Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: ALL012
MIFTS: 25

Allergic Angiitis

Categories: Immune diseases, Rare diseases
Tissues Related diseases Publications Drugs
Sources

Aliases & Classifications for Allergic Angiitis

About this section

MalaCards integrated aliases for Allergic Angiitis:

Name: Allergic Angiitis 53
Churg-Strauss Syndrome 72

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Immune diseases
See all MalaCards categories (disease lists)


External Ids:

UMLS 72 C0008728
Sources

Summaries for Allergic Angiitis

About this section
MalaCards based summary : Allergic Angiitis, also known as churg-strauss syndrome, is related to eosinophilic granulomatosis with polyangiitis and vasculitis. The drugs Cyclophosphamide and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, lung and heart.

Wikipedia : 75 Eosinophilic granulomatosis with polyangiitis (EGPA), also known as allergic granulomatosis, is an... more...

Sources

Related Diseases for Allergic Angiitis

About this section

Diseases related to Allergic Angiitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
# Related Disease Score Top Affiliating Genes
1 eosinophilic granulomatosis with polyangiitis 12.0
2 vasculitis 10.3
3 hypereosinophilic syndrome 10.3
4 churg-strauss syndrome 10.2
5 purpura 10.2
6 mononeuritis multiplex 10.1
7 kaposi sarcoma 9.9
8 lymphoma 9.9
9 henoch-schoenlein purpura 9.9
10 sarcoma 9.9
11 bronchopneumonia 9.9
12 dermatitis 9.9
13 spindle cell sarcoma 9.9
14 myocarditis 9.9
15 lupus erythematosus 9.9
16 polyarteritis nodosa 9.9
17 lymphosarcoma 9.9

Graphical network of the top 20 diseases related to Allergic Angiitis:



Diseases related to Allergic Angiitis
Sources

Symptoms & Phenotypes for Allergic Angiitis

About this section
Sources

Drugs & Therapeutics for Allergic Angiitis

About this section

Drugs for Allergic Angiitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 77)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 4 50-18-0, 6055-19-2 2907
2
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
3
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
4
leucovorin Approved Phase 4 58-05-9 143 6006
5
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
6
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
7
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
8
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
9
Mycophenolic acid Approved Phase 4 24280-93-1 446541
10
rituximab Approved Phase 4 174722-31-7 10201696
11
Azathioprine Approved Phase 4 446-86-6 2265
12
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
13
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
14 Hormone Antagonists Phase 4
15 Anti-Inflammatory Agents Phase 4
16 Hormones Phase 4
17 Antineoplastic Agents, Hormonal Phase 4
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
19 Gastrointestinal Agents Phase 4
20 Dermatologic Agents Phase 4
21 Alkylating Agents Phase 4
22 Antineoplastic Agents, Alkylating Phase 4
23 Folic Acid Antagonists Phase 4
24 Vitamin B9 Phase 4
25 Nucleic Acid Synthesis Inhibitors Phase 4
26 Vitamin B Complex Phase 4
27 Folate Phase 4
28 Antiemetics Phase 4
29 Neuroprotective Agents Phase 4
30 Methylprednisolone Acetate Phase 4
31 Protective Agents Phase 4
32 Prednisolone acetate Phase 4
33 Autonomic Agents Phase 4
34 Anti-Infective Agents Phase 4
35 Anti-Bacterial Agents Phase 4
36 Antitubercular Agents Phase 4
37 Antibiotics, Antitubercular Phase 4
38 glucocorticoids Phase 4
39 Antineoplastic Agents, Immunological Phase 4
40 Immunologic Factors Phase 4
41 Antirheumatic Agents Phase 4
42 Immunosuppressive Agents Phase 4
43 Antimetabolites Phase 4
44 Antimetabolites, Antineoplastic Phase 4
45 Antibodies Phase 3
46 Immunoglobulins Phase 3
47 Immunoglobulin G Phase 3
48 Rho(D) Immune Globulin Phase 3
49 gamma-Globulins Phase 3
50 Immunoglobulins, Intravenous Phase 3

Interventional clinical trials:

(show all 40)
# Name Status NCT ID Phase Drugs
1 CHUSPAN SCS BP Treatment of Churg–Strauss Syndrome Without Poor-Prognosis Factors: a Prospective Randomized Study in 72 Patients. Unknown status NCT00399399 Phase 4 azathioprine;cyclophosphamide
2 Treatment of Necrotizing Vasculitides for Patients Older Than 65 Years Comparison of Two Strategies Combining Steroids With or Without Immunosuppressants Completed NCT00307671 Phase 4 prednisone, methylprednisolone,cyclophosphamides;Cyclophosphamide, Azathioprine,prednisone,methylprednisolone;Mycophenolate mofetil,methotrexate
3 MAINtenance of Remission With RITuximab Versus Azathioprine for Patients With Newly-diagnosed or Relapsing Eosinophilic Granulomatosis With Polyangiitis. A Prospective, Randomized, Controlled, Double-blind Study: the MAINRITSEG Trial Recruiting NCT03164473 Phase 4 Rituximab;Azathioprine;Placebo-rituximab;Placebo-azathioprine
4 A Double-blind, Randomised, Placebo-controlled Study to Investigate the Efficacy and Safety of Mepolizumab in the Treatment of Eosinophilic Granulomatosis With Polyangiitis in Subjects Receiving Standard of Care Therapy Completed NCT02020889 Phase 3 Placebo
5 Evaluation of a New Treatment Strategy for Patients With Microscopic Polyangiitis, Polyarteritis Nodosa or Eosinophilic Granulomatosis With Polyangiitis (Churg Strauss Syndrome) Without Poor Prognosis Factors Completed NCT00647166 Phase 3 corticosteroid and azathioprine;corticosteroid and placebo
6 Evaluation of Rituximab-based Regimen Compared to Conventional Therapeutic Strategy For Remission Induction In Patients With Newly-Diagnosed or Relapsing Eosinophilic Granulomatosis With Polyangiitis. Prospective, Randomized, Controlled, Double-blind Study Recruiting NCT02807103 Phase 3 Rituximab;Placebo-rituximab;Cyclophosphamide;Placebo-cyclophosphamide
7 Mepolizumab Long-term Access Programme for Subjects Who Participated in Study MEA115921 (Placebo-controlled Study of Mepolizumab in the Treatment of Eosinophilic Granulomatosis With Polyangiitis in Subjects Receiving Standard-of-care Therapy) Active, not recruiting NCT03298061 Phase 3 Mepolizumab;Prednisolone
8 Intravenous Immunoglobulin After Relapse in Vasculitis (Microscopic Polyangiitis, Wegener’s Granulomatosis and SHURG-STRAUSS Syndrome) During and After Corticosteroids and Immunosuppressant Therapies a Multicenter Prospective Trial Terminated NCT00307658 Phase 3 Intravenous immunoglobulins (human immunoglobulins G)
9 Cyclophosphamide Versus Methotrexate for Remission Maintenance in Systemic Necrotizing Vasculitides. A Randomized Controlled Trial. Unknown status NCT00751517 Phase 2 Methotrexate;Cyclophosphamide
10 The Efficacy and Safety of Benralizumab In the Treatment of Eosinophilic Grandulomatosis With Polyangiitis (EGPA) Study: BITE Unknown status NCT03010436 Phase 2 Benralizumab
11 A Phase II, Single Center Open Label, Prospective Trial to Evaluate the Efficacy and Safety of Mepolizumab for Patients With Refractory or Relapsing Churg Strauss Syndrome Completed NCT00716651 Phase 2 mepolizumab
12 Mepolizumab As a Steroid Sparing Treatment Option in the Churg Strauss Syndrome Completed NCT00527566 Phase 1, Phase 2
13 A Phase I/II Study of the Effect of Intravenous Anti-IL-5 (Mepolizumab) SB 240563 on the Outcome and Management of Hypereosinophilic Syndromes Completed NCT00266565 Phase 1, Phase 2 Mepolizumab
14 Low Dose Naltrexone to Improve Physical Health in Patients With Vasculitis Recruiting NCT03482479 Phase 2 Naltrexone Hydrochloride
15 Open-Label, to Evaluate the Efficacy and Safety of Reslizumab in the Treatment of Eosinophilic Granulomatosis With Polyangiitis (EGPA) Study: RITE Study Recruiting NCT02947945 Phase 2 Reslizumab
16 A Pilot Study on the Use of Rituximab in the Treatment of Churg- Strauss Syndrome With Renal Involvement Terminated NCT00424749 Phase 2 Rituximab;Prednisone
17 A Pilot Study Examining the Effect of Abatacept in ANCA Associated Vasculitis Terminated NCT00482066 Phase 2 Abatacept (Orencia)
18 High Dose Immune Suppression With Hematopoietic Stem Cell Support in Refractory Vasculitis, Necrotizing Vasculitis, Neurovascular Behcet's Disease, and Sjogren's Syndrome Terminated NCT00278512 Phase 1 Cyclophosphamide;ATG (rabbit);G-CSF;Campath-1h;Fludarabine;Tacrolimus;Mesna
19 A Qualitative Study Using Interviews With Patients Who Have Anti-neutrophil Cytoplasm Antibody (ANCA) Associated Vasculitis, to Develop a Patient Reported Outcome (PRO) Measure Unknown status NCT01729624
20 Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases Unknown status NCT00006055 anti-thymocyte globulin;cyclophosphamide;cyclosporine;filgrastim;methylprednisolone;prednisone
21 ACR/EULAR Endorsed Study to Develop New Diagnostic and Classification Criteria for Primary Systemic Vasculitis Unknown status NCT01066208
22 Infliximab Versus Rituximab in Systemic Necrotizing Vasculitides With Positive ANCA After Relapse or Resistant Immunosuppressant Therapies Completed NCT00307593 Infliximab;Rituximab
23 Reproductive Health in Men and Women With Vasculitis Completed NCT02176070
24 Educational Needs of Patients With Systemic Vasculitis- an International Survey Completed NCT02190929
25 Illness Perception, Fatigue, and Function in Systemic Vasculitis (The VCRC Vasculitis Perception (VIP) Study) Completed NCT02190916
26 The Journey of Patients With Vasculitis From First Symptom to Diagnosis Completed NCT03410290
27 The Serum Eosinophil Cationic Protein Levels in Behçet's Disease and Its Relation to the Clinical Activity Completed NCT01584778
28 The ANCA Vasculitis Questionnaire (AAV-PRO©) Completed NCT02507024
29 Clinical Transcriptomics in Systemic Vasculitis (CUTIS) Recruiting NCT03004326
30 Eosinophilic Granulomatosis With Polyangiitis Cohort Recruiting NCT03036670
31 VCRC Tissue Biorepository Collection Protocol Recruiting NCT02967068
32 The Vasculitis Pregnancy Registry (V-PREG) Recruiting NCT02593565
33 Clinical and Echocardiographic Evaluation of Patients With Granulomatosis With Polyangiitis Recruiting NCT03782870
34 Longitudinal Protocol for Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss) Recruiting NCT00315380
35 VCRC Genetic Repository One-Time DNA Protocol Recruiting NCT01241305
36 Chronic Childhood Vasculitis: Characterizing the Individual Rare Diseases to Improve Patient Outcomes Recruiting NCT02006134
37 NUCALA ® Subcutaneous Injection Special Drug Use Investigation (EGPA, Long-term） Active, not recruiting NCT03557060 Nucala
38 VCRC Validation of Patient-Reported Diagnostic Data Enrolling by invitation NCT02190942
39 A Pilot Study of Immuno-ablation With Chemoimmunoradiation Followed by Autologous Hematopoietic Progenitor Cell (HPC) Transplant for Adult Subjects With Churg-Strauss Syndrome Terminated NCT02728271 Early Phase 1
40 Defining Immune Tolerance in ANCA-associated Vasculitis (AAV) Terminated NCT01934504

Search NIH Clinical Center for Allergic Angiitis

Sources

Genetic Tests for Allergic Angiitis

About this section
Sources

Anatomical Context for Allergic Angiitis

About this section

MalaCards organs/tissues related to Allergic Angiitis:

41
Neutrophil, Lung, Heart, Testes, Skin, T Cells, Colon
Sources

Publications for Allergic Angiitis

About this section

Articles related to Allergic Angiitis:

(show top 50) (show all 1970)
# Title Authors PMID Year
1
Pruritic skin involvement of necrotizing sarcoid granulomatosis: a case report. 38
31407372 2019
2
Eosinophilic Granulomatosis with Polyangiitis: Experiences in Korean Patients. 38
31347324 2019
3
Co-occurrence of PLA2R-positive membranous nephropathy without crescents, and PR3-positive eosinophilic granulomatosis with polyangiitis
. 38
31347497 2019
4
Cutaneous Vasculitis as Early Presentation of Eosinophilic Granulomatosis with Polyangiitis without Systemic Symptoms. 38
31360325 2019
5
Update on eosinophilic granulomatosis with polyangiitis. 38
31266709 2019
6
Eosinophilic granulomatosis with polyangiitis in a Nigerian woman. 38
31217209 2019
7
Causes of eosinophilic ascites - A systematic review. 38
30864403 2019
8
[Current treatment of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)]. 38
30627842 2019
9
Targeted immunotherapy strategies in ANCA-associated vasculitis. 38
30201478 2019
10
Anti-Neutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis Causes Aortic Valve Degeneration and Severe Aortic Regurgitation. 38
30930460 2019
11
[Unexpected death due to eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)]. 38
30720008 2019
12
Eosinophilic granulomatosis with polyangiitis in a continuous flow left ventricular assist device patient: a case report and review of literature. 38
30684748 2019
13
Massive Myocardial Necrosis due to Churg-Strauss Syndrome. 38
29884587 2019
14
Ultrasound diagnosis of typhlitis. 38
30367357 2019
15
Immunoglobulin G4-Related Disease Presenting with Clinical Similarity to Churg-Strauss Syndrome. 38
30772966 2019
16
Ophthalmic Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss Syndrome): A Systematic Review of the Literature. 38
30134390 2019
17
Necrotizing Sarcoid Granulomatosis with Pneumothorax. 38
31275399 2019
18
Eosinophilic Granulomatosis with Polyangiitis Manifesting as Recurrent Nasal Polyps and Hemorrhagic Necrotic Bullae: A Rare Disease Successfully Treated with Azathioprine. 38
31043937 2019
19
Churg-Strauss Syndrome Presenting as Acute Necrotizing Eosinophilic Myocarditis: Concise Review of the Literature. 38
30179138 2019
20
Rare Manifestations of Churg-Strauss Syndrome with Mediastinal and Hilar Lymphadenopathies: Report of an Autopsy Case. 38
29249116 2019
21
Churg-strauss syndrome: clinical case and its feautures. 38
31055564 2019
22
Differential Diagnosis of Churg-Strauss Syndrome with Tingling Sensation and Weakness of the Lower Extremities. 38
30719419 2018
23
Histopathological Findings and Increased D-Dimer Are Predictive Factors of Systemic Thromboses in Eosinophilic Granulomatosis With Polyangiitis. 38
29979194 2018
24
[Vasculitides and eosinophilic pulmonary diseases]. 38
30367242 2018
25
Perinuclear antineutrophil cytoplasmic antibody-associated pulmonary vasculitis masquerading as lung metastasis. 38
31397366 2018
26
[Hypokinetic cardiac arrest and hypereosinophilia: a case of Kounis or Churg-Strauss syndrome?] 38
30425395 2018
27
Coronary artery vasospasm in a patient with Churg-Strauss syndrome. 38
30366890 2018
28
Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) masquerading as acute ST-elevation myocardial infarction with complete resolution after immunosuppressive therapy: a case report. 38
31020153 2018
29
Successful treatment outcomes in pregnant patients with ANCA-associated vasculitides: A systematic review of literature. 38
30345645 2018
30
[Vasculitides and eosinophilic pulmonary diseases]. 38
30140942 2018
31
Eosinophilic Granulomatosis with Polyangiitis: Clinical Pathology Conference and Review. 38
30197069 2018
32
Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss). 38
30404114 2018
33
Diffuse Alveolar Hemorrhage and Pulmonary Vasculitides: Histopathologic Findings. 38
30404110 2018
34
Pulmonary Renal Syndrome: Experience from Tertiary Centre in Mumbai. 38
31325253 2018
35
Treatment of Eosinophilic Granulomatosis with Polyangiitis: A Review. 38
29766394 2018
36
Recurrence of eosinophilic granulomatosis with polyangitis after orthotopic heart transplant. 38
29392845 2018
37
[Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)]. 38
28983650 2018
38
Eosinophilic Granulomatosis with Polyangiitis Manifested by Cholecystitis and Mononeuritis Multiplex: A Case Report. 38
29892153 2018
39
Churg-Strauss Syndrome or Eosinophilic Granulomatosis with Polyangiitis: Exuberant Classic Clinical Picture of a Rare Disease. 38
30057533 2018
40
Churg-Strauss syndrome with cardiac involvement: case illustration and contribution of CMR in the diagnosis and clinical follow-up. 38
29459042 2018
41
Anaesthetic management and the role of sugammadex in a patient with Churg-Strauss syndrome. 38
29910505 2018
42
[Bilateral multifocal choroidal ischemia complicating Churg-Strauss syndrome]. 38
29773312 2018
43
Eosinophilic granulomatosis with polyangiitis without respiratory symptoms or asthma in an adolescent: case report and literature review. 38
29189887 2018
44
[Clinical Analysis of 40 Patients with Eosinophilic Lung Diseases in Peking Union Medical College Hospital]. 38
29724306 2018
45
Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Syndrome) Complicated by Perforation of the Small Intestine and Cholecystitis. 38
29269641 2018
46
A 92-Year-Old Male with Eosinophilic Asthma Presenting with Recurrent Palpable Purpuric Plaques. 38
29719830 2018
47
Paediatric anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis: an update on renal management. 38
28062909 2018
48
Focus on the Involvement of the Nose and Paranasal Sinuses in Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Syndrome): Nasal Cytology Reveals Infiltration of Eosinophils as a Very Common Feature. 38
29393242 2018
49
Yield of Screening Tests for Systemic Vasculitis in Young Adults with Ischemic Stroke. 38
30716738 2018
50
Cardiogenic Shock: An Unusual Initial Presentation of Churg-Strauss Syndrome. 38
29808153 2018
Sources

Variations for Allergic Angiitis

About this section
Sources

Expression for Allergic Angiitis

About this section
Search GEO for disease gene expression data for Allergic Angiitis.
Sources

Pathways for Allergic Angiitis

About this section
Sources

GO Terms for Allergic Angiitis

About this section
Sources

Sources for Allergic Angiitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....