Aliases & Classifications for Alexithymia

MalaCards integrated aliases for Alexithymia:

Name: Alexithymia 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060131

Summaries for Alexithymia

Disease Ontology : 12 An agnosia that is a deficiency in understanding, processing, or describing emotions.

MalaCards based summary : Alexithymia is related to anxiety and eating disorder. An important gene associated with Alexithymia is ANKK1 (Ankyrin Repeat And Kinase Domain Containing 1), and among its related pathways/superpathways are cAMP signaling pathway and Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics. The drugs Cycloserine and Ketamine have been mentioned in the context of this disorder. Affiliated tissues include brain, breast and testes, and related phenotypes are cardiovascular system and endocrine/exocrine gland

Wikipedia : 76 Alexithymia /�?eɪl�?ks�?�?θaɪmi�?/ is a personality construct characterized by the subclinical inability... more...

Related Diseases for Alexithymia

Diseases related to Alexithymia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 185)
# Related Disease Score Top Affiliating Genes
1 anxiety 30.8 COMT HTR1A SLC6A4
2 eating disorder 30.7 COMT DRD2 SLC6A4
3 fibromyalgia 30.7 COMT SLC6A4
4 traumatic brain injury 30.6 COMT DRD2
5 brain injury 30.6 COMT DRD2
6 somatoform disorder 30.4 COMT IL4
7 pathological gambling 30.2 DRD2 SLC6A4
8 panic disorder 30.2 COMT HTR1A SLC6A4
9 borderline personality disorder 30.2 COMT HTR1A SLC6A4
10 post-traumatic stress disorder 30.0 COMT CRP DRD2 SLC6A4
11 personality disorder 30.0 ANKK1 COMT DRD2 HTR1A SLC6A4
12 autism 30.0 COMT DRD2 HTR1A OXTR SLC6A4
13 schizophrenia 29.9 COMT DRD2 HTR1A SLC6A4
14 alcohol abuse 29.8 ANKK1 DRD2 SLC6A4
15 paranoid schizophrenia 29.8 COMT SLC6A4
16 obsessive-compulsive disorder 29.8 COMT DRD2 HTR1A OXTR SLC6A4
17 chronic fatigue syndrome 29.7 COMT HTR1A SLC6A4
18 dyspepsia 29.7 HTR1A SLC6A4
19 major depressive disorder 29.6 COMT DRD2 HTR1A OXTR SLC6A4
20 social phobia 29.6 DRD2 HTR1A SLC6A4
21 generalized anxiety disorder 29.6 COMT DRD2 HTR1A SLC6A4
22 mood disorder 29.4 COMT DRD2 HTR1A SLC6A4
23 antisocial personality disorder 29.4 ANKK1 COMT DRD2 SLC6A4
24 premature ejaculation 29.4 COMT HTR1A SLC6A4
25 migraine without aura 29.4 DRD2 HTR1A SLC6A4
26 psychotic disorder 29.2 COMT DRD2 HTR1A SLC6A4
27 migraine with or without aura 1 29.2 COMT DRD2 HTR1A SLC6A4
28 parkinson disease, late-onset 29.2 COMT DRD2 HTR1A SLC6A4
29 bipolar disorder 29.2 COMT DRD2 HTR1A SLC6A4
30 alcohol dependence 29.0 ANKK1 COMT DRD2 HTR1A SLC6A4
31 attention deficit-hyperactivity disorder 29.0 ANKK1 COMT DRD2 HTR1A SLC6A4
32 disease of mental health 28.9 COMT DRD2 HTR1A OXTR SLC6A4
33 social emotional agnosia 11.1
34 depression 10.7
35 anorexia nervosa 10.2
36 pain - chronic 10.2
37 alcohol-induced mental disorder 10.2 DRD2 SLC6A4
38 schizophreniform disorder 10.2 COMT DRD2
39 alcoholic psychosis 10.2 DRD2 SLC6A4
40 polysubstance abuse 10.2 COMT DRD2
41 tardive dyskinesia 10.2 COMT DRD2
42 opioid addiction 10.2 COMT DRD2
43 opiate dependence 10.2 DRD2 SLC6A4
44 autism spectrum disorder 10.1
45 psoriasis 10.1
46 impulse control disorder 10.1 ANKK1 DRD2
47 cocaine abuse 10.1 DRD2 SLC6A4
48 taqi polymorphism 10.1 ANKK1 DRD2
49 heroin dependence 10.1 ANKK1 DRD2
50 mycoplasma pneumoniae pneumonia 10.1 CRP IL4

Graphical network of the top 20 diseases related to Alexithymia:



Diseases related to Alexithymia

Symptoms & Phenotypes for Alexithymia

MGI Mouse Phenotypes related to Alexithymia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.43 ABCB4 COMT CRP DRD2 HTR1A SLC6A4
2 endocrine/exocrine gland MP:0005379 9.1 ABCB4 COMT DRD2 IL4 OXTR SLC6A4

Drugs & Therapeutics for Alexithymia

Drugs for Alexithymia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 64)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cycloserine Approved Phase 4 68-41-7 6234 401
2
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
3
Sertraline Approved Phase 4 79617-96-2 68617
4 Antitubercular Agents Phase 4
5 Anti-Infective Agents Phase 4,Phase 1
6 Central Nervous System Depressants Phase 4,Phase 2
7 Neurotransmitter Agents Phase 4,Phase 2
8 Anti-Infective Agents, Urinary Phase 4
9 Anesthetics, Dissociative Phase 4
10 Antidepressive Agents Phase 4
11 Anti-Bacterial Agents Phase 4
12 Excitatory Amino Acids Phase 4
13 Analgesics Phase 4
14 Excitatory Amino Acid Antagonists Phase 4
15 Antibiotics, Antitubercular Phase 4
16 Peripheral Nervous System Agents Phase 4
17 Antimetabolites Phase 4
18 Renal Agents Phase 4
19 Anesthetics, Intravenous Phase 4
20 Anesthetics Phase 4
21 Anesthetics, General Phase 4
22 Serotonin Uptake Inhibitors Phase 4
23 Serotonin Agents Phase 4,Phase 2
24 Psychotropic Drugs Phase 4,Phase 2,Not Applicable
25 Neurotransmitter Uptake Inhibitors Phase 4,Phase 2
26
Serotonin Investigational, Nutraceutical Phase 4,Phase 2 50-67-9 5202
27
Oxytocin Approved, Vet_approved Phase 2,Not Applicable 50-56-6 439302 53477758
28
Zopiclone Approved Phase 2 43200-80-2 5735
29
3,4-Methylenedioxyamphetamine Experimental, Illicit Phase 2 4764-17-4 1614
30 Oxytocics Phase 2,Not Applicable
31 Hypnotics and Sedatives Phase 2
32 N-Methyl-3,4-methylenedioxyamphetamine Phase 2
33 Adrenergic Agents Phase 2
34 Hallucinogens Phase 2
35
Acetylcysteine Approved, Investigational Phase 1 616-91-1 12035
36 Antiviral Agents Phase 1
37 Vitamins Phase 1
38 Antioxidants Phase 1
39 Respiratory System Agents Phase 1
40 Antidotes Phase 1
41 Expectorants Phase 1
42 Free Radical Scavengers Phase 1
43 Protective Agents Phase 1
44 N-monoacetylcystine Phase 1
45
Hydrocortisone Approved, Vet_approved 50-23-7 5754
46
Hydrocortisone acetate Approved, Vet_approved 50-03-3
47
Dopamine Approved 51-61-6, 62-31-7 681
48
Norepinephrine Approved 51-41-2 439260
49
Ethanol Approved 64-17-5 702
50
Zinc oxide Approved Not Applicable 1314-13-2

Interventional clinical trials:

(show top 50) (show all 63)
# Name Status NCT ID Phase Drugs
1 D-cycloserine for Relapse Prevention Following Intravenous Ketamine in Treatment-resistant Depression Unknown status NCT02772211 Phase 4 Ketamine;D-cycloserine;Placebo
2 Cognitive Behavioral Therapy Versus Sertraline in the Treatment of Post-Traumatic Stress Disorder Completed NCT00391430 Phase 4 Sertraline
3 Autism Oxytocin Brain Project Completed NCT03033784 Phase 2 Oxytocin;Oxytocin;Oxytocin;Placebo
4 Impact of a Group Intervention on Breast Cancer Patient's Adjustment and Emotion Regulation at the End of Treatment Completed NCT01797354 Phase 2
5 Effectiveness of BBT-I and Zopiclone for Chronic Insomnia Completed NCT03339583 Phase 2 Zopiclone
6 MDMA-assisted Therapy for Social Anxiety in Autistic Adults Completed NCT02008396 Phase 2 Placebo;MDMA
7 Pain and Stress Management for Fibromyalgia Completed NCT01287481 Phase 2
8 Ocytocine and Cerebral Activation in Relation With Attachement Recruiting NCT02847143 Phase 2 nasal oxytocin or placebo
9 Early Study of N-Acetylcysteine to Treat Deliberate Self-Harm in Adolescents Completed NCT01111734 Phase 1 fMRI
10 Neurobiological, Neuropsychological,Linguistic and Gestural Processes and Phenomena in Individuals With Alexithymia Unknown status NCT00830752
11 Psychopathological Risk Factors Associated With Conversion From Mild Cognitive Impairment to Dementia Unknown status NCT01436552
12 Halifax Treatment Refractory Depression Trial Unknown status NCT01141426 Not Applicable
13 Alexithymia Frequency and Interhemispheric Transfer in Patients With a First Demyelinating Event Completed NCT03796247
14 The Emotion Builder: An Intervention for Emotional Deficits After Brain Injury Completed NCT02432300 Not Applicable
15 Online Treatment of Trichotillomania Completed NCT02044237 Not Applicable
16 Clinical Assessment and Psychosocial Impact of Psoriasis Completed NCT01964443
17 Outcomes of Mentalization-Based Treatment for Borderline Personality Disorder Completed NCT03295838 Not Applicable
18 Moderating Impact of Various Emotion Personality Factors on Salivary Cortisol Response to a TSST Completed NCT00451126
19 Effectiveness of Standard Emergency Department Psychiatric Treatment Associated With Treatment Delivery by a Suicide Prevention Center Completed NCT00641498 Not Applicable
20 Attention Bias Modification Treatment for Warzone-Related Posttraumatic Stress Disorder (PTSD) Completed NCT01564667 Not Applicable
21 Service Member Fatigue and Lack of Motivation Following Concussion Completed NCT01496586
22 Functional Neuroanatomy and Regional Metabolism Before and After Treatment With Duloxetine Completed NCT02658617
23 Research Project About Psychological Strain, Quality of Life and Emotional Awareness in Patients With Tinnitus Completed NCT01837368
24 A SYNdemic BASed INtervention for MSM With High Risk Behavior: Design of a Randomized Controlled Trial Completed NCT02859935 Not Applicable
25 Depression Online Assessment and Therapy Completed NCT02112266 Not Applicable
26 Mindfulness in Preparation to Bariatric Surgery Completed NCT02854306 Not Applicable
27 The Effectiveness of Mindfulness on Chronic Pain in Breast Cancer Survivors Completed NCT01674881 Not Applicable
28 Electrophysiological Correlates of Emotional and Crossmodal Stimuli Processing Among Alcohol-dependent Participants Completed NCT01633905
29 Plasticity of the Compassionate Brain Completed NCT01833104 Not Applicable
30 Oculomotor Markers and Attachment in Adolescents Completed NCT02851810 Not Applicable
31 Stress Management for Irritable Bowel Syndrome Completed NCT01886027 Not Applicable
32 Mindfulness for Irritable Bowel Syndrome Completed NCT02794376 Not Applicable
33 Improving Happiness in Flanders Completed NCT02041741 Not Applicable
34 Chronic Low Back Pain: A Multidisciplinary Approach Completed NCT01993355 Not Applicable
35 Training to Reconnect With Emotional Awareness Therapy Recruiting NCT03414463 Not Applicable
36 Positive Emotion Regulation Training in Children, Adolescents and Young Adults With and Without Developmental Disorder Recruiting NCT02898298 Not Applicable
37 Re-nutrition in Severe Anorexia Nervosa Recruiting NCT02502617
38 CBT-Eb Plus EMDR Versus CBT-Eb in Patients With Eating Disorders Recruiting NCT03156959 Not Applicable
39 Childhood Trauma in Schizophrenia: Exploration of Links Between Gene Expression, Cerebral Morphology and Symptomatology Recruiting NCT03355781
40 Psychological Predictors in Colorectal Cancer Surgery Recovery Recruiting NCT03781193
41 Influence of Main Psychological and Social Factors on Primary Headaches Recruiting NCT03577548
42 Student Outcomes of Integrative Mental Health Services Recruiting NCT02877875 Not Applicable
43 Olfactory Training and Emotional State Recruiting NCT03605524 Not Applicable
44 Can Cognitive Training Decrease Reactive Aggression? Recruiting NCT03623477 Not Applicable
45 Randomized Controlled Study of the Efficacy of Hypnosis Versus Relaxation and Control in Neuropathic Pain Recruiting NCT02256371 Not Applicable
46 Family Therapy and Anorexia Nervosa : Which is the Best Approach? Recruiting NCT03350594 Not Applicable
47 Improving Emotion Regulation Skills Among Adolescents Attempting to Lose Weight Recruiting NCT03393221 Not Applicable
48 Effectiveness of Buprenorphine/Naloxone Recruiting NCT02882412
49 Effects of Prenatal Alcohol Exposure on Emotional and Cognitive Abilities in Adults Active, not recruiting NCT03793920 Not Applicable
50 Mental Training for CFS Following EBV Infection in Adolescents Active, not recruiting NCT02499302 Not Applicable

Search NIH Clinical Center for Alexithymia

Genetic Tests for Alexithymia

Anatomical Context for Alexithymia

MalaCards organs/tissues related to Alexithymia:

41
Brain, Breast, Testes, Heart, Amygdala, Skin, Eye

Publications for Alexithymia

Articles related to Alexithymia:

(show top 50) (show all 1037)
# Title Authors Year
1
Duration of breastfeeding is associated with emotional eating through its effect on alexithymia in boys, but not girls. ( 30315844 )
2019
2
Attachment avoidance, alexithymia, and gender: Examining their associations with distress disclosure tendencies and event-specific disclosure. ( 29355345 )
2018
3
Is alexithymia characterised by impaired interoception? Further evidence, the importance of control variables, and the problems with the Heartbeat Counting Task. ( 29803614 )
2018
4
Body talk: Sex differences in the influence of alexithymia on physical complaints among psychiatric outpatients. ( 29309955 )
2018
5
Affect labeling and other aspects of emotional experiences in relation to alexithymia following standardized emotion inductions. ( 29428774 )
2018
6
Childhood Trauma and Functional Variants of 5-HTTLPR Are Independently Associated with Alexithymia in 5,283 Subjects from the General Population. ( 29306941 )
2018
7
Psychoeducation against depression, anxiety, alexithymia and fibromyalgia: a pilot study in primary care for patients on sick leave. ( 29693478 )
2018
8
The functional and structural characteristics of the emotion network in alexithymia. ( 29695908 )
2018
9
Alexithymia and autistic traits as possible predictors for traits related to depression, anxiety, and stress: A multivariate statistical approach. ( 29882629 )
2018
10
Subjective and Objective: Alexithymia and Social Cognition in Eating Disorders. ( 29916406 )
2018
11
Psychometric Properties of the Bermond-Vorst Alexithymia Questionnaire (BVAQ) in the General Population and a Clinical Population. ( 29740350 )
2018
12
Association of Internet addiction and alexithymia - A scoping review. ( 29429757 )
2018
13
Alexithymia as a potential source of symptom over-reporting: An exploratory study in forensic patients and non-forensic participants. ( 29349809 )
2018
14
Are alexithymia and empathy predicting factors of the resilience of medical residents in France? ( 29731450 )
2018
15
Headache and Alexithymia in Children and Adolescents: What Is the Connection? ( 29449820 )
2018
16
Association Between Alexithymia and Functional Gastrointestinal Disorders. ( 29922191 )
2018
17
Do terrorists suffer from alexithymia? ( 29417660 )
2018
18
The influence of alexithymia on mobile phone addiction: The role of depression, anxiety and stress. ( 28926906 )
2018
19
Language and alexithymia: Evidence for the role of the inferior frontal gyrus in acquired alexithymia. ( 29360519 )
2018
20
Alexithymia and Somatosensory Amplification Link Perceived Psychosocial Stress and Somatic Symptoms in Outpatients with Psychosomatic Illness. ( 29748483 )
2018
21
Symptom, alexithymia and self-image outcomes of Mentalisation-based treatment for borderline personality disorder: a naturalistic study. ( 29890960 )
2018
22
Assessing advanced theory of mind and alexithymia in patients suffering from enduring borderline personality disorder. ( 29360051 )
2018
23
The Relationship Between Alexithymia and Emotional Awareness: A Meta-Analytic Review of the Correlation Between TAS-20 and LEAS. ( 29713295 )
2018
24
Bullying and alexithymia: Are there differences between traditional, cyber, combined bullies, and nonbullies in reading their own emotions? ( 29952143 )
2018
25
The Impact of Alexithymia on Emotion Dysregulation in Anorexia Nervosa and Bulimia Nervosa over Time. ( 29266572 )
2018
26
The relationship between alexithymia and headache impact: the role of somatization and pain catastrophizing. ( 29869297 )
2018
27
Influence of anxiety and alexithymia on brain activations associated with the perception of others' pain in autism. ( 29683406 )
2018
28
Psychometric Properties of the 20-Item Toronto Alexithymia Scale in the Chilean Population. ( 29946289 )
2018
29
A scoping review of suicidality and alexithymia: The need to consider interoception. ( 29913380 )
2018
30
Traumatic Experiences, Stressful Events, and Alexithymia in Chronic Migraine With Medication Overuse. ( 29867669 )
2018
31
Looking at the eyes interferes with facial emotion recognition in alexithymia. ( 29792440 )
2018
32
Alexithymia in Young Adults With Substance Use Disorders: Critical Issues About Specificity and Treatment Predictivity. ( 29872408 )
2018
33
Correlations between TSIA and TAS-20 and their relation to self-reported negative affect: A study using a multi-method approach in the assessment of alexithymia in a nonclinical sample from Italy. ( 30261408 )
2018
34
Reversibility of alexithymia with effective treatment of moderate-to-severe psoriasis: longitudinal data from EPIDEPSO. ( 30269346 )
2018
35
Alexithymia and reactive aggression: The role of the amygdala. ( 30273792 )
2018
36
The development and evaluation of a brief form of the Normative Male Alexithymia Scale (NMAS-BF). ( 30284847 )
2018
37
The relationship between college students' alexithymia and mobile phone addiction: Testing mediation and moderation effects. ( 30309326 )
2018
38
Alexithymia, Impulsivity, and Reward Sensitivity in Young Adult University Student Children of Alcoholics. ( 30321089 )
2018
39
Alexithymia affects patients with hidradenitis suppurativa. ( 30325328 )
2018
40
Alexithymia is associated with aggressive tendencies following traumatic brain injury. ( 30373401 )
2018
41
Fearful Attachment Linked to Childhood Abuse, Alexithymia, and Depression in Motor Functional Neurological Disorders. ( 30376786 )
2018
42
Is it the Taste or the Buzz? Alexithymia, Caffeine, and Emotional Eating. ( 30380968 )
2018
43
Interacting and dissociable effects of alexithymia and depression on empathy. ( 30384283 )
2018
44
Abnormal Illness Behavior, Alexithymia, Demoralization, and Other Clinically Relevant Psychosocial Syndromes in Kidney Transplant Recipients: A Comparative Study of the Diagnostic Criteria for Psychosomatic Research System versus ICD-10 Psychiatric Nosology. ( 30391961 )
2018
45
Body image, personality profiles and alexithymia in patients with polycystic ovary syndrome (PCOS). ( 30398405 )
2018
46
Investigating alexithymia in autism: A systematic review and meta-analysis. ( 30399531 )
2018
47
Somatosensory amplification, health anxiety, and alexithymia in generalized anxiety disorder. ( 30416291 )
2018
48
Relationship Between Attachment Style in Adulthood, Alexithymia, and Dissociation in Alcohol Use Disorder Inpatients. Mediational Model. ( 30425669 )
2018
49
Alcohol and tobacco use in men: the role of alexithymia and externally oriented thinking style. ( 30427739 )
2018
50
Alexithymia explains increased empathic personal distress in individuals with and without eating disorders. ( 30428774 )
2018

Variations for Alexithymia

Expression for Alexithymia

Search GEO for disease gene expression data for Alexithymia.

Pathways for Alexithymia

GO Terms for Alexithymia

Cellular components related to Alexithymia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.02 ABCB4 DRD2 HTR1A OXTR SLC6A4
2 integral component of postsynaptic membrane GO:0099055 8.96 DRD2 SLC6A4

Biological processes related to Alexithymia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 social behavior GO:0035176 9.4 OXTR SLC6A4
2 response to cocaine GO:0042220 9.37 DRD2 OXTR
3 response to amphetamine GO:0001975 9.32 DRD2 OXTR
4 vasoconstriction GO:0042310 9.26 HTR1A SLC6A4
5 dopamine metabolic process GO:0042417 9.16 COMT DRD2
6 response to drug GO:0042493 9.02 ABCB4 COMT DRD2 OXTR SLC6A4
7 sperm ejaculation GO:0042713 8.96 OXTR SLC6A4

Molecular functions related to Alexithymia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor activity GO:0004930 9.26 DRD2 HTR1A OXTR TAS2R38
2 serotonin binding GO:0051378 8.62 HTR1A SLC6A4

Sources for Alexithymia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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