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MCID: ALX002
MIFTS: 36

Alexithymia

Categories: Mental diseases
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Aliases & Classifications for Alexithymia

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MalaCards integrated aliases for Alexithymia:

Name: Alexithymia 11 14 75

Classifications:

MalaCards categories:
Anatomical: Mental diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 11 DOID:0060131
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Summaries for Alexithymia

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Disease Ontology: 11 An agnosia that is a deficiency in understanding, processing, or describing emotions.

MalaCards based summary: Alexithymia is related to somatization disorder and chronic pain. An important gene associated with Alexithymia is OXT (Oxytocin/Neurophysin I Prepropeptide), and among its related pathways/superpathways are Antipsychotics Pathway (Metabolic Side Effects), Pharmacodynamics and Methylphenidate Pathway, Pharmacodynamics. The drugs Ethanol and Cocaine have been mentioned in the context of this disorder. Affiliated tissues include brain, prefrontal cortex and amygdala, and related phenotype is endocrine/exocrine gland.

Wikipedia: 75 Alexithymia is a personality trait characterized by the inability to identify and describe emotions... more...
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Related Diseases for Alexithymia

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Diseases related to Alexithymia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 452)
# Related Disease Score Top Affiliating Genes
1 somatization disorder 30.9 SLC6A4 OXT CRH
2 chronic pain 30.8 COMT BDNF
3 avoidant personality disorder 30.3 SLC6A4 PIR
4 autism spectrum disorder 30.3 SLC6A4 OXTR OXT DRD2 COMT BDNF
5 polysubstance abuse 30.2 DRD2 COMT
6 adult syndrome 30.1 H2AC18 CRP CRH
7 reading disorder 29.8 POLI OSTF1 CPZ
8 bulimia nervosa 29.7 SLC6A4 OXT HTR2A DRD2 COMT BDNF
9 narcissistic personality disorder 29.7 PIR OXT OSTF1 H2AC18
10 headache 29.7 SLC6A4 HTR2A COMT BDNF
11 cannabis dependence 29.7 DRD2 COMT ANKK1
12 autism 29.7 SLC6A4 OXTR OXT HTR2A DRD2 COMT
13 schizoid personality disorder 29.7 PIR DRD2 CPZ
14 hypochondriasis 29.6 SLC6A4 PIR OXT HTR2A BDNF
15 paine syndrome 29.6 SLC6A4 MIR548D1 H2AC18 CRH COMT BDNF
16 amnestic disorder 29.6 PDYN OXT BDNF
17 acute stress disorder 29.6 SLC6A4 PIR OXT HTR2A CRH BDNF
18 personality disorder 29.6 SLC6A4 OXTR HTR2A DRD2 CRH COMT
19 brunner syndrome 29.5 SLC6A4 HTR2A COMT
20 hypoactive sexual desire disorder 29.5 OXT HTR2A
21 conversion disorder 29.5 PIR HTR2A COMT BDNF
22 leptin deficiency or dysfunction 29.5 OXT CRP CRH BDNF
23 anorexia nervosa 29.4 SLC6A4 OXT HTR2A DRD2 CRH COMT
24 asperger syndrome 29.4 SLC6A4 OXTR OXT COMT BDNF
25 panic disorder 29.4 SLC6A4 HTR2A DRD2 CRH COMT BDNF
26 chronic fatigue syndrome 29.4 SLC6A4 H2AC18 CRP CRH BDNF
27 premature ejaculation 29.4 SLC6A4 OXT COMT BDNF
28 body dysmorphic disorder 29.3 SLC6A4 PIR OXT HTR2A
29 alcohol use disorder 29.2 SLC6A4 PDYN H2AC18 DRD2 CRP CRH
30 pathological gambling 29.2 SLC6A4 PIR PDYN HTR2A DRD2 COMT
31 fibromyalgia 29.2 SLC6A4 OXT HTR2A CRP CRH COMT
32 migraine with aura 29.2 SLC6A4 HTR2A DRD2
33 eating disorder 29.2 SLC6A4 OXTR OXT HTR2A H2AC18 DRD2
34 obsessive-compulsive personality disorder 29.2 SLC6A4 PIR HTR2A COMT
35 movement disease 29.1 HTR2A H2AC18 DRD2 COMT BDNF
36 tic disorder 29.1 SLC6A4 HTR2A DRD2 COMT
37 learning disability 29.1 POLI OSTF1 H2AC18 COMT BDNF
38 borderline personality disorder 29.1 SLC6A4 OXTR HTR2A DRD2 CRH COMT
39 schizotypal personality disorder 29.0 PIR HTR2A DRD2 CPZ COMT
40 irritable bowel syndrome 29.0 SLC6A4 HTR2A CRP CRH COMT BDNF
41 paranoid schizophrenia 28.9 SLC6A4 HTR2A H2AC18 DRD2 COMT BDNF
42 agnosia 28.9 PDYN OXT H2AC18 CRP CRH COMT
43 post-traumatic stress disorder 28.9 SLC6A4 OXTR OXT HTR2A H2AC18 DRD2
44 parkinson disease, late-onset 28.9 SLC6A4 PDYN HTR2A H2AC18 DRD2 COMT
45 speech and communication disorders 28.9 OXT OSTF1 CRP COMT BDNF
46 cocaine dependence 28.9 SLC6A4 PDYN DRD2 CRH COMT ANKK1
47 alcohol dependence 28.9 SLC6A4 PDYN HTR2A H2AC18 DRD2 CRH
48 apnea, obstructive sleep 28.8 HTR2A CRP BDNF
49 postpartum depression 28.8 SLC6A4 OXTR OXT HTR2A CRH COMT
50 atypical depressive disorder 28.8 SLC6A4 HTR2A CRP CRH BDNF

Graphical network of the top 20 diseases related to Alexithymia:



Diseases related to Alexithymia
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Symptoms & Phenotypes for Alexithymia

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MGI Mouse Phenotypes related to Alexithymia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.28 BDNF COMT CRH DRD2 HTR2A OXT
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Drugs & Therapeutics for Alexithymia

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Drugs for Alexithymia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved 64-17-5 702
2
Cocaine Approved, Illicit 50-36-2 446220 5760

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 Understanding Alexithymia Unknown status NCT00830752
2 Evaluation of Art-therapy on Alexithymia in Patients Suffering From Anorexia Nervosa and From Bulimia,a Pilot Study Unknown status NCT03524443
3 Alexithymia Frequency and Interhemispheric Transfer in Patients With a First Demyelinating Event: Initial Phase of Multiple Sclerosis Completed NCT03796247
4 Symptom, Alexithymia and Self-image Outcomes of Mentalization-Based Treatment for Borderline Personality Disorder: a Naturalistic Study Completed NCT03295838
5 Alexithymia in Ankylosing Spondylitis Completed NCT04320459
6 The Effect of Aerobic Exercise on Pain, Alexithymia Level and Quality of Life in Alexithymic Individuals With Chronic Pain Completed NCT05460806
7 Asthma, Smoking, Emotional Deficits Completed NCT03312673
8 Decoupling as Internet Based Intervention: an Randomized Controlled Study to Treat Trichotillomania Completed NCT02044237
9 The Emotion Builder: An Intervention for Emotional Deficits After Brain Injury Completed NCT02432300
10 Impact of Art Therapy on Alexithymia in People With Alcohol Use Disorder Recruiting NCT04206930
11 Effects of 12-week Aerobic and Resistance Exercises on Alexithymia, Depression and Quality of Life in Geriatric Individuals Recruiting NCT05342142
12 The Effects of Green Exercise Program Consisting of 12-week Aerobic and Resistance Exercises on Sleep Quality, Alexithymia, Anxiety and Depression in Elderly People Recruiting NCT05280249
13 The Effect of the Art-based Mandala Intervention on the Quality of Life of Cancer Patients Receiving Chemotherapy Recruiting NCT05344820
14 Training to Reconnect With Emotional Awareness Therapy Recruiting NCT03414463
15 Process of Regulation in Addictions: Vulnerability Emotional Factors to Craving Recruiting NCT05076201
16 Building Emotional Self-Awareness Teletherapy (BEST): A Tool to Optimize Psychological Health Outcomes for Persons With Traumatic Brain Injury Not yet recruiting NCT05623046
17 Psychological Impact, Metabolic Control, and Biological Stress Markers in Diabetes: Intervention Study With Affect School and Basal Body Awareness Terminated NCT01498614
18 Psychological Impact, Metabolic Control, Biological Stress Markers in Diabetes: Intervention With Affect School and Basal Body Awareness Withdrawn NCT01714986

Search NIH Clinical Center for Alexithymia

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Genetic Tests for Alexithymia

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Anatomical Context for Alexithymia

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Organs/tissues related to Alexithymia:

MalaCards : Brain, Prefrontal Cortex, Amygdala, Breast, Heart, Subthalamic Nucleus, Eye
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Publications for Alexithymia

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Articles related to Alexithymia:

(show top 50) (show all 3622)
# Title Authors PMID Year
1
'Can we predict aggression?'-Determining the predictors of aggression among individuals with substance use disorder in China undergoing enforced detoxification through machine learning. 62
36209778 2023
2
The Relationship of Alexithymia to Pain and Other Symptoms in Fibromyalgia: A Systematic Review and Meta-analysis. 62
36471652 2022
3
How are the youth? A brief-longitudinal study on symptoms, alexithymia and expressive suppression among Italian adolescents during COVID-19 pandemic. 62
35729091 2022
4
Autism traits dimensionality and multivariate relationship with alexithymia and anxiety in the general population. 62
36240538 2022
5
The Impact of Resilience, Alexithymia and Subjectively Perceived Helplessness of Myocardial Infarction on the Risk of Posttraumatic Stress. 62
35169973 2022
6
Impact of facemasks on psychotherapy: Clinician's confidence and emotion recognition. 62
36459660 2022
7
Alexithymia and psychological distress in fibromyalgia and chronic migraine: A cross-sectional study. 62
36228434 2022
8
Revisiting the association between self-reported empathy and behavioral assessments of social cognition. 62
35980708 2022
9
Depression in Chinese men with methamphetamine dependence: Prevalence, correlates and relationship with alexithymia. 62
36162653 2022
10
The Structure of the Toronto Alexithymia Scale (TAS-20): A Meta-Analytic Confirmatory Factor Analysis. 62
34311556 2022
11
Emotional regulation deficits in autism spectrum disorder: The role of alexithymia and interoception. 62
36410287 2022
12
Roles for Alexithymia, Emotion Dysregulation and Personality Features in Gambling Disorder: A Network Analysis. 62
36434175 2022
13
Alexithymia Among People Living with HIV: A Scoping Review. 62
36367612 2022
14
Sex-differences in hikikomori traits as predictors of problematic internet use in Italian university students. 62
36075117 2022
15
[Dental anxiety and alexithymia; research on anxiety acquisition]. 62
36345677 2022
16
Alexithymia and related factors among patients with epilepsy. 62
36399970 2022
17
Core clinical symptoms and suicidal ideation in patients with obsessive-compulsive disorder: A network analysis. 62
36330993 2022
18
Alexithymia in systemic lupus erythematosus: A cross sectional study in a Brazilian sample. 62
36399013 2022
19
The prevalence and characteristics of alexithymia in patients with type 2 diabetes mellitus: A systematic review and meta-analysis. 62
36088789 2022
20
Prognostic factors for low-risk drinking and relapse in alcohol use disorder: A multimodal analysis. 62
36301210 2022
21
Apparent autistic traits in transgender people: a prospective study of the impact of gender-affirming hormonal treatment. 62
35779204 2022
22
Patients' response to moments of disappointment with their therapist: the roles of disappointment experience, emotional abilities, and perceived alliance negotiation. 62
36395433 2022
23
Daily Associations of Sleep Quality and Sleep Duration with Anxiety in Young Adults: The Moderating Effect of Alexithymia. 62
34927498 2022
24
Evaluation of Psychological Resilience, Alexithymia, and Impulsivity Characteristics in Persons Who Attempted Suicide with Drugs. 62
36441644 2022
25
Prevalence and Relationships between Alexithymia, Anhedonia, Depression and Anxiety during the Belgian COVID-19 Pandemic Lockdown. 62
36430003 2022
26
Effects of DBT-based interventions on alexithymia: a systematic review. 62
36426727 2022
27
Bi-factor and Second-Order Copula Models for Item Response Data. 62
36414825 2022
28
Metacognitive interpersonal therapy in group versus TAU + waiting list for young adults with personality disorders: Randomized clinical trial. 62
34383540 2022
29
Pain and masochistic behaviour: The role of descending modulation. 62
36094743 2022
30
Predicting depression and anxiety of Chinese population during COVID-19 in psychological evaluation data by XGBoost. 62
36462608 2022
31
Effects of childhood trauma on nonsuicidal self-injury in adolescent patients with bipolar II depression. 62
36168882 2022
32
The prevalence of depression in isolated/idiopathic rapid eye movement sleep behavior disorder: A systematic review and meta-analysis. 62
36150254 2022
33
A Pre-Adolescent and Adolescent Clinical Sample Study about Suicidal Ideation, Suicide Attempt, and Self-Harming. 62
36286085 2022
34
The percentage and clinical correlates of alexithymia in stable patients with schizophrenia. 62
36239818 2022
35
Furthering the language hypothesis of alexithymia: An integrated review and meta-analysis. 62
36087760 2022
36
Perceptive and affective impairments in emotive eye-region processing in alexithymia. 62
35277722 2022
37
Somatic, Emotional and Behavioral Symptomatology in Children during COVID-19 Pandemic: The Role of Children's and Parents' Alexithymia. 62
36360512 2022
38
Prevalence and associated factors of alexithymia among medical students: A cross-sectional study from Saudi Arabia. 62
36252975 2022
39
Early Trauma and Later Sexual Victimization in College Women: A Multiple Mediation Examination of Alexithymia, Impulsivity, and Alcohol Use. 62
34388947 2022
40
Effect of alexithymia and difficulty of emotion regulation, neuroticism, low extraversion, and suicidality on quality of life in epilepsy. 62
36037582 2022
41
The Association Between Upper Disorders and Psychological Well-Being and its Implication in Text Neck Syndrome: A Systematic Review. 62
36340273 2022
42
Exploring the contributions of affective constructs and interoceptive awareness to feeling fat. 62
36261777 2022
43
Relationship Between Warm Childhood Memories and Mobile Phone Addiction: A Moderated Mediation Model. 62
36269848 2022
44
The Mediating Effects of Alexithymia, Intolerance of Uncertainty, and Anxiety on the Relationship Between Sensory Processing Differences and Restricted and Repetitive Behaviours in Autistic Adults. 62
34643864 2022
45
[Interoceptive difficulties in children and adolescents with severe form of somatic symptom disorder: A pilot study with nineteen participants]. 62
36244837 2022
46
The prevalence of alexithymia in psoriasis: A systematic review and meta-analysis. 62
36041345 2022
47
Impulsivity and alexithymia predict early versus subsequent relapse in patients with alcohol use disorder: A 1-year longitudinal study. 62
36269103 2022
48
Alexithymia, narcissism and social anxiety in relation to social media and internet addiction symptoms. 62
35262189 2022
49
Emotion recognition, alexithymia, empathy, and emotion regulation in women with anorexia nervosa. 62
36258146 2022
50
Posttraumatic stress and alexithymia: A meta-analysis of presentation and severity. 62
31841012 2022
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Variations for Alexithymia

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Expression for Alexithymia

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Search GEO for disease gene expression data for Alexithymia.
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Pathways for Alexithymia

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Pathways related to Alexithymia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Antipsychotics Pathway (Metabolic Side Effects), Pharmacodynamics 60
10.46 DRD2 ANKK1
2
Methylphenidate Pathway, Pharmacodynamics 60
Show member pathways
 10.16 SLC6A4 DRD2 COMT
3
Vasopressin-like receptors 66
Show member pathways
 10 OXTR OXT
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GO Terms for Alexithymia

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Cellular components related to Alexithymia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.93 SRSF10 PDYN HTR2A DRD2 COMT BDNF
2 axon terminus GO:0043679 9.73 SRSF10 PDYN DRD2
3 obsolete integral component of presynaptic membrane GO:0099056 9.13 SLC6A4 HTR2A DRD2
4 obsolete integral component of postsynaptic membrane GO:0099055 8.8 SLC6A4 HTR2A DRD2

Biological processes related to Alexithymia according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of synapse assembly GO:0051965 9.99 OXTR OXT BDNF
2 social behavior GO:0035176 9.95 SLC6A4 OXTR OXT
3 response to amphetamine GO:0001975 9.85 DRD2 OXT OXTR
4 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.84 HTR2A DRD2
5 drinking behavior GO:0042756 9.83 OXT DRD2
6 positive regulation of uterine smooth muscle contraction GO:0070474 9.8 OXTR OXT
7 response to cocaine GO:0042220 9.8 OXTR OXT DRD2
8 negative regulation of gastric acid secretion GO:0060455 9.76 OXTR OXT
9 positive regulation of penile erection GO:0060406 9.73 OXTR OXT
10 positive regulation of norepinephrine secretion GO:0010701 9.71 OXTR OXT
11 sleep GO:0030431 9.63 OXTR OXT HTR2A
12 sperm ejaculation GO:0042713 9.43 SLC6A4 OXTR OXT
13 memory GO:0007613 9.32 SLC6A4 OXTR OXT HTR2A BDNF
14 regulation of digestive system process GO:0044058 9.26 OXTR OXT
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Sources for Alexithymia

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2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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