MCID: ALG001
MIFTS: 39

Algoneurodystrophy

Categories: Neuronal diseases

Aliases & Classifications for Algoneurodystrophy

MalaCards integrated aliases for Algoneurodystrophy:

Name: Algoneurodystrophy 12 15 73
Reflex Sympathetic Dystrophy 73

Classifications:



External Ids:

Disease Ontology 12 DOID:14022
ICD10 33 M89.0 M89.00
ICD9CM 35 733.7
UMLS 73 C0205930

Summaries for Algoneurodystrophy

MalaCards based summary : Algoneurodystrophy, also known as reflex sympathetic dystrophy, is related to reflex sympathetic dystrophy and prolactin producing pituitary tumor. An important gene associated with Algoneurodystrophy is LCAT (Lecithin-Cholesterol Acyltransferase), and among its related pathways/superpathways are Arachidonic acid metabolism and NRF2 pathway. The drugs Lidocaine and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and spinal cord, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Complex regional pain syndrome (CRPS), also known as reflex sympathetic dystrophy (RSD) or... more...

Related Diseases for Algoneurodystrophy

Graphical network of the top 20 diseases related to Algoneurodystrophy:



Diseases related to Algoneurodystrophy

Symptoms & Phenotypes for Algoneurodystrophy

GenomeRNAi Phenotypes related to Algoneurodystrophy according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.32 GGT2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.32 GGT1 GGT2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-131 9.32 GGT2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-143 9.32 GGT1 GGT2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.32 GGT1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-24 9.32 GGT2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.32 GGT1 GGT2

Drugs & Therapeutics for Algoneurodystrophy

Drugs for Algoneurodystrophy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 142)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4,Not Applicable 137-58-6 3676
2
Bupivacaine Approved, Investigational Phase 4,Phase 3,Not Applicable 2180-92-9, 38396-39-3 2474
3
Triamcinolone Approved, Vet_approved Phase 4,Phase 3 124-94-7 31307
4
Gabapentin Approved, Investigational Phase 4,Not Applicable 60142-96-3 3446
5
Salmon Calcitonin Approved, Investigational Phase 4 47931-85-1 16129616
6
gamma-Aminobutyric acid Approved, Investigational Phase 4,Not Applicable 56-12-2 119
7
Vitamin C Approved, Nutraceutical Phase 4,Phase 3,Not Applicable 50-81-7 5785 54670067
8
Calcitonin gene-related peptide Investigational Phase 4 83652-28-2
9 triamcinolone acetonide Phase 4,Phase 3
10 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
11 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable
12 Micronutrients Phase 4,Phase 3,Not Applicable
13 Neurotransmitter Agents Phase 4,Phase 2,Not Applicable
14 Anesthetics Phase 4,Phase 3,Phase 2,Not Applicable
15 Trace Elements Phase 4,Phase 3,Not Applicable
16 Anesthetics, Local Phase 4,Phase 3,Phase 2,Not Applicable
17 Triamcinolone diacetate Phase 4,Phase 3
18 Triamcinolone hexacetonide Phase 4,Phase 3
19 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
20 Vitamins Phase 4,Phase 3,Not Applicable
21 Antioxidants Phase 4,Phase 3,Not Applicable
22 Protective Agents Phase 4,Phase 3,Not Applicable
23 Psychotropic Drugs Phase 4,Phase 2,Not Applicable
24 Bone Density Conservation Agents Phase 4,Phase 2,Phase 3
25 calcitonin Phase 4
26 calcium channel blockers Phase 4,Phase 2,Not Applicable
27 GABA Agents Phase 4,Not Applicable
28 Sodium Channel Blockers Phase 4,Not Applicable
29 Tranquilizing Agents Phase 4,Phase 2,Not Applicable
30 Diuretics, Potassium Sparing Phase 4,Not Applicable
31 Anti-Anxiety Agents Phase 4,Phase 2,Not Applicable
32 Anti-Arrhythmia Agents Phase 4,Phase 2,Not Applicable
33 Vasodilator Agents Phase 4,Phase 2
34 Excitatory Amino Acid Antagonists Phase 4,Phase 2,Not Applicable
35 Excitatory Amino Acids Phase 4,Phase 2,Not Applicable
36 Anticonvulsants Phase 4,Phase 2,Not Applicable
37 Antiparkinson Agents Phase 4,Not Applicable
38 Antimanic Agents Phase 4,Not Applicable
39 Calcium, Dietary Phase 4,Phase 3,Phase 2,Not Applicable
40
Zoledronic acid Approved Phase 3,Phase 2 118072-93-8 68740
41
Ropivacaine Approved Phase 3,Not Applicable 84057-95-4 71273 175805
42
Levobupivacaine Approved, Investigational Phase 3,Not Applicable 27262-47-1 92253
43
Hydrocodone Approved, Illicit Phase 3 125-29-1 5284569
44
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3,Not Applicable 437-38-7 3345
45
Guaifenesin Approved, Investigational, Vet_approved Phase 3 93-14-1 3516
46
Citric Acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
47
Imidacloprid Vet_approved Phase 3 105827-78-9 86418
48 Rho(D) Immune Globulin Phase 3
49 gamma-Globulins Phase 3
50 Analgesics, Non-Narcotic Phase 3,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 133)
# Name Status NCT ID Phase Drugs
1 Prophylactic Administration of Vitamin C in Wrist Fractures Completed NCT00296868 Phase 4 ascorbic acid (vitamin C) versus placebo
2 Restore Claims Characterization Study Completed NCT00200122 Phase 4
3 A Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions Completed NCT00904202 Phase 4 Placebo Capsules + Placebo Patch;Placebo capsules + Lidoderm®;Gabapentin + Placebo;Gabapentin + Lidoderm®;Gabapentin 300 mg capsules 1800 mg/day + placebo patch;Gabapentin 1800 mg/day + Lidoderm patch
4 High Frequency Stimulation Trials in Patients With Precision Spinal Cord Stimulator System Completed NCT02265848 Phase 4
5 Bupivacaine Versus Lidocaine Local Anesthesia Completed NCT01751347 Phase 4 Bupivacaine;Lidocaine
6 Efficacy and Safety of Salmon Calcitonin Nasal Spray in Improving Muscle Strength and Reducing Pain After Forearm Fracture in Postmenopausal Women Completed NCT00239889 Phase 4 Salmon calcitonin
7 Tolerability of Suprascapular and Median Nerve Blocks for the Treatment of Shoulder-hand Syndrome Recruiting NCT03291197 Phase 4 Suprascapular and median nerve blocks
8 Fasciectomy vs Collagenase Injection in Recurrent Dupuytren Disease Enrolling by invitation NCT03406338 Phase 4 Collagenase Clostridium Histolyticum
9 Acupuncture for Post-stroke Shoulder-hand Syndrome Unknown status NCT02011854 Phase 2, Phase 3
10 RCT :Thoracic Sympathetic Block for the Treatment of Complex Regional Pain Syndrome I of the Upper Limb Unknown status NCT01612364 Phase 3
11 Intravenous Immunoglobulins in Complex-regional Pain Syndrome Unknown status NCT00949065 Phase 3
12 Surgical Treatment Of Complex Regional Pain Syndrome Type II (CRPS II) Unknown status NCT01392599 Phase 3
13 Analysis of Photoplethysmographic Signal in Lumbar Sympathetic Block Unknown status NCT01134289 Phase 3
14 Efficacy and Safety of Intravenous Neridronic Acid in CRPS-I Completed NCT02402530 Phase 2, Phase 3 Placebo;Neridronic acid 62.5 mg
15 Pain Exposure Physical Therapy (PEPT) Versus CBO in Patients With Complex Regional Pain Syndrome Type I (CRPS-1) Completed NCT00817128 Phase 2, Phase 3
16 A Study of the Effect of Lenalidamide on Complex Regional Pain Syndrome Type 1 Completed NCT00166452 Phase 3 Lenalidamide
17 A Confirmatory Study of Fentanyl in Participants With Post-herpetic Neuralgia, Complex Regional Pain Syndrome or Postoperative Pain Syndrome Completed NCT01008553 Phase 3 Fentanyl;Placebo
18 STRIPS: Shoulder Taping Reduces Injury and Pain in Stroke Completed NCT01062308 Phase 3
19 Study to Evaluate the Long-Term Safety of Hydrocodone Bitartrate Extended-Release Tablets (CEP-33237) in Patients Who Require Opioid Treatment for an Extended Period of Time Completed NCT01223365 Phase 3 Hydrocodone ER
20 Study to Evaluate the Efficacy and Safety of OraVescent Fentanyl Citrate Treatment for the Management of Breakthrough Pain in Opioid-Tolerant Patients With Noncancer-Related Chronic Pain Completed NCT00343733 Phase 3 OraVescent Fentanyl
21 Role of Vitamin C at 6 Months on Incidence of Complex Regional Pain Syndrome Type I in Upper Limb Surgery Recruiting NCT02390505 Phase 3 Vitamin C;Placebo
22 Efficacy and Safety of Intravenous Neridronic Acid in Complex Regional Pain Syndrome (CRPS) Recruiting NCT03560986 Phase 3 Neridronic acid;Placebo
23 Efficacy and Safety of Intravenous Neridronic Acid in CRPS Recruiting NCT03530345 Phase 3 Neridronic acid;Placebo
24 Safety of Intravenous Neridronic Acid in CRPS Active, not recruiting NCT02972359 Phase 3 Neridronic acid
25 CREATE-1: A Study to Assess the Efficacy and Safety of AXS-02 in Patients With CRPS-1 Active, not recruiting NCT02504008 Phase 3 AXS-02 (oral zoledronate);Placebo
26 Transcranial Magnetic Stimulation (TMS) Effects on Pain Perception Withdrawn NCT00349050 Phase 2, Phase 3
27 The Use of Zoledronic Acid to Complex Regional Pain Syndrome Unknown status NCT01788176 Phase 2 Zoledronic acid;Placebo
28 Effect of Delta-9-Tetrahydrocannabinol on the Prevention of Chronic Pain in Patients With Acute CRPS (ETIC-Study) Unknown status NCT00377468 Phase 2 Delta9-Tetrahydrocannabinol
29 Dupuytren's Disease and Extracorporeal Shockwave Therapy (DupuyShock-2010) Unknown status NCT01184586 Phase 2
30 Amitriptyline Regarding Nimesulide in Acute Idiopathic Adhesive Capsulitis Completed NCT01306708 Phase 2 amitriptyline
31 A Study of CC-5013 in the Treatment of Complex Regional Pain Syndrome (CRPS) Completed NCT00067743 Phase 2 Lenalidomide
32 Prospective, Randomized Controlled Trial on Perioperative Pregabalin to Reduce Late-onset CRPS After TKA Completed NCT00558753 Phase 2 pregabalin;Placebo
33 Double Blind Placebo Controlled Study of Outpatient Intravenous Ketamine for the Treatment of CRPS Completed NCT00579085 Phase 2 Ketamine
34 Novel Treatment Option for Neuropathic Pain Completed NCT02490436 Phase 2 Cetuximab;Placebo
35 Study of HC-58 in Upper Limb Hemiplegic Patients After Stroke Completed NCT01623622 Phase 2 HC-58;Placebo
36 A Pilot Trial of IV Pamidronate for Low Back Pain Completed NCT01210599 Phase 1, Phase 2 Pamidronate
37 Effects of Vaporized Marijuana on Neuropathic Pain Completed NCT01037088 Phase 1, Phase 2 Mild dose cannabis;Low dose cannabis;Cannabis
38 Clonidine Versus Adenosine to Treat Neuropathic Pain Completed NCT00349921 Phase 2 clonidine;adenosine;placebo;placebo
39 Adipose Stem/Stromal Cells in RSD, CRPS, Fibromyalgia Recruiting NCT02987855 Phase 1, Phase 2
40 Study to Evaluate the Efficacy and Safety of Lenalidomide in the Treatment of Complex Regional Pain Syndrome Type 1 Terminated NCT00109772 Phase 2 lenalidomide;Placebo
41 Randomized Controlled Trial of Ketamine Infusion With Continuous Epidural Infusion for Treatment of Complex Regional Pain Syndrome Terminated NCT02094352 Phase 2 Ketamine Infusion + Epidural Infusion;Control Group + Epidural infusion;Ketamine Booster Infusion;Control Group Booster Infusion
42 Safety and Efficacy Study of Ethosuximide for the Treatment of Complex Regional Pain Syndrome (CRPS) Terminated NCT00689585 Phase 2 Placebo;Ethosuximide
43 Neurotropin to Treat Chronic Neuropathic Pain Terminated NCT00006289 Phase 2 Placebo;Neurotropin
44 Efficacy of Etoricoxib on Peripheral Hyperalgesia Terminated NCT01088256 Phase 2 Etoricoxib;placebo
45 Single-portal Endoscopic Carpal Tunnel Release Versus Knifelight for Carpal Tunnel Syndrome. A Randomized Control Trial Withdrawn NCT01756820 Phase 2
46 Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain. Suspended NCT02321566 Phase 1
47 Two Measures of Tactile Acuity in CRPS Type I Patients Unknown status NCT01888783 Not Applicable
48 Effects of Repetitive Electric Sensory Stimulation (RSS) as Intervention in Complex-regional-pain-syndrome Type I (CRPS) Unknown status NCT01915329 Not Applicable
49 The Effect of Vitamin c on Preventing Complex Regional Pain Syndrome (CRPS Type I) Following Ankle Fracture Unknown status NCT01338129 Not Applicable placebo
50 Use of Compression Glove to Prevent Complications After Distal Radius Fractures: a Randomized Controlled Trial Unknown status NCT01118715 Not Applicable

Search NIH Clinical Center for Algoneurodystrophy

Genetic Tests for Algoneurodystrophy

Anatomical Context for Algoneurodystrophy

MalaCards organs/tissues related to Algoneurodystrophy:

41
Bone, Skin, Spinal Cord, Cortex, Dorsal Root Ganglion, Heart, Testes

Publications for Algoneurodystrophy

Articles related to Algoneurodystrophy:

(show top 50) (show all 516)
# Title Authors Year
1
How a Simple Ankle Sprain Turned Into Neuropathic Pain: Complex Reflex Sympathetic Dystrophy Versus Erythromelalgia. ( 29121832 )
2017
2
Pain, Complex Regional Pain Syndrome (Reflex Sympathetic Dystrophy, RSD, CRPS) ( 28613470 )
2017
3
Bone SPECT/CT Localizes Increased Bone Metabolism and Subsequent Bone Resorption in Reflex Sympathetic Dystrophy. ( 28806248 )
2017
4
The Relation Between Reflex Sympathetic Dystrophy Syndrome and Trauma Severity in Patients With Distal Tibia Fracture. ( 27626009 )
2016
5
Re: del Pinal F. Editorial: I have a dream ... reflex sympathetic dystrophy (RSD or Complex Regional Pain Syndrome - CRPS I) does not exist. J Hand Surg Eur. 2013, 38: 595-7. ( 24566455 )
2014
6
Re: del Pinal F. Editorial: I have a dream ... reflex sympathetic dystrophy (RSD or Complex Regional Pain Syndrome - CRPS I) does not exist. J Hand Surg Eur. 2013, 38: 595-7. ( 24448795 )
2014
7
Reflex sympathetic dystrophy-like syndrome, possibly caused by aripiprazole, in an adolescent patient. ( 25020186 )
2014
8
Sympathomimetic amine therapy found effective for treatment of refractory chronic complex regional pain syndrome (reflex sympathetic dystrophy). ( 25134306 )
2014
9
Re: del PiA+al F. Editorial: I have a dream ... reflex sympathetic dystrophy (RSD or Complex Regional Pain Syndrome--CRPS 1) does not exist. J Hand Surg Eur. 2013, 38: 595-7. ( 24158709 )
2013
10
Editorial. I have a dream ... reflex sympathetic dystrophy (RSD or Complex Regional Pain Syndrome - CRPS I) does not exist. ( 23778064 )
2013
11
A case of linear morphoea mistaken for reflex sympathetic dystrophy. ( 23546034 )
2013
12
Unilateral Beau's lines in a case of complex regional pain syndrome (reflex sympathetic dystrophy). ( 23075662 )
2012
13
Reflex sympathetic dystrophy syndrome in a child. ( 21993705 )
2011
14
My sister fell and injured her shoulder a few months ago. She's developed terrible burning pain down into her arm. Her doctor says she has complex regional pain syndrome, also known as reflex sympathetic dystrophy. What is it? How is it treated? ( 21344692 )
2011
15
Reflex sympathetic dystrophy following pacemaker insertion. ( 22334977 )
2011
16
Tenosynovitis caused by a pseudallescheria boydii infection and symptoms of reflex sympathetic dystrophy after a dog bite. ( 21946460 )
2011
17
Lawsuit verdicts and settlements involving reflex sympathetic dystrophy and complex regional pain syndrome. ( 22214139 )
2011
18
Induction of prolonged mania during ketamine therapy for reflex sympathetic dystrophy. ( 21529780 )
2011
19
Is this complex regional pain syndrome or reflex sympathetic dystrophy? ( 21632229 )
2011
20
Reply: Is reflex sympathetic dystrophy/complex regional pain syndrome type I a small-fiber neuropathy? ( 20583223 )
2010
21
Complex regional pain syndrome/reflex sympathetic dystrophy. ( 20504141 )
2010
22
A hypothesis for the cause of complex regional pain syndrome-type I (reflex sympathetic dystrophy): pain due to deep-tissue microvascular pathology. ( 20704671 )
2010
23
A severe case of complex regional pain syndrome I (reflex sympathetic dystrophy) managed with spinal cord stimulation. ( 19863748 )
2010
24
Reflex sympathetic dystrophy in patients with metastatic renal cell carcinoma treated with everolimus. ( 19649567 )
2010
25
Is reflex sympathetic dystrophy/complex regional pain syndrome type I a small-fiber neuropathy? ( 19557864 )
2009
26
The efficacy of manual lymphatic drainage therapy in the management of limb edema secondary to reflex sympathetic dystrophy. ( 19030864 )
2009
27
Reflex sympathetic dystrophy secondary to deep venous thrombosis mimicking post-thrombotic syndrome. ( 19363611 )
2009
28
Reflex sympathetic dystrophy: complex regional pain syndrome type I in children with mitochondrial disease and maternal inheritance. ( 18192313 )
2008
29
Factitious lymphoedema as a psychiatric condition mimicking reflex sympathetic dystrophy: a case report. ( 18577230 )
2008
30
Reflex sympathetic dystrophy/complex regional pain syndrome. ( 18306652 )
2008
31
Unilateral trachyonychia in a patient with reflex sympathetic dystrophy. ( 18222330 )
2008
32
Complex regional pain syndrome (reflex sympathetic dystrophy) in a patient with essential mixed cryoglobulinemia and chronic hepatitis C. ( 17370795 )
2007
33
The effect of gabapentin in earlier stage of reflex sympathetic dystrophy. ( 16897121 )
2007
34
Unusual cases of acquired leukonychia totalis and partialis secondary to reflex sympathetic dystrophy. ( 17958875 )
2007
35
Complex regional pain syndrome I (reflex sympathetic dystrophy) associated with a superficial hand burn from a fan heater. ( 17535413 )
2007
36
Reflex sympathetic dystrophy: a case of total body pain. ( 17721352 )
2007
37
Reflex sympathetic dystrophy: a retrospective epidemiological study of 168 patients. ( 17221145 )
2007
38
Effects of weather changes on a patient with reflex sympathetic dystrophy. ( 17387368 )
2007
39
Reflex sympathetic dystrophy: reflections from a clinician. ( 18605399 )
2007
40
Reflex sympathetic dystrophy in a renal transplant patient treated with sirolimus. ( 17575313 )
2007
41
The role of the pain psychologist, trigger point injections, reflex sympathetic dystrophy. ( 17182517 )
2006
42
Spinal cord stimulation for chronic reflex sympathetic dystrophy--five-year follow-up. ( 16738284 )
2006
43
Current management of reflex sympathetic dystrophy syndrome (complex regional pain syndrome type I). ( 16837228 )
2006
44
Impact of three-phase bone scintigraphy on the diagnosis and treatment of complex regional pain syndrome type I or reflex sympathetic dystrophy. ( 16340227 )
2006
45
Evidence of focal small-fiber axonal degeneration in complex regional pain syndrome-I (reflex sympathetic dystrophy). ( 16427737 )
2006
46
Determination of inflammation of reflex sympathetic dystrophy at early stages with Tc-99m HIG scintigraphy: preliminary results. ( 16025330 )
2006
47
Psychiatric approach in the treatment of reflex sympathetic dystrophy in an adolescent girl: a case report. ( 17290576 )
2006
48
Reflex sympathetic dystrophy in hemiplegia. ( 17106342 )
2006
49
Interobserver reproducibility in the interpretation of bone scans from patients suspected of having reflex sympathetic dystrophy. ( 15604958 )
2005
50
The challenge to manage reflex sympathetic dystrophy/complex regional pain syndrome. ( 16139630 )
2005

Variations for Algoneurodystrophy

Expression for Algoneurodystrophy

Search GEO for disease gene expression data for Algoneurodystrophy.

GO Terms for Algoneurodystrophy

Cellular components related to Algoneurodystrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 8.92 CALCA GGT1 LCAT NGF

Biological processes related to Algoneurodystrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zymogen activation GO:0031638 9.16 GGT1 GGT2
2 glutathione catabolic process GO:0006751 8.96 GGT1 GGT2
3 leukotriene D4 biosynthetic process GO:1901750 8.62 GGT1 GGT2

Molecular functions related to Algoneurodystrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutathione hydrolase activity GO:0036374 8.62 GGT1 GGT2

Sources for Algoneurodystrophy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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