MCID: ALK017
MIFTS: 20

Alk-Positive Large B-Cell Lymphoma

Categories: Blood diseases, Immune diseases, Rare diseases

Aliases & Classifications for Alk-Positive Large B-Cell Lymphoma

MalaCards integrated aliases for Alk-Positive Large B-Cell Lymphoma:

Name: Alk-Positive Large B-Cell Lymphoma 59
Alk Positive Large B-Cell Lymphoma 73
Alk+ Large B-Cell Lymphoma 59
Alk+ Lbcl 59

Characteristics:

Orphanet epidemiological data:

59
alk-positive large b-cell lymphoma
Inheritance: Multigenic/multifactorial,Not applicable;

Classifications:



External Ids:

Orphanet 59 ORPHA364043
ICD10 via Orphanet 34 C83.3
UMLS 73 C1333294

Summaries for Alk-Positive Large B-Cell Lymphoma

MalaCards based summary : Alk-Positive Large B-Cell Lymphoma, also known as alk positive large b-cell lymphoma, is related to plasmablastic lymphoma and b-cell lymphomas. An important gene associated with Alk-Positive Large B-Cell Lymphoma is ALK (ALK Receptor Tyrosine Kinase). The drugs Nivolumab and Immunoglobulin G have been mentioned in the context of this disorder. Affiliated tissues include b cells and neutrophil.

Related Diseases for Alk-Positive Large B-Cell Lymphoma

Diseases related to Alk-Positive Large B-Cell Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 plasmablastic lymphoma 11.5
2 b-cell lymphomas 10.7
3 lymphoma 10.7
4 intussusception 10.2
5 ulcerative colitis 10.2
6 colitis 10.2
7 extramedullary plasmacytoma 10.2
8 plasmacytoma 10.2

Graphical network of the top 20 diseases related to Alk-Positive Large B-Cell Lymphoma:



Diseases related to Alk-Positive Large B-Cell Lymphoma

Symptoms & Phenotypes for Alk-Positive Large B-Cell Lymphoma

Drugs & Therapeutics for Alk-Positive Large B-Cell Lymphoma

Drugs for Alk-Positive Large B-Cell Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nivolumab Approved Phase 2 946414-94-4
2 Immunoglobulin G Phase 2
3 Antibodies, Monoclonal Phase 2
4 Immunologic Factors Phase 2
5 Antibodies Phase 2
6 Immunoglobulins Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Nivolumab With or Without Varlilumab in Treating Patients With Relapsed or Refractory Aggressive B-cell Lymphomas Recruiting NCT03038672 Phase 2 Varlilumab

Search NIH Clinical Center for Alk-Positive Large B-Cell Lymphoma

Genetic Tests for Alk-Positive Large B-Cell Lymphoma

Anatomical Context for Alk-Positive Large B-Cell Lymphoma

MalaCards organs/tissues related to Alk-Positive Large B-Cell Lymphoma:

41
B Cells, Neutrophil

Publications for Alk-Positive Large B-Cell Lymphoma

Articles related to Alk-Positive Large B-Cell Lymphoma:

(show all 11)
# Title Authors Year
1
A Rare Case of ALK-Positive Large B-Cell Lymphoma with CD33 Expression. ( 29992063 )
2018
2
Identification of a novel GORASP2-ALK fusion in an ALK-positive large B-cell lymphoma. ( 30187817 )
2018
3
ALK-positive Large B-cell Lymphoma: A Clinicopathologic Study of 26 Cases With Review of Additional 108 Cases in the Literature. ( 27740969 )
2017
4
ALK-positive large B-cell lymphoma: identification of EML4-ALK and a review of the literature focusing on the ALK immunohistochemical staining pattern. ( 26781614 )
2016
5
ALK-positive large B-cell lymphoma with strong CD30 expression; a diagnostic pitfall and resistance to brentuximab and crizotinib. ( 27238948 )
2016
6
Anaplastic lymphoma kinase (ALK)-positive large B-cell lymphoma in a patient treated with azathioprine for ulcerative colitis. ( 27311871 )
2016
7
ALK positive large B-cell lymphoma with a massive neutrophilic infiltrate: report of a case mimicking epithelioid inflammatory myofibroblastic tumour. ( 25720769 )
2015
8
Plasmacytic ALK-positive large B-cell lymphoma: a potential mimic of extramedullary plasmacytoma. ( 24965113 )
2014
9
STAT3 pathway is activated in ALK-positive large B-cell lymphoma carrying SQSTM1-ALK rearrangement and provides a possible therapeutic target. ( 23588372 )
2013
10
ALK-positive large B-cell lymphoma presenting with jejunal intussusception. ( 23171433 )
2013
11
Identification of a novel fusion, SQSTM1-ALK, in ALK-positive large B-cell lymphoma. ( 21134980 )
2011

Variations for Alk-Positive Large B-Cell Lymphoma

Expression for Alk-Positive Large B-Cell Lymphoma

Search GEO for disease gene expression data for Alk-Positive Large B-Cell Lymphoma.

Pathways for Alk-Positive Large B-Cell Lymphoma

GO Terms for Alk-Positive Large B-Cell Lymphoma

Sources for Alk-Positive Large B-Cell Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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