MCID: ALK003
MIFTS: 33

Aleukemic Leukemia Cutis

Categories: Cancer diseases, Immune diseases, Blood diseases

Aliases & Classifications for Aleukemic Leukemia Cutis

MalaCards integrated aliases for Aleukemic Leukemia Cutis:

Name: Aleukemic Leukemia Cutis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:6003
NCIt 50 C4983
UMLS 73 C0887846

Summaries for Aleukemic Leukemia Cutis

MalaCards based summary : Aleukemic Leukemia Cutis is related to leukemia and acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22). An important gene associated with Aleukemic Leukemia Cutis is NPM1 (Nucleophosmin 1), and among its related pathways/superpathways are NF-kappaB Signaling and Transcriptional misregulation in cancer. Affiliated tissues include monocytes, myeloid and b cells, and related phenotypes are hematopoietic system and cardiovascular system

Related Diseases for Aleukemic Leukemia Cutis

Diseases related to Aleukemic Leukemia Cutis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Related Disease Score Top Affiliating Genes
1 leukemia 30.5 FLT3 NPM1 RARA RUNX1
2 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 30.2 FLT3 MPO MYH11 RUNX1
3 myeloid leukemia 29.2 CD33 FLT3 MYH11 NPM1 RARA RUNX1
4 myelodysplastic syndrome 28.1 ANPEP CD33 CD34 FLT3 NPM1 RUNX1
5 acute promyelocytic leukemia 24.9 ANPEP CD33 CD34 ELANE FLT3 FUT4
6 leukemia, acute myeloid 24.4 ANPEP CD33 CD34 CD7 FLT3 FUT4
7 subleukemic leukemia 11.8
8 mast-cell sarcoma 10.8 ANPEP MPO
9 acute myeloblastic leukemia without maturation 10.8 FLT3 NPM1
10 tetrasomy 21 10.8 ANPEP RUNX1
11 acute myeloblastic leukemia with maturation 10.7 FLT3 NPM1
12 cerebral aneurysms 10.7 ELANE MPO
13 acute myeloid leukemia with minimal differentiation 10.7 FLT3 MPO
14 cytogenetically normal acute myeloid leukemia 10.7 FLT3 NPM1
15 pasteurellosis 10.7 ELANE MPO
16 dermis tumor 10.6 HAVCR1 LYZ
17 acute myeloid leukemia with t(8;21)(q22;q22) translocation 10.6 FLT3 RUNX1
18 mediastinal cancer 10.5 ANPEP CD33 NCAM1
19 multiple cranial nerve palsy 10.5 MPO NCAM1 RUNX1
20 rapidly progressive glomerulonephritis 10.4 ELANE MPO
21 central nervous system sarcoma 10.4 CD68 LYZ
22 parasitic ichthyosporea infectious disease 10.4 CD68 NCAM1
23 malignant giant cell tumor of soft parts 10.4 CD68 LYZ
24 rhinosporidiosis 10.4 CD68 NCAM1
25 pericoronitis 10.3 CD68 NCAM1
26 acute proliferative glomerulonephritis 10.3 LYZ MPO
27 leukemia, acute lymphoblastic 10.3
28 lymphoblastic leukemia 10.3
29 bronchopneumonia 10.3 ELANE MPO
30 liver sarcoma 10.3 CD68 LYZ
31 carbuncle 10.2 LYZ MPO SPN
32 lung meningioma 10.1 CD34 NCAM1
33 granulomatous myositis 10.1 CD68 LYZ NCAM1
34 ulcerative stomatitis 10.1 CD68 LYZ MPO
35 leukemia, acute monocytic 10.1
36 monocytic leukemia 10.1
37 chronic monocytic leukemia 10.1 CD34 MPO
38 leukemia, acute lymphoblastic 3 10.1 ANPEP FLT3 MPO RUNX1
39 conventional angiosarcoma 10.0 CD34 NCAM1
40 granulomatous gastritis 10.0 CD68 FUT4
41 rhinoscleroma 10.0 CD68 NCAM1 SPN
42 hodgkin's lymphoma, lymphocytic depletion 10.0 CD68 FUT4
43 cutaneous mastocytosis 10.0
44 acute t cell leukemia 10.0
45 vulvitis 9.9 ELANE MPO
46 myeloid sarcoma 9.9 ANPEP FLT3 MPO NCAM1 NPM1
47 angiomyoma 9.9 CD34 NCAM1
48 interstitial emphysema 9.8 CD34 ELANE
49 glomeruloid hemangioma 9.8 CD34 CD68
50 diffuse meningeal melanocytosis 9.8 CD34 CD68

Graphical network of the top 20 diseases related to Aleukemic Leukemia Cutis:



Diseases related to Aleukemic Leukemia Cutis

Symptoms & Phenotypes for Aleukemic Leukemia Cutis

MGI Mouse Phenotypes related to Aleukemic Leukemia Cutis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 MPO NPM1 ANPEP RARA CD34 CD68
2 cardiovascular system MP:0005385 9.86 LYZ MPO MYH11 NPM1 ANPEP RARA
3 immune system MP:0005387 9.77 MPO NPM1 ANPEP RARA CD34 CD68
4 neoplasm MP:0002006 9.23 NPM1 RARA CD34 RUNX1 ELANE SPN

Drugs & Therapeutics for Aleukemic Leukemia Cutis

Search Clinical Trials , NIH Clinical Center for Aleukemic Leukemia Cutis

Genetic Tests for Aleukemic Leukemia Cutis

Anatomical Context for Aleukemic Leukemia Cutis

MalaCards organs/tissues related to Aleukemic Leukemia Cutis:

41
Monocytes, Myeloid, B Cells, Bone, T Cells

Publications for Aleukemic Leukemia Cutis

Articles related to Aleukemic Leukemia Cutis:

(show all 26)
# Title Authors Year
1
Aleukemic Leukemia Cutis Presenting as a Sole Sign of Relapsed Paediatric Acute Lymphoblastic Leukemia. ( 27408353 )
2016
2
Pediatric Aleukemic Leukemia Cutis: Report of 3 Cases and Review of the Literature. ( 25148106 )
2014
3
Aleukemic leukemia cutis: an unusual rash in a child. ( 25035690 )
2014
4
Acute myeloid leukemia 7A years after aleukemic leukemia cutis. ( 24261792 )
2013
5
Recurrent aleukemic leukemia cutis in a patient with pre-B-cell acute lymphoblastic leukemia. ( 23733764 )
2013
6
Acute promyelocytic leukemia following aleukemic leukemia cutis harboring NPM/RARA fusion gene. ( 22573339 )
2012
7
Aleukemic leukemia cutis in a child preceding T-cell acute lymphoblastic leukemia. ( 21895759 )
2011
8
Aleukemic leukemia cutis manifesting with disseminated nodular eruptions and a plaque preceding acute monocytic leukemia: a case report. ( 22187541 )
2011
9
Siblings presenting with progressive congenital aleukemic leukemia cutis. ( 21425444 )
2011
10
Aleukemic leukemia cutis with extensive bone involvement. ( 20708479 )
2010
11
Spontaneous regression of aleukemic leukemia cutis harboring a NPM/RARA fusion gene in an infant with cutaneous mastocytosis. ( 19052694 )
2009
12
Aleukemic leukemia cutis preceding acute monocytic leukemia: a case report. ( 18782972 )
2008
13
Aleukemic leukemia cutis. ( 17456918 )
2007
14
Aleukemic leukemia cutis in a patient with Philadelphia chromosome-positive biphenotypic leukemia. ( 15540904 )
2004
15
Guess what. B-cell acute lymphoblastic leukemia with aleukemic leukemia cutis. ( 11275816 )
2001
16
Aleukemic leukemia cutis presenting as benign-appearing exanthema. ( 11411915 )
2001
17
Monocytic aleukemic leukemia cutis. ( 10565632 )
1999
18
Aleukemic leukemia cutis in an adolescent boy. ( 10084909 )
1999
19
Aleukemic leukemia cutis in a patient with acute lymphoblastic leukemia. ( 9555803 )
1998
20
Aleukemic leukemia cutis preceding overt acute myeloid leukemia in myelodysplastic syndrome. ( 8980276 )
1997
21
Lymphocytic aleukemic leukemia cutis. ( 8912603 )
1996
22
Aleukemic leukemia cutis. ( 2406302 )
1990
23
Aleukemic leukemia cutis. An unusual presentation of acute myelomonocytic leukemia. ( 2943614 )
1986
24
Aleukemic leukemia cutis. ( 3729513 )
1986
25
Aleukemic leukemia cutis: juvenile chronic granulocytic leukemia presenting with figurate cutaneous lesions. ( 6579062 )
1983
26
Aleukemic leukemia cutis. ( 1062968 )
1976

Variations for Aleukemic Leukemia Cutis

Expression for Aleukemic Leukemia Cutis

Search GEO for disease gene expression data for Aleukemic Leukemia Cutis.

Pathways for Aleukemic Leukemia Cutis

GO Terms for Aleukemic Leukemia Cutis

Cellular components related to Aleukemic Leukemia Cutis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.61 ANPEP CD33 CD7 ELANE LYZ MPO
2 external side of plasma membrane GO:0009897 9.56 ANPEP CD33 CD34 NCAM1
3 azurophil granule lumen GO:0035578 9.33 ELANE LYZ MPO
4 cell surface GO:0009986 9.1 CD34 ELANE FUT4 NCAM1 RARA SPN

Biological processes related to Aleukemic Leukemia Cutis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral entry into host cell GO:0046718 9.5 ANPEP HAVCR1 NCAM1
2 defense response to bacterium GO:0042742 9.46 ELANE LYZ MPO SPN
3 hemopoiesis GO:0030097 9.43 CD34 FLT3 RUNX1
4 negative regulation of growth of symbiont in host GO:0044130 9.4 ELANE MPO
5 hematopoietic stem cell proliferation GO:0071425 9.37 CD34 RUNX1
6 neutrophil degranulation GO:0043312 9.1 ANPEP CD33 CD68 ELANE LYZ MPO
7 response to yeast GO:0001878 8.96 ELANE MPO

Molecular functions related to Aleukemic Leukemia Cutis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 8.8 ANPEP HAVCR1 NCAM1

Sources for Aleukemic Leukemia Cutis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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