MCID: ALD013
MIFTS: 38

Aldosterone-Producing Adenoma

Aliases & Classifications for Aldosterone-Producing Adenoma

MalaCards integrated aliases for Aldosterone-Producing Adenoma:

Name: Aldosterone-Producing Adenoma 25
Conn Adenoma 25 73
Primary Aldosteronism Due to Conn Adenoma 25
Aldosterone-Secreting Adenoma 25
Aldosteronoma 25

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UMLS 73 C0009777

Summaries for Aldosterone-Producing Adenoma

Genetics Home Reference : 25 An aldosterone-producing adenoma is a noncancerous (benign) tumor that develops in an adrenal gland, which is a small hormone-producing gland located on top of each kidney. In most cases, individuals develop a single tumor in one of the adrenal glands. The adrenal tumor produces too much of the hormone aldosterone, which is a condition known as primary hyperaldosteronism. Aldosterone helps regulate the body's fluid levels and blood pressure by controlling the amount of salt retained by the kidneys. Excess aldosterone causes the kidneys to retain more salt than normal, which increases the body's fluid levels and blood pressure. People with an aldosterone-producing adenoma may develop severe high blood pressure (hypertension), and they have an increased risk of heart attack, stroke, or an irregular heart beat (atrial fibrillation).

MalaCards based summary : Aldosterone-Producing Adenoma, also known as conn adenoma, is related to adenoma and hyperaldosteronism, familial, type i. An important gene associated with Aldosterone-Producing Adenoma is KCNJ5 (Potassium Voltage-Gated Channel Subfamily J Member 5), and among its related pathways/superpathways are Vascular smooth muscle contraction and Aldosterone synthesis and secretion. The drugs Epinephrine and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include heart, adrenal gland and kidney, and related phenotype is cardiovascular system.

Wikipedia : 76 Primary aldosteronism, also known as primary hyperaldosteronism or Conn\'s syndrome, refers to the... more...

Related Diseases for Aldosterone-Producing Adenoma

Diseases related to Aldosterone-Producing Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
# Related Disease Score Top Affiliating Genes
1 adenoma 30.2 CYP11B2 CYP21A2 KCNJ5
2 hyperaldosteronism, familial, type i 29.6 CYP11B2 REN
3 adrenal adenoma 27.9 CYP11B2 CYP21A2 KCNJ5 REN
4 conn's syndrome 27.9 CYP11B2 CYP21A2 KCNJ5 REN
5 primary aldosteronism, seizures, and neurologic abnormalities 11.3
6 hyperaldosteronism, familial, type ii 11.2
7 hypertension, essential 10.1
8 familial hyperaldosteronism 10.1 CYP11B2 KCNJ5
9 hypokalemia 10.0
10 hypoaldosteronism 10.0 CYP11B2 REN
11 pheochromocytoma 9.9
12 acth-independent macronodular adrenal hyperplasia 9.9
13 familial adenomatous polyposis 9.9
14 malignant hypertension 9.9
15 teratocarcinoma 9.9
16 type i 9.9
17 multiple endocrine neoplasia 9.9
18 adrenal cortex disease 9.7 CYP11B2 KCNJ5 REN
19 liddle syndrome 9.7 CYP11B2 REN
20 adrenal gland disease 9.6 CYP11B2 KCNJ5 REN
21 acute adrenal insufficiency 9.6 CYP21A2 REN
22 cell type benign neoplasm 9.6 CYP11B2 KCNJ5 REN
23 steroid inherited metabolic disorder 9.6 CYP11B2 CYP21A2
24 adrenal cortical hypofunction 9.5 CYP21A2 REN
25 adrenal rest tumor 9.4 CYP11B2 CYP21A2
26 pseudohyperkalemia, familial, 2, due to red cell leak 9.1 CYP11B2 CYP21A2 REN
27 adrenal carcinoma 9.1 CYP11B2 CYP21A2 REN
28 lipoid congenital adrenal hyperplasia 9.1 CYP11B2 CYP21A2 REN
29 organ system benign neoplasm 9.1 ATP1A1 CYP11B2 KCNJ5 REN
30 adrenocortical carcinoma, hereditary 9.1 CYP11B2 CYP21A2
31 endocrine organ benign neoplasm 8.3 ATP1A1 CACNA1D CYP11B2 KCNJ5 REN

Graphical network of the top 20 diseases related to Aldosterone-Producing Adenoma:



Diseases related to Aldosterone-Producing Adenoma

Symptoms & Phenotypes for Aldosterone-Producing Adenoma

MGI Mouse Phenotypes related to Aldosterone-Producing Adenoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.02 ATP1A1 CACNA1D CYP11B2 KCNJ5 REN

Drugs & Therapeutics for Aldosterone-Producing Adenoma

Drugs for Aldosterone-Producing Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 3,Not Applicable 51-43-4 5816
2
Racepinephrine Approved Phase 3,Not Applicable 329-65-7 838
3
Hydrocortisone Approved, Vet_approved Phase 3,Not Applicable 50-23-7 5754
4 Kava Approved, Investigational, Nutraceutical Phase 3 9000-38-8
5 Mineralocorticoid Receptor Antagonists Phase 3,Not Applicable
6 Mineralocorticoids Phase 3,Not Applicable
7 Neurotransmitter Agents Phase 3,Not Applicable
8 Hormones Phase 3,Not Applicable
9 Peripheral Nervous System Agents Phase 3,Not Applicable
10 Epinephryl borate Phase 3,Not Applicable
11 Autonomic Agents Phase 3,Not Applicable
12 beta-endorphin Phase 3
13 Respiratory System Agents Phase 3,Not Applicable
14 Adrenergic Agents Phase 3,Not Applicable
15 Adrenergic Agonists Phase 3,Not Applicable
16 Adrenergic alpha-Agonists Phase 3,Not Applicable
17 Adrenergic beta-Agonists Phase 3,Not Applicable
18 Adrenocorticotropic Hormone Phase 3
19 Mydriatics Phase 3,Not Applicable
20 Cortisol succinate Phase 3,Not Applicable
21 Vasoconstrictor Agents Phase 3,Not Applicable
22 Anti-Asthmatic Agents Phase 3,Not Applicable
23 Hydrocortisone 17-butyrate 21-propionate Phase 3,Not Applicable
24 Hydrocortisone acetate Phase 3,Not Applicable
25 Melanocyte-Stimulating Hormones Phase 3
26 Bronchodilator Agents Phase 3,Not Applicable
27
Spironolactone Approved ,Not Applicable 1952-01-7, 52-01-7 5833
28
Dopamine Approved 51-61-6, 62-31-7 681
29
Amiloride Approved 2016-88-8, 2609-46-3 16231
30
Eplerenone Approved Not Applicable 107724-20-9 150310 443872
31
Etomidate Approved Not Applicable 33125-97-2 36339 667484
32
Clarithromycin Approved Not Applicable 81103-11-9 84029
33
Butyric Acid Experimental, Investigational Not Applicable 107-92-6 264
34 diuretics ,Not Applicable
35 Natriuretic Agents ,Not Applicable
36 Hormone Antagonists ,Not Applicable
37 Diuretics, Potassium Sparing ,Not Applicable
38 Dopamine Agents
39 Hormones, Hormone Substitutes, and Hormone Antagonists ,Not Applicable
40 Protective Agents
41 Hydrocortisone-17-butyrate Not Applicable
42 Antihypertensive Agents Not Applicable
43 Anti-Inflammatory Agents Not Applicable
44 Sodium Channel Blockers
45 Epithelial Sodium Channel Blockers
46 Central Nervous System Depressants Not Applicable
47 Anesthetics Not Applicable
48 Anesthetics, General Not Applicable
49 Anesthetics, Intravenous Not Applicable
50 Hypnotics and Sedatives Not Applicable

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 SPARTACUS: Subtyping Primary Aldosteronism: a Randomized Trial Comparing Adrenal Vein Sampling and Computed Tomography Scan. Completed NCT01096654 Phase 3
2 D2 Dopamine Receptor on Human Aldosterone-Producing Adenoma and Its Role in Aldosterone Secretion and Cell Proliferation Unknown status NCT00173446
3 Postoperative Cardiovascular Index Change of Primary Aldosteronism Unknown status NCT00746070
4 Prevalence of Primary Aldosteronism in Hypertensive Patients Presenting With Atrial Flutter or Fibrillation Unknown status NCT01267747
5 Arterial Stiffness Index as a Predictor of Surgically Correctable Primary Aldosteronism Completed NCT01190501 Not Applicable
6 Intraoperative Analysis of Cortisol During Adrenal Vein Sampling Completed NCT01761344 Not Applicable
7 Primary Aldosteronism in General Practice: Organ Damage, Epidemiology and Treatment Completed NCT01728493
8 Adrenal Vein Sampling International Study (AVIS Study) Completed NCT01234220
9 Radiofrequency Endoscopic Ablation With Ultrasound Guidance: a Non-surgical Treatment for Aldosterone-producing Adenomas Recruiting NCT03405025 Not Applicable
10 Glucose Metabolism in Subjects With Aldosterone-Producing Adenomas Recruiting NCT02362308 Not Applicable mineralocorticoid receptor antagonist
11 Renal Sympathetic Denervation From The Adventitia on Hypertension Recruiting NCT02642445 Not Applicable
12 Prospective Study Assessing Blood Pressure and Other Outcomes Post-treatment in Patients With Primary Aldosteronism Recruiting NCT03174847 Mineralocorticoid Receptor Antagonists
13 IS Metomidate PET-CT Superior to Adrenal Venous Sampling in Predicting Outcome From Adrenalectomy in Patients With Primary Hyperaldosteronism Recruiting NCT02945904
14 Laparoscopic Adrenalectomy Versus Radiofrequency Ablation Active, not recruiting NCT02030587 Not Applicable
15 11C-Metomidate PET Versus Adrenal Vein Sampling in Primary Aldosteronism Active, not recruiting NCT01567111 Not Applicable
16 Macrolides for KCNJ5 - Mutated Aldosterone-Producing Adenoma (MAPA) Not yet recruiting NCT03414918 Not Applicable Clarithromycin
17 Rapid Cortisol Assay in Adrenal Vein Sampling Not yet recruiting NCT03449797 Not Applicable

Search NIH Clinical Center for Aldosterone-Producing Adenoma

Genetic Tests for Aldosterone-Producing Adenoma

Anatomical Context for Aldosterone-Producing Adenoma

MalaCards organs/tissues related to Aldosterone-Producing Adenoma:

41
Heart, Adrenal Gland, Kidney, Testes, Cortex, Adrenal Cortex, Pituitary

Publications for Aldosterone-Producing Adenoma

Articles related to Aldosterone-Producing Adenoma:

(show top 50) (show all 137)
# Title Authors Year
1
KCNJ5 mutation as a predictor for resolution of hypertension after surgical treatment of aldosterone-producing adenoma. ( 29016532 )
2018
2
Targeting CXCR4 (CXC Chemokine Receptor Type 4) for Molecular Imaging of Aldosterone-Producing Adenoma. ( 29279316 )
2018
3
Calneuron 1 Increased Ca2+ in the Endoplasmic Reticulum and Aldosterone Production in Aldosterone-Producing Adenoma. ( 29109191 )
2018
4
Inflammation and Fibrosis in Perirenal Adipose Tissue of Patients With Aldosterone-Producing Adenoma. ( 29059354 )
2018
5
Macrolides for KCNJ5-mutated aldosterone-producing adenoma (MAPA): design of a study for personalized diagnosis of primary aldosteronism. ( 29409357 )
2018
6
The Angiotensin Type 2 Receptor In A Human Adrenocortical Zona Glomerulosa And In Aldosterone-Producing Adenoma: Low Expression And No Functional Role. ( 29436482 )
2018
7
Mineralocorticoid receptor antagonism protects the aorta from vascular smooth muscle cell proliferation and collagen deposition in a rat model of adrenal aldosterone-producing adenoma. ( 29164516 )
2018
8
A pedunculated aldosterone-producing adenoma drained by an extra vein causing puzzling results of adrenal vein sampling. ( 29741297 )
2018
9
GSTA1 expression is correlated with aldosterone level in KCNJ5-mutated adrenal aldosterone-producing adenoma. ( 29165597 )
2017
10
Aberrant G protein-receptor expression is associated with DNA methylation in aldosterone-producing adenoma. ( 28870781 )
2017
11
Characteristics of Japanese aldosterone-producing adenomas with KCNJ5 mutations. ( 27681703 )
2017
12
Aldosterone-Producing Adenomas: Histopathology-Genotype Correlation and Identification of a Novel CACNA1D Mutation. ( 28584016 )
2017
13
Macrolides selectively inhibit mutant KCNJ5 potassium channels that cause aldosterone-producing adenoma. ( 28604387 )
2017
14
Evaluation of Cortisol Production in Aldosterone-Producing Adenoma. ( 29069700 )
2017
15
Molecular characteristics of the KCNJ5 mutated aldosterone-producing adenomas. ( 28747387 )
2017
16
Favorable surgical outcomes of aldosterone-producing adenoma based on lateralization by CT imaging and hypokalemia: a non-AVS-based strategy. ( 28918446 )
2017
17
Expression and Histopathological Significance of Disabled-2 in Aldosterone-Producing Adenoma. ( 28514805 )
2017
18
Quantitative Value of Aldosterone-Renin Ratio for Detection of Aldosterone-Producing Adenoma: The Aldosterone-Renin Ratio for Primary Aldosteronism (AQUARR) Study. ( 28529209 )
2017
19
Review of Markers of Zona Glomerulosa and Aldosterone-Producing Adenoma Cells. ( 28947616 )
2017
20
Purkinje cell protein 4 expression is associated with DNA methylation status in aldosterone-producing adenoma. ( 29294065 )
2017
21
A Novel Case of Somatic<i>KCNJ5</i>Mutation in Pediatric-Onset Aldosterone-Producing Adenoma. ( 29264557 )
2017
22
CTNNB1 Mutation in Aldosterone Producing Adenoma. ( 28956362 )
2017
23
Arterial stiffness and blood pressure improvement in aldosterone-producing adenoma harboring KCNJ5 mutations after adrenalectomy. ( 28415786 )
2017
24
Molecular Heterogeneity in Aldosterone-Producing Adenomas. ( 26765578 )
2016
25
Radiofrequency ablation compared with laparoscopic adrenalectomy for aldosterone-producing adenoma. ( 27511444 )
2016
26
Comparison of radiofrequency ablation versus laparoscopic adrenalectomy for benign aldosterone-producing adenoma. ( 27300650 )
2016
27
Expression of inflammation-related genes in aldosterone-producing adenomas with KCNJ5 mutation. ( 27282482 )
2016
28
Is Laparoendoscopic Single-Site Adrenalectomy a Feasible Alternative in Treating Aldosterone-Producing Adenoma? ( 27975056 )
2016
29
Aldosterone producing adenoma with a somatic KCNJ5 mutation revealing APC dependent Familial Adenomatous Polyposis. ( 27648962 )
2016
30
Clinical and Steroidogenic Characteristics of Aldosterone-Producing Adenomas With ATPase or CACNA1D Gene Mutations. ( 26606680 )
2016
31
PRKACA Somatic Mutations Are Rare Findings in Aldosterone-Producing Adenomas. ( 27270477 )
2016
32
Genetics of Aldosterone-Producing Adenoma in Korean Patients. ( 26807823 )
2016
33
Time course and factors predicting arterial stiffness reversal in patients with aldosterone-producing adenoma after adrenalectomy: prospective study of 102 patients. ( 26883298 )
2016
34
Gonadotropin-Releasing Hormone Stimulate Aldosterone Production in a Subset of Aldosterone-Producing Adenoma. ( 27196470 )
2016
35
Role of Nox2 and p22phox in Persistent Postoperative Hypertension in Aldosterone-Producing Adenoma Patients after Adrenalectomy. ( 27057164 )
2016
36
Clinical Outcomes following Percutaneous Radiofrequency Ablation of Unilateral Aldosterone-Producing Adenoma: Comparison with Adrenalectomy. ( 27241391 )
2016
37
Aldosterone-producing Adenoma in Primary Aldosteronism: CT-guided Radiofrequency Ablation-Long-term Results and Recurrence Rate. ( 27232638 )
2016
38
Hypomethylation of CYP11B2 in Aldosterone-Producing Adenoma. ( 27754862 )
2016
39
GNAS mutations in adrenal aldosterone-producing adenomas. ( 26743443 )
2016
40
SY 03-3 OVERVIEW OF SOMATIC MUTATIONS AND EPIGENETIC REGULATION OF ALDOSTERONE PRODUCING ADENOMA (APA). ( 27642883 )
2016
41
Intratumoral heterogeneity of steroidogenesis in aldosterone-producing adenoma revealed by intensive double- and triple-immunostaining for CYP11B2/B1 and CYP17. ( 26597777 )
2016
42
PTH Is a Promising Auxiliary Index for the Clinical Diagnosis of Aldosterone-Producing Adenoma. ( 26304960 )
2016
43
Activating mutations in CTNNB1 in aldosterone producing adenomas. ( 26815163 )
2016
44
Prevalence and characterization of somatic mutations in chinese aldosterone-producing adenoma patients. ( 25906099 )
2015
45
A Meta-Analysis of Somatic KCNJ5 K(+) Channel Mutations In 1636 Patients With an Aldosterone-Producing Adenoma. ( 26066531 )
2015
46
3I^-Hydroxysteroid dehydrogenase isoforms in human aldosterone-producing adenoma. ( 25458695 )
2015
47
Integration of transcriptome and methylome analysis of aldosterone-producing adenomas. ( 25953827 )
2015
48
Novel somatic mutations and distinct molecular signature in aldosterone-producing adenomas. ( 26285814 )
2015
49
Immunohistochemical, genetic and clinical characterization of sporadic aldosterone-producing adenomas. ( 25958045 )
2015
50
Comparison of cardiovascular complications in patients with and without KCNJ5 gene mutations harboring aldosterone-producing adenomas. ( 25253161 )
2015

Variations for Aldosterone-Producing Adenoma

Expression for Aldosterone-Producing Adenoma

Search GEO for disease gene expression data for Aldosterone-Producing Adenoma.

Pathways for Aldosterone-Producing Adenoma

Pathways related to Aldosterone-Producing Adenoma according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.22 ATP1A1 CACNA1D KCNJ5
2
Show member pathways
11.88 ATP1A1 CACNA1D CYP11B2 CYP21A2 KCNJ5
3
Show member pathways
11.6 ATP1A1 CACNA1D
4 11.55 CACNA1D KCNJ5
5
Show member pathways
11.42 CYP11B2 CYP21A2
6
Show member pathways
11.36 CYP11B2 REN
7 11.32 ATP1A1 CACNA1D
8 11.18 CACNA1D REN
9
Show member pathways
11.13 CYP11B2 CYP21A2
10 10.9 ATP1A1 CACNA1D
11 10.88 ATP1A1 CACNA1D KCNJ5
12
Show member pathways
10.48 CYP11B2 CYP21A2

GO Terms for Aldosterone-Producing Adenoma

Cellular components related to Aldosterone-Producing Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 T-tubule GO:0030315 8.62 ATP1A1 KCNJ5

Biological processes related to Aldosterone-Producing Adenoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.67 ATP1A1 CACNA1D KCNJ5
2 potassium ion transport GO:0006813 9.51 ATP1A1 KCNJ5
3 steroid metabolic process GO:0008202 9.48 CYP11B2 CYP21A2
4 regulation of blood pressure GO:0008217 9.46 ATP1A1 REN
5 steroid biosynthetic process GO:0006694 9.43 CYP11B2 CYP21A2
6 potassium ion import GO:0010107 9.4 ATP1A1 KCNJ5
7 regulation of heart rate by cardiac conduction GO:0086091 9.37 CACNA1D KCNJ5
8 sterol metabolic process GO:0016125 9.32 CYP11B2 CYP21A2
9 cardiac muscle cell action potential involved in contraction GO:0086002 9.26 ATP1A1 CACNA1D
10 glucocorticoid biosynthetic process GO:0006704 9.16 CYP11B2 CYP21A2
11 potassium ion import across plasma membrane GO:1990573 8.96 ATP1A1 KCNJ5
12 mineralocorticoid biosynthetic process GO:0006705 8.62 CYP11B2 CYP21A2

Molecular functions related to Aldosterone-Producing Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.32 CYP11B2 CYP21A2
2 voltage-gated ion channel activity GO:0005244 9.26 CACNA1D KCNJ5
3 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.16 CYP11B2 CYP21A2
4 steroid hydroxylase activity GO:0008395 8.96 CYP11B2 CYP21A2
5 ankyrin binding GO:0030506 8.62 ATP1A1 CACNA1D

Sources for Aldosterone-Producing Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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