MCID: ALD013
MIFTS: 41

Aldosterone-Producing Adenoma

Categories: Blood diseases, Endocrine diseases

Aliases & Classifications for Aldosterone-Producing Adenoma

MalaCards integrated aliases for Aldosterone-Producing Adenoma:

Name: Aldosterone-Producing Adenoma 26 17
Conn Adenoma 26 74
Primary Aldosteronism Due to Conn Adenoma 26
Aldosterone-Secreting Adenoma 26
Aldosteronoma 26

Classifications:



External Ids:

UMLS 74 C0009777

Summaries for Aldosterone-Producing Adenoma

Genetics Home Reference : 26 An aldosterone-producing adenoma is a noncancerous (benign) tumor that develops in an adrenal gland, which is a small hormone-producing gland located on top of each kidney. In most cases, individuals develop a single tumor in one of the adrenal glands. The adrenal tumor produces too much of the hormone aldosterone, which is a condition known as primary hyperaldosteronism. Aldosterone helps regulate the body's fluid levels and blood pressure by controlling the amount of salt retained by the kidneys. Excess aldosterone causes the kidneys to retain more salt than normal, which increases the body's fluid levels and blood pressure. People with an aldosterone-producing adenoma may develop severe high blood pressure (hypertension), and they have an increased risk of heart attack, stroke, or an irregular heart beat (atrial fibrillation).

MalaCards based summary : Aldosterone-Producing Adenoma, also known as conn adenoma, is related to adenoma and adrenal adenoma. An important gene associated with Aldosterone-Producing Adenoma is KCNJ5 (Potassium Voltage-Gated Channel Subfamily J Member 5), and among its related pathways/superpathways are Cardiac conduction and Vascular smooth muscle contraction. The drugs Racepinephrine and Epinephrine have been mentioned in the context of this disorder. Affiliated tissues include heart, adrenal gland and kidney.

Wikipedia : 77 Primary aldosteronism, also known as primary hyperaldosteronism or Conn''s syndrome, refers to the... more...

Related Diseases for Aldosterone-Producing Adenoma

Diseases related to Aldosterone-Producing Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
# Related Disease Score Top Affiliating Genes
1 adenoma 31.5 CYP11B2 CYP21A2 KCNJ5
2 adrenal adenoma 29.8 CYP11B2 CYP21A2 KCNJ5
3 conn's syndrome 29.7 CYP11B2 CYP21A2 KCNJ5
4 hyperaldosteronism, familial, type ii 11.4
5 hypertension, essential 10.3
6 pheochromocytoma 10.3
7 adrenal gland pheochromocytoma 10.2
8 hypokalemia 10.2
9 adrenal cortical adenoma 10.1
10 familial hyperaldosteronism 10.1 CYP11B2 KCNJ5
11 adrenal cortex disease 10.1 CYP11B2 KCNJ5
12 endocrine organ benign neoplasm 10.0 CYP11B2 KCNJ5
13 hyperaldosteronism, familial, type i 10.0
14 neurofibromatosis, type i 10.0
15 neurofibromatosis, type iv, of riccardi 10.0
16 retinoblastoma 10.0
17 acth-independent macronodular adrenal hyperplasia 10.0
18 pituitary adenoma, prolactin-secreting 10.0
19 hyperaldosteronism, familial, type iii 10.0
20 primary aldosteronism, seizures, and neurologic abnormalities 10.0
21 glomerulonephritis 10.0
22 familial adenomatous polyposis 10.0
23 malignant hypertension 10.0
24 hyperparathyroidism 10.0
25 renovascular hypertension 10.0
26 teratocarcinoma 10.0
27 myopathy 10.0
28 proliferative glomerulonephritis 10.0
29 mesangial proliferative glomerulonephritis 10.0
30 parathyroid adenoma 10.0
31 multiple endocrine neoplasia 10.0
32 steroid inherited metabolic disorder 10.0 CYP11B2 CYP21A2
33 pseudohyperkalemia, familial, 2, due to red cell leak 10.0 CYP11B2 CYP21A2
34 cell type benign neoplasm 10.0 CYP11B2 KCNJ5
35 adrenal rest tumor 10.0 CYP11B2 CYP21A2
36 cortisone reductase deficiency 10.0 CYP21A2 KCNJ5
37 oncocytoma 10.0
38 meningioma, familial 10.0
39 spinal meningioma 10.0
40 liposarcoma 10.0
41 secretory meningioma 10.0
42 horseshoe kidney 10.0
43 retroperitoneal liposarcoma 10.0
44 adrenal carcinoma 9.9 CYP11B2 CYP21A2
45 lipoid congenital adrenal hyperplasia 9.8 CYP11B2 CYP21A2
46 adrenocortical carcinoma, hereditary 9.7 CYP11B2 CYP21A2
47 adrenal gland disease 9.5 ATP1A1 CACNA1D CYP11B2 KCNJ5

Graphical network of the top 20 diseases related to Aldosterone-Producing Adenoma:



Diseases related to Aldosterone-Producing Adenoma

Symptoms & Phenotypes for Aldosterone-Producing Adenoma

Drugs & Therapeutics for Aldosterone-Producing Adenoma

Drugs for Aldosterone-Producing Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 56)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Racepinephrine Approved Phase 3,Not Applicable 329-65-7 838
2
Epinephrine Approved, Vet_approved Phase 3,Not Applicable 51-43-4 5816
3
Hydrocortisone Approved, Vet_approved Phase 3,Not Applicable 50-23-7 5754
4
Hydrocortisone acetate Approved, Vet_approved Phase 3,Not Applicable 50-03-3
5 Kava Approved, Investigational, Nutraceutical Phase 3 9000-38-8
6 Epinephryl borate Phase 3,Not Applicable
7 Sympathomimetics Phase 3,Not Applicable
8 Peripheral Nervous System Agents Phase 3,Not Applicable
9 Neurotransmitter Agents Phase 3,Not Applicable
10 Hormones Phase 3,Not Applicable
11 Mineralocorticoid Receptor Antagonists Phase 3,Not Applicable
12 Autonomic Agents Phase 3,Not Applicable
13 Mineralocorticoids Phase 3,Not Applicable
14 Adrenergic Agents Phase 3,Not Applicable
15 Anti-Asthmatic Agents Phase 3,Not Applicable
16 Respiratory System Agents Phase 3,Not Applicable
17 Adrenocorticotropic Hormone Phase 3
18 Vasoconstrictor Agents Phase 3,Not Applicable
19 Adrenergic Agonists Phase 3,Not Applicable
20 Hydrocortisone hemisuccinate Phase 3,Not Applicable
21 Bronchodilator Agents Phase 3,Not Applicable
22 Adrenergic beta-Agonists Phase 3,Not Applicable
23 beta-endorphin Phase 3
24 Mydriatics Phase 3,Not Applicable
25 Melanocyte-Stimulating Hormones Phase 3
26 Hydrocortisone 17-butyrate 21-propionate Phase 3,Not Applicable
27 Adrenergic alpha-Agonists Phase 3,Not Applicable
28
Dopamine Approved 62-31-7, 51-61-6 681
29
Spironolactone Approved ,Not Applicable 1952-01-7, 52-01-7 5833
30
Etomidate Approved Not Applicable 33125-97-2 667484 36339
31
Eplerenone Approved Not Applicable 107724-20-9 443872 150310
32
Amiloride Approved 2609-46-3, 2016-88-8 16231
33
Clarithromycin Approved Not Applicable 81103-11-9 84029
34 Protective Agents
35 Cardiotonic Agents
36 Dopamine Agents
37 Natriuretic Agents ,Not Applicable
38 diuretics ,Not Applicable
39 Diuretics, Potassium Sparing ,Not Applicable
40 Hormone Antagonists ,Not Applicable
41 Hormones, Hormone Substitutes, and Hormone Antagonists ,Not Applicable
42 Central Nervous System Depressants Not Applicable
43 Anesthetics, General Not Applicable
44 Metomidate Not Applicable
45 Hypnotics and Sedatives Not Applicable
46 Anesthetics, Intravenous Not Applicable
47 Anesthetics Not Applicable
48 Antihypertensive Agents Not Applicable
49 Anti-Inflammatory Agents Not Applicable
50 Hydrocortisone-17-butyrate Not Applicable

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 SPARTACUS: Subtyping Primary Aldosteronism: a Randomized Trial Comparing Adrenal Vein Sampling and Computed Tomography Scan. Completed NCT01096654 Phase 3
2 D2 Dopamine Receptor on Human Aldosterone-Producing Adenoma and Its Role in Aldosterone Secretion and Cell Proliferation Unknown status NCT00173446
3 Laparoscopic Adrenalectomy Versus Radiofrequency Ablation Unknown status NCT02030587 Not Applicable
4 Postoperative Cardiovascular Index Change of Primary Aldosteronism Unknown status NCT00746070
5 Prevalence of Primary Aldosteronism in Hypertensive Patients Presenting With Atrial Flutter or Fibrillation Unknown status NCT01267747
6 11C-Metomidate PET Versus Adrenal Vein Sampling in Primary Aldosteronism Completed NCT01567111 Not Applicable
7 Arterial Stiffness Index as a Predictor of Surgically Correctable Primary Aldosteronism Completed NCT01190501 Not Applicable
8 Intraoperative Analysis of Cortisol During Adrenal Vein Sampling Completed NCT01761344 Not Applicable
9 Primary Aldosteronism in General Practice: Organ Damage, Epidemiology and Treatment Completed NCT01728493
10 Adrenal Vein Sampling International Study (AVIS Study) Completed NCT01234220
11 Radiofrequency Endoscopic Ablation With Ultrasound Guidance: a Non-surgical Treatment for Aldosterone-producing Adenomas Recruiting NCT03405025 Not Applicable
12 Glucose Metabolism in Subjects With Aldosterone-Producing Adenomas Recruiting NCT02362308 Not Applicable mineralocorticoid receptor antagonist
13 Renal Sympathetic Denervation From The Adventitia on Hypertension Recruiting NCT02642445 Not Applicable
14 IS Metomidate PET-CT Superior to Adrenal Venous Sampling in Predicting Outcome From Adrenalectomy in Patients With Primary Hyperaldosteronism Recruiting NCT02945904
15 Prospective Study Assessing Blood Pressure and Other Outcomes Post-treatment in Patients With Primary Aldosteronism Recruiting NCT03174847 Mineralocorticoid Receptor Antagonists
16 Macrolides for KCNJ5 - Mutated Aldosterone-Producing Adenoma (MAPA) Not yet recruiting NCT03414918 Not Applicable Clarithromycin
17 Rapid Cortisol Assay in Adrenal Vein Sampling Not yet recruiting NCT03449797 Not Applicable

Search NIH Clinical Center for Aldosterone-Producing Adenoma

Genetic Tests for Aldosterone-Producing Adenoma

Anatomical Context for Aldosterone-Producing Adenoma

MalaCards organs/tissues related to Aldosterone-Producing Adenoma:

42
Heart, Adrenal Gland, Kidney, Cortex, Testes, Adrenal Cortex, Spleen

Publications for Aldosterone-Producing Adenoma

Articles related to Aldosterone-Producing Adenoma:

(show top 50) (show all 199)
# Title Authors Year
1
miRNA299 involvement in CYP11B2 expression in aldosterone-producing adenoma. ( 31096184 )
2019
2
Efficient screening of patients with aldosterone-producing adenoma using the ACTH stimulation test. ( 30622316 )
2019
3
Proteomic Landscape of Aldosterone-Producing Adenoma. ( 30580688 )
2018
4
Tumor Cell Subtypes Based on the Intracellular Hormonal Activity in KCNJ5-Mutated Aldosterone-Producing Adenoma. ( 30354756 )
2018
5
Primary hyperaldosteronism induced by aldosterone-producing adenoma co-existing with a left suprarenal accessory spleen: two case reports and a review of the literature. ( 30120761 )
2018
6
The Biology of Normal Zona Glomerulosa and Aldosterone-Producing Adenoma: Pathological Implications. ( 30007283 )
2018
7
Aldosterone Suppression by Dexamethasone in Patients With KCNJ5-Mutated Aldosterone-Producing Adenoma. ( 30020487 )
2018
8
A pedunculated aldosterone-producing adenoma drained by an extra vein causing puzzling results of adrenal vein sampling. ( 29741297 )
2018
9
Macrolides for KCNJ5-mutated aldosterone-producing adenoma (MAPA): design of a study for personalized diagnosis of primary aldosteronism. ( 29409357 )
2018
10
The angiotensin type 2 receptor in the human adrenocortical zona glomerulosa and in aldosterone-producing adenoma: low expression and no functional role. ( 29436482 )
2018
11
Mineralocorticoid receptor antagonism protects the aorta from vascular smooth muscle cell proliferation and collagen deposition in a rat model of adrenal aldosterone-producing adenoma. ( 29164516 )
2018
12
GSTA1 Expression Is Correlated With Aldosterone Level in KCNJ5-Mutated Adrenal Aldosterone-Producing Adenoma. ( 29165597 )
2018
13
Targeting CXCR4 (CXC Chemokine Receptor Type 4) for Molecular Imaging of Aldosterone-Producing Adenoma. ( 29279316 )
2018
14
Purkinje Cell Protein 4 Expression Is Associated With DNA Methylation Status in Aldosterone-Producing Adenoma. ( 29294065 )
2018
15
KCNJ5 mutation as a predictor for resolution of hypertension after surgical treatment of aldosterone-producing adenoma. ( 29016532 )
2018
16
Inflammation and Fibrosis in Perirenal Adipose Tissue of Patients With Aldosterone-Producing Adenoma. ( 29059354 )
2018
17
Calneuron 1 Increased Ca2+ in the Endoplasmic Reticulum and Aldosterone Production in Aldosterone-Producing Adenoma. ( 29109191 )
2018
18
Aberrant G protein-receptor expression is associated with DNA methylation in aldosterone-producing adenoma. ( 28870781 )
2018
19
A Novel Case of Somatic KCNJ5 Mutation in Pediatric-Onset Aldosterone-Producing Adenoma. ( 29264557 )
2017
20
Favorable surgical outcomes of aldosterone-producing adenoma based on lateralization by CT imaging and hypokalemia: a non-AVS-based strategy. ( 28918446 )
2017
21
Review of Markers of Zona Glomerulosa and Aldosterone-Producing Adenoma Cells. ( 28947616 )
2017
22
CTNNB1 Mutation in Aldosterone Producing Adenoma. ( 28956362 )
2017
23
Evaluation of Cortisol Production in Aldosterone-Producing Adenoma. ( 29069700 )
2017
24
Quantitative Value of Aldosterone-Renin Ratio for Detection of Aldosterone-Producing Adenoma: The Aldosterone-Renin Ratio for Primary Aldosteronism (AQUARR) Study. ( 28529209 )
2017
25
Macrolides selectively inhibit mutant KCNJ5 potassium channels that cause aldosterone-producing adenoma. ( 28604387 )
2017
26
Arterial stiffness and blood pressure improvement in aldosterone-producing adenoma harboring KCNJ5 mutations after adrenalectomy. ( 28415786 )
2017
27
Expression and Histopathological Significance of Disabled-2 in Aldosterone-Producing Adenoma. ( 28514805 )
2017
28
Aldosterone-Producing Adenoma With a Somatic KCNJ5 Mutation Revealing APC-Dependent Familial Adenomatous Polyposis. ( 27648962 )
2016
29
Is Laparoendoscopic Single-Site Adrenalectomy a Feasible Alternative in Treating Aldosterone-Producing Adenoma? ( 27975056 )
2016
30
Aldosterone-producing Adenoma in Primary Aldosteronism: CT-guided Radiofrequency Ablation-Long-term Results and Recurrence Rate. ( 27232638 )
2016
31
Hypomethylation of CYP11B2 in Aldosterone-Producing Adenoma. ( 27754862 )
2016
32
Clinical Outcomes following Percutaneous Radiofrequency Ablation of Unilateral Aldosterone-Producing Adenoma: Comparison with Adrenalectomy. ( 27241391 )
2016
33
Comparison of radiofrequency ablation versus laparoscopic adrenalectomy for benign aldosterone-producing adenoma. ( 27300650 )
2016
34
Radiofrequency ablation compared with laparoscopic adrenalectomy for aldosterone-producing adenoma. ( 27511444 )
2016
35
Role of Nox2 and p22phox in Persistent Postoperative Hypertension in Aldosterone-Producing Adenoma Patients after Adrenalectomy. ( 27057164 )
2016
36
Gonadotropin-Releasing Hormone Stimulate Aldosterone Production in a Subset of Aldosterone-Producing Adenoma. ( 27196470 )
2016
37
Time course and factors predicting arterial stiffness reversal in patients with aldosterone-producing adenoma after adrenalectomy: prospective study of 102 patients. ( 26883298 )
2016
38
Intratumoral heterogeneity of steroidogenesis in aldosterone-producing adenoma revealed by intensive double- and triple-immunostaining for CYP11B2/B1 and CYP17. ( 26597777 )
2016
39
Genetics of Aldosterone-Producing Adenoma in Korean Patients. ( 26807823 )
2016
40
PTH Is a Promising Auxiliary Index for the Clinical Diagnosis of Aldosterone-Producing Adenoma. ( 26304960 )
2016
41
Effect of Treatment on Body Fluid in Patients with Unilateral Aldosterone Producing Adenoma: Adrenalectomy versus Spironolactone. ( 26477337 )
2015
42
A Novel Somatic Deletion Mutation of ATP2B3 in Aldosterone-Producing Adenoma. ( 26481629 )
2015
43
Normoaldosteronemic aldosterone-producing adenoma: immunochemical characterization and diagnostic implications. ( 26536091 )
2015
44
Different Somatic Mutations in Multinodular Adrenals With Aldosterone-Producing Adenoma. ( 26351028 )
2015
45
Prevalence and clinical correlates of somatic mutation in aldosterone producing adenoma-Taiwanese population. ( 26066391 )
2015
46
A Meta-Analysis of Somatic KCNJ5 K(+) Channel Mutations In 1636 Patients With an Aldosterone-Producing Adenoma. ( 26066531 )
2015
47
Molecular and Cellular Mechanisms of Aldosterone Producing Adenoma Development. ( 26124749 )
2015
48
Clinical risk factors of postoperative hyperkalemia after adrenalectomy in patients with aldosterone-producing adenoma. ( 25766046 )
2015
49
Prevalence and characterization of somatic mutations in Chinese aldosterone-producing adenoma patients. ( 25906099 )
2015
50
Functional histopathological markers of aldosterone producing adenoma and somatic KCNJ5 mutations. ( 25617716 )
2015

Variations for Aldosterone-Producing Adenoma

Expression for Aldosterone-Producing Adenoma

Search GEO for disease gene expression data for Aldosterone-Producing Adenoma.

Pathways for Aldosterone-Producing Adenoma

Pathways related to Aldosterone-Producing Adenoma according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.38 ATP1A1 ATP2B3 CACNA1D
2
Show member pathways
12.11 ATP1A1 ATP2B3 CACNA1D KCNJ5
3
Show member pathways
12.03 ATP2B3 CACNA1D KCNJ5
4
Show member pathways
11.97 ATP1A1 ATP2B3 CACNA1D CYP11B2 CYP21A2 KCNJ5
5 11.76 ATP1A1 ATP2B3 CACNA1D
6
Show member pathways
11.63 ATP1A1 CACNA1D
7 11.58 CACNA1D KCNJ5
8 11.5 ATP1A1 ATP2B3
9
Show member pathways
11.44 CYP11B2 CYP21A2
10 11.35 ATP1A1 CACNA1D
11
Show member pathways
11.25 CYP11B2 CYP21A2
12 11.05 ATP1A1 CACNA1D
13 10.88 ATP1A1 CACNA1D KCNJ5
14
Show member pathways
10.66 CYP11B2 CYP21A2

GO Terms for Aldosterone-Producing Adenoma

Cellular components related to Aldosterone-Producing Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular vesicle GO:1903561 8.96 ATP1A1 ATP2B3
2 T-tubule GO:0030315 8.62 ATP1A1 KCNJ5

Biological processes related to Aldosterone-Producing Adenoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.56 ATP1A1 ATP2B3 CACNA1D KCNJ5
2 calcium ion transport GO:0006816 9.51 ATP2B3 CACNA1D
3 potassium ion transport GO:0006813 9.49 ATP1A1 KCNJ5
4 calcium ion transmembrane transport GO:0070588 9.48 ATP2B3 CACNA1D
5 steroid metabolic process GO:0008202 9.46 CYP11B2 CYP21A2
6 steroid biosynthetic process GO:0006694 9.43 CYP11B2 CYP21A2
7 potassium ion import across plasma membrane GO:1990573 9.4 ATP1A1 KCNJ5
8 regulation of heart rate by cardiac conduction GO:0086091 9.37 CACNA1D KCNJ5
9 sterol metabolic process GO:0016125 9.32 CYP11B2 CYP21A2
10 cardiac muscle cell action potential involved in contraction GO:0086002 9.16 ATP1A1 CACNA1D
11 glucocorticoid biosynthetic process GO:0006704 8.96 CYP11B2 CYP21A2
12 mineralocorticoid biosynthetic process GO:0006705 8.62 CYP11B2 CYP21A2

Molecular functions related to Aldosterone-Producing Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 9.65 ATP1A1 ATP2B3 CACNA1D CYP11B2 CYP21A2
2 heme binding GO:0020037 9.4 CYP11B2 CYP21A2
3 iron ion binding GO:0005506 9.37 CYP11B2 CYP21A2
4 voltage-gated ion channel activity GO:0005244 9.32 CACNA1D KCNJ5
5 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.16 CYP11B2 CYP21A2
6 steroid hydroxylase activity GO:0008395 8.96 CYP11B2 CYP21A2
7 ankyrin binding GO:0030506 8.62 ATP1A1 CACNA1D

Sources for Aldosterone-Producing Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....