MCID: ALC005
MIFTS: 38

Alcoholic Pancreatitis

Categories: Endocrine diseases

Aliases & Classifications for Alcoholic Pancreatitis

MalaCards integrated aliases for Alcoholic Pancreatitis:

Name: Alcoholic Pancreatitis 12 15 17
Pancreatitis, Alcoholic 45 74
Pancreatitis Alcoholic 56

Classifications:



External Ids:

Disease Ontology 12 DOID:4988
MeSH 45 D019512
UMLS 74 C0376670

Summaries for Alcoholic Pancreatitis

MalaCards based summary : Alcoholic Pancreatitis, also known as pancreatitis, alcoholic, is related to tropical calcific pancreatitis and pancreatitis. An important gene associated with Alcoholic Pancreatitis is SPINK1 (Serine Peptidase Inhibitor, Kazal Type 1), and among its related pathways/superpathways are Cytochrome P450 - arranged by substrate type and Drug metabolism - cytochrome P450. The drugs Dexmedetomidine and Propofol have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and bone.

Related Diseases for Alcoholic Pancreatitis

Diseases related to Alcoholic Pancreatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 tropical calcific pancreatitis 32.5 PRSS1 SPINK1
2 pancreatitis 30.4 CCK CFTR PRSS1 SCT SPINK1
3 recurrent acute pancreatitis 30.2 CFTR PRSS1 SCT SPINK1
4 cystic fibrosis 29.6 CFTR PRSS1 SPINK1
5 liver cirrhosis 29.3 ADH1B ADH1C ALDH2 CYP2E1
6 acute pancreatitis 29.3 CCK CFTR SCT SPINK1
7 alcohol abuse 29.0 ALDH2 CYP2E1
8 pancreatic cancer 29.0 CCK PRSS1 SCT SPINK1
9 duodenal ulcer 29.0 CCK SCT
10 alcoholic liver cirrhosis 28.9 ADH1B ADH1C ALDH2 CYP2E1
11 alcohol dependence 28.1 ADH1B ADH1C ALDH2 CCK CYP2E1
12 autoimmune pancreatitis 10.2 CFTR PRSS1
13 duodenal atresia 10.1 CFTR SCT
14 pancreatitis, hereditary 10.1 CFTR PRSS1 SPINK1
15 aspartylglucosaminuria 10.1 ADH1B ADH1C
16 sister chromatid exchange, frequency of 10.0 ALDH2 CYP2E1
17 fetal alcohol syndrome 10.0 ADH1B ALDH2
18 pancreatic agenesis 1 10.0 CFTR SCT SPINK1
19 esophageal disease 9.9 ADH1B ALDH2
20 liver disease 9.9
21 methanol poisoning 9.9 ADH1B ADH1C CYP2E1
22 biliary dyskinesia 9.9 CCK SCT
23 duodenogastric reflux 9.8 CCK SCT
24 pancreatic cholera 9.8 CCK SCT
25 hepatitis 9.8
26 duodenal gastrinoma 9.8 CCK SCT
27 space motion sickness 9.8 CCK SCT
28 gallbladder disease 9.8 CCK CFTR
29 maturity-onset diabetes of the young, type 7 9.8 CCK SCT
30 diabetes mellitus, noninsulin-dependent 9.7
31 alcoholic hepatitis 9.7
32 hepatitis b 9.7
33 thrombosis 9.7
34 parotitis 9.7
35 osteomalacia 9.7
36 pre-eclampsia 9.7
37 hemopericardium 9.7
38 pericardial effusion 9.7
39 allergic hypersensitivity disease 9.7
40 hemolytic-uremic syndrome 9.7
41 wernicke encephalopathy 9.7
42 thrombophilia 9.7
43 adenocarcinoma 9.7
44 compartment syndrome 9.7
45 encephalopathy 9.7
46 steatorrhea 9.7 CCK CFTR SCT
47 pancreatic steatorrhea 9.7 CCK PRSS1 SCT
48 exocrine pancreatic insufficiency 9.5 CCK CFTR SCT SPINK1
49 pancreas disease 9.3 CCK CFTR PRSS1 SCT SPINK1

Graphical network of the top 20 diseases related to Alcoholic Pancreatitis:



Diseases related to Alcoholic Pancreatitis

Symptoms & Phenotypes for Alcoholic Pancreatitis

Drugs & Therapeutics for Alcoholic Pancreatitis

Drugs for Alcoholic Pancreatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
2
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
3 Adrenergic alpha-2 Receptor Agonists Phase 4
4 Adrenergic Agents Phase 4
5 Neurotransmitter Agents Phase 4
6 Analgesics, Non-Narcotic Phase 4
7 Analgesics Phase 4
8 Central Nervous System Depressants Phase 4
9 Adrenergic Agonists Phase 4
10 Hypnotics and Sedatives Phase 4
11 Peripheral Nervous System Agents Phase 4
12 Adrenergic alpha-Agonists Phase 4
13
Adenosine Approved, Investigational Phase 3 58-61-7 60961
14
Pentoxifylline Approved, Investigational Phase 3,Early Phase 1 6493-05-6 4740
15 Free Radical Scavengers Phase 3,Early Phase 1
16 Protective Agents Phase 3,Early Phase 1
17 Phosphodiesterase Inhibitors Phase 3,Early Phase 1
18 Radiation-Protective Agents Phase 3,Early Phase 1
19 Antioxidants Phase 3,Early Phase 1
20 Vasodilator Agents Phase 3,Early Phase 1
21 Platelet Aggregation Inhibitors Phase 3,Early Phase 1
22
Ethanol Approved Not Applicable 64-17-5 702
23
Pancrelipase Approved, Investigational 53608-75-6
24
Vitamin D Approved, Nutraceutical, Vet_approved Not Applicable 1406-16-2
25
Ergocalciferol Approved, Nutraceutical Not Applicable 50-14-6 5280793
26
Calcium Approved, Nutraceutical Not Applicable 7440-70-2 271
27 pancreatin
28 Pharmaceutical Solutions Not Applicable
29 Calciferol Not Applicable
30 Vitamins Not Applicable
31 Nutrients Not Applicable
32 Bone Density Conservation Agents Not Applicable
33 Ergocalciferols Not Applicable
34 Hormones Not Applicable
35 Micronutrients Not Applicable
36 Vitamin D2 Not Applicable
37 Trace Elements Not Applicable
38 Calcium, Dietary Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Dexmedetomidine Versus Placebo in Endoscopic Retrograde Cholangiopancreatography (ERCP) Sedation Completed NCT01070680 Phase 4 Precedex;sodium chlorid 0,9%
2 Pentoxifylline Treatment in Acute Pancreatitis (AP) Completed NCT02487225 Phase 3 Pentoxifylline;Placebo
3 Recurrence of Acute Alcoholic Pancreatitis Completed NCT00523874
4 Decrease of Recurrent Pancreatitis Completed NCT00534534 Not Applicable
5 Helicobacter Pylori and Acute Alcohol Induced Pancreatitis Completed NCT00490386
6 Pentoxifylline Treatment of Acute Pancreatitis Completed NCT01292005 Early Phase 1 Pentoxifylline;Placebo
7 CT Pancreas Perfusion Completed NCT00588367
8 Moderate Versus Aggressive Fluids for Acute Pancreatitis Completed NCT01761539 Not Applicable
9 The Effect of Vitamin D Substitution on the Development of Chronic Pancreatitis Recruiting NCT02965898 Not Applicable
10 Albumindialysis in Acute Pancreatitis Suspended NCT00483912 Not Applicable

Search NIH Clinical Center for Alcoholic Pancreatitis

Cochrane evidence based reviews: pancreatitis, alcoholic

Genetic Tests for Alcoholic Pancreatitis

Anatomical Context for Alcoholic Pancreatitis

MalaCards organs/tissues related to Alcoholic Pancreatitis:

42
Liver, Pancreas, Bone, Testes, Skin, Spinal Cord

Publications for Alcoholic Pancreatitis

Articles related to Alcoholic Pancreatitis:

(show top 50) (show all 264)
# Title Authors Year
1
Does Etiology of Pancreatitis Matter? Differences in Outcomes Among Patients With Post-Endoscopic Retrograde Cholangiopancreatography, Acute Biliary, and Alcoholic Pancreatitis. ( 30946237 )
2019
2
Characterization of intestinal microbiota in alcoholic patients with and without alcoholic hepatitis or chronic alcoholic pancreatitis. ( 29555983 )
2018
3
Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis. ( 28714907 )
2017
4
The Long-term Prospective Follow-up of Pancreatic Function After the First Episode of Acute Alcoholic Pancreatitis: Recurrence Predisposes One to Pancreatic Dysfunction and Pancreatogenic Diabetes. ( 28060789 )
2017
5
Agenesis of the dorsal pancreas associated with mucinous cysts and chronic calcific non-alcoholic pancreatitis. ( 28247770 )
2017
6
The Intensity of Brief Interventions in Patients with Acute Alcoholic Pancreatitis Should be Increased, Especially in Young Patients with Heavy Alcohol Consumption. ( 28419179 )
2017
7
Severity and outcomes of acute alcoholic pancreatitis in cannabis users. ( 28815220 )
2017
8
The lifestyle influence on alcoholic pancreatitis versus alcoholic liver disease: a case-control study. ( 28830264 )
2017
9
Alcoholic pancreatitis: New insights into the pathogenesis and treatment. ( 26909228 )
2016
10
Purtscher-like retinopathy in acute alcoholic pancreatitis. ( 27433040 )
2016
11
Genetically Determined Chronic Pancreatitis but not Alcoholic Pancreatitis Is a Strong Risk Factor for Pancreatic Cancer. ( 27518468 )
2016
12
Purtscher's-like retinopathy in acute alcoholic pancreatitis. ( 27628016 )
2016
13
Pharmacological attenuation of chronic alcoholic pancreatitis induced hypersensitivity in rats. ( 25624717 )
2015
14
Elizabethkingia miricola bacteriemia in a young woman with acute alcoholic pancreatitis. ( 26337359 )
2015
15
Alcoholic Pancreatitis Masquerading as Preeclampsia. ( 26375717 )
2015
16
Hemosuccus pancreaticus caused by rupture of a splenic artery pseudoaneurysm complicating chronic alcoholic pancreatitis: an uncommon cause of gastrointestinal bleeding. ( 26712055 )
2015
17
Polymorphism of Alcohol Metabolizing Gene ADH3 Predisposes to Development of Alcoholic Pancreatitis in North Indian Population. ( 26734614 )
2015
18
Pancreatic morphological changes in long-term follow-up after initial episode of acute alcoholic pancreatitis. ( 24002755 )
2014
19
Alcoholic pancreatitis: A tale of spirits and bacteria. ( 24891979 )
2014
20
Effects of oxidative alcohol metabolism on the mitochondrial permeability transition pore and necrosis in a mouse model of alcoholic pancreatitis. ( 23103769 )
2013
21
Sex and age differences in alcoholic pancreatitis in Japan: a multicenter nationwide survey. ( 23508016 )
2013
22
Should pancreatectomy with islet cell autotransplantation in patients with chronic alcoholic pancreatitis be abandoned? ( 23521936 )
2013
23
Is alcoholic pancreatitis associated with enteroviral infection? ( 23840120 )
2013
24
Necro-inflammatory response of pancreatic acinar cells in the pathogenesis of acute alcoholic pancreatitis. ( 24091659 )
2013
25
Low plasma antibodies specific for phosphatidylethanol in alcohol abusers and patients with alcoholic pancreatitis. ( 21309928 )
2012
26
Serum proinflammatory cytokine levels and white blood cell differential count in patients with different degrees of severity of acute alcoholic pancreatitis. ( 22763297 )
2012
27
Stellate cell activation in tropical calcific pancreatitis compared to alcoholic pancreatitis, adenocarcinoma of pancreas and normal pancreas. ( 22797393 )
2012
28
Extrahepatic portal venous system thrombosis in recurrent acute and chronic alcoholic pancreatitis is caused by local inflammation and not thrombophilia. ( 22825367 )
2012
29
Alcoholic pancreatitis and midgut malrotation. ( 22880504 )
2012
30
Smoking and the course of recurrent acute and chronic alcoholic pancreatitis: a dose-dependent relationship. ( 23086245 )
2012
31
Recent advances in the epidemiology of alcoholic pancreatitis. ( 21243451 )
2011
32
Investigating the pathobiology of alcoholic pancreatitis. ( 21284675 )
2011
33
Alcoholic pancreatitis complicated by an intra-abdominal abscess. ( 21443884 )
2011
34
Anthropometric measurements of nutritional status in chronic pancreatitis in India: comparison of tropical and alcoholic pancreatitis. ( 21509539 )
2011
35
Association analyses of genetic polymorphisms of GSTM1, GSTT1, NQO1, NAT2, LPL, PRSS1, PSTI, and CFTR with chronic alcoholic pancreatitis in Japan. ( 18986377 )
2010
36
Effects of gadolinium chloride and glycine on hepatic and pancreatic tissue damage in alcoholic pancreatitis. ( 19924020 )
2010
37
Alcoholic pancreatitis: lessons from the liver. ( 20238397 )
2010
38
Electronic clinical challenges and images in GI. A simple case of alcoholic pancreatitis. ( 20347040 )
2010
39
Beer and its non-alcoholic compounds: role in pancreatic exocrine secretion, alcoholic pancreatitis and pancreatic carcinoma. ( 20617020 )
2010
40
Fatty acid composition of plasma lipid classes in chronic alcoholic pancreatitis. ( 20980776 )
2010
41
Mechanisms of alcoholic pancreatitis. ( 21091991 )
2010
42
Striving for abstinence in alcoholic pancreatitis: act of humanity, economic necessity, or flogging a dead horse after all? ( 19171144 )
2009
43
Pancreatic damage after the first episode of acute alcoholic pancreatitis and its association with the later recurrence rate. ( 19407478 )
2009
44
Pancreas: alcoholic pancreatitis--it's the alcohol, stupid. ( 19494819 )
2009
45
Ascites with Strongyloides stercoralis in a patient with acute alcoholic pancreatitis and liver cirrhosis. ( 19795035 )
2009
46
New insights into alcoholic pancreatitis and pancreatic cancer. ( 19799699 )
2009
47
Alcoholic pancreatitis: pathogenesis, incidence and treatment with special reference to the associated pain. ( 20049222 )
2009
48
Intraosseous fat necrosis associated with alcoholic pancreatitis. ( 26192800 )
2009
49
A novel SPINK1 gene mutation, c.206C>T, in a Thai patient with chronic alcoholic pancreatitis. ( 18182741 )
2008
50
Endotoxin as a trigger of alcoholic pancreatitis. ( 18242233 )
2008

Variations for Alcoholic Pancreatitis

Expression for Alcoholic Pancreatitis

Search GEO for disease gene expression data for Alcoholic Pancreatitis.

Pathways for Alcoholic Pancreatitis

Pathways related to Alcoholic Pancreatitis according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.83 ADH1B ADH1C ALDH2 CYP2E1 NQO2
2
Show member pathways
12.48 ADH1B ADH1C ALDH2 CYP2E1
3
Show member pathways
12.25 ADH1B ADH1C ALDH2
4
Show member pathways
11.58 ADH1B ALDH2 CYP2E1
5
Show member pathways
11.42 ADH1B ADH1C ALDH2
6
Show member pathways
10.62 ADH1B ADH1C ALDH2
7
Show member pathways
10.55 ADH1B ALDH2
8
Show member pathways
10.51 ADH1B ADH1C
9
Show member pathways
10.36 ADH1B CYP2E1
10 10 CCK SCT
11
Show member pathways
9.98 ADH1B ALDH2 CYP2E1

GO Terms for Alcoholic Pancreatitis

Biological processes related to Alcoholic Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.35 ADH1B ADH1C ALDH2 CYP2E1 NQO2
2 digestion GO:0007586 9.26 CCK PRSS1
3 sperm capacitation GO:0048240 9.16 CFTR SPINK1
4 ethanol oxidation GO:0006069 8.8 ADH1B ADH1C ALDH2

Molecular functions related to Alcoholic Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.02 ADH1B ADH1C ALDH2 CYP2E1 NQO2
2 alcohol dehydrogenase activity, zinc-dependent GO:0004024 8.96 ADH1B ADH1C

Sources for Alcoholic Pancreatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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