MCID: ALK001
MIFTS: 15

Alkhurma Hemorrhagic Fever

Categories: Infectious diseases

Aliases & Classifications for Alkhurma Hemorrhagic Fever

MalaCards integrated aliases for Alkhurma Hemorrhagic Fever:

Name: Alkhurma Hemorrhagic Fever 12 3 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050308

Summaries for Alkhurma Hemorrhagic Fever

CDC : 3 Alkhurma hemorrhagic fever (AHF) is caused by Alkhurma hemorrhagic fever virus (AHFV), a tick-borne virus of the Flavivirus family. The virus was initially isolated in 1995 from a patient in Saudi Arabia. Subsequent cases of AHF have been documented in tourists in Egypt, extending the geographic range of the virus and suggesting that geographic distribution of the virus is wide and that infections due to AHFV are underreported. The persistence of the virus within tick populations, and the role of livestock in the disease transmission process, are not well understood. The AHFV virus is a variant of Kyasanur Forest Disease (KFD), a tick-borne Flavivirus found in Karnataka State and environs in India. Since the first description of AHFV, several hundred cases of AHF have been reported. Cases appear to peak in spring and summer. Further study of AHFV is needed to improve public health measures.

MalaCards based summary : Alkhurma Hemorrhagic Fever is related to kyasanur forest disease and encephalopathy, progressive, early-onset, with episodic rhabdomyolysis. An important gene associated with Alkhurma Hemorrhagic Fever is PATZ1 (POZ/BTB And AT Hook Containing Zinc Finger 1). Related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Disease Ontology : 12 A viral infectious disease that is a hemorrhagic fever, has material basis in Alkhurma hemorrhagic fever virus, which is transmitted by Ornithodoros savignyi tick bite, transmitted by ingestion of unpasteurized camel milk, or transmitted by entry via skin wound. The infection has symptom headache, has symptom joint pain, has symptom muscle pain, has symptom vomiting, has symptom thrombocytopenia, and has symptom hemorrhagic fever.

Related Diseases for Alkhurma Hemorrhagic Fever

Diseases related to Alkhurma Hemorrhagic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 kyasanur forest disease 30.4 PATZ1 GBF1 ERVW-1
2 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 10.2
3 tick-borne encephalitis 10.2
4 viral hemorrhagic fever 10.2
5 murray valley encephalitis 9.8 XRN1 ERVW-1
6 zika fever 9.7 IFNAR1 ERVW-1

Graphical network of the top 20 diseases related to Alkhurma Hemorrhagic Fever:



Diseases related to Alkhurma Hemorrhagic Fever

Symptoms & Phenotypes for Alkhurma Hemorrhagic Fever

GenomeRNAi Phenotypes related to Alkhurma Hemorrhagic Fever according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.17 CIAO1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-112 9.17 CIAO1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-133 9.17 TOX2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.17 ERVW-1 TOX2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-143 9.17 CIAO1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-158 9.17 CIAO1

Drugs & Therapeutics for Alkhurma Hemorrhagic Fever

Search Clinical Trials , NIH Clinical Center for Alkhurma Hemorrhagic Fever

Genetic Tests for Alkhurma Hemorrhagic Fever

Anatomical Context for Alkhurma Hemorrhagic Fever

Publications for Alkhurma Hemorrhagic Fever

Articles related to Alkhurma Hemorrhagic Fever:

(show all 27)
# Title Authors PMID Year
1
Hemorrhagic fever in Saudi Arabia: challenge to public health, effective management and future considerations. 61
33402960 2020
2
Kyasanur Forest Disease and Alkhurma Hemorrhagic Fever Virus-Two Neglected Zoonotic Pathogens. 61
32932653 2020
3
In silico analysis for development of epitopes-based peptide vaccine against Alkhurma hemorrhagic fever virus. 61
31370756 2020
4
Development of a quantitative real-time RT-PCR assay that differentiates between Kyasanur Forest disease virus and Alkhurma hemorrhagic fever virus. 61
32009000 2020
5
Genetic diversity of Alkhurma hemorrhagic fever virus in Western Asia. 61
30779959 2019
6
Structural disorder in the proteome and interactome of Alkhurma virus (ALKV). 61
30443749 2019
7
Defeating re-emerging Alkhurma hemorrhagic fever virus outbreak in Saudi Arabia and worldwide. 61
30260960 2018
8
Alkhurma Hemorrhagic Fever Virus RNA in Hyalomma rufipes Ticks Infesting Migratory Birds, Europe and Asia Minor. 61
29664386 2018
9
Dengue Hemorrhagic Fever Virus in Saudi Arabia: A Review. 61
29319426 2018
10
Alkhurma hemorrhagic fever virus. 61
28456648 2017
11
In vitro antiviral activity of adenosine analog NITD008 against tick-borne flaviviruses. 61
27016316 2016
12
Tick-borne viruses: a review from the perspective of therapeutic approaches. 61
24907187 2014
13
Inhibitors of the tick-borne, hemorrhagic fever-associated flaviviruses. 61
24663025 2014
14
Is the epidemiology of alkhurma hemorrhagic fever changing?: A three-year overview in Saudi Arabia. 61
24516520 2014
15
Kyasanur Forest disease virus infection in mice is associated with higher morbidity and mortality than infection with the closely related Alkhurma hemorrhagic fever virus. 61
24950196 2014
16
Neglected tropical diseases of the Middle East and North Africa: review of their prevalence, distribution, and opportunities for control. 61
22389729 2012
17
Controversy on virus designation: Alkhumra sive Alkhurma hemorrhagic fever flavivirus. 61
22433583 2012
18
Rhabdomyolysis and severe muscular weakness in a traveler diagnosed with Alkhurma hemorrhagic fever virus infection. 61
21889906 2011
19
Ancient ancestry of KFDV and AHFV revealed by complete genome analyses of viruses isolated from ticks and mammalian hosts. 61
21991403 2011
20
Alkhurma hemorrhagic fever in travelers returning from Egypt, 2010. 61
21801660 2011
21
Computer-based comparison of structural features of envelope protein of Alkhurma hemorrhagic fever virus with the homologous proteins of two closest viruses. 61
21235484 2011
22
Alkhurma hemorrhagic fever in humans, Najran, Saudi Arabia. 61
21122217 2010
23
Alkhurma hemorrhagic fever in travelers returning from Egypt, 2010. 61
21122237 2010
24
Alkhurma hemorrhagic fever virus in Ornithodoros savignyi ticks. 61
17370534 2007
25
Alkhurma hemorrhagic fever virus is an emerging tick-borne flavivirus. 61
16216331 2006
26
Low diversity of Alkhurma hemorrhagic fever virus, Saudi Arabia, 1994-1999. 61
15890119 2005
27
[Emergence of new viruses in Asia: is climate change involved?]. 61
15620053 2004

Variations for Alkhurma Hemorrhagic Fever

Expression for Alkhurma Hemorrhagic Fever

Search GEO for disease gene expression data for Alkhurma Hemorrhagic Fever.

Pathways for Alkhurma Hemorrhagic Fever

GO Terms for Alkhurma Hemorrhagic Fever

Biological processes related to Alkhurma Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to virus GO:0098586 8.62 IL12A GBF1

Sources for Alkhurma Hemorrhagic Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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