MCID: ALK001
MIFTS: 22

Alkhurma Hemorrhagic Fever

Categories: Infectious diseases

Aliases & Classifications for Alkhurma Hemorrhagic Fever

MalaCards integrated aliases for Alkhurma Hemorrhagic Fever:

Name: Alkhurma Hemorrhagic Fever 12 3 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050308

Summaries for Alkhurma Hemorrhagic Fever

CDC : 3 Alkhurma hemorrhagic fever (AHF) is caused by Alkhurma hemorrhagic fever virus (AHFV), a tick-borne virus of the Flavivirus family. The virus was initially isolated in 1995 from a patient in Saudi Arabia. Subsequent cases of AHF have been documented in tourists in Egypt, extending the geographic range of the virus and suggesting that geographic distribution of the virus is wide and that infections due to AHFV are underreported. The persistence of the virus within tick populations, and the role of livestock in the disease transmission process, are not well understood. The AHFV virus is a variant of Kyasanur Forest Disease (KFD), a tick-borne Flavivirus found in Karnataka State and environs in India. Since the first description of AHFV, several hundred cases of AHF have been reported. Cases appear to peak in spring and summer. Further study of AHFV is needed to improve public health measures.

MalaCards based summary : Alkhurma Hemorrhagic Fever is related to kyasanur forest disease and acquired hemophilia. An important gene associated with Alkhurma Hemorrhagic Fever is F8 (Coagulation Factor VIII), and among its related pathways/superpathways are Complement and coagulation cascades and Crizotinib Pathway, Pharmacokinetics/Pharmacodynamics. Affiliated tissues include skin, and related phenotypes are homeostasis/metabolism and immune system

Disease Ontology : 12 A viral infectious disease that is a hemorrhagic fever, has material basis in Alkhurma hemorrhagic fever virus, which is transmitted by Ornithodoros savignyi tick bite, transmitted by ingestion of unpasteurized camel milk, or transmitted by entry via skin wound. The infection has symptom headache, has symptom joint pain, has symptom muscle pain, has symptom vomiting, has symptom thrombocytopenia, and has symptom hemorrhagic fever.

Related Diseases for Alkhurma Hemorrhagic Fever

Diseases related to Alkhurma Hemorrhagic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)
# Related Disease Score Top Affiliating Genes
1 kyasanur forest disease 31.1 F8 CD40LG
2 acquired hemophilia 10.3 F8 F3
3 acquired hemophilia a 10.3 F8 F3
4 hemophilia a 10.3 F8 F3
5 synovial angioma 10.3 F8 F3
6 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 10.2
7 tick-borne encephalitis 10.2
8 viral hemorrhagic fever 10.2
9 prothrombin deficiency 10.2 F8 F3
10 acquired von willebrand syndrome 10.2 F8 F3
11 alpha-2-plasmin inhibitor deficiency 10.2 F8 F3
12 vitamin k deficiency bleeding 10.2 F8 F3
13 hemarthrosis 10.2 F8 F3
14 angiodysplasia 10.2 F8 F3
15 von willebrand disease, type 1 10.2 F8 F3
16 post-thrombotic syndrome 10.2 F8 F3
17 cerebral arteritis 10.2 F8 CD40LG
18 intracranial thrombosis 10.2 F8 F3
19 thrombophilia due to activated protein c resistance 10.2 F8 F3
20 factor v deficiency 10.1 F8 F3
21 factor xiii deficiency 10.1 F8 F3
22 central retinal vein occlusion 10.1 F8 F3
23 bartonellosis 10.1 TXNDC15 CD40LG
24 factor viii deficiency 10.1 F8 F3
25 mite infestation 10.1 TXNDC15 CD40LG
26 immunoglobulin g deficiency 10.1 MBL2 CD40LG
27 polycystic echinococcosis 10.1 MIF F3
28 multicentric castleman disease 10.1 F8 F3
29 paralytic poliomyelitis 10.1 NID1 CD40LG
30 lassa fever 10.1 MBTPS1 CD40LG
31 selective igg deficiency disease 10.1 MBL2 CD40LG
32 factor xi deficiency 10.0 F8 F3
33 sporotrichosis 10.0 MBL2 CD40LG
34 coccidioidomycosis 10.0 MBL2 CD40LG
35 protein s deficiency 10.0 F8 F3
36 heparin-induced thrombocytopenia 10.0 F3 CD40LG
37 myringitis bullosa hemorrhagica 10.0 PIK3C2A CD40LG
38 astrakhan spotted fever 10.0 F3 CD40LG
39 sarcocystosis 10.0 PIK3C2A CD40LG
40 tularemia 10.0 MBL2 CD40LG
41 catastrophic antiphospholipid syndrome 10.0 F3 CD40LG
42 trichinosis 10.0 PIK3C2A CD40LG
43 ornithosis 10.0 PIK3C2A CD40LG
44 goodpasture syndrome 10.0 NID1 CD40LG
45 splenic infarction 10.0 F3 CD40LG
46 splenic sequestration 10.0 F3 CD40LG
47 rocky mountain spotted fever 9.9 F3 CD40LG
48 acute hemorrhagic encephalitis 9.9 F3 CD40LG
49 hantavirus pulmonary syndrome 9.9 F3 CD40LG
50 cysticercosis 9.9 MIF CD40LG

Graphical network of the top 20 diseases related to Alkhurma Hemorrhagic Fever:



Diseases related to Alkhurma Hemorrhagic Fever

Symptoms & Phenotypes for Alkhurma Hemorrhagic Fever

MGI Mouse Phenotypes related to Alkhurma Hemorrhagic Fever:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.61 ALK CD40LG F3 F8 MBL2 MBTPS1
2 immune system MP:0005387 9.28 CD40LG F3 F8 MBL2 MBTPS1 MIF

Drugs & Therapeutics for Alkhurma Hemorrhagic Fever

Search Clinical Trials , NIH Clinical Center for Alkhurma Hemorrhagic Fever

Genetic Tests for Alkhurma Hemorrhagic Fever

Anatomical Context for Alkhurma Hemorrhagic Fever

MalaCards organs/tissues related to Alkhurma Hemorrhagic Fever:

40
Skin

Publications for Alkhurma Hemorrhagic Fever

Articles related to Alkhurma Hemorrhagic Fever:

(show all 25)
# Title Authors PMID Year
1
Development of a quantitative real-time RT-PCR assay that differentiates between Kyasanur Forest disease virus and Alkhurma hemorrhagic fever virus. 61
32009000 2020
2
In silico analysis for development of epitopes-based peptide vaccine against Alkhurma hemorrhagic fever virus. 61
31370756 2019
3
Genetic diversity of Alkhurma hemorrhagic fever virus in Western Asia. 61
30779959 2019
4
Structural disorder in the proteome and interactome of Alkhurma virus (ALKV). 61
30443749 2019
5
Defeating re-emerging Alkhurma hemorrhagic fever virus outbreak in Saudi Arabia and worldwide. 61
30260960 2018
6
Alkhurma Hemorrhagic Fever Virus RNA in Hyalomma rufipes Ticks Infesting Migratory Birds, Europe and Asia Minor. 61
29664386 2018
7
Dengue Hemorrhagic Fever Virus in Saudi Arabia: A Review. 61
29319426 2018
8
Alkhurma hemorrhagic fever virus. 61
28456648 2017
9
In vitro antiviral activity of adenosine analog NITD008 against tick-borne flaviviruses. 61
27016316 2016
10
Tick-borne viruses: a review from the perspective of therapeutic approaches. 61
24907187 2014
11
Inhibitors of the tick-borne, hemorrhagic fever-associated flaviviruses. 61
24663025 2014
12
Is the epidemiology of alkhurma hemorrhagic fever changing?: A three-year overview in Saudi Arabia. 61
24516520 2014
13
Kyasanur Forest disease virus infection in mice is associated with higher morbidity and mortality than infection with the closely related Alkhurma hemorrhagic fever virus. 61
24950196 2014
14
Neglected tropical diseases of the Middle East and North Africa: review of their prevalence, distribution, and opportunities for control. 61
22389729 2012
15
Controversy on virus designation: Alkhumra sive Alkhurma hemorrhagic fever flavivirus. 61
22433583 2012
16
Rhabdomyolysis and severe muscular weakness in a traveler diagnosed with Alkhurma hemorrhagic fever virus infection. 61
21889906 2011
17
Ancient ancestry of KFDV and AHFV revealed by complete genome analyses of viruses isolated from ticks and mammalian hosts. 61
21991403 2011
18
Alkhurma hemorrhagic fever in travelers returning from Egypt, 2010. 61
21801660 2011
19
Computer-based comparison of structural features of envelope protein of Alkhurma hemorrhagic fever virus with the homologous proteins of two closest viruses. 61
21235484 2011
20
Alkhurma hemorrhagic fever in humans, Najran, Saudi Arabia. 61
21122217 2010
21
Alkhurma hemorrhagic fever in travelers returning from Egypt, 2010. 61
21122237 2010
22
Alkhurma hemorrhagic fever virus in Ornithodoros savignyi ticks. 61
17370534 2007
23
Alkhurma hemorrhagic fever virus is an emerging tick-borne flavivirus. 61
16216331 2006
24
Low diversity of Alkhurma hemorrhagic fever virus, Saudi Arabia, 1994-1999. 61
15890119 2005
25
[Emergence of new viruses in Asia: is climate change involved?]. 61
15620053 2004

Variations for Alkhurma Hemorrhagic Fever

Expression for Alkhurma Hemorrhagic Fever

Search GEO for disease gene expression data for Alkhurma Hemorrhagic Fever.

Pathways for Alkhurma Hemorrhagic Fever

Pathways related to Alkhurma Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.96 MBL2 F8 F3
2 10.54 PIK3C2A ALK

GO Terms for Alkhurma Hemorrhagic Fever

Cellular components related to Alkhurma Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.28 TXNDC15 PTAFR PIK3C2A NID1 MIF F8
2 cell surface GO:0009986 9.26 MIF MBL2 F3 CD40LG

Biological processes related to Alkhurma Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 acute-phase response GO:0006953 8.62 MBL2 F8

Sources for Alkhurma Hemorrhagic Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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