Alexithymia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ALX002 MIFTS: 43	Alexithymia Categories: Mental diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Alexithymia

MalaCards integrated aliases for Alexithymia:

Name: Alexithymia ¹² ¹⁵

Classifications:

MalaCards categories:
Anatomical: Mental diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060131

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Summaries for Alexithymia

Disease Ontology : ¹² An agnosia that is a deficiency in understanding, processing, or describing emotions.

MalaCards based summary : Alexithymia is related to eating disorder and anxiety. An important gene associated with Alexithymia is ANKK1 (Ankyrin Repeat And Kinase Domain Containing 1), and among its related pathways/superpathways are Selenium Micronutrient Network and Circadian rythm related genes. The drugs Cycloserine and Ketamine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and breast, and related phenotypes are endocrine/exocrine gland and nervous system

Wikipedia : ⁷⁷ Alexithymia is a personality construct characterized by the subclinical inability to identify and... more...

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Related Diseases for Alexithymia

Diseases related to Alexithymia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 249)

#	Related Disease	Score	Top Affiliating Genes
1	eating disorder	31.0	COMT DRD2 SLC6A4
2	anxiety	30.8	COMT HTR1A SLC6A4
3	fibromyalgia	30.6	COMT IL6 SLC6A4
4	traumatic brain injury	30.5	COMT DRD2 IL6
5	brain injury	30.5	COMT DRD2 IL6
6	pathological gambling	30.5	DRD2 SLC6A4
7	panic disorder	30.4	COMT HTR1A SLC6A4
8	somatoform disorder	30.4	COMT IL4
9	post-traumatic stress disorder	30.2	COMT CRP DRD2 SLC6A4
10	borderline personality disorder	30.2	COMT HTR1A SLC6A4
11	inflammatory bowel disease	30.1	CRP IL4 IL6
12	substance abuse	30.0	COMT DRD2 SLC6A4
13	paranoid schizophrenia	29.9	COMT SLC6A4
14	alcohol abuse	29.9	ANKK1 DRD2 SLC6A4
15	substance dependence	29.8	DRD2 IL6 SLC6A4
16	personality disorder	29.8	ANKK1 COMT DRD2 HTR1A SLC6A4
17	mental depression	29.7	COMT HTR1A SLC6A4
18	premature ejaculation	29.6	HTR1A SLC6A4
19	social phobia	29.6	DRD2 HTR1A SLC6A4
20	obsessive-compulsive disorder	29.5	COMT DRD2 HTR1A OXTR SLC6A4
21	periodontitis	29.5	CRP IL4 IL6
22	intermittent claudication	29.5	CRP IL6
23	generalized anxiety disorder	29.5	COMT DRD2 HTR1A SLC6A4
24	migraine with or without aura 1	29.5	COMT DRD2 HTR1A SLC6A4
25	antisocial personality disorder	29.4	ANKK1 COMT DRD2 SLC6A4
26	tobacco addiction	29.4	ANKK1 COMT DRD2 SLC6A4
27	migraine without aura	29.4	DRD2 HTR1A SLC6A4
28	bipolar disorder	29.3	COMT DRD2 HTR1A SLC6A4
29	chronic fatigue syndrome	29.3	COMT HTR1A IL6 SLC6A4
30	psychotic disorder	29.1	COMT DRD2 HTR1A SLC6A4
31	parkinson disease, late-onset	29.1	COMT DRD2 HTR1A SLC6A4
32	major depressive disorder	28.9	COMT DRD2 HTR1A IL6 OXTR SLC6A4
33	alcohol dependence	28.9	ANKK1 COMT DRD2 HTR1A SLC6A4
34	mood disorder	28.9	COMT DRD2 HTR1A IL6 SLC6A4
35	disease of mental health	28.7	COMT DRD2 HTR1A IL6 OXTR SLC6A4
36	attention deficit-hyperactivity disorder	28.7	ANKK1 COMT DRD2 HTR1A SLC6A4
37	social emotional agnosia	11.1
38	depression	10.7
39	autism	10.4
40	alcohol-induced mental disorder	10.4	DRD2 SLC6A4
41	alcoholic psychosis	10.3	DRD2 SLC6A4
42	schizophreniform disorder	10.3	COMT DRD2
43	polysubstance abuse	10.3	COMT DRD2
44	tardive dyskinesia	10.3	COMT DRD2
45	pain - chronic	10.3
46	opioid addiction	10.3	COMT DRD2
47	anorexia nervosa	10.3
48	psoriasis	10.3
49	impulse control disorder	10.3	ANKK1 DRD2
50	schizophrenia	10.3

Graphical network of the top 20 diseases related to Alexithymia:

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Symptoms & Phenotypes for Alexithymia

MGI Mouse Phenotypes related to Alexithymia:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland	MP:0005379	9.43	COMT DRD2 IL4 IL6 OXTR SLC6A4
2	nervous system	MP:0003631	9.17	COMT DRD2 HTR1A IL4 IL6 OXTR

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Drugs & Therapeutics for Alexithymia

Drugs for Alexithymia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 72)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Cycloserine

Approved

Phase 4

68-41-7

401 6234

Ketamine

Approved, Vet_approved

Phase 4

6740-88-1

3821

Sertraline

Approved

Phase 4

79617-96-2

68617

Antidepressive Agents

Phase 4

Central Nervous System Depressants

Phase 4,Phase 2,Not Applicable

Peripheral Nervous System Agents

Phase 4

Anti-Bacterial Agents

Phase 4

Excitatory Amino Acid Antagonists

Phase 4

Antimetabolites

Phase 4

Anti-Infective Agents

Phase 4,Phase 1,Not Applicable

Neurotransmitter Agents

Phase 4,Phase 2

Anesthetics

Phase 4

Anesthetics, Dissociative

Phase 4

Anesthetics, Intravenous

Phase 4

Antibiotics, Antitubercular

Phase 4

Anti-Infective Agents, Urinary

Phase 4

Antitubercular Agents

Phase 4

Analgesics

Phase 4

Anesthetics, General

Phase 4

Renal Agents

Phase 4

Excitatory Amino Acids

Phase 4

Serotonin Agents

Phase 4,Phase 2

Serotonin Uptake Inhibitors

Phase 4

Psychotropic Drugs

Phase 4,Phase 2,Not Applicable

Neurotransmitter Uptake Inhibitors

Phase 4,Phase 2

Serotonin

Investigational, Nutraceutical

Phase 4,Phase 2

50-67-9

5202

Oxytocin

Approved, Vet_approved

Phase 2,Not Applicable

50-56-6

439302 53477758

Zopiclone

Approved

Phase 2

43200-80-2

5735

3,4-Methylenedioxyamphetamine

Experimental, Illicit

Phase 2

4764-17-4

1614

Oxytocics

Phase 2,Not Applicable

Hypnotics and Sedatives

Phase 2

N-Methyl-3,4-methylenedioxyamphetamine

Phase 2

Adrenergic Agents

Phase 2

Hallucinogens

Phase 2

Acetylcysteine

Approved, Investigational

Phase 1

616-91-1

12035

Vitamins

Phase 1

Free Radical Scavengers

Phase 1

Antidotes

Phase 1

Antiviral Agents

Phase 1

N-monoacetylcystine

Phase 1

Expectorants

Phase 1

Antioxidants

Phase 1

Respiratory System Agents

Phase 1

Protective Agents

Phase 1

Hydrocortisone

Approved, Vet_approved

50-23-7

5754

Hydrocortisone acetate

Approved, Vet_approved

50-03-3

Dopamine

Approved

62-31-7, 51-61-6

681

Norepinephrine

Approved

51-41-2

439260

Cocaine

Approved, Illicit

50-36-2

446220 5760

Ethanol

Approved

Not Applicable

64-17-5

702

Interventional clinical trials:

(show top 50) (show all 69)

#	Name	Status	NCT ID	Phase	Drugs
1	D-cycloserine for Relapse Prevention Following Intravenous Ketamine in Treatment-resistant Depression	Unknown status	NCT02772211	Phase 4	Ketamine;D-cycloserine;Placebo
2	Cognitive Behavioral Therapy Versus Sertraline in the Treatment of Post-Traumatic Stress Disorder	Completed	NCT00391430	Phase 4	Sertraline
3	Autism Oxytocin Brain Project	Completed	NCT03033784	Phase 2	Oxytocin;Oxytocin;Oxytocin;Placebo
4	Impact of a Group Intervention on Breast Cancer Patient's Adjustment and Emotion Regulation at the End of Treatment	Completed	NCT01797354	Phase 2
5	Ocytocine and Cerebral Activation in Relation With Attachement	Recruiting	NCT02847143	Phase 2	nasal oxytocin or placebo
6	Effectiveness of BBT-I and Zopiclone for Chronic Insomnia	Completed	NCT03339583	Phase 2	Zopiclone
7	MDMA-assisted Therapy for Social Anxiety in Autistic Adults	Completed	NCT02008396	Phase 2	Placebo;MDMA
8	Pain and Stress Management for Fibromyalgia	Completed	NCT01287481	Phase 2
9	Early Study of N-Acetylcysteine to Treat Deliberate Self-Harm in Adolescents	Completed	NCT01111734	Phase 1	fMRI
10	Neurobiological, Neuropsychological,Linguistic and Gestural Processes and Phenomena in Individuals With Alexithymia	Unknown status	NCT00830752
11	Psychopathological Risk Factors Associated With Conversion From Mild Cognitive Impairment to Dementia	Unknown status	NCT01436552
12	Halifax Treatment Refractory Depression Trial	Unknown status	NCT01141426	Not Applicable
13	Alexithymia Frequency and Interhemispheric Transfer in Patients With a First Demyelinating Event	Completed	NCT03796247
14	Evaluation of Art-therapy on Alexithymia in Patients Suffering From Anorexia Nervosa and From Bulimia	Not yet recruiting	NCT03524443
15	Training to Reconnect With Emotional Awareness Therapy	Recruiting	NCT03414463	Not Applicable
16	The Emotion Builder: An Intervention for Emotional Deficits After Brain Injury	Completed	NCT02432300	Not Applicable
17	Online Treatment of Trichotillomania	Completed	NCT02044237	Not Applicable
18	Clinical Assessment and Psychosocial Impact of Psoriasis	Completed	NCT01964443
19	Psychological Variables and Hyperglycemia in Diabetes Mellitus	Withdrawn	NCT01714986	Not Applicable
20	Asthma, Smoking, Emotional Deficits	Not yet recruiting	NCT03312673
21	Outcomes of Mentalization-Based Treatment for Borderline Personality Disorder	Completed	NCT03295838	Not Applicable
22	Psychological Impact in Diabetes: Intervention With Affect School and Basal Body Awareness	Terminated	NCT01498614	Not Applicable
23	Positive Emotion Regulation Training in Children, Adolescents and Young Adults With and Without Developmental Disorder	Recruiting	NCT02898298	Not Applicable
24	Evaluation of Smell and Taste in Fibromyalgia	Recruiting	NCT03823937
25	Emotion Regulation Group Skills Training for Adolescents and Parents	Recruiting	NCT03900533	Not Applicable
26	Moderating Impact of Various Emotion Personality Factors on Salivary Cortisol Response to a TSST	Completed	NCT00451126
27	Effectiveness of Standard Emergency Department Psychiatric Treatment Associated With Treatment Delivery by a Suicide Prevention Center	Completed	NCT00641498	Not Applicable
28	The Neural Bases of Emotion Regulation in Bulimia Nervosa	Not yet recruiting	NCT03781921
29	Attention Bias Modification Treatment for Warzone-Related Posttraumatic Stress Disorder (PTSD)	Completed	NCT01564667	Not Applicable
30	Service Member Fatigue and Lack of Motivation Following Concussion	Completed	NCT01496586
31	Functional Neuroanatomy and Regional Metabolism Before and After Treatment With Duloxetine	Completed	NCT02658617
32	Development of Reward Processing in Prenatally Exposed Adolescents and Young Adults	Enrolling by invitation	NCT03268759
33	Automated Assessment Using Facial Coding	Not yet recruiting	NCT03551886	Not Applicable
34	Research Project About Psychological Strain, Quality of Life and Emotional Awareness in Patients With Tinnitus	Completed	NCT01837368
35	A SYNdemic BASed INtervention for MSM With High Risk Behavior: Design of a Randomized Controlled Trial	Completed	NCT02859935	Not Applicable
36	Effects of Prenatal Alcohol Exposure on Emotional and Cognitive Abilities in Adults	Active, not recruiting	NCT03793920	Not Applicable
37	Re-nutrition in Severe Anorexia Nervosa	Recruiting	NCT02502617
38	Depression Online Assessment and Therapy	Completed	NCT02112266	Not Applicable
39	Mindfulness in Preparation to Bariatric Surgery	Completed	NCT02854306	Not Applicable
40	CBT-Eb Plus EMDR Versus CBT-Eb in Patients With Eating Disorders	Recruiting	NCT03156959	Not Applicable
41	Childhood Trauma in Schizophrenia: Exploration of Links Between Gene Expression, Cerebral Morphology and Symptomatology	Recruiting	NCT03355781
42	the Effects of Oxytocin on Negative Symptoms and Cognitive Tasks in Schizophrenia and it's Possible Mechanisms.	Not yet recruiting	NCT03662425	Not Applicable	Oxytocin;Saline;Oxytocin;Saline
43	Psychological Predictors in Colorectal Cancer Surgery Recovery	Recruiting	NCT03781193
44	Neuropsychiatric Mechanisms of Change in Mentalization Based Treatment of Borderline Personality Disorder (MENTAB)	Terminated	NCT01720953
45	The Effectiveness of Mindfulness on Chronic Pain in Breast Cancer Survivors	Completed	NCT01674881	Not Applicable
46	Electrophysiological Correlates of Emotional and Crossmodal Stimuli Processing Among Alcohol-dependent Participants	Completed	NCT01633905
47	Emotional Dysregulation in Para-suicidal Behavior	Recruiting	NCT03846375	Not Applicable
48	Extreme Challenges - Psychopathology & Treatment Experiences Among Severly Selfharming Inpatients in Norway	Not yet recruiting	NCT03768674
49	Effects of a Motor Imagery Exercise Protocol in Patients With Fibromyalgia	Completed	NCT03870932	Not Applicable
50	Socio-psychological Factors Involved in the Hematopoietic Stem Cell Transplantation Process in People With Hemopathies	Active, not recruiting	NCT03883672	Not Applicable

Search NIH Clinical Center for Alexithymia

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Genetic Tests for Alexithymia

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Anatomical Context for Alexithymia

MalaCards organs/tissues related to Alexithymia:

⁴²

Brain, Testes, Breast, Heart, Eye, Kidney, Cortex

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Publications for Alexithymia

Articles related to Alexithymia:

(show top 50) (show all 1562)

#	Title	Authors	Year
1	Factorial Validity of the Toronto Alexithymia Scale (TAS-20) in Clinical Samples: A Critical Examination of the Literature and a Psychometric Study in Anorexia Nervosa. ( 29603033 )	Torres S...Rocha M	2019
2	Duration of breastfeeding is associated with emotional eating through its effect on alexithymia in boys, but not girls. ( 30315844 )	van Strien T...Winkens LHH	2019
3	Fearful Attachment Linked to Childhood Abuse, Alexithymia, and Depression in Motor Functional Neurological Disorders. ( 30376786 )	Williams B...Perez DL	2019
4	Investigating alexithymia in autism: A systematic review and meta-analysis. ( 30399531 )	Kinnaird E...Tchanturia K	2019
5	Internet gaming disorder in male and female young adults: The role of alexithymia, depression, anxiety and gaming type. ( 30616119 )	Bonnaire C...Baptista D	2019
6	The role of alexithymia in parent-child interaction and in the emotional ability of children with autism spectrum disorder. ( 30624024 )	Costa AP...V?gele C	2019
7	Alexithymia predicts poorer social and everyday functioning in schizophrenia and bipolar disorder. ( 30658205 )	Ospina LH...Burdick KE	2019
8	Toronto Alexithymia Scale-20: Examining 18 Competing Factor Structure Solutions in a U.S. Sample and a Philippines Sample. ( 30661362 )	Tuliao AP...McChargue DE	2019
9	Evaluation of alexithymia in patients affected by rheumatoid arthritis and psoriatic arthritis: A cross-sectional study. ( 30681555 )	Chimenti MS...Perricone R	2019
10	The role of alexithymia in trauma therapy outcomes: Examining improvements in PTSD, dissociation, and interpersonal problems. ( 30688506 )	Zorzella KPM...Classen CC	2019
11	5-HTTLPR and COMT Val158Met are not associated with alexithymia: New evidence and meta-analyses. ( 30707988 )	Yang Y...Gong P	2019
12	Alexithymia and psoriasis: what is the link? ( 30714112 )	Misery L	2019
13	Alexithymia and frontal-amygdala functional connectivity in North Korean refugees. ( 30744720 )	Kim N...Kim SJ	2019
14	Alexithymia is associated with neural reactivity to masked emotional faces in adolescents who self-harm. ( 30780118 )	Demers LA...Cullen KR	2019
15	The impact of Balint work on alexithymia, perceived stress, perceived social support and burnout among physicians working in palliative care: a longitudinal study. ( 30785127 )	Popa-Velea O...Trutescu C	2019
16	Separate contributions of autistic traits and anxious apprehension, but not alexithymia, to emotion processing in faces. ( 30848668 )	Stephenson KG...South M	2019
17	Parental bonding, adult attachment, and theory of mind: A developmental model of alexithymia and alcohol-related risk. ( 30848836 )	Lyvers M...Thorberg FA	2019
18	Alexithymia Predicts Cognitive Deficits In Patients With Idiopathic Parkinson's Disease. ( 30868777 )	Gul A...Yousaf J	2019
19	Alexithymia Predicts Cognitive Deficits In Patients With Idiopathic Parkinson's Disease. ( 30868778 )	Irfan S...Shaikh A	2019
20	A Comparison Among the Prevalence of Alexithymia in Patients With Psychogenic Nonepileptic Seizures, Epilepsy, and the Healthy Population: A Systematic Review of the Literature. ( 30876655 )	Sequeira AS...Silva B	2019
21	Alexithymia in HIV, HCV and coinfections. ( 30882378 )	Cappabianca A...Santoro R	2019
22	Alexithymia, Suicide Ideation and Homocysteine Levels in Drug Naïve Patients with Major Depression: A Study in the Real World Clinical Practice. ( 30905133 )	Berardis D...Giannantonio MD	2019
23	Does emotion matter? The role of alexithymia in violent recidivism: A systematic literature review. ( 30916846 )	Leshem R...Ben-David BM	2019
24	Alexithymia and weight loss in obese patients underwent laparoscopic sleeve gastrectomy. ( 28353096 )	Paone E...Lai C	2019
25	Attachment avoidance, alexithymia, and gender: Examining their associations with distress disclosure tendencies and event-specific disclosure. ( 29355345 )	O'Loughlin J.I....Wu A.D.	2018
26	Is alexithymia characterised by impaired interoception? Further evidence, the importance of control variables, and the problems with the Heartbeat Counting Task. ( 29803614 )	Murphy J....Bird G.	2018
27	Body talk: Sex differences in the influence of alexithymia on physical complaints among psychiatric outpatients. ( 29309955 )	Ogrodniczuk J.S....Abbass A.A.	2018
28	Affect labeling and other aspects of emotional experiences in relation to alexithymia following standardized emotion inductions. ( 29428774 )	Aaron R.V....Park S.	2018
29	Childhood Trauma and Functional Variants of 5-HTTLPR Are Independently Associated with Alexithymia in 5,283 Subjects from the General Population. ( 29306941 )	Terock J....Grabe H.J.	2018
30	Psychoeducation against depression, anxiety, alexithymia and fibromyalgia: a pilot study in primary care for patients on sick leave. ( 29693478 )	Melin E.O....Thulesius H.O.	2018
31	The functional and structural characteristics of the emotion network in alexithymia. ( 29695908 )	Han D....Sun X.	2018
32	Alexithymia and autistic traits as possible predictors for traits related to depression, anxiety, and stress: A multivariate statistical approach. ( 29882629 )	Fietz J....Silani G.	2018
33	Subjective and Objective: Alexithymia and Social Cognition in Eating Disorders. ( 29916406 )	Hason Rozenstein M....Latzer Y.	2018
34	Psychometric Properties of the Bermond-Vorst Alexithymia Questionnaire (BVAQ) in the General Population and a Clinical Population. ( 29740350 )	de Vroege L....van der Feltz-Cornelis C.M.	2018
35	Association of Internet addiction and alexithymia - A scoping review. ( 29429757 )	Mahapatra A....Sharma P.	2018
36	Alexithymia as a potential source of symptom over-reporting: An exploratory study in forensic patients and non-forensic participants. ( 29349809 )	Merckelbach H....A8 Campo J.	2018
37	Are alexithymia and empathy predicting factors of the resilience of medical residents in France? ( 29731450 )	Morice-Ramat A....Guihard G.	2018
38	Headache and Alexithymia in Children and Adolescents: What Is the Connection? ( 29449820 )	Natalucci G....Guidetti V.	2018
39	Association Between Alexithymia and Functional Gastrointestinal Disorders. ( 29922191 )	Kano M....Fukudo S.	2018
40	Do terrorists suffer from alexithymia? ( 29417660 )	Burns E.J.	2018
41	The influence of alexithymia on mobile phone addiction: The role of depression, anxiety and stress. ( 28926906 )	Gao T....Mei S.	2018
42	Language and alexithymia: Evidence for the role of the inferior frontal gyrus in acquired alexithymia. ( 29360519 )	Hobson H....Grafman J.	2018
43	Alexithymia and Somatosensory Amplification Link Perceived Psychosocial Stress and Somatic Symptoms in Outpatients with Psychosomatic Illness. ( 29748483 )	Nakao M....Takeuchi T.	2018
44	Symptom, alexithymia and self-image outcomes of Mentalisation-based treatment for borderline personality disorder: a naturalistic study. ( 29890960 )	LAPf J....RydAcn G.	2018
45	Assessing advanced theory of mind and alexithymia in patients suffering from enduring borderline personality disorder. ( 29360051 )	Pluta A....Kucharska K.	2018
46	The Relationship Between Alexithymia and Emotional Awareness: A Meta-Analytic Review of the Correlation Between TAS-20 and LEAS. ( 29713295 )	Maroti D....Bileviciute-Ljungar I.	2018
47	Bullying and alexithymia: Are there differences between traditional, cyber, combined bullies, and nonbullies in reading their own emotions? ( 29952143 )	Wachs S....Wright M.F.	2018
48	The Impact of Alexithymia on Emotion Dysregulation in Anorexia Nervosa and Bulimia Nervosa over Time. ( 29266572 )	Brown T.A....Kaye W.H.	2018
49	The relationship between alexithymia and headache impact: the role of somatization and pain catastrophizing. ( 29869297 )	Shim E.J....Park S.P.	2018
50	Influence of anxiety and alexithymia on brain activations associated with the perception of others' pain in autism. ( 29683406 )	Lassalle A....Hadjikhani N.	2018

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Genes for Alexithymia

Genes related to Alexithymia (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ANKK1	Ankyrin Repeat And Kinase Domain Containing 1	Protein Coding	22.87	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	SLC6A4	Solute Carrier Family 6 Member 4	Protein Coding	22.79	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	COMT	Catechol-O-Methyltransferase	Protein Coding	22.11	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	OXTR	Oxytocin Receptor	Protein Coding	21.8	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	DRD2	Dopamine Receptor D2	Protein Coding	21.66	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	TAS2R38	Taste 2 Receptor Member 38	Protein Coding	21.09	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	CRP	C-Reactive Protein	Protein Coding	20.97	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	HTR1A	5-Hydroxytryptamine Receptor 1A	Protein Coding	20.58	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	IL4	Interleukin 4	Protein Coding	20.41	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	IL6	Interleukin 6	Protein Coding	19.97	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

Sources

Variations for Alexithymia

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Expression for Alexithymia

Search GEO for disease gene expression data for Alexithymia.

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Pathways for Alexithymia

Pathways related to Alexithymia according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Selenium Micronutrient Network ¹ Show member pathways Folate Metabolism ¹ Metabolism of ingested MeSeO2H into MeSeH ⁶⁷ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	11.94	CRP IL4 IL6
2	Circadian rythm related genes ¹	11.9	DRD2 IL6 SLC6A4
3	cAMP signaling pathway ³⁸	11.82	DRD2 HTR1A OXTR
4	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	11.34	HTR1A IL6 SLC6A4
5	Development and heterogeneity of the ILC family ¹	10.96	IL4 IL6
6	Cytokines and Inflammatory Response ¹	10.83	IL4 IL6
7	Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics ⁶²	10.7	HTR1A SLC6A4
8	Neurotransmitter Clearance In The Synaptic Cleft ⁶⁷ Show member pathways Dopamine clearance from the synaptic cleft ⁶⁷ Enzymatic degradation of dopamine by COMT ⁶⁷ Enzymatic degradation of Dopamine by monoamine oxidase ⁶⁷ L-dopa degradation ¹ Metabolism of serotonin ⁶⁷ Serotonin clearance from the synaptic cleft ⁶⁷	10.57	COMT SLC6A4
9	Overview of nanoparticle effects ¹	9.9	CRP IL6

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GO Terms for Alexithymia

Biological processes related to Alexithymia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of gene expression	GO:0010628	9.56	CRP IL4 IL6 SLC6A4
2	response to cocaine	GO:0042220	9.46	DRD2 OXTR
3	acute-phase response	GO:0006953	9.43	CRP IL6
4	response to amphetamine	GO:0001975	9.4	DRD2 OXTR
5	vasoconstriction	GO:0042310	9.37	HTR1A SLC6A4
6	dopamine metabolic process	GO:0042417	9.32	COMT DRD2
7	response to drug	GO:0042493	9.26	COMT DRD2 OXTR SLC6A4
8	negative regulation of lipid storage	GO:0010888	9.16	CRP IL6
9	sperm ejaculation	GO:0042713	8.62	OXTR SLC6A4

Molecular functions related to Alexithymia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	serotonin binding	GO:0051378	8.62	HTR1A SLC6A4

Sources

Sources for Alexithymia

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

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