MCID: ALC005
MIFTS: 40

Alcoholic Pancreatitis

Categories: Endocrine diseases

Aliases & Classifications for Alcoholic Pancreatitis

MalaCards integrated aliases for Alcoholic Pancreatitis:

Name: Alcoholic Pancreatitis 12 15 17
Pancreatitis, Alcoholic 43 71
Pancreatitis Alcoholic 54

Classifications:



External Ids:

Disease Ontology 12 DOID:4988
MeSH 43 D019512
SNOMED-CT 67 445507008
UMLS 71 C0376670

Summaries for Alcoholic Pancreatitis

MalaCards based summary : Alcoholic Pancreatitis, also known as pancreatitis, alcoholic, is related to tropical calcific pancreatitis and pancreatitis, hereditary. An important gene associated with Alcoholic Pancreatitis is SPINK1 (Serine Peptidase Inhibitor Kazal Type 1), and among its related pathways/superpathways are Metabolism and Cytochrome P450 - arranged by substrate type. The drugs Dexmedetomidine and Propofol have been mentioned in the context of this disorder. Affiliated tissues include pancreas, liver and testes, and related phenotypes are homeostasis/metabolism and neoplasm

Related Diseases for Alcoholic Pancreatitis

Diseases related to Alcoholic Pancreatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 113)
# Related Disease Score Top Affiliating Genes
1 tropical calcific pancreatitis 32.7 SPINK1 PRSS1
2 pancreatitis, hereditary 30.7 SPINK1 PRSS1 CFTR
3 pancreatic agenesis 1 30.3 SPINK1 SCT CFTR
4 alcohol use disorder 30.1 CYP2E1 ALDH2 ADH1C ADH1B
5 alcoholic cardiomyopathy 29.5 CYP2E1 ALDH2 ADH1B
6 alcohol dependence 29.5 CYP2E1 CCK ALDH2 ADH1C ADH1B
7 duodenal ulcer 29.1 SCT CCK CAT
8 methanol poisoning 29.1 CYP2E1 ALDH2 ADH1C ADH1B
9 liver cirrhosis 29.1 SCT CYP2E1 ALDH2 ADH1C ADH1B
10 exocrine pancreatic insufficiency 29.0 SPINK1 SCT PRSS1 CFTR CCK
11 alcoholic liver cirrhosis 28.7 GSTM1 CYP2E1 ALDH2 ADH1C ADH1B
12 acute pancreatitis 28.6 SPINK1 SCT REG3A PRSS1 LPL CPB1
13 pancreatitis 28.5 SPINK1 SCT REG3A PRSS1 LPL CPB1
14 pancreatic cancer 28.0 SPINK1 SCT REG3A PRSS1 NQO1 CFTR
15 diabetes mellitus 27.5 SPINK1 SCT LPL GSTM1 CYP2E1 CCK
16 duodenal obstruction 10.3 SPINK1 PRSS1
17 prss1-related hereditary pancreatitis 10.3 SPINK1 PRSS1 CFTR
18 trimethoprim allergy 10.3 GSTM1 CYP2E1
19 cystic fibrosis 10.1
20 alcoholic hepatitis 10.1
21 pancreas disease 10.1
22 liver disease 10.1
23 oligospermia 10.1 GSTP1 GSTM1 CFTR
24 cardia cancer 10.1 GSTP1 GSTM1 CYP2E1
25 pancreas, annular 10.1 SPINK1 SCT PRSS1
26 alcohol-related birth defect 10.1 CYP2E1 ADH1C ADH1B
27 cholangitis 10.1
28 acetaminophen metabolism 10.0 NQO1 GSTP1 CYP2E1
29 gallbladder disease 1 10.0
30 sister chromatid exchange, frequency of 10.0 GSTM1 CYP2E1 ALDH2
31 fetal alcohol spectrum disorder 10.0 CYP2E1 ALDH2 ADH1B
32 asbestosis 10.0 GSTP1 GSTM1 CAT
33 bronchitis 9.9 GSTM1 CFTR CAT
34 hypertriglyceridemia, familial 9.9
35 cholestasis 9.9
36 liver benign neoplasm 9.9 GSTP1 CYP2E1
37 exfoliation syndrome 9.9 GSTP1 GSTM1 CAT
38 gastroduodenal crohn's disease 9.9 NQO1 CCK
39 intestinal disaccharidase deficiency 9.9 SCT CAT
40 substance abuse 9.9 CYP2E1 ALDH2 ADH1B
41 pulmonary disease, chronic obstructive 9.9 GSTP1 GSTM1 CYP2E1 CFTR
42 obstructive jaundice 9.9
43 cholecystitis 9.9
44 wernicke encephalopathy 9.9
45 pancreatic adenocarcinoma 9.9
46 macular retinal edema 9.9
47 ileus 9.9
48 biliary tract disease 9.9
49 cytokine deficiency 9.9
50 encephalopathy 9.9

Graphical network of the top 20 diseases related to Alcoholic Pancreatitis:



Diseases related to Alcoholic Pancreatitis

Symptoms & Phenotypes for Alcoholic Pancreatitis

MGI Mouse Phenotypes related to Alcoholic Pancreatitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.7 ADH1C ALDH2 CAT CCK CFTR CYP2E1
2 neoplasm MP:0002006 9.1 ALDH2 CAT CYP2E1 GSTP1 NQO1 NQO2

Drugs & Therapeutics for Alcoholic Pancreatitis

Drugs for Alcoholic Pancreatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
2
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
3 Neurotransmitter Agents Phase 4
4 Adrenergic alpha-Agonists Phase 4
5 Adrenergic Agents Phase 4
6 Analgesics Phase 4
7 Hypnotics and Sedatives Phase 4
8 Analgesics, Non-Narcotic Phase 4
9 Adrenergic Agonists Phase 4
10
Pentoxifylline Approved, Investigational Phase 3 6493-05-6 4740
11
Adenosine Approved, Investigational Phase 3 58-61-7 60961
12
Selenium Approved, Investigational, Vet_approved Phase 3 7782-49-2
13
Tocopherol Approved, Investigational Phase 3 1406-66-2, 54-28-4 14986
14
Vitamin E Approved, Nutraceutical, Vet_approved Phase 3 59-02-9 14985
15
Methionine Approved, Nutraceutical Phase 3 63-68-3 6137
16
Vitamin C Approved, Nutraceutical Phase 3 50-81-7 5785 54670067
17
Beta carotene Approved, Nutraceutical Phase 3 7235-40-7
18 Tocotrienol Investigational Phase 3 6829-55-6
19 Phosphodiesterase Inhibitors Phase 3
20 Antioxidants Phase 3
21 Vasodilator Agents Phase 3
22 Platelet Aggregation Inhibitors Phase 3
23 Protective Agents Phase 3
24 Radiation-Protective Agents Phase 3
25 Vitamins Phase 3
26 Carotenoids Phase 3
27 Tocotrienols Phase 3
28 Tocopherols Phase 3
29
Pancrelipase Approved, Investigational 53608-75-6
30
Ethanol Approved 64-17-5 702
31
Ergocalciferol Approved, Nutraceutical 50-14-6 5280793
32
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
33 Pancreatic Polypeptide Investigational 59763-91-6
34 pancreatin
35 Pharmaceutical Solutions
36 Trace Elements
37 Ergocalciferols
38 Hormones
39 Nutrients
40 Micronutrients
41 Calciferol
42 Calcium, Dietary
43 Vitamin D2
44
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Dexmedetomidine vs Placebo in ERCP Sedation.A Randomized Pilot Study Completed NCT01070680 Phase 4 Precedex;sodium chlorid 0,9%
2 Pentoxifylline Treatment in Acute Pancreatitis: A Double-Blind Placebo - Controlled Randomized Trial Completed NCT02487225 Phase 3 Pentoxifylline;Placebo
3 Effect of Antioxidant Supplementation on Pain, Antioxidant Profile and Oxidative Stress in Patients With Chronic Pancreatitis Completed NCT00319358 Phase 3
4 Recurrence of Acute Alcoholic Pancreatitis Completed NCT00523874
5 CT Perfusion of Pancreatic Cancer and Chronic Pancreatitis: Feasibility Study Completed NCT00588367
6 Moderate Versus Aggressive Fluid Therapy in Patient With Mild to Moderate Acute Pancratitis Completed NCT01761539
7 Randomized Clinical Trial of the Effect of Standard Versus Intensive Intervention Protocol in Attempting to Reduce Recurrent Episodes of Acute Alcoholic Pancreatitis Completed NCT00534534
8 Pentoxifylline Treatment in Acute Pancreatitis; A Double-Blind Placebo-Controlled Randomized Trial Completed NCT01292005 Early Phase 1 Pentoxifylline;Placebo
9 The Effect of Vitamin D Substitution on Pancreatic Parenchyma and Development of Fibrosis After First Acute Alcoholic Pancreatitis: A Randomized Prospective Trial Recruiting NCT02965898
10 Assay for the Pancreatic Polypeptide: an Help for Clinical Practice Guidelines in Classification of the Diabetes Recruiting NCT03396146
11 Application of a Wearable Alcohol Sensor for Prevention of Pancreatitis Not yet recruiting NCT04350996
12 Molecular Adsorbent Recirculating System (MARS) in Severe Acute Pancreatitis Suspended NCT00483912

Search NIH Clinical Center for Alcoholic Pancreatitis

Cochrane evidence based reviews: pancreatitis, alcoholic

Genetic Tests for Alcoholic Pancreatitis

Anatomical Context for Alcoholic Pancreatitis

MalaCards organs/tissues related to Alcoholic Pancreatitis:

40
Pancreas, Liver, Testes, Heart, Colon, Bone, Spleen

Publications for Alcoholic Pancreatitis

Articles related to Alcoholic Pancreatitis:

(show top 50) (show all 928)
# Title Authors PMID Year
1
Association analyses of genetic polymorphisms of GSTM1, GSTT1, NQO1, NAT2, LPL, PRSS1, PSTI, and CFTR with chronic alcoholic pancreatitis in Japan. 61 54
18986377 2010
2
Morphological and functional evaluation of the pancreatic duct with secretin-stimulated magnetic resonance cholangiopancreatography in alcoholic pancreatitis patients. 54 61
18470615 2008
3
Individual susceptibility to alcoholic pancreatitis. 61 54
18336667 2008
4
A novel SPINK1 gene mutation, c.206C>T, in a Thai patient with chronic alcoholic pancreatitis. 54 61
18182741 2008
5
Alcohol/cholecystokinin-evoked pancreatic acinar basolateral exocytosis is mediated by protein kinase C alpha phosphorylation of Munc18c. 61 54
17324928 2007
6
[Impairment of humoral regulation of exocrine pancreatic function in chronic pancreatitis]. 54 61
17460968 2007
7
[Genetic polymorphisms of alcohol-metabolizing enzymes and cytokines in patients with alcohol induced pancreatitis and alcoholic liver cirrhosis]. 61 54
15220553 2004
8
Mechanisms of alcoholic pancreatitis. Proceedings of a conference. Chicago, Illinois, USA, November 2002. 61 54
14576487 2003
9
Mutations of the CFTR gene in pancreatic disease. 54 61
14576497 2003
10
Role of alcohol metabolism in alcoholic pancreatitis. 61 54
14576493 2003
11
Animal and in vitro models of alcoholic pancreatitis: role of cholecystokinin. 54 61
14576490 2003
12
Limited contribution of the SPINK1 N34S mutation to the risk and severity of alcoholic chronic pancreatitis: a report from the United States. 61 54
12822871 2003
13
Study of polymorphisms in the CYP2E1 gene in patients with alcoholic pancreatitis. 61 54
11331106 2001
14
Alcohol and aldehyde dehydrogenase polymorphisms in Japanese patients with alcohol-induced chronic pancreatitis. 61 54
11117576 2000
15
Cholecystokinin in acute alcoholic and biliary pancreatitis. 61 54
11185710 2000
16
Genotypes of alcohol-metabolizing enzymes in relation to alcoholic chronic pancreatitis in Japan. 54 61
10235286 1999
17
Alcoholic pancreatitis and polymorphisms of the variable length polythymidine tract in the cystic fibrosis gene. 54 61
10195826 1999
18
Alcoholism and alcoholic organ damage and genetic polymorphisms of alcohol metabolizing enzymes in Chinese patients. 61 54
8985275 1997
19
Genotypes of alcohol-metabolizing enzymes and the risk for alcoholic chronic pancreatitis in Japanese alcoholics. 61 54
8986224 1996
20
Serum pancreas-specific protein in acute pancreatitis. Its clinical utility in comparison with serum amylase. 54 61
7510410 1994
21
Characteristics and outcome of patients presenting with acute Pancreatitis: A one-year descriptive study from a tertiary care center in Lebanon. 61
32409259 2020
22
Splenic rupture caused by pancreatic pseudocyst successfully treated by endoscopic ultrasound-guided drainage. 61
32514684 2020
23
Fibrocalculous pancreatic diabetes. 61
32553576 2020
24
Increase in the incidence of alcoholic pancreatitis and alcoholic liver disease in Iceland: impact of per capita alcohol consumption. 61
32289240 2020
25
Susceptibility Factors and Cellular Mechanisms Underlying Alcoholic Pancreatitis. 61
32056245 2020
26
Ethanol feeding accelerates pancreatitis progression in CPA1 N256K mutant mice. 61
32116022 2020
27
Association between genetic variants in CYP2E1 and CTRC genes and susceptibility to alcoholic pancreatitis: A systematic review and meta-analysis. 61
32045777 2020
28
Hemorrhagic pancreatic pseudocyst: A rare complication. 61
32197717 2020
29
Classification, Severity Assessment, and Prevention of Recurrences in Acute Pancreatitis. 61
32192420 2020
30
Critical Role of TFEB-Mediated Lysosomal Biogenesis in Alcohol-Induced Pancreatitis in Mice and Humans. 61
31987928 2020
31
Lifetime Drinking History of Persons With Chronic Pancreatitis. 61
31603464 2019
32
Blind After a Binge: Purtscher-like Retinopathy in Acute Alcoholic Pancreatitis. 61
32309468 2019
33
Gut Microbiota in Alcoholic Hepatitis is Disparate from Those in Acute Alcoholic Pancreatitis and Biliary Disease. 61
31889749 2019
34
Screening of Sera from Patients with Pancreatitis by an Apoptosis Assay of Skin-derived Cells. 61
31650798 2019
35
Acute Pancreatitis: An Exploratory, Cross-sectional, Single-center Study of the Epidemiological Features of the Disease in a Sample of Saudi Patients. 61
31529932 2019
36
Patterns of alcohol consumption and nutrition intake in patients with alcoholic liver disease and alcoholic pancreatitis in North Indian men. 61
31406925 2019
37
Comparative study of the outcome between alcohol and gallstone pancreatitis in a high-volume tertiary care center. 61
31406928 2019
38
[Protective Effect of a Dihydroflavonol Glycoside from Coreopsis tinctoria Nutt. in Mouse Model of Alcoholic Acute Pancreatitis]. 61
31642231 2019
39
Splenic artery pseudoaneurysm presenting with massive rectal bleeding. 61
31011381 2019
40
Does Etiology of Pancreatitis Matter? Differences in Outcomes Among Patients With Post-Endoscopic Retrograde Cholangiopancreatography, Acute Biliary, and Alcoholic Pancreatitis. 61
30946237 2019
41
Black pleural effusion caused by pancreatic pseudocyst rupture. 61
30847213 2019
42
DIFFERENT SCORING SYSTEMS IN ACUTE ALCOHOLIC PANCREATITIS: WHICH ONE TO FOLLOW? AN ONGOING DILEMA. 61
31633726 2019
43
Structural, functional and molecular dynamics analysis of cathepsin B gene SNPs associated with tropical calcific pancreatitis, a rare disease of tropics. 61
31592339 2019
44
Predicting the efficacy of surgery for pain relief in patients with alcoholic chronic pancreatitis. 61
30029988 2018
45
Extracorporeal shock wave lithotripsy for pancreatic duct stones: an observational study. 61
30353766 2018
46
Identification of risk factors for pancreatic pseudocysts formation, intervention and recurrence: a 15-year retrospective analysis in a tertiary hospital in China. 61
30285639 2018
47
Myths and realities about alcohol and smoking in chronic pancreatitis. 61
29965868 2018
48
[Clinical study of no necrotic cavity lavage after debridement and drainage in patients with infected pancreatic necrosis]. 61
30032532 2018
49
Prevalence of inflammatory bowel disease in alcoholic, non-alcoholic and autoimmune pancreatitis. 61
29734447 2018
50
Analysis of influencing factors of severity in acute pancreatitis using big data mining. 61
30304146 2018

Variations for Alcoholic Pancreatitis

Expression for Alcoholic Pancreatitis

Search GEO for disease gene expression data for Alcoholic Pancreatitis.

Pathways for Alcoholic Pancreatitis

Pathways related to Alcoholic Pancreatitis according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.9 PRSS1 NQO2 NQO1 LPL GSTP1 GSTM1
2
Show member pathways
13.02 NQO2 GSTP1 GSTM1 CYP2E1 ALDH2 ADH1C
3
Show member pathways
12.64 GSTP1 GSTM1 CYP2E1 ALDH2 ADH1C ADH1B
4 11.91 NQO1 GSTP1 GSTM1
5 11.89 NQO1 GSTP1 GSTM1
6
Show member pathways
11.68 CYP2E1 CAT ALDH2
7 11.56 SCT PRSS1 CPB1 CFTR CCK
8
Show member pathways
11.52 NQO1 GSTP1 GSTM1 CYP2E1
9 11.1 NQO1 GSTP1 GSTM1
10 10.96 GSTP1 GSTM1 CYP2E1
11 10.91 NQO2 NQO1 GSTP1
12
Show member pathways
10.76 ALDH2 ADH1B
13
Show member pathways
10.75 GSTP1 ALDH2 ADH1C ADH1B
14 10.66 ADH1C ADH1B
15
Show member pathways
10.57 CYP2E1 ADH1B
16 10.34 SCT CCK
17 10.21 NQO1 GSTM1 CYP2E1
18
Show member pathways
10.1 CYP2E1 CAT ALDH2 ADH1B

GO Terms for Alcoholic Pancreatitis

Cellular components related to Alcoholic Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 SPINK1 SCT REG3A PRSS1 LPL GSTP1
2 extracellular space GO:0005615 9.28 SPINK1 SCT REG3A PRSS1 LPL GSTP1

Biological processes related to Alcoholic Pancreatitis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 response to estradiol GO:0032355 9.65 NQO1 GSTP1 CAT
2 response to toxic substance GO:0009636 9.63 NQO1 GSTP1 CAT
3 response to ethanol GO:0045471 9.56 NQO1 GSTP1 CYP2E1 CAT
4 prostaglandin metabolic process GO:0006693 9.55 GSTP1 GSTM1
5 retinoic acid metabolic process GO:0042573 9.54 ADH1C ADH1B
6 sperm capacitation GO:0048240 9.52 SPINK1 CFTR
7 glutathione derivative biosynthetic process GO:1901687 9.51 GSTP1 GSTM1
8 triglyceride metabolic process GO:0006641 9.5 LPL CYP2E1 CAT
9 oxidation-reduction process GO:0055114 9.5 NQO2 NQO1 CYP2E1 CAT ALDH2 ADH1C
10 response to reactive oxygen species GO:0000302 9.49 GSTP1 CAT
11 xenobiotic metabolic process GO:0006805 9.46 NQO2 NQO1 GSTP1 CYP2E1
12 hepoxilin biosynthetic process GO:0051122 9.43 GSTP1 GSTM1
13 response to L-ascorbic acid GO:0033591 9.4 GSTP1 CAT
14 response to ozone GO:0010193 9.37 CYP2E1 CAT
15 ethanol oxidation GO:0006069 8.8 ALDH2 ADH1C ADH1B

Molecular functions related to Alcoholic Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.67 GSTM1 CYP2E1 CFTR CAT
2 glutathione transferase activity GO:0004364 9.4 GSTP1 GSTM1
3 retinol dehydrogenase activity GO:0004745 9.32 ADH1C ADH1B
4 glutathione binding GO:0043295 9.26 GSTP1 GSTM1
5 oxidoreductase activity GO:0016491 9.17 NQO2 NQO1 CYP2E1 CAT ALDH2 ADH1C
6 alcohol dehydrogenase activity, zinc-dependent GO:0004024 9.16 ADH1C ADH1B
7 NAD(P)H dehydrogenase (quinone) activity GO:0003955 8.96 NQO2 NQO1

Sources for Alcoholic Pancreatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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