Aliases & Classifications for Alexia

MalaCards integrated aliases for Alexia:

Name: Alexia 12 77 15 74
Dyslexia, Acquired 45 74
Dyslexia 45 74
Acquired Dyslexia 12
Aphemesthaesia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13417
ICD9CM 36 315.01
SNOMED-CT 69 9236007

Summaries for Alexia

Disease Ontology : 12 An agnosia that is a loss of the ability to recognize text.

MalaCards based summary : Alexia, also known as dyslexia, acquired, is related to agraphia and acute disseminated encephalomyelitis, and has symptoms including scanning speech and aprosodia. An important gene associated with Alexia is LBR (Lamin B Receptor), and among its related pathways/superpathways is Spinal Cord Injury. The drugs Rivastigmine and Cholinesterase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and bone, and related phenotype is renal/urinary system.

Wikipedia : 77 Dyslexia, also known as reading disorder, is characterized by trouble with reading despite normal... more...

Related Diseases for Alexia

Diseases related to Alexia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 158)
# Related Disease Score Top Affiliating Genes
1 agraphia 32.3 KANTR MBP PPP3CA
2 acute disseminated encephalomyelitis 30.1 AQP4 MBP
3 head injury 30.1 APOE LBR
4 multiple sclerosis 30.0 APOE AQP4 MBP
5 stroke, ischemic 29.5 APOE AQP4 MBP
6 dyslexia 1 12.6
7 dyslexia 2 12.5
8 dyslexia 9 12.1
9 dyslexia 3 12.1
10 dyslexia 6 12.1
11 dyslexia 5 12.1
12 dyslexia 8 12.1
13 stormorken syndrome 11.6
14 learning disability 11.5
15 agnosia 11.5
16 dyscalculia 11.5
17 dyslexia 11.4
18 reading disorder 11.4
19 visual verbal agnosia 11.1
20 inclusion body myopathy with early-onset paget disease and frontotemporal dementia 11.1
21 progressive non-fluent aphasia 11.1
22 dysgraphia 10.9
23 apraxia 10.6
24 attention deficit-hyperactivity disorder 10.5
25 pol iii-related leukodystrophies 10.5
26 aphasia 10.5
27 dysphasia, familial developmental 10.5
28 specific language impairment 10.5
29 autism 10.4
30 prosopagnosia 10.3
31 schizophrenia 10.3
32 anxiety 10.3
33 dementia 10.3
34 strabismus 10.2
35 mechanical strabismus 10.2
36 visual agnosia 10.2
37 posterior cortical atrophy 10.2
38 brain injury 10.2 APOE MBP
39 developmental coordination disorder 10.2
40 developmental dyspraxia 10.2
41 semantic dementia 10.2
42 depression 10.1
43 oculomotor nerve paralysis 10.1 KANTR MBP
44 third cranial nerve disease 10.1 KANTR MBP
45 central pontine myelinolysis 10.1 AQP4 MBP
46 tabes dorsalis 10.1 KANTR MBP
47 intracranial vasospasm 10.1 APOE KANTR
48 anterior spinal artery syndrome 10.1 KANTR MBP
49 transverse myelitis 10.1 AQP4 MBP
50 myelitis 10.1 AQP4 MBP

Graphical network of the top 20 diseases related to Alexia:



Diseases related to Alexia

Symptoms & Phenotypes for Alexia

UMLS symptoms related to Alexia:


scanning speech, aprosodia

MGI Mouse Phenotypes related to Alexia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 8.92 APOE AQP4 LBR PPP3CA

Drugs & Therapeutics for Alexia

Drugs for Alexia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 79)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rivastigmine Approved, Investigational Phase 4 123441-03-2 77991
2 Cholinesterase Inhibitors Phase 4
3 Protective Agents Phase 4
4 Cholinergic Agents Phase 4
5 Neurotransmitter Agents Phase 4,Phase 3
6 Neuroprotective Agents Phase 4
7 Sodium-Glucose Transporter 2 Inhibitors Phase 4
8 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,... Phase 4
9 Hypoglycemic Agents Phase 4,Phase 3
10 Protein Kinase Inhibitors Phase 4
11 Imatinib Mesylate Phase 4 220127-57-1 123596
12
Ibuprofen Approved Phase 3 15687-27-1 3672
13
Quinidine Approved, Investigational Phase 3 56-54-2 441074
14
Guaifenesin Approved, Investigational, Vet_approved Phase 3 93-14-1 3516
15
Dextromethorphan Approved Phase 3 125-71-3 5362449 5360696
16
Zinc Approved, Investigational Phase 3 7440-66-6 32051
17
Pancrelipase Approved, Investigational Phase 3 53608-75-6
18
Insulin Detemir Approved Phase 3 169148-63-4 5311023
19
Lenalidomide Approved Phase 3 191732-72-6 216326
20
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
21
Bortezomib Approved, Investigational Phase 3 179324-69-7 387447 93860
22
Melphalan Approved Phase 3 148-82-3 460612 4053
23 Daratumumab Approved Phase 3 945721-28-8
24
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
25
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
26 Anti-Inflammatory Agents Phase 3
27 Cromolyn Sodium Phase 3
28 Excitatory Amino Acid Antagonists Phase 3
29 Quinidine gluconate Phase 3
30 Antitussive Agents Phase 3
31 Respiratory System Agents Phase 3
32 Chlorpheniramine, phenylpropanolamine drug combination Phase 3
33 Excitatory Amino Acids Phase 3
34 pancreatin Phase 3
35 Insulin, Long-Acting Phase 3
36 insulin Phase 3
37 Insulin, Globin Zinc Phase 3
38 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
39 Gastrointestinal Agents Phase 3
40 Hormones Phase 3,Phase 2
41 Immunoglobulins Phase 3
42 Antibodies, Monoclonal Phase 3
43 Alkylating Agents Phase 3,Phase 2
44
protease inhibitors Phase 3
45 Peripheral Nervous System Agents Phase 3
46 HIV Protease Inhibitors Phase 3
47 Immunosuppressive Agents Phase 3
48 Antiemetics Phase 3
49 Angiogenesis Inhibitors Phase 3
50 glucocorticoids Phase 3

Interventional clinical trials:

(show all 28)
# Name Status NCT ID Phase Drugs
1 Effects of Rivastigmine Patch on Activities of Daily Living and Cognition in Patients With Severe Dementia of the Alzheimer's Type (ACTION) (Study Protocol CENA713DUS44, NCT00948766) and a 24 Week Open-label Extension to Study CENA713DUS44 Completed NCT00948766 Phase 4 Rivastigmine 4.6 mg/24 h (5 cm^2);Rivastigmine 9.5 mg/24 h (10 cm^2);Rivastigmine 13.3 mg/24 h (15 cm^2);Placebo
2 Effects of Dapagliflozin on Central Hemodynamics and Urine Albumin Excretion in Patients With Type 2 Diabetes. Recruiting NCT02887677 Phase 4 Dapagliflozin;Placebo
3 Chemotherapy and Imatinib in Young Adults With Acute Lymphoblastic Leukemia Ph (BCR-ABL) POSITIVE Recruiting NCT01491763 Phase 4 Imatinib
4 Safety and Efficacy Study of ALZT-OP1 in Subjects With Evidence of Early Alzheimer's Disease Recruiting NCT02547818 Phase 3 ALZT-OP1a;ALZT-OP1b
5 Long Term, Extension Study of the Safety and Efficacy of AVP-786 for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type Recruiting NCT02446132 Phase 3 AVP-786
6 Cystic Fibrosis - Insulin Deficiency, Early Action Recruiting NCT01100892 Phase 3 Once-daily insulin detemir
7 Treatment for Elderly Fit Newly Diagnosed Multiple Myeloma Patients Aged Between 65 and 80 Years Recruiting NCT03742297 Phase 3 Lenalidomide.;Carfilzomib;Bortezomib;Daratumumab;Dexamethasone;Prednisone;Melphalan
8 Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type Active, not recruiting NCT02442778 Phase 3 AVP-786;Placebo
9 Phase II Trial of Seizure Prophylaxis in Suspected Primary Glioma Patients Undergoing Craniotomy Recruiting NCT03436433 Phase 2 Lacosamide;Levetiracetam
10 Treatments of the Necrosed Immature Teeth (REV) Recruiting NCT02064517 Phase 2
11 Randomized Trial in Advanced, Metastatic or Unresectable Soft Tissue Sarcoma After Failure of Standard Treatments. Not yet recruiting NCT03838744 Phase 2 Standard arm: Trabectedin in monotherapy;Experimental arm: Trabectedin + Olaparib
12 Brain Mechanisms Underlying Reading Improvement in Central Alexia Completed NCT02062619 Not Applicable
13 Multimodal Treatment of Phonological Alexia: Behavioral & fMRI Outcomes Completed NCT00827268 Not Applicable
14 Clinical Impact of the FilmArray Blood Culture Identification Panel Performed on Positive Blood Cultures From Intensive Care Patients With Septicemia Completed NCT03943719
15 Toxin Retrospective Study Completed NCT03042052 detrusor infection of Botulinum toxin
16 Therapy for Reading Problems in Adults After Brain Injury Completed NCT00064805 Not Applicable
17 Chaplain Family Project Trial Recruiting NCT03702634 Not Applicable
18 Utility of Postoperative Bracing: A Single-institution, Randomized-control Trial Comparing Brace to No-brace for Patients Undergoing Long-segment Fusion for Spinal Deformity Recruiting NCT03947541 Not Applicable
19 On-Q Catheter Caregiver Education Recruiting NCT03372889 Not Applicable
20 Alcohol, Inflammation, and Mindfulness Study Recruiting NCT02994043 Not Applicable
21 Analysis of Natural Killer Cell Activity (NKA) in Whole Blood in High Risk Subjects Undergoing Colonoscopy Recruiting NCT03249727 Not Applicable
22 WallFlex Pancreatic Metal Stent for Pancreatic Duct Strictures Recruiting NCT02802020 Not Applicable
23 Transcutaneous Electrical Nerve Stimulation (TENS) for Lower Urinary Tract Disorders in Parkinson's Syndrome Recruiting NCT02190851 Not Applicable
24 Laser Ablation of Abnormal Neurological Tissue Using Robotic NeuroBlate System Recruiting NCT02392078
25 App-delivered Therapy for Arabic Readers With Hemianopic Alexia Active, not recruiting NCT02482350 Not Applicable
26 Treatment for Reading and Writing Deficits Following Acquired Brain Injury Enrolling by invitation NCT03662243
27 Trial Measuring the Clinical Impact of the FilmArray® Pneumonia Panel in Critically Ill Not yet recruiting NCT03943732 Not Applicable
28 Care of AcromioClavicular Arthropathy in Manual Medicine Versus Corticosteroid Infiltration (ACAM) Not yet recruiting NCT03951480 Not Applicable Corticosteroids infiltration

Search NIH Clinical Center for Alexia

Cochrane evidence based reviews: dyslexia

Genetic Tests for Alexia

Anatomical Context for Alexia

MalaCards organs/tissues related to Alexia:

42
Brain, Temporal Lobe, Bone, Eye, Whole Blood, Parietal Lobe, Cortex

Publications for Alexia

Articles related to Alexia:

(show top 50) (show all 388)
# Title Authors Year
1
Multi-step treatment for acquired alexia and agraphia (Part I): efficacy, generalisation, and identification of beneficial treatment steps. ( 28421858 )
2019
2
Multi-step treatment for acquired alexia and agraphia (part II): a dual-route error scoring system. ( 28421910 )
2019
3
Shape-similar errors in Chinese pure alexia. ( 30777910 )
2019
4
How does iReadMore therapy change the reading network of patients with central alexia? ( 31085605 )
2019
5
The neural substrates of improved phonological processing following successful treatment in a case of phonological alexia and agraphia. ( 29350575 )
2018
6
Hypothalamic relapse of a cardiac large B-cell lymphoma presenting with memory loss, confabulation, alexia-agraphia, apathy, hypersomnia, appetite disturbances and diabetes insipidus. ( 30150329 )
2018
7
Cardiac Sarcoidosis as an Uncommon Etiology for Posterior Circulation Stroke Presenting with Alexia without Agraphia. ( 30652036 )
2018
8
Pure alexia: two cases and a new neuroanatomical classification. ( 29181626 )
2018
9
Do all visual deficits cause pure alexia? Dissociations between visual processing and reading suggest "no". ( 29902728 )
2018
10
Visual crowding in pure alexia and acquired prosopagnosia. ( 29902952 )
2018
11
Randomized trial of iReadMore word reading training and brain stimulation in central alexia. ( 29912350 )
2018
12
Dorsal and ventral visual stream contributions to preserved reading ability in patients with central alexia. ( 30005371 )
2018
13
When mild pure alexia may not be reducible to hemianopic alexia. ( 30033810 )
2018
14
Alexia Without Agraphia: A Rare Entity. ( 28690938 )
2017
15
Pure alexia in a patient with multiple sclerosis. ( 27770273 )
2017
16
A formal analysis of alexia in persistent aura and a comparison to acquired pure alexia. ( 28376693 )
2017
17
Reading on the right when there's nothing left? Probabilistic tractography reveals hemispheric asymmetry in pure alexia. ( 28789579 )
2017
18
Face perception in pure alexia: Complementary contributions of the left fusiform gyrus to facial identity and facial speech processing. ( 28964939 )
2017
19
Prosopometamorphopsia and alexia following left splenial corpus callosum infarction: Case report and literature review. ( 29260005 )
2017
20
Alexia Without Agraphia in a Right-Handed Individual Following Right Occipital Stroke. ( 26397830 )
2016
21
A 71-Year-Old Man Presenting with Headache, Blurry Vision and Alexia without Agraphia. ( 27647576 )
2016
22
Behavioural and eye-movement outcomes in response to text-based reading treatment for acquired alexia. ( 25582781 )
2016
23
Successful remote delivery of a treatment for phonological alexia via telerehab. ( 26018197 )
2016
24
Double Disassociation of Anosognosia for Alexia and Simultanagnosia but Quantitative Awareness of Optic Ataxia. ( 26368835 )
2016
25
Glioblastoma Presenting with Pure Alexia and Palinopsia Involving the Left Inferior Occipital Gyrus and Visual Word Form Area Evaluated with Functional Magnetic Resonance Imaging and Diffusion Tensor Imaging Tractography. ( 26748167 )
2016
26
Visual attention in posterior stroke and relations to alexia. ( 26970141 )
2016
27
Brain mechanisms of recovery from pure alexia: A single case study with multiple longitudinal scans. ( 27422538 )
2016
28
Ideographic Alexia without Involvement of the Fusiform Gyrus in a Korean Stroke Patient: A Serial Functional Magnetic Resonance Imaging Study. ( 30906347 )
2016
29
Acquired dyslexia in Serbian speakers with Broca's and Wernicke's aphasia. ( 27135368 )
2016
30
Surface errors without semantic impairment in acquired dyslexia: a voxel-based lesion-symptom mapping study. ( 26966139 )
2016
31
Treatment for Alexia With Agraphia Following Left Ventral Occipito-Temporal Damage: Strengthening Orthographic Representations Common to Reading and Spelling. ( 26110814 )
2015
32
Fast word reading in pure alexia: "fast, yet serial". ( 24592898 )
2015
33
Is radical-by-radical reading strategy effective for Chinese pure alexia? A case study. ( 25068672 )
2015
34
Transcranial direct current stimulation for pure alexia: effects on brain and behavior. ( 25511797 )
2015
35
Vanishing splenial lesion presenting as alexia with dysgraphia. ( 25683766 )
2015
36
The effects of homonymous hemianopia in experimental studies of alexia. ( 25708175 )
2015
37
Untangling letter confusability and word length effects in pure alexia. ( 26745321 )
2015
38
Training Pseudoword Reading in Acquired Dyslexia: A Phonological Complexity Approach. ( 26085708 )
2015
39
[A case of pure alexia and foreign accent syndrome following acute encephalopathy in the presence of anti-glutamate receptor antibodies]. ( 26289758 )
2015
40
Right Brain: A reading specialist with alexia without agraphia: Teacher interrupted. ( 24379102 )
2014
41
Posterior cerebral artery stroke presenting as alexia without agraphia. ( 24935413 )
2014
42
Progressive Wallerian Degeneration of the Corpus Callosal Splenium in a Patient with Alexia Without Agraphia: Advanced MR Findings. ( 25489886 )
2014
43
Bilateral hemispheric processing of words and faces: evidence from word impairments in prosopagnosia and face impairments in pure alexia. ( 23250954 )
2014
44
Alexia due to ischemic stroke of the visual word form area. ( 23528139 )
2014
45
Fluorodeoxyglucose F18 positron emission tomography in a case of slowly progressive pure alexia. ( 23998338 )
2014
46
Reading faces: investigating the use of a novel face-based orthography in acquired alexia. ( 24463310 )
2014
47
Effects of intensive phonomotor treatment on reading in eight individuals with aphasia and phonological alexia. ( 24686537 )
2014
48
What lies beneath: a comparison of reading aloud in pure alexia and semantic dementia. ( 24702272 )
2014
49
From word superiority to word inferiority: visual processing of letters and words in pure alexia. ( 24801564 )
2014
50
On compensatory strategies and computational models: the case of pure alexia. ( 24863010 )
2014

Variations for Alexia

Expression for Alexia

Search GEO for disease gene expression data for Alexia.

Pathways for Alexia

Pathways related to Alexia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.88 AQP4 MBP PPP3CA

GO Terms for Alexia

Biological processes related to Alexia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cholesterol biosynthetic process GO:0006695 8.96 APOE LBR
2 positive regulation of endocytosis GO:0045807 8.62 APOE PPP3CA

Sources for Alexia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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