MCID: ALK001
MIFTS: 18

Alkhurma Hemorrhagic Fever

Categories: Infectious diseases

Aliases & Classifications for Alkhurma Hemorrhagic Fever

MalaCards integrated aliases for Alkhurma Hemorrhagic Fever:

Name: Alkhurma Hemorrhagic Fever 12 3 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050308

Summaries for Alkhurma Hemorrhagic Fever

CDC : 3 Alkhurma hemorrhagic fever (AHF) is caused by Alkhurma hemorrhagic fever virus (AHFV), a tick-borne virus of the Flavivirus family. The virus was initially isolated in 1995 from a patient in Saudi Arabia. Subsequent cases of AHF have been documented in tourists in Egypt, extending the geographic range of the virus and suggesting that geographic distribution of the virus is wide and that infections due to AHFV are underreported. The persistence of the virus within tick populations, and the role of livestock in the disease transmission process, are not well understood. The AHFV virus is a variant of Kyasanur Forest Disease (KFD), a tick-borne Flavivirus found in Karnataka State and environs in India. Since the first description of AHFV, several hundred cases of AHF have been reported. Cases appear to peak in spring and summer. Further study of AHFV is needed to improve public health measures.

MalaCards based summary : Alkhurma Hemorrhagic Fever is related to kyasanur forest disease and encephalopathy, progressive, early-onset, with episodic rhabdomyolysis. An important gene associated with Alkhurma Hemorrhagic Fever is F8 (Coagulation Factor VIII), and among its related pathways/superpathways are Glioma and Crizotinib Pathway, Pharmacokinetics/Pharmacodynamics. Affiliated tissues include skin.

Disease Ontology : 12 A viral infectious disease that is a hemorrhagic fever, has material basis in Alkhurma hemorrhagic fever virus, which is transmitted by Ornithodoros savignyi tick bite, transmitted by ingestion of unpasteurized camel milk, or transmitted by entry via skin wound. The infection has symptom headache, has symptom joint pain, has symptom muscle pain, has symptom vomiting, has symptom thrombocytopenia, and has symptom hemorrhagic fever.

Related Diseases for Alkhurma Hemorrhagic Fever

Diseases related to Alkhurma Hemorrhagic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 kyasanur forest disease 30.6 F8 CD40LG
2 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 10.2
3 tick-borne encephalitis 10.2
4 viral hemorrhagic fever 10.2
5 anterior cranial fossa meningioma 10.1 POLK ANTXR2
6 cardiac tamponade 10.1 PIK3C2A F8
7 compartment syndrome 10.0 PIK3C2A F8
8 pleural lipoma 10.0 PIK3C2A ALK
9 co-trimoxazole allergy 9.9 PIK3C2A ALK
10 fournier gangrene 9.9 F8 CD40LG
11 cerebral arteritis 9.9 F8 CD40LG
12 thrombophlebitis 9.9 F8 CD40LG
13 mite infestation 9.9 TXNDC15 CD40LG
14 pediculus humanus corporis infestation 9.9 TXNDC15 CD40LG
15 pulmonary artery disease 9.9 F8 CD40LG
16 mycoplasma pneumoniae pneumonia 9.9 F8 CD40LG
17 thrombocytopenic purpura, autoimmune 9.8 F8 CD40LG
18 vein disease 9.8 F8 CD40LG
19 goodpasture syndrome 9.8 NID1 CD40LG
20 cranial nerve palsy 9.8 CD40LG ANTXR2
21 bell's palsy 9.8 CD40LG ANTXR2
22 facial paralysis 9.8 CD40LG ANTXR2
23 lassa fever 9.8 CD40LG ANTXR2
24 facial nerve disease 9.8 CD40LG ANTXR2
25 orbital plasma cell granuloma 9.7 PIK3C2A CD40LG
26 ornithosis 9.7 PIK3C2A CD40LG
27 trichinosis 9.7 PIK3C2A CD40LG
28 hemorrhagic disease 9.7 F8 CD40LG
29 hairy tongue 9.7 PIK3C2A CD40LG
30 epidemic typhus 9.7 TXNDC15 CD40LG
31 anuria 9.7 PIK3C2A CD40LG
32 erysipelas 9.7 PIK3C2A CD40LG
33 childhood type dermatomyositis 9.7 PIK3C2A CD40LG
34 acute kidney tubular necrosis 9.7 PIK3C2A CD40LG
35 aspiration pneumonia 9.7 PIK3C2A CD40LG
36 legionnaire disease 9.7 PIK3C2A CD40LG
37 pericardium disease 9.7 PIK3C2A CD40LG
38 lymphatic system cancer 9.6 CD40LG ALK
39 endocardium disease 9.6 PIK3C2A CD40LG
40 leptospirosis 9.6 PIK3C2A CD40LG
41 pericardial effusion 9.6 PIK3C2A CD40LG
42 exanthem 9.6 PIK3C2A CD40LG
43 blood coagulation disease 9.6 F8 CD40LG
44 cranial nerve disease 9.6 CD40LG ANTXR2
45 extrinsic cardiomyopathy 9.6 PIK3C2A CD40LG
46 dengue disease 9.6 PIK3C2A CD40LG
47 hair disease 9.5 CD40LG ANTXR2
48 parasitic protozoa infectious disease 9.5 TXNDC15 CD40LG
49 pulmonary embolism 9.4 F8 CD40LG
50 muscular disease 9.1 PIK3C2A CD40LG ALK

Graphical network of the top 20 diseases related to Alkhurma Hemorrhagic Fever:



Diseases related to Alkhurma Hemorrhagic Fever

Symptoms & Phenotypes for Alkhurma Hemorrhagic Fever

Drugs & Therapeutics for Alkhurma Hemorrhagic Fever

Search Clinical Trials , NIH Clinical Center for Alkhurma Hemorrhagic Fever

Genetic Tests for Alkhurma Hemorrhagic Fever

Anatomical Context for Alkhurma Hemorrhagic Fever

MalaCards organs/tissues related to Alkhurma Hemorrhagic Fever:

40
Skin

Publications for Alkhurma Hemorrhagic Fever

Articles related to Alkhurma Hemorrhagic Fever:

(show all 24)
# Title Authors PMID Year
1
In silico analysis for development of epitopes-based peptide vaccine against Alkhurma hemorrhagic fever virus. 61
31370756 2019
2
Genetic diversity of Alkhurma hemorrhagic fever virus in Western Asia. 61
30779959 2019
3
Structural disorder in the proteome and interactome of Alkhurma virus (ALKV). 61
30443749 2019
4
Defeating re-emerging Alkhurma hemorrhagic fever virus outbreak in Saudi Arabia and worldwide. 61
30260960 2018
5
Alkhurma Hemorrhagic Fever Virus RNA in Hyalomma rufipes Ticks Infesting Migratory Birds, Europe and Asia Minor. 61
29664386 2018
6
Dengue Hemorrhagic Fever Virus in Saudi Arabia: A Review. 61
29319426 2018
7
Alkhurma hemorrhagic fever virus. 61
28456648 2017
8
In vitro antiviral activity of adenosine analog NITD008 against tick-borne flaviviruses. 61
27016316 2016
9
Tick-borne viruses: a review from the perspective of therapeutic approaches. 61
24907187 2014
10
Inhibitors of the tick-borne, hemorrhagic fever-associated flaviviruses. 61
24663025 2014
11
Kyasanur Forest disease virus infection in mice is associated with higher morbidity and mortality than infection with the closely related Alkhurma hemorrhagic fever virus. 61
24950196 2014
12
Is the epidemiology of alkhurma hemorrhagic fever changing?: A three-year overview in Saudi Arabia. 61
24516520 2014
13
Neglected tropical diseases of the Middle East and North Africa: review of their prevalence, distribution, and opportunities for control. 61
22389729 2012
14
Controversy on virus designation: Alkhumra sive Alkhurma hemorrhagic fever flavivirus. 61
22433583 2012
15
Rhabdomyolysis and severe muscular weakness in a traveler diagnosed with Alkhurma hemorrhagic fever virus infection. 61
21889906 2011
16
Ancient ancestry of KFDV and AHFV revealed by complete genome analyses of viruses isolated from ticks and mammalian hosts. 61
21991403 2011
17
Alkhurma hemorrhagic fever in travelers returning from Egypt, 2010. 61
21801660 2011
18
Computer-based comparison of structural features of envelope protein of Alkhurma hemorrhagic fever virus with the homologous proteins of two closest viruses. 61
21235484 2011
19
Alkhurma hemorrhagic fever in humans, Najran, Saudi Arabia. 61
21122217 2010
20
Alkhurma hemorrhagic fever in travelers returning from Egypt, 2010. 61
21122237 2010
21
Alkhurma hemorrhagic fever virus in Ornithodoros savignyi ticks. 61
17370534 2007
22
Alkhurma hemorrhagic fever virus is an emerging tick-borne flavivirus. 61
16216331 2006
23
Low diversity of Alkhurma hemorrhagic fever virus, Saudi Arabia, 1994-1999. 61
15890119 2005
24
[Emergence of new viruses in Asia: is climate change involved?]. 61
15620053 2004

Variations for Alkhurma Hemorrhagic Fever

Expression for Alkhurma Hemorrhagic Fever

Search GEO for disease gene expression data for Alkhurma Hemorrhagic Fever.

Pathways for Alkhurma Hemorrhagic Fever

Pathways related to Alkhurma Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.73 POLK PIK3C2A ALK
2 10.2 PIK3C2A ALK

GO Terms for Alkhurma Hemorrhagic Fever

Sources for Alkhurma Hemorrhagic Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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