatitis

MalaCards based summary : Alcoholic Pancreatitis, also known as pancreatitis, alcoholic, is related to tropical calcific pancreatitis and pancreatitis. An important gene associated with Alcoholic Pancreatitis is SPINK1 (Serine Peptidase Inhibitor, Kazal Type 1), and among its related pathways/superpathways are Cytochrome P450 - arranged by substrate type and superpathway of tryptophan utilization. The drugs Propofol and Dexmedetomidine have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and bone.

Related Diseases for Alcoholic Pancreatitis

Diseases related to Alcoholic Pancreatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 tropical calcific pancreatitis 32.3 PRSS1 SPINK1
2 pancreatitis 30.5 CCK CFTR LPL PRSS1 SCT SPINK1
3 recurrent acute pancreatitis 30.1 CFTR LPL PRSS1 SCT SPINK1
4 liver cirrhosis 29.5 ADH1B ALDH2 CYP2E1
5 cystic fibrosis 29.5 CFTR PRSS1 SCT SPINK1
6 alcoholic liver cirrhosis 29.3 ADH1B ALDH2 CYP2E1
7 alcohol abuse 29.3 ALDH2 CYP2E1
8 pancreatic cancer 29.3 CCK PRSS1 SCT SPINK1
9 duodenal ulcer 29.2 CCK SCT
10 alcohol dependence 28.9 ADH1B ALDH2 CCK CYP2E1
11 acute pancreatitis 28.8 CCK CFTR LPL SCT SPINK1
12 autoimmune pancreatitis 10.1 CFTR PRSS1
13 methanol poisoning 10.1 ADH1B CYP2E1
14 duodenal atresia 10.1 CFTR SCT
15 pancreatitis, hereditary 10.1 CFTR PRSS1 SPINK1
16 sister chromatid exchange, frequency of 10.0 ALDH2 CYP2E1
17 pancreatic agenesis 1 10.0 CFTR SCT SPINK1
18 fetal alcohol syndrome 10.0 ADH1B ALDH2
19 esophageal disease 9.9 ADH1B ALDH2
20 biliary dyskinesia 9.9 CCK SCT
21 liver disease 9.9
22 duodenogastric reflux 9.9 CCK SCT
23 pancreatic cholera 9.9 CCK SCT
24 duodenal disease 9.9 CCK SCT
25 duodenal gastrinoma 9.9 CCK SCT
26 space motion sickness 9.9 CCK SCT
27 gallbladder disease 9.9 CCK CFTR
28 maturity-onset diabetes of the young, type 7 9.9 CCK SCT
29 hepatitis 9.8
30 steatorrhea 9.8 CCK CFTR SCT
31 pancreatic steatorrhea 9.8 CCK PRSS1 SCT
32 morbid obesity 9.7 CCK LPL
33 exocrine pancreatic insufficiency 9.7 CCK CFTR SCT SPINK1
34 alcoholic hepatitis 9.7
35 hepatitis b 9.7
36 thrombosis 9.7
37 parotitis 9.7
38 hemopericardium 9.7
39 pericardial effusion 9.7
40 wernicke encephalopathy 9.7
41 thrombophilia 9.7
42 adenocarcinoma 9.7
43 encephalopathy 9.7
44 pancreas disease 9.6 CCK CFTR PRSS1 SCT SPINK1

Graphical network of the top 20 diseases related to Alcoholic Pancreatitis:



Diseases related to Alcoholic Pancreatitis

Symptoms & Phenotypes for Alcoholic Pancreatitis

Drugs & Therapeutics for Alcoholic Pancreatitis

Drugs for Alcoholic Pancreatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
2
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
3 Central Nervous System Depressants Phase 4
4 Adrenergic alpha-Agonists Phase 4
5 Adrenergic alpha-2 Receptor Agonists Phase 4
6 Analgesics Phase 4
7 Adrenergic Agents Phase 4
8 Hypnotics and Sedatives Phase 4
9 Adrenergic Agonists Phase 4
10 Peripheral Nervous System Agents Phase 4
11 Neurotransmitter Agents Phase 4
12 Analgesics, Non-Narcotic Phase 4
13
Pentoxifylline Approved, Investigational Phase 3,Early Phase 1 6493-05-6 4740
14
Adenosine Approved, Investigational Phase 3 58-61-7 60961
15 Vasodilator Agents Phase 3,Early Phase 1
16 Phosphodiesterase Inhibitors Phase 3,Early Phase 1
17 Radiation-Protective Agents Phase 3,Early Phase 1
18 Antioxidants Phase 3,Early Phase 1
19 Protective Agents Phase 3,Early Phase 1
20 Platelet Aggregation Inhibitors Phase 3,Early Phase 1
21 Free Radical Scavengers Phase 3,Early Phase 1
22
Ethanol Approved Not Applicable 64-17-5 702
23
Pancrelipase Approved, Investigational 53608-75-6
24
Ergocalciferol Approved, Nutraceutical Not Applicable 50-14-6 5280793
25
Vitamin D Approved, Nutraceutical, Vet_approved Not Applicable 1406-16-2
26 pancreatin
27 Micronutrients Not Applicable
28 Ergocalciferols Not Applicable
29 Trace Elements Not Applicable
30 Vitamins Not Applicable
31 Bone Density Conservation Agents Not Applicable
32 Calciferol Not Applicable
33 Vitamin D2 Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Dexmedetomidine Versus Placebo in Endoscopic Retrograde Cholangiopancreatography (ERCP) Sedation Completed NCT01070680 Phase 4 Precedex;sodium chlorid 0,9%
2 Pentoxifylline Treatment in Acute Pancreatitis (AP) Completed NCT02487225 Phase 3 Pentoxifylline;Placebo
3 Recurrence of Acute Alcoholic Pancreatitis Completed NCT00523874
4 Decrease of Recurrent Pancreatitis Completed NCT00534534 Not Applicable
5 Helicobacter Pylori and Acute Alcohol Induced Pancreatitis Completed NCT00490386
6 Pentoxifylline Treatment of Acute Pancreatitis Completed NCT01292005 Early Phase 1 Pentoxifylline;Placebo
7 CT Pancreas Perfusion Completed NCT00588367
8 The Effect of Vitamin D Substitution on the Development of Chronic Pancreatitis Recruiting NCT02965898 Not Applicable
9 Albumindialysis in Acute Pancreatitis Suspended NCT00483912 Not Applicable

Search NIH Clinical Center for Alcoholic Pancreatitis

Cochrane evidence based reviews: pancreatitis, alcoholic

Genetic Tests for Alcoholic Pancreatitis

Anatomical Context for Alcoholic Pancreatitis

MalaCards organs/tissues related to Alcoholic Pancreatitis:

41
Liver, Pancreas, Bone, Testes, Skin, Spinal Cord

Publications for Alcoholic Pancreatitis

Articles related to Alcoholic Pancreatitis:

(show top 50) (show all 262)
# Title Authors Year
1
Characterization of intestinal microbiota in alcoholic patients with and without alcoholic hepatitis or chronic alcoholic pancreatitis. ( 29555983 )
2018
2
Agenesis of the dorsal pancreas associated with mucinous cysts and chronic calcific non-alcoholic pancreatitis. ( 28247770 )
2017
3
Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis. ( 28714907 )
2017
4
The Long-term Prospective Follow-up of Pancreatic Function After the First Episode of Acute Alcoholic Pancreatitis: Recurrence Predisposes One to Pancreatic Dysfunction and Pancreatogenic Diabetes. ( 28060789 )
2017
5
Severity and outcomes of acute alcoholic pancreatitis in cannabis users. ( 28815220 )
2017
6
The Intensity of Brief Interventions in Patients with Acute Alcoholic Pancreatitis Should be Increased, Especially in Young Patients with Heavy Alcohol Consumption. ( 28419179 )
2017
7
The lifestyle influence on alcoholic pancreatitis versus alcoholic liver disease: a case-control study. ( 28830264 )
2017
8
Purtscher's-like retinopathy in acute alcoholic pancreatitis. ( 27628016 )
2016
9
Purtscher-like retinopathy in acute alcoholic pancreatitis. ( 27433040 )
2016
10
Alcoholic pancreatitis: New insights into the pathogenesis and treatment. ( 26909228 )
2016
11
Genetically Determined Chronic Pancreatitis but not Alcoholic Pancreatitis Is a Strong Risk Factor for Pancreatic Cancer. ( 27518468 )
2016
12
Hemosuccus pancreaticus caused by rupture of a splenic artery pseudoaneurysm complicating chronic alcoholic pancreatitis: an uncommon cause of gastrointestinal bleeding. ( 26712055 )
2015
13
Elizabethkingia miricola bacteriemia in a young woman with acute alcoholic pancreatitis. ( 26337359 )
2015
14
Alcoholic Pancreatitis Masquerading as Preeclampsia. ( 26375717 )
2015
15
Pharmacological attenuation of chronic alcoholic pancreatitis induced hypersensitivity in rats. ( 25624717 )
2015
16
Polymorphism of Alcohol Metabolizing Gene ADH3 Predisposes to Development of Alcoholic Pancreatitis in North Indian Population. ( 26734614 )
2015
17
Pancreatic morphological changes in long-term follow-up after initial episode of acute alcoholic pancreatitis. ( 24002755 )
2014
18
Alcoholic pancreatitis: A tale of spirits and bacteria. ( 24891979 )
2014
19
Should pancreatectomy with islet cell autotransplantation in patients with chronic alcoholic pancreatitis be abandoned? ( 23521936 )
2013
20
Sex and age differences in alcoholic pancreatitis in Japan: a multicenter nationwide survey. ( 23508016 )
2013
21
Effects of oxidative alcohol metabolism on the mitochondrial permeability transition pore and necrosis in a mouse model of alcoholic pancreatitis. ( 23103769 )
2013
22
Is alcoholic pancreatitis associated with enteroviral infection? ( 23840120 )
2013
23
Necro-inflammatory response of pancreatic acinar cells in the pathogenesis of acute alcoholic pancreatitis. ( 24091659 )
2013
24
Stellate cell activation in tropical calcific pancreatitis compared to alcoholic pancreatitis, adenocarcinoma of pancreas and normal pancreas. ( 22797393 )
2012
25
Extrahepatic portal venous system thrombosis in recurrent acute and chronic alcoholic pancreatitis is caused by local inflammation and not thrombophilia. ( 22825367 )
2012
26
Serum proinflammatory cytokine levels and white blood cell differential count in patients with different degrees of severity of acute alcoholic pancreatitis. ( 22763297 )
2012
27
Smoking and the course of recurrent acute and chronic alcoholic pancreatitis: a dose-dependent relationship. ( 23086245 )
2012
28
Low plasma antibodies specific for phosphatidylethanol in alcohol abusers and patients with alcoholic pancreatitis. ( 21309928 )
2012
29
Alcoholic pancreatitis and midgut malrotation. ( 22880504 )
2012
30
Investigating the pathobiology of alcoholic pancreatitis. ( 21284675 )
2011
31
Recent advances in the epidemiology of alcoholic pancreatitis. ( 21243451 )
2011
32
Anthropometric measurements of nutritional status in chronic pancreatitis in India: comparison of tropical and alcoholic pancreatitis. ( 21509539 )
2011
33
Alcoholic pancreatitis complicated by an intra-abdominal abscess. ( 21443884 )
2011
34
Alcoholic pancreatitis: lessons from the liver. ( 20238397 )
2010
35
Fatty acid composition of plasma lipid classes in chronic alcoholic pancreatitis. ( 20980776 )
2010
36
Electronic clinical challenges and images in GI. A simple case of alcoholic pancreatitis. ( 20347040 )
2010
37
Mechanisms of alcoholic pancreatitis. ( 21091991 )
2010
38
Beer and its non-alcoholic compounds: role in pancreatic exocrine secretion, alcoholic pancreatitis and pancreatic carcinoma. ( 20617020 )
2010
39
Effects of gadolinium chloride and glycine on hepatic and pancreatic tissue damage in alcoholic pancreatitis. ( 19924020 )
2010
40
New insights into alcoholic pancreatitis and pancreatic cancer. ( 19799699 )
2009
41
Pancreatic damage after the first episode of acute alcoholic pancreatitis and its association with the later recurrence rate. ( 19407478 )
2009
42
Pancreas: alcoholic pancreatitis--it's the alcohol, stupid. ( 19494819 )
2009
43
Striving for abstinence in alcoholic pancreatitis: act of humanity, economic necessity, or flogging a dead horse after all? ( 19171144 )
2009
44
Ascites with Strongyloides stercoralis in a patient with acute alcoholic pancreatitis and liver cirrhosis. ( 19795035 )
2009
45
Alcoholic pancreatitis: pathogenesis, incidence and treatment with special reference to the associated pain. ( 20049222 )
2009
46
Intraosseous fat necrosis associated with alcoholic pancreatitis. ( 26192800 )
2009
47
Individual susceptibility to alcoholic pancreatitis. ( 18336667 )
2008
48
Alcoholic pancreatitis: new pathogenetic insights. ( 18663346 )
2008
49
A novel SPINK1 gene mutation, c.206C>T, in a Thai patient with chronic alcoholic pancreatitis. ( 18182741 )
2008
50
Endotoxin as a trigger of alcoholic pancreatitis. ( 18242233 )
2008

Variations for Alcoholic Pancreatitis

Expression for Alcoholic Pancreatitis

Search GEO for disease gene expression data for Alcoholic Pancreatitis.

Pathways for Alcoholic Pancreatitis

Pathways related to Alcoholic Pancreatitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.76 ADH1B ALDH2 CYP2E1 NQO2
2
Show member pathways
11.74 ADH1B ALDH2 CYP2E1
3 11.22 ALDH2 LPL
4 11.05 CYP2E1 LPL
5
Show member pathways
10.86 ADH1B ALDH2
6
Show member pathways
10.43 ADH1B ALDH2
7
Show member pathways
10.2 ADH1B CYP2E1
8
Show member pathways
9.98 ADH1B ALDH2 CYP2E1
9 9.8 CCK SCT

GO Terms for Alcoholic Pancreatitis

Cellular components related to Alcoholic Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 CCK LPL PRSS1 SCT SPINK1

Biological processes related to Alcoholic Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.62 ADH1B ALDH2 CYP2E1 NQO2
2 triglyceride metabolic process GO:0006641 9.26 CYP2E1 LPL
3 digestion GO:0007586 9.16 CCK PRSS1
4 sperm capacitation GO:0048240 8.96 CFTR SPINK1
5 ethanol oxidation GO:0006069 8.62 ADH1B ALDH2

Molecular functions related to Alcoholic Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 8.92 ADH1B ALDH2 CYP2E1 NQO2

Sources for Alcoholic Pancreatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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