Aliases & Classifications for Alexithymia

MalaCards integrated aliases for Alexithymia:

Name: Alexithymia 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060131

Summaries for Alexithymia

Disease Ontology : 12 An agnosia that is a deficiency in understanding, processing, or describing emotions.

MalaCards based summary : Alexithymia is related to eating disorder and anxiety. An important gene associated with Alexithymia is ANKK1 (Ankyrin Repeat And Kinase Domain Containing 1), and among its related pathways/superpathways are Selenium Micronutrient Network and Circadian rythm related genes. The drugs Cycloserine and Ketamine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and breast, and related phenotypes are endocrine/exocrine gland and nervous system

Wikipedia : 77 Alexithymia is a personality construct characterized by the subclinical inability to identify and... more...

Related Diseases for Alexithymia

Diseases related to Alexithymia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 249)
# Related Disease Score Top Affiliating Genes
1 eating disorder 31.0 COMT DRD2 SLC6A4
2 anxiety 30.8 COMT HTR1A SLC6A4
3 fibromyalgia 30.6 COMT IL6 SLC6A4
4 traumatic brain injury 30.5 COMT DRD2 IL6
5 brain injury 30.5 COMT DRD2 IL6
6 pathological gambling 30.5 DRD2 SLC6A4
7 panic disorder 30.4 COMT HTR1A SLC6A4
8 somatoform disorder 30.4 COMT IL4
9 post-traumatic stress disorder 30.2 COMT CRP DRD2 SLC6A4
10 borderline personality disorder 30.2 COMT HTR1A SLC6A4
11 inflammatory bowel disease 30.1 CRP IL4 IL6
12 substance abuse 30.0 COMT DRD2 SLC6A4
13 paranoid schizophrenia 29.9 COMT SLC6A4
14 alcohol abuse 29.9 ANKK1 DRD2 SLC6A4
15 substance dependence 29.8 DRD2 IL6 SLC6A4
16 personality disorder 29.8 ANKK1 COMT DRD2 HTR1A SLC6A4
17 mental depression 29.7 COMT HTR1A SLC6A4
18 premature ejaculation 29.6 HTR1A SLC6A4
19 social phobia 29.6 DRD2 HTR1A SLC6A4
20 obsessive-compulsive disorder 29.5 COMT DRD2 HTR1A OXTR SLC6A4
21 periodontitis 29.5 CRP IL4 IL6
22 intermittent claudication 29.5 CRP IL6
23 generalized anxiety disorder 29.5 COMT DRD2 HTR1A SLC6A4
24 migraine with or without aura 1 29.5 COMT DRD2 HTR1A SLC6A4
25 antisocial personality disorder 29.4 ANKK1 COMT DRD2 SLC6A4
26 tobacco addiction 29.4 ANKK1 COMT DRD2 SLC6A4
27 migraine without aura 29.4 DRD2 HTR1A SLC6A4
28 bipolar disorder 29.3 COMT DRD2 HTR1A SLC6A4
29 chronic fatigue syndrome 29.3 COMT HTR1A IL6 SLC6A4
30 psychotic disorder 29.1 COMT DRD2 HTR1A SLC6A4
31 parkinson disease, late-onset 29.1 COMT DRD2 HTR1A SLC6A4
32 major depressive disorder 28.9 COMT DRD2 HTR1A IL6 OXTR SLC6A4
33 alcohol dependence 28.9 ANKK1 COMT DRD2 HTR1A SLC6A4
34 mood disorder 28.9 COMT DRD2 HTR1A IL6 SLC6A4
35 disease of mental health 28.7 COMT DRD2 HTR1A IL6 OXTR SLC6A4
36 attention deficit-hyperactivity disorder 28.7 ANKK1 COMT DRD2 HTR1A SLC6A4
37 social emotional agnosia 11.1
38 depression 10.7
39 autism 10.4
40 alcohol-induced mental disorder 10.4 DRD2 SLC6A4
41 alcoholic psychosis 10.3 DRD2 SLC6A4
42 schizophreniform disorder 10.3 COMT DRD2
43 polysubstance abuse 10.3 COMT DRD2
44 tardive dyskinesia 10.3 COMT DRD2
45 pain - chronic 10.3
46 opioid addiction 10.3 COMT DRD2
47 anorexia nervosa 10.3
48 psoriasis 10.3
49 impulse control disorder 10.3 ANKK1 DRD2
50 schizophrenia 10.3

Graphical network of the top 20 diseases related to Alexithymia:



Diseases related to Alexithymia

Symptoms & Phenotypes for Alexithymia

MGI Mouse Phenotypes related to Alexithymia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.43 COMT DRD2 IL4 IL6 OXTR SLC6A4
2 nervous system MP:0003631 9.17 COMT DRD2 HTR1A IL4 IL6 OXTR

Drugs & Therapeutics for Alexithymia

Drugs for Alexithymia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 72)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cycloserine Approved Phase 4 68-41-7 401 6234
2
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
3
Sertraline Approved Phase 4 79617-96-2 68617
4 Antidepressive Agents Phase 4
5 Central Nervous System Depressants Phase 4,Phase 2,Not Applicable
6 Peripheral Nervous System Agents Phase 4
7 Anti-Bacterial Agents Phase 4
8 Excitatory Amino Acid Antagonists Phase 4
9 Antimetabolites Phase 4
10 Anti-Infective Agents Phase 4,Phase 1,Not Applicable
11 Neurotransmitter Agents Phase 4,Phase 2
12 Anesthetics Phase 4
13 Anesthetics, Dissociative Phase 4
14 Anesthetics, Intravenous Phase 4
15 Antibiotics, Antitubercular Phase 4
16 Anti-Infective Agents, Urinary Phase 4
17 Antitubercular Agents Phase 4
18 Analgesics Phase 4
19 Anesthetics, General Phase 4
20 Renal Agents Phase 4
21 Excitatory Amino Acids Phase 4
22 Serotonin Agents Phase 4,Phase 2
23 Serotonin Uptake Inhibitors Phase 4
24 Psychotropic Drugs Phase 4,Phase 2,Not Applicable
25 Neurotransmitter Uptake Inhibitors Phase 4,Phase 2
26
Serotonin Investigational, Nutraceutical Phase 4,Phase 2 50-67-9 5202
27
Oxytocin Approved, Vet_approved Phase 2,Not Applicable 50-56-6 439302 53477758
28
Zopiclone Approved Phase 2 43200-80-2 5735
29
3,4-Methylenedioxyamphetamine Experimental, Illicit Phase 2 4764-17-4 1614
30 Oxytocics Phase 2,Not Applicable
31 Hypnotics and Sedatives Phase 2
32 N-Methyl-3,4-methylenedioxyamphetamine Phase 2
33 Adrenergic Agents Phase 2
34 Hallucinogens Phase 2
35
Acetylcysteine Approved, Investigational Phase 1 616-91-1 12035
36 Vitamins Phase 1
37 Free Radical Scavengers Phase 1
38 Antidotes Phase 1
39 Antiviral Agents Phase 1
40 N-monoacetylcystine Phase 1
41 Expectorants Phase 1
42 Antioxidants Phase 1
43 Respiratory System Agents Phase 1
44 Protective Agents Phase 1
45
Hydrocortisone Approved, Vet_approved 50-23-7 5754
46
Hydrocortisone acetate Approved, Vet_approved 50-03-3
47
Dopamine Approved 62-31-7, 51-61-6 681
48
Norepinephrine Approved 51-41-2 439260
49
Cocaine Approved, Illicit 50-36-2 446220 5760
50
Ethanol Approved Not Applicable 64-17-5 702

Interventional clinical trials:

(show top 50) (show all 69)
# Name Status NCT ID Phase Drugs
1 D-cycloserine for Relapse Prevention Following Intravenous Ketamine in Treatment-resistant Depression Unknown status NCT02772211 Phase 4 Ketamine;D-cycloserine;Placebo
2 Cognitive Behavioral Therapy Versus Sertraline in the Treatment of Post-Traumatic Stress Disorder Completed NCT00391430 Phase 4 Sertraline
3 Autism Oxytocin Brain Project Completed NCT03033784 Phase 2 Oxytocin;Oxytocin;Oxytocin;Placebo
4 Impact of a Group Intervention on Breast Cancer Patient's Adjustment and Emotion Regulation at the End of Treatment Completed NCT01797354 Phase 2
5 Ocytocine and Cerebral Activation in Relation With Attachement Recruiting NCT02847143 Phase 2 nasal oxytocin or placebo
6 Effectiveness of BBT-I and Zopiclone for Chronic Insomnia Completed NCT03339583 Phase 2 Zopiclone
7 MDMA-assisted Therapy for Social Anxiety in Autistic Adults Completed NCT02008396 Phase 2 Placebo;MDMA
8 Pain and Stress Management for Fibromyalgia Completed NCT01287481 Phase 2
9 Early Study of N-Acetylcysteine to Treat Deliberate Self-Harm in Adolescents Completed NCT01111734 Phase 1 fMRI
10 Neurobiological, Neuropsychological,Linguistic and Gestural Processes and Phenomena in Individuals With Alexithymia Unknown status NCT00830752
11 Psychopathological Risk Factors Associated With Conversion From Mild Cognitive Impairment to Dementia Unknown status NCT01436552
12 Halifax Treatment Refractory Depression Trial Unknown status NCT01141426 Not Applicable
13 Alexithymia Frequency and Interhemispheric Transfer in Patients With a First Demyelinating Event Completed NCT03796247
14 Evaluation of Art-therapy on Alexithymia in Patients Suffering From Anorexia Nervosa and From Bulimia Not yet recruiting NCT03524443
15 Training to Reconnect With Emotional Awareness Therapy Recruiting NCT03414463 Not Applicable
16 The Emotion Builder: An Intervention for Emotional Deficits After Brain Injury Completed NCT02432300 Not Applicable
17 Online Treatment of Trichotillomania Completed NCT02044237 Not Applicable
18 Clinical Assessment and Psychosocial Impact of Psoriasis Completed NCT01964443
19 Psychological Variables and Hyperglycemia in Diabetes Mellitus Withdrawn NCT01714986 Not Applicable
20 Asthma, Smoking, Emotional Deficits Not yet recruiting NCT03312673
21 Outcomes of Mentalization-Based Treatment for Borderline Personality Disorder Completed NCT03295838 Not Applicable
22 Psychological Impact in Diabetes: Intervention With Affect School and Basal Body Awareness Terminated NCT01498614 Not Applicable
23 Positive Emotion Regulation Training in Children, Adolescents and Young Adults With and Without Developmental Disorder Recruiting NCT02898298 Not Applicable
24 Evaluation of Smell and Taste in Fibromyalgia Recruiting NCT03823937
25 Emotion Regulation Group Skills Training for Adolescents and Parents Recruiting NCT03900533 Not Applicable
26 Moderating Impact of Various Emotion Personality Factors on Salivary Cortisol Response to a TSST Completed NCT00451126
27 Effectiveness of Standard Emergency Department Psychiatric Treatment Associated With Treatment Delivery by a Suicide Prevention Center Completed NCT00641498 Not Applicable
28 The Neural Bases of Emotion Regulation in Bulimia Nervosa Not yet recruiting NCT03781921
29 Attention Bias Modification Treatment for Warzone-Related Posttraumatic Stress Disorder (PTSD) Completed NCT01564667 Not Applicable
30 Service Member Fatigue and Lack of Motivation Following Concussion Completed NCT01496586
31 Functional Neuroanatomy and Regional Metabolism Before and After Treatment With Duloxetine Completed NCT02658617
32 Development of Reward Processing in Prenatally Exposed Adolescents and Young Adults Enrolling by invitation NCT03268759
33 Automated Assessment Using Facial Coding Not yet recruiting NCT03551886 Not Applicable
34 Research Project About Psychological Strain, Quality of Life and Emotional Awareness in Patients With Tinnitus Completed NCT01837368
35 A SYNdemic BASed INtervention for MSM With High Risk Behavior: Design of a Randomized Controlled Trial Completed NCT02859935 Not Applicable
36 Effects of Prenatal Alcohol Exposure on Emotional and Cognitive Abilities in Adults Active, not recruiting NCT03793920 Not Applicable
37 Re-nutrition in Severe Anorexia Nervosa Recruiting NCT02502617
38 Depression Online Assessment and Therapy Completed NCT02112266 Not Applicable
39 Mindfulness in Preparation to Bariatric Surgery Completed NCT02854306 Not Applicable
40 CBT-Eb Plus EMDR Versus CBT-Eb in Patients With Eating Disorders Recruiting NCT03156959 Not Applicable
41 Childhood Trauma in Schizophrenia: Exploration of Links Between Gene Expression, Cerebral Morphology and Symptomatology Recruiting NCT03355781
42 the Effects of Oxytocin on Negative Symptoms and Cognitive Tasks in Schizophrenia and it's Possible Mechanisms. Not yet recruiting NCT03662425 Not Applicable Oxytocin;Saline;Oxytocin;Saline
43 Psychological Predictors in Colorectal Cancer Surgery Recovery Recruiting NCT03781193
44 Neuropsychiatric Mechanisms of Change in Mentalization Based Treatment of Borderline Personality Disorder (MENTAB) Terminated NCT01720953
45 The Effectiveness of Mindfulness on Chronic Pain in Breast Cancer Survivors Completed NCT01674881 Not Applicable
46 Electrophysiological Correlates of Emotional and Crossmodal Stimuli Processing Among Alcohol-dependent Participants Completed NCT01633905
47 Emotional Dysregulation in Para-suicidal Behavior Recruiting NCT03846375 Not Applicable
48 Extreme Challenges - Psychopathology & Treatment Experiences Among Severly Selfharming Inpatients in Norway Not yet recruiting NCT03768674
49 Effects of a Motor Imagery Exercise Protocol in Patients With Fibromyalgia Completed NCT03870932 Not Applicable
50 Socio-psychological Factors Involved in the Hematopoietic Stem Cell Transplantation Process in People With Hemopathies Active, not recruiting NCT03883672 Not Applicable

Search NIH Clinical Center for Alexithymia

Genetic Tests for Alexithymia

Anatomical Context for Alexithymia

MalaCards organs/tissues related to Alexithymia:

42
Brain, Testes, Breast, Heart, Eye, Kidney, Cortex

Publications for Alexithymia

Articles related to Alexithymia:

(show top 50) (show all 1562)
# Title Authors Year
1
Factorial Validity of the Toronto Alexithymia Scale (TAS-20) in Clinical Samples: A Critical Examination of the Literature and a Psychometric Study in Anorexia Nervosa. ( 29603033 )
2019
2
Duration of breastfeeding is associated with emotional eating through its effect on alexithymia in boys, but not girls. ( 30315844 )
2019
3
Fearful Attachment Linked to Childhood Abuse, Alexithymia, and Depression in Motor Functional Neurological Disorders. ( 30376786 )
2019
4
Investigating alexithymia in autism: A systematic review and meta-analysis. ( 30399531 )
2019
5
Internet gaming disorder in male and female young adults: The role of alexithymia, depression, anxiety and gaming type. ( 30616119 )
2019
6
The role of alexithymia in parent-child interaction and in the emotional ability of children with autism spectrum disorder. ( 30624024 )
2019
7
Alexithymia predicts poorer social and everyday functioning in schizophrenia and bipolar disorder. ( 30658205 )
2019
8
Toronto Alexithymia Scale-20: Examining 18 Competing Factor Structure Solutions in a U.S. Sample and a Philippines Sample. ( 30661362 )
2019
9
Evaluation of alexithymia in patients affected by rheumatoid arthritis and psoriatic arthritis: A cross-sectional study. ( 30681555 )
2019
10
The role of alexithymia in trauma therapy outcomes: Examining improvements in PTSD, dissociation, and interpersonal problems. ( 30688506 )
2019
11
5-HTTLPR and COMT Val158Met are not associated with alexithymia: New evidence and meta-analyses. ( 30707988 )
2019
12
Alexithymia and psoriasis: what is the link? ( 30714112 )
2019
13
Alexithymia and frontal-amygdala functional connectivity in North Korean refugees. ( 30744720 )
2019
14
Alexithymia is associated with neural reactivity to masked emotional faces in adolescents who self-harm. ( 30780118 )
2019
15
The impact of Balint work on alexithymia, perceived stress, perceived social support and burnout among physicians working in palliative care: a longitudinal study. ( 30785127 )
2019
16
Separate contributions of autistic traits and anxious apprehension, but not alexithymia, to emotion processing in faces. ( 30848668 )
2019
17
Parental bonding, adult attachment, and theory of mind: A developmental model of alexithymia and alcohol-related risk. ( 30848836 )
2019
18
Alexithymia Predicts Cognitive Deficits In Patients With Idiopathic Parkinson's Disease. ( 30868777 )
2019
19
Alexithymia Predicts Cognitive Deficits In Patients With Idiopathic Parkinson's Disease. ( 30868778 )
2019
20
A Comparison Among the Prevalence of Alexithymia in Patients With Psychogenic Nonepileptic Seizures, Epilepsy, and the Healthy Population: A Systematic Review of the Literature. ( 30876655 )
2019
21
Alexithymia in HIV, HCV and coinfections. ( 30882378 )
2019
22
Alexithymia, Suicide Ideation and Homocysteine Levels in Drug Naïve Patients with Major Depression: A Study in the “Real World” Clinical Practice. ( 30905133 )
2019
23
Does emotion matter? The role of alexithymia in violent recidivism: A systematic literature review. ( 30916846 )
2019
24
Alexithymia and weight loss in obese patients underwent laparoscopic sleeve gastrectomy. ( 28353096 )
2019
25
Attachment avoidance, alexithymia, and gender: Examining their associations with distress disclosure tendencies and event-specific disclosure. ( 29355345 )
2018
26
Is alexithymia characterised by impaired interoception? Further evidence, the importance of control variables, and the problems with the Heartbeat Counting Task. ( 29803614 )
2018
27
Body talk: Sex differences in the influence of alexithymia on physical complaints among psychiatric outpatients. ( 29309955 )
2018
28
Affect labeling and other aspects of emotional experiences in relation to alexithymia following standardized emotion inductions. ( 29428774 )
2018
29
Childhood Trauma and Functional Variants of 5-HTTLPR Are Independently Associated with Alexithymia in 5,283 Subjects from the General Population. ( 29306941 )
2018
30
Psychoeducation against depression, anxiety, alexithymia and fibromyalgia: a pilot study in primary care for patients on sick leave. ( 29693478 )
2018
31
The functional and structural characteristics of the emotion network in alexithymia. ( 29695908 )
2018
32
Alexithymia and autistic traits as possible predictors for traits related to depression, anxiety, and stress: A multivariate statistical approach. ( 29882629 )
2018
33
Subjective and Objective: Alexithymia and Social Cognition in Eating Disorders. ( 29916406 )
2018
34
Psychometric Properties of the Bermond-Vorst Alexithymia Questionnaire (BVAQ) in the General Population and a Clinical Population. ( 29740350 )
2018
35
Association of Internet addiction and alexithymia - A scoping review. ( 29429757 )
2018
36
Alexithymia as a potential source of symptom over-reporting: An exploratory study in forensic patients and non-forensic participants. ( 29349809 )
2018
37
Are alexithymia and empathy predicting factors of the resilience of medical residents in France? ( 29731450 )
2018
38
Headache and Alexithymia in Children and Adolescents: What Is the Connection? ( 29449820 )
2018
39
Association Between Alexithymia and Functional Gastrointestinal Disorders. ( 29922191 )
2018
40
Do terrorists suffer from alexithymia? ( 29417660 )
2018
41
The influence of alexithymia on mobile phone addiction: The role of depression, anxiety and stress. ( 28926906 )
2018
42
Language and alexithymia: Evidence for the role of the inferior frontal gyrus in acquired alexithymia. ( 29360519 )
2018
43
Alexithymia and Somatosensory Amplification Link Perceived Psychosocial Stress and Somatic Symptoms in Outpatients with Psychosomatic Illness. ( 29748483 )
2018
44
Symptom, alexithymia and self-image outcomes of Mentalisation-based treatment for borderline personality disorder: a naturalistic study. ( 29890960 )
2018
45
Assessing advanced theory of mind and alexithymia in patients suffering from enduring borderline personality disorder. ( 29360051 )
2018
46
The Relationship Between Alexithymia and Emotional Awareness: A Meta-Analytic Review of the Correlation Between TAS-20 and LEAS. ( 29713295 )
2018
47
Bullying and alexithymia: Are there differences between traditional, cyber, combined bullies, and nonbullies in reading their own emotions? ( 29952143 )
2018
48
The Impact of Alexithymia on Emotion Dysregulation in Anorexia Nervosa and Bulimia Nervosa over Time. ( 29266572 )
2018
49
The relationship between alexithymia and headache impact: the role of somatization and pain catastrophizing. ( 29869297 )
2018
50
Influence of anxiety and alexithymia on brain activations associated with the perception of others' pain in autism. ( 29683406 )
2018

Variations for Alexithymia

Expression for Alexithymia

Search GEO for disease gene expression data for Alexithymia.

Pathways for Alexithymia

GO Terms for Alexithymia

Biological processes related to Alexithymia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.56 CRP IL4 IL6 SLC6A4
2 response to cocaine GO:0042220 9.46 DRD2 OXTR
3 acute-phase response GO:0006953 9.43 CRP IL6
4 response to amphetamine GO:0001975 9.4 DRD2 OXTR
5 vasoconstriction GO:0042310 9.37 HTR1A SLC6A4
6 dopamine metabolic process GO:0042417 9.32 COMT DRD2
7 response to drug GO:0042493 9.26 COMT DRD2 OXTR SLC6A4
8 negative regulation of lipid storage GO:0010888 9.16 CRP IL6
9 sperm ejaculation GO:0042713 8.62 OXTR SLC6A4

Molecular functions related to Alexithymia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serotonin binding GO:0051378 8.62 HTR1A SLC6A4

Sources for Alexithymia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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