MCID: ALG001
MIFTS: 40

Algoneurodystrophy

Categories: Neuronal diseases

Aliases & Classifications for Algoneurodystrophy

MalaCards integrated aliases for Algoneurodystrophy:

Name: Algoneurodystrophy 12 15 74
Reflex Sympathetic Dystrophy 74

Classifications:



External Ids:

Disease Ontology 12 DOID:14022
ICD9CM 36 733.7
SNOMED-CT 69 7359008
ICD10 34 M89.0 M89.00

Summaries for Algoneurodystrophy

MalaCards based summary : Algoneurodystrophy, also known as reflex sympathetic dystrophy, is related to reflex sympathetic dystrophy and prolactin producing pituitary tumor. An important gene associated with Algoneurodystrophy is LCAT (Lecithin-Cholesterol Acyltransferase), and among its related pathways/superpathways are Busulfan Pathway, Pharmacodynamics and Eicosanoid Synthesis. The drugs Bupivacaine and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and skin.

Wikipedia : 77 Complex regional pain syndrome (CRPS), also known as reflex sympathetic dystrophy (RSD), is a disorder... more...

Related Diseases for Algoneurodystrophy

Graphical network of the top 20 diseases related to Algoneurodystrophy:



Diseases related to Algoneurodystrophy

Symptoms & Phenotypes for Algoneurodystrophy

Drugs & Therapeutics for Algoneurodystrophy

Drugs for Algoneurodystrophy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 159)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 4,Phase 3,Not Applicable 38396-39-3, 2180-92-9 2474
2
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Not Applicable 124-94-7 31307
3
Lidocaine Approved, Vet_approved Phase 4,Not Applicable,Early Phase 1 137-58-6 3676
4
Gabapentin Approved, Investigational Phase 4,Not Applicable 60142-96-3 3446
5
Salmon Calcitonin Approved, Investigational Phase 4 47931-85-1 16129616
6
Vitamin C Approved, Nutraceutical Phase 4,Phase 3,Not Applicable 50-81-7 54670067 5785
7
Calcium Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable 7440-70-2 271
8
Calcitonin gene-related peptide Investigational Phase 4 83652-28-2
9 Triamcinolone diacetate Phase 4,Phase 3,Not Applicable
10 Triamcinolone hexacetonide Phase 4,Phase 3,Not Applicable
11 triamcinolone acetonide Phase 4,Phase 3,Not Applicable
12 Vitamins Phase 4,Phase 3,Not Applicable
13 Trace Elements Phase 4,Phase 3,Not Applicable
14 Protective Agents Phase 4,Phase 3,Not Applicable
15 Antioxidants Phase 4,Phase 3,Not Applicable
16 Micronutrients Phase 4,Phase 3,Not Applicable
17 Nutrients Phase 4,Phase 3,Not Applicable
18 Neurotransmitter Agents Phase 4,Phase 2,Not Applicable,Early Phase 1
19 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
20 Anesthetics Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
21 Anesthetics, Local Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
22 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
23 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
24 Psychotropic Drugs Phase 4,Phase 2,Not Applicable
25 Hormones Phase 4,Phase 3,Phase 2,Not Applicable
26 Bone Density Conservation Agents Phase 4,Phase 2,Phase 3
27 Excitatory Amino Acids Phase 4,Phase 2,Not Applicable
28 Excitatory Amino Acid Antagonists Phase 4,Phase 2,Not Applicable
29 Anticonvulsants Phase 4,Phase 2,Not Applicable
30 Diuretics, Potassium Sparing Phase 4,Not Applicable,Early Phase 1
31 Sodium Channel Blockers Phase 4,Not Applicable,Early Phase 1
32 Tranquilizing Agents Phase 4,Phase 2,Not Applicable
33 Antimanic Agents Phase 4,Not Applicable
34 Anti-Arrhythmia Agents Phase 4,Phase 2,Not Applicable,Early Phase 1
35 Anti-Anxiety Agents Phase 4,Phase 2,Not Applicable
36 Vasodilator Agents Phase 4,Phase 2
37 Calcium, Dietary Phase 4,Phase 3,Phase 2,Not Applicable
38 Katacalcin Phase 4
39 calcitonin Phase 4
40
Ropivacaine Approved Phase 3,Not Applicable 84057-95-4 175805 71273
41
Levobupivacaine Approved, Investigational Phase 3,Not Applicable 27262-47-1 92253
42
Zoledronic Acid Approved Phase 3,Phase 2 118072-93-8 68740
43
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3,Not Applicable 437-38-7 3345
44
Guaifenesin Approved, Investigational, Vet_approved Phase 3 93-14-1 3516
45
Hydrocodone Approved, Illicit, Investigational Phase 3 125-29-1 5284569
46
Sodium Citrate Approved, Investigational Phase 3 68-04-2
47
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
48
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
49
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
50
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741

Interventional clinical trials:

(show top 50) (show all 150)
# Name Status NCT ID Phase Drugs
1 Tolerability of Suprascapular and Median Nerve Blocks for the Treatment of Shoulder-hand Syndrome Completed NCT03291197 Phase 4 Suprascapular and median nerve blocks
2 Prophylactic Administration of Vitamin C in Wrist Fractures Completed NCT00296868 Phase 4 ascorbic acid (vitamin C) versus placebo
3 Restore Claims Characterization Study Completed NCT00200122 Phase 4
4 A Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions Completed NCT00904202 Phase 4 Placebo Capsules + Placebo Patch;Placebo capsules + Lidoderm®;Gabapentin + Placebo;Gabapentin + Lidoderm®;Gabapentin 300 mg capsules 1800 mg/day + placebo patch;Gabapentin 1800 mg/day + Lidoderm patch
5 High Frequency Stimulation Trials in Patients With Precision Spinal Cord Stimulator System Completed NCT02265848 Phase 4
6 Bupivacaine Versus Lidocaine Local Anesthesia Completed NCT01751347 Phase 4 Bupivacaine;Lidocaine
7 Efficacy and Safety of Salmon Calcitonin Nasal Spray in Improving Muscle Strength and Reducing Pain After Forearm Fracture in Postmenopausal Women Completed NCT00239889 Phase 4 Salmon calcitonin
8 Fasciectomy vs Collagenase Injection in Recurrent Dupuytren Disease Enrolling by invitation NCT03406338 Phase 4 Collagenase Clostridium Histolyticum
9 (SGB) in Men Treated for Prostate Cancer Improve Hot Flashes Not yet recruiting NCT03796195 Phase 4 .5% Bupivacaine
10 Acupuncture for Post-stroke Shoulder-hand Syndrome Unknown status NCT02011854 Phase 2, Phase 3
11 Role of Vitamin C at 6 Months on Incidence of Complex Regional Pain Syndrome Type I in Upper Limb Surgery Unknown status NCT02390505 Phase 3 Vitamin C;Placebo
12 RCT :Thoracic Sympathetic Block for the Treatment of Complex Regional Pain Syndrome I of the Upper Limb Unknown status NCT01612364 Phase 3
13 Intravenous Immunoglobulins in Complex-regional Pain Syndrome Unknown status NCT00949065 Phase 3
14 Surgical Treatment Of Complex Regional Pain Syndrome Type II (CRPS II) Unknown status NCT01392599 Phase 3
15 Analysis of Photoplethysmographic Signal in Lumbar Sympathetic Block Unknown status NCT01134289 Phase 3
16 Efficacy and Safety of Intravenous Neridronic Acid in CRPS-I Completed NCT02402530 Phase 2, Phase 3 Placebo;Neridronic acid 62.5 mg
17 Pain Exposure Physical Therapy (PEPT) Versus CBO in Patients With Complex Regional Pain Syndrome Type I (CRPS-1) Completed NCT00817128 Phase 2, Phase 3
18 A Study of the Effect of Lenalidamide on Complex Regional Pain Syndrome Type 1 Completed NCT00166452 Phase 3 Lenalidamide
19 Safety of Intravenous Neridronic Acid in CRPS Completed NCT02972359 Phase 3 Neridronic acid
20 A Confirmatory Study of Fentanyl in Participants With Post-herpetic Neuralgia, Complex Regional Pain Syndrome or Postoperative Pain Syndrome Completed NCT01008553 Phase 3 Fentanyl;Placebo
21 STRIPS: Shoulder Taping Reduces Injury and Pain in Stroke Completed NCT01062308 Phase 3
22 Study to Evaluate the Long-Term Safety of Hydrocodone Bitartrate Extended-Release Tablets (CEP-33237) in Patients Who Require Opioid Treatment for an Extended Period of Time Completed NCT01223365 Phase 3 Hydrocodone ER
23 Study to Evaluate the Efficacy and Safety of OraVescent Fentanyl Citrate Treatment for the Management of Breakthrough Pain in Opioid-Tolerant Patients With Noncancer-Related Chronic Pain Completed NCT00343733 Phase 3 OraVescent Fentanyl
24 Efficacy and Safety of Intravenous Neridronic Acid in Complex Regional Pain Syndrome (CRPS) Recruiting NCT03560986 Phase 3 Neridronic acid;Placebo
25 Efficacy and Safety of Intravenous Neridronic Acid in CRPS Recruiting NCT03530345 Phase 3 Neridronic acid;Placebo
26 CREATE-1: A Study to Assess the Efficacy and Safety of AXS-02 in Patients With CRPS-1 Active, not recruiting NCT02504008 Phase 3 AXS-02 (oral zoledronate);Placebo
27 Soft Part Management for Surgical Fractures of the Lower Limb Not yet recruiting NCT03915223 Phase 3 Solumedrol (steroidal anti-inflammatory drug)
28 Transcranial Magnetic Stimulation (TMS) Effects on Pain Perception Withdrawn NCT00349050 Phase 2, Phase 3
29 The Use of Zoledronic Acid to Complex Regional Pain Syndrome Unknown status NCT01788176 Phase 2 Zoledronic acid;Placebo
30 Effect of Delta-9-Tetrahydrocannabinol on the Prevention of Chronic Pain in Patients With Acute CRPS (ETIC-Study) Unknown status NCT00377468 Phase 2 Delta9-Tetrahydrocannabinol
31 Dupuytren's Disease and Extracorporeal Shockwave Therapy (DupuyShock-2010) Unknown status NCT01184586 Phase 2
32 Amitriptyline Regarding Nimesulide in Acute Idiopathic Adhesive Capsulitis Completed NCT01306708 Phase 2 amitriptyline
33 A Study of CC-5013 in the Treatment of Complex Regional Pain Syndrome (CRPS) Completed NCT00067743 Phase 2 Lenalidomide
34 Prospective, Randomized Controlled Trial on Perioperative Pregabalin to Reduce Late-onset CRPS After TKA Completed NCT00558753 Phase 2 pregabalin;Placebo
35 Double Blind Placebo Controlled Study of Outpatient Intravenous Ketamine for the Treatment of CRPS Completed NCT00579085 Phase 2 Ketamine
36 Novel Treatment Option for Neuropathic Pain Completed NCT02490436 Phase 2 Cetuximab;Placebo
37 Study of HC-58 in Upper Limb Hemiplegic Patients After Stroke Completed NCT01623622 Phase 2 HC-58;Placebo
38 A Pilot Trial of IV Pamidronate for Low Back Pain Completed NCT01210599 Phase 1, Phase 2 Pamidronate
39 Effects of Vaporized Marijuana on Neuropathic Pain Completed NCT01037088 Phase 1, Phase 2 Mild dose cannabis;Low dose cannabis;Cannabis
40 Clonidine Versus Adenosine to Treat Neuropathic Pain Completed NCT00349921 Phase 2 clonidine;adenosine;placebo;placebo
41 Adipose Stem/Stromal Cells in RSD, CRPS, Fibromyalgia Enrolling by invitation NCT02987855 Phase 1, Phase 2
42 Study to Evaluate the Efficacy and Safety of Lenalidomide in the Treatment of Complex Regional Pain Syndrome Type 1 Terminated NCT00109772 Phase 2 lenalidomide;Placebo
43 Randomized Controlled Trial of Ketamine Infusion With Continuous Epidural Infusion for Treatment of Complex Regional Pain Syndrome Terminated NCT02094352 Phase 2 Ketamine Infusion + Epidural Infusion;Control Group + Epidural infusion;Ketamine Booster Infusion;Control Group Booster Infusion
44 Safety and Efficacy Study of Ethosuximide for the Treatment of Complex Regional Pain Syndrome (CRPS) Terminated NCT00689585 Phase 2 Placebo;Ethosuximide
45 Neurotropin to Treat Chronic Neuropathic Pain Terminated NCT00006289 Phase 2 Placebo;Neurotropin
46 Efficacy of Etoricoxib on Peripheral Hyperalgesia Terminated NCT01088256 Phase 2 Etoricoxib;placebo
47 Single-portal Endoscopic Carpal Tunnel Release Versus Knifelight for Carpal Tunnel Syndrome. A Randomized Control Trial Withdrawn NCT01756820 Phase 2
48 Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain. Terminated NCT02321566 Phase 1
49 Two Measures of Tactile Acuity in CRPS Type I Patients Unknown status NCT01888783 Not Applicable
50 Effects of Repetitive Electric Sensory Stimulation (RSS) as Intervention in Complex-regional-pain-syndrome Type I (CRPS) Unknown status NCT01915329 Not Applicable

Search NIH Clinical Center for Algoneurodystrophy

Genetic Tests for Algoneurodystrophy

Anatomical Context for Algoneurodystrophy

MalaCards organs/tissues related to Algoneurodystrophy:

42
Bone, Spinal Cord, Skin, Cortex, Dorsal Root Ganglion, Heart, Prostate

Publications for Algoneurodystrophy

Articles related to Algoneurodystrophy:

(show top 50) (show all 827)
# Title Authors Year
1
Electroacupuncture for Reflex Sympathetic Dystrophy after Stroke: A Meta-Analysis. ( 30826129 )
2019
2
How a Simple Ankle Sprain Turned Into Neuropathic Pain: Complex Reflex Sympathetic Dystrophy Versus Erythromelalgia. ( 29121832 )
2018
3
Bone SPECT/CT Localizes Increased Bone Metabolism and Subsequent Bone Resorption in Reflex Sympathetic Dystrophy. ( 28806248 )
2017
4
The Relation Between Reflex Sympathetic Dystrophy Syndrome and Trauma Severity in Patients With Distal Tibia Fracture. ( 27626009 )
2016
5
Sympathomimetic amine therapy found effective for treatment of refractory chronic complex regional pain syndrome (reflex sympathetic dystrophy). ( 25134306 )
2014
6
Re: del Pinal F. Editorial: I have a dream ... reflex sympathetic dystrophy (RSD or Complex Regional Pain Syndrome - CRPS I) does not exist. J Hand Surg Eur. 2013, 38: 595-7. ( 24448795 )
2014
7
Re: del Pinal F. Editorial: I have a dream ... reflex sympathetic dystrophy (RSD or Complex Regional Pain Syndrome - CRPS I) does not exist. J Hand Surg Eur. 2013, 38: 595-7. ( 24566455 )
2014
8
Reply: F del Piñal. Editorial: I have a dream … reflex sympathetic dystrophy (RSD or complex regional pain syndrome - CRPS I) does not exist. J Hand Surg Eur. 38: 595-7. ( 24596947 )
2014
9
Reflex sympathetic dystrophy-like syndrome, possibly caused by aripiprazole, in an adolescent patient. ( 25020186 )
2014
10
Re: del Piñal F. Editorial: I have a dream ... reflex sympathetic dystrophy (RSD or Complex Regional Pain Syndrome--CRPS 1) does not exist. J Hand Surg Eur. 2013, 38: 595-7. ( 24158709 )
2013
11
Editorial. I have a dream ... reflex sympathetic dystrophy (RSD or Complex Regional Pain Syndrome - CRPS I) does not exist. ( 23778064 )
2013
12
A case of linear morphoea mistaken for reflex sympathetic dystrophy. ( 23546034 )
2013
13
Unilateral Beau's lines in a case of complex regional pain syndrome (reflex sympathetic dystrophy). ( 23075662 )
2012
14
Is this complex regional pain syndrome or reflex sympathetic dystrophy? ( 21632229 )
2011
15
Lawsuit verdicts and settlements involving reflex sympathetic dystrophy and complex regional pain syndrome. ( 22214139 )
2011
16
Induction of prolonged mania during ketamine therapy for reflex sympathetic dystrophy. ( 21529780 )
2011
17
Tenosynovitis caused by a pseudallescheria boydii infection and symptoms of reflex sympathetic dystrophy after a dog bite. ( 21946460 )
2011
18
Reflex sympathetic dystrophy syndrome in a child. ( 21993705 )
2011
19
Reflex sympathetic dystrophy following pacemaker insertion. ( 22334977 )
2011
20
My sister fell and injured her shoulder a few months ago. She's developed terrible burning pain down into her arm. Her doctor says she has complex regional pain syndrome, also known as reflex sympathetic dystrophy. What is it? How is it treated? ( 21344692 )
2011
21
Complex regional pain syndrome/reflex sympathetic dystrophy. ( 20504141 )
2010
22
Reply: Is reflex sympathetic dystrophy/complex regional pain syndrome type I a small-fiber neuropathy? ( 20583223 )
2010
23
A hypothesis for the cause of complex regional pain syndrome-type I (reflex sympathetic dystrophy): pain due to deep-tissue microvascular pathology. ( 20704671 )
2010
24
Reflex sympathetic dystrophy in patients with metastatic renal cell carcinoma treated with everolimus. ( 19649567 )
2010
25
A severe case of complex regional pain syndrome I (reflex sympathetic dystrophy) managed with spinal cord stimulation. ( 19863748 )
2010
26
Is reflex sympathetic dystrophy/complex regional pain syndrome type I a small-fiber neuropathy? ( 19557864 )
2009
27
Reflex sympathetic dystrophy secondary to deep venous thrombosis mimicking post-thrombotic syndrome. ( 19363611 )
2009
28
The efficacy of manual lymphatic drainage therapy in the management of limb edema secondary to reflex sympathetic dystrophy. ( 19030864 )
2009
29
Reflex sympathetic dystrophy: complex regional pain syndrome type I in children with mitochondrial disease and maternal inheritance. ( 18192313 )
2008
30
Reflex sympathetic dystrophy/complex regional pain syndrome. ( 18306652 )
2008
31
Unilateral trachyonychia in a patient with reflex sympathetic dystrophy. ( 18222330 )
2008
32
Factitious lymphoedema as a psychiatric condition mimicking reflex sympathetic dystrophy: a case report. ( 18577230 )
2008
33
Complex regional pain syndrome (reflex sympathetic dystrophy) in a patient with essential mixed cryoglobulinemia and chronic hepatitis C. ( 17370795 )
2007
34
Unusual cases of acquired leukonychia totalis and partialis secondary to reflex sympathetic dystrophy. ( 17958875 )
2007
35
Complex regional pain syndrome I (reflex sympathetic dystrophy) associated with a superficial hand burn from a fan heater. ( 17535413 )
2007
36
The effect of gabapentin in earlier stage of reflex sympathetic dystrophy. ( 16897121 )
2007
37
Reflex sympathetic dystrophy: a retrospective epidemiological study of 168 patients. ( 17221145 )
2007
38
Effects of weather changes on a patient with reflex sympathetic dystrophy. ( 17387368 )
2007
39
Reflex sympathetic dystrophy in a renal transplant patient treated with sirolimus. ( 17575313 )
2007
40
Reflex sympathetic dystrophy: a case of total body pain. ( 17721352 )
2007
41
Reflex sympathetic dystrophy: reflections from a clinician. ( 18605399 )
2007
42
Reflex sympathetic dystrophy in hemiplegia. ( 17106342 )
2006
43
Evidence of focal small-fiber axonal degeneration in complex regional pain syndrome-I (reflex sympathetic dystrophy). ( 16427737 )
2006
44
Impact of three-phase bone scintigraphy on the diagnosis and treatment of complex regional pain syndrome type I or reflex sympathetic dystrophy. ( 16340227 )
2006
45
Current management of reflex sympathetic dystrophy syndrome (complex regional pain syndrome type I). ( 16837228 )
2006
46
Determination of inflammation of reflex sympathetic dystrophy at early stages with Tc-99m HIG scintigraphy: preliminary results. ( 16025330 )
2006
47
Sympathetic skin responses in reflex sympathetic dystrophy. ( 16328419 )
2006
48
Spinal cord stimulation for chronic reflex sympathetic dystrophy--five-year follow-up. ( 16738284 )
2006
49
The role of the pain psychologist, trigger point injections, reflex sympathetic dystrophy. ( 17182517 )
2006
50
Psychiatric approach in the treatment of reflex sympathetic dystrophy in an adolescent girl: a case report. ( 17290576 )
2006

Variations for Algoneurodystrophy

Expression for Algoneurodystrophy

Search GEO for disease gene expression data for Algoneurodystrophy.

Pathways for Algoneurodystrophy

Pathways related to Algoneurodystrophy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.8 GGT1 GGT2
2 10.34 GGT1 GGT2
3 9.98 GGT1 GGT2

GO Terms for Algoneurodystrophy

Biological processes related to Algoneurodystrophy according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 response to estradiol GO:0032355 9.51 GGT1 GGT2
2 regulation of inflammatory response GO:0050727 9.49 GGT1 GGT2
3 cellular amino acid metabolic process GO:0006520 9.48 GGT1 GGT2
4 glutathione metabolic process GO:0006749 9.46 GGT1 GGT2
5 response to tumor necrosis factor GO:0034612 9.43 GGT1 GGT2
6 glutamate metabolic process GO:0006536 9.4 GGT1 GGT2
7 zymogen activation GO:0031638 9.37 GGT1 GGT2
8 cysteine biosynthetic process GO:0019344 9.32 GGT1 GGT2
9 regulation of immune system process GO:0002682 9.26 GGT1 GGT2
10 peptide modification GO:0031179 9.16 GGT1 GGT2
11 glutathione catabolic process GO:0006751 9.13 GGT1 GGT2 GGTLC3
12 leukotriene D4 biosynthetic process GO:1901750 8.8 GGT1 GGT2 GGTLC3

Molecular functions related to Algoneurodystrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidyltransferase activity GO:0000048 8.96 GGT1 GGT2
2 glutathione hydrolase activity GO:0036374 8.8 GGT1 GGT2 GGTLC3

Sources for Algoneurodystrophy

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35 ICD10 via Orphanet
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