MCID: ALG001
MIFTS: 40

Algoneurodystrophy

Categories: Neuronal diseases

Aliases & Classifications for Algoneurodystrophy

MalaCards integrated aliases for Algoneurodystrophy:

Name: Algoneurodystrophy 12 15 73
Reflex Sympathetic Dystrophy 73

Classifications:



External Ids:

Disease Ontology 12 DOID:14022
ICD10 33 M89.0 M89.00
ICD9CM 35 733.7
SNOMED-CT 68 7359008

Summaries for Algoneurodystrophy

MalaCards based summary : Algoneurodystrophy, also known as reflex sympathetic dystrophy, is related to reflex sympathetic dystrophy and herpes zoster. An important gene associated with Algoneurodystrophy is LCAT (Lecithin-Cholesterol Acyltransferase), and among its related pathways/superpathways are NRF2 pathway and Busulfan Pathway, Pharmacodynamics. The drugs Amitriptyline and Perphenazine have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and spinal cord, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Complex Regional Pain Syndrome (CRPS), also known as Reflex Sympathetic Dystrophy (RSD), is a disorder... more...

Related Diseases for Algoneurodystrophy

Graphical network of the top 20 diseases related to Algoneurodystrophy:



Diseases related to Algoneurodystrophy

Symptoms & Phenotypes for Algoneurodystrophy

GenomeRNAi Phenotypes related to Algoneurodystrophy according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.32 GGT2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.32 GGT1 GGT2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-131 9.32 GGT2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-143 9.32 GGT1 GGT2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.32 GGT1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-24 9.32 GGT2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.32 GGT1 GGT2

Drugs & Therapeutics for Algoneurodystrophy

Drugs for Algoneurodystrophy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amitriptyline Approved Phase 2 50-48-6 2160
2
Perphenazine Approved Phase 2 58-39-9 4748
3 Analgesics Phase 2,Not Applicable
4 Anesthetics, Local Phase 2
5 Anti-Inflammatory Agents Phase 2
6 Anti-Inflammatory Agents, Non-Steroidal Phase 2
7 Amitriptyline, perphenazine drug combination Phase 2
8 Psychotropic Drugs Phase 2
9 Antipsychotic Agents Phase 2
10 Antidepressive Agents, Tricyclic Phase 2
11 Anesthetics Phase 2
12 Peripheral Nervous System Agents Phase 2,Not Applicable
13 Analgesics, Non-Narcotic Phase 2
14 Central Nervous System Depressants Phase 2
15 Antidepressive Agents Phase 2
16 Neurotransmitter Uptake Inhibitors Phase 2
17 Cyclooxygenase Inhibitors Phase 2
18 Antirheumatic Agents Phase 2
19 Adrenergic Agents Phase 2
20 Neurotransmitter Agents Phase 2
21 Tranquilizing Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Amitriptyline Regarding Nimesulide in Acute Idiopathic Adhesive Capsulitis Completed NCT01306708 Phase 2 amitriptyline
2 Comparison of the Analgesic Effect Between the Motor Cortex Stimulation and the Trans-spinal Stimulation in the Algoneurodystrophy. Recruiting NCT02817880 Not Applicable

Search NIH Clinical Center for Algoneurodystrophy

Genetic Tests for Algoneurodystrophy

Anatomical Context for Algoneurodystrophy

MalaCards organs/tissues related to Algoneurodystrophy:

41
Bone, Skin, Spinal Cord, Testes, Cortex, Pituitary, Pancreas

Publications for Algoneurodystrophy

Articles related to Algoneurodystrophy:

(show top 50) (show all 827)
# Title Authors Year
1
How a Simple Ankle Sprain Turned Into Neuropathic Pain: Complex Reflex Sympathetic Dystrophy Versus Erythromelalgia. ( 29121832 )
2017
2
Pain, Complex Regional Pain Syndrome (Reflex Sympathetic Dystrophy, RSD, CRPS) ( 28613470 )
2017
3
Bone SPECT/CT Localizes Increased Bone Metabolism and Subsequent Bone Resorption in Reflex Sympathetic Dystrophy. ( 28806248 )
2017
4
The Relation Between Reflex Sympathetic Dystrophy Syndrome and Trauma Severity in Patients With Distal Tibia Fracture. ( 27626009 )
2016
5
Re: del Pinal F. Editorial: I have a dream ... reflex sympathetic dystrophy (RSD or Complex Regional Pain Syndrome - CRPS I) does not exist. J Hand Surg Eur. 2013, 38: 595-7. ( 24566455 )
2014
6
Re: del Pinal F. Editorial: I have a dream ... reflex sympathetic dystrophy (RSD or Complex Regional Pain Syndrome - CRPS I) does not exist. J Hand Surg Eur. 2013, 38: 595-7. ( 24448795 )
2014
7
Reflex sympathetic dystrophy-like syndrome, possibly caused by aripiprazole, in an adolescent patient. ( 25020186 )
2014
8
Sympathomimetic amine therapy found effective for treatment of refractory chronic complex regional pain syndrome (reflex sympathetic dystrophy). ( 25134306 )
2014
9
Reply: F del Piñal. Editorial: I have a dream … reflex sympathetic dystrophy (RSD or complex regional pain syndrome - CRPS I) does not exist. J Hand Surg Eur. 38: 595-7. ( 24596947 )
2014
10
Re: del PiA+al F. Editorial: I have a dream ... reflex sympathetic dystrophy (RSD or Complex Regional Pain Syndrome--CRPS 1) does not exist. J Hand Surg Eur. 2013, 38: 595-7. ( 24158709 )
2013
11
Editorial. I have a dream ... reflex sympathetic dystrophy (RSD or Complex Regional Pain Syndrome - CRPS I) does not exist. ( 23778064 )
2013
12
A case of linear morphoea mistaken for reflex sympathetic dystrophy. ( 23546034 )
2013
13
Unilateral Beau's lines in a case of complex regional pain syndrome (reflex sympathetic dystrophy). ( 23075662 )
2012
14
Reflex sympathetic dystrophy syndrome in a child. ( 21993705 )
2011
15
My sister fell and injured her shoulder a few months ago. She's developed terrible burning pain down into her arm. Her doctor says she has complex regional pain syndrome, also known as reflex sympathetic dystrophy. What is it? How is it treated? ( 21344692 )
2011
16
Reflex sympathetic dystrophy following pacemaker insertion. ( 22334977 )
2011
17
Tenosynovitis caused by a pseudallescheria boydii infection and symptoms of reflex sympathetic dystrophy after a dog bite. ( 21946460 )
2011
18
Lawsuit verdicts and settlements involving reflex sympathetic dystrophy and complex regional pain syndrome. ( 22214139 )
2011
19
Induction of prolonged mania during ketamine therapy for reflex sympathetic dystrophy. ( 21529780 )
2011
20
Is this complex regional pain syndrome or reflex sympathetic dystrophy? ( 21632229 )
2011
21
Reply: Is reflex sympathetic dystrophy/complex regional pain syndrome type I a small-fiber neuropathy? ( 20583223 )
2010
22
Complex regional pain syndrome/reflex sympathetic dystrophy. ( 20504141 )
2010
23
A hypothesis for the cause of complex regional pain syndrome-type I (reflex sympathetic dystrophy): pain due to deep-tissue microvascular pathology. ( 20704671 )
2010
24
A severe case of complex regional pain syndrome I (reflex sympathetic dystrophy) managed with spinal cord stimulation. ( 19863748 )
2010
25
Reflex sympathetic dystrophy in patients with metastatic renal cell carcinoma treated with everolimus. ( 19649567 )
2010
26
Is reflex sympathetic dystrophy/complex regional pain syndrome type I a small-fiber neuropathy? ( 19557864 )
2009
27
The efficacy of manual lymphatic drainage therapy in the management of limb edema secondary to reflex sympathetic dystrophy. ( 19030864 )
2009
28
Reflex sympathetic dystrophy secondary to deep venous thrombosis mimicking post-thrombotic syndrome. ( 19363611 )
2009
29
Reflex sympathetic dystrophy: complex regional pain syndrome type I in children with mitochondrial disease and maternal inheritance. ( 18192313 )
2008
30
Factitious lymphoedema as a psychiatric condition mimicking reflex sympathetic dystrophy: a case report. ( 18577230 )
2008
31
Reflex sympathetic dystrophy/complex regional pain syndrome. ( 18306652 )
2008
32
Unilateral trachyonychia in a patient with reflex sympathetic dystrophy. ( 18222330 )
2008
33
Complex regional pain syndrome (reflex sympathetic dystrophy) in a patient with essential mixed cryoglobulinemia and chronic hepatitis C. ( 17370795 )
2007
34
The effect of gabapentin in earlier stage of reflex sympathetic dystrophy. ( 16897121 )
2007
35
Unusual cases of acquired leukonychia totalis and partialis secondary to reflex sympathetic dystrophy. ( 17958875 )
2007
36
Complex regional pain syndrome I (reflex sympathetic dystrophy) associated with a superficial hand burn from a fan heater. ( 17535413 )
2007
37
Reflex sympathetic dystrophy: a case of total body pain. ( 17721352 )
2007
38
Reflex sympathetic dystrophy: a retrospective epidemiological study of 168 patients. ( 17221145 )
2007
39
Effects of weather changes on a patient with reflex sympathetic dystrophy. ( 17387368 )
2007
40
Reflex sympathetic dystrophy: reflections from a clinician. ( 18605399 )
2007
41
Reflex sympathetic dystrophy in a renal transplant patient treated with sirolimus. ( 17575313 )
2007
42
The role of the pain psychologist, trigger point injections, reflex sympathetic dystrophy. ( 17182517 )
2006
43
Spinal cord stimulation for chronic reflex sympathetic dystrophy--five-year follow-up. ( 16738284 )
2006
44
Current management of reflex sympathetic dystrophy syndrome (complex regional pain syndrome type I). ( 16837228 )
2006
45
Impact of three-phase bone scintigraphy on the diagnosis and treatment of complex regional pain syndrome type I or reflex sympathetic dystrophy. ( 16340227 )
2006
46
Evidence of focal small-fiber axonal degeneration in complex regional pain syndrome-I (reflex sympathetic dystrophy). ( 16427737 )
2006
47
Determination of inflammation of reflex sympathetic dystrophy at early stages with Tc-99m HIG scintigraphy: preliminary results. ( 16025330 )
2006
48
Psychiatric approach in the treatment of reflex sympathetic dystrophy in an adolescent girl: a case report. ( 17290576 )
2006
49
Reflex sympathetic dystrophy in hemiplegia. ( 17106342 )
2006
50
Sympathetic skin responses in reflex sympathetic dystrophy. ( 16328419 )
2006

Variations for Algoneurodystrophy

Expression for Algoneurodystrophy

Search GEO for disease gene expression data for Algoneurodystrophy.

Pathways for Algoneurodystrophy

Pathways related to Algoneurodystrophy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.42 GGT1 GGT2
2
Show member pathways
10.8 GGT1 GGT2
3 10.34 GGT1 GGT2
4 9.98 GGT1 GGT2

GO Terms for Algoneurodystrophy

Cellular components related to Algoneurodystrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 8.92 CALCA GGT1 LCAT NGF

Biological processes related to Algoneurodystrophy according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 response to estradiol GO:0032355 9.51 GGT1 GGT2
2 regulation of inflammatory response GO:0050727 9.49 GGT1 GGT2
3 cellular amino acid metabolic process GO:0006520 9.48 GGT1 GGT2
4 glutathione metabolic process GO:0006749 9.46 GGT1 GGT2
5 response to tumor necrosis factor GO:0034612 9.43 GGT1 GGT2
6 glutamate metabolic process GO:0006536 9.4 GGT1 GGT2
7 zymogen activation GO:0031638 9.37 GGT1 GGT2
8 glutathione catabolic process GO:0006751 9.32 GGT1 GGT2
9 leukotriene D4 biosynthetic process GO:1901750 9.26 GGT1 GGT2
10 cysteine biosynthetic process GO:0019344 9.16 GGT1 GGT2
11 regulation of immune system process GO:0002682 8.96 GGT1 GGT2
12 peptide modification GO:0031179 8.62 GGT1 GGT2

Molecular functions related to Algoneurodystrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutathione hydrolase activity GO:0036374 8.96 GGT1 GGT2
2 peptidyltransferase activity GO:0000048 8.62 GGT1 GGT2

Sources for Algoneurodystrophy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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