MCID: ALK003
MIFTS: 32

Aleukemic Leukemia Cutis

Categories: Blood diseases, Cancer diseases

Aliases & Classifications for Aleukemic Leukemia Cutis

MalaCards integrated aliases for Aleukemic Leukemia Cutis:

Name: Aleukemic Leukemia Cutis 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:6003
NCIt 51 C4983
UMLS 74 C0887846

Summaries for Aleukemic Leukemia Cutis

MalaCards based summary : Aleukemic Leukemia Cutis is related to acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) and myeloid leukemia. An important gene associated with Aleukemic Leukemia Cutis is NPM1 (Nucleophosmin 1), and among its related pathways/superpathways are NF-kappaB Signaling and Transcriptional misregulation in cancer. Affiliated tissues include monocytes, b cells and myeloid, and related phenotypes are hematopoietic system and immune system

Related Diseases for Aleukemic Leukemia Cutis

Diseases related to Aleukemic Leukemia Cutis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Related Disease Score Top Affiliating Genes
1 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 30.5 FLT3 MPO MYH11
2 myeloid leukemia 30.1 CD33 FLT3 MYH11 NPM1 RARA
3 myelodysplastic syndrome 29.4 ANPEP CD33 CD34 FLT3 NPM1
4 acute promyelocytic leukemia 27.8 ANPEP CD33 CD34 ELANE FLT3 FUT4
5 leukemia, acute myeloid 27.7 ANPEP CD33 CD34 CD7 FLT3 FUT4
6 subleukemic leukemia 11.9
7 leukemia 10.8
8 leukemia, acute lymphoblastic 10.5
9 lymphocytic leukemia 10.5
10 mast-cell sarcoma 10.4 ANPEP MPO
11 acute myeloblastic leukemia without maturation 10.4 FLT3 NPM1
12 acute myeloblastic leukemia with maturation 10.4 FLT3 NPM1
13 cytogenetically normal acute myeloid leukemia 10.3 FLT3 NPM1
14 acute myeloid leukemia with minimal differentiation 10.3 FLT3 MPO
15 natural killer cell leukemia 10.3 MPO NCAM1
16 myelophthisic anemia 10.3 ANPEP CD33
17 cerebral aneurysms 10.3 ELANE MPO
18 pasteurellosis 10.3 ELANE MPO
19 mediastinal cancer 10.3 CD33 NCAM1
20 rapidly progressive glomerulonephritis 10.3 ELANE MPO
21 leukemia, acute monocytic 10.3
22 monocytic leukemia 10.3
23 bronchopneumonia 10.3 ELANE MPO
24 vulvitis 10.3 ELANE MPO
25 periodontosis 10.2 ELANE MPO
26 parasitic ichthyosporea infectious disease 10.2 CD68 NCAM1
27 rhinosporidiosis 10.2 CD68 NCAM1
28 anterior scleritis 10.2 MPO NCAM1
29 pericoronitis 10.2 CD68 NCAM1
30 granulomatous myositis 10.2 CD68 NCAM1
31 leukemia, acute lymphoblastic 3 10.2 ANPEP FLT3 MPO
32 blastic plasmacytoid dendritic cell 10.2 NCAM1 NPM1
33 lymphatic system cancer 10.1 NCAM1 NPM1 SPN
34 carbuncle 10.1 MPO SPN
35 ulcerative stomatitis 10.1 CD68 MPO
36 clear cell acanthoma 10.1 CD68 HAVCR1
37 mastocytosis 10.1
38 acute t cell leukemia 10.1
39 dendritic cell tumor 10.1 CD68 MPO
40 helsmoortel-van der aa syndrome 10.1 CD33 CD7 NCAM1
41 lung meningioma 10.1 CD34 NCAM1
42 chronic monocytic leukemia 10.0 CD34 MPO
43 granulomatous gastritis 10.0 CD68 FUT4
44 conventional angiosarcoma 10.0 CD34 NCAM1
45 hodgkin's lymphoma, lymphocytic depletion 10.0 CD68 FUT4
46 angiomyoma 10.0 CD34 NCAM1
47 rhinoscleroma 10.0 CD68 NCAM1 SPN
48 interstitial emphysema 10.0 CD34 ELANE
49 glomeruloid hemangioma 9.9 CD34 CD68
50 hemangioma of liver 9.9 CD34 CD68

Graphical network of the top 20 diseases related to Aleukemic Leukemia Cutis:



Diseases related to Aleukemic Leukemia Cutis

Symptoms & Phenotypes for Aleukemic Leukemia Cutis

MGI Mouse Phenotypes related to Aleukemic Leukemia Cutis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.9 ANPEP CD34 CD68 CD7 ELANE FLT3
2 immune system MP:0005387 9.7 ANPEP CD34 CD68 CD7 ELANE FLT3
3 neoplasm MP:0002006 9.1 CD34 ELANE FLT3 NPM1 RARA SPN

Drugs & Therapeutics for Aleukemic Leukemia Cutis

Search Clinical Trials , NIH Clinical Center for Aleukemic Leukemia Cutis

Genetic Tests for Aleukemic Leukemia Cutis

Anatomical Context for Aleukemic Leukemia Cutis

MalaCards organs/tissues related to Aleukemic Leukemia Cutis:

42
Monocytes, B Cells, Myeloid, Bone, T Cells

Publications for Aleukemic Leukemia Cutis

Articles related to Aleukemic Leukemia Cutis:

(show all 27)
# Title Authors Year
1
Aleukemic leukemia cutis. ( 30742583 )
2019
2
Aleukemic Leukemia Cutis Presenting as a Sole Sign of Relapsed Paediatric Acute Lymphoblastic Leukemia. ( 27408353 )
2016
3
Pediatric Aleukemic Leukemia Cutis: Report of 3 Cases and Review of the Literature. ( 25148106 )
2014
4
Aleukemic leukemia cutis: an unusual rash in a child. ( 25035690 )
2014
5
Acute myeloid leukemia 7A years after aleukemic leukemia cutis. ( 24261792 )
2013
6
Recurrent aleukemic leukemia cutis in a patient with pre-B-cell acute lymphoblastic leukemia. ( 23733764 )
2013
7
Acute promyelocytic leukemia following aleukemic leukemia cutis harboring NPM/RARA fusion gene. ( 22573339 )
2012
8
Aleukemic leukemia cutis in a child preceding T-cell acute lymphoblastic leukemia. ( 21895759 )
2011
9
Aleukemic leukemia cutis manifesting with disseminated nodular eruptions and a plaque preceding acute monocytic leukemia: a case report. ( 22187541 )
2011
10
Siblings presenting with progressive congenital aleukemic leukemia cutis. ( 21425444 )
2011
11
Aleukemic leukemia cutis with extensive bone involvement. ( 20708479 )
2010
12
Spontaneous regression of aleukemic leukemia cutis harboring a NPM/RARA fusion gene in an infant with cutaneous mastocytosis. ( 19052694 )
2009
13
Aleukemic leukemia cutis preceding acute monocytic leukemia: a case report. ( 18782972 )
2008
14
Aleukemic leukemia cutis. ( 17456918 )
2007
15
Aleukemic leukemia cutis in a patient with Philadelphia chromosome-positive biphenotypic leukemia. ( 15540904 )
2004
16
Guess what. B-cell acute lymphoblastic leukemia with aleukemic leukemia cutis. ( 11275816 )
2001
17
Aleukemic leukemia cutis presenting as benign-appearing exanthema. ( 11411915 )
2001
18
Monocytic aleukemic leukemia cutis. ( 10565632 )
1999
19
Aleukemic leukemia cutis in an adolescent boy. ( 10084909 )
1999
20
Aleukemic leukemia cutis in a patient with acute lymphoblastic leukemia. ( 9555803 )
1998
21
Aleukemic leukemia cutis preceding overt acute myeloid leukemia in myelodysplastic syndrome. ( 8980276 )
1997
22
Lymphocytic aleukemic leukemia cutis. ( 8912603 )
1996
23
Aleukemic leukemia cutis. ( 2406302 )
1990
24
Aleukemic leukemia cutis. An unusual presentation of acute myelomonocytic leukemia. ( 2943614 )
1986
25
Aleukemic leukemia cutis. ( 3729513 )
1986
26
Aleukemic leukemia cutis: juvenile chronic granulocytic leukemia presenting with figurate cutaneous lesions. ( 6579062 )
1983
27
Aleukemic leukemia cutis. ( 1062968 )
1976

Variations for Aleukemic Leukemia Cutis

Expression for Aleukemic Leukemia Cutis

Search GEO for disease gene expression data for Aleukemic Leukemia Cutis.

Pathways for Aleukemic Leukemia Cutis

GO Terms for Aleukemic Leukemia Cutis

Cellular components related to Aleukemic Leukemia Cutis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.26 ANPEP CD33 CD34 NCAM1
2 cell surface GO:0009986 9.1 CD34 ELANE FUT4 NCAM1 RARA SPN

Biological processes related to Aleukemic Leukemia Cutis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 leukocyte migration GO:0050900 9.58 CD34 ELANE SPN
2 neutrophil degranulation GO:0043312 9.55 ANPEP CD33 CD68 ELANE MPO
3 viral entry into host cell GO:0046718 9.43 ANPEP HAVCR1 NCAM1
4 defense response to fungus GO:0050832 9.37 ELANE MPO
5 viral process GO:0016032 9.35 ANPEP FLT3 HAVCR1 NCAM1 NPM1
6 negative regulation of growth of symbiont in host GO:0044130 9.32 ELANE MPO
7 response to yeast GO:0001878 8.62 ELANE MPO

Molecular functions related to Aleukemic Leukemia Cutis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 9.13 ANPEP HAVCR1 NCAM1
2 signaling receptor activity GO:0038023 8.92 ANPEP CD33 CD7 RARA

Sources for Aleukemic Leukemia Cutis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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