MCID: ALD013
MIFTS: 39

Aldosterone-Producing Adenoma

Categories: Blood diseases, Endocrine diseases

Aliases & Classifications for Aldosterone-Producing Adenoma

MalaCards integrated aliases for Aldosterone-Producing Adenoma:

Name: Aldosterone-Producing Adenoma 25 17
Conn Adenoma 25 71
Primary Aldosteronism Due to Conn Adenoma 25
Aldosterone-Secreting Adenoma 25
Aldosteronoma 25

Classifications:



External Ids:

UMLS 71 C0009777

Summaries for Aldosterone-Producing Adenoma

Genetics Home Reference : 25 An aldosterone-producing adenoma is a noncancerous (benign) tumor that develops in an adrenal gland, which is a small hormone-producing gland located on top of each kidney. In most cases, individuals develop a single tumor in one of the adrenal glands. The adrenal tumor produces too much of the hormone aldosterone, which is a condition known as primary hyperaldosteronism. Aldosterone helps regulate the body's fluid levels and blood pressure by controlling the amount of salt retained by the kidneys. Excess aldosterone causes the kidneys to retain more salt than normal, which increases the body's fluid levels and blood pressure. People with an aldosterone-producing adenoma may develop severe high blood pressure (hypertension), and they have an increased risk of heart attack, stroke, or an irregular heart beat (atrial fibrillation).

MalaCards based summary : Aldosterone-Producing Adenoma, also known as conn adenoma, is related to hypokalemia and familial hyperaldosteronism. An important gene associated with Aldosterone-Producing Adenoma is KCNJ5 (Potassium Inwardly Rectifying Channel Subfamily J Member 5), and among its related pathways/superpathways are Cardiac conduction and cGMP-PKG signaling pathway. The drugs Dopamine and Bromocriptine have been mentioned in the context of this disorder. Affiliated tissues include heart, adrenal gland and kidney, and related phenotype is cardiovascular system.

Wikipedia : 74 Primary aldosteronism (PA), also known as primary hyperaldosteronism or Conn's syndrome, refers to the... more...

Related Diseases for Aldosterone-Producing Adenoma

Diseases related to Aldosterone-Producing Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 106)
# Related Disease Score Top Affiliating Genes
1 hypokalemia 30.8 KCNJ5 CACNA1D
2 familial hyperaldosteronism 30.6 KCNJ5 CYP11B2
3 conn's syndrome 30.3 KCNJ5 CYP21A2 CYP11B2 CACNA1D ATP2B3 ATP1A1
4 adrenal cortical carcinoma 30.0 KCNJ5 CYP21A2 CYP11B2
5 adenoma 30.0 KCNJ5 CYP21A2 CYP11B2 ATP2B3 ATP1A1
6 46,xy sex reversal 2 29.9 CYP21A2 CYP11B2
7 adrenal adenoma 29.1 KCNJ5 CYP21A2 CYP11B2 ATP2B3 ATP1A1
8 hypertension, essential 28.9 KCNJ5 CYP11B2 CACNA1D ATP2B3 ATP1A1
9 adrenal carcinoma 28.7 KCNJ5 CYP21A2 CYP11B2 ATP2B3
10 hyperaldosteronism, familial, type i 28.2 KCNJ5 CYP11B2 CACNA1D ATP2B3 ATP1A1
11 hyperaldosteronism, familial, type ii 11.5
12 adrenal cortical adenoma 10.5
13 pheochromocytoma 10.5
14 adrenal gland pheochromocytoma 10.5
15 adrenocortical carcinoma, hereditary 10.3
16 adrenal cortical adenocarcinoma 10.3
17 malignant hypertension 10.3
18 kidney cancer 10.3
19 adrenal hyperplasia, congenital, due to 3-beta-hydroxysteroid dehydrogenase 2 deficiency 10.2
20 acth-independent macronodular adrenal hyperplasia 10.2
21 glucose intolerance 10.2
22 hyperparathyroidism 10.2
23 congestive heart failure 10.2
24 hypoaldosteronism 10.2
25 periodic paralysis 10.2
26 amenorrhea 10.1
27 pure autonomic failure 10.0
28 hypoxia 10.0
29 diabetes mellitus, noninsulin-dependent 10.0
30 hypokalemic periodic paralysis, type 1 10.0
31 liddle syndrome 1 10.0
32 retinoblastoma 10.0
33 apparent mineralocorticoid excess 10.0
34 pituitary adenoma, prolactin-secreting 10.0
35 hyperaldosteronism, familial, type iii 10.0
36 primary aldosteronism, seizures, and neurologic abnormalities 10.0
37 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 10.0
38 familial adenomatous polyposis 10.0
39 sleep apnea 10.0
40 pre-eclampsia 10.0
41 portal hypertension 10.0
42 primary hyperparathyroidism 10.0
43 heart disease 10.0
44 hepatic coma 10.0
45 hepatic encephalopathy 10.0
46 renovascular hypertension 10.0
47 pneumothorax 10.0
48 glomerulonephritis 10.0
49 anuria 10.0
50 multiple endocrine neoplasia 10.0

Graphical network of the top 20 diseases related to Aldosterone-Producing Adenoma:



Diseases related to Aldosterone-Producing Adenoma

Symptoms & Phenotypes for Aldosterone-Producing Adenoma

MGI Mouse Phenotypes related to Aldosterone-Producing Adenoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.02 ATP1A1 ATP2B3 CACNA1D CYP11B2 KCNJ5

Drugs & Therapeutics for Aldosterone-Producing Adenoma

Drugs for Aldosterone-Producing Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 74)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
2
Bromocriptine Approved, Investigational Phase 4 25614-03-3 31101
3
Zinc Approved, Investigational Phase 4 7440-66-6 32051
4
Nitric Oxide Approved Phase 4 10102-43-9 145068
5 Dopamine agonists Phase 4
6 Dopamine Agents Phase 4
7 Antiparkinson Agents Phase 4
8 Insulin, Globin Zinc Phase 4
9 Pharmaceutical Solutions Phase 4
10 Hypoglycemic Agents Phase 4
11 insulin Phase 4
12 Kava Approved, Investigational, Nutraceutical Phase 3 9000-38-8
13 Mineralocorticoid Receptor Antagonists Phase 3
14 Mineralocorticoids Phase 3
15 Adrenocorticotropic Hormone Phase 3
16 Melanocyte-Stimulating Hormones Phase 3
17 beta-Endorphin Phase 3
18
Everolimus Approved Phase 2 159351-69-6 70789204 6442177
19
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
20
Amlodipine Approved Phase 2 88150-42-9 2162
21 Immunosuppressive Agents Phase 2
22 Immunologic Factors Phase 2
23 Antihypertensive Agents Phase 2
24 Hormones Phase 2
25 Vasodilator Agents Phase 2
26 Calcium, Dietary Phase 2
27 calcium channel blockers Phase 2
28
Calcium Nutraceutical Phase 2 7440-70-2 271
29
Clarithromycin Approved 81103-11-9 84029
30
Captopril Approved 62571-86-2 44093
31
Olmesartan Approved, Investigational 144689-24-7, 144689-63-4 158781 130881
32
Angiotensin II Approved, Investigational 4474-91-3, 11128-99-7, 68521-88-0 172198
33
Spironolactone Approved 52-01-7, 1952-01-7 5833
34
Eplerenone Approved 107724-20-9 150310 443872
35
Ethanol Approved 64-17-5 702
36
Epinephrine Approved, Vet_approved 51-43-4 5816
37
Racepinephrine Approved 329-65-7 838
38
Hydrocortisone Approved, Vet_approved 50-23-7 5754
39
Hydrocortisone acetate Approved, Vet_approved 50-03-3
40
Canrenone Investigational 976-71-6 13789
41 Cytochrome P-450 Enzyme Inhibitors
42 Anti-Infective Agents
43 Cytochrome P-450 CYP3A Inhibitors
44 Anti-Bacterial Agents
45
protease inhibitors
46 HIV Protease Inhibitors
47 Hypnotics and Sedatives
48 Metomidate
49 Hormone Antagonists
50 diuretics

Interventional clinical trials:

(show all 26)
# Name Status NCT ID Phase Drugs
1 The Therapeutic Effect of Bromocriptin in Patients With Primary Aldosteronism Unknown status NCT00451672 Phase 4 bromocriptine
2 The Role of Aldosterone on Sympathetic Nerve Activity and Insulin Sensitivity Recruiting NCT02102243 Phase 4 DEFINITY® infusion;Human Recombinant Regular Insulin infusion;Dextrose infusion
3 Towards Cost-effective Management of Patients With Hypertension Due to Primary Aldosteronism: Adrenal Vein Sampling or Ct-scan? Completed NCT01096654 Phase 3
4 Open-label Study on Treatment of Primary Aldosteronism With Everolimus Completed NCT03174171 Phase 2 Everolimus 0.75 mg
5 Calcium Channel Blockade in Primary Aldosteronism Not yet recruiting NCT04179019 Phase 2 Amlodipine
6 Expression of D2-Like Dopamine Receptor of Human Aldosterone-Producing Adenoma and Its Role in Regulation of Aldosterone Secretion and Cell Proliferation Unknown status NCT00173446
7 Laparoscopic Adrenalectomy Versus Radiofrequency Ablation for Aldosterone-producing Adenoma: a Prospective Randomized Controlled Trial Unknown status NCT02030587
8 Macrolides for KCNJ5 - Mutated Aldosterone-Producing Adenoma (MAPA): A Study Of Personalized Diagnosis of Primary Aldosteronism With Implications For Treatment Unknown status NCT03414918 Clarithromycin
9 Aldosterone-Renin Ratio to Diagnose Primary Aldosteronism in a Population of Patients With Therapy-Resistant Hypertension: Test Characteristics, Diagnostic Value and Predictive Value for Antihypertensive Treatment. The Dutch ARRAT Study. Unknown status NCT00407784 eplerenone
10 Postoperative Cardiovascular Index Change of Primary Aldosteronism Unknown status NCT00746070
11 Diagnosis of Primary Aldosteronism: Comparison of Post Captopril Active Renin Concentration and Plasma Renin Activity Unknown status NCT00917345 captopril test
12 Arterial Stiffness Index as a Predictor of Surgically Correctable Primary Aldosteronism Completed NCT01190501
13 Functional Imaging With 11C-Metomidate Positron Emission Tomography Versus Adrenal Vein Sampling in Differential Diagnosis of Unilateral and Bilateral Aldosterone Secretion in Primary Aldosteronism Completed NCT01567111
14 Intraoperative Analysis of Cortisol During Adrenal Vein Catheterization and Sampling in Patients With Primary Hyperaldosteronism. Completed NCT01761344
15 Primary Aldosteronism in General Practice: Organ Damage, Epidemiology and Treatment Completed NCT01728493
16 Radiofrequency Ablation for Aldosterone-producting Adenoma in Patients With Primary Aldosteronism: Evaluation of the Blood Pressure Control and of Its Safety. Completed NCT02756754
17 Usefulness of the Ipsilateral and Contralateral Index for the Interpretation of Adrenal Vein Sampling (AVS) in the Subtype Diagnosis of Primary Aldosteronism Completed NCT04378387
18 Prospective Assessment of The Prevalence of Primary Aldosteronism in Hypertensive Patients Presenting With Atrial Flutter or Fibrillation Completed NCT01267747
19 Effects of Mineralocorticoid and AT-1 Receptor Antagonism on the Aldosterone-Renin Ratio (ARR) In Primary Aldosteronism Patients (EMIRA Study): Rationale and Design Completed NCT04185857 canrenone 50-100 mg orally once a day;olmesartan 10-20 mg orally once a day
20 Multicenter Study on Use and Interpretation of Adrenal Vein Sampling Completed NCT01234220
21 Changes in Tissue Potassium Amount Before and After Treatment of Primary Hyperaldosteronism Assessed by 39K-MRI Recruiting NCT04251780 Drug treatment of Hyperaldosteronism
22 Efficacy and Safety of Renal Sympathetic Denervation From The Adventitia on Hypertension in Patients With Primary Aldosteronism Recruiting NCT02642445
23 Feasibility Study of RadioFrequency Endoscopic ABlation, With ULtrasound Guidance, as a Non-surgical, Adrenal Sparing Treatment for Aldosterone-producing Adenomas Recruiting NCT03405025
24 Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks Recruiting NCT03374215
25 An Parallel Control Clinical Trail on Effects of Adrenal Artery Ablation and Adrenalectomy in Patients With Primary Aldosteronism Recruiting NCT04269928
26 The Intra-Procedural Cortisol Assay During Adrenal Vein Sampling: Rationale andDesign of A Randomized Study (I-PADUA) Not yet recruiting NCT03449797

Search NIH Clinical Center for Aldosterone-Producing Adenoma

Genetic Tests for Aldosterone-Producing Adenoma

Anatomical Context for Aldosterone-Producing Adenoma

MalaCards organs/tissues related to Aldosterone-Producing Adenoma:

40
Heart, Adrenal Gland, Kidney, Testes, Cortex, Adrenal Cortex, Endothelial

Publications for Aldosterone-Producing Adenoma

Articles related to Aldosterone-Producing Adenoma:

(show top 50) (show all 904)
# Title Authors PMID Year
1
Primary antiphospholipid syndrome, Addison disease, and adrenal incidentaloma. 61
32146613 2020
2
Age, Gender, and Body Mass Index as Determinants of Surgical Outcome in Primary Aldosteronism. 61
32252109 2020
3
Hemodynamics of primary aldosteronism associated with adrenocortical adenoma: Insights from bioimpedance cardiography measurements. 61
32533871 2020
4
Angiotensin II Type 1 Receptor Autoantibodies in Primary Aldosteronism. 61
32168525 2020
5
Hypokalemia and the Prevalence of Primary Aldosteronism. 61
32252108 2020
6
Appropriate timing for a biochemical evaluation after adrenalectomy for unilateral aldosterone-producing adenoma. 61
32068902 2020
7
Insulin secretion and sensitivity before and after surgical treatment for aldosterone-producing adenoma. 61
31676325 2020
8
Impact of immunohistochemistry on the diagnosis and management of primary aldosteronism: An important tool for improved patient follow-up. 61
30654730 2020
9
MicroRNAs and Adrenocortical Tumors: Where do we Stand on Primary Aldosteronism? 61
32168526 2020
10
Developments in Primary Aldosteronism Subtyping Using Steroid Profiling. 61
32330948 2020
11
Genetic and Genomic Mechanisms of Primary Aldosteronism. 61
32563556 2020
12
Immunohistochemistry of the Human Adrenal CYP11B2 in Normal Individuals and in Patients with Primary Aldosteronism. 61
32289837 2020
13
Precise Mapping of Intra-Adrenal Aldosterone Activities Provides a Novel Surgical Strategy for Primary Aldosteronism. 61
32536272 2020
14
Role of Mast Cells in the Control of Aldosterone Secretion. 61
32215882 2020
15
Primary aldosteronism in a general population sample. The Czech post-MONICA study. 61
32036692 2020
16
Prevalence of primary aldosteronism and association with cardiovascular complications in patients with resistant and refractory hypertension. 61
32384388 2020
17
Lipoprotein insulin resistance score and branched-chain amino acids increase after adrenalectomy for unilateral aldosterone-producing adenoma: a preliminary study. 61
32133607 2020
18
Different pathogenesis of glucose intolerance in two subtypes of primary aldosteronism: aldosterone-producing adenoma and idiopathic hyperaldosteronism. 61
32470155 2020
19
[Clinical Characteristics of Aldosterone Producing Adenoma and Idiopathic Hyperaldosteronism with Obstructive Sleep Apnea Hypopnea Syndrome]. 61
32543133 2020
20
[The Value of Serum Potassium and Ratio of Sodium to Potassium after Saline Infusion Test in Differential Diagnosis of Primary Hyperaldosteronism]. 61
32543131 2020
21
EXPLORATION OF THE SEATED SALINE SUPPRESSION TEST FOR THE DIAGNOSIS OF PRIMARY ALDOSTERONISM IN CHINESE POPULATION. 61
32339027 2020
22
Primary and Secondary Hyperparathyroidism in Patients with Primary Aldosteronism - Findings From the German Conn's Registry. 61
31698477 2020
23
Reliability of adrenal computed tomography in predicting the functionality of adrenal incidentaloma. 61
32295940 2020
24
Genetic, Cellular, and Molecular Heterogeneity in Adrenals With Aldosterone-Producing Adenoma. 61
32114847 2020
25
Long-Term Results of Laparoscopic Partial Versus Total Adrenalectomy for Aldosterone Producing Adenoma. 61
32309875 2020
26
Evaluation of various confirmatory tests for the diagnosis of aldosterone-producing adenoma. 61
32370649 2020
27
Somatic CACNA1H Mutation As a Cause of Aldosterone-Producing Adenoma. 61
31983310 2020
28
A clinical prediction score using age at diagnosis and saline infusion test parameters can predict aldosterone-producing adenoma from idiopathic adrenal hyperplasia. 61
31529391 2020
29
Old and new genes in primary aldosteronism. 61
32007424 2020
30
Immediate Results and Long-Term Outcomes Following Percutaneous Radiofrequency Ablation of Unilateral Aldosterone-Producing Adenoma. 61
32201467 2020
31
Imaging CXCR4 expression in patients with suspected primary hyperaldosteronism. 61
32206838 2020
32
The risk factors for hepatic steatosis in patients with primary aldosteronism. 61
32213734 2020
33
Prevalence, diagnosis and outcomes of treatment for primary aldosteronism. 61
31837980 2020
34
Primary aldosteronism diagnostics: KCNJ5 mutations and hybrid steroid synthesis in aldosterone-producing adenomas. 61
32206594 2020
35
Surgery decreases the long-term incident stroke risk in patients with primary aldosteronism. 61
31676114 2020
36
Molecular and Electrophysiological Analyses of ATP2B4 Gene Variants in Bilateral Adrenal Hyperaldosteronism. 61
32002807 2020
37
Endoplasmic Reticulum Chaperone Calmegin Is Upregulated in Aldosterone-Producing Adenoma and Associates With Aldosterone Production. 61
31865789 2020
38
Persistent severe hyperkalemia following surgical treatment of aldosterone-producing adenoma. 61
32174989 2020
39
[The Value of Postural Stimulation Test Combined with Adrenal CT in the Diagnosis of Aldosterone-producing Adenoma]. 61
31950795 2020
40
The Effects of Different Calcium Channel Blockers on Aldosterone-Producing Adenoma Cells. 61
32411097 2020
41
L- and T-type calcium channels control aldosterone production from human adrenals. 61
31652415 2020
42
Aldosterone Stimulates Its Biosynthesis Via a Novel GPER-Mediated Mechanism. 61
31125081 2019
43
Molecular Mechanisms of Primary Aldosteronism. 61
31884735 2019
44
[Primary aldosteronism : Genetics and pathology]. 61
31705237 2019
45
Primary aldosteronism in Klinefelter's syndrome: two cases. 61
31841437 2019
46
Elevated Plasma Renin Activity Caused by Accelerated-malignant Hypertension in a Patient with Aldosterone-producing Adenoma Complicated with Renal Insufficiency. 61
31292373 2019
47
Genetic causes of primary aldosteronism. 61
31695023 2019
48
Left Ventricular Dysfunction in Patients With Primary Aldosteronism: A Propensity Score-Matching Follow-Up Study With Tissue Doppler Imaging. 61
31718437 2019
49
A somatic mutation in CLCN2 identified in a sporadic aldosterone-producing adenoma. 61
31491746 2019
50
Genetic and epigenetic analyses of aldosterone-producing adenoma with hypercortisolemia. 61
31400391 2019

Variations for Aldosterone-Producing Adenoma

Expression for Aldosterone-Producing Adenoma

Search GEO for disease gene expression data for Aldosterone-Producing Adenoma.

Pathways for Aldosterone-Producing Adenoma

Pathways related to Aldosterone-Producing Adenoma according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.41 CACNA1D ATP2B3 ATP1A1
2
Show member pathways
12.04 CACNA1D ATP2B3 ATP1A1
3
Show member pathways
11.99 KCNJ5 CACNA1D ATP2B3
4
Show member pathways
11.87 KCNJ5 CYP21A2 CYP11B2 CACNA1D ATP2B3 ATP1A1
5 11.77 CACNA1D ATP2B3 ATP1A1
6
Show member pathways
11.66 CACNA1D ATP1A1
7 11.62 KCNJ5 CACNA1D
8 11.56 ATP2B3 ATP1A1
9
Show member pathways
11.48 CYP21A2 CYP11B2
10 11.46 CACNA1D ATP1A1
11
Show member pathways
11.32 CYP21A2 CYP11B2
12 11.28 KCNJ5 CACNA1D
13 11.22 ATP2B3 ATP1A1
14 11.16 ATP2B3 ATP1A1
15 11.08 CACNA1D ATP1A1
16 10.88 KCNJ5 CACNA1D ATP1A1
17
Show member pathways
10.5 CYP21A2 CYP11B2

GO Terms for Aldosterone-Producing Adenoma

Cellular components related to Aldosterone-Producing Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 organelle membrane GO:0031090 8.96 CYP21A2 ATP1A1
2 T-tubule GO:0030315 8.62 KCNJ5 ATP1A1

Biological processes related to Aldosterone-Producing Adenoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.56 KCNJ5 CACNA1D ATP2B3 ATP1A1
2 ion transmembrane transport GO:0034220 9.54 CACNA1D ATP2B3 ATP1A1
3 calcium ion transmembrane transport GO:0070588 9.51 CACNA1D ATP2B3
4 steroid metabolic process GO:0008202 9.49 CYP21A2 CYP11B2
5 steroid biosynthetic process GO:0006694 9.48 CYP21A2 CYP11B2
6 regulation of cardiac conduction GO:1903779 9.46 ATP2B3 ATP1A1
7 potassium ion import across plasma membrane GO:1990573 9.43 KCNJ5 ATP1A1
8 regulation of heart rate by cardiac conduction GO:0086091 9.4 KCNJ5 CACNA1D
9 sterol metabolic process GO:0016125 9.32 CYP21A2 CYP11B2
10 cardiac muscle cell action potential involved in contraction GO:0086002 9.16 CACNA1D ATP1A1
11 glucocorticoid biosynthetic process GO:0006704 8.96 CYP21A2 CYP11B2
12 mineralocorticoid biosynthetic process GO:0006705 8.62 CYP21A2 CYP11B2

Molecular functions related to Aldosterone-Producing Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 9.72 CYP21A2 CYP11B2 CACNA1D ATP2B3 ATP1A1
2 monooxygenase activity GO:0004497 9.26 CYP21A2 CYP11B2
3 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.16 CYP21A2 CYP11B2
4 steroid hydroxylase activity GO:0008395 8.96 CYP21A2 CYP11B2
5 ankyrin binding GO:0030506 8.62 CACNA1D ATP1A1

Sources for Aldosterone-Producing Adenoma

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