Aliases & Classifications for Alexithymia

MalaCards integrated aliases for Alexithymia:

Name: Alexithymia 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060131

Summaries for Alexithymia

Disease Ontology : 12 An agnosia that is a deficiency in understanding, processing, or describing emotions.

MalaCards based summary : Alexithymia is related to eating disorder and pathological gambling. An important gene associated with Alexithymia is ANKK1 (Ankyrin Repeat And Kinase Domain Containing 1), and among its related pathways/superpathways are Folate Metabolism and Circadian rythm related genes. The drugs Ketamine and Cycloserine have been mentioned in the context of this disorder. Affiliated tissues include brain, breast and testes, and related phenotypes are endocrine/exocrine gland and nervous system

Wikipedia : 76 Alexithymia /ˌeɪlɛksəˈθaɪmiə/ is a personality construct characterized by the subclinical inability to... more...

Related Diseases for Alexithymia

Diseases related to Alexithymia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 207)
# Related Disease Score Top Affiliating Genes
1 eating disorder 30.8 COMT DRD2 SLC6A4
2 pathological gambling 30.7 DRD2 SLC6A4
3 fibromyalgia 30.3 COMT IL6 SLC6A4
4 anxiety 30.3 COMT HTR1A SLC6A4
5 traumatic brain injury 30.2 COMT DRD2 IL6
6 brain injury 30.2 COMT DRD2 IL6
7 opioid addiction 30.2 COMT DRD2
8 paranoid schizophrenia 30.2 COMT SLC6A4
9 substance dependence 30.2 DRD2 IL6 SLC6A4
10 impulse control disorder 30.1 ANKK1 DRD2
11 somatoform disorder 30.0 COMT IL4
12 substance abuse 29.9 COMT DRD2 SLC6A4
13 panic disorder 29.8 COMT HTR1A SLC6A4
14 apnea, obstructive sleep 29.7 CRP IL6
15 borderline personality disorder 29.7 COMT HTR1A SLC6A4
16 alcohol abuse 29.7 ANKK1 DRD2 SLC6A4
17 post-traumatic stress disorder 29.6 COMT CRP DRD2 SLC6A4
18 personality disorder 29.5 COMT DRD2 HTR1A SLC6A4
19 generalized anxiety disorder 29.2 DRD2 HTR1A SLC6A4
20 antisocial personality disorder 29.1 ANKK1 COMT DRD2 SLC6A4
21 obsessive-compulsive disorder 29.1 COMT DRD2 HTR1A SLC6A4
22 premature ejaculation 29.1 COMT HTR1A SLC6A4
23 migraine without aura 29.0 DRD2 HTR1A SLC6A4
24 psychotic disorder 28.5 COMT DRD2 HTR1A SLC6A4
25 alcohol dependence 28.4 ANKK1 COMT DRD2 HTR1A SLC6A4
26 parkinson disease, late-onset 28.4 COMT DRD2 HTR1A SLC6A4
27 bipolar disorder 28.4 COMT DRD2 HTR1A SLC6A4
28 autism 28.3 COMT DRD2 HTR1A OXTR SLC6A4
29 chronic fatigue syndrome 28.2 COMT HTR1A IL6 SLC6A4
30 major depressive disorder 28.1 COMT DRD2 HTR1A IL6 SLC6A4
31 disease of mental health 27.8 COMT DRD2 HTR1A OXTR SLC6A4
32 mood disorder 27.8 COMT DRD2 HTR1A IL6 SLC6A4
33 attention deficit-hyperactivity disorder 27.7 ANKK1 COMT DRD2 HTR1A SLC6A4
34 social emotional agnosia 11.0
35 alcohol-induced mental disorder 10.7 DRD2 SLC6A4
36 schizophreniform disorder 10.7 COMT DRD2
37 alcoholic psychosis 10.7 DRD2 SLC6A4
38 polysubstance abuse 10.7 COMT DRD2
39 tardive dyskinesia 10.7 COMT DRD2
40 bruxism 10.7 DRD2 SLC6A4
41 taqi polymorphism 10.5 ANKK1 DRD2
42 heroin dependence 10.5 ANKK1 DRD2
43 depression 10.5
44 cold agglutinin disease 10.5 CRP IL6
45 cryopyrin-associated periodic syndrome 10.5 CRP IL6
46 cardiogenic shock 10.4 CRP IL6
47 acute cholangitis 10.4 CRP IL6
48 neutrophilia, hereditary 10.4 CRP IL6
49 uremic pruritus 10.4 CRP IL6
50 spinal disease 10.4 CRP IL6

Graphical network of the top 20 diseases related to Alexithymia:



Diseases related to Alexithymia

Symptoms & Phenotypes for Alexithymia

MGI Mouse Phenotypes related to Alexithymia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.43 COMT DRD2 IL4 IL6 OXTR SLC6A4
2 nervous system MP:0003631 9.17 IL6 OXTR SLC6A4 COMT DRD2 HTR1A

Drugs & Therapeutics for Alexithymia

Drugs for Alexithymia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 62)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
2
Cycloserine Approved Phase 4 68-41-7 401 6234
3
Sertraline Approved Phase 4 79617-96-2 68617
4 Analgesics Phase 4
5 Renal Agents Phase 4
6 Central Nervous System Depressants Phase 4,Phase 2
7 Neurotransmitter Agents Phase 4,Phase 2
8 Anesthetics Phase 4
9 Anesthetics, Dissociative Phase 4
10 Anesthetics, General Phase 4
11 Anesthetics, Intravenous Phase 4
12 Peripheral Nervous System Agents Phase 4
13 Anti-Bacterial Agents Phase 4
14 Antibiotics, Antitubercular Phase 4
15 Excitatory Amino Acid Antagonists Phase 4
16 Excitatory Amino Acids Phase 4
17 Antidepressive Agents Phase 4
18 Anti-Infective Agents Phase 4,Phase 1
19 Antitubercular Agents Phase 4
20 Antimetabolites Phase 4
21 Serotonin Agents Phase 4,Phase 2
22 Serotonin Uptake Inhibitors Phase 4
23 Neurotransmitter Uptake Inhibitors Phase 4,Phase 2
24 Psychotropic Drugs Phase 4,Phase 2
25
Serotonin Investigational, Nutraceutical Phase 4,Phase 2 50-67-9 5202
26
Zopiclone Approved Phase 2 43200-80-2 5735
27
Oxytocin Approved, Vet_approved Phase 2 50-56-6 439302 53477758
28
3,4-Methylenedioxyamphetamine Experimental, Illicit Phase 2 4764-17-4 1614
29 Adrenergic Agents Phase 2
30 Hallucinogens Phase 2
31 N-Methyl-3,4-methylenedioxyamphetamine Phase 2
32 Hypnotics and Sedatives Phase 2
33 Oxytocics Phase 2
34
Acetylcysteine Approved, Investigational Phase 1 616-91-1 12035
35 Respiratory System Agents Phase 1
36 N-monoacetylcystine Phase 1
37 Vitamins Phase 1
38 Expectorants Phase 1
39 Antidotes Phase 1
40 Antioxidants Phase 1
41 Protective Agents Phase 1
42 Antiviral Agents Phase 1
43
Hydrocortisone Approved, Vet_approved 50-23-7 5754
44
Dopamine Approved 51-61-6, 62-31-7 681
45
Norepinephrine Approved 51-41-2 439260
46
Ethanol Approved 64-17-5 702
47
Zinc oxide Approved Not Applicable 1314-13-2
48
Buprenorphine Approved, Illicit, Investigational, Vet_approved 52485-79-7 40400 644073
49
Naloxone Approved, Vet_approved 465-65-6 5284596
50
Cocaine Approved, Illicit 50-36-2 5760 446220

Interventional clinical trials:

(show top 50) (show all 53)
# Name Status NCT ID Phase Drugs
1 D-cycloserine for Relapse Prevention Following Intravenous Ketamine in Treatment-resistant Depression Unknown status NCT02772211 Phase 4 Ketamine;D-cycloserine;Placebo
2 Cognitive Behavioral Therapy Versus Sertraline in the Treatment of Post-Traumatic Stress Disorder Completed NCT00391430 Phase 4 Sertraline
3 Impact of a Group Intervention on Breast Cancer Patient's Adjustment and Emotion Regulation at the End of Treatment Completed NCT01797354 Phase 2
4 Effectiveness of BBT-I and Zopiclone for Chronic Insomnia Completed NCT03339583 Phase 2 Zopiclone
5 MDMA-assisted Therapy for Social Anxiety in Autistic Adults Completed NCT02008396 Phase 2 Placebo;MDMA
6 Pain and Stress Management for Fibromyalgia Completed NCT01287481 Phase 2
7 Autism Oxytocin Brain Project Recruiting NCT03033784 Phase 2 Oxytocin;Oxytocin;Oxytocin;Placebo
8 Ocytocine and Cerebral Activation in Relation With Attachement Recruiting NCT02847143 Phase 2 nasal oxytocin or placebo
9 Early Study of N-Acetylcysteine to Treat Deliberate Self-Harm in Adolescents Completed NCT01111734 Phase 1 fMRI
10 Neurobiological, Neuropsychological,Linguistic and Gestural Processes and Phenomena in Individuals With Alexithymia Unknown status NCT00830752
11 Psychological Impact in Diabetes: Intervention With Affect School and Basal Body Awareness Unknown status NCT01498614 Not Applicable
12 Psychopathological Risk Factors Associated With Conversion From Mild Cognitive Impairment to Dementia Unknown status NCT01436552
13 Halifax Treatment Refractory Depression Trial Unknown status NCT01141426 Not Applicable
14 The Emotion Builder: An Intervention for Emotional Deficits After Brain Injury Completed NCT02432300 Not Applicable
15 Online Treatment of Trichotillomania Completed NCT02044237 Not Applicable
16 Clinical Assessment and Psychosocial Impact of Psoriasis Completed NCT01964443
17 Outcomes of Mentalization-Based Treatment for Borderline Personality Disorder Completed NCT03295838 Not Applicable
18 Moderating Impact of Various Emotion Personality Factors on Salivary Cortisol Response to a TSST Completed NCT00451126
19 Effectiveness of Standard Emergency Department Psychiatric Treatment Associated With Treatment Delivery by a Suicide Prevention Center Completed NCT00641498 Not Applicable
20 Attention Bias Modification Treatment for Warzone-Related Posttraumatic Stress Disorder (PTSD) Completed NCT01564667 Not Applicable
21 Service Member Fatigue and Lack of Motivation Following Concussion Completed NCT01496586
22 Functional Neuroanatomy and Regional Metabolism Before and After Treatment With Duloxetine Completed NCT02658617
23 Research Project About Psychological Strain, Quality of Life and Emotional Awareness in Patients With Tinnitus Completed NCT01837368
24 Depression Online Assessment and Therapy Completed NCT02112266 Not Applicable
25 Mindfulness in Preparation to Bariatric Surgery Completed NCT02854306 Not Applicable
26 The Effectiveness of Mindfulness on Chronic Pain in Breast Cancer Survivors Completed NCT01674881 Not Applicable
27 Electrophysiological Correlates of Emotional and Crossmodal Stimuli Processing Among Alcohol-dependent Participants Completed NCT01633905
28 Plasticity of the Compassionate Brain Completed NCT01833104 Not Applicable
29 Stress Management for Irritable Bowel Syndrome Completed NCT01886027 Not Applicable
30 Mindfulness for Irritable Bowel Syndrome Completed NCT02794376 Not Applicable
31 Improving Happiness in Flanders Completed NCT02041741 Not Applicable
32 Chronic Low Back Pain: A Multidisciplinary Approach Completed NCT01993355 Not Applicable
33 Training to Reconnect With Emotional Awareness Therapy Recruiting NCT03414463 Not Applicable
34 Positive Emotion Regulation Training in Children, Adolescents and Young Adults With and Without Developmental Disorder Recruiting NCT02898298 Not Applicable
35 Re-nutrition in Severe Anorexia Nervosa Recruiting NCT02502617
36 CBT-Eb Plus EMDR Versus CBT-Eb in Patients With Eating Disorders Recruiting NCT03156959 Not Applicable
37 Stress Management in Obesity During a Thermal Spa Residential Program Recruiting NCT03578757 Not Applicable
38 Influence of Main Psychological and Social Factors on Primary Headaches Recruiting NCT03577548
39 Student Outcomes of Integrative Mental Health Services Recruiting NCT02877875 Not Applicable
40 Oculomotor Markers and Attachment in Adolescents Recruiting NCT02851810 Not Applicable
41 Randomized Controlled Study of the Efficacy of Hypnosis Versus Relaxation and Control in Neuropathic Pain Recruiting NCT02256371 Not Applicable
42 Improving Emotion Regulation Skills Among Adolescents Attempting to Lose Weight Recruiting NCT03393221 Not Applicable
43 Effectiveness of Buprenorphine/Naloxone Recruiting NCT02882412
44 A SYNdemic BASed INtervention for MSM With High Risk Behavior: Design of a Randomized Controlled Trial Active, not recruiting NCT02859935 Not Applicable
45 Mental Training for CFS Following EBV Infection in Adolescents Active, not recruiting NCT02499302 Not Applicable
46 Psychological Variables and Hyperglycemia in Diabetes Mellitus Enrolling by invitation NCT01714986 Not Applicable
47 Development of Reward Processing in Prenatally Exposed Adolescents and Young Adults Enrolling by invitation NCT03268759
48 Evaluation of Art-therapy on Alexithymia in Patients Suffering From Anorexia Nervosa and From Bulimia Not yet recruiting NCT03524443
49 Asthma, Smoking, Emotional Deficits Not yet recruiting NCT03312673
50 Automated Assessment Using Facial Coding Not yet recruiting NCT03551886 Not Applicable

Search NIH Clinical Center for Alexithymia

Genetic Tests for Alexithymia

Anatomical Context for Alexithymia

MalaCards organs/tissues related to Alexithymia:

41
Brain, Breast, Testes, Heart, Cortex, Skin, Eye

Publications for Alexithymia

Articles related to Alexithymia:

(show top 50) (show all 715)
# Title Authors Year
1
Attachment avoidance, alexithymia, and gender: Examining their associations with distress disclosure tendencies and event-specific disclosure. ( 29355345 )
2018
2
Is alexithymia characterised by impaired interoception? Further evidence, the importance of control variables, and the problems with the Heartbeat Counting Task. ( 29803614 )
2018
3
Body talk: Sex differences in the influence of alexithymia on physical complaints among psychiatric outpatients. ( 29309955 )
2018
4
Affect labeling and other aspects of emotional experiences in relation to alexithymia following standardized emotion inductions. ( 29428774 )
2018
5
Childhood Trauma and Functional Variants of 5-HTTLPR Are Independently Associated with Alexithymia in 5,283 Subjects from the General Population. ( 29306941 )
2018
6
Psychoeducation against depression, anxiety, alexithymia and fibromyalgia: a pilot study in primary care for patients on sick leave. ( 29693478 )
2018
7
The functional and structural characteristics of the emotion network in alexithymia. ( 29695908 )
2018
8
Alexithymia and autistic traits as possible predictors for traits related to depression, anxiety, and stress: A multivariate statistical approach. ( 29882629 )
2018
9
Subjective and Objective: Alexithymia and Social Cognition in Eating Disorders. ( 29916406 )
2018
10
Psychometric Properties of the Bermond-Vorst Alexithymia Questionnaire (BVAQ) in the General Population and a Clinical Population. ( 29740350 )
2018
11
Association of Internet addiction and alexithymia - A scoping review. ( 29429757 )
2018
12
Alexithymia as a potential source of symptom over-reporting: An exploratory study in forensic patients and non-forensic participants. ( 29349809 )
2018
13
Are alexithymia and empathy predicting factors of the resilience of medical residents in France? ( 29731450 )
2018
14
Headache and Alexithymia in Children and Adolescents: What Is the Connection? ( 29449820 )
2018
15
Association Between Alexithymia and Functional Gastrointestinal Disorders. ( 29922191 )
2018
16
Do terrorists suffer from alexithymia? ( 29417660 )
2018
17
The influence of alexithymia on mobile phone addiction: The role of depression, anxiety and stress. ( 28926906 )
2018
18
Language and alexithymia: Evidence for the role of the inferior frontal gyrus in acquired alexithymia. ( 29360519 )
2018
19
Alexithymia and Somatosensory Amplification Link Perceived Psychosocial Stress and Somatic Symptoms in Outpatients with Psychosomatic Illness. ( 29748483 )
2018
20
Symptom, alexithymia and self-image outcomes of Mentalisation-based treatment for borderline personality disorder: a naturalistic study. ( 29890960 )
2018
21
Assessing advanced theory of mind and alexithymia in patients suffering from enduring borderline personality disorder. ( 29360051 )
2018
22
The Relationship Between Alexithymia and Emotional Awareness: A Meta-Analytic Review of the Correlation Between TAS-20 and LEAS. ( 29713295 )
2018
23
Bullying and alexithymia: Are there differences between traditional, cyber, combined bullies, and nonbullies in reading their own emotions? ( 29952143 )
2018
24
The Impact of Alexithymia on Emotion Dysregulation in Anorexia Nervosa and Bulimia Nervosa over Time. ( 29266572 )
2018
25
The relationship between alexithymia and headache impact: the role of somatization and pain catastrophizing. ( 29869297 )
2018
26
Influence of anxiety and alexithymia on brain activations associated with the perception of others' pain in autism. ( 29683406 )
2018
27
Psychometric Properties of the 20-Item Toronto Alexithymia Scale in the Chilean Population. ( 29946289 )
2018
28
A scoping review of suicidality and alexithymia: The need to consider interoception. ( 29913380 )
2018
29
Traumatic Experiences, Stressful Events, and Alexithymia in Chronic Migraine With Medication Overuse. ( 29867669 )
2018
30
Looking at the eyes interferes with facial emotion recognition in alexithymia. ( 29792440 )
2018
31
Alexithymia in Young Adults With Substance Use Disorders: Critical Issues About Specificity and Treatment Predictivity. ( 29872408 )
2018
32
Alexithymia Is Related to the Need for More Emotional Intensity to Identify Static Fearful Facial Expressions. ( 29942271 )
2018
33
Parental Alexithymia, Depression and Anxiety Levels of Children with Neurodevelopmental Disorders: A Comparative Study with Pervasive Developmental Disorders and ADHD. ( 29290095 )
2017
34
Relationship between pathological gambling, alexithymia, and gambling type. ( 28211964 )
2017
35
Moderating Effects of Alexithymia on Associations between the Therapeutic Alliance and the Outcome of Brief Psychodynamic-Interpersonal Psychotherapy for Multisomatoform Disorder. ( 29255429 )
2017
36
Alexithymia as a Moderator of Treatment Outcomes in a Randomized Controlled Trial on Brief Psychodynamic Interpersonal Psychotherapy for Patients with Multisomatoform Disorder. ( 27884003 )
2017
37
Reductions in Alexithymia and Emotion Dysregulation After Training Emotional Self-Awareness Following Traumatic Brain Injury: A Phase I Trial. ( 28060205 )
2017
38
Prevalence and associated factors of alexithymia among adult prisoners in China: a cross-sectional study. ( 28768497 )
2017
39
Childhood maltreatment is associated with attachment insecurities, dissociation and alexithymia in bipolar disorder. ( 29253803 )
2017
40
Psychopathology and alexithymia in patients with psoriasis. ( 28954100 )
2017
41
Alexithymia as a mediator of the relationship between child sexual abuse and psychological distress in adolescence: A short-term longitudinal study. ( 29274605 )
2017
42
Rash Impulsiveness and Negative Mood, but not Alexithymia or Reward Sensitivity, Differentiate Young to Middle-Aged Chronic Daily Smokers from Never-Smokers. ( 28895792 )
2017
43
A Study of the Characteristics of Alexithymia and Emotion Regulation in Patients with Depression. ( 28765680 )
2017
44
Cognitive factors and post-partum depression: What is the influence of general personality traits, rumination, maternal self-esteem, and alexithymia? ( 29282785 )
2017
45
"Lacking warmth": Alexithymia trait is related to warm-specific thermal somatosensory processing. ( 28735971 )
2017
46
Alexithymia and Suicide Risk in Psychiatric Disorders: A Mini-Review. ( 28855878 )
2017
47
On the Processes Underlying the Relationship Between Alexithymia and Gambling Severity. ( 28866795 )
2017
48
Alexithymia as a Transdiagnostic Precursor to Empathy Abnormalities: The Functional Role of the Insula. ( 29312079 )
2017
49
The mediating effects of cognitive emotion regulation strategies on the relationship between alexithymia and physical symptoms: Evidence from Iranian asthmatic patients. ( 27898375 )
2017
50
Depression differed by midnight cortisol secretion, alexithymia and anxiety between diabetes types: a cross sectional comparison. ( 28931368 )
2017

Variations for Alexithymia

Expression for Alexithymia

Search GEO for disease gene expression data for Alexithymia.

Pathways for Alexithymia

GO Terms for Alexithymia

Biological processes related to Alexithymia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to cocaine GO:0042220 9.43 DRD2 OXTR
2 acute-phase response GO:0006953 9.4 CRP IL6
3 response to amphetamine GO:0001975 9.37 DRD2 OXTR
4 vasoconstriction GO:0042310 9.32 HTR1A SLC6A4
5 dopamine metabolic process GO:0042417 9.26 COMT DRD2
6 response to drug GO:0042493 9.26 COMT DRD2 OXTR SLC6A4
7 negative regulation of lipid storage GO:0010888 9.16 CRP IL6
8 sperm ejaculation GO:0042713 8.62 OXTR SLC6A4

Molecular functions related to Alexithymia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 obsolete signal transducer activity GO:0004871 8.92 DRD2 HTR1A OXTR TAS2R38

Sources for Alexithymia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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