Alexithymia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ALX002 MIFTS: 43	Alexithymia Categories: Mental diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Alexithymia

MalaCards integrated aliases for Alexithymia:

Name: Alexithymia ¹² ¹⁵

Classifications:

MalaCards categories:
Anatomical: Mental diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060131

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Summaries for Alexithymia

Disease Ontology : ¹² An agnosia that is a deficiency in understanding, processing, or describing emotions.

MalaCards based summary : Alexithymia is related to eating disorder and anxiety. An important gene associated with Alexithymia is ANKK1 (Ankyrin Repeat And Kinase Domain Containing 1), and among its related pathways/superpathways are Selenium Micronutrient Network and Circadian rythm related genes. The drugs Cycloserine and Ketamine have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and breast, and related phenotypes are endocrine/exocrine gland and nervous system

Wikipedia : ⁷⁷ Alexithymia is a personality construct characterized by the subclinical inability to identify and... more...

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Related Diseases for Alexithymia

Diseases related to Alexithymia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 251)

#	Related Disease	Score	Top Affiliating Genes
1	eating disorder	31.0	COMT DRD2 SLC6A4
2	anxiety	30.9	COMT HTR1A SLC6A4
3	fibromyalgia	30.6	COMT IL6 SLC6A4
4	traumatic brain injury	30.5	COMT DRD2 IL6
5	brain injury	30.5	COMT DRD2 IL6
6	pathological gambling	30.5	DRD2 SLC6A4
7	panic disorder	30.4	COMT HTR1A SLC6A4
8	somatoform disorder	30.4	COMT IL4
9	post-traumatic stress disorder	30.2	COMT CRP DRD2 SLC6A4
10	borderline personality disorder	30.2	COMT HTR1A SLC6A4
11	inflammatory bowel disease	30.1	CRP IL4 IL6
12	substance abuse	30.0	COMT DRD2 SLC6A4
13	paranoid schizophrenia	30.0	COMT SLC6A4
14	alcohol abuse	29.9	ANKK1 DRD2 SLC6A4
15	mental depression	29.9	COMT HTR1A SLC6A4
16	substance dependence	29.9	DRD2 IL6 SLC6A4
17	personality disorder	29.8	ANKK1 COMT DRD2 HTR1A SLC6A4
18	premature ejaculation	29.6	HTR1A SLC6A4
19	social phobia	29.6	DRD2 HTR1A SLC6A4
20	migraine with or without aura 1	29.6	COMT DRD2 HTR1A SLC6A4
21	obsessive-compulsive disorder	29.6	COMT DRD2 HTR1A OXTR SLC6A4
22	periodontitis	29.5	CRP IL4 IL6
23	intermittent claudication	29.5	CRP IL6
24	generalized anxiety disorder	29.5	COMT DRD2 HTR1A SLC6A4
25	antisocial personality disorder	29.5	ANKK1 COMT DRD2 SLC6A4
26	tobacco addiction	29.4	ANKK1 COMT DRD2 SLC6A4
27	migraine without aura	29.4	DRD2 HTR1A SLC6A4
28	bipolar disorder	29.3	COMT DRD2 HTR1A SLC6A4
29	chronic fatigue syndrome	29.3	COMT HTR1A IL6 SLC6A4
30	alcohol dependence	29.3	ANKK1 COMT DRD2 HTR1A SLC6A4
31	psychotic disorder	29.1	COMT DRD2 HTR1A SLC6A4
32	parkinson disease, late-onset	29.1	COMT DRD2 HTR1A SLC6A4
33	mood disorder	29.0	COMT DRD2 HTR1A IL6 SLC6A4
34	major depressive disorder	29.0	COMT DRD2 HTR1A IL6 OXTR SLC6A4
35	attention deficit-hyperactivity disorder	29.0	ANKK1 COMT DRD2 HTR1A SLC6A4
36	disease of mental health	28.8	COMT DRD2 HTR1A IL6 OXTR SLC6A4
37	social emotional agnosia	11.2
38	depression	10.8
39	autism	10.4
40	alcohol-induced mental disorder	10.4	DRD2 SLC6A4
41	pain - chronic	10.4
42	alcoholic psychosis	10.3	DRD2 SLC6A4
43	schizophreniform disorder	10.3	COMT DRD2
44	polysubstance abuse	10.3	COMT DRD2
45	tardive dyskinesia	10.3	COMT DRD2
46	anorexia nervosa	10.3
47	opioid addiction	10.3	COMT DRD2
48	psoriasis	10.3
49	schizophrenia	10.3
50	impulse control disorder	10.3	ANKK1 DRD2

Graphical network of the top 20 diseases related to Alexithymia:

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Symptoms & Phenotypes for Alexithymia

MGI Mouse Phenotypes related to Alexithymia:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland	MP:0005379	9.43	COMT DRD2 IL4 IL6 OXTR SLC6A4
2	nervous system	MP:0003631	9.17	COMT DRD2 HTR1A IL4 IL6 OXTR

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Drugs & Therapeutics for Alexithymia

Drugs for Alexithymia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 72)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Cycloserine

Approved

Phase 4

68-41-7

6234 401

Ketamine

Approved, Vet_approved

Phase 4

6740-88-1

3821

Sertraline

Approved

Phase 4

79617-96-2

68617

Anesthetics, Intravenous

Phase 4

Excitatory Amino Acids

Phase 4

Anti-Bacterial Agents

Phase 4

Antimetabolites

Phase 4

Antibiotics, Antitubercular

Phase 4

Antidepressive Agents

Phase 4

Anti-Infective Agents

Phase 4,Phase 1,Not Applicable

Anesthetics, Dissociative

Phase 4

Central Nervous System Depressants

Phase 4,Phase 2,Not Applicable

Antitubercular Agents

Phase 4

Excitatory Amino Acid Antagonists

Phase 4

Anesthetics, General

Phase 4

Anti-Infective Agents, Urinary

Phase 4

Anesthetics

Phase 4

Analgesics

Phase 4

Neurotransmitter Agents

Phase 4,Phase 2

Renal Agents

Phase 4

Peripheral Nervous System Agents

Phase 4

Serotonin Uptake Inhibitors

Phase 4

Serotonin Agents

Phase 4,Phase 2

Psychotropic Drugs

Phase 4,Phase 2,Not Applicable

Neurotransmitter Uptake Inhibitors

Phase 4,Phase 2

Serotonin

Investigational, Nutraceutical

Phase 4,Phase 2

50-67-9

5202

Oxytocin

Approved, Vet_approved

Phase 2,Not Applicable

50-56-6

53477758 439302

Zopiclone

Approved

Phase 2

43200-80-2

5735

3,4-Methylenedioxyamphetamine

Experimental, Illicit

Phase 2

4764-17-4

1614

Oxytocics

Phase 2,Not Applicable

Hypnotics and Sedatives

Phase 2

Adrenergic Agents

Phase 2

N-Methyl-3,4-methylenedioxyamphetamine

Phase 2

Hallucinogens

Phase 2

Acetylcysteine

Approved, Investigational

Phase 1

616-91-1

12035

N-monoacetylcystine

Phase 1

Free Radical Scavengers

Phase 1

Antiviral Agents

Phase 1

Antidotes

Phase 1

Vitamins

Phase 1

Expectorants

Phase 1

Respiratory System Agents

Phase 1

Antioxidants

Phase 1

Protective Agents

Phase 1

Hydrocortisone

Approved, Vet_approved

50-23-7

5754

Hydrocortisone acetate

Approved, Vet_approved

50-03-3

Dopamine

Approved

62-31-7, 51-61-6

681

Norepinephrine

Approved

51-41-2

439260

Ethanol

Approved

,Not Applicable

64-17-5

702

Zinc oxide

Approved

Not Applicable

1314-13-2

Interventional clinical trials:

(show top 50) (show all 69)

#	Name	Status	NCT ID	Phase	Drugs
1	D-cycloserine for Relapse Prevention Following Intravenous Ketamine in Treatment-resistant Depression	Unknown status	NCT02772211	Phase 4	Ketamine;D-cycloserine;Placebo
2	Cognitive Behavioral Therapy Versus Sertraline in the Treatment of Post-Traumatic Stress Disorder	Completed	NCT00391430	Phase 4	Sertraline
3	Autism Oxytocin Brain Project	Completed	NCT03033784	Phase 2	Oxytocin;Oxytocin;Oxytocin;Placebo
4	Impact of a Group Intervention on Breast Cancer Patient's Adjustment and Emotion Regulation at the End of Treatment	Completed	NCT01797354	Phase 2
5	Effectiveness of BBT-I and Zopiclone for Chronic Insomnia	Completed	NCT03339583	Phase 2	Zopiclone
6	MDMA-assisted Therapy for Social Anxiety in Autistic Adults	Completed	NCT02008396	Phase 2	Placebo;MDMA
7	Pain and Stress Management for Fibromyalgia	Completed	NCT01287481	Phase 2
8	Ocytocine and Cerebral Activation in Relation With Attachement	Recruiting	NCT02847143	Phase 2	nasal oxytocin or placebo
9	Early Study of N-Acetylcysteine to Treat Deliberate Self-Harm in Adolescents	Completed	NCT01111734	Phase 1	fMRI
10	Neurobiological, Neuropsychological,Linguistic and Gestural Processes and Phenomena in Individuals With Alexithymia	Unknown status	NCT00830752
11	Psychopathological Risk Factors Associated With Conversion From Mild Cognitive Impairment to Dementia	Unknown status	NCT01436552
12	Halifax Treatment Refractory Depression Trial	Unknown status	NCT01141426	Not Applicable
13	Alexithymia Frequency and Interhemispheric Transfer in Patients With a First Demyelinating Event	Completed	NCT03796247
14	The Emotion Builder: An Intervention for Emotional Deficits After Brain Injury	Completed	NCT02432300	Not Applicable
15	Online Treatment of Trichotillomania	Completed	NCT02044237	Not Applicable
16	Clinical Assessment and Psychosocial Impact of Psoriasis	Completed	NCT01964443
17	Outcomes of Mentalization-Based Treatment for Borderline Personality Disorder	Completed	NCT03295838	Not Applicable
18	Moderating Impact of Various Emotion Personality Factors on Salivary Cortisol Response to a TSST	Completed	NCT00451126
19	Effectiveness of Standard Emergency Department Psychiatric Treatment Associated With Treatment Delivery by a Suicide Prevention Center	Completed	NCT00641498	Not Applicable
20	Attention Bias Modification Treatment for Warzone-Related Posttraumatic Stress Disorder (PTSD)	Completed	NCT01564667	Not Applicable
21	Service Member Fatigue and Lack of Motivation Following Concussion	Completed	NCT01496586
22	Functional Neuroanatomy and Regional Metabolism Before and After Treatment With Duloxetine	Completed	NCT02658617
23	Research Project About Psychological Strain, Quality of Life and Emotional Awareness in Patients With Tinnitus	Completed	NCT01837368
24	A SYNdemic BASed INtervention for MSM With High Risk Behavior: Design of a Randomized Controlled Trial	Completed	NCT02859935	Not Applicable
25	Depression Online Assessment and Therapy	Completed	NCT02112266	Not Applicable
26	Mindfulness in Preparation to Bariatric Surgery	Completed	NCT02854306	Not Applicable
27	The Effectiveness of Mindfulness on Chronic Pain in Breast Cancer Survivors	Completed	NCT01674881	Not Applicable
28	Electrophysiological Correlates of Emotional and Crossmodal Stimuli Processing Among Alcohol-dependent Participants	Completed	NCT01633905
29	Effects of a Motor Imagery Exercise Protocol in Patients With Fibromyalgia	Completed	NCT03870932	Not Applicable
30	Plasticity of the Compassionate Brain	Completed	NCT01833104	Not Applicable
31	Oculomotor Markers and Attachment in Adolescents	Completed	NCT02851810	Not Applicable
32	Stress Management for Irritable Bowel Syndrome	Completed	NCT01886027	Not Applicable
33	Mindfulness for Irritable Bowel Syndrome	Completed	NCT02794376	Not Applicable
34	Improving Happiness in Flanders	Completed	NCT02041741	Not Applicable
35	Chronic Low Back Pain: A Multidisciplinary Approach	Completed	NCT01993355	Not Applicable
36	Training to Reconnect With Emotional Awareness Therapy	Recruiting	NCT03414463	Not Applicable
37	Positive Emotion Regulation Training in Children, Adolescents and Young Adults With and Without Developmental Disorder	Recruiting	NCT02898298	Not Applicable
38	Evaluation of Smell and Taste in Fibromyalgia	Recruiting	NCT03823937
39	Emotion Regulation Group Skills Training for Adolescents and Parents	Recruiting	NCT03900533	Not Applicable
40	Re-nutrition in Severe Anorexia Nervosa	Recruiting	NCT02502617
41	CBT-Eb Plus EMDR Versus CBT-Eb in Patients With Eating Disorders	Recruiting	NCT03156959	Not Applicable
42	Childhood Trauma in Schizophrenia: Exploration of Links Between Gene Expression, Cerebral Morphology and Symptomatology	Recruiting	NCT03355781
43	Psychological Predictors in Colorectal Cancer Surgery Recovery	Recruiting	NCT03781193
44	Emotional Dysregulation in Para-suicidal Behavior	Recruiting	NCT03846375	Not Applicable
45	Influence of Main Psychological and Social Factors on Primary Headaches	Recruiting	NCT03577548
46	Student Outcomes of Integrative Mental Health Services	Recruiting	NCT02877875	Not Applicable
47	Olfactory Training and Emotional State	Recruiting	NCT03605524	Not Applicable
48	Estradiol-mediated Neural Plasticity as Potential Mediator of Neurofeedback Treatment Change for Traumatized Women	Recruiting	NCT03416764	Not Applicable
49	Can Cognitive Training Decrease Reactive Aggression?	Recruiting	NCT03623477	Not Applicable
50	Family Therapy and Anorexia Nervosa : Which is the Best Approach?	Recruiting	NCT03350594	Not Applicable

Search NIH Clinical Center for Alexithymia

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Genetic Tests for Alexithymia

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Anatomical Context for Alexithymia

MalaCards organs/tissues related to Alexithymia:

⁴²

Brain, Heart, Breast, Testes, Skin, Eye, T Cells

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Publications for Alexithymia

Articles related to Alexithymia:

(show top 50) (show all 1577)

#	Title	Authors	Year
1	Fearful Attachment Linked to Childhood Abuse, Alexithymia, and Depression in Motor Functional Neurological Disorders. ( 30376786 )	Williams B...Perez DL	2019
2	Is it the Taste or the Buzz? Alexithymia, Caffeine, and Emotional Eating. ( 30380968 )	Lyvers M...Thorberg FA	2019
3	Investigating alexithymia in autism: A systematic review and meta-analysis. ( 30399531 )	Kinnaird E...Tchanturia K	2019
4	Alcohol and tobacco use in men: the role of alexithymia and externally oriented thinking style. ( 30427739 )	Kajanoja J...Karlsson H	2019
5	Factors related to alexithymia in patients with systemic sclerosis: a tight relationship with facial image dissatisfaction. ( 30498976 )	Basta F...Afeltra A	2019
6	Posttraumatic Stress and Interpersonal Sensitivity: Alexithymia as Mediator and Emotional Expressivity as Moderator. ( 30515699 )	Slanbekova GK...Alimbayeva RT	2019
7	Internet gaming disorder in male and female young adults: The role of alexithymia, depression, anxiety and gaming type. ( 30616119 )	Bonnaire C...Baptista D	2019
8	The Role of Alexithymia in Parent-Child Interaction and in the Emotional Ability of Children with Autism Spectrum Disorder. ( 30624024 )	Costa AP...V?gele C	2019
9	Alexithymia predicts poorer social and everyday functioning in schizophrenia and bipolar disorder. ( 30658205 )	Ospina LH...Burdick KE	2019
10	Toronto Alexithymia Scale-20: Examining 18 Competing Factor Structure Solutions in a U.S. Sample and a Philippines Sample. ( 30661362 )	Tuliao AP...McChargue DE	2019
11	Evaluation of alexithymia in patients affected by rheumatoid arthritis and psoriatic arthritis: A cross-sectional study. ( 30681555 )	Chimenti MS...Perricone R	2019
12	The role of alexithymia in trauma therapy outcomes: Examining improvements in PTSD, dissociation, and interpersonal problems. ( 30688506 )	Zorzella KPM...Classen CC	2019
13	5-HTTLPR and COMT Val158Met are not associated with alexithymia: New evidence and meta-analyses. ( 30707988 )	Yang Y...Gong P	2019
14	Alexithymia and psoriasis: what is the link? ( 30714112 )	Misery L	2019
15	Alexithymia and frontal-amygdala functional connectivity in North Korean refugees. ( 30744720 )	Kim N...Kim SJ	2019
16	Alexithymia is associated with neural reactivity to masked emotional faces in adolescents who self-harm. ( 30780118 )	Demers LA...Cullen KR	2019
17	The impact of Balint work on alexithymia, perceived stress, perceived social support and burnout among physicians working in palliative care: a longitudinal study. ( 30785127 )	Popa-Velea O...Trutescu C	2019
18	Separate contributions of autistic traits and anxious apprehension, but not alexithymia, to emotion processing in faces. ( 30848668 )	Stephenson KG...South M	2019
19	Parental bonding, adult attachment, and theory of mind: A developmental model of alexithymia and alcohol-related risk. ( 30848836 )	Lyvers M...Thorberg FA	2019
20	Alexithymia Predicts Cognitive Deficits In Patients With Idiopathic Parkinson's Disease. ( 30868777 )	Gul A...Yousaf J	2019
21	Alexithymia Predicts Cognitive Deficits In Patients With Idiopathic Parkinson's Disease. ( 30868778 )	Irfan S...Shaikh A	2019
22	A Comparison Among the Prevalence of Alexithymia in Patients With Psychogenic Nonepileptic Seizures, Epilepsy, and the Healthy Population: A Systematic Review of the Literature. ( 30876655 )	Sequeira AS...Silva B	2019
23	Alexithymia in HIV, HCV and coinfections. ( 30882378 )	Cappabianca A...Santoro R	2019
24	Alexithymia, Suicide Ideation and Homocysteine Levels in Drug Naïve Patients with Major Depression: A Study in the "Real World" Clinical Practice ( 30905133 )	De Berardis D...Di Giannantonio M	2019
25	Does emotion matter? The role of alexithymia in violent recidivism: A systematic literature review. ( 30916846 )	Leshem R...Ben-David BM	2019
26	A mediational model linking perceptions of security, alexithymia and behavior problems of sexually abused children. ( 30933832 )	Boisjoli C...Caron PO	2019
27	Transdiagnostic mechanisms involved in nonsuicidal self-injury, risky drinking and disordered eating: Impulsivity, emotion regulation and alexithymia. ( 30939103 )	Hasking P...Claes L	2019
28	The Relationship Between Parental Attachment and Mobile Phone Dependence Among Chinese Rural Adolescents: The Role of Alexithymia and Mindfulness. ( 30949104 )	Li X...Hao C	2019
29	Shame and guilt mediate the effects of alexithymia on distress and suicide-related behaviours among men. ( 30950285 )	Rice SM...Ogrodniczuk JS	2019
30	Prevalence of alexithymia in eating disorders in a clinical sample of 800 Mexican patients. ( 30951037 )	Barriguete-Mel?ndez JA...Rojo-Moreno L	2019
31	Emotional intelligence, empathy and alexithymia: a cross-sectional survey on emotional competence in a group of nursing students. ( 30977747 )	Di Lorenzo R...Ferri P	2019
32	The role of long-term psychodynamic psychotherapy in improving attachment patterns, defense styles, and alexithymia in patients with depressive/anxiety disorders. ( 30994785 )	Khademi M...Faramarzi M	2019
33	Factors associated with the adults' attachment styles in Lebanon: The role of alexithymia, depression, anxiety, stress, burnout, and emotional intelligence. ( 31004358 )	Obeid S...Hallit S	2019
34	Alexithymia in individuals with chronic pain and its relation to pain intensity, physical interference, depression, and anxiety: a systematic review and meta-analysis. ( 31009416 )	Aaron RV...Palermo TM	2019
35	Alexithymia moderates effects of psychotherapeutic treatment expectations on depression outcome in interdisciplinary chronic pain treatment. ( 31010581 )	Blaettler LT...Grosse Holtforth M	2019
36	Interoceptive awareness, alexithymia, and sexual function. ( 31018783 )	Berenguer C...Miguel Costa R	2019
37	Mood Disorders in High-Functioning Autism: The Importance of Alexithymia and Emotional Regulation. ( 31028592 )	Morie KP...Dritschel B	2019
38	Alexithymia and Its Associations With Depression, Suicidality, and Aggression: An Overview of the Literature. ( 31031655 )	Hemming L...Pratt D	2019
39	Psychometric properties of the Toronto Alexithymia Scale (TAS-20) in Brazil. ( 31067154 )	Stivaleti Colombarolli M...Giromini L	2019
40	Memory for emotional information and alexithymia A systematic review. ( 31073377 )	Apg?ua LT...Jaeger A	2019
41	The relationship between levels of Alexithymia and communication skills of nursing students. ( 31086538 )	Sancar B...Aktas D	2019
42	A systematic review and meta-analysis of the association between alexithymia and suicide ideation and behaviour. ( 31103905 )	Hemming L...Pratt D	2019
43	Smartphone-based emotion recognition skills training for alexithymia - A randomized controlled pilot study. ( 31110950 )	Lukas CA...Berking M	2019
44	Factorial Validity of the Toronto Alexithymia Scale (TAS-20) in Clinical Samples: A Critical Examination of the Literature and a Psychometric Study in Anorexia Nervosa. ( 29603033 )	Torres S...Rocha M	2019
45	Influence of anxiety and alexithymia on brain activations associated with the perception of others' pain in autism. ( 29683406 )	Lassalle A...Hadjikhani N	2019
46	Alexithymia and tic disorders: a study on a sample of children and their mothers. ( 30056587 )	Silvestri PR...Cardona F	2019
47	Effects of mindfulness-based interventions on alexithymia: a systematic review. ( 30077988 )	Norman H...Oskis A	2019
48	Beneficial effects of bilateral subthalamic stimulation on alexithymia in Parkinson's disease. ( 30107062 )	Dafsari HS...Timmermann L	2019
49	Reversibility of alexithymia with effective treatment of moderate-to-severe psoriasis: longitudinal data from EPIDEPSO. ( 30269346 )	Sampogna F...Paul C	2019
50	The development and evaluation of a brief form of the Normative Male Alexithymia Scale (NMAS-BF). ( 30284847 )	Levant RF...Parent MC	2019

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Genes for Alexithymia

Genes related to Alexithymia (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ANKK1	Ankyrin Repeat And Kinase Domain Containing 1	Protein Coding	22.87	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	SLC6A4	Solute Carrier Family 6 Member 4	Protein Coding	22.79	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	COMT	Catechol-O-Methyltransferase	Protein Coding	22.11	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	OXTR	Oxytocin Receptor	Protein Coding	21.78	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	DRD2	Dopamine Receptor D2	Protein Coding	21.66	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	TAS2R38	Taste 2 Receptor Member 38	Protein Coding	21.08	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	CRP	C-Reactive Protein	Protein Coding	20.96	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	HTR1A	5-Hydroxytryptamine Receptor 1A	Protein Coding	20.57	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	IL4	Interleukin 4	Protein Coding	20.4	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	IL6	Interleukin 6	Protein Coding	19.96	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

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Variations for Alexithymia

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Expression for Alexithymia

Search GEO for disease gene expression data for Alexithymia.

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Pathways for Alexithymia

Pathways related to Alexithymia according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Selenium Micronutrient Network ¹ Show member pathways Folate Metabolism ¹ Metabolism of ingested MeSeO2H into MeSeH ⁶⁷ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	11.94	CRP IL4 IL6
2	Circadian rythm related genes ¹	11.9	DRD2 IL6 SLC6A4
3	cAMP signaling pathway ³⁸	11.82	DRD2 HTR1A OXTR
4	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	11.34	HTR1A IL6 SLC6A4
5	Development and heterogeneity of the ILC family ¹	10.96	IL4 IL6
6	Cytokines and Inflammatory Response ¹	10.83	IL4 IL6
7	Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics ⁶²	10.7	HTR1A SLC6A4
8	Neurotransmitter Clearance In The Synaptic Cleft ⁶⁷ Show member pathways Dopamine clearance from the synaptic cleft ⁶⁷ Enzymatic degradation of dopamine by COMT ⁶⁷ Enzymatic degradation of Dopamine by monoamine oxidase ⁶⁷ L-dopa degradation ¹ melatonin degradation II ¹ Metabolism of serotonin ⁶⁷ Serotonin clearance from the synaptic cleft ⁶⁷	10.59	COMT SLC6A4
9	Overview of nanoparticle effects ¹	9.9	CRP IL6

Sources

GO Terms for Alexithymia

Biological processes related to Alexithymia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of gene expression	GO:0010628	9.56	CRP IL4 IL6 SLC6A4
2	response to cocaine	GO:0042220	9.46	DRD2 OXTR
3	acute-phase response	GO:0006953	9.43	CRP IL6
4	response to amphetamine	GO:0001975	9.4	DRD2 OXTR
5	vasoconstriction	GO:0042310	9.37	HTR1A SLC6A4
6	dopamine metabolic process	GO:0042417	9.32	COMT DRD2
7	response to drug	GO:0042493	9.26	COMT DRD2 OXTR SLC6A4
8	negative regulation of lipid storage	GO:0010888	9.16	CRP IL6
9	sperm ejaculation	GO:0042713	8.62	OXTR SLC6A4

Molecular functions related to Alexithymia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	serotonin binding	GO:0051378	8.62	HTR1A SLC6A4

Sources

Sources for Alexithymia

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia