MCID: ALK017
MIFTS: 20

Alk-Positive Large B-Cell Lymphoma

Categories: Blood diseases, Immune diseases, Rare diseases

Aliases & Classifications for Alk-Positive Large B-Cell Lymphoma

MalaCards integrated aliases for Alk-Positive Large B-Cell Lymphoma:

Name: Alk-Positive Large B-Cell Lymphoma 58
Alk Positive Large B-Cell Lymphoma 71
Alk+ Large B-Cell Lymphoma 58
Alk+ Lbcl 58

Characteristics:

Orphanet epidemiological data:

58
alk-positive large b-cell lymphoma
Inheritance: Multigenic/multifactorial,Not applicable;

Classifications:

Orphanet: 58  
Rare haematological diseases


External Ids:

ICD10 via Orphanet 33 C83.3
Orphanet 58 ORPHA364043
UMLS 71 C1333294

Summaries for Alk-Positive Large B-Cell Lymphoma

MalaCards based summary : Alk-Positive Large B-Cell Lymphoma, also known as alk positive large b-cell lymphoma, is related to b-cell lymphoma and lymphoma. An important gene associated with Alk-Positive Large B-Cell Lymphoma is ALK (ALK Receptor Tyrosine Kinase). The drugs nivolumab and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include b cells, bone marrow and bone.

Related Diseases for Alk-Positive Large B-Cell Lymphoma

Diseases related to Alk-Positive Large B-Cell Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 b-cell lymphoma 10.8
2 lymphoma 10.7
3 diffuse large b-cell lymphoma 10.3
4 intussusception 10.2
5 colitis 10.2
6 extramedullary plasmacytoma 10.2
7 plasmacytoma 10.2
8 ulcerative colitis 10.2

Graphical network of the top 20 diseases related to Alk-Positive Large B-Cell Lymphoma:



Diseases related to Alk-Positive Large B-Cell Lymphoma

Symptoms & Phenotypes for Alk-Positive Large B-Cell Lymphoma

Drugs & Therapeutics for Alk-Positive Large B-Cell Lymphoma

Drugs for Alk-Positive Large B-Cell Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2 Immunoglobulins Phase 2
3 Antibodies Phase 2
4 Immunoglobulins, Intravenous Phase 2
5 Antibodies, Monoclonal Phase 2
6 Immunologic Factors Phase 2
7 Immunoglobulin G Phase 2
8 Antineoplastic Agents, Immunological Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized Phase 2 Study of CDX-1127 (Varlilumab) in Combination With Nivolumab in Patients With Relapsed or Refractory Aggressive B-Cell Lymphomas Recruiting NCT03038672 Phase 2 Varlilumab
2 A Phase 1 Multidose Study to Evaluate the Safety and Tolerability of XmAb13676 in Patients With CD20-Expressing Hematologic Malignancies Recruiting NCT02924402 Phase 1

Search NIH Clinical Center for Alk-Positive Large B-Cell Lymphoma

Genetic Tests for Alk-Positive Large B-Cell Lymphoma

Anatomical Context for Alk-Positive Large B-Cell Lymphoma

MalaCards organs/tissues related to Alk-Positive Large B-Cell Lymphoma:

40
B Cells, Bone Marrow, Bone, Neutrophil

Publications for Alk-Positive Large B-Cell Lymphoma

Articles related to Alk-Positive Large B-Cell Lymphoma:

(show all 39)
# Title Authors PMID Year
1
Complete Response of Primary Refractory ALK-Positive Large B-Cell Lymphoma Treated With Single-Agent Nivolumab. 61
32033930 2020
2
Diffuse large B-cell lymphoma variants: an update. 61
31735345 2020
3
Primary Cutaneous Anaplastic Lymphoma Kinase-Positive Large B-Cell Lymphoma. 61
31335416 2019
4
Epstein-Barr Virus-Positive CD20- and CD45-Negative Diffuse Large B-Cell Lymphoma: A Diagnostic Challenge. 61
29968492 2019
5
Aggressive B cell lymphomas in the 2017 revised WHO classification of tumors of hematopoietic and lymphoid tissues. 61
30380402 2019
6
Identification of a novel GORASP2-ALK fusion in an ALK-positive large B-cell lymphoma. 61
30187817 2019
7
Survival of patients with CD20-negative variants of large B-cell lymphoma: an analysis of the National Cancer Data Base. 61
29019447 2018
8
A Rare Case of ALK-Positive Large B-Cell Lymphoma with CD33 Expression. 61
29992063 2018
9
Relapsed anaplastic lymphoma kinase-positive large B-cell lymphoma expressed cluster of differentiation 4 and cytokeratin: An initially misdiagnosed case corrected by immunoglobulin κ locus gene rearrangement detection. 61
28693234 2017
10
Anaplastic lymphoma kinase positive large B-cell lymphoma: Literature review and report of an endoscopic fine needle aspiration case with tigroid backgrounds mimicking seminoma. 61
27686567 2017
11
Anaplastic lymphoma kinase-positive large B-cell lymphoma: Clinico-pathological study of 17 cases with review of literature. 61
28665943 2017
12
ALK-positive Large B-cell Lymphoma: A Clinicopathologic Study of 26 Cases With Review of Additional 108 Cases in the Literature. 61
27740969 2017
13
Anaplastic lymphoma kinase-positive large B-cell lymphoma with a diagnostic pitfall of carcinoma: a case report. 61
31966473 2017
14
Oct2 and Bob1 are sensitive and specific markers in lineage determination of B cell lymphomas with no expression of conventional B cell markers. 61
27319306 2016
15
ALK-positive large B-cell lymphoma with strong CD30 expression; a diagnostic pitfall and resistance to brentuximab and crizotinib. 61
27238948 2016
16
Anaplastic lymphoma kinase (ALK)-positive large B-cell lymphoma in a patient treated with azathioprine for ulcerative colitis. 61
27311871 2016
17
An unusual case of anaplastic lymphoma kinase-positive large B-cell lymphoma in an elderly patient: A case report and discussion. 61
27168806 2016
18
ALK-positive large B-cell lymphoma: identification of EML4-ALK and a review of the literature focusing on the ALK immunohistochemical staining pattern. 61
26781614 2016
19
An Expanded Spectrum of High-Grade B-Cell Non-Hodgkin Lymphomas Involving the Cervicovaginal Region. 61
26352550 2015
20
ALK positive large B-cell lymphoma with a massive neutrophilic infiltrate: report of a case mimicking epithelioid inflammatory myofibroblastic tumour. 61
25720769 2015
21
Anaplastic lymphoma kinase-positive large B-cell lymphoma: a potential diagnostic pitfall. 61
25885146 2015
22
Bone marrow flow cytometry in staging of patients with B-cell non-Hodgkin lymphoma. 61
25729719 2015
23
Anaplastic lymphoma kinase-positive large B-cell lymphoma: description of a case with an unexpected clinical outcome. 61
24868005 2015
24
Plasmacytic ALK-positive large B-cell lymphoma: a potential mimic of extramedullary plasmacytoma. 61
24965113 2014
25
A case of anaplastic lymphoma kinase-positive large B-cell lymphoma: aspiration cytology findings. 61
23457005 2014
26
ALK-positive large B-cell lymphomas express a terminal B-cell differentiation program and activated STAT3 but lack MYC rearrangements. 61
23599149 2013
27
STAT3 pathway is activated in ALK-positive large B-cell lymphoma carrying SQSTM1-ALK rearrangement and provides a possible therapeutic target. 61
23588372 2013
28
ALK+ large B-cell lymphoma: a rare variant of aggressive large B-cell lymphoma mimicking carcinoma on cytology specimens. 61
22351377 2013
29
ALK-positive large B-cell lymphoma presenting with jejunal intussusception. 61
23171433 2013
30
Anaplastic lymphoma kinase-positive large B-cell lymphoma: a case report with emphasis on the cytological features of the pleural effusion. 61
24228132 2013
31
[ALK positive large B-cell lymphoma: a case report]. 61
22967419 2012
32
Large B-cell lymphomas with plasmablastic differentiation: a biological and therapeutic challenge. 61
21812534 2012
33
Anaplastic lymphoma kinase-positive large B-cell lymphoma: an underrecognized aggressive lymphoma. 61
22474449 2012
34
[ALK-positive large B-cell lymphoma: report of a case]. 61
22169650 2011
35
Identification of a novel fusion, SQSTM1-ALK, in ALK-positive large B-cell lymphoma. 61
21134980 2011
36
[Pathologic and molecular genetic study of anaplastic lymphoma kinase-positive large B-cell lymphoma]. 61
21575387 2011
37
ALK-positive large B-cell lymphomas with cryptic SEC31A-ALK and NPM1-ALK fusions. 61
20207848 2010
38
Anaplastic lymphoma kinase-positive large B-cell lymphoma: a distinct clinicopathological entity. 61
19636398 2009
39
Hyperactivated STAT3 in ALK-positive diffuse large B-cell lymphoma with clathrin-ALK fusion. 61
18755494 2009

Variations for Alk-Positive Large B-Cell Lymphoma

Expression for Alk-Positive Large B-Cell Lymphoma

Search GEO for disease gene expression data for Alk-Positive Large B-Cell Lymphoma.

Pathways for Alk-Positive Large B-Cell Lymphoma

GO Terms for Alk-Positive Large B-Cell Lymphoma

Sources for Alk-Positive Large B-Cell Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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