MCID: ALD013
MIFTS: 39

Aldosterone-Producing Adenoma

Categories: Blood diseases, Endocrine diseases

Aliases & Classifications for Aldosterone-Producing Adenoma

MalaCards integrated aliases for Aldosterone-Producing Adenoma:

Name: Aldosterone-Producing Adenoma 25 17
Conn Adenoma 25 72
Primary Aldosteronism Due to Conn Adenoma 25
Aldosterone-Secreting Adenoma 25
Aldosteronoma 25

Classifications:



External Ids:

UMLS 72 C0009777

Summaries for Aldosterone-Producing Adenoma

Genetics Home Reference : 25 An aldosterone-producing adenoma is a noncancerous (benign) tumor that develops in an adrenal gland, which is a small hormone-producing gland located on top of each kidney. In most cases, individuals develop a single tumor in one of the adrenal glands. The adrenal tumor produces too much of the hormone aldosterone, which is a condition known as primary hyperaldosteronism. Aldosterone helps regulate the body's fluid levels and blood pressure by controlling the amount of salt retained by the kidneys. Excess aldosterone causes the kidneys to retain more salt than normal, which increases the body's fluid levels and blood pressure. People with an aldosterone-producing adenoma may develop severe high blood pressure (hypertension), and they have an increased risk of heart attack, stroke, or an irregular heart beat (atrial fibrillation).

MalaCards based summary : Aldosterone-Producing Adenoma, also known as conn adenoma, is related to conn's syndrome and adenoma. An important gene associated with Aldosterone-Producing Adenoma is KCNJ5 (Potassium Inwardly Rectifying Channel Subfamily J Member 5), and among its related pathways/superpathways are Cardiac conduction and Myometrial Relaxation and Contraction Pathways. The drugs Dopamine and Bromocriptine have been mentioned in the context of this disorder. Affiliated tissues include heart, adrenal gland and kidney.

Wikipedia : 75 Primary aldosteronism, also known as primary hyperaldosteronism or Conn's syndrome, refers to the excess... more...

Related Diseases for Aldosterone-Producing Adenoma

Diseases related to Aldosterone-Producing Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 conn's syndrome 32.5 KCNJ5 CYP21A2 CYP11B2
2 adenoma 31.5 KCNJ5 CYP21A2 CYP11B2
3 adrenal adenoma 30.6 KCNJ5 CYP21A2 CYP11B2
4 familial hyperaldosteronism 30.3 KCNJ5 CYP11B2
5 adrenal carcinoma 29.8 CYP21A2 CYP11B2
6 adrenocortical carcinoma, hereditary 29.7 CYP21A2 CYP11B2
7 hyperaldosteronism, familial, type ii 11.5
8 hypokalemia 10.8
9 hypertension, essential 10.7
10 adrenal cortical adenoma 10.5
11 pheochromocytoma 10.5
12 adrenal gland pheochromocytoma 10.5
13 adrenal cortical carcinoma 10.3
14 malignant hypertension 10.3
15 kidney cancer 10.3
16 adrenal cortical adenocarcinoma 10.3
17 hyperaldosteronism, familial, type i 10.2
18 adrenal hyperplasia, congenital, due to 3-beta-hydroxysteroid dehydrogenase 2 deficiency 10.2
19 acth-independent macronodular adrenal hyperplasia 10.2
20 hyperparathyroidism 10.2
21 adrenal cortex disease 10.1 KCNJ5 CYP11B2
22 amenorrhea 10.1
23 endocrine organ benign neoplasm 10.1 KCNJ5 CYP11B2
24 pure autonomic failure 10.0
25 hypoxia 10.0
26 diabetes mellitus, noninsulin-dependent 10.0
27 fibrosis of extraocular muscles, congenital, 1 10.0
28 neurofibromatosis, type iv, of riccardi 10.0
29 hypokalemic periodic paralysis, type 1 10.0
30 liddle syndrome 1 10.0
31 retinoblastoma 10.0
32 apparent mineralocorticoid excess 10.0
33 46,xy sex reversal 2 10.0
34 pituitary adenoma, prolactin-secreting 10.0
35 hyperaldosteronism, familial, type iii 10.0
36 primary aldosteronism, seizures, and neurologic abnormalities 10.0
37 immunodeficiency, common variable, 10 10.0
38 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 10.0
39 familial adenomatous polyposis 10.0
40 pre-eclampsia 10.0
41 glucose intolerance 10.0
42 portal hypertension 10.0
43 primary hyperparathyroidism 10.0
44 hepatic coma 10.0
45 hepatic encephalopathy 10.0
46 renovascular hypertension 10.0
47 pneumothorax 10.0
48 glomerulonephritis 10.0
49 anuria 10.0
50 neurilemmoma 10.0

Graphical network of the top 20 diseases related to Aldosterone-Producing Adenoma:



Diseases related to Aldosterone-Producing Adenoma

Symptoms & Phenotypes for Aldosterone-Producing Adenoma

Drugs & Therapeutics for Aldosterone-Producing Adenoma

Drugs for Aldosterone-Producing Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 77)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
2
Bromocriptine Approved, Investigational Phase 4 25614-03-3 31101
3
Nitric Oxide Approved Phase 4 10102-43-9 145068
4
Zinc Approved, Investigational Phase 4 7440-66-6 32051
5 Dopamine Agents Phase 4
6 Hormone Antagonists Phase 4
7 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
8 Antiparkinson Agents Phase 4
9 Dopamine agonists Phase 4
10 Protective Agents Phase 4
11 insulin Phase 4
12 Antioxidants Phase 4
13 Free Radical Scavengers Phase 4
14 Insulin, Globin Zinc Phase 4
15 Pharmaceutical Solutions Phase 4
16 Endothelium-Dependent Relaxing Factors Phase 4
17 Vasodilator Agents Phase 4
18 Hypoglycemic Agents Phase 4
19 Kava Approved, Investigational, Nutraceutical Phase 3 9000-38-8
20 Hormones Phase 3
21 Mineralocorticoid Receptor Antagonists Phase 3
22 Mineralocorticoids Phase 3
23 Adrenocorticotropic Hormone Phase 3
24 Melanocyte-Stimulating Hormones Phase 3
25 beta-endorphin Phase 3
26
Sirolimus Approved, Investigational Phase 2 53123-88-9 6436030 5284616 46835353
27
Everolimus Approved Phase 2 159351-69-6 6442177 70789204
28
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
29 Anti-Infective Agents Phase 2
30 Anti-Bacterial Agents Phase 2
31 Antifungal Agents Phase 2
32 Immunologic Factors Phase 2
33 Antibiotics, Antitubercular Phase 2
34 Immunosuppressive Agents Phase 2
35
Eplerenone Approved 107724-20-9 150310 443872
36
Spironolactone Approved 1952-01-7, 52-01-7 5833
37
Captopril Approved 62571-86-2 44093
38
Etomidate Approved 33125-97-2 36339 667484
39
Epinephrine Approved, Vet_approved 51-43-4 5816
40
Racepinephrine Approved 329-65-7 838
41
Clarithromycin Approved 81103-11-9 84029
42
Hydrocortisone acetate Approved, Vet_approved 50-03-3
43
Hydrocortisone Approved, Vet_approved 50-23-7 5754
44 Cardiotonic Agents
45
protease inhibitors
46 HIV Protease Inhibitors
47 Angiotensin-Converting Enzyme Inhibitors
48 Antihypertensive Agents
49 Anesthetics, Intravenous
50 Central Nervous System Depressants

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 The Therapeutic Effect of Bromocriptin in Patients With Primary Aldosteronism Unknown status NCT00451672 Phase 4 bromocriptine
2 The Role of Aldosterone on Sympathetic Nerve Activity and Insulin Sensitivity Recruiting NCT02102243 Phase 4 DEFINITY® infusion;Human Recombinant Regular Insulin infusion;Dextrose infusion
3 Towards Cost-effective Management of Patients With Hypertension Due to Primary Aldosteronism: Adrenal Vein Sampling or Ct-scan? Completed NCT01096654 Phase 3
4 Open-label Study on Treatment of Primary Aldosteronism With Everolimus Completed NCT03174171 Phase 2 Everolimus 0.75 mg
5 Expression of D2-Like Dopamine Receptor of Human Aldosterone-Producing Adenoma and Its Role in Regulation of Aldosterone Secretion and Cell Proliferation Unknown status NCT00173446
6 Laparoscopic Adrenalectomy Versus Radiofrequency Ablation for Aldosterone-producing Adenoma: a Prospective Randomized Controlled Trial Unknown status NCT02030587
7 Aldosterone-Renin Ratio to Diagnose Primary Aldosteronism in a Population of Patients With Therapy-Resistant Hypertension: Test Characteristics, Diagnostic Value and Predictive Value for Antihypertensive Treatment. The Dutch ARRAT Study. Unknown status NCT00407784 eplerenone
8 Postoperative Cardiovascular Index Change of Primary Aldosteronism Unknown status NCT00746070
9 Diagnosis of Primary Aldosteronism: Comparison of Post Captopril Active Renin Concentration and Plasma Renin Activity Unknown status NCT00917345 captopril test
10 Arterial Stiffness Index as a Predictor of Surgically Correctable Primary Aldosteronism Completed NCT01190501
11 Functional Imaging With 11C-Metomidate Positron Emission Tomography Versus Adrenal Vein Sampling in Differential Diagnosis of Unilateral and Bilateral Aldosterone Secretion in Primary Aldosteronism Completed NCT01567111
12 Intraoperative Analysis of Cortisol During Adrenal Vein Catheterization and Sampling in Patients With Primary Hyperaldosteronism. Completed NCT01761344
13 Primary Aldosteronism in General Practice: Organ Damage, Epidemiology and Treatment Completed NCT01728493
14 Radiofrequency Ablation for Aldosterone-producting Adenoma in Patients With Primary Aldosteronism: Evaluation of the Blood Pressure Control and of Its Safety. Completed NCT02756754
15 Prospective Assessment of The Prevalence of Primary Aldosteronism in Hypertensive Patients Presenting With Atrial Flutter or Fibrillation Completed NCT01267747
16 Multicenter Study on Use and Interpretation of Adrenal Vein Sampling Completed NCT01234220
17 Efficacy and Safety of Renal Sympathetic Denervation From The Adventitia on Hypertension in Patients With Primary Aldosteronism Recruiting NCT02642445
18 Feasibility Study of RadioFrequency Endoscopic ABlation, With ULtrasound Guidance, as a Non-surgical, Adrenal Sparing Treatment for Aldosterone-producing Adenomas Recruiting NCT03405025
19 Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks Recruiting NCT03374215
20 Macrolides for KCNJ5 - Mutated Aldosterone-Producing Adenoma (MAPA): A Study Of Personalized Diagnosis of Primary Aldosteronism With Implications For Treatment Not yet recruiting NCT03414918 Clarithromycin
21 The Intra-Procedural Cortisol Assay During Adrenal Vein Sampling: Rationale andDesign of A Randomized Study (I-PADUA) Not yet recruiting NCT03449797

Search NIH Clinical Center for Aldosterone-Producing Adenoma

Genetic Tests for Aldosterone-Producing Adenoma

Anatomical Context for Aldosterone-Producing Adenoma

MalaCards organs/tissues related to Aldosterone-Producing Adenoma:

41
Heart, Adrenal Gland, Kidney, Testes, Cortex, Adrenal Cortex, Endothelial

Publications for Aldosterone-Producing Adenoma

Articles related to Aldosterone-Producing Adenoma:

(show top 50) (show all 845)
# Title Authors PMID Year
1
PTH Modulation by Aldosterone and Angiotensin II is Blunted in Hyperaldosteronism and Rescued by Adrenalectomy. 38
30865228 2019
2
Molecular mechanisms in primary aldosteronism 38
31397984 2019
3
Genetic and epigenetic analyses of aldosterone-producing adenoma with hypercortisolemia. 38
31400391 2019
4
THE POTENTIAL CLINICAL APPLICATION OF A LOWER BILATERAL ADRENAL LIMB WIDTH RATIO (L/RW) IN PATIENTS WITH BILATERAL PRIMARY HYPERALDOSTERONISM. 38
31013150 2019
5
Impact of laparoscopic adrenalectomy on renal function. Results of a prospective randomized clinical trial. 38
31274187 2019
6
miRNA299 involvement in CYP11B2 expression in aldosterone-producing adenoma. 38
31096184 2019
7
Hypertension with primary aldosteronism is associated with increased carotid intima-media thickness and endothelial dysfunction. 38
31187936 2019
8
Primary adrenal schwannoma: a series of 31 cases emphasizing their clinicopathologic features and favorable prognosis. 38
31278687 2019
9
H-score of 11β-hydroxylase and aldosterone synthase in the histopathological diagnosis of adrenocortical tumors. 38
31332713 2019
10
Elevated Plasma Renin Activity Caused by Accelerated-malignant Hypertension in a Patient with Aldosterone-producing Adenoma Complicated with Renal Insufficiency. 38
31292373 2019
11
18-Oxocortisol Synthesis in Aldosterone-Producing Adrenocortical Adenoma and Significance of KCNJ5 Mutation Status. 38
31006333 2019
12
Adrenalectomy Improves the Long-Term Risk of End-Stage Renal Disease and Mortality of Primary Aldosteronism. 38
31086833 2019
13
Primary Hyperaldosteronism Induced by Aldosterone-Producing Adenoma Co-Existing with A Left Suprarenal Accessory Spleen: Two Case Reports and A Review of The Literature. 38
30120761 2019
14
Efficient screening of patients with aldosterone-producing adenoma using the ACTH stimulation test. 38
30622316 2019
15
A novel clinical nomogram to predict bilateral hyperaldosteronism in Chinese patients with primary aldosteronism. 38
30820995 2019
16
Hypercortisolism and primary aldosteronism caused by bilateral adrenocortical adenomas: a case report. 38
31208392 2019
17
Computed tomography scan can be misleading in the lateralisation of aldosterone excess 38
31368677 2019
18
Adrenal venous sampling: cosyntropin stimulation or not? 38
31176302 2019
19
Plasma aldosterone after seated saline infusion test outperforms captopril test at predicting clinical outcomes after adrenalectomy for primary aldosteronism. 38
31216359 2019
20
Aldosterone Stimulates Its Biosynthesis Via A Novel GPER Mediated Mechanism. 38
31125081 2019
21
Left atrial myocardial dysfunction in patients with primary aldosteronism as assessed by speckle-tracking echocardiography. 38
31157742 2019
22
Eplerenone improves endothelial function and arterial stiffness and inhibits Rho-associated kinase activity in patients with idiopathic hyperaldosteronism: a pilot study. 38
30418321 2019
23
Robot-assisted Partial Adrenalectomy for the Treatment of Conn's Syndrome: Surgical Technique, and Perioperative and Functional Outcomes. 38
30077398 2019
24
Risk of severe erectile dysfunction in primary hyperaldosteronism: A population-based propensity score matching cohort study. 38
30473204 2019
25
10 good reasons why adrenal vein sampling is the preferred method for referring primary aldosteronism patients for adrenalectomy. 38
30431526 2019
26
Proteomic Landscape of Aldosterone-Producing Adenoma. 38
30580688 2019
27
Impact of immunohistochemistry on the diagnosis and management of primary aldosteronism: An important tool for improved patient follow-up. 38
30654730 2019
28
[Primary hyperaldosteronism in a population of hypertensive patients]. 38
31284252 2019
29
Predictors of confirmatory test results for the diagnosis of primary hyperaldosteronism in hypertensive patients with an aldosterone-to-renin ratio greater than 20. The SHRIMP study. 38
30401909 2019
30
Lower connectivity of tumor coexpression networks is not specific to cancer. 38
31156157 2019
31
Speckle-Tracking Echocardiographic Layer-Specific Strain Analysis on Subclinical Left Ventricular Dysfunction in Patients With Primary Aldosteronism. 38
30462153 2019
32
Primary Aldosteronism: Present and Future. 38
30678860 2019
33
Targeted treatment of primary aldosteronism - The consensus of Taiwan Society of Aldosteronism. 38
29506889 2019
34
Cortisol Excess in Patients With Primary Aldosteronism Impacts Left Ventricular Hypertrophy. 38
30113683 2018
35
Obesity as a Key Factor Underlying Idiopathic Hyperaldosteronism. 38
30165444 2018
36
Aldosterone and 18-Oxocortisol Coaccumulation in Aldosterone-Producing Lesions. 38
30571232 2018
37
Simultaneous occurrence of primary aldosteronism due to aldosteronoma and ectopic meningioma in the adrenal gland: A case report. 38
30558028 2018
38
The Biology of Normal Zona Glomerulosa and Aldosterone-Producing Adenoma: Pathological Implications. 38
30007283 2018
39
Risk of sepsis in patients with primary aldosteronism. 38
30463626 2018
40
Microvascular endothelial function is impaired in patients with idiopathic hyperaldosteronism. 38
30206323 2018
41
Relationship Between Visceral Fat and Plasma Aldosterone Concentration in Patients With Primary Aldosteronism. 38
30374468 2018
42
Insufficiency of the zona glomerulosa of the adrenal cortex and progressive kidney insufficiency following unilateral adrenalectomy - case report and discussion. 38
29742971 2018
43
Evaluation of angiotensin II type-1 receptor antibodies in primary aldosteronism and further considerations about their possible pathogenetic role. 38
30058103 2018
44
Tumor Cell Subtypes Based on the Intracellular Hormonal Activity in KCNJ5-Mutated Aldosterone-Producing Adenoma. 38
30354756 2018
45
Aldosterone Suppression by Dexamethasone in Patients With KCNJ5-Mutated Aldosterone-Producing Adenoma. 38
30020487 2018
46
Macrolides for KCNJ5-mutated aldosterone-producing adenoma (MAPA): design of a study for personalized diagnosis of primary aldosteronism. 38
29409357 2018
47
Genetic aspects of primary hyperaldosteronism. 38
29938936 2018
48
Psychological Symptoms and Well-Being After Treatment for Primary Aldosteronism. 38
29895075 2018
49
MANAGEMENT OF ENDOCRINE DISEASE: Diagnosis and management of primary aldosteronism: the Endocrine Society guideline 2016 revisited. 38
29674485 2018
50
Overview of aldosterone-related genetic syndromes and recent advances. 38
29432258 2018

Variations for Aldosterone-Producing Adenoma

Expression for Aldosterone-Producing Adenoma

Search GEO for disease gene expression data for Aldosterone-Producing Adenoma.

Pathways for Aldosterone-Producing Adenoma

Pathways related to Aldosterone-Producing Adenoma according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.36 CACNA1D ATP2B3 ATP1A1
2
Show member pathways
11.99 KCNJ5 CACNA1D ATP2B3
3
Show member pathways
11.87 KCNJ5 CYP21A2 CYP11B2 CACNA1D ATP2B3 ATP1A1
4 11.66 CACNA1D ATP2B3 ATP1A1
5
Show member pathways
11.62 CACNA1D ATP1A1
6 11.57 KCNJ5 CACNA1D
7 11.5 ATP2B3 ATP1A1
8
Show member pathways
11.42 CYP21A2 CYP11B2
9 11.37 CACNA1D ATP1A1
10
Show member pathways
11.22 CYP21A2 CYP11B2
11 11.01 CACNA1D ATP1A1
12 10.88 KCNJ5 CACNA1D ATP1A1
13
Show member pathways
10.58 CYP21A2 CYP11B2

GO Terms for Aldosterone-Producing Adenoma

Cellular components related to Aldosterone-Producing Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular vesicle GO:1903561 8.96 ATP2B3 ATP1A1
2 T-tubule GO:0030315 8.62 KCNJ5 ATP1A1

Biological processes related to Aldosterone-Producing Adenoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.56 KCNJ5 CACNA1D ATP2B3 ATP1A1
2 calcium ion transport GO:0006816 9.51 CACNA1D ATP2B3
3 potassium ion transport GO:0006813 9.49 KCNJ5 ATP1A1
4 calcium ion transmembrane transport GO:0070588 9.48 CACNA1D ATP2B3
5 steroid metabolic process GO:0008202 9.46 CYP21A2 CYP11B2
6 steroid biosynthetic process GO:0006694 9.43 CYP21A2 CYP11B2
7 potassium ion import across plasma membrane GO:1990573 9.4 KCNJ5 ATP1A1
8 regulation of heart rate by cardiac conduction GO:0086091 9.37 KCNJ5 CACNA1D
9 sterol metabolic process GO:0016125 9.32 CYP21A2 CYP11B2
10 cardiac muscle cell action potential involved in contraction GO:0086002 9.16 CACNA1D ATP1A1
11 glucocorticoid biosynthetic process GO:0006704 8.96 CYP21A2 CYP11B2
12 mineralocorticoid biosynthetic process GO:0006705 8.62 CYP21A2 CYP11B2

Molecular functions related to Aldosterone-Producing Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 9.65 CYP21A2 CYP11B2 CACNA1D ATP2B3 ATP1A1
2 iron ion binding GO:0005506 9.4 CYP21A2 CYP11B2
3 heme binding GO:0020037 9.37 CYP21A2 CYP11B2
4 voltage-gated ion channel activity GO:0005244 9.32 KCNJ5 CACNA1D
5 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.16 CYP21A2 CYP11B2
6 steroid hydroxylase activity GO:0008395 8.96 CYP21A2 CYP11B2
7 ankyrin binding GO:0030506 8.62 CACNA1D ATP1A1

Sources for Aldosterone-Producing Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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