Aliases & Classifications for Alexithymia

MalaCards integrated aliases for Alexithymia:

Name: Alexithymia 12 15


External Ids:

Disease Ontology 12 DOID:0060131

Summaries for Alexithymia

Disease Ontology : 12 An agnosia that is a deficiency in understanding, processing, or describing emotions.

MalaCards based summary : Alexithymia is related to eating disorder and fibromyalgia. An important gene associated with Alexithymia is SLC6A4 (Solute Carrier Family 6 Member 4), and among its related pathways/superpathways are cAMP signaling pathway and IL12-mediated signaling events. The drugs Oxytocin and Ethanol have been mentioned in the context of this disorder. Affiliated tissues include brain, breast and heart.

Wikipedia : 73 Alexithymia is a personality trait characterized by the subclinical inability to identify and describe... more...

Related Diseases for Alexithymia

Diseases related to Alexithymia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 475)
# Related Disease Score Top Affiliating Genes
1 eating disorder 30.9 SLC6A4 OXTR DRD2 COMT ANKK1
2 fibromyalgia 30.8 SLC6A4 IL6 CRP COMT
3 brain injury 30.7 IL6 DRD2 COMT
4 panic disorder 30.7 SLC6A4 HTR1A DRD2 COMT
5 anorexia nervosa 30.7 SLC6A4 OXT HTR1A COMT
6 bulimia nervosa 30.6 SLC6A4 OXT DRD2 COMT
7 alcohol dependence 30.5 SLC6A4 HTR1A DRD2 COMT ANKK1
8 traumatic brain injury 30.5 IL6 DRD2 COMT ANKK1
9 post-traumatic stress disorder 30.5 SLC6A4 OXTR DRD2 CRP COMT CCL4
10 personality disorder 30.5 SLC6A4 OXTR HTR1A DRD2 COMT ANKK1
11 hypochondriasis 30.4 SLC6A4 OXT HTR1A
12 alcohol use disorder 30.4 SLC6A4 HTR1A DRD2 COMT ANKK1
13 borderline personality disorder 30.4 SLC6A4 OXTR HTR1A DRD2 COMT
14 urticaria 30.4 IL6 IL4 CRP
15 somatoform disorder 30.4 SLC6A4 LOC110806262 IL6 IL4 COMT
16 adjustment disorder 30.3 SLC6A4 OXT HTR1A
17 chronic urticaria 30.3 IL6 IL4 CRP
18 somatization disorder 30.3 SLC6A4 OXT IL6 HTR1A COMT
19 bronchitis 30.2 IL6 IL4 CRP
20 migraine without aura 30.2 SLC6A4 HTR1A DRD2
21 acute stress disorder 30.2 SLC6A4 OXT IL6 HTR1A CRP
22 autism 30.1 SLC6A4 OXTR OXT HTR1A DRD2 COMT
23 generalized anxiety disorder 30.1 SLC6A4 HTR1A DRD2 CRP COMT
24 mood disorder 30.1 SLC6A4 IL6 HTR1A DRD2 COMT
25 polysubstance abuse 30.1 DRD2 COMT
26 tobacco addiction 30.1 SLC6A4 DRD2 COMT ANKK1
27 paranoid schizophrenia 30.0 SLC6A4 IL6 HTR1A COMT
28 substance dependence 30.0 SLC6A4 IL6 DRD2 COMT ANKK1
29 cocaine abuse 30.0 SLC6A4 IL6 DRD2
30 sexual disorder 30.0 SLC6A4 OXT HTR1A
31 obsessive-compulsive personality disorder 30.0 SLC6A4 COMT
32 tic disorder 30.0 SLC6A4 DRD2 COMT
33 pathological gambling 30.0 SLC6A4 LOC110806262 HTR1A DRD2 COMT ANKK1
34 atypical depressive disorder 29.9 SLC6A4 IL6 HTR1A CRP
35 cocaine dependence 29.9 SLC6A4 DRD2 COMT
36 irritable bowel syndrome 29.9 SLC6A4 IL6 IL4 HTR1A CRP COMT
37 anxiety 29.9 SLC6A4 OXTR OXT IL6 HTR1A DRD2
38 relapsing-remitting multiple sclerosis 29.8 IL6 IL4 CCL3
39 substance abuse 29.8 SLC6A4 IL6 HTR1A DRD2 CRP COMT
40 migraine with aura 29.8 SLC6A4 LOC110806262 DRD2
41 social phobia 29.8 SLC6A4 OXT LOC110806262 HTR1A DRD2 COMT
42 sleep disorder 29.8 SLC6A4 IL6 HTR1A CRP COMT
43 chronic fatigue syndrome 29.8 SLC6A4 IL6 IL4 HTR1A COMT
44 sleep apnea 29.8 SLC6A4 IL6 CRP
45 hypoactive sexual desire disorder 29.8 OXT HTR1A
46 bipolar disorder 29.7 SLC6A4 IL6 HTR1A DRD2 CRP COMT
47 paraphilia disorder 29.7 SLC6A4 OXT DRD2
48 periodontitis 29.7 IL6 IL4 CRP
49 paine syndrome 29.7 SLC6A4 MIR548D1 IL6 COMT
50 asperger syndrome 29.7 SLC6A4 OXTR OXT COMT

Graphical network of the top 20 diseases related to Alexithymia:

Diseases related to Alexithymia

Symptoms & Phenotypes for Alexithymia

Drugs & Therapeutics for Alexithymia

Drugs for Alexithymia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

# Name Status Phase Clinical Trials Cas Number PubChem Id
Oxytocin Approved, Vet_approved Phase 2 50-56-6 439302 53477758
Ethanol Approved 64-17-5 702
3 Pharmaceutical Solutions

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 A Cross Over Randomized Controlled Trial of the Effect of Nasal Ocytocine on Cerebral Activations in Relation With Attachement in the General Population Unknown status NCT02847143 Phase 2 nasal oxytocin or placebo
2 Understanding Alexithymia Unknown status NCT00830752
3 Evaluation of Art-therapy on Alexithymia in Patients Suffering From Anorexia Nervosa and From Bulimia,a Pilot Study Unknown status NCT03524443
4 Psychological Predictors of Post-surgical Recovery in Colorectal Cancer Patients: a Pilot Cohort Study Unknown status NCT03781193
5 Alexithymia Frequency and Interhemispheric Transfer in Patients With a First Demyelinating Event: Initial Phase of Multiple Sclerosis Completed NCT03796247
6 Alexithymia in Ankylosing Spondylitis Completed NCT04320459
7 Online Assessment for Therapy Expectation and Quality of Life and Online Therapy of Depression Completed NCT02112266
8 Symptom, Alexithymia and Self-image Outcomes of Mentalization-Based Treatment for Borderline Personality Disorder: a Naturalistic Study Completed NCT03295838
9 Oculomotor and Neurophysiological Markers of Emotion Regulation and Attachment Styles in Adolescence Completed NCT02851810
10 Impact of Art Therapy on Alexithymia in People With Alcohol Use Disorder Recruiting NCT04206930
11 Childhood Trauma in Schizophrenia: Exploration of Links Between Gene Expression, Cerebral Morphology and Symptomatology. SCHIZO' TRAUMA Recruiting NCT03355781
12 Training to Reconnect With Emotional Awareness Therapy Recruiting NCT03414463
13 Mitigating Suicide Risk During the COVID-19 Pandemic Via Telehealth Using an Intensive Single Session of "Brief Skills for Safer Living" Recruiting NCT04495543
14 Psychological Impact, Metabolic Control, and Biological Stress Markers in Diabetes: Intervention Study With Affect School and Basal Body Awareness Terminated NCT01498614

Search NIH Clinical Center for Alexithymia

Genetic Tests for Alexithymia

Anatomical Context for Alexithymia

MalaCards organs/tissues related to Alexithymia:

Brain, Breast, Heart, Skin, Eye, Spinal Cord, Amygdala

Publications for Alexithymia

Articles related to Alexithymia:

(show top 50) (show all 3155)
# Title Authors PMID Year
Emotional eating during COVID-19 in the United Kingdom: Exploring the roles of alexithymia and emotion dysregulation. 61
33450300 2021
Increased emotional eating during COVID-19 associated with lockdown, psychological and social distress. 61
33453336 2021
Parent-child interaction, parental attachment styles and parental alexithymia levels of children with ASD. 61
33690111 2021
The impact of sexual abuse on psychopathology of patients with psychogenic nonepileptic seizures. 61
32794127 2021
Negative mood regulation expectancies moderate the effect of childhood maltreatment on compulsive buying. 61
33420747 2021
Alexithymia is associated with increased all-cause mortality risk in men, but not in women: A 10-year follow-up study. 61
33540301 2021
A bifactor analysis of the 20-item Toronto Alexithymia Scale: Further support for a general alexithymia factor. 61
33793263 2021
How Mindfulness and Acceptance Could Help Psychiatrists Predict Alexithymia Among Students. 61
33476108 2021
Interoception moderates the relation between alexithymia and risky-choices in a framing task: A proposal of two-stage model of decision-making. 61
33482229 2021
Associations and interactions of the serotonin receptor genes 5-HT1A, 5-HT2A, and childhood trauma with alexithymia in two independent general-population samples. 61
33567384 2021
The relationship between ambivalence, alexithymia, and salience network dysfunction in schizophrenia. 61
33711658 2021
Preoperative psychological characteristics affecting mid-term outcome after bariatric surgery: a follow-up study. 61
32207099 2021
Distinctive Frontal and Occipitotemporal Surface Features in Neglectful Parenting. 61
33803895 2021
Skin Conductance as an Index of Alexithymic Traits in the General Population. 61
33789537 2021
Motor and non-motor outcomes after a rehabilitation program for patients with Functional Motor Disorders: a prospective, observational cohort study. 61
33780378 2021
Empathy and the ability to experience one's own emotions modify the expression of blatant and subtle prejudice among young male adults. 61
33798974 2021
An analysis of conscious fear and automatic threat response in psychopathy. 61
32658520 2021
Altering sensorimotor simulation impacts early stages of facial expression processing depending on individual differences in alexithymic traits. 61
33454594 2021
Social-emotional functioning in young people with symptoms of eating disorders: A gender inclusive analogue study. 61
33423399 2021
Dysfunctional coping mediates the relationship between stress and mental health in health care staff working amid COVID-19 pandemic. 61
33780942 2021
Impaired Performance in Mental Rotation of Hands and Feet and Its Association with Social Cognition in Patients with Complex Regional Pain Syndrome. 61
33749758 2021
Patient Perspectives of the Social, Emotional and Functional Impact of Alopecia Areata: A Systematic Literature Review. 61
33770385 2021
Alexithymia in multiple sclerosis: Clinical and radiological correlations. 61
32798053 2021
Quality of Life and Psychological Impact in Patients with Atopic Dermatitis. 61
33801061 2021
High levels of physical activity in female adolescents with anorexia nervosa: medical and psychopathological correlates. 61
33704692 2021
Improving the measurement of alexithymia in autistic adults: a psychometric investigation and refinement of the twenty-item Toronto Alexithymia Scale. 61
33653400 2021
No Evidence of Perceptual Pseudoneglect in Alexithymia. 61
33804270 2021
Alexithymia, Affective Lability, Impulsivity, and Childhood Adversity in Borderline Personality Disorder. 61
33650890 2021
Cognitive-emotional processing in alexithymia: an integrative review. 61
33787442 2021
Alexithymia and Autistic Traits as Contributing Factors to Empathy Difficulties in Preadolescent Children. 61
33788077 2021
The effects of alexithymia, experiential avoidance, and childhood sexual abuse on non-suicidal self-injury and suicidal ideation among Chinese college students with a history of childhood sexual abuse. 61
33418378 2021
Mapping alexithymia: Level of emotional awareness differentiates emotion-specific somatosensory maps. 61
33476805 2021
Attachment representations and alexithymia in community adolescents with binge-eating attitudes. 61
32277425 2021
Deficient auditory emotion processing but intact emotional multisensory integration in alexithymia. 61
33742708 2021
Post-traumatic factors are involved in the evolution of the number of seizures in patients with PNES. 61
33423016 2021
The moderating effects of self and other mentalizing on the relationship between distress and disordered eating: A cross-cultural examination. 61
33561313 2021
Gender Differences in Empathy During Adolescence: Does Emotional Self-Awareness Matter? 61
33588646 2021
Processing of emotionally ambiguous stimuli in eating disorders: an fMRI pilot study. 61
33559833 2021
Mediating Factors between Childhood Traumatic Experiences and Eating Disorders Development: A Systematic Review. 61
33561984 2021
Study protocol of a randomised controlled trial on SISU, a software agent providing a brief self-help intervention for adults with low psychological well-being. 61
33558351 2021
Is alexithymia related to retention and relapses in patients with substance use disorders?: A one year follow-up study. 61
33038681 2021
[Relationship between childhood trauma and suicidal risk in prisoners: the mediating effect of alexithymia]. 61
33624606 2021
The Prevalence and Characteristics of Alexithymia in Adults Following Brain Injury: A Meta-Analysis. 61
33624197 2021
Orthorexia nervosa and its association with alexithymia, emotion dysregulation and disordered eating attitudes among Lebanese adults. 61
33570743 2021
In response to Chaturvedi: Professional quality of life, burnout and alexithymia. 61
32871167 2021
Development and psychometric evaluation of an informant form of the 20-item Toronto alexithymia scale. 61
33316631 2021
Professional quality of life, burnout and alexithymia. 61
32871168 2021
Assessing alexithymia in forensic settings: Psychometric properties of the 20-item Toronto Alexithymia Scale among incarcerated adult offenders. 61
33200532 2021
Post-Traumatic Growth among Patients after Living and Cadaveric Donor Kidney Transplantation: The Role of Resilience and Alexithymia. 61
33672136 2021
Alexithymia in nonviolent offenders. 61
33200470 2021

Variations for Alexithymia

Expression for Alexithymia

Search GEO for disease gene expression data for Alexithymia.

Pathways for Alexithymia

Pathways related to Alexithymia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
Show member pathways
11.6 IL4 CCL4 CCL3
3 11.26 IL6 IL4 CCL4 CCL3
4 10.95 IL6 IL4 CCL4 CCL3
5 10.4 IL6 IL4
Show member pathways

GO Terms for Alexithymia

Biological processes related to Alexithymia according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 10.04 TAS2R38 OXTR OXT HTR1A DRD2 CCL4
2 positive regulation of gene expression GO:0010628 9.97 SLC6A4 IL6 IL4 CRP CCL3
3 signal transduction GO:0007165 9.97 TAS2R38 OXTR OXT IL6 IL4 HTR1A
4 response to drug GO:0042493 9.93 SLC6A4 OXTR DRD2 COMT
5 cytokine-mediated signaling pathway GO:0019221 9.92 IL6 IL4 CCL4 CCL3
6 response to estradiol GO:0032355 9.83 SLC6A4 OXTR OXT
7 positive regulation of cold-induced thermogenesis GO:0120162 9.8 OXTR OXT IL4
8 female pregnancy GO:0007565 9.79 OXTR OXT COMT
9 memory GO:0007613 9.77 SLC6A4 OXTR OXT
10 social behavior GO:0035176 9.69 SLC6A4 OXTR OXT
11 eosinophil chemotaxis GO:0048245 9.66 CCL4 CCL3
12 dopamine metabolic process GO:0042417 9.66 DRD2 COMT
13 positive regulation of calcium-mediated signaling GO:0050850 9.65 CCL4 CCL3
14 positive regulation of renal sodium excretion GO:0035815 9.65 OXT DRD2
15 negative regulation by host of viral transcription GO:0043922 9.64 CCL4 CCL3
16 grooming behavior GO:0007625 9.64 OXT DRD2
17 monocyte chemotaxis GO:0002548 9.63 IL6 CCL4 CCL3
18 maternal behavior GO:0042711 9.61 OXTR OXT
19 sleep GO:0030431 9.61 OXTR OXT
20 response to cocaine GO:0042220 9.61 OXTR OXT DRD2
21 regulation of behavior GO:0050795 9.59 HTR1A CCL3
22 negative regulation of lipid storage GO:0010888 9.58 IL6 CRP
23 regulation of sensory perception of pain GO:0051930 9.58 OXT COMT CCL3
24 positive regulation of uterine smooth muscle contraction GO:0070474 9.57 OXTR OXT
25 drinking behavior GO:0042756 9.56 OXT DRD2
26 positive regulation of natural killer cell chemotaxis GO:2000503 9.55 CCL4 CCL3
27 negative regulation of gastric acid secretion GO:0060455 9.54 OXTR OXT
28 response to amphetamine GO:0001975 9.54 OXTR OXT DRD2
29 positive regulation of penile erection GO:0060406 9.52 OXTR OXT
30 positive regulation of norepinephrine secretion GO:0010701 9.48 OXTR OXT
31 response to toxic substance GO:0009636 9.46 SLC6A4 DRD2 CCL4 CCL3
32 regulation of digestive system process GO:0044058 9.26 OXTR OXT
33 vasoconstriction GO:0042310 9.13 SLC6A4 HTR1A CRP
34 sperm ejaculation GO:0042713 8.8 SLC6A4 OXTR OXT

Molecular functions related to Alexithymia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serotonin binding GO:0051378 9.26 SLC6A4 HTR1A
2 cytokine activity GO:0005125 9.26 IL6 IL4 CCL4 CCL3
3 CCR5 chemokine receptor binding GO:0031730 9.16 CCL4 CCL3
4 CCR1 chemokine receptor binding GO:0031726 8.62 CCL4 CCL3

Sources for Alexithymia

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
69 Tocris
71 UMLS via Orphanet
Loading form....