Alkhurma Hemorrhagic Fever disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Alkhurma Hemorrhagic Fever

MalaCards integrated aliases for Alkhurma Hemorrhagic Fever:

Name: Alkhurma Hemorrhagic Fever ¹² ³ ¹⁵

Classifications:

MalaCards categories:
Global: Infectious diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0050308

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Summaries for Alkhurma Hemorrhagic Fever

CDC : ³ Alkhurma hemorrhagic fever (AHF) is caused by Alkhurma hemorrhagic fever virus (AHFV), a tick-borne virus of the Flavivirus family. The virus was initially isolated in 1995 from a patient in Saudi Arabia. Subsequent cases of AHF have been documented in tourists in Egypt, extending the geographic range of the virus and suggesting that geographic distribution of the virus is wide and that infections due to AHFV are underreported. The persistence of the virus within tick populations, and the role of livestock in the disease transmission process, are not well understood. The AHFV virus is a variant of Kyasanur Forest Disease (KFD), a tick-borne Flavivirus found in Karnataka State and environs in India. Since the first description of AHFV, several hundred cases of AHF have been reported. Cases appear to peak in spring and summer. Further study of AHFV is needed to improve public health measures.

MalaCards based summary : Alkhurma Hemorrhagic Fever is related to kyasanur forest disease and acquired hemophilia. An important gene associated with Alkhurma Hemorrhagic Fever is F8 (Coagulation Factor VIII), and among its related pathways/superpathways are Complement and coagulation cascades and Crizotinib Pathway, Pharmacokinetics/Pharmacodynamics. Affiliated tissues include skin, and related phenotypes are homeostasis/metabolism and immune system

Disease Ontology : ¹² A viral infectious disease that is a hemorrhagic fever, has material basis in Alkhurma hemorrhagic fever virus, which is transmitted by Ornithodoros savignyi tick bite, transmitted by ingestion of unpasteurized camel milk, or transmitted by entry via skin wound. The infection has symptom headache, has symptom joint pain, has symptom muscle pain, has symptom vomiting, has symptom thrombocytopenia, and has symptom hemorrhagic fever.

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Related Diseases for Alkhurma Hemorrhagic Fever

Diseases related to Alkhurma Hemorrhagic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)

#	Related Disease	Score	Top Affiliating Genes
1	kyasanur forest disease	31.1	F8 CD40LG
2	acquired hemophilia	10.3	F8 F3
3	acquired hemophilia a	10.3	F8 F3
4	hemophilia a	10.3	F8 F3
5	synovial angioma	10.3	F8 F3
6	encephalopathy, progressive, early-onset, with episodic rhabdomyolysis	10.2
7	tick-borne encephalitis	10.2
8	viral hemorrhagic fever	10.2
9	prothrombin deficiency	10.2	F8 F3
10	acquired von willebrand syndrome	10.2	F8 F3
11	alpha-2-plasmin inhibitor deficiency	10.2	F8 F3
12	vitamin k deficiency bleeding	10.2	F8 F3
13	hemarthrosis	10.2	F8 F3
14	angiodysplasia	10.2	F8 F3
15	von willebrand disease, type 1	10.2	F8 F3
16	post-thrombotic syndrome	10.2	F8 F3
17	cerebral arteritis	10.2	F8 CD40LG
18	intracranial thrombosis	10.2	F8 F3
19	thrombophilia due to activated protein c resistance	10.2	F8 F3
20	factor v deficiency	10.1	F8 F3
21	factor xiii deficiency	10.1	F8 F3
22	central retinal vein occlusion	10.1	F8 F3
23	bartonellosis	10.1	TXNDC15 CD40LG
24	factor viii deficiency	10.1	F8 F3
25	mite infestation	10.1	TXNDC15 CD40LG
26	immunoglobulin g deficiency	10.1	MBL2 CD40LG
27	polycystic echinococcosis	10.1	MIF F3
28	multicentric castleman disease	10.1	F8 F3
29	paralytic poliomyelitis	10.1	NID1 CD40LG
30	lassa fever	10.1	MBTPS1 CD40LG
31	selective igg deficiency disease	10.1	MBL2 CD40LG
32	factor xi deficiency	10.0	F8 F3
33	sporotrichosis	10.0	MBL2 CD40LG
34	coccidioidomycosis	10.0	MBL2 CD40LG
35	protein s deficiency	10.0	F8 F3
36	heparin-induced thrombocytopenia	10.0	F3 CD40LG
37	myringitis bullosa hemorrhagica	10.0	PIK3C2A CD40LG
38	astrakhan spotted fever	10.0	F3 CD40LG
39	sarcocystosis	10.0	PIK3C2A CD40LG
40	tularemia	10.0	MBL2 CD40LG
41	catastrophic antiphospholipid syndrome	10.0	F3 CD40LG
42	trichinosis	10.0	PIK3C2A CD40LG
43	ornithosis	10.0	PIK3C2A CD40LG
44	goodpasture syndrome	10.0	NID1 CD40LG
45	splenic infarction	10.0	F3 CD40LG
46	splenic sequestration	10.0	F3 CD40LG
47	rocky mountain spotted fever	9.9	F3 CD40LG
48	acute hemorrhagic encephalitis	9.9	F3 CD40LG
49	hantavirus pulmonary syndrome	9.9	F3 CD40LG
50	cysticercosis	9.9	MIF CD40LG

Graphical network of the top 20 diseases related to Alkhurma Hemorrhagic Fever:

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Symptoms & Phenotypes for Alkhurma Hemorrhagic Fever

MGI Mouse Phenotypes related to Alkhurma Hemorrhagic Fever:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	9.61	ALK CD40LG F3 F8 MBL2 MBTPS1
2	immune system	MP:0005387	9.28	CD40LG F3 F8 MBL2 MBTPS1 MIF

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Drugs & Therapeutics for Alkhurma Hemorrhagic Fever

Search Clinical Trials , NIH Clinical Center for Alkhurma Hemorrhagic Fever

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Genetic Tests for Alkhurma Hemorrhagic Fever

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Anatomical Context for Alkhurma Hemorrhagic Fever

MalaCards organs/tissues related to Alkhurma Hemorrhagic Fever:

⁴⁰

Skin

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Publications for Alkhurma Hemorrhagic Fever

Articles related to Alkhurma Hemorrhagic Fever:

(show all 25)

#	Title	Authors	PMID	Year
1	Development of a quantitative real-time RT-PCR assay that differentiates between Kyasanur Forest disease virus and Alkhurma hemorrhagic fever virus. ⁶¹	N S...Arunkumar G	32009000	2020
2	In silico analysis for development of epitopes-based peptide vaccine against Alkhurma hemorrhagic fever virus. ⁶¹	Ul-Rahman A...Shabbir MAB	31370756	2019
3	Genetic diversity of Alkhurma hemorrhagic fever virus in Western Asia. ⁶¹	Ul-Rahman A	30779959	2019
4	Structural disorder in the proteome and interactome of Alkhurma virus (ALKV). ⁶¹	Redwan EM...Uversky VN	30443749	2019
5	Defeating re-emerging Alkhurma hemorrhagic fever virus outbreak in Saudi Arabia and worldwide. ⁶¹	Tambo E...El-Dessouky AG	30260960	2018
6	Alkhurma Hemorrhagic Fever Virus RNA in Hyalomma rufipes Ticks Infesting Migratory Birds, Europe and Asia Minor. ⁶¹	Hoffman T...Salaneck E	29664386	2018
7	Dengue Hemorrhagic Fever Virus in Saudi Arabia: A Review. ⁶¹	Al-Tawfiq JA...Memish ZA	29319426	2018
8	Alkhurma hemorrhagic fever virus. ⁶¹	Al-Tawfiq JA...Memish ZA	28456648	2017
9	In vitro antiviral activity of adenosine analog NITD008 against tick-borne flaviviruses. ⁶¹	Lo MK...Spiropoulou CF	27016316	2016
10	Tick-borne viruses: a review from the perspective of therapeutic approaches. ⁶¹	Lani R...Zandi K	24907187	2014
11	Inhibitors of the tick-borne, hemorrhagic fever-associated flaviviruses. ⁶¹	Flint M...Spiropoulou CF	24663025	2014
12	Is the epidemiology of alkhurma hemorrhagic fever changing?: A three-year overview in Saudi Arabia. ⁶¹	Memish ZA...Bamgboye EA	24516520	2014
13	Kyasanur Forest disease virus infection in mice is associated with higher morbidity and mortality than infection with the closely related Alkhurma hemorrhagic fever virus. ⁶¹	Dodd KA...Spiropoulou CF	24950196	2014
14	Neglected tropical diseases of the Middle East and North Africa: review of their prevalence, distribution, and opportunities for control. ⁶¹	Hotez PJ...Fenwick A	22389729	2012
15	Controversy on virus designation: Alkhumra sive Alkhurma hemorrhagic fever flavivirus. ⁶¹	Liebert UG	22433583	2012
16	Rhabdomyolysis and severe muscular weakness in a traveler diagnosed with Alkhurma hemorrhagic fever virus infection. ⁶¹	Ravanini P...Vapalahti O	21889906	2011
17	Ancient ancestry of KFDV and AHFV revealed by complete genome analyses of viruses isolated from ticks and mammalian hosts. ⁶¹	Dodd KA...Nichol ST	21991403	2011
18	Alkhurma hemorrhagic fever in travelers returning from Egypt, 2010. ⁶¹	Charrel RN...Gould EA	21801660	2011
19	Computer-based comparison of structural features of envelope protein of Alkhurma hemorrhagic fever virus with the homologous proteins of two closest viruses. ⁶¹	Mohabatkar H	21235484	2011
20	Alkhurma hemorrhagic fever in humans, Najran, Saudi Arabia. ⁶¹	Alzahrani AG...Memish ZA	21122217	2010
21	Alkhurma hemorrhagic fever in travelers returning from Egypt, 2010. ⁶¹	Carletti F...Ippolito G	21122237	2010
22	Alkhurma hemorrhagic fever virus in Ornithodoros savignyi ticks. ⁶¹	Charrel RN...de Lamballerie X	17370534	2007
23	Alkhurma hemorrhagic fever virus is an emerging tick-borne flavivirus. ⁶¹	Charrel RN...de Lamballerie X	16216331	2006
24	Low diversity of Alkhurma hemorrhagic fever virus, Saudi Arabia, 1994-1999. ⁶¹	Charrel RN...de Lamballerie X	15890119	2005
25	[Emergence of new viruses in Asia: is climate change involved?]. ⁶¹	Chastel C	15620053	2004

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Genes for Alkhurma Hemorrhagic Fever

Genes related to Alkhurma Hemorrhagic Fever (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	F8	Coagulation Factor VIII	Protein Coding	5.92	DISEASES inferred ¹⁵
2	POLK	DNA Polymerase Kappa	Protein Coding	5.34	DISEASES inferred ¹⁵
3	PTAFR	Platelet Activating Factor Receptor	Protein Coding	5.25	DISEASES inferred ¹⁵
4	MBTPS1	Membrane Bound Transcription Factor Peptidase, Site 1	Protein Coding	5.25	DISEASES inferred ¹⁵
5	TXNDC15	Thioredoxin Domain Containing 15	Protein Coding	4.79	DISEASES inferred ¹⁵
6	NID1	Nidogen 1	Protein Coding	4.63	DISEASES inferred ¹⁵
7	MBL2	Mannose Binding Lectin 2	Protein Coding	4.43	DISEASES inferred ¹⁵
8	MIF	Macrophage Migration Inhibitory Factor	Protein Coding	4.21	DISEASES inferred ¹⁵
9	PIK3C2A	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha	Protein Coding	4.09	DISEASES inferred ¹⁵
10	CD40LG	CD40 Ligand	Protein Coding	3.7	DISEASES inferred ¹⁵
11	ALK	ALK Receptor Tyrosine Kinase	Protein Coding	3.43	DISEASES inferred ¹⁵
12	F3	Coagulation Factor III, Tissue Factor	Protein Coding	3.36	DISEASES inferred ¹⁵

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Variations for Alkhurma Hemorrhagic Fever

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Expression for Alkhurma Hemorrhagic Fever

Search GEO for disease gene expression data for Alkhurma Hemorrhagic Fever.

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Pathways for Alkhurma Hemorrhagic Fever

Pathways related to Alkhurma Hemorrhagic Fever according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Complement and coagulation cascades ³⁶ ¹	10.96	MBL2 F8 F3
2	Crizotinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	10.54	PIK3C2A ALK

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GO Terms for Alkhurma Hemorrhagic Fever

Cellular components related to Alkhurma Hemorrhagic Fever according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:0005886	9.28	TXNDC15 PTAFR PIK3C2A NID1 MIF F8
2	cell surface	GO:0009986	9.26	MIF MBL2 F3 CD40LG

Biological processes related to Alkhurma Hemorrhagic Fever according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	acute-phase response	GO:0006953	8.62	MBL2 F8

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