MCID: ALG001
MIFTS: 38

Algoneurodystrophy

Categories: Neuronal diseases

Aliases & Classifications for Algoneurodystrophy

MalaCards integrated aliases for Algoneurodystrophy:

Name: Algoneurodystrophy 12 15 72 33
Reflex Sympathetic Dystrophy 72

Classifications:



External Ids:

Disease Ontology 12 DOID:14022
ICD9CM 35 733.7
SNOMED-CT 68 7359008
ICD10 33 M89.0 M89.00
UMLS 72 C0034931 C0205930

Summaries for Algoneurodystrophy

MalaCards based summary : Algoneurodystrophy, also known as reflex sympathetic dystrophy, is related to reflex sympathetic dystrophy and prolactin producing pituitary tumor. An important gene associated with Algoneurodystrophy is LCAT (Lecithin-Cholesterol Acyltransferase), and among its related pathways/superpathways are Busulfan Pathway, Pharmacodynamics and Eicosanoid Synthesis. The drugs Bupivacaine and Gabapentin have been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and skin.

Wikipedia : 75 Complex regional pain syndrome (CRPS), also known as reflex sympathetic dystrophy (RSD), is a disorder... more...

Related Diseases for Algoneurodystrophy

Graphical network of the top 20 diseases related to Algoneurodystrophy:



Diseases related to Algoneurodystrophy

Symptoms & Phenotypes for Algoneurodystrophy

Drugs & Therapeutics for Algoneurodystrophy

Drugs for Algoneurodystrophy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 123)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
2
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
3
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
4
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 54670067 5785
5 Micronutrients Phase 4
6 Trace Elements Phase 4
7 Antioxidants Phase 4
8 Vitamins Phase 4
9 Nutrients Phase 4
10 Protective Agents Phase 4
11 Anticonvulsants Phase 4
12 Tranquilizing Agents Phase 4
13 Anti-Anxiety Agents Phase 4
14 Antimanic Agents Phase 4
15 Excitatory Amino Acid Antagonists Phase 4
16 Psychotropic Drugs Phase 4
17 Excitatory Amino Acids Phase 4
18 triamcinolone acetonide Phase 4
19 Triamcinolone diacetate Phase 4
20 Triamcinolone hexacetonide Phase 4
21
Levobupivacaine Approved, Investigational Phase 3 27262-47-1 92253
22
Ropivacaine Approved Phase 3 84057-95-4 71273 175805
23
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
24
Zoledronic Acid Approved Phase 3 118072-93-8 68740
25
Nitrous oxide Approved, Vet_approved Phase 3 10024-97-2 948
26
Imidacloprid Vet_approved Phase 3 105827-78-9 86418
27 Immunologic Factors Phase 3
28 Pharmaceutical Solutions Phase 3
29 Antibodies Phase 3
30 gamma-Globulins Phase 3
31 Immunoglobulins Phase 3
32 Immunoglobulins, Intravenous Phase 3
33 Rho(D) Immune Globulin Phase 3
34 Narcotics Phase 3
35 Analgesics, Opioid Phase 3
36 Anesthetics, Intravenous Phase 3
37 Adjuvants, Anesthesia Phase 3
38 Peripheral Nervous System Agents Phase 3
39 Analgesics Phase 3
40 Central Nervous System Depressants Phase 3
41 Anesthetics Phase 3
42 Anesthetics, General Phase 3
43 Analgesics, Non-Narcotic Phase 3
44 Anesthetics, Inhalation Phase 3
45 Diphosphonates Phase 3
46 Bone Density Conservation Agents Phase 3
47
Dronabinol Approved, Illicit Phase 2 1972-08-3 16078
48
Cetuximab Approved Phase 2 205923-56-4 56842117 2333
49
Pregabalin Approved, Illicit, Investigational Phase 2 148553-50-8 5486971
50
Clonidine Approved Phase 2 4205-90-7 2803

Interventional clinical trials:

(show top 50) (show all 114)
# Name Status NCT ID Phase Drugs
1 Restore Claims Characterization Study Completed NCT00200122 Phase 4
2 Prophylactic Administration of Vitamin C in Wrist Fractures; a Randomized Placebo Controlled Multicentre Dose-Finding Study of the Incidence of Complex Regional Pain Syndrome Completed NCT00296868 Phase 4 ascorbic acid (vitamin C) versus placebo
3 Assessing the Tolerability of Suprascapular and Median Nerve Blocks for the Treatment of Shoulder-hand Syndrome - a Feasibility Study Completed NCT03291197 Phase 4 Suprascapular and median nerve blocks
4 A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions Completed NCT00904202 Phase 4 Placebo Capsules + Placebo Patch;Placebo capsules + Lidoderm®;Gabapentin + Placebo;Gabapentin + Lidoderm®;Gabapentin 300 mg capsules 1800 mg/day + placebo patch;Gabapentin 1800 mg/day + Lidoderm patch
5 Single Blinded, Randomized Control Trial of High Frequency Stimulation in Subjects With Precision® Spinal Cord Stimulator System to Assess Efficacy and Preferability in Back and Extremity Pain Relief Completed NCT02265848 Phase 4
6 Acupuncture and Traditional Chinese Medicine Combined With Rehabilitation Therapy for Post-stroke Shoulder-hand Syndrome in Community Hospital: a Multicenter,Randomized,Controlled Trial Unknown status NCT02011854 Phase 2, Phase 3
7 An Analysis of Photoplethysmographic Signal in Diagnostic Lumbar Sympathetic Block for Complex Regional Pain Syndrome Unknown status NCT01134289 Phase 3
8 Surgical Treatment of Complex Regional Pain Syndrome Type II (CRPS II) by Regional Subcutaneous Venous Sympathectomy Unknown status NCT01392599 Phase 3
9 Role of Vitamin C at 6 Months on Incidence of Complex Regional Pain Syndrome Type I in Upper Limb Surgery Unknown status NCT02390505 Phase 3 Vitamin C;Placebo
10 Prospective, Double-blind, Randomised, Placebo-controlled, Cross-over Study to Investigate the Effect of Intravenous Immunoglobulins on Complex Regional Pain Syndrome (CRPS, M. Sudeck) Unknown status NCT00949065 Phase 3
11 Double-Blind Randomized Controlled Trial: Thoracic Sympathetic Block for the Treatment of Complex Regional Pain Syndrome I of the Upper Limb Unknown status NCT01612364 Phase 3
12 Open-label Safety Trial of Intravenous Neridronic Acid in Subjects With Complex Regional Pain Syndrome (CRPS) Completed NCT02972359 Phase 3 Neridronic acid
13 Multicenter, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Lenalidamide in the Treatment of Complex Regional Pain Syndrome Type1 Completed NCT00166452 Phase 3 Lenalidamide
14 A Randomized, Double-blind Trial Investigating the Efficacy and Safety of Intravenous Neridronic Acid in Subjects With Complex Regional Pain Syndrome Type I (CRPS-I) Completed NCT02402530 Phase 2, Phase 3 Placebo;Neridronic acid 62.5 mg
15 A Verification Study of JNS020QD in Patients With Post-herpetic Neuralgia, Complex Regional Pain Syndrome (CRPS) or Postoperative Pain Syndrome Completed NCT01008553 Phase 3 Fentanyl;Placebo
16 Pain Exposure Physical Therapy Or Conservative Therapy for Patients With Complex Regional Pain Syndrome Type I Completed NCT00817128 Phase 2, Phase 3
17 The Effectiveness of Taping Technique Versus Conventional Techniques in Prevention of Shoulder Injuries in Patients With Acute Stroke-A Prospective, Randomized, Interventional, Outcome Blinded (PROBE Design), Parallel Design Trial Completed NCT01062308 Phase 3
18 CREATE-1 Study: CRPS Treatment Evaluation 1 Study. A Randomized, Double-blind, Placebo-controlled Study to Assess the Efficacy and Safety of AXS-02 (Oral Zoledronate) Administered Orally to Subjects With Complex Regional Pain Syndrome Type I (CRPS-I) Active, not recruiting NCT02504008 Phase 3 AXS-02 (oral zoledronate);Placebo
19 A Prospective Randomized Controlled Pilot Study Nitrous Oxide for the Treatment of Complex Regional Pain Syndrome Enrolling by invitation NCT03879538 Phase 3 Nitrous Oxide;Oxygen
20 Randomized, Double-blind, Placebo-controlled Trial Investigating the Efficacy and Safety of Intravenous Neridronic Acid in Subjects With Complex Regional Pain Syndrome (CRPS) Terminated NCT03530345 Phase 3 Neridronic acid;Placebo
21 Placebo-controlled Efficacy and Safety Trial of Intravenous Neridronic Acid in Subjects With Complex Regional Pain Syndrome (CRPS) Terminated NCT03560986 Phase 3 Neridronic acid;Placebo
22 Transcranial Magnetic Stimulation (TMS) Effects on Pain Perception Withdrawn NCT00349050 Phase 2, Phase 3
23 Phase 2 Study - The Use of a Single 5 mg Dose of Zoledronic Acid in Complex Regional Pain Syndrome Patient. Unknown status NCT01788176 Phase 2 Zoledronic acid;Placebo
24 Low Dose Administration of Delta9-Tetrahydrocannabinol for the Prevention of Hyperalgesia and Chronic Pain in Patients With Acute Complex Regional Pain Syndrome (CRPS) of the Upper Limb Unknown status NCT00377468 Phase 2 Delta9-Tetrahydrocannabinol
25 Treatment Of Chronic Pain Using Real-time Functional MRI Trial Unknown status NCT00528346 Phase 2
26 A Multicenter, Open-Label Study to Evaluate the Preliminary Safety and Efficacy of CC-5013 in the Treatment of Complex Regional Pain Syndrome (CRPS) Completed NCT00067743 Phase 2 Lenalidomide
27 A Randomized, Cross-over, Placebo-controlled, Double-blind, Single-center, Phase II Study of Cetuximab in Patients With Treatment-refractory, Non-malignant Severe Chronic Neuropathic Pain Completed NCT02490436 Phase 2 Cetuximab;Placebo
28 CCRC: The Analgesic Effect of Vaporized Cannabis on Neuropathic Pain Completed NCT01037088 Phase 1, Phase 2 Mild dose cannabis;Low dose cannabis;Cannabis
29 A Prospective, Randomized Controlled Trial on Perioperative Pregabalin to Reduce Late-onset Complex Regional Pain Syndrome After Total Knee Arthroplasty Completed NCT00558753 Phase 2 pregabalin;Placebo
30 Comparative Study Between Amitriptyline Regarding Nimesulide Associated to Nervous Blockade in the Acute Treatment of Idiopathic Adhesive Capsulitis Completed NCT01306708 Phase 2 amitriptyline
31 Double Blind Placebo Controlled Study of Outpatient Intravenous Ketamine for the Treatment of CRPS Completed NCT00579085 Phase 2 Ketamine
32 Use of Autologous Adult Adipose-Derived Stem/Stromal Cells in Reflex Sympathetic Dystrophy (RSD), Complex Regional Pain Syndrome (CRPS), and Fibromyalgia Enrolling by invitation NCT02987855 Phase 1, Phase 2
33 A Phase 2a, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety, and Tolerability of TAK-935 as an Adjunctive Therapy in Adult Subjects With Chronic Complex Regional Pain Syndrome Not yet recruiting NCT03990649 Phase 2 TAK-935;TAK-935 Placebo
34 A Single Centre. Parallel-Group, Double-Blinded, Randomized, Placebo-Controlled Pilot Clinical Trial on Ethosuximide for the Treatment of Complex Regional Pain Syndrome (CRPS) Terminated NCT00689585 Phase 2 Placebo;Ethosuximide
35 Neurotropin for Acute Dental Pain and for Chronic Neuropathic Pain Terminated NCT00006289 Phase 2 Placebo;Neurotropin
36 A Multicenter, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Lenalidomide in the Treatment of Complex Regional Pain Syndrome Type 1 Terminated NCT00109772 Phase 2 lenalidomide;Placebo
37 Randomized Controlled Trial of Subanesthetic Intravenous Ketamine Infusion in Conjunction With Continuous Epidural Infusion for Treatment of Refractory Complex Regional Pain Syndrome Terminated NCT02094352 Phase 2 Ketamine Infusion + Epidural Infusion;Control Group + Epidural infusion;Ketamine Booster Infusion;Control Group Booster Infusion
38 Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain. Terminated NCT02321566 Phase 1
39 The Effect of Vitamin c on Preventing Complex Regional Pain Syndrome (CRPS Type I) Following Ankle Fracture, Prospective Double Blind Study Unknown status NCT01338129 placebo
40 Comparison of Two Measures of Tactile Acuity in CRPS Type I Patients , Patients With a Neuropathy of the Median Nerve and Healthy Controls. Unknown status NCT01888783
41 Comparison of Gait Parameters Between Floor and Sponge Surfaces and Special Shoes in Individuals With Difficulties in Weight-bearing Unknown status NCT02742376
42 Effects of Repetitive Electric Sensory Stimulation on Sensorimotor Performance and Pain Intensity in Complex Regional Pain Syndrome Type I Unknown status NCT01915329
43 Effects of Proprioceptive Stimulation Under Visual Feedback in Patient With CRPS: An Exploratory Study Unknown status NCT02395211
44 Use of Compression Glove to Prevent Complications After Distal Radius Fractures: a Randomized Controlled Trial Unknown status NCT01118715
45 Comparison of the Efficacy of the Ultrasound With Fluoroscopy in Guidance of Lumbar Sympathetic Block: A Prospective Randomized Open-label Trial Unknown status NCT02737527 10 ml of 0.25% levobupivacaine injection for LSB
46 Capsaicin-Evoked Pain in Patients With Complex Regional Pain Syndrome Completed NCT00468390
47 TMS for CRPS - Pilot Study Completed NCT01926119
48 Evaluation of Autonomic Cardiac Function in Patients With Complex Regional Pain Syndrome Completed NCT00560131
49 Transcranial Magnetic Stimulation for CRPS Completed NCT02067273
50 Efficacy of Transdermal Fentanyl for Chronic Neuropathic Pain Completed NCT00181246 Transdermal Fentanyl

Search NIH Clinical Center for Algoneurodystrophy

Genetic Tests for Algoneurodystrophy

Anatomical Context for Algoneurodystrophy

MalaCards organs/tissues related to Algoneurodystrophy:

41
Bone, Spinal Cord, Skin, Cortex, Testes, Dorsal Root Ganglion, Bone Marrow

Publications for Algoneurodystrophy

Articles related to Algoneurodystrophy:

(show top 50) (show all 1669)
# Title Authors PMID Year
1
Associations of PTSD, chronic pain, and their comorbidity on cannabis use disorder: Results from an American nationally representative study. 38
31356731 2019
2
Ozone Therapy for Complex Regional Pain Syndrome: Review and Case Report. 38
31062104 2019
3
Electroacupuncture for Reflex Sympathetic Dystrophy after Stroke: A Meta-Analysis. 38
30826129 2019
4
The application of dual-energy computed tomography in the diagnosis of musculoskeletal disorders: a review of current concepts and applications. 38
30828774 2019
5
Complex regional pain syndrome - False hopes and miscommunications. 38
30639650 2019
6
[Mid-term results in the treatment of osteochondritis dissecans of the femoral condyles using osteochondral grafting (mosaic arthroplasty)]. 38
31312303 2019
7
Economic evaluations of physiotherapy interventions for neurological disorders: a systematic review. 38
30616401 2019
8
Posttraumatic stress disorder and chronic pain are associated with opioid use disorder: Results from a 2012-2013 American nationally representative survey. 38
29775955 2018
9
Approach to the Patient with Disproportionate Pain. 38
29799372 2018
10
Mini-plate fixation via sinus tarsi approach is superior to cannulated screw in intra-articular calcaneal fractures: A prospective randomized study. 38
30101667 2018
11
Complex Regional Pain Syndrome: What the Dermatologist Should Know. 38
29742184 2018
12
How a Simple Ankle Sprain Turned Into Neuropathic Pain: Complex Reflex Sympathetic Dystrophy Versus Erythromelalgia. 38
29121832 2018
13
Living With Chronic Pain. 38
29669658 2018
14
Operative versus nonoperative treatment of displaced intra-articular calcaneal fractures: A meta-analysis of current evidence base. 38
29245290 2017
15
Outcomes Following Isolated Posterior Interosseous Nerve Neurectomy: A Systematic Review. 38
28720049 2017
16
[Reflex sympathetic dystrophy involving the ankle and the foot in a particular pathological pregnancy: Exceptional association]. 38
28919273 2017
17
Bone SPECT/CT Localizes Increased Bone Metabolism and Subsequent Bone Resorption in Reflex Sympathetic Dystrophy. 38
28806248 2017
18
Efficacy of vitamin C in preventing complex regional pain syndrome after wrist fracture: A systematic review and meta-analysis. 38
28274883 2017
19
A Comprehensive Outcome-Specific Review of the Use of Spinal Cord Stimulation for Complex Regional Pain Syndrome. 38
27739179 2017
20
Quantitative determination of methamphetamine in oral fluid by liquid-liquid extraction and gas chromatography/mass spectrometry. 38
27022165 2017
21
Calcineurin Inhibitor-Induced Pain Syndrome in ABO-Incompatible Living Kidney Transplantation: A Case Report. 38
28104127 2017
22
The Unexpected Hand Patient. 38
28536645 2017
23
[Spinal cord stimulation in 62 patients: Retrospective evaluation]. 38
28467566 2017
24
[How I treat? complex regional pain syndrome]. 38
28387091 2016
25
Putative Physiopathological Explanation for the "Sock Sign" in Bone Scans. 38
27187731 2016
26
Successful Treatment of Complex Regional Pain Syndrome with Pseudoaneurysm Excision and Median Nerve Neurolysis. 38
27318309 2016
27
Tibiotalocalcaneal arthrodesis by using proximal humeral locking plate. 38
27519965 2016
28
Complex regional pain syndrome and dysautonomia in a 14-year-old girl responsive to therapeutic plasma exchange. 38
26011726 2016
29
Late Spontaneous Migration of a Dorsal Column Stimulator Paddle Lead. 38
27672531 2016
30
Steroid atrophy scarring treated with fat grafting in a patient with complex regional pain syndrome: A case report. 38
26735938 2016
31
The Relation Between Reflex Sympathetic Dystrophy Syndrome and Trauma Severity in Patients With Distal Tibia Fracture. 38
27626009 2016
32
Imaging in Foot and Ankle Arthritis. 38
27336451 2016
33
Operative Versus Nonoperative Treatment of Displaced Intra-Articular Calcaneal Fractures: A Meta-Analysis of Randomized Controlled Trials. 38
26371619 2016
34
Intratendinous rupture of the supraspinatus: anatomical and functional results of 24 operative cases. 38
26521196 2016
35
Management of Urinary and Fecal Incontinence in Patients With Complex Regional Pain Syndrome. 38
26516817 2016
36
Mania following ketamine abuse. 38
26869791 2016
37
Complications of Proximal Biceps Tenotomy and Tenodesis. 38
26614476 2016
38
Complex regional pain syndrome type I following pacemaker implantation. 38
26995412 2015
39
Three-Phase 99mTc-MDP Bone Scintigraphy and SPECT/CT in Pediatric Pseudodystrophy. 38
26252332 2015
40
Plate Fixation of Proximal Fifth Metatarsal Fracture. 38
26429606 2015
41
Two peg spade plate for distal radius fractures: A novel technique. 38
26538760 2015
42
[COMPLEX REGIONAL PAIN SYNDROME]. 38
26749953 2015
43
Outcome of humeral shaft fractures treated by functional cast brace. 38
26229161 2015
44
Complex regional pain syndrome type I: a comprehensive review. 38
25903457 2015
45
The role of arthroscopy for treatment of perilunate injuries. 38
25945294 2015
46
Isolated subtalar arthrodesis. 38
26280869 2015
47
Complex regional pain syndrome (CRPS) type I: historical perspective and critical issues. 38
27134625 2015
48
Outcomes of a Simple Treatment for Complex Regional Pain Syndrome Type I in Children. 38
26361462 2015
49
Neurological complications of vascular access. 38
25751556 2015
50
The complex regional pain syndrome. 38
26563805 2015

Variations for Algoneurodystrophy

Expression for Algoneurodystrophy

Search GEO for disease gene expression data for Algoneurodystrophy.

Pathways for Algoneurodystrophy

Pathways related to Algoneurodystrophy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.8 GGT2 GGT1
2 10.34 GGT2 GGT1
3 9.98 GGT2 GGT1

GO Terms for Algoneurodystrophy

Cellular components related to Algoneurodystrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.55 PPT1 LCAT GGTLC3 GGT2 GGT1
2 extracellular space GO:0005615 9.02 PPT1 NGF LCAT GGT1 CALCA
3 axon GO:0030424 8.96 PPT1 NGF

Biological processes related to Algoneurodystrophy according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 regulation of inflammatory response GO:0050727 9.49 GGT2 GGT1
2 response to tumor necrosis factor GO:0034612 9.43 GGT2 GGT1
3 zymogen activation GO:0031638 9.37 GGT2 GGT1
4 regulation of immune system process GO:0002682 9.26 GGT2 GGT1
5 cellular amino acid metabolic process GO:0006520 9.18 GGT1
6 glutathione metabolic process GO:0006749 9.16 GGT1
7 peptide modification GO:0031179 9.16 GGT2 GGT1
8 glutathione catabolic process GO:0006751 9.13 GGTLC3 GGT2 GGT1
9 glutamate metabolic process GO:0006536 9.1 GGT1
10 cysteine biosynthetic process GO:0019344 9.02 GGT1
11 leukotriene D4 biosynthetic process GO:1901750 8.8 GGTLC3 GGT2 GGT1

Molecular functions related to Algoneurodystrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidyltransferase activity GO:0000048 8.96 GGT2 GGT1
2 glutathione hydrolase activity GO:0036374 8.8 GGTLC3 GGT2 GGT1

Sources for Algoneurodystrophy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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