MCID: ALD013
MIFTS: 38

Aldosterone-Producing Adenoma

Categories: Blood diseases, Endocrine diseases

Aliases & Classifications for Aldosterone-Producing Adenoma

MalaCards integrated aliases for Aldosterone-Producing Adenoma:

Name: Aldosterone-Producing Adenoma 25 17
Conn Adenoma 25 71
Primary Aldosteronism Due to Conn Adenoma 25
Aldosterone-Secreting Adenoma 25
Aldosteronoma 25

Classifications:



External Ids:

UMLS 71 C0009777

Summaries for Aldosterone-Producing Adenoma

Genetics Home Reference : 25 An aldosterone-producing adenoma is a noncancerous (benign) tumor that develops in an adrenal gland, which is a small hormone-producing gland located on top of each kidney. In most cases, individuals develop a single tumor in one of the adrenal glands. The adrenal tumor produces too much of the hormone aldosterone, which is a condition known as primary hyperaldosteronism. Aldosterone helps regulate the body's fluid levels and blood pressure by controlling the amount of salt retained by the kidneys. Excess aldosterone causes the kidneys to retain more salt than normal, which increases the body's fluid levels and blood pressure. People with an aldosterone-producing adenoma may develop severe high blood pressure (hypertension), and they have an increased risk of heart attack, stroke, or an irregular heart beat (atrial fibrillation).

MalaCards based summary : Aldosterone-Producing Adenoma, also known as conn adenoma, is related to hypokalemia and familial hyperaldosteronism. An important gene associated with Aldosterone-Producing Adenoma is KCNJ5 (Potassium Inwardly Rectifying Channel Subfamily J Member 5), and among its related pathways/superpathways are Cardiac conduction and cGMP-PKG signaling pathway. The drugs Dopamine and Bromocriptine have been mentioned in the context of this disorder. Affiliated tissues include heart, adrenal gland and kidney.

Wikipedia : 74 Primary aldosteronism, also known as primary hyperaldosteronism or Conn's syndrome, refers to the excess... more...

Related Diseases for Aldosterone-Producing Adenoma

Diseases related to Aldosterone-Producing Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 hypokalemia 30.8 KCNJ5 CACNA1D
2 familial hyperaldosteronism 30.5 KCNJ5 CYP11B2
3 conn's syndrome 30.2 KCNJ5 CYP21A2 CYP11B2 CACNA1D ATP2B3 ATP1A1
4 adrenal cortical carcinoma 30.0 KCNJ5 CYP21A2 CYP11B2
5 adenoma 30.0 KCNJ5 CYP21A2 CYP11B2 ATP2B3 ATP1A1
6 adrenal adenoma 29.6 KCNJ5 CYP21A2 CYP11B2 ATP2B3
7 hyperaldosteronism, familial, type i 29.1 KCNJ5 CYP11B2 CACNA1D ATP1A1
8 hypertension, essential 28.8 KCNJ5 CYP11B2 CACNA1D ATP2B3 ATP1A1
9 adrenal carcinoma 28.6 KCNJ5 CYP21A2 CYP11B2 ATP2B3
10 hyperaldosteronism, familial, type ii 11.5
11 adrenal cortical adenoma 10.5
12 pheochromocytoma 10.5
13 adrenal gland pheochromocytoma 10.5
14 adrenocortical carcinoma, hereditary 10.3
15 adrenal cortical adenocarcinoma 10.3
16 malignant hypertension 10.3
17 kidney cancer 10.3
18 adrenal hyperplasia, congenital, due to 3-beta-hydroxysteroid dehydrogenase 2 deficiency 10.2
19 acth-independent macronodular adrenal hyperplasia 10.2
20 hyperparathyroidism 10.2
21 congestive heart failure 10.2
22 amenorrhea 10.1
23 pure autonomic failure 10.0
24 hypoxia 10.0
25 diabetes mellitus, noninsulin-dependent 10.0
26 fibrosis of extraocular muscles, congenital, 1 10.0
27 neurofibromatosis, type iv, of riccardi 10.0
28 hypokalemic periodic paralysis, type 1 10.0
29 liddle syndrome 1 10.0
30 retinoblastoma 10.0
31 apparent mineralocorticoid excess 10.0
32 46,xy sex reversal 2 10.0
33 pituitary adenoma, prolactin-secreting 10.0
34 hyperaldosteronism, familial, type iii 10.0
35 primary aldosteronism, seizures, and neurologic abnormalities 10.0
36 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 10.0
37 familial adenomatous polyposis 10.0
38 pre-eclampsia 10.0
39 glucose intolerance 10.0
40 portal hypertension 10.0
41 primary hyperparathyroidism 10.0
42 heart disease 10.0
43 hepatic coma 10.0
44 hepatic encephalopathy 10.0
45 renovascular hypertension 10.0
46 pneumothorax 10.0
47 glomerulonephritis 10.0
48 anuria 10.0
49 neurilemmoma 10.0
50 teratocarcinoma 10.0

Graphical network of the top 20 diseases related to Aldosterone-Producing Adenoma:



Diseases related to Aldosterone-Producing Adenoma

Symptoms & Phenotypes for Aldosterone-Producing Adenoma

Drugs & Therapeutics for Aldosterone-Producing Adenoma

Drugs for Aldosterone-Producing Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 85)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
2
Bromocriptine Approved, Investigational Phase 4 25614-03-3 31101
3
Zinc Approved, Investigational Phase 4 7440-66-6 32051
4
Nitric Oxide Approved Phase 4 10102-43-9 145068
5 Dopamine Agents Phase 4
6 Antiparkinson Agents Phase 4
7 Dopamine agonists Phase 4
8 Protective Agents Phase 4
9 Vasodilator Agents Phase 4
10 Hypoglycemic Agents Phase 4
11 Antioxidants Phase 4
12 Free Radical Scavengers Phase 4
13 Pharmaceutical Solutions Phase 4
14 Insulin, Globin Zinc Phase 4
15 insulin Phase 4
16 Kava Approved, Investigational, Nutraceutical Phase 3 9000-38-8
17 Mineralocorticoids Phase 3
18 Mineralocorticoid Receptor Antagonists Phase 3
19 Melanocyte-Stimulating Hormones Phase 3
20 beta-endorphin Phase 3
21 Adrenocorticotropic Hormone Phase 3
22
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
23
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
24
Everolimus Approved Phase 2 159351-69-6 6442177 70789204
25
Amlodipine Approved Phase 2 88150-42-9 2162
26
Calcium Approved, Nutraceutical Phase 2 7440-70-2 271
27 Anti-Infective Agents Phase 2
28 Anti-Bacterial Agents Phase 2
29 Antibiotics, Antitubercular Phase 2
30 Antifungal Agents Phase 2
31 Immunosuppressive Agents Phase 2
32 Immunologic Factors Phase 2
33 Antihypertensive Agents Phase 2
34 Hormones Phase 2
35 calcium channel blockers Phase 2
36 Calcium, Dietary Phase 2
37
Eplerenone Approved 107724-20-9 150310 443872
38
Spironolactone Approved 1952-01-7, 52-01-7 5833
39
Captopril Approved 62571-86-2 44093
40
Etomidate Approved 33125-97-2 36339 667484
41
Angiotensin II Approved, Investigational 68521-88-0, 4474-91-3, 11128-99-7 172198
42
Olmesartan Approved, Investigational 144689-24-7, 144689-63-4 158781 130881
43
Epinephrine Approved, Vet_approved 51-43-4 5816
44
Racepinephrine Approved 329-65-7 838
45
Clarithromycin Approved 81103-11-9 84029
46
Hydrocortisone acetate Approved, Vet_approved 50-03-3
47
Hydrocortisone Approved, Vet_approved 50-23-7 5754
48
Canrenone Investigational 976-71-6 13789
49
protease inhibitors
50 HIV Protease Inhibitors

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 The Therapeutic Effect of Bromocriptin in Patients With Primary Aldosteronism Unknown status NCT00451672 Phase 4 bromocriptine
2 The Role of Aldosterone on Sympathetic Nerve Activity and Insulin Sensitivity Recruiting NCT02102243 Phase 4 DEFINITY® infusion;Human Recombinant Regular Insulin infusion;Dextrose infusion
3 Towards Cost-effective Management of Patients With Hypertension Due to Primary Aldosteronism: Adrenal Vein Sampling or Ct-scan? Completed NCT01096654 Phase 3
4 Open-label Study on Treatment of Primary Aldosteronism With Everolimus Completed NCT03174171 Phase 2 Everolimus 0.75 mg
5 Calcium Channel Blockade in Primary Aldosteronism Not yet recruiting NCT04179019 Phase 2 Amlodipine
6 Expression of D2-Like Dopamine Receptor of Human Aldosterone-Producing Adenoma and Its Role in Regulation of Aldosterone Secretion and Cell Proliferation Unknown status NCT00173446
7 Laparoscopic Adrenalectomy Versus Radiofrequency Ablation for Aldosterone-producing Adenoma: a Prospective Randomized Controlled Trial Unknown status NCT02030587
8 Aldosterone-Renin Ratio to Diagnose Primary Aldosteronism in a Population of Patients With Therapy-Resistant Hypertension: Test Characteristics, Diagnostic Value and Predictive Value for Antihypertensive Treatment. The Dutch ARRAT Study. Unknown status NCT00407784 eplerenone
9 Postoperative Cardiovascular Index Change of Primary Aldosteronism Unknown status NCT00746070
10 Diagnosis of Primary Aldosteronism: Comparison of Post Captopril Active Renin Concentration and Plasma Renin Activity Unknown status NCT00917345 captopril test
11 Arterial Stiffness Index as a Predictor of Surgically Correctable Primary Aldosteronism Completed NCT01190501
12 Functional Imaging With 11C-Metomidate Positron Emission Tomography Versus Adrenal Vein Sampling in Differential Diagnosis of Unilateral and Bilateral Aldosterone Secretion in Primary Aldosteronism Completed NCT01567111
13 Intraoperative Analysis of Cortisol During Adrenal Vein Catheterization and Sampling in Patients With Primary Hyperaldosteronism. Completed NCT01761344
14 Primary Aldosteronism in General Practice: Organ Damage, Epidemiology and Treatment Completed NCT01728493
15 Radiofrequency Ablation for Aldosterone-producting Adenoma in Patients With Primary Aldosteronism: Evaluation of the Blood Pressure Control and of Its Safety. Completed NCT02756754
16 Prospective Assessment of The Prevalence of Primary Aldosteronism in Hypertensive Patients Presenting With Atrial Flutter or Fibrillation Completed NCT01267747
17 Effects of Mineralocorticoid and AT-1 Receptor Antagonism on the Aldosterone-Renin Ratio (ARR) In Primary Aldosteronism Patients (EMIRA Study): Rationale and Design Completed NCT04185857 canrenone 50-100 mg orally once a day;olmesartan 10-20 mg orally once a day
18 Multicenter Study on Use and Interpretation of Adrenal Vein Sampling Completed NCT01234220
19 Efficacy and Safety of Renal Sympathetic Denervation From The Adventitia on Hypertension in Patients With Primary Aldosteronism Recruiting NCT02642445
20 Feasibility Study of RadioFrequency Endoscopic ABlation, With ULtrasound Guidance, as a Non-surgical, Adrenal Sparing Treatment for Aldosterone-producing Adenomas Recruiting NCT03405025
21 Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks Recruiting NCT03374215
22 Macrolides for KCNJ5 - Mutated Aldosterone-Producing Adenoma (MAPA): A Study Of Personalized Diagnosis of Primary Aldosteronism With Implications For Treatment Not yet recruiting NCT03414918 Clarithromycin
23 The Intra-Procedural Cortisol Assay During Adrenal Vein Sampling: Rationale andDesign of A Randomized Study (I-PADUA) Not yet recruiting NCT03449797

Search NIH Clinical Center for Aldosterone-Producing Adenoma

Genetic Tests for Aldosterone-Producing Adenoma

Anatomical Context for Aldosterone-Producing Adenoma

MalaCards organs/tissues related to Aldosterone-Producing Adenoma:

40
Heart, Adrenal Gland, Kidney, Testes, Cortex, Adrenal Cortex, Endothelial

Publications for Aldosterone-Producing Adenoma

Articles related to Aldosterone-Producing Adenoma:

(show top 50) (show all 876)
# Title Authors PMID Year
1
Endoplasmic Reticulum Chaperone Calmegin Is Upregulated in Aldosterone-Producing Adenoma and Associates With Aldosterone Production. 61
31865789 2020
2
Surgery decreases the long-term incident stroke risk in patients with primary aldosteronism. 61
31676114 2020
3
Primary aldosteronism in a general population sample. The Czech post-MONICA study. 61
32036692 2020
4
Molecular and Electrophysiological Analyses of ATP2B4 Gene Variants in Bilateral Adrenal Hyperaldosteronism. 61
32002807 2020
5
Old and new genes in primary aldosteronism. 61
32007424 2020
6
Somatic CACNA1H Mutation As a Cause of Aldosterone-Producing Adenoma. 61
31983310 2020
7
[The Value of Postural Stimulation Test Combined with Adrenal CT in the Diagnosis of Aldosterone-producing Adenoma]. 61
31950795 2020
8
Primary aldosteronism in Klinefelter's syndrome: two cases. 61
31841437 2019
9
Aldosterone Stimulates Its Biosynthesis Via a Novel GPER-Mediated Mechanism. 61
31125081 2019
10
Molecular Mechanisms of Primary Aldosteronism. 61
31884735 2019
11
Prevalence, diagnosis and outcomes of treatment for primary aldosteronism. 61
31837980 2019
12
[Primary aldosteronism : Genetics and pathology]. 61
31705237 2019
13
CLCN2 clicks with aldosterone-producing adenomas, too! 61
31585437 2019
14
Elevated Plasma Renin Activity Caused by Accelerated-malignant Hypertension in a Patient with Aldosterone-producing Adenoma Complicated with Renal Insufficiency. 61
31292373 2019
15
Primary and Secondary Hyperparathyroidism in Patients with Primary Aldosteronism - Findings From the German Conn's Registry. 61
31698477 2019
16
Genetic causes of primary aldosteronism. 61
31695023 2019
17
Left Ventricular Dysfunction in Patients With Primary Aldosteronism: A Propensity Score-Matching Follow-Up Study With Tissue Doppler Imaging. 61
31718437 2019
18
A somatic mutation in CLCN2 identified in a sporadic aldosterone-producing adenoma. 61
31491746 2019
19
Genetic and epigenetic analyses of aldosterone-producing adenoma with hypercortisolemia. 61
31400391 2019
20
Insulin secretion and sensitivity before and after surgical treatment for aldosterone-producing adenoma. 61
31676325 2019
21
AT1AA (Angiotensin II Type-1 Receptor Autoantibodies): Cause or Consequence of Human Primary Aldosteronism? 61
31476908 2019
22
Diverse Responses of Autoantibodies to the Angiotensin II Type 1 Receptor in Primary Aldosteronism. 61
31476909 2019
23
A case report of idiopathic hyperaldosteronism characterized by bilateral adrenal adenoma. 61
31651844 2019
24
Plasma Aldosterone After Seated Saline Infusion Test Outperforms Captopril Test at Predicting Clinical Outcomes After Adrenalectomy for Primary Aldosteronism. 61
31216359 2019
25
Retinoic acid receptor α as a novel contributor to adrenal cortex structure and function through interactions with Wnt and Vegfa signalling. 61
31605007 2019
26
L- and T-type calcium channels control aldosterone production from human adrenals. 61
31652415 2019
27
Left atrial myocardial dysfunction in patients with primary aldosteronism as assessed by speckle-tracking echocardiography. 61
31157742 2019
28
Adrenal venous sampling: cosyntropin stimulation or not? 61
31176302 2019
29
Steroid Profiling and Immunohistochemistry for Subtyping and Outcome Prediction in Primary Aldosteronism-a Review. 61
31482378 2019
30
H-score of 11β-hydroxylase and aldosterone synthase in the histopathological diagnosis of adrenocortical tumors. 61
31332713 2019
31
Primary adrenal schwannoma: a series of 31 cases emphasizing their clinicopathologic features and favorable prognosis. 61
31278687 2019
32
PTH Modulation by Aldosterone and Angiotensin II is Blunted in Hyperaldosteronism and Rescued by Adrenalectomy. 61
30865228 2019
33
A clinical prediction score using age at diagnosis and saline infusion test parameters can predict aldosterone-producing adenoma from idiopathic adrenal hyperplasia. 61
31529391 2019
34
Molecular mechanisms in primary aldosteronism 61
31397984 2019
35
THE POTENTIAL CLINICAL APPLICATION OF A LOWER BILATERAL ADRENAL LIMB WIDTH RATIO (L/RW) IN PATIENTS WITH BILATERAL PRIMARY HYPERALDOSTERONISM. 61
31013150 2019
36
miRNA299 involvement in CYP11B2 expression in aldosterone-producing adenoma. 61
31096184 2019
37
Hypertension with primary aldosteronism is associated with increased carotid intima-media thickness and endothelial dysfunction. 61
31187936 2019
38
Adrenalectomy Improves the Long-Term Risk of End-Stage Renal Disease and Mortality of Primary Aldosteronism. 61
31086833 2019
39
18-Oxocortisol Synthesis in Aldosterone-Producing Adrenocortical Adenoma and Significance of KCNJ5 Mutation Status. 61
31006333 2019
40
Primary Hyperaldosteronism Induced by Aldosterone-Producing Adenoma Co-Existing with A Left Suprarenal Accessory Spleen: Two Case Reports and A Review of The Literature. 61
30120761 2019
41
Efficient screening of patients with aldosterone-producing adenoma using the ACTH stimulation test. 61
30622316 2019
42
A novel clinical nomogram to predict bilateral hyperaldosteronism in Chinese patients with primary aldosteronism. 61
30820995 2019
43
Computed tomography scan can be misleading in the lateralisation of aldosterone excess 61
31368677 2019
44
Hypercortisolism and primary aldosteronism caused by bilateral adrenocortical adenomas: a case report. 61
31208392 2019
45
Robot-assisted Partial Adrenalectomy for the Treatment of Conn's Syndrome: Surgical Technique, and Perioperative and Functional Outcomes. 61
30077398 2019
46
Eplerenone improves endothelial function and arterial stiffness and inhibits Rho-associated kinase activity in patients with idiopathic hyperaldosteronism: a pilot study. 61
30418321 2019
47
Risk of severe erectile dysfunction in primary hyperaldosteronism: A population-based propensity score matching cohort study. 61
30473204 2019
48
10 good reasons why adrenal vein sampling is the preferred method for referring primary aldosteronism patients for adrenalectomy. 61
30431526 2019
49
Proteomic Landscape of Aldosterone-Producing Adenoma. 61
30580688 2019
50
A Rare Aldosterone-Producing Adenoma Detected by 68Ga-pentixafor PET-CT: A Case Report and Literature Review. 61
31849839 2019

Variations for Aldosterone-Producing Adenoma

Expression for Aldosterone-Producing Adenoma

Search GEO for disease gene expression data for Aldosterone-Producing Adenoma.

Pathways for Aldosterone-Producing Adenoma

Pathways related to Aldosterone-Producing Adenoma according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.43 CACNA1D ATP2B3 ATP1A1
2
Show member pathways
12.04 CACNA1D ATP2B3 ATP1A1
3
Show member pathways
11.99 KCNJ5 CACNA1D ATP2B3
4
Show member pathways
11.87 KCNJ5 CYP21A2 CYP11B2 CACNA1D ATP2B3 ATP1A1
5 11.77 CACNA1D ATP2B3 ATP1A1
6
Show member pathways
11.66 CACNA1D ATP1A1
7 11.62 KCNJ5 CACNA1D
8 11.56 ATP2B3 ATP1A1
9
Show member pathways
11.48 CYP21A2 CYP11B2
10 11.44 CACNA1D ATP1A1
11
Show member pathways
11.31 CYP21A2 CYP11B2
12 11.28 KCNJ5 CACNA1D
13 11.22 ATP2B3 ATP1A1
14 11.16 ATP2B3 ATP1A1
15 11.08 CACNA1D ATP1A1
16 10.88 KCNJ5 CACNA1D ATP1A1
17
Show member pathways
10.5 CYP21A2 CYP11B2

GO Terms for Aldosterone-Producing Adenoma

Cellular components related to Aldosterone-Producing Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular vesicle GO:1903561 8.96 ATP2B3 ATP1A1
2 T-tubule GO:0030315 8.62 KCNJ5 ATP1A1

Biological processes related to Aldosterone-Producing Adenoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.56 KCNJ5 CACNA1D ATP2B3 ATP1A1
2 ion transmembrane transport GO:0034220 9.54 CACNA1D ATP2B3 ATP1A1
3 calcium ion transmembrane transport GO:0070588 9.51 CACNA1D ATP2B3
4 steroid metabolic process GO:0008202 9.49 CYP21A2 CYP11B2
5 steroid biosynthetic process GO:0006694 9.48 CYP21A2 CYP11B2
6 regulation of cardiac conduction GO:1903779 9.46 ATP2B3 ATP1A1
7 potassium ion import across plasma membrane GO:1990573 9.43 KCNJ5 ATP1A1
8 regulation of heart rate by cardiac conduction GO:0086091 9.4 KCNJ5 CACNA1D
9 sterol metabolic process GO:0016125 9.32 CYP21A2 CYP11B2
10 cardiac muscle cell action potential involved in contraction GO:0086002 9.16 CACNA1D ATP1A1
11 glucocorticoid biosynthetic process GO:0006704 8.96 CYP21A2 CYP11B2
12 mineralocorticoid biosynthetic process GO:0006705 8.62 CYP21A2 CYP11B2

Molecular functions related to Aldosterone-Producing Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 9.72 CYP21A2 CYP11B2 CACNA1D ATP2B3 ATP1A1
2 voltage-gated ion channel activity GO:0005244 9.26 KCNJ5 CACNA1D
3 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.16 CYP21A2 CYP11B2
4 steroid hydroxylase activity GO:0008395 8.96 CYP21A2 CYP11B2
5 ankyrin binding GO:0030506 8.62 CACNA1D ATP1A1

Sources for Aldosterone-Producing Adenoma

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17 EFO
18 ExPASy
19 FMA
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29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
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43 MeSH
44 MESH via Orphanet
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57 OMIM via Orphanet
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