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MCID: ALL012
MIFTS: 26

Allergic Angiitis

Categories: Immune diseases, Rare diseases
Tissues Related diseases Publications Drugs
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Aliases & Classifications for Allergic Angiitis

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MalaCards integrated aliases for Allergic Angiitis:

Name: Allergic Angiitis 54
Churg-Strauss Syndrome 74

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Immune diseases
See all MalaCards categories (disease lists)


External Ids:

UMLS 74 C0008728
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Summaries for Allergic Angiitis

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MalaCards based summary : Allergic Angiitis, also known as churg-strauss syndrome, is related to eosinophilic granulomatosis with polyangiitis and purpura. The drugs Cyclophosphamide and Azathioprine have been mentioned in the context of this disorder. Affiliated tissues include colon, heart and neutrophil.

Wikipedia : 77 Eosinophilic granulomatosis with polyangiitis (EGPA), also known as allergic granulomatosis, is an... more...

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Related Diseases for Allergic Angiitis

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Diseases related to Allergic Angiitis via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 eosinophilic granulomatosis with polyangiitis 11.8
2 purpura 10.1
3 sarcoma 9.9
4 churg-strauss syndrome 9.9
5 lupus erythematosus 9.9
6 polyarteritis nodosa 9.9

Graphical network of the top 20 diseases related to Allergic Angiitis:



Diseases related to Allergic Angiitis
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Symptoms & Phenotypes for Allergic Angiitis

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Drugs & Therapeutics for Allergic Angiitis

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Drugs for Allergic Angiitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 77)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-18-0, 6055-19-2 2907
2
Azathioprine Approved Phase 4,Phase 3,Early Phase 1 446-86-6 2265
3
leucovorin Approved Phase 4,Phase 2 58-05-9 143 6006
4
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 53-03-2 5865
5
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Not Applicable 302-25-0
6
Methotrexate Approved Phase 4,Phase 2 1959-05-2, 59-05-2 126941
7
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Not Applicable 2921-57-5
8
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Not Applicable 50-24-8 5755
9
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Not Applicable 83-43-2 6741
10
Mycophenolic acid Approved Phase 4 24280-93-1 446541
11
rituximab Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 174722-31-7 10201696
12
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 59-30-3 6037
13
Prednisolone hemisuccinate Experimental Phase 4,Phase 3,Not Applicable 2920-86-7
14 Antimetabolites Phase 4,Phase 3,Phase 2
15 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
16 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2
17 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
18 Antineoplastic Agents, Alkylating Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
19 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
20 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
21 Protective Agents Phase 4,Phase 3,Phase 1,Not Applicable
22 glucocorticoids Phase 4,Phase 3,Phase 2,Not Applicable
23 Autonomic Agents Phase 4,Phase 3,Not Applicable
24 Folate Phase 4,Phase 2
25 Vitamin B Complex Phase 4,Phase 2
26 Folic Acid Antagonists Phase 4,Phase 2
27 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
28 Prednisolone acetate Phase 4,Phase 3,Not Applicable
29 Hormones Phase 4,Phase 3,Phase 2,Not Applicable
30 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Not Applicable
31 Vitamin B9 Phase 4,Phase 2
32 Dermatologic Agents Phase 4,Phase 2,Not Applicable
33 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
34 Gastrointestinal Agents Phase 4,Phase 3,Not Applicable
35 Methylprednisolone Acetate Phase 4,Phase 3,Not Applicable
36 Anti-Infective Agents Phase 4,Not Applicable
37 Antiemetics Phase 4,Phase 3,Not Applicable
38 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Not Applicable
39 Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
40 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2
41 Neuroprotective Agents Phase 4,Phase 3,Not Applicable
42 Antibiotics, Antitubercular Phase 4
43 Antitubercular Agents Phase 4
44 Anti-Bacterial Agents Phase 4
45 Antineoplastic Agents, Immunological Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Immunoglobulins Phase 3,Phase 2,Phase 1,Not Applicable
47 Antibodies Phase 3,Phase 2,Phase 1,Not Applicable
48 Pharmaceutical Solutions Phase 3
49 Immunoglobulins, Intravenous Phase 3
50 Rho(D) Immune Globulin Phase 3

Interventional clinical trials:

(show all 44)
# Name Status NCT ID Phase Drugs
1 CHUSPAN SCS BP Treatment of Churg–Strauss Syndrome Without Poor-Prognosis Factors Unknown status NCT00399399 Phase 4 azathioprine;cyclophosphamide
2 Treatment of Necrotizing Vasculitides for Patients Older Than 65 Years Completed NCT00307671 Phase 4 prednisone, methylprednisolone,cyclophosphamides;Cyclophosphamide, Azathioprine,prednisone,methylprednisolone;Mycophenolate mofetil,methotrexate
3 Maintenance of Remission With Rituximab Versus Azathioprine for Newly-diagnosed or Relapsing Eosinophilic Granulomatosis With Polyangiitis. Recruiting NCT03164473 Phase 4 Rituximab;Azathioprine;Placebo-rituximab;Placebo-azathioprine
4 A Study to Investigate Mepolizumab in the Treatment of Eosinophilic Granulomatosis With Polyangiitis Completed NCT02020889 Phase 3 Placebo
5 Association Corticosteroid/Azathioprine in Microscopic Polyangiitis/ Polyarteritis Nodosa or Eosinophilic Granulomatosis With Polyangiitis (Churg Strauss Syndrome) Completed NCT00647166 Phase 3 corticosteroid and azathioprine;corticosteroid and placebo
6 Rituximab in Eosinophilic Granulomatosis With Polyangiitis Recruiting NCT02807103 Phase 3 Rituximab;Placebo-rituximab;Cyclophosphamide;Placebo-cyclophosphamide
7 Long-term Access Program (LAP) of Mepolizumab for Subjects Who Participated in Study MEA115921 Active, not recruiting NCT03298061 Phase 3 Mepolizumab;Prednisolone
8 Efficacy and Safety Study of Mepolizumab in Subjects With Severe Hypereosinophilic Syndrome (HES) Active, not recruiting NCT02836496 Phase 3 Mepolizumab 300 mg;Placebo matching mepolizumab;Active OCS capsules (5 mg prednisolone or prednisone);Placebo matching OCS capsules
9 Intravenous Immunoglobulin After Relapse in Vasculitis Terminated NCT00307658 Phase 3 Intravenous immunoglobulins (human immunoglobulins G)
10 Cyclophosphamide Versus Methotrexate for Remission Maintenance in Systemic Necrotizing Vasculitides Unknown status NCT00751517 Phase 2 Methotrexate;Cyclophosphamide
11 Benralizumab in the Treatment of Eosinophilic Granulomatosis With Polyangiitis (EGPA) Study Unknown status NCT03010436 Phase 2 Benralizumab
12 Mepolizumab As a Steroid-sparing Treatment Option in the Churg Strauss Syndrome Completed NCT00527566 Phase 1, Phase 2
13 Safety and Efficacy Study of Mepolizumab in Churg Strauss Syndrome Completed NCT00716651 Phase 2 mepolizumab
14 Anti-Interleukin-5 (IL-5) Study for Hypereosinophilic Syndrome Completed NCT00266565 Phase 1, Phase 2 Mepolizumab
15 Steroids and Methotrexate to Treat Systemic Vasculitis Completed NCT00001256 Phase 2 prednisone and methotrexate
16 Reslizumab in the Treatment of Eosinophilic Granulomatosis With Polyangiitis (EGPA) Study Recruiting NCT02947945 Phase 2 Reslizumab
17 Low Dose Naltrexone to Improve Physical Health in Patients With Vasculitis Recruiting NCT03482479 Phase 2 Naltrexone Hydrochloride
18 Rituxan in Churg Strauss Syndrome With Renal Involvement Terminated NCT00424749 Phase 2 Rituximab;Prednisone
19 Abatacept in ANCA Associated Vasculitis Terminated NCT00482066 Phase 2 Abatacept (Orencia)
20 Hematopoietic Stem Cell Support in Vasculitis Terminated NCT00278512 Phase 1 Cyclophosphamide;ATG (rabbit);G-CSF;Campath-1h;Fludarabine;Tacrolimus;Mesna
21 PRO Development for ANCA Associated Vasculitis Unknown status NCT01729624
22 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) Diagnostic and Classification Criteria for Primary Systemic Vasculitis Unknown status NCT01066208
23 Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases Unknown status NCT00006055 Not Applicable anti-thymocyte globulin;cyclophosphamide;cyclosporine;filgrastim;methylprednisolone;prednisone
24 RATTRAP: Infliximab Versus Rituximab in Systemic Necrotizing Vasculitides Completed NCT00307593 Not Applicable Infliximab;Rituximab
25 Educational Needs of Patients With Systemic Vasculitis Completed NCT02190929
26 The ANCA Vasculitis Questionnaire (AAV-PRO©) Completed NCT02507024
27 Vasculitis Illness Perception (VIP) Study Completed NCT02190916
28 Reproductive Health in Men and Women With Vasculitis Completed NCT02176070
29 Steroid-Induced Osteoporosis in the Pediatric Population - Canadian Incidence Study Completed NCT01663129
30 Journey of Patients With Vasculitis From First Symptom to Diagnosis Completed NCT03410290
31 Survey of Patients With Idiopathic Orbital Inflammation Syndrome Completed NCT01443000
32 Eosinophilic Granulomatosis With Polyangiitis Cohort Recruiting NCT03036670
33 Determining Disease Activity Biomarkers in Individuals With Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss) Recruiting NCT00315380
34 Pediatric Vasculitis Initiative Recruiting NCT02006134
35 VCRC Tissue Repository Recruiting NCT02967068
36 Vasculitis Pregnancy Registry Recruiting NCT02593565
37 One-Time DNA Study for Vasculitis Recruiting NCT01241305
38 Clinical Transcriptomics in Systemic Vasculitis (CUTIS) Recruiting NCT03004326
39 Soluble CD95 Ligand Role in the Pathophysiology of Antineutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis Recruiting NCT03698071 Not Applicable
40 Observational Study of Characteristics, Treatment and Outcomes With Severe Asthma in the United States (CHRONICLE) Recruiting NCT03373045
41 NUCALA® Special Drug Use Investigation (EGPA, Long-term) Active, not recruiting NCT03557060 Nucala
42 Neutrophils as Prognostic Factors in Granulomatosis With Polyangiitis (Formerly Named Wegener's Granulomatosis) Active, not recruiting NCT01862068
43 VCRC Patient Contact Registry Patient-Reported Data Validation Study Enrolling by invitation NCT02190942
44 Immuno-ablation With Chemoimmunoradiation and Autologous Stem Cell Transplant for Churg-Strauss Syndrome Terminated NCT02728271 Early Phase 1

Search NIH Clinical Center for Allergic Angiitis

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Genetic Tests for Allergic Angiitis

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Anatomical Context for Allergic Angiitis

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MalaCards organs/tissues related to Allergic Angiitis:

42
Colon, Heart, Neutrophil, Lung, Liver, T Cells, Small Intestine
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Publications for Allergic Angiitis

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Articles related to Allergic Angiitis:

(show top 50) (show all 958)
# Title Authors Year
1
Massive Myocardial Necrosis due to Churg-Strauss Syndrome. ( 29884587 )
2019
2
Ophthalmic Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss Syndrome): A Systematic Review of the Literature. ( 30134390 )
2019
3
Churg-Strauss Syndrome Presenting as Acute Necrotizing Eosinophilic Myocarditis: Concise Review of the Literature. ( 30179138 )
2019
4
Immunoglobulin G4-Related Disease Presenting with Clinical Similarity to Churg-Strauss Syndrome. ( 30772966 )
2019
5
Churg-strauss syndrome: clinical case and its feautures. ( 31055564 )
2019
6
Cardiogenic Shock: An Unusual Initial Presentation of Churg-Strauss Syndrome. ( 29808153 )
2018
7
Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Syndrome) Complicated by Perforation of the Small Intestine and Cholecystitis. ( 29269641 )
2018
8
Focus on the Involvement of the Nose and Paranasal Sinuses in Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Syndrome): Nasal Cytology Reveals Infiltration of Eosinophils as a Very Common Feature. ( 29393242 )
2018
9
Churg-Strauss syndrome with cardiac involvement: case illustration and contribution of CMR in the diagnosis and clinical follow-up. ( 29459042 )
2018
10
Anaesthetic management and the role of sugammadex in a patient with Churg-Strauss syndrome. ( 29910505 )
2018
11
Churg-Strauss Syndrome or Eosinophilic Granulomatosis with Polyangiitis: Exuberant Classic Clinical Picture of a Rare Disease. ( 30057533 )
2018
12
Coronary artery vasospasm in a patient withChurg-Strauss syndrome. ( 30366890 )
2018
13
Differential Diagnosis of Churg-Strauss Syndrome with Tingling Sensation and Weakness of the Lower Extremities. ( 30719419 )
2018
14
Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) masquerading as acute ST-elevation myocardial infarction with complete resolution after immunosuppressive therapy: a case report. ( 31020153 )
2018
15
Eosinophilic Annular Erythema Associated with Churg-Strauss Syndrome. ( 29200781 )
2017
16
Multiple Thromboembolic Cerebral Infarctions from the Aorta in a Patient with Churg-Strauss Syndrome. ( 27993446 )
2017
17
Polyneuropathy with demyelinating changes in Churg-Strauss syndrome: an unusual association. ( 28025723 )
2017
18
ANCA-Negative Churg-Strauss Syndrome Presenting as Acute Multiple Cerebral Infarcts: A Case Report. ( 28065613 )
2017
19
Clinical Characteristics and Treatment Response of Peripheral Neuropathy in the Presence of Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Syndrome): Experience at a Single Tertiary Center. ( 28079316 )
2017
20
Low Median Nerve Palsy as Initial Manifestation of Churg-Strauss Syndrome. ( 28089164 )
2017
21
Omalizumab-associated eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). ( 28094120 )
2017
22
Eye problems in a woman with Churg-Strauss syndrome. ( 28098669 )
2017
23
Heart involvement in Churg-Strauss syndrome. ( 28205199 )
2017
24
Hospital Morbidity Database for Epidemiological Studies on Churg-Strauss Syndrome. ( 28255916 )
2017
25
Two different causes in a patient with distal symmetric axonal polyneuropathy: Churg-Strauss syndrome and multiple myeloma, coincidental or associated with each other? ( 28332041 )
2017
26
Eosinophilic granulomatosis with polyangiitis (formerly known as Churg-Strauss syndrome) as a differential diagnosis of hypereosinophilic syndromes. ( 28337408 )
2017
27
A Case of Churg-Strauss Syndrome (Eosinophilic Granulomatosis With Polyangiitis) of the Urinary Bladder. ( 28477943 )
2017
28
Diagnosis of Churg-Strauss Syndrome Presented With Neuroendocrine Carcinoma: A Case Report. ( 28758089 )
2017
29
Sequential rituximab and omalizumab for the treatment of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). ( 28762062 )
2017
30
Eosinophilic myocarditis as a first presentation of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). ( 29170172 )
2017
31
Churg-strauss syndrome: a case report. ( 29203755 )
2017
32
Rare Manifestation of Churg-Strauss Syndrome with Mediastinal Lymphadenopathies: Report of an Autopsy Case. ( 29249116 )
2017
33
Cutaneous manifestations of Churg-Strauss syndrome: key to diagnosis. ( 29267447 )
2017
34
Ventricular tachycardia as the first manifestation of Churg-Strauss syndrome. ( 30546698 )
2017
35
Churg-Strauss syndrome that presented with mediastinal lymphadenopathy and calculous cholecystitis. ( 26767873 )
2016
36
Erratum to: Bowel perforations in a patient affected by Churg-Strauss syndrome under high-dose steroid treatment: will alternative drugs reduce risk of surgery? ( 26740233 )
2016
37
A patient with Churg-Strauss syndrome complicated with pulmonary hemoptysis. ( 27041254 )
2016
38
Churg-Strauss syndrome associated with antiphospholipid antibodies in a patient with retinal vasculitis. ( 27068137 )
2016
39
Optimal therapy and prospects for new medicines in eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). ( 27191665 )
2016
40
Churg-Strauss Syndrome: Singulair or Silicone (or both?). ( 27228637 )
2016
41
Churg-Strauss syndrome in a pediatric patient presenting with recurrent hemorrhagic stroke and mitral regurgitation due to a prolapsed mitral valve. ( 27381148 )
2016
42
Not All Coughs Are Asthma or Allergies: Churg-Strauss Syndrome. ( 27431867 )
2016
43
Echocardiographic Changes in Eosinophilic Endocarditis Induced by Churg-Strauss Syndrome. ( 27725542 )
2016
44
Native T1 Mapping Demonstrating Apical Thrombi in Eosinophilic Myocarditis Associated with Churg-Strauss Syndrome. ( 27826352 )
2016
45
Churg-Strauss syndrome with endocardial injury, clot formation in heart's chambers, and neurological complications. ( 27910080 )
2016
46
A case report and literature review of Churg-Strauss syndrome presenting with myocarditis. ( 28002315 )
2016
47
Usefulness of cardiac resonance imaging in Churg-Strauss syndrome. ( 25000251 )
2016
48
Letter to the editor: Colonic findings in a patient with relapse of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). ( 25795174 )
2016
49
[A case of hemorrhagic cholecystitis associated with Churg-Strauss syndrome]. ( 26853987 )
2016
50
Cardiac tamponade leading to the diagnosis of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome): a case report and review of the literature. ( 25070496 )
2015
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Variations for Allergic Angiitis

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Expression for Allergic Angiitis

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Search GEO for disease gene expression data for Allergic Angiitis.
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Pathways for Allergic Angiitis

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GO Terms for Allergic Angiitis

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Sources for Allergic Angiitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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