Alexithymia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ALX002 MIFTS: 41	Alexithymia Categories: Mental diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Alexithymia

MalaCards integrated aliases for Alexithymia:

Name: Alexithymia ¹² ¹⁵

Classifications:

MalaCards categories:
Anatomical: Mental diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060131

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Summaries for Alexithymia

Disease Ontology : ¹² An agnosia that is a deficiency in understanding, processing, or describing emotions.

MalaCards based summary : Alexithymia is related to anxiety and eating disorder. An important gene associated with Alexithymia is ANKK1 (Ankyrin Repeat And Kinase Domain Containing 1), and among its related pathways/superpathways are cAMP signaling pathway and Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics. The drugs Cycloserine and Ketamine have been mentioned in the context of this disorder. Affiliated tissues include brain, breast and testes, and related phenotypes are cardiovascular system and endocrine/exocrine gland

Wikipedia : ⁷⁶ Alexithymia /�?eɪl�?ks�?�?θaɪmi�?/ is a personality construct characterized by the subclinical inability... more...

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Related Diseases for Alexithymia

Diseases related to Alexithymia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 185)

#	Related Disease	Score	Top Affiliating Genes
1	anxiety	30.8	COMT HTR1A SLC6A4
2	eating disorder	30.7	COMT DRD2 SLC6A4
3	fibromyalgia	30.7	COMT SLC6A4
4	traumatic brain injury	30.6	COMT DRD2
5	brain injury	30.6	COMT DRD2
6	somatoform disorder	30.4	COMT IL4
7	pathological gambling	30.2	DRD2 SLC6A4
8	panic disorder	30.2	COMT HTR1A SLC6A4
9	borderline personality disorder	30.2	COMT HTR1A SLC6A4
10	post-traumatic stress disorder	30.0	COMT CRP DRD2 SLC6A4
11	personality disorder	30.0	ANKK1 COMT DRD2 HTR1A SLC6A4
12	autism	30.0	COMT DRD2 HTR1A OXTR SLC6A4
13	schizophrenia	29.9	COMT DRD2 HTR1A SLC6A4
14	alcohol abuse	29.8	ANKK1 DRD2 SLC6A4
15	paranoid schizophrenia	29.8	COMT SLC6A4
16	obsessive-compulsive disorder	29.8	COMT DRD2 HTR1A OXTR SLC6A4
17	chronic fatigue syndrome	29.7	COMT HTR1A SLC6A4
18	dyspepsia	29.7	HTR1A SLC6A4
19	major depressive disorder	29.6	COMT DRD2 HTR1A OXTR SLC6A4
20	social phobia	29.6	DRD2 HTR1A SLC6A4
21	generalized anxiety disorder	29.6	COMT DRD2 HTR1A SLC6A4
22	mood disorder	29.4	COMT DRD2 HTR1A SLC6A4
23	antisocial personality disorder	29.4	ANKK1 COMT DRD2 SLC6A4
24	premature ejaculation	29.4	COMT HTR1A SLC6A4
25	migraine without aura	29.4	DRD2 HTR1A SLC6A4
26	psychotic disorder	29.2	COMT DRD2 HTR1A SLC6A4
27	migraine with or without aura 1	29.2	COMT DRD2 HTR1A SLC6A4
28	parkinson disease, late-onset	29.2	COMT DRD2 HTR1A SLC6A4
29	bipolar disorder	29.2	COMT DRD2 HTR1A SLC6A4
30	alcohol dependence	29.0	ANKK1 COMT DRD2 HTR1A SLC6A4
31	attention deficit-hyperactivity disorder	29.0	ANKK1 COMT DRD2 HTR1A SLC6A4
32	disease of mental health	28.9	COMT DRD2 HTR1A OXTR SLC6A4
33	social emotional agnosia	11.1
34	depression	10.7
35	anorexia nervosa	10.2
36	pain - chronic	10.2
37	alcohol-induced mental disorder	10.2	DRD2 SLC6A4
38	schizophreniform disorder	10.2	COMT DRD2
39	alcoholic psychosis	10.2	DRD2 SLC6A4
40	polysubstance abuse	10.2	COMT DRD2
41	tardive dyskinesia	10.2	COMT DRD2
42	opioid addiction	10.2	COMT DRD2
43	opiate dependence	10.2	DRD2 SLC6A4
44	autism spectrum disorder	10.1
45	psoriasis	10.1
46	impulse control disorder	10.1	ANKK1 DRD2
47	cocaine abuse	10.1	DRD2 SLC6A4
48	taqi polymorphism	10.1	ANKK1 DRD2
49	heroin dependence	10.1	ANKK1 DRD2
50	mycoplasma pneumoniae pneumonia	10.1	CRP IL4

Graphical network of the top 20 diseases related to Alexithymia:

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Symptoms & Phenotypes for Alexithymia

MGI Mouse Phenotypes related to Alexithymia:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	9.43	ABCB4 COMT CRP DRD2 HTR1A SLC6A4
2	endocrine/exocrine gland	MP:0005379	9.1	ABCB4 COMT DRD2 IL4 OXTR SLC6A4

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Drugs & Therapeutics for Alexithymia

Drugs for Alexithymia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 64)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Cycloserine

Approved

Phase 4

68-41-7

6234 401

Ketamine

Approved, Vet_approved

Phase 4

6740-88-1

3821

Sertraline

Approved

Phase 4

79617-96-2

68617

Antitubercular Agents

Phase 4

Anti-Infective Agents

Phase 4,Phase 1

Central Nervous System Depressants

Phase 4,Phase 2

Neurotransmitter Agents

Phase 4,Phase 2

Anti-Infective Agents, Urinary

Phase 4

Anesthetics, Dissociative

Phase 4

Antidepressive Agents

Phase 4

Anti-Bacterial Agents

Phase 4

Excitatory Amino Acids

Phase 4

Analgesics

Phase 4

Excitatory Amino Acid Antagonists

Phase 4

Antibiotics, Antitubercular

Phase 4

Peripheral Nervous System Agents

Phase 4

Antimetabolites

Phase 4

Renal Agents

Phase 4

Anesthetics, Intravenous

Phase 4

Anesthetics

Phase 4

Anesthetics, General

Phase 4

Serotonin Uptake Inhibitors

Phase 4

Serotonin Agents

Phase 4,Phase 2

Psychotropic Drugs

Phase 4,Phase 2,Not Applicable

Neurotransmitter Uptake Inhibitors

Phase 4,Phase 2

Serotonin

Investigational, Nutraceutical

Phase 4,Phase 2

50-67-9

5202

Oxytocin

Approved, Vet_approved

Phase 2,Not Applicable

50-56-6

439302 53477758

Zopiclone

Approved

Phase 2

43200-80-2

5735

3,4-Methylenedioxyamphetamine

Experimental, Illicit

Phase 2

4764-17-4

1614

Oxytocics

Phase 2,Not Applicable

Hypnotics and Sedatives

Phase 2

N-Methyl-3,4-methylenedioxyamphetamine

Phase 2

Adrenergic Agents

Phase 2

Hallucinogens

Phase 2

Acetylcysteine

Approved, Investigational

Phase 1

616-91-1

12035

Antiviral Agents

Phase 1

Vitamins

Phase 1

Antioxidants

Phase 1

Respiratory System Agents

Phase 1

Antidotes

Phase 1

Expectorants

Phase 1

Free Radical Scavengers

Phase 1

Protective Agents

Phase 1

N-monoacetylcystine

Phase 1

Hydrocortisone

Approved, Vet_approved

50-23-7

5754

Hydrocortisone acetate

Approved, Vet_approved

50-03-3

Dopamine

Approved

51-61-6, 62-31-7

681

Norepinephrine

Approved

51-41-2

439260

Ethanol

Approved

64-17-5

702

Zinc oxide

Approved

Not Applicable

1314-13-2

Interventional clinical trials:

(show top 50) (show all 63)

#	Name	Status	NCT ID	Phase	Drugs
1	D-cycloserine for Relapse Prevention Following Intravenous Ketamine in Treatment-resistant Depression	Unknown status	NCT02772211	Phase 4	Ketamine;D-cycloserine;Placebo
2	Cognitive Behavioral Therapy Versus Sertraline in the Treatment of Post-Traumatic Stress Disorder	Completed	NCT00391430	Phase 4	Sertraline
3	Autism Oxytocin Brain Project	Completed	NCT03033784	Phase 2	Oxytocin;Oxytocin;Oxytocin;Placebo
4	Impact of a Group Intervention on Breast Cancer Patient's Adjustment and Emotion Regulation at the End of Treatment	Completed	NCT01797354	Phase 2
5	Effectiveness of BBT-I and Zopiclone for Chronic Insomnia	Completed	NCT03339583	Phase 2	Zopiclone
6	MDMA-assisted Therapy for Social Anxiety in Autistic Adults	Completed	NCT02008396	Phase 2	Placebo;MDMA
7	Pain and Stress Management for Fibromyalgia	Completed	NCT01287481	Phase 2
8	Ocytocine and Cerebral Activation in Relation With Attachement	Recruiting	NCT02847143	Phase 2	nasal oxytocin or placebo
9	Early Study of N-Acetylcysteine to Treat Deliberate Self-Harm in Adolescents	Completed	NCT01111734	Phase 1	fMRI
10	Neurobiological, Neuropsychological,Linguistic and Gestural Processes and Phenomena in Individuals With Alexithymia	Unknown status	NCT00830752
11	Psychopathological Risk Factors Associated With Conversion From Mild Cognitive Impairment to Dementia	Unknown status	NCT01436552
12	Halifax Treatment Refractory Depression Trial	Unknown status	NCT01141426	Not Applicable
13	Alexithymia Frequency and Interhemispheric Transfer in Patients With a First Demyelinating Event	Completed	NCT03796247
14	The Emotion Builder: An Intervention for Emotional Deficits After Brain Injury	Completed	NCT02432300	Not Applicable
15	Online Treatment of Trichotillomania	Completed	NCT02044237	Not Applicable
16	Clinical Assessment and Psychosocial Impact of Psoriasis	Completed	NCT01964443
17	Outcomes of Mentalization-Based Treatment for Borderline Personality Disorder	Completed	NCT03295838	Not Applicable
18	Moderating Impact of Various Emotion Personality Factors on Salivary Cortisol Response to a TSST	Completed	NCT00451126
19	Effectiveness of Standard Emergency Department Psychiatric Treatment Associated With Treatment Delivery by a Suicide Prevention Center	Completed	NCT00641498	Not Applicable
20	Attention Bias Modification Treatment for Warzone-Related Posttraumatic Stress Disorder (PTSD)	Completed	NCT01564667	Not Applicable
21	Service Member Fatigue and Lack of Motivation Following Concussion	Completed	NCT01496586
22	Functional Neuroanatomy and Regional Metabolism Before and After Treatment With Duloxetine	Completed	NCT02658617
23	Research Project About Psychological Strain, Quality of Life and Emotional Awareness in Patients With Tinnitus	Completed	NCT01837368
24	A SYNdemic BASed INtervention for MSM With High Risk Behavior: Design of a Randomized Controlled Trial	Completed	NCT02859935	Not Applicable
25	Depression Online Assessment and Therapy	Completed	NCT02112266	Not Applicable
26	Mindfulness in Preparation to Bariatric Surgery	Completed	NCT02854306	Not Applicable
27	The Effectiveness of Mindfulness on Chronic Pain in Breast Cancer Survivors	Completed	NCT01674881	Not Applicable
28	Electrophysiological Correlates of Emotional and Crossmodal Stimuli Processing Among Alcohol-dependent Participants	Completed	NCT01633905
29	Plasticity of the Compassionate Brain	Completed	NCT01833104	Not Applicable
30	Oculomotor Markers and Attachment in Adolescents	Completed	NCT02851810	Not Applicable
31	Stress Management for Irritable Bowel Syndrome	Completed	NCT01886027	Not Applicable
32	Mindfulness for Irritable Bowel Syndrome	Completed	NCT02794376	Not Applicable
33	Improving Happiness in Flanders	Completed	NCT02041741	Not Applicable
34	Chronic Low Back Pain: A Multidisciplinary Approach	Completed	NCT01993355	Not Applicable
35	Training to Reconnect With Emotional Awareness Therapy	Recruiting	NCT03414463	Not Applicable
36	Positive Emotion Regulation Training in Children, Adolescents and Young Adults With and Without Developmental Disorder	Recruiting	NCT02898298	Not Applicable
37	Re-nutrition in Severe Anorexia Nervosa	Recruiting	NCT02502617
38	CBT-Eb Plus EMDR Versus CBT-Eb in Patients With Eating Disorders	Recruiting	NCT03156959	Not Applicable
39	Childhood Trauma in Schizophrenia: Exploration of Links Between Gene Expression, Cerebral Morphology and Symptomatology	Recruiting	NCT03355781
40	Psychological Predictors in Colorectal Cancer Surgery Recovery	Recruiting	NCT03781193
41	Influence of Main Psychological and Social Factors on Primary Headaches	Recruiting	NCT03577548
42	Student Outcomes of Integrative Mental Health Services	Recruiting	NCT02877875	Not Applicable
43	Olfactory Training and Emotional State	Recruiting	NCT03605524	Not Applicable
44	Can Cognitive Training Decrease Reactive Aggression?	Recruiting	NCT03623477	Not Applicable
45	Randomized Controlled Study of the Efficacy of Hypnosis Versus Relaxation and Control in Neuropathic Pain	Recruiting	NCT02256371	Not Applicable
46	Family Therapy and Anorexia Nervosa : Which is the Best Approach?	Recruiting	NCT03350594	Not Applicable
47	Improving Emotion Regulation Skills Among Adolescents Attempting to Lose Weight	Recruiting	NCT03393221	Not Applicable
48	Effectiveness of Buprenorphine/Naloxone	Recruiting	NCT02882412
49	Effects of Prenatal Alcohol Exposure on Emotional and Cognitive Abilities in Adults	Active, not recruiting	NCT03793920	Not Applicable
50	Mental Training for CFS Following EBV Infection in Adolescents	Active, not recruiting	NCT02499302	Not Applicable

Search NIH Clinical Center for Alexithymia

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Genetic Tests for Alexithymia

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Anatomical Context for Alexithymia

MalaCards organs/tissues related to Alexithymia:

⁴¹

Brain, Breast, Testes, Heart, Amygdala, Skin, Eye

Sources

Publications for Alexithymia

Articles related to Alexithymia:

(show top 50) (show all 1037)

#	Title	Authors	Year
1	Duration of breastfeeding is associated with emotional eating through its effect on alexithymia in boys, but not girls. ( 30315844 )	van Strien T...Winkens LHH	2019
2	Attachment avoidance, alexithymia, and gender: Examining their associations with distress disclosure tendencies and event-specific disclosure. ( 29355345 )	O'Loughlin J.I....Wu A.D.	2018
3	Is alexithymia characterised by impaired interoception? Further evidence, the importance of control variables, and the problems with the Heartbeat Counting Task. ( 29803614 )	Murphy J....Bird G.	2018
4	Body talk: Sex differences in the influence of alexithymia on physical complaints among psychiatric outpatients. ( 29309955 )	Ogrodniczuk J.S....Abbass A.A.	2018
5	Affect labeling and other aspects of emotional experiences in relation to alexithymia following standardized emotion inductions. ( 29428774 )	Aaron R.V....Park S.	2018
6	Childhood Trauma and Functional Variants of 5-HTTLPR Are Independently Associated with Alexithymia in 5,283 Subjects from the General Population. ( 29306941 )	Terock J....Grabe H.J.	2018
7	Psychoeducation against depression, anxiety, alexithymia and fibromyalgia: a pilot study in primary care for patients on sick leave. ( 29693478 )	Melin E.O....Thulesius H.O.	2018
8	The functional and structural characteristics of the emotion network in alexithymia. ( 29695908 )	Han D....Sun X.	2018
9	Alexithymia and autistic traits as possible predictors for traits related to depression, anxiety, and stress: A multivariate statistical approach. ( 29882629 )	Fietz J....Silani G.	2018
10	Subjective and Objective: Alexithymia and Social Cognition in Eating Disorders. ( 29916406 )	Hason Rozenstein M....Latzer Y.	2018
11	Psychometric Properties of the Bermond-Vorst Alexithymia Questionnaire (BVAQ) in the General Population and a Clinical Population. ( 29740350 )	de Vroege L....van der Feltz-Cornelis C.M.	2018
12	Association of Internet addiction and alexithymia - A scoping review. ( 29429757 )	Mahapatra A....Sharma P.	2018
13	Alexithymia as a potential source of symptom over-reporting: An exploratory study in forensic patients and non-forensic participants. ( 29349809 )	Merckelbach H....A8 Campo J.	2018
14	Are alexithymia and empathy predicting factors of the resilience of medical residents in France? ( 29731450 )	Morice-Ramat A....Guihard G.	2018
15	Headache and Alexithymia in Children and Adolescents: What Is the Connection? ( 29449820 )	Natalucci G....Guidetti V.	2018
16	Association Between Alexithymia and Functional Gastrointestinal Disorders. ( 29922191 )	Kano M....Fukudo S.	2018
17	Do terrorists suffer from alexithymia? ( 29417660 )		2018
18	The influence of alexithymia on mobile phone addiction: The role of depression, anxiety and stress. ( 28926906 )		2018
19	Language and alexithymia: Evidence for the role of the inferior frontal gyrus in acquired alexithymia. ( 29360519 )		2018
20	Alexithymia and Somatosensory Amplification Link Perceived Psychosocial Stress and Somatic Symptoms in Outpatients with Psychosomatic Illness. ( 29748483 )		2018
21	Symptom, alexithymia and self-image outcomes of Mentalisation-based treatment for borderline personality disorder: a naturalistic study. ( 29890960 )		2018
22	Assessing advanced theory of mind and alexithymia in patients suffering from enduring borderline personality disorder. ( 29360051 )		2018
23	The Relationship Between Alexithymia and Emotional Awareness: A Meta-Analytic Review of the Correlation Between TAS-20 and LEAS. ( 29713295 )		2018
24	Bullying and alexithymia: Are there differences between traditional, cyber, combined bullies, and nonbullies in reading their own emotions? ( 29952143 )		2018
25	The Impact of Alexithymia on Emotion Dysregulation in Anorexia Nervosa and Bulimia Nervosa over Time. ( 29266572 )		2018
26	The relationship between alexithymia and headache impact: the role of somatization and pain catastrophizing. ( 29869297 )		2018
27	Influence of anxiety and alexithymia on brain activations associated with the perception of others' pain in autism. ( 29683406 )		2018
28	Psychometric Properties of the 20-Item Toronto Alexithymia Scale in the Chilean Population. ( 29946289 )		2018
29	A scoping review of suicidality and alexithymia: The need to consider interoception. ( 29913380 )		2018
30	Traumatic Experiences, Stressful Events, and Alexithymia in Chronic Migraine With Medication Overuse. ( 29867669 )		2018
31	Looking at the eyes interferes with facial emotion recognition in alexithymia. ( 29792440 )		2018
32	Alexithymia in Young Adults With Substance Use Disorders: Critical Issues About Specificity and Treatment Predictivity. ( 29872408 )		2018
33	Correlations between TSIA and TAS-20 and their relation to self-reported negative affect: A study using a multi-method approach in the assessment of alexithymia in a nonclinical sample from Italy. ( 30261408 )	Montebarocci O...Surcinelli P	2018
34	Reversibility of alexithymia with effective treatment of moderate-to-severe psoriasis: longitudinal data from EPIDEPSO. ( 30269346 )	Sampogna F...Paul C	2018
35	Alexithymia and reactive aggression: The role of the amygdala. ( 30273792 )	Farah T...Schug R	2018
36	The development and evaluation of a brief form of the Normative Male Alexithymia Scale (NMAS-BF). ( 30284847 )	Levant RF...Parent MC	2018
37	The relationship between college students' alexithymia and mobile phone addiction: Testing mediation and moderation effects. ( 30309326 )	Mei S...Li J	2018
38	Alexithymia, Impulsivity, and Reward Sensitivity in Young Adult University Student Children of Alcoholics. ( 30321089 )	Lyvers M...Thorberg FA	2018
39	Alexithymia affects patients with hidradenitis suppurativa. ( 30325328 )	Chiricozzi A...Peris K	2018
40	Alexithymia is associated with aggressive tendencies following traumatic brain injury. ( 30373401 )	Williams C...Howe H	2018
41	Fearful Attachment Linked to Childhood Abuse, Alexithymia, and Depression in Motor Functional Neurological Disorders. ( 30376786 )	Williams B...Perez DL	2018
42	Is it the Taste or the Buzz? Alexithymia, Caffeine, and Emotional Eating. ( 30380968 )	Lyvers M...Thorberg FA	2018
43	Interacting and dissociable effects of alexithymia and depression on empathy. ( 30384283 )	Banzhaf C...Bermpohl F	2018
44	Abnormal Illness Behavior, Alexithymia, Demoralization, and Other Clinically Relevant Psychosocial Syndromes in Kidney Transplant Recipients: A Comparative Study of the Diagnostic Criteria for Psychosomatic Research System versus ICD-10 Psychiatric Nosology. ( 30391961 )	Battaglia Y...Grassi L	2018
45	Body image, personality profiles and alexithymia in patients with polycystic ovary syndrome (PCOS). ( 30398405 )	Scaruffi E...Granieri A	2018
46	Investigating alexithymia in autism: A systematic review and meta-analysis. ( 30399531 )	Kinnaird E...Tchanturia K	2018
47	Somatosensory amplification, health anxiety, and alexithymia in generalized anxiety disorder. ( 30416291 )	Kumar V...Grover S	2018
48	Relationship Between Attachment Style in Adulthood, Alexithymia, and Dissociation in Alcohol Use Disorder Inpatients. Mediational Model. ( 30425669 )	Zdankiewicz-?ciga?a E...?ciga?a DK	2018
49	Alcohol and tobacco use in men: the role of alexithymia and externally oriented thinking style. ( 30427739 )	Kajanoja J...Karlsson H	2018
50	Alexithymia explains increased empathic personal distress in individuals with and without eating disorders. ( 30428774 )	Brewer R...Bird G	2018

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Genes for Alexithymia

Genes related to Alexithymia (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ANKK1	Ankyrin Repeat And Kinase Domain Containing 1	Protein Coding	22.86	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	SLC6A4	Solute Carrier Family 6 Member 4	Protein Coding	22.56	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	DRD2	Dopamine Receptor D2	Protein Coding	22.06	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	COMT	Catechol-O-Methyltransferase	Protein Coding	21.8	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	OXTR	Oxytocin Receptor	Protein Coding	21.79	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	TAS2R38	Taste 2 Receptor Member 38	Protein Coding	21.07	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	CRP	C-Reactive Protein	Protein Coding	20.8	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	HTR1A	5-Hydroxytryptamine Receptor 1A	Protein Coding	20.55	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	IL4	Interleukin 4	Protein Coding	20.41	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	ABCB4	ATP Binding Cassette Subfamily B Member 4	Protein Coding	19.85	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

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Variations for Alexithymia

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Expression for Alexithymia

Search GEO for disease gene expression data for Alexithymia.

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Pathways for Alexithymia

Pathways related to Alexithymia according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	cAMP signaling pathway ³⁷ Show member pathways Hydroxycarboxylic acid-binding receptors ⁶⁶	11.64	DRD2 HTR1A OXTR
2	Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics ⁶¹	10.4	HTR1A SLC6A4
3	Neurotransmitter Clearance In The Synaptic Cleft ⁶⁶ Show member pathways Dopamine clearance from the synaptic cleft ⁶⁶ Enzymatic degradation of dopamine by COMT ⁶⁶ Enzymatic degradation of Dopamine by monoamine oxidase ⁶⁶ L-dopa degradation ¹ Metabolism of serotonin ⁶⁶ Serotonin clearance from the synaptic cleft ⁶⁶	10.04	COMT SLC6A4

Sources

GO Terms for Alexithymia

Cellular components related to Alexithymia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	integral component of plasma membrane	GO:0005887	9.02	ABCB4 DRD2 HTR1A OXTR SLC6A4
2	integral component of postsynaptic membrane	GO:0099055	8.96	DRD2 SLC6A4

Biological processes related to Alexithymia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	social behavior	GO:0035176	9.4	OXTR SLC6A4
2	response to cocaine	GO:0042220	9.37	DRD2 OXTR
3	response to amphetamine	GO:0001975	9.32	DRD2 OXTR
4	vasoconstriction	GO:0042310	9.26	HTR1A SLC6A4
5	dopamine metabolic process	GO:0042417	9.16	COMT DRD2
6	response to drug	GO:0042493	9.02	ABCB4 COMT DRD2 OXTR SLC6A4
7	sperm ejaculation	GO:0042713	8.96	OXTR SLC6A4

Molecular functions related to Alexithymia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	G protein-coupled receptor activity	GO:0004930	9.26	DRD2 HTR1A OXTR TAS2R38
2	serotonin binding	GO:0051378	8.62	HTR1A SLC6A4

Sources

Sources for Alexithymia

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia