Alexithymia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ALX002 MIFTS: 42	Alexithymia Categories: Mental diseases
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Aliases & Classifications for Alexithymia

MalaCards integrated aliases for Alexithymia:

Name: Alexithymia ¹² ¹⁵

Classifications:

MalaCards categories:
Anatomical: Mental diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060131

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Summaries for Alexithymia

Disease Ontology : ¹² An agnosia that is a deficiency in understanding, processing, or describing emotions.

MalaCards based summary : Alexithymia is related to eating disorder and pathological gambling. An important gene associated with Alexithymia is ANKK1 (Ankyrin Repeat And Kinase Domain Containing 1), and among its related pathways/superpathways are Folate Metabolism and Circadian rythm related genes. The drugs Ketamine and Cycloserine have been mentioned in the context of this disorder. Affiliated tissues include brain, breast and testes, and related phenotypes are endocrine/exocrine gland and nervous system

Wikipedia : ⁷⁶ Alexithymia /ˌeɪlɛksəˈθaɪmiə/ is a personality construct characterized by the subclinical inability to... more...

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Related Diseases for Alexithymia

Diseases related to Alexithymia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 207)

#	Related Disease	Score	Top Affiliating Genes
1	eating disorder	30.8	COMT DRD2 SLC6A4
2	pathological gambling	30.7	DRD2 SLC6A4
3	fibromyalgia	30.3	COMT IL6 SLC6A4
4	anxiety	30.3	COMT HTR1A SLC6A4
5	traumatic brain injury	30.2	COMT DRD2 IL6
6	brain injury	30.2	COMT DRD2 IL6
7	opioid addiction	30.2	COMT DRD2
8	paranoid schizophrenia	30.2	COMT SLC6A4
9	substance dependence	30.2	DRD2 IL6 SLC6A4
10	impulse control disorder	30.1	ANKK1 DRD2
11	somatoform disorder	30.0	COMT IL4
12	substance abuse	29.9	COMT DRD2 SLC6A4
13	panic disorder	29.8	COMT HTR1A SLC6A4
14	apnea, obstructive sleep	29.7	CRP IL6
15	borderline personality disorder	29.7	COMT HTR1A SLC6A4
16	alcohol abuse	29.7	ANKK1 DRD2 SLC6A4
17	post-traumatic stress disorder	29.6	COMT CRP DRD2 SLC6A4
18	personality disorder	29.5	COMT DRD2 HTR1A SLC6A4
19	generalized anxiety disorder	29.2	DRD2 HTR1A SLC6A4
20	antisocial personality disorder	29.1	ANKK1 COMT DRD2 SLC6A4
21	obsessive-compulsive disorder	29.1	COMT DRD2 HTR1A SLC6A4
22	premature ejaculation	29.1	COMT HTR1A SLC6A4
23	migraine without aura	29.0	DRD2 HTR1A SLC6A4
24	psychotic disorder	28.5	COMT DRD2 HTR1A SLC6A4
25	alcohol dependence	28.4	ANKK1 COMT DRD2 HTR1A SLC6A4
26	parkinson disease, late-onset	28.4	COMT DRD2 HTR1A SLC6A4
27	bipolar disorder	28.4	COMT DRD2 HTR1A SLC6A4
28	autism	28.3	COMT DRD2 HTR1A OXTR SLC6A4
29	chronic fatigue syndrome	28.2	COMT HTR1A IL6 SLC6A4
30	major depressive disorder	28.1	COMT DRD2 HTR1A IL6 SLC6A4
31	disease of mental health	27.8	COMT DRD2 HTR1A OXTR SLC6A4
32	mood disorder	27.8	COMT DRD2 HTR1A IL6 SLC6A4
33	attention deficit-hyperactivity disorder	27.7	ANKK1 COMT DRD2 HTR1A SLC6A4
34	social emotional agnosia	11.0
35	alcohol-induced mental disorder	10.7	DRD2 SLC6A4
36	schizophreniform disorder	10.7	COMT DRD2
37	alcoholic psychosis	10.7	DRD2 SLC6A4
38	polysubstance abuse	10.7	COMT DRD2
39	tardive dyskinesia	10.7	COMT DRD2
40	bruxism	10.7	DRD2 SLC6A4
41	taqi polymorphism	10.5	ANKK1 DRD2
42	heroin dependence	10.5	ANKK1 DRD2
43	depression	10.5
44	cold agglutinin disease	10.5	CRP IL6
45	cryopyrin-associated periodic syndrome	10.5	CRP IL6
46	cardiogenic shock	10.4	CRP IL6
47	acute cholangitis	10.4	CRP IL6
48	neutrophilia, hereditary	10.4	CRP IL6
49	uremic pruritus	10.4	CRP IL6
50	spinal disease	10.4	CRP IL6

Graphical network of the top 20 diseases related to Alexithymia:

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Symptoms & Phenotypes for Alexithymia

MGI Mouse Phenotypes related to Alexithymia:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland	MP:0005379	9.43	COMT DRD2 IL4 IL6 OXTR SLC6A4
2	nervous system	MP:0003631	9.17	IL6 OXTR SLC6A4 COMT DRD2 HTR1A

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Drugs & Therapeutics for Alexithymia

Drugs for Alexithymia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 62)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Ketamine

Approved, Vet_approved

Phase 4

6740-88-1

3821

Cycloserine

Approved

Phase 4

68-41-7

401 6234

Sertraline

Approved

Phase 4

79617-96-2

68617

Analgesics

Phase 4

Renal Agents

Phase 4

Central Nervous System Depressants

Phase 4,Phase 2

Neurotransmitter Agents

Phase 4,Phase 2

Anesthetics

Phase 4

Anesthetics, Dissociative

Phase 4

Anesthetics, General

Phase 4

Anesthetics, Intravenous

Phase 4

Peripheral Nervous System Agents

Phase 4

Anti-Bacterial Agents

Phase 4

Antibiotics, Antitubercular

Phase 4

Excitatory Amino Acid Antagonists

Phase 4

Excitatory Amino Acids

Phase 4

Antidepressive Agents

Phase 4

Anti-Infective Agents

Phase 4,Phase 1

Antitubercular Agents

Phase 4

Antimetabolites

Phase 4

Serotonin Agents

Phase 4,Phase 2

Serotonin Uptake Inhibitors

Phase 4

Neurotransmitter Uptake Inhibitors

Phase 4,Phase 2

Psychotropic Drugs

Phase 4,Phase 2

Serotonin

Investigational, Nutraceutical

Phase 4,Phase 2

50-67-9

5202

Zopiclone

Approved

Phase 2

43200-80-2

5735

Oxytocin

Approved, Vet_approved

Phase 2

50-56-6

439302 53477758

3,4-Methylenedioxyamphetamine

Experimental, Illicit

Phase 2

4764-17-4

1614

Adrenergic Agents

Phase 2

Hallucinogens

Phase 2

N-Methyl-3,4-methylenedioxyamphetamine

Phase 2

Hypnotics and Sedatives

Phase 2

Oxytocics

Phase 2

Acetylcysteine

Approved, Investigational

Phase 1

616-91-1

12035

Respiratory System Agents

Phase 1

N-monoacetylcystine

Phase 1

Vitamins

Phase 1

Expectorants

Phase 1

Antidotes

Phase 1

Antioxidants

Phase 1

Protective Agents

Phase 1

Antiviral Agents

Phase 1

Hydrocortisone

Approved, Vet_approved

50-23-7

5754

Dopamine

Approved

51-61-6, 62-31-7

681

Norepinephrine

Approved

51-41-2

439260

Ethanol

Approved

64-17-5

702

Zinc oxide

Approved

Not Applicable

1314-13-2

Buprenorphine

Approved, Illicit, Investigational, Vet_approved

52485-79-7

40400 644073

Naloxone

Approved, Vet_approved

465-65-6

5284596

Cocaine

Approved, Illicit

50-36-2

5760 446220

Interventional clinical trials:

(show top 50) (show all 53)

#	Name	Status	NCT ID	Phase	Drugs
1	D-cycloserine for Relapse Prevention Following Intravenous Ketamine in Treatment-resistant Depression	Unknown status	NCT02772211	Phase 4	Ketamine;D-cycloserine;Placebo
2	Cognitive Behavioral Therapy Versus Sertraline in the Treatment of Post-Traumatic Stress Disorder	Completed	NCT00391430	Phase 4	Sertraline
3	Impact of a Group Intervention on Breast Cancer Patient's Adjustment and Emotion Regulation at the End of Treatment	Completed	NCT01797354	Phase 2
4	Effectiveness of BBT-I and Zopiclone for Chronic Insomnia	Completed	NCT03339583	Phase 2	Zopiclone
5	MDMA-assisted Therapy for Social Anxiety in Autistic Adults	Completed	NCT02008396	Phase 2	Placebo;MDMA
6	Pain and Stress Management for Fibromyalgia	Completed	NCT01287481	Phase 2
7	Autism Oxytocin Brain Project	Recruiting	NCT03033784	Phase 2	Oxytocin;Oxytocin;Oxytocin;Placebo
8	Ocytocine and Cerebral Activation in Relation With Attachement	Recruiting	NCT02847143	Phase 2	nasal oxytocin or placebo
9	Early Study of N-Acetylcysteine to Treat Deliberate Self-Harm in Adolescents	Completed	NCT01111734	Phase 1	fMRI
10	Neurobiological, Neuropsychological,Linguistic and Gestural Processes and Phenomena in Individuals With Alexithymia	Unknown status	NCT00830752
11	Psychological Impact in Diabetes: Intervention With Affect School and Basal Body Awareness	Unknown status	NCT01498614	Not Applicable
12	Psychopathological Risk Factors Associated With Conversion From Mild Cognitive Impairment to Dementia	Unknown status	NCT01436552
13	Halifax Treatment Refractory Depression Trial	Unknown status	NCT01141426	Not Applicable
14	The Emotion Builder: An Intervention for Emotional Deficits After Brain Injury	Completed	NCT02432300	Not Applicable
15	Online Treatment of Trichotillomania	Completed	NCT02044237	Not Applicable
16	Clinical Assessment and Psychosocial Impact of Psoriasis	Completed	NCT01964443
17	Outcomes of Mentalization-Based Treatment for Borderline Personality Disorder	Completed	NCT03295838	Not Applicable
18	Moderating Impact of Various Emotion Personality Factors on Salivary Cortisol Response to a TSST	Completed	NCT00451126
19	Effectiveness of Standard Emergency Department Psychiatric Treatment Associated With Treatment Delivery by a Suicide Prevention Center	Completed	NCT00641498	Not Applicable
20	Attention Bias Modification Treatment for Warzone-Related Posttraumatic Stress Disorder (PTSD)	Completed	NCT01564667	Not Applicable
21	Service Member Fatigue and Lack of Motivation Following Concussion	Completed	NCT01496586
22	Functional Neuroanatomy and Regional Metabolism Before and After Treatment With Duloxetine	Completed	NCT02658617
23	Research Project About Psychological Strain, Quality of Life and Emotional Awareness in Patients With Tinnitus	Completed	NCT01837368
24	Depression Online Assessment and Therapy	Completed	NCT02112266	Not Applicable
25	Mindfulness in Preparation to Bariatric Surgery	Completed	NCT02854306	Not Applicable
26	The Effectiveness of Mindfulness on Chronic Pain in Breast Cancer Survivors	Completed	NCT01674881	Not Applicable
27	Electrophysiological Correlates of Emotional and Crossmodal Stimuli Processing Among Alcohol-dependent Participants	Completed	NCT01633905
28	Plasticity of the Compassionate Brain	Completed	NCT01833104	Not Applicable
29	Stress Management for Irritable Bowel Syndrome	Completed	NCT01886027	Not Applicable
30	Mindfulness for Irritable Bowel Syndrome	Completed	NCT02794376	Not Applicable
31	Improving Happiness in Flanders	Completed	NCT02041741	Not Applicable
32	Chronic Low Back Pain: A Multidisciplinary Approach	Completed	NCT01993355	Not Applicable
33	Training to Reconnect With Emotional Awareness Therapy	Recruiting	NCT03414463	Not Applicable
34	Positive Emotion Regulation Training in Children, Adolescents and Young Adults With and Without Developmental Disorder	Recruiting	NCT02898298	Not Applicable
35	Re-nutrition in Severe Anorexia Nervosa	Recruiting	NCT02502617
36	CBT-Eb Plus EMDR Versus CBT-Eb in Patients With Eating Disorders	Recruiting	NCT03156959	Not Applicable
37	Stress Management in Obesity During a Thermal Spa Residential Program	Recruiting	NCT03578757	Not Applicable
38	Influence of Main Psychological and Social Factors on Primary Headaches	Recruiting	NCT03577548
39	Student Outcomes of Integrative Mental Health Services	Recruiting	NCT02877875	Not Applicable
40	Oculomotor Markers and Attachment in Adolescents	Recruiting	NCT02851810	Not Applicable
41	Randomized Controlled Study of the Efficacy of Hypnosis Versus Relaxation and Control in Neuropathic Pain	Recruiting	NCT02256371	Not Applicable
42	Improving Emotion Regulation Skills Among Adolescents Attempting to Lose Weight	Recruiting	NCT03393221	Not Applicable
43	Effectiveness of Buprenorphine/Naloxone	Recruiting	NCT02882412
44	A SYNdemic BASed INtervention for MSM With High Risk Behavior: Design of a Randomized Controlled Trial	Active, not recruiting	NCT02859935	Not Applicable
45	Mental Training for CFS Following EBV Infection in Adolescents	Active, not recruiting	NCT02499302	Not Applicable
46	Psychological Variables and Hyperglycemia in Diabetes Mellitus	Enrolling by invitation	NCT01714986	Not Applicable
47	Development of Reward Processing in Prenatally Exposed Adolescents and Young Adults	Enrolling by invitation	NCT03268759
48	Evaluation of Art-therapy on Alexithymia in Patients Suffering From Anorexia Nervosa and From Bulimia	Not yet recruiting	NCT03524443
49	Asthma, Smoking, Emotional Deficits	Not yet recruiting	NCT03312673
50	Automated Assessment Using Facial Coding	Not yet recruiting	NCT03551886	Not Applicable

Search NIH Clinical Center for Alexithymia

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Genetic Tests for Alexithymia

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Anatomical Context for Alexithymia

MalaCards organs/tissues related to Alexithymia:

⁴¹

Brain, Breast, Testes, Heart, Cortex, Skin, Eye

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Publications for Alexithymia

Articles related to Alexithymia:

(show top 50) (show all 715)

#	Title	Authors	Year
1	Attachment avoidance, alexithymia, and gender: Examining their associations with distress disclosure tendencies and event-specific disclosure. ( 29355345 )	O'Loughlin J.I....Wu A.D.	2018
2	Is alexithymia characterised by impaired interoception? Further evidence, the importance of control variables, and the problems with the Heartbeat Counting Task. ( 29803614 )	Murphy J....Bird G.	2018
3	Body talk: Sex differences in the influence of alexithymia on physical complaints among psychiatric outpatients. ( 29309955 )	Ogrodniczuk J.S....Abbass A.A.	2018
4	Affect labeling and other aspects of emotional experiences in relation to alexithymia following standardized emotion inductions. ( 29428774 )	Aaron R.V....Park S.	2018
5	Childhood Trauma and Functional Variants of 5-HTTLPR Are Independently Associated with Alexithymia in 5,283 Subjects from the General Population. ( 29306941 )	Terock J....Grabe H.J.	2018
6	Psychoeducation against depression, anxiety, alexithymia and fibromyalgia: a pilot study in primary care for patients on sick leave. ( 29693478 )	Melin E.O....Thulesius H.O.	2018
7	The functional and structural characteristics of the emotion network in alexithymia. ( 29695908 )	Han D....Sun X.	2018
8	Alexithymia and autistic traits as possible predictors for traits related to depression, anxiety, and stress: A multivariate statistical approach. ( 29882629 )	Fietz J....Silani G.	2018
9	Subjective and Objective: Alexithymia and Social Cognition in Eating Disorders. ( 29916406 )	Hason Rozenstein M....Latzer Y.	2018
10	Psychometric Properties of the Bermond-Vorst Alexithymia Questionnaire (BVAQ) in the General Population and a Clinical Population. ( 29740350 )	de Vroege L....van der Feltz-Cornelis C.M.	2018
11	Association of Internet addiction and alexithymia - A scoping review. ( 29429757 )	Mahapatra A....Sharma P.	2018
12	Alexithymia as a potential source of symptom over-reporting: An exploratory study in forensic patients and non-forensic participants. ( 29349809 )	Merckelbach H....A8 Campo J.	2018
13	Are alexithymia and empathy predicting factors of the resilience of medical residents in France? ( 29731450 )	Morice-Ramat A....Guihard G.	2018
14	Headache and Alexithymia in Children and Adolescents: What Is the Connection? ( 29449820 )	Natalucci G....Guidetti V.	2018
15	Association Between Alexithymia and Functional Gastrointestinal Disorders. ( 29922191 )	Kano M....Fukudo S.	2018
16	Do terrorists suffer from alexithymia? ( 29417660 )	Burns E.J.	2018
17	The influence of alexithymia on mobile phone addiction: The role of depression, anxiety and stress. ( 28926906 )	Gao T....Mei S.	2018
18	Language and alexithymia: Evidence for the role of the inferior frontal gyrus in acquired alexithymia. ( 29360519 )	Hobson H....Grafman J.	2018
19	Alexithymia and Somatosensory Amplification Link Perceived Psychosocial Stress and Somatic Symptoms in Outpatients with Psychosomatic Illness. ( 29748483 )	Nakao M....Takeuchi T.	2018
20	Symptom, alexithymia and self-image outcomes of Mentalisation-based treatment for borderline personality disorder: a naturalistic study. ( 29890960 )	LAPf J....RydAcn G.	2018
21	Assessing advanced theory of mind and alexithymia in patients suffering from enduring borderline personality disorder. ( 29360051 )	Pluta A....Kucharska K.	2018
22	The Relationship Between Alexithymia and Emotional Awareness: A Meta-Analytic Review of the Correlation Between TAS-20 and LEAS. ( 29713295 )	Maroti D....Bileviciute-Ljungar I.	2018
23	Bullying and alexithymia: Are there differences between traditional, cyber, combined bullies, and nonbullies in reading their own emotions? ( 29952143 )	Wachs S....Wright M.F.	2018
24	The Impact of Alexithymia on Emotion Dysregulation in Anorexia Nervosa and Bulimia Nervosa over Time. ( 29266572 )	Brown T.A....Kaye W.H.	2018
25	The relationship between alexithymia and headache impact: the role of somatization and pain catastrophizing. ( 29869297 )	Shim E.J....Park S.P.	2018
26	Influence of anxiety and alexithymia on brain activations associated with the perception of others' pain in autism. ( 29683406 )	Lassalle A....Hadjikhani N.	2018
27	Psychometric Properties of the 20-Item Toronto Alexithymia Scale in the Chilean Population. ( 29946289 )	GonzA!lez-Arias M....UrzA_a A.	2018
28	A scoping review of suicidality and alexithymia: The need to consider interoception. ( 29913380 )	Davey S....Collings S.	2018
29	Traumatic Experiences, Stressful Events, and Alexithymia in Chronic Migraine With Medication Overuse. ( 29867669 )	Bottiroli S....Tassorelli C.	2018
30	Looking at the eyes interferes with facial emotion recognition in alexithymia. ( 29792440 )	Fujiwara E.	2018
31	Alexithymia in Young Adults With Substance Use Disorders: Critical Issues About Specificity and Treatment Predictivity. ( 29872408 )	Parolin M....Simonelli A.	2018
32	Alexithymia Is Related to the Need for More Emotional Intensity to Identify Static Fearful Facial Expressions. ( 29942271 )	Starita F....Scarpazza C.	2018
33	Parental Alexithymia, Depression and Anxiety Levels of Children with Neurodevelopmental Disorders: A Comparative Study with Pervasive Developmental Disorders and ADHD. ( 29290095 )	Durukan I....GA1l H.	2017
34	Relationship between pathological gambling, alexithymia, and gambling type. ( 28211964 )	Bonnaire C....Varescon I.	2017
35	Moderating Effects of Alexithymia on Associations between the Therapeutic Alliance and the Outcome of Brief Psychodynamic-Interpersonal Psychotherapy for Multisomatoform Disorder. ( 29255429 )	Probst T....Lahmann C.	2017
36	Alexithymia as a Moderator of Treatment Outcomes in a Randomized Controlled Trial on Brief Psychodynamic Interpersonal Psychotherapy for Patients with Multisomatoform Disorder. ( 27884003 )	Probst T....Lahmann C.	2017
37	Reductions in Alexithymia and Emotion Dysregulation After Training Emotional Self-Awareness Following Traumatic Brain Injury: A Phase I Trial. ( 28060205 )	Neumann D....Hammond F.M.	2017
38	Prevalence and associated factors of alexithymia among adult prisoners in China: a cross-sectional study. ( 28768497 )	Chen L....Ling N.	2017
39	Childhood maltreatment is associated with attachment insecurities, dissociation and alexithymia in bipolar disorder. ( 29253803 )	Kefeli M.C....Boysan M.	2017
40	Psychopathology and alexithymia in patients with psoriasis. ( 28954100 )	Korkoliakou P....Douzenis A.	2017
41	Alexithymia as a mediator of the relationship between child sexual abuse and psychological distress in adolescence: A short-term longitudinal study. ( 29274605 )	HAcbert M....OussaA^d E.	2017
42	Rash Impulsiveness and Negative Mood, but not Alexithymia or Reward Sensitivity, Differentiate Young to Middle-Aged Chronic Daily Smokers from Never-Smokers. ( 28895792 )	Lyvers M....Thorberg F.A.	2017
43	A Study of the Characteristics of Alexithymia and Emotion Regulation in Patients with Depression. ( 28765680 )	Zhang H....Song L.	2017
44	Cognitive factors and post-partum depression: What is the influence of general personality traits, rumination, maternal self-esteem, and alexithymia? ( 29282785 )	Denis A....Luminet O.	2017
45	&quot;Lacking warmth&quot;: Alexithymia trait is related to warm-specific thermal somatosensory processing. ( 28735971 )	Borhani K....Haggard P.	2017
46	Alexithymia and Suicide Risk in Psychiatric Disorders: A Mini-Review. ( 28855878 )	De Berardis D....Di Giannantonio M.	2017
47	On the Processes Underlying the Relationship Between Alexithymia and Gambling Severity. ( 28866795 )	NoAl X....Fantini-Hauwel C.	2017
48	Alexithymia as a Transdiagnostic Precursor to Empathy Abnormalities: The Functional Role of the Insula. ( 29312079 )	Valdespino A....Richey J.A.	2017
49	The mediating effects of cognitive emotion regulation strategies on the relationship between alexithymia and physical symptoms: Evidence from Iranian asthmatic patients. ( 27898375 )	Ghorbani F....Akbari H.	2017
50	Depression differed by midnight cortisol secretion, alexithymia and anxiety between diabetes types: a cross sectional comparison. ( 28931368 )	Melin E.O....Thulesius H.O.	2017

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Genes for Alexithymia

Genes related to Alexithymia (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ANKK1	Ankyrin Repeat And Kinase Domain Containing 1	Protein Coding	22.96	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	SLC6A4	Solute Carrier Family 6 Member 4	Protein Coding	22.24	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	DRD2	Dopamine Receptor D2	Protein Coding	22.15	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	OXTR	Oxytocin Receptor	Protein Coding	21.91	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	COMT	Catechol-O-Methyltransferase	Protein Coding	21.9	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	TAS2R38	Taste 2 Receptor Member 38	Protein Coding	21.2	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	CRP	C-Reactive Protein	Protein Coding	20.9	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	IL4	Interleukin 4	Protein Coding	20.88	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	HTR1A	5-Hydroxytryptamine Receptor 1A	Protein Coding	20.63	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	IL6	Interleukin 6	Protein Coding	20.1	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

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Variations for Alexithymia

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Expression for Alexithymia

Search GEO for disease gene expression data for Alexithymia.

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Pathways for Alexithymia

Pathways related to Alexithymia according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Folate Metabolism ¹ Show member pathways Selenium Micronutrient Network ¹ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	11.94	CRP IL4 IL6
2	Circadian rythm related genes ¹	11.9	DRD2 IL6 SLC6A4
3	cAMP signaling pathway ³⁷ Show member pathways Hydroxycarboxylic acid-binding receptors ⁶⁶	11.8	DRD2 HTR1A OXTR
4	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	11.34	HTR1A IL6 SLC6A4
5	Development and heterogeneity of the ILC family ¹	10.96	IL4 IL6
6	Cytokines and Inflammatory Response ¹	10.85	IL4 IL6
7	Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics ⁶¹	10.7	HTR1A SLC6A4
8	Neurotransmitter Clearance In The Synaptic Cleft ⁶⁶ Show member pathways Dopamine clearance from the synaptic cleft ⁶⁶ Enzymatic degradation of dopamine by COMT ⁶⁶ Enzymatic degradation of Dopamine by monoamine oxidase ⁶⁶ melatonin degradation II ¹ Metabolism of serotonin ⁶⁶ Serotonin clearance from the synaptic cleft ⁶⁶	10.57	COMT SLC6A4
9	Overview of nanoparticle effects ¹	9.9	CRP IL6

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GO Terms for Alexithymia

Biological processes related to Alexithymia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	response to cocaine	GO:0042220	9.43	DRD2 OXTR
2	acute-phase response	GO:0006953	9.4	CRP IL6
3	response to amphetamine	GO:0001975	9.37	DRD2 OXTR
4	vasoconstriction	GO:0042310	9.32	HTR1A SLC6A4
5	dopamine metabolic process	GO:0042417	9.26	COMT DRD2
6	response to drug	GO:0042493	9.26	COMT DRD2 OXTR SLC6A4
7	negative regulation of lipid storage	GO:0010888	9.16	CRP IL6
8	sperm ejaculation	GO:0042713	8.62	OXTR SLC6A4

Molecular functions related to Alexithymia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	obsolete signal transducer activity	GO:0004871	8.92	DRD2 HTR1A OXTR TAS2R38

Sources

Sources for Alexithymia

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

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