MCID: ALK003
MIFTS: 26

Aleukemic Leukemia Cutis

Categories: Blood diseases, Cancer diseases

Aliases & Classifications for Aleukemic Leukemia Cutis

MalaCards integrated aliases for Aleukemic Leukemia Cutis:

Name: Aleukemic Leukemia Cutis 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:6003
NCIt 49 C4983
UMLS 71 C0887846

Summaries for Aleukemic Leukemia Cutis

Disease Ontology : 12 An aleukemic leukemia that is characterized by the infiltration of the skin and subcutaneous tissue by leukemic cells without evidence of leukemia in the bone marrow and peripheral blood.

MalaCards based summary : Aleukemic Leukemia Cutis is related to monocytic leukemia and leukemia, acute monocytic. An important gene associated with Aleukemic Leukemia Cutis is MPO (Myeloperoxidase), and among its related pathways/superpathways are Hematopoietic cell lineage and Hematopoietic Stem Cells and Lineage-specific Markers. Affiliated tissues include skin, bone and bone marrow, and related phenotypes are hematopoietic system and immune system

Related Diseases for Aleukemic Leukemia Cutis

Diseases related to Aleukemic Leukemia Cutis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
# Related Disease Score Top Affiliating Genes
1 monocytic leukemia 30.6 RARA MPO
2 leukemia, acute monocytic 30.1 RARA MPO CD33
3 leukemia, acute lymphoblastic 30.1 MPO CD33 ANPEP
4 myeloid leukemia 29.2 RARA NPM1 MPO CD33
5 myelodysplastic syndrome 28.6 NPM1 MPO CD33 ANPEP
6 acute leukemia 28.4 RARA NPM1 MPO CD33 ANPEP
7 acute promyelocytic leukemia 28.3 RARA NPM1 MPO CD33 ANPEP
8 myeloid sarcoma 28.3 SPN NPM1 MPO CD33 ANPEP
9 leukemia, acute myeloid 28.0 SPN RARA NPM1 MPO CD33 ANPEP
10 subleukemic leukemia 12.1
11 aleukemic monocytic leukemia cutis 11.6
12 leukemia 10.9
13 acute monoblastic leukemia 10.5
14 t-cell acute lymphoblastic leukemia 10.3
15 mastocytosis, cutaneous 10.2
16 aspergillosis 10.2
17 exanthem 10.2
18 urticaria 10.2
19 systemic mastocytosis 10.2
20 mastocytosis 10.2
21 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 10.2
22 mast-cell sarcoma 10.0 MPO ANPEP
23 central nervous system leukemia 9.9 CD33 ANPEP
24 myelophthisic anemia 9.9 CD33 ANPEP
25 leukemia, acute lymphoblastic 3 9.8 MPO ANPEP
26 adult acute lymphocytic leukemia 9.8 CD33 ANPEP
27 mixed phenotype acute leukemia 9.6 MPO CD33 ANPEP
28 precursor t-cell acute lymphoblastic leukemia 9.6 MPO CD33 ANPEP
29 reticulosarcoma 9.6 NPM1 ANPEP
30 pancytopenia 9.6 MPO CD33 ANPEP
31 bone marrow cancer 9.4 NPM1 CD33
32 chronic myelomonocytic leukemia 9.3 NPM1 MPO CD33
33 hematologic cancer 9.0 RARA NPM1 CD33
34 leukemia, chronic myeloid 8.9 RARA NPM1 MPO CD33
35 leukemia, chronic lymphocytic 8.9 SPN NPM1 CD33

Graphical network of the top 20 diseases related to Aleukemic Leukemia Cutis:



Diseases related to Aleukemic Leukemia Cutis

Symptoms & Phenotypes for Aleukemic Leukemia Cutis

MGI Mouse Phenotypes related to Aleukemic Leukemia Cutis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.35 ANPEP MPO NPM1 RARA SPN
2 immune system MP:0005387 9.02 ANPEP MPO NPM1 RARA SPN

Drugs & Therapeutics for Aleukemic Leukemia Cutis

Search Clinical Trials , NIH Clinical Center for Aleukemic Leukemia Cutis

Genetic Tests for Aleukemic Leukemia Cutis

Anatomical Context for Aleukemic Leukemia Cutis

MalaCards organs/tissues related to Aleukemic Leukemia Cutis:

40
Skin, Bone, Bone Marrow, Monocytes, Myeloid, T Cells, B Cells

Publications for Aleukemic Leukemia Cutis

Articles related to Aleukemic Leukemia Cutis:

(show top 50) (show all 51)
# Title Authors PMID Year
1
Aleukemic leukemia cutis mimicking urticaria pigmentosa in a patient of T-cell acute lymphoblastic leukemia. 61
31397398 2020
2
Diagnostic challenge of aleukemic leukemia cutis preceding acute myelogenous leukemia: A case report. 61
32477560 2020
3
In reply: Aleukemic leukemia cutis. 61
31066672 2019
4
To the Editor: Aleukemic leukemia cutis. 61
31066671 2019
5
Aleukemic leukemia cutis. 61
30742583 2019
6
Ominous cutaneous presentation of acute myeloid leukemia without peripheral blood involvement upon initial presentation and relapse: case report and literature review. 61
30698150 2018
7
Myeloid Neoplasms. 61
28802501 2017
8
Aleukemic Myeloid Leukemia Cutis with a Kikuchi Disease-Like Inflammatory Pattern in Myelodysplastic Syndrome. 61
28376531 2017
9
Aleukemic Leukemia Cutis Presenting as a Sole Sign of Relapsed Paediatric Acute Lymphoblastic Leukemia. 61
27408353 2016
10
Bilateral Aleukemic Myeloid Sarcoma of the Eyelids With Indolent Course. 61
26863061 2016
11
Pediatric aleukemic leukemia cutis: report of 3 cases and review of the literature. 61
25148106 2015
12
Acute myeloid leukemia 7 years after aleukemic leukemia cutis. 61
24261792 2015
13
Sweet syndrome-like neutrophilic infiltrate as initial presentation of acute myelogenous leukemia. 61
23538898 2014
14
Aleukemic leukemia cutis: an unusual rash in a child. 61
25035690 2014
15
Recurrent aleukemic leukemia cutis in a patient with pre-B-cell acute lymphoblastic leukemia. 61
23733764 2013
16
Acute promyelocytic leukemia following aleukemic leukemia cutis harboring NPM/RARA fusion gene. 61
22573339 2012
17
Aleukemic leukemia cutis in a child preceding T-cell acute lymphoblastic leukemia. 61
21895759 2011
18
Aleukemic leukemia cutis manifesting with disseminated nodular eruptions and a plaque preceding acute monocytic leukemia: a case report. 61
22187541 2011
19
Siblings presenting with progressive congenital aleukemic leukemia cutis. 61
21425444 2011
20
Aleukemic leukemia cutis with extensive bone involvement. 61
20708479 2010
21
Spontaneous regression of aleukemic leukemia cutis harboring a NPM/RARA fusion gene in an infant with cutaneous mastocytosis. 61
19052694 2009
22
Aleukemic leukemia cutis preceding acute monocytic leukemia: a case report. 61
18782972 2008
23
Aleukemic leukemia cutis. 61
17456918 2007
24
[Recurrent spontaneous regression of aleukemic leukemia cutis in a girl with acute monocytic leukemia]. 61
16986716 2006
25
[Agranular CD4+/CD56+ haematodermic neoplasm (Precursor haematologic neoplasm)]. 61
16161251 2005
26
Aleukemic leukemia cutis in a patient with Philadelphia chromosome-positive biphenotypic leukemia. 61
15540904 2004
27
Therapy-related leukemia cutis: case study of an aggressive disorder. 61
12920571 2003
28
Chronic lower limb ulcer? No--chloroma! 61
15866842 2003
29
[Aleukemic monoblastic leukemia cutis]. 61
14576608 2003
30
Primary aleukemic myeloid leukemia cutis treated successfully with combination chemotherapy: report of a case and review of the literature. 61
12768324 2003
31
Aleukemic monocytic leukemia cutis. 61
12080951 2002
32
Guess what. B-cell acute lymphoblastic leukemia with aleukemic leukemia cutis. 61
11275816 2001
33
Aleukemic leukemia cutis presenting as benign-appearing exanthema. 61
11411915 2001
34
Monocytic aleukemic leukemia cutis. 61
10565632 1999
35
Cutaneous granulocytic sarcoma mimicking immunoblastic large cell lymphoma. 61
10365856 1999
36
Aleukemic leukemia cutis in an adolescent boy. 61
10084909 1999
37
"Aleukemic" granulomatous leukemia cutis. 61
9700385 1998
38
[Monocytic aleukemic leukemia cutis]. 61
9676121 1998
39
Aleukemic leukemia cutis in a patient with acute lymphoblastic leukemia. 61
9555803 1998
40
Aleukemic "leukemia cutis" of monocytic lineage. 61
9146562 1997
41
Aleukemic leukemia cutis preceding overt acute myeloid leukemia in myelodysplastic syndrome. 61
8980276 1997
42
Lymphocytic aleukemic leukemia cutis. 61
8912603 1996
43
Aleukemic monocytic leukemia cutis. 61
8577191 1996
44
Skin involvement in myelogenous leukemia: morphologic and immunophenotypic heterogeneity of skin infiltrates. 61
7824512 1994
45
Acute myelomonocytic leukemia presenting as a benign-appearing cutaneous eruption. 61
2334186 1990
46
Aleukemic leukemia cutis. 61
2406302 1990
47
[Monocytic aleukemic leukemia cutis]. 61
3070080 1988
48
Aleukemic leukemia cutis. 61
3729513 1986
49
Aleukemic leukemia cutis. An unusual presentation of acute myelomonocytic leukemia. 61
2943614 1986
50
Aleukemic leukemia cutis: juvenile chronic granulocytic leukemia presenting with figurate cutaneous lesions. 61
6579062 1983

Variations for Aleukemic Leukemia Cutis

Expression for Aleukemic Leukemia Cutis

Search GEO for disease gene expression data for Aleukemic Leukemia Cutis.

Pathways for Aleukemic Leukemia Cutis

Pathways related to Aleukemic Leukemia Cutis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.15 CD33 ANPEP
2 10.99 SPN MPO CD33 ANPEP
3 10.85 MPO ANPEP

GO Terms for Aleukemic Leukemia Cutis

Biological processes related to Aleukemic Leukemia Cutis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.62 SPN RARA NPM1 CD33
2 negative regulation of apoptotic process GO:0043066 9.43 RARA NPM1 MPO
3 neutrophil degranulation GO:0043312 9.33 MPO CD33 ANPEP
4 negative regulation of cell proliferation GO:0008285 9.13 RARA NPM1 CD33
5 negative regulation of tumor necrosis factor production GO:0032720 8.62 RARA CD33

Molecular functions related to Aleukemic Leukemia Cutis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 8.8 RARA CD33 ANPEP

Sources for Aleukemic Leukemia Cutis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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