MCID: ALC005
MIFTS: 39

Alcoholic Pancreatitis

Categories: Endocrine diseases

Aliases & Classifications for Alcoholic Pancreatitis

MalaCards integrated aliases for Alcoholic Pancreatitis:

Name: Alcoholic Pancreatitis 12 15 17
Pancreatitis, Alcoholic 43 71
Pancreatitis Alcoholic 54

Classifications:



External Ids:

Disease Ontology 12 DOID:4988
MeSH 43 D019512
UMLS 71 C0376670

Summaries for Alcoholic Pancreatitis

MalaCards based summary : Alcoholic Pancreatitis, also known as pancreatitis, alcoholic, is related to tropical calcific pancreatitis and pancreatitis, hereditary. An important gene associated with Alcoholic Pancreatitis is SPINK1 (Serine Peptidase Inhibitor Kazal Type 1), and among its related pathways/superpathways are Metabolism and Cytochrome P450 - arranged by substrate type. The drugs Dexmedetomidine and Propofol have been mentioned in the context of this disorder. Affiliated tissues include pancreas, liver and testes, and related phenotype is homeostasis/metabolism.

Related Diseases for Alcoholic Pancreatitis

Diseases related to Alcoholic Pancreatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 109)
# Related Disease Score Top Affiliating Genes
1 tropical calcific pancreatitis 32.7 SPINK1 PRSS1
2 pancreatitis, hereditary 30.7 SPINK1 PRSS1 CFTR
3 pancreatic agenesis 1 30.3 SPINK1 SCT CFTR
4 alcohol use disorder 30.1 CYP2E1 ALDH2 ADH1C ADH1B
5 recurrent acute pancreatitis 29.7 SPINK1 SCT PRSS1 LPL CFTR
6 alcoholic cardiomyopathy 29.5 CYP2E1 ALDH2 ADH1B
7 alcohol dependence 29.5 CYP2E1 CCK ALDH2 ADH1C ADH1B
8 exocrine pancreatic insufficiency 29.2 SPINK1 SCT CFTR CCK
9 duodenal ulcer 29.2 SCT CCK CAT
10 methanol poisoning 29.1 CYP2E1 ALDH2 ADH1C ADH1B
11 liver cirrhosis 29.1 SCT CYP2E1 ALDH2 ADH1C ADH1B
12 pancreatic adenocarcinoma 28.8 SPINK1 SCT PRSS1 CFTR CCK
13 alcoholic liver cirrhosis 28.7 GSTM1 CYP2E1 ALDH2 ADH1C ADH1B
14 acute pancreatitis 28.6 SPINK1 SCT REG3A PRSS1 LPL CPB1
15 pancreatic cancer 28.1 SPINK1 SCT REG3A PRSS1 NQO1 CFTR
16 diabetes mellitus 27.9 SPINK1 SCT LPL CYP2E1 CCK CAT
17 pancreatitis 27.7 SPINK1 SCT REG3A PRSS1 LPL CPB1
18 duodenal obstruction 10.3 SPINK1 PRSS1
19 prss1-related hereditary pancreatitis 10.3 SPINK1 PRSS1 CFTR
20 trimethoprim allergy 10.3 GSTM1 CYP2E1
21 cystic fibrosis 10.1
22 pancreas disease 10.1
23 alcohol-related birth defect 10.1 ADH1C ADH1B
24 oligospermia 10.1 GSTP1 GSTM1 CFTR
25 alcoholic hepatitis 10.1
26 liver disease 10.1
27 cholangitis 10.1
28 cardia cancer 10.0 GSTP1 GSTM1 CYP2E1
29 acetaminophen metabolism 10.0 NQO1 GSTP1 CYP2E1
30 gallbladder disease 1 10.0
31 sister chromatid exchange, frequency of 10.0 GSTM1 CYP2E1 ALDH2
32 fetal alcohol spectrum disorder 10.0 CYP2E1 ALDH2 ADH1B
33 asbestosis 9.9 GSTP1 GSTM1 CAT
34 hypertriglyceridemia, familial 9.9
35 cholestasis 9.9
36 intestinal disaccharidase deficiency 9.9 SCT CAT
37 gastroduodenal crohn's disease 9.9 NQO1 CCK
38 colorectal adenoma 9.9 NQO1 GSTP1 GSTM1
39 substance abuse 9.9 CYP2E1 ALDH2 ADH1B
40 obstructive jaundice 9.9
41 cholecystitis 9.9
42 wernicke encephalopathy 9.9
43 ileus 9.9
44 biliary tract disease 9.9
45 cytokine deficiency 9.9
46 encephalopathy 9.9
47 pulmonary disease, chronic obstructive 9.8 GSTP1 GSTM1 CYP2E1 CFTR
48 tobacco addiction 9.8 GSTM1 CYP2E1 ALDH2 ADH1B
49 pancreatic steatorrhea 9.8 SCT PRSS1 CCK
50 bile acid malabsorption, primary 9.8 SCT CFTR CCK

Graphical network of the top 20 diseases related to Alcoholic Pancreatitis:



Diseases related to Alcoholic Pancreatitis

Symptoms & Phenotypes for Alcoholic Pancreatitis

MGI Mouse Phenotypes related to Alcoholic Pancreatitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.36 ADH1C ALDH2 CAT CCK CFTR CYP2E1

Drugs & Therapeutics for Alcoholic Pancreatitis

Drugs for Alcoholic Pancreatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
2
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
3 Central Nervous System Depressants Phase 4
4 Adrenergic Agonists Phase 4
5 Adrenergic alpha-2 Receptor Agonists Phase 4
6 Hypnotics and Sedatives Phase 4
7 Neurotransmitter Agents Phase 4
8 Analgesics, Non-Narcotic Phase 4
9 Adrenergic Agents Phase 4
10 Analgesics Phase 4
11
Adenosine Approved, Investigational Phase 3 58-61-7 60961
12
Pentoxifylline Approved, Investigational Phase 3 6493-05-6 4740
13
Tocopherol Approved, Investigational Phase 3 1406-66-2, 54-28-4 14986
14
Selenium Approved, Investigational, Vet_approved Phase 3 7782-49-2
15
Vitamin E Approved, Nutraceutical, Vet_approved Phase 3 59-02-9 14985
16
Vitamin C Approved, Nutraceutical Phase 3 50-81-7 5785 54670067
17
Methionine Approved, Nutraceutical Phase 3 63-68-3 6137
18
Beta carotene Approved, Nutraceutical Phase 3 7235-40-7
19 Tocotrienol Investigational Phase 3 6829-55-6
20 Platelet Aggregation Inhibitors Phase 3
21 Free Radical Scavengers Phase 3
22 Vasodilator Agents Phase 3
23 Antioxidants Phase 3
24 Phosphodiesterase Inhibitors Phase 3
25 Protective Agents Phase 3
26 Radiation-Protective Agents Phase 3
27 Vitamins Phase 3
28 Carotenoids Phase 3
29 Tocopherols Phase 3
30 Tocotrienols Phase 3
31
Pancrelipase Approved, Investigational 53608-75-6
32
Ethanol Approved 64-17-5 702
33
Ergocalciferol Approved, Nutraceutical 50-14-6 5280793
34
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
35
Calcium Approved, Nutraceutical 7440-70-2 271
36 Pancreatic Polypeptide Investigational 59763-91-6
37 pancreatin
38 Pharmaceutical Solutions
39 Anti-Infective Agents, Local
40 Anti-Infective Agents
41 Gastrointestinal Agents
42 Micronutrients
43 Trace Elements
44 Nutrients
45 Ergocalciferols
46 Vitamin D2
47 Calcium, Dietary
48 Calciferol
49 Hormones
50 Hormone Antagonists

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Dexmedetomidine vs Placebo in ERCP Sedation.A Randomized Pilot Study Completed NCT01070680 Phase 4 Precedex;sodium chlorid 0,9%
2 Pentoxifylline Treatment in Acute Pancreatitis: A Double-Blind Placebo - Controlled Randomized Trial Completed NCT02487225 Phase 3 Pentoxifylline;Placebo
3 Effect of Antioxidant Supplementation on Pain, Antioxidant Profile and Oxidative Stress in Patients With Chronic Pancreatitis Completed NCT00319358 Phase 3
4 Recurrence of Acute Alcoholic Pancreatitis Completed NCT00523874
5 CT Perfusion of Pancreatic Cancer and Chronic Pancreatitis: Feasibility Study Completed NCT00588367
6 Moderate Versus Aggressive Fluid Therapy in Patient With Mild to Moderate Acute Pancratitis Completed NCT01761539
7 Randomized Clinical Trial of the Effect of Standard Versus Intensive Intervention Protocol in Attempting to Reduce Recurrent Episodes of Acute Alcoholic Pancreatitis Completed NCT00534534
8 Pentoxifylline Treatment in Acute Pancreatitis; A Double-Blind Placebo-Controlled Randomized Trial Completed NCT01292005 Early Phase 1 Pentoxifylline;Placebo
9 The Effect of Vitamin D Substitution on Pancreatic Parenchyma and Development of Fibrosis After First Acute Alcoholic Pancreatitis: A Randomized Prospective Trial Recruiting NCT02965898
10 Assay for the Pancreatic Polypeptide: an Help for Clinical Practice Guidelines in Classification of the Diabetes Recruiting NCT03396146
11 Molecular Adsorbent Recirculating System (MARS) in Severe Acute Pancreatitis Suspended NCT00483912

Search NIH Clinical Center for Alcoholic Pancreatitis

Cochrane evidence based reviews: pancreatitis, alcoholic

Genetic Tests for Alcoholic Pancreatitis

Anatomical Context for Alcoholic Pancreatitis

MalaCards organs/tissues related to Alcoholic Pancreatitis:

40
Pancreas, Liver, Testes, Kidney, Heart, Colon, Bone

Publications for Alcoholic Pancreatitis

Articles related to Alcoholic Pancreatitis:

(show top 50) (show all 918)
# Title Authors PMID Year
1
Association analyses of genetic polymorphisms of GSTM1, GSTT1, NQO1, NAT2, LPL, PRSS1, PSTI, and CFTR with chronic alcoholic pancreatitis in Japan. 54 61
18986377 2010
2
Morphological and functional evaluation of the pancreatic duct with secretin-stimulated magnetic resonance cholangiopancreatography in alcoholic pancreatitis patients. 54 61
18470615 2008
3
Individual susceptibility to alcoholic pancreatitis. 54 61
18336667 2008
4
A novel SPINK1 gene mutation, c.206C>T, in a Thai patient with chronic alcoholic pancreatitis. 54 61
18182741 2008
5
Alcohol/cholecystokinin-evoked pancreatic acinar basolateral exocytosis is mediated by protein kinase C alpha phosphorylation of Munc18c. 54 61
17324928 2007
6
[Impairment of humoral regulation of exocrine pancreatic function in chronic pancreatitis]. 54 61
17460968 2007
7
[Genetic polymorphisms of alcohol-metabolizing enzymes and cytokines in patients with alcohol induced pancreatitis and alcoholic liver cirrhosis]. 54 61
15220553 2004
8
Mechanisms of alcoholic pancreatitis. Proceedings of a conference. Chicago, Illinois, USA, November 2002. 54 61
14576487 2003
9
Mutations of the CFTR gene in pancreatic disease. 54 61
14576497 2003
10
Role of alcohol metabolism in alcoholic pancreatitis. 54 61
14576493 2003
11
Animal and in vitro models of alcoholic pancreatitis: role of cholecystokinin. 54 61
14576490 2003
12
Limited contribution of the SPINK1 N34S mutation to the risk and severity of alcoholic chronic pancreatitis: a report from the United States. 54 61
12822871 2003
13
Study of polymorphisms in the CYP2E1 gene in patients with alcoholic pancreatitis. 54 61
11331106 2001
14
Alcohol and aldehyde dehydrogenase polymorphisms in Japanese patients with alcohol-induced chronic pancreatitis. 54 61
11117576 2000
15
Cholecystokinin in acute alcoholic and biliary pancreatitis. 54 61
11185710 2000
16
Genotypes of alcohol-metabolizing enzymes in relation to alcoholic chronic pancreatitis in Japan. 54 61
10235286 1999
17
Alcoholic pancreatitis and polymorphisms of the variable length polythymidine tract in the cystic fibrosis gene. 54 61
10195826 1999
18
Alcoholism and alcoholic organ damage and genetic polymorphisms of alcohol metabolizing enzymes in Chinese patients. 54 61
8985275 1997
19
Genotypes of alcohol-metabolizing enzymes and the risk for alcoholic chronic pancreatitis in Japanese alcoholics. 54 61
8986224 1996
20
Serum pancreas-specific protein in acute pancreatitis. Its clinical utility in comparison with serum amylase. 54 61
7510410 1994
21
Critical Role of TFEB-Mediated Lysosomal Biogenesis in Alcohol-Induced Pancreatitis in Mice and Humans. 61
31987928 2020
22
Lifetime Drinking History of Persons With Chronic Pancreatitis. 61
31603464 2019
23
Gut Microbiota in Alcoholic Hepatitis is Disparate from Those in Acute Alcoholic Pancreatitis and Biliary Disease. 61
31889749 2019
24
Screening of Sera from Patients with Pancreatitis by an Apoptosis Assay of Skin-derived Cells. 61
31650798 2019
25
Acute Pancreatitis: An Exploratory, Cross-sectional, Single-center Study of the Epidemiological Features of the Disease in a Sample of Saudi Patients. 61
31529932 2019
26
Patterns of alcohol consumption and nutrition intake in patients with alcoholic liver disease and alcoholic pancreatitis in North Indian men. 61
31406925 2019
27
Comparative study of the outcome between alcohol and gallstone pancreatitis in a high-volume tertiary care center. 61
31406928 2019
28
[Protective Effect of a Dihydroflavonol Glycoside from Coreopsis tinctoria Nutt. in Mouse Model of Alcoholic Acute Pancreatitis]. 61
31642231 2019
29
Splenic artery pseudoaneurysm presenting with massive rectal bleeding. 61
31011381 2019
30
Does Etiology of Pancreatitis Matter? Differences in Outcomes Among Patients With Post-Endoscopic Retrograde Cholangiopancreatography, Acute Biliary, and Alcoholic Pancreatitis. 61
30946237 2019
31
Black pleural effusion caused by pancreatic pseudocyst rupture. 61
30847213 2019
32
DIFFERENT SCORING SYSTEMS IN ACUTE ALCOHOLIC PANCREATITIS: WHICH ONE TO FOLLOW? AN ONGOING DILEMA. 61
31633726 2019
33
Structural, functional and molecular dynamics analysis of cathepsin B gene SNPs associated with tropical calcific pancreatitis, a rare disease of tropics. 61
31592339 2019
34
Predicting the efficacy of surgery for pain relief in patients with alcoholic chronic pancreatitis. 61
30029988 2018
35
Extracorporeal shock wave lithotripsy for pancreatic duct stones: an observational study. 61
30353766 2018
36
Identification of risk factors for pancreatic pseudocysts formation, intervention and recurrence: a 15-year retrospective analysis in a tertiary hospital in China. 61
30285639 2018
37
Myths and realities about alcohol and smoking in chronic pancreatitis. 61
29965868 2018
38
[Clinical study of no necrotic cavity lavage after debridement and drainage in patients with infected pancreatic necrosis]. 61
30032532 2018
39
Prevalence of inflammatory bowel disease in alcoholic, non-alcoholic and autoimmune pancreatitis. 61
29734447 2018
40
Analysis of influencing factors of severity in acute pancreatitis using big data mining. 61
30304146 2018
41
Pancreatic exocrine insufficiency following acute pancreatitis: Systematic review and study level meta-analysis. 61
29482892 2018
42
Genetic polymorphism in cytochrome P450 2E1 and alcoholic pancreatitis sus-ceptibility: a meta-analysis. 61
31217677 2018
43
Characterization of intestinal microbiota in alcoholic patients with and without alcoholic hepatitis or chronic alcoholic pancreatitis. 61
29555983 2018
44
Epidemiology and Etiology of Acute Pancreatitis in Urban and Suburban Areas in Shanghai: A Retrospective Study. 61
30158961 2018
45
Intramural duodenal hematoma secondary to pancreatitis: case report and review of the literature. 61
29236933 2018
46
Endovascular treatment of pseudoaneurysms secondary to chronic pancreatitis: reports of two cases. 61
29930685 2018
47
The Combination of Alcohol and Cigarette Smoke Induces Endoplasmic Reticulum Stress and Cell Death in Pancreatic Acinar Cells. 61
28847752 2017
48
Hospital contacts with alcohol problems prior to liver cirrhosis or pancreatitis diagnosis. 61
29359016 2017
49
Prevalence and Incidence of Autoimmune Pancreatitis in the Population Living in the Southwest of Germany. 61
28957814 2017
50
The lifestyle influence on alcoholic pancreatitis versus alcoholic liver disease: a case-control study. 61
28830264 2017

Variations for Alcoholic Pancreatitis

Expression for Alcoholic Pancreatitis

Search GEO for disease gene expression data for Alcoholic Pancreatitis.

Pathways for Alcoholic Pancreatitis

Pathways related to Alcoholic Pancreatitis according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.9 PRSS1 NQO2 NQO1 LPL GSTP1 GSTM1
2
Show member pathways
13.02 NQO2 GSTP1 GSTM1 CYP2E1 ALDH2 ADH1C
3
Show member pathways
12.64 GSTP1 GSTM1 CYP2E1 ALDH2 ADH1C ADH1B
4 11.91 NQO1 GSTP1 GSTM1
5 11.89 NQO1 GSTP1 GSTM1
6
Show member pathways
11.68 CYP2E1 CAT ALDH2
7 11.56 SCT PRSS1 CPB1 CFTR CCK
8
Show member pathways
11.52 NQO1 GSTP1 GSTM1 CYP2E1
9 11.1 NQO1 GSTP1 GSTM1
10 10.96 GSTP1 GSTM1 CYP2E1
11 10.91 NQO2 NQO1 GSTP1
12
Show member pathways
10.75 GSTP1 ALDH2 ADH1C ADH1B
13
Show member pathways
10.73 ALDH2 ADH1B
14 10.66 ADH1C ADH1B
15
Show member pathways
10.57 CYP2E1 ADH1B
16 10.34 SCT CCK
17 10.21 NQO1 GSTM1 CYP2E1
18
Show member pathways
10.1 CYP2E1 CAT ALDH2 ADH1B

GO Terms for Alcoholic Pancreatitis

Cellular components related to Alcoholic Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 SPINK1 SCT REG3A PRSS1 LPL GSTP1
2 extracellular space GO:0005615 9.28 SPINK1 SCT REG3A PRSS1 LPL GSTP1

Biological processes related to Alcoholic Pancreatitis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 response to estradiol GO:0032355 9.67 NQO1 GSTP1 CAT
2 response to toxic substance GO:0009636 9.63 NQO1 GSTP1 CAT
3 electron transport chain GO:0022900 9.61 NQO2 NQO1 ALDH2
4 response to ethanol GO:0045471 9.56 NQO1 GSTP1 CYP2E1 CAT
5 retinoic acid metabolic process GO:0042573 9.54 ADH1C ADH1B
6 sperm capacitation GO:0048240 9.52 SPINK1 CFTR
7 glutathione derivative biosynthetic process GO:1901687 9.51 GSTP1 GSTM1
8 triglyceride metabolic process GO:0006641 9.5 LPL CYP2E1 CAT
9 oxidation-reduction process GO:0055114 9.5 NQO2 NQO1 CYP2E1 CAT ALDH2 ADH1C
10 response to reactive oxygen species GO:0000302 9.48 GSTP1 CAT
11 xenobiotic metabolic process GO:0006805 9.46 NQO2 NQO1 GSTP1 CYP2E1
12 response to L-ascorbic acid GO:0033591 9.4 GSTP1 CAT
13 response to ozone GO:0010193 9.37 CYP2E1 CAT
14 ethanol oxidation GO:0006069 8.8 ALDH2 ADH1C ADH1B

Molecular functions related to Alcoholic Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.71 GSTM1 CYP2E1 CFTR CAT
2 electron transfer activity GO:0009055 9.43 NQO2 NQO1 ALDH2
3 retinol dehydrogenase activity GO:0004745 9.37 ADH1C ADH1B
4 glutathione binding GO:0043295 9.32 GSTP1 GSTM1
5 oxidoreductase activity GO:0016491 9.17 NQO2 NQO1 CYP2E1 CAT ALDH2 ADH1C
6 alcohol dehydrogenase activity, zinc-dependent GO:0004024 9.16 ADH1C ADH1B
7 NAD(P)H dehydrogenase (quinone) activity GO:0003955 8.96 NQO2 NQO1

Sources for Alcoholic Pancreatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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