Aliases & Classifications for Alexithymia

MalaCards integrated aliases for Alexithymia:

Name: Alexithymia 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060131

Summaries for Alexithymia

Disease Ontology : 12 An agnosia that is a deficiency in understanding, processing, or describing emotions.

MalaCards based summary : Alexithymia is related to eating disorder and anxiety. An important gene associated with Alexithymia is ANKK1 (Ankyrin Repeat And Kinase Domain Containing 1), and among its related pathways/superpathways are Selenium Micronutrient Network and Circadian rythm related genes. The drugs Cycloserine and Ketamine have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and breast, and related phenotypes are endocrine/exocrine gland and nervous system

Wikipedia : 77 Alexithymia is a personality construct characterized by the subclinical inability to identify and... more...

Related Diseases for Alexithymia

Diseases related to Alexithymia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 251)
# Related Disease Score Top Affiliating Genes
1 eating disorder 31.0 COMT DRD2 SLC6A4
2 anxiety 30.9 COMT HTR1A SLC6A4
3 fibromyalgia 30.6 COMT IL6 SLC6A4
4 traumatic brain injury 30.5 COMT DRD2 IL6
5 brain injury 30.5 COMT DRD2 IL6
6 pathological gambling 30.5 DRD2 SLC6A4
7 panic disorder 30.4 COMT HTR1A SLC6A4
8 somatoform disorder 30.4 COMT IL4
9 post-traumatic stress disorder 30.2 COMT CRP DRD2 SLC6A4
10 borderline personality disorder 30.2 COMT HTR1A SLC6A4
11 inflammatory bowel disease 30.1 CRP IL4 IL6
12 substance abuse 30.0 COMT DRD2 SLC6A4
13 paranoid schizophrenia 30.0 COMT SLC6A4
14 alcohol abuse 29.9 ANKK1 DRD2 SLC6A4
15 mental depression 29.9 COMT HTR1A SLC6A4
16 substance dependence 29.9 DRD2 IL6 SLC6A4
17 personality disorder 29.8 ANKK1 COMT DRD2 HTR1A SLC6A4
18 premature ejaculation 29.6 HTR1A SLC6A4
19 social phobia 29.6 DRD2 HTR1A SLC6A4
20 migraine with or without aura 1 29.6 COMT DRD2 HTR1A SLC6A4
21 obsessive-compulsive disorder 29.6 COMT DRD2 HTR1A OXTR SLC6A4
22 periodontitis 29.5 CRP IL4 IL6
23 intermittent claudication 29.5 CRP IL6
24 generalized anxiety disorder 29.5 COMT DRD2 HTR1A SLC6A4
25 antisocial personality disorder 29.5 ANKK1 COMT DRD2 SLC6A4
26 tobacco addiction 29.4 ANKK1 COMT DRD2 SLC6A4
27 migraine without aura 29.4 DRD2 HTR1A SLC6A4
28 bipolar disorder 29.3 COMT DRD2 HTR1A SLC6A4
29 chronic fatigue syndrome 29.3 COMT HTR1A IL6 SLC6A4
30 alcohol dependence 29.3 ANKK1 COMT DRD2 HTR1A SLC6A4
31 psychotic disorder 29.1 COMT DRD2 HTR1A SLC6A4
32 parkinson disease, late-onset 29.1 COMT DRD2 HTR1A SLC6A4
33 mood disorder 29.0 COMT DRD2 HTR1A IL6 SLC6A4
34 major depressive disorder 29.0 COMT DRD2 HTR1A IL6 OXTR SLC6A4
35 attention deficit-hyperactivity disorder 29.0 ANKK1 COMT DRD2 HTR1A SLC6A4
36 disease of mental health 28.8 COMT DRD2 HTR1A IL6 OXTR SLC6A4
37 social emotional agnosia 11.2
38 depression 10.8
39 autism 10.4
40 alcohol-induced mental disorder 10.4 DRD2 SLC6A4
41 pain - chronic 10.4
42 alcoholic psychosis 10.3 DRD2 SLC6A4
43 schizophreniform disorder 10.3 COMT DRD2
44 polysubstance abuse 10.3 COMT DRD2
45 tardive dyskinesia 10.3 COMT DRD2
46 anorexia nervosa 10.3
47 opioid addiction 10.3 COMT DRD2
48 psoriasis 10.3
49 schizophrenia 10.3
50 impulse control disorder 10.3 ANKK1 DRD2

Graphical network of the top 20 diseases related to Alexithymia:



Diseases related to Alexithymia

Symptoms & Phenotypes for Alexithymia

MGI Mouse Phenotypes related to Alexithymia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.43 COMT DRD2 IL4 IL6 OXTR SLC6A4
2 nervous system MP:0003631 9.17 COMT DRD2 HTR1A IL4 IL6 OXTR

Drugs & Therapeutics for Alexithymia

Drugs for Alexithymia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 72)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cycloserine Approved Phase 4 68-41-7 6234 401
2
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
3
Sertraline Approved Phase 4 79617-96-2 68617
4 Anesthetics, Intravenous Phase 4
5 Excitatory Amino Acids Phase 4
6 Anti-Bacterial Agents Phase 4
7 Antimetabolites Phase 4
8 Antibiotics, Antitubercular Phase 4
9 Antidepressive Agents Phase 4
10 Anti-Infective Agents Phase 4,Phase 1,Not Applicable
11 Anesthetics, Dissociative Phase 4
12 Central Nervous System Depressants Phase 4,Phase 2,Not Applicable
13 Antitubercular Agents Phase 4
14 Excitatory Amino Acid Antagonists Phase 4
15 Anesthetics, General Phase 4
16 Anti-Infective Agents, Urinary Phase 4
17 Anesthetics Phase 4
18 Analgesics Phase 4
19 Neurotransmitter Agents Phase 4,Phase 2
20 Renal Agents Phase 4
21 Peripheral Nervous System Agents Phase 4
22 Serotonin Uptake Inhibitors Phase 4
23 Serotonin Agents Phase 4,Phase 2
24 Psychotropic Drugs Phase 4,Phase 2,Not Applicable
25 Neurotransmitter Uptake Inhibitors Phase 4,Phase 2
26
Serotonin Investigational, Nutraceutical Phase 4,Phase 2 50-67-9 5202
27
Oxytocin Approved, Vet_approved Phase 2,Not Applicable 50-56-6 53477758 439302
28
Zopiclone Approved Phase 2 43200-80-2 5735
29
3,4-Methylenedioxyamphetamine Experimental, Illicit Phase 2 4764-17-4 1614
30 Oxytocics Phase 2,Not Applicable
31 Hypnotics and Sedatives Phase 2
32 Adrenergic Agents Phase 2
33 N-Methyl-3,4-methylenedioxyamphetamine Phase 2
34 Hallucinogens Phase 2
35
Acetylcysteine Approved, Investigational Phase 1 616-91-1 12035
36 N-monoacetylcystine Phase 1
37 Free Radical Scavengers Phase 1
38 Antiviral Agents Phase 1
39 Antidotes Phase 1
40 Vitamins Phase 1
41 Expectorants Phase 1
42 Respiratory System Agents Phase 1
43 Antioxidants Phase 1
44 Protective Agents Phase 1
45
Hydrocortisone Approved, Vet_approved 50-23-7 5754
46
Hydrocortisone acetate Approved, Vet_approved 50-03-3
47
Dopamine Approved 62-31-7, 51-61-6 681
48
Norepinephrine Approved 51-41-2 439260
49
Ethanol Approved ,Not Applicable 64-17-5 702
50
Zinc oxide Approved Not Applicable 1314-13-2

Interventional clinical trials:

(show top 50) (show all 69)
# Name Status NCT ID Phase Drugs
1 D-cycloserine for Relapse Prevention Following Intravenous Ketamine in Treatment-resistant Depression Unknown status NCT02772211 Phase 4 Ketamine;D-cycloserine;Placebo
2 Cognitive Behavioral Therapy Versus Sertraline in the Treatment of Post-Traumatic Stress Disorder Completed NCT00391430 Phase 4 Sertraline
3 Autism Oxytocin Brain Project Completed NCT03033784 Phase 2 Oxytocin;Oxytocin;Oxytocin;Placebo
4 Impact of a Group Intervention on Breast Cancer Patient's Adjustment and Emotion Regulation at the End of Treatment Completed NCT01797354 Phase 2
5 Effectiveness of BBT-I and Zopiclone for Chronic Insomnia Completed NCT03339583 Phase 2 Zopiclone
6 MDMA-assisted Therapy for Social Anxiety in Autistic Adults Completed NCT02008396 Phase 2 Placebo;MDMA
7 Pain and Stress Management for Fibromyalgia Completed NCT01287481 Phase 2
8 Ocytocine and Cerebral Activation in Relation With Attachement Recruiting NCT02847143 Phase 2 nasal oxytocin or placebo
9 Early Study of N-Acetylcysteine to Treat Deliberate Self-Harm in Adolescents Completed NCT01111734 Phase 1 fMRI
10 Neurobiological, Neuropsychological,Linguistic and Gestural Processes and Phenomena in Individuals With Alexithymia Unknown status NCT00830752
11 Psychopathological Risk Factors Associated With Conversion From Mild Cognitive Impairment to Dementia Unknown status NCT01436552
12 Halifax Treatment Refractory Depression Trial Unknown status NCT01141426 Not Applicable
13 Alexithymia Frequency and Interhemispheric Transfer in Patients With a First Demyelinating Event Completed NCT03796247
14 The Emotion Builder: An Intervention for Emotional Deficits After Brain Injury Completed NCT02432300 Not Applicable
15 Online Treatment of Trichotillomania Completed NCT02044237 Not Applicable
16 Clinical Assessment and Psychosocial Impact of Psoriasis Completed NCT01964443
17 Outcomes of Mentalization-Based Treatment for Borderline Personality Disorder Completed NCT03295838 Not Applicable
18 Moderating Impact of Various Emotion Personality Factors on Salivary Cortisol Response to a TSST Completed NCT00451126
19 Effectiveness of Standard Emergency Department Psychiatric Treatment Associated With Treatment Delivery by a Suicide Prevention Center Completed NCT00641498 Not Applicable
20 Attention Bias Modification Treatment for Warzone-Related Posttraumatic Stress Disorder (PTSD) Completed NCT01564667 Not Applicable
21 Service Member Fatigue and Lack of Motivation Following Concussion Completed NCT01496586
22 Functional Neuroanatomy and Regional Metabolism Before and After Treatment With Duloxetine Completed NCT02658617
23 Research Project About Psychological Strain, Quality of Life and Emotional Awareness in Patients With Tinnitus Completed NCT01837368
24 A SYNdemic BASed INtervention for MSM With High Risk Behavior: Design of a Randomized Controlled Trial Completed NCT02859935 Not Applicable
25 Depression Online Assessment and Therapy Completed NCT02112266 Not Applicable
26 Mindfulness in Preparation to Bariatric Surgery Completed NCT02854306 Not Applicable
27 The Effectiveness of Mindfulness on Chronic Pain in Breast Cancer Survivors Completed NCT01674881 Not Applicable
28 Electrophysiological Correlates of Emotional and Crossmodal Stimuli Processing Among Alcohol-dependent Participants Completed NCT01633905
29 Effects of a Motor Imagery Exercise Protocol in Patients With Fibromyalgia Completed NCT03870932 Not Applicable
30 Plasticity of the Compassionate Brain Completed NCT01833104 Not Applicable
31 Oculomotor Markers and Attachment in Adolescents Completed NCT02851810 Not Applicable
32 Stress Management for Irritable Bowel Syndrome Completed NCT01886027 Not Applicable
33 Mindfulness for Irritable Bowel Syndrome Completed NCT02794376 Not Applicable
34 Improving Happiness in Flanders Completed NCT02041741 Not Applicable
35 Chronic Low Back Pain: A Multidisciplinary Approach Completed NCT01993355 Not Applicable
36 Training to Reconnect With Emotional Awareness Therapy Recruiting NCT03414463 Not Applicable
37 Positive Emotion Regulation Training in Children, Adolescents and Young Adults With and Without Developmental Disorder Recruiting NCT02898298 Not Applicable
38 Evaluation of Smell and Taste in Fibromyalgia Recruiting NCT03823937
39 Emotion Regulation Group Skills Training for Adolescents and Parents Recruiting NCT03900533 Not Applicable
40 Re-nutrition in Severe Anorexia Nervosa Recruiting NCT02502617
41 CBT-Eb Plus EMDR Versus CBT-Eb in Patients With Eating Disorders Recruiting NCT03156959 Not Applicable
42 Childhood Trauma in Schizophrenia: Exploration of Links Between Gene Expression, Cerebral Morphology and Symptomatology Recruiting NCT03355781
43 Psychological Predictors in Colorectal Cancer Surgery Recovery Recruiting NCT03781193
44 Emotional Dysregulation in Para-suicidal Behavior Recruiting NCT03846375 Not Applicable
45 Influence of Main Psychological and Social Factors on Primary Headaches Recruiting NCT03577548
46 Student Outcomes of Integrative Mental Health Services Recruiting NCT02877875 Not Applicable
47 Olfactory Training and Emotional State Recruiting NCT03605524 Not Applicable
48 Estradiol-mediated Neural Plasticity as Potential Mediator of Neurofeedback Treatment Change for Traumatized Women Recruiting NCT03416764 Not Applicable
49 Can Cognitive Training Decrease Reactive Aggression? Recruiting NCT03623477 Not Applicable
50 Family Therapy and Anorexia Nervosa : Which is the Best Approach? Recruiting NCT03350594 Not Applicable

Search NIH Clinical Center for Alexithymia

Genetic Tests for Alexithymia

Anatomical Context for Alexithymia

MalaCards organs/tissues related to Alexithymia:

42
Brain, Heart, Breast, Testes, Skin, Eye, T Cells

Publications for Alexithymia

Articles related to Alexithymia:

(show top 50) (show all 1577)
# Title Authors Year
1
Fearful Attachment Linked to Childhood Abuse, Alexithymia, and Depression in Motor Functional Neurological Disorders. ( 30376786 )
2019
2
Is it the Taste or the Buzz? Alexithymia, Caffeine, and Emotional Eating. ( 30380968 )
2019
3
Investigating alexithymia in autism: A systematic review and meta-analysis. ( 30399531 )
2019
4
Alcohol and tobacco use in men: the role of alexithymia and externally oriented thinking style. ( 30427739 )
2019
5
Factors related to alexithymia in patients with systemic sclerosis: a tight relationship with facial image dissatisfaction. ( 30498976 )
2019
6
Posttraumatic Stress and Interpersonal Sensitivity: Alexithymia as Mediator and Emotional Expressivity as Moderator. ( 30515699 )
2019
7
Internet gaming disorder in male and female young adults: The role of alexithymia, depression, anxiety and gaming type. ( 30616119 )
2019
8
The Role of Alexithymia in Parent-Child Interaction and in the Emotional Ability of Children with Autism Spectrum Disorder. ( 30624024 )
2019
9
Alexithymia predicts poorer social and everyday functioning in schizophrenia and bipolar disorder. ( 30658205 )
2019
10
Toronto Alexithymia Scale-20: Examining 18 Competing Factor Structure Solutions in a U.S. Sample and a Philippines Sample. ( 30661362 )
2019
11
Evaluation of alexithymia in patients affected by rheumatoid arthritis and psoriatic arthritis: A cross-sectional study. ( 30681555 )
2019
12
The role of alexithymia in trauma therapy outcomes: Examining improvements in PTSD, dissociation, and interpersonal problems. ( 30688506 )
2019
13
5-HTTLPR and COMT Val158Met are not associated with alexithymia: New evidence and meta-analyses. ( 30707988 )
2019
14
Alexithymia and psoriasis: what is the link? ( 30714112 )
2019
15
Alexithymia and frontal-amygdala functional connectivity in North Korean refugees. ( 30744720 )
2019
16
Alexithymia is associated with neural reactivity to masked emotional faces in adolescents who self-harm. ( 30780118 )
2019
17
The impact of Balint work on alexithymia, perceived stress, perceived social support and burnout among physicians working in palliative care: a longitudinal study. ( 30785127 )
2019
18
Separate contributions of autistic traits and anxious apprehension, but not alexithymia, to emotion processing in faces. ( 30848668 )
2019
19
Parental bonding, adult attachment, and theory of mind: A developmental model of alexithymia and alcohol-related risk. ( 30848836 )
2019
20
Alexithymia Predicts Cognitive Deficits In Patients With Idiopathic Parkinson's Disease. ( 30868777 )
2019
21
Alexithymia Predicts Cognitive Deficits In Patients With Idiopathic Parkinson's Disease. ( 30868778 )
2019
22
A Comparison Among the Prevalence of Alexithymia in Patients With Psychogenic Nonepileptic Seizures, Epilepsy, and the Healthy Population: A Systematic Review of the Literature. ( 30876655 )
2019
23
Alexithymia in HIV, HCV and coinfections. ( 30882378 )
2019
24
Alexithymia, Suicide Ideation and Homocysteine Levels in Drug Naïve Patients with Major Depression: A Study in the "Real World" Clinical Practice ( 30905133 )
2019
25
Does emotion matter? The role of alexithymia in violent recidivism: A systematic literature review. ( 30916846 )
2019
26
A mediational model linking perceptions of security, alexithymia and behavior problems of sexually abused children. ( 30933832 )
2019
27
Transdiagnostic mechanisms involved in nonsuicidal self-injury, risky drinking and disordered eating: Impulsivity, emotion regulation and alexithymia. ( 30939103 )
2019
28
The Relationship Between Parental Attachment and Mobile Phone Dependence Among Chinese Rural Adolescents: The Role of Alexithymia and Mindfulness. ( 30949104 )
2019
29
Shame and guilt mediate the effects of alexithymia on distress and suicide-related behaviours among men. ( 30950285 )
2019
30
Prevalence of alexithymia in eating disorders in a clinical sample of 800 Mexican patients. ( 30951037 )
2019
31
Emotional intelligence, empathy and alexithymia: a cross-sectional survey on emotional competence in a group of nursing students. ( 30977747 )
2019
32
The role of long-term psychodynamic psychotherapy in improving attachment patterns, defense styles, and alexithymia in patients with depressive/anxiety disorders. ( 30994785 )
2019
33
Factors associated with the adults' attachment styles in Lebanon: The role of alexithymia, depression, anxiety, stress, burnout, and emotional intelligence. ( 31004358 )
2019
34
Alexithymia in individuals with chronic pain and its relation to pain intensity, physical interference, depression, and anxiety: a systematic review and meta-analysis. ( 31009416 )
2019
35
Alexithymia moderates effects of psychotherapeutic treatment expectations on depression outcome in interdisciplinary chronic pain treatment. ( 31010581 )
2019
36
Interoceptive awareness, alexithymia, and sexual function. ( 31018783 )
2019
37
Mood Disorders in High-Functioning Autism: The Importance of Alexithymia and Emotional Regulation. ( 31028592 )
2019
38
Alexithymia and Its Associations With Depression, Suicidality, and Aggression: An Overview of the Literature. ( 31031655 )
2019
39
Psychometric properties of the Toronto Alexithymia Scale (TAS-20) in Brazil. ( 31067154 )
2019
40
Memory for emotional information and alexithymia A systematic review. ( 31073377 )
2019
41
The relationship between levels of Alexithymia and communication skills of nursing students. ( 31086538 )
2019
42
A systematic review and meta-analysis of the association between alexithymia and suicide ideation and behaviour. ( 31103905 )
2019
43
Smartphone-based emotion recognition skills training for alexithymia - A randomized controlled pilot study. ( 31110950 )
2019
44
Factorial Validity of the Toronto Alexithymia Scale (TAS-20) in Clinical Samples: A Critical Examination of the Literature and a Psychometric Study in Anorexia Nervosa. ( 29603033 )
2019
45
Influence of anxiety and alexithymia on brain activations associated with the perception of others' pain in autism. ( 29683406 )
2019
46
Alexithymia and tic disorders: a study on a sample of children and their mothers. ( 30056587 )
2019
47
Effects of mindfulness-based interventions on alexithymia: a systematic review. ( 30077988 )
2019
48
Beneficial effects of bilateral subthalamic stimulation on alexithymia in Parkinson's disease. ( 30107062 )
2019
49
Reversibility of alexithymia with effective treatment of moderate-to-severe psoriasis: longitudinal data from EPIDEPSO. ( 30269346 )
2019
50
The development and evaluation of a brief form of the Normative Male Alexithymia Scale (NMAS-BF). ( 30284847 )
2019

Variations for Alexithymia

Expression for Alexithymia

Search GEO for disease gene expression data for Alexithymia.

Pathways for Alexithymia

GO Terms for Alexithymia

Biological processes related to Alexithymia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.56 CRP IL4 IL6 SLC6A4
2 response to cocaine GO:0042220 9.46 DRD2 OXTR
3 acute-phase response GO:0006953 9.43 CRP IL6
4 response to amphetamine GO:0001975 9.4 DRD2 OXTR
5 vasoconstriction GO:0042310 9.37 HTR1A SLC6A4
6 dopamine metabolic process GO:0042417 9.32 COMT DRD2
7 response to drug GO:0042493 9.26 COMT DRD2 OXTR SLC6A4
8 negative regulation of lipid storage GO:0010888 9.16 CRP IL6
9 sperm ejaculation GO:0042713 8.62 OXTR SLC6A4

Molecular functions related to Alexithymia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serotonin binding GO:0051378 8.62 HTR1A SLC6A4

Sources for Alexithymia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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