MCID: ALK017
MIFTS: 20

Alk-Positive Large B-Cell Lymphoma

Categories: Blood diseases, Immune diseases, Rare diseases

Aliases & Classifications for Alk-Positive Large B-Cell Lymphoma

MalaCards integrated aliases for Alk-Positive Large B-Cell Lymphoma:

Name: Alk-Positive Large B-Cell Lymphoma 60
Alk Positive Large B-Cell Lymphoma 74
Alk+ Large B-Cell Lymphoma 60
Alk+ Lbcl 60

Characteristics:

Orphanet epidemiological data:

60
alk-positive large b-cell lymphoma
Inheritance: Multigenic/multifactorial,Not applicable;

Classifications:



External Ids:

ICD10 via Orphanet 35 C83.3
Orphanet 60 ORPHA364043
UMLS 74 C1333294

Summaries for Alk-Positive Large B-Cell Lymphoma

MalaCards based summary : Alk-Positive Large B-Cell Lymphoma, also known as alk positive large b-cell lymphoma, is related to plasmablastic lymphoma and lymphoma. An important gene associated with Alk-Positive Large B-Cell Lymphoma is ALK (ALK Receptor Tyrosine Kinase). The drugs nivolumab and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include b cells and neutrophil.

Related Diseases for Alk-Positive Large B-Cell Lymphoma

Diseases related to Alk-Positive Large B-Cell Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 plasmablastic lymphoma 11.5
2 lymphoma 10.7
3 b-cell lymphomas 10.4
4 intussusception 10.2
5 ulcerative colitis 10.2
6 colitis 10.2
7 extramedullary plasmacytoma 10.2
8 plasmacytoma 10.2

Graphical network of the top 20 diseases related to Alk-Positive Large B-Cell Lymphoma:



Diseases related to Alk-Positive Large B-Cell Lymphoma

Symptoms & Phenotypes for Alk-Positive Large B-Cell Lymphoma

Drugs & Therapeutics for Alk-Positive Large B-Cell Lymphoma

Drugs for Alk-Positive Large B-Cell Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2 Immunologic Factors Phase 2
3 Antineoplastic Agents, Immunological Phase 2
4 Antibodies Phase 2
5 Immunoglobulin G Phase 2
6 Immunoglobulins Phase 2
7 Antibodies, Monoclonal Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Nivolumab With or Without Varlilumab in Treating Patients With Relapsed or Refractory Aggressive B-cell Lymphomas Recruiting NCT03038672 Phase 2 Varlilumab

Search NIH Clinical Center for Alk-Positive Large B-Cell Lymphoma

Genetic Tests for Alk-Positive Large B-Cell Lymphoma

Anatomical Context for Alk-Positive Large B-Cell Lymphoma

MalaCards organs/tissues related to Alk-Positive Large B-Cell Lymphoma:

42
B Cells, Neutrophil

Publications for Alk-Positive Large B-Cell Lymphoma

Articles related to Alk-Positive Large B-Cell Lymphoma:

(show all 12)
# Title Authors Year
1
A case of ALK-positive large B-cell lymphoma ( 31099233 )
2019
2
A Rare Case of ALK-Positive Large B-Cell Lymphoma with CD33 Expression. ( 29992063 )
2018
3
Identification of a novel GORASP2-ALK fusion in an ALK-positive large B-cell lymphoma. ( 30187817 )
2018
4
ALK-positive Large B-cell Lymphoma: A Clinicopathologic Study of 26 Cases With Review of Additional 108 Cases in the Literature. ( 27740969 )
2017
5
ALK-positive large B-cell lymphoma: identification of EML4-ALK and a review of the literature focusing on the ALK immunohistochemical staining pattern. ( 26781614 )
2016
6
ALK-positive large B-cell lymphoma with strong CD30 expression; a diagnostic pitfall and resistance to brentuximab and crizotinib. ( 27238948 )
2016
7
Anaplastic lymphoma kinase (ALK)-positive large B-cell lymphoma in a patient treated with azathioprine for ulcerative colitis. ( 27311871 )
2016
8
ALK positive large B-cell lymphoma with a massive neutrophilic infiltrate: report of a case mimicking epithelioid inflammatory myofibroblastic tumour. ( 25720769 )
2015
9
Plasmacytic ALK-positive large B-cell lymphoma: a potential mimic of extramedullary plasmacytoma. ( 24965113 )
2014
10
ALK-positive large B-cell lymphoma presenting with jejunal intussusception. ( 23171433 )
2013
11
STAT3 pathway is activated in ALK-positive large B-cell lymphoma carrying SQSTM1-ALK rearrangement and provides a possible therapeutic target. ( 23588372 )
2013
12
Identification of a novel fusion, SQSTM1-ALK, in ALK-positive large B-cell lymphoma. ( 21134980 )
2011

Variations for Alk-Positive Large B-Cell Lymphoma

Expression for Alk-Positive Large B-Cell Lymphoma

Search GEO for disease gene expression data for Alk-Positive Large B-Cell Lymphoma.

Pathways for Alk-Positive Large B-Cell Lymphoma

GO Terms for Alk-Positive Large B-Cell Lymphoma

Sources for Alk-Positive Large B-Cell Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....