ABPA
MCID: ALL008
MIFTS: 50

Allergic Bronchopulmonary Aspergillosis (ABPA)

Categories: Genetic diseases, Immune diseases, Infectious diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Allergic Bronchopulmonary Aspergillosis

MalaCards integrated aliases for Allergic Bronchopulmonary Aspergillosis:

Name: Allergic Bronchopulmonary Aspergillosis 12 75 53 15 17
Aspergillosis, Allergic Bronchopulmonary 53 44 72
Allergic Bronchopulmonary Mycosis 53 72
Aspergillosis Allergic Bronchopulmonary 55
Pulmonary Aspergillus Disease 12
Hinson-Pepys Disease 53
Abpa 53

Classifications:



External Ids:

Disease Ontology 12 DOID:13166
ICD9CM 35 518.6
MeSH 44 D001229
NCIt 50 C84547
SNOMED-CT 68 37981002
ICD10 33 B44.81
UMLS 72 C0004031 C2931854

Summaries for Allergic Bronchopulmonary Aspergillosis

NIH Rare Diseases : 53 Allergic bronchopulmonary aspergillosis is an allergic lung reaction to a type of fungus (Aspergillus fumigatus). Symptoms vary, but may include wheezing, bronchial hyperreactivity, hemoptysis, productive cough, low-grade fever, malaise, and weight loss. It is more common in people who have asthma or cystic fibrosis. The recommended treatment for allergic bronchopulmonary aspergillosis is itraconazole, a prescription antifungal medication. Oral corticosteroids, like prednisone, may also be helpful. The clinical course of allergic bronchopulmonary aspergillosis is variable. Many people with this condition can be stabilized for long periods when treated. However, only about 50% of patients achieve long-lasting remission and many require recurrent courses of treatment.

MalaCards based summary : Allergic Bronchopulmonary Aspergillosis, also known as aspergillosis, allergic bronchopulmonary, is related to ige responsiveness, atopic and cystic fibrosis. An important gene associated with Allergic Bronchopulmonary Aspergillosis is CFTR (CF Transmembrane Conductance Regulator), and among its related pathways/superpathways are Bacterial infections in CF airways and Immune response IFN gamma signaling pathway. The drugs Miconazole and Omalizumab have been mentioned in the context of this disorder. Affiliated tissues include lung, colon and testes, and related phenotypes are cough and asthma

Disease Ontology : 12 An aspergillosis that involves an allergic reaction due to the spores of Aspergillus moulds (A. fumigatus), which colonizes the mucus in the airways causing inflammation. The disease has symptom cough, has symptom wheezing and has symptom fever.

Wikipedia : 75 Allergic bronchopulmonary aspergillosis (ABPA) is a condition characterised by an exaggerated response... more...

Related Diseases for Allergic Bronchopulmonary Aspergillosis

Diseases in the Allergic Bronchopulmonary Aspergillosis family:

Allergic Bronchopulmonary Aspergillosis, Familial

Diseases related to Allergic Bronchopulmonary Aspergillosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 179)
# Related Disease Score Top Affiliating Genes
1 ige responsiveness, atopic 31.2 IL5 IL4
2 cystic fibrosis 31.2 SFTPD MBL2 CFTR
3 aspergillosis 31.0 SFTPD SFTPA2 MBL2 IL5 IL4 CFTR
4 cryptococcosis 31.0 MBL2 IL4
5 rhinitis 31.0 IL5 IL4 EPX
6 hypereosinophilic syndrome 31.0 IL5 IL4 EPX CCL17
7 invasive aspergillosis 30.9 SFTPD MBL2
8 idiopathic interstitial pneumonia 30.9 SFTPD SFTPA2 IL4
9 cough variant asthma 30.9 IL5 IL4
10 churg-strauss syndrome 30.9 IL5 CCL17
11 gastroenteritis 30.8 IL5 IL4
12 dermatitis 30.8 IL5 IL4 CCL17
13 allergic rhinitis 30.7 IL5 IL4 EPX
14 allergic hypersensitivity disease 30.6 IL5 IL4 EPX CCL17
15 eosinophilic gastroenteritis 30.5 IL5 EPX
16 respiratory allergy 30.5 IL5 IL4
17 eosinophilic pneumonia 30.5 SFTPD IL5 CCL17
18 pollen allergy 30.4 IL5 EPX
19 pneumonia 30.4 SFTPD MBL2 IL5
20 food allergy 30.4 IL5 IL4 EPX
21 allergic asthma 30.3 IL5 IL4 EPX CCL17
22 conjunctivitis 30.2 IL5 IL4 EPX
23 lung disease 30.1 SFTPD SFTPA2 MBL2 IL5 CFTR
24 asthma 30.0 IL5 IL4 EPX CFTR CCL17
25 dermatitis, atopic 29.9 IL5 IL4 EPX CCL17
26 pulmonary eosinophilia 29.2 SFTPD IL5 IL4 EPX CCL17
27 allergic bronchopulmonary aspergillosis, familial 12.8
28 plastic bronchitis 11.6
29 bronchiectasis 11.2
30 fibrosis of extraocular muscles, congenital, 1 11.0
31 pulmonary fibrosis 10.7
32 pulmonary tuberculosis 10.7
33 respiratory failure 10.6
34 nickel allergic contact dermatitis 10.5 IL5 IL4
35 eosinophilic granulomatosis with polyangiitis 10.5
36 egg allergy 10.5 IL5 IL4
37 scleritis 10.5 IL5 IL4
38 atopic keratoconjunctivitis 10.5 IL5 IL4
39 sulfamethoxazole allergy 10.5 IL5 IL4
40 trichinosis 10.5 IL5 IL4
41 intrinsic asthma 10.5 IL5 IL4
42 angiostrongyliasis 10.5 IL5 IL4
43 gaucher disease, type ii 10.5 IL5 IL4
44 bronchitis 10.5
45 non-suppurative otitis media 10.5 IL5 IL4
46 eosinophilic meningitis 10.5 IL5 IL4
47 latex allergy 10.5 IL5 IL4
48 eosinophilic gastritis 10.5 IL5 IL4
49 chronic conjunctivitis 10.5 IL5 IL4
50 filarial elephantiasis 10.5 IL5 IL4

Graphical network of the top 20 diseases related to Allergic Bronchopulmonary Aspergillosis:



Diseases related to Allergic Bronchopulmonary Aspergillosis

Symptoms & Phenotypes for Allergic Bronchopulmonary Aspergillosis

Human phenotypes related to Allergic Bronchopulmonary Aspergillosis:

32 (show all 12)
# Description HPO Frequency HPO Source Accession
1 cough 32 hallmark (90%) HP:0012735
2 asthma 32 hallmark (90%) HP:0002099
3 abnormal eosinophil morphology 32 hallmark (90%) HP:0001879
4 weight loss 32 frequent (33%) HP:0001824
5 cerebral cortical atrophy 32 frequent (33%) HP:0002120
6 bronchiectasis 32 frequent (33%) HP:0002110
7 low-grade fever 32 frequent (33%) HP:0011134
8 respiratory insufficiency 32 occasional (7.5%) HP:0002093
9 emphysema 32 occasional (7.5%) HP:0002097
10 pulmonary arterial hypertension 32 occasional (7.5%) HP:0002092
11 hemoptysis 32 occasional (7.5%) HP:0002105
12 abnormal fingernail morphology 32 occasional (7.5%) HP:0001231

MGI Mouse Phenotypes related to Allergic Bronchopulmonary Aspergillosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.5 CCL17 CFTR EPX IL4 IL5 MBL2
2 immune system MP:0005387 9.17 CCL17 CFTR EPX IL4 IL5 MBL2

Drugs & Therapeutics for Allergic Bronchopulmonary Aspergillosis

Drugs for Allergic Bronchopulmonary Aspergillosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 70)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
2
Omalizumab Approved, Investigational Phase 4 242138-07-4
3
Itraconazole Approved, Investigational Phase 4 84625-61-6 55283
4 Pharmaceutical Solutions Phase 4
5 Immunoglobulin G Phase 4
6 Immunologic Factors Phase 4
7 Antifungal Agents Phase 4
8 Anti-Infective Agents Phase 4
9 14-alpha Demethylase Inhibitors Phase 4
10 Anti-Allergic Agents Phase 4
11 Hormones Phase 4
12 Cytochrome P-450 CYP3A Inhibitors Phase 4
13 Cytochrome P-450 Enzyme Inhibitors Phase 4
14 Respiratory System Agents Phase 4
15 Steroid Synthesis Inhibitors Phase 4
16 Immunoglobulin E Phase 4
17
Hydroxyitraconazole Phase 4
18 Antibodies Phase 4
19 Immunoglobulins Phase 4
20 Hormone Antagonists Phase 4
21 Anti-Asthmatic Agents Phase 4
22 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
23
Amphotericin B Approved, Investigational Phase 2, Phase 3 1397-89-3 14956 5280965
24
Voriconazole Approved, Investigational Phase 2, Phase 3 137234-62-9 71616
25
Budesonide Approved Phase 2, Phase 3 51333-22-3 63006 5281004
26
deoxycholic acid Approved Phase 2, Phase 3 83-44-3 222528
27
Prednisolone phosphate Approved, Vet_approved Phase 2, Phase 3 302-25-0
28
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
29
Methylprednisolone hemisuccinate Approved Phase 2, Phase 3 2921-57-5
30
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
31
Fluticasone Approved, Experimental Phase 2, Phase 3 90566-53-3 62924
32
Vitamin D3 Approved, Nutraceutical Phase 2, Phase 3 67-97-0 6221 5280795
33
Ergocalciferol Approved, Nutraceutical Phase 2, Phase 3 50-14-6 5280793
34
Vitamin D Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 1406-16-2
35
Calcium Approved, Nutraceutical Phase 2, Phase 3 7440-70-2 271
36
Prednisolone hemisuccinate Experimental Phase 2, Phase 3 2920-86-7
37 Liposomal amphotericin B Phase 2, Phase 3
38 Antiparasitic Agents Phase 2, Phase 3
39 Anti-Bacterial Agents Phase 2, Phase 3
40 Antiprotozoal Agents Phase 2, Phase 3
41 Antiemetics Phase 2, Phase 3
42 Gastrointestinal Agents Phase 2, Phase 3
43 Neuroprotective Agents Phase 2, Phase 3
44 Peripheral Nervous System Agents Phase 2, Phase 3
45 Protective Agents Phase 2, Phase 3
46 Autonomic Agents Phase 2, Phase 3
47 Micronutrients Phase 2, Phase 3
48 Trace Elements Phase 2, Phase 3
49 Vitamin D2 Phase 2, Phase 3
50 Vitamins Phase 2, Phase 3

Interventional clinical trials:

(show all 26)
# Name Status NCT ID Phase Drugs
1 Immunoglobulin Replacement Therapy for Immunoglobulin G Subclass 2 Deficient Patients With Bronchiectasis- A Proof of Concept Study Not yet recruiting NCT03737617 Phase 4 Cuvitru 20 % Injectable Solution
2 An Exploratory, Randomized, Double-blind, Placebo Controlled Study to Assess the Efficacy of Multiple Doses of Omalizumab in Cystic Fibrosis Complicated by Allergic Bronchopulmonary Aspergillosis (ABPA) Terminated NCT00787917 Phase 4 Omalizumab;Placebo;Itraconazole
3 Randomized Controlled Trial on the Efficacy and Safety of Two Different Glucocorticoid Dose Regimens in Allergic Bronchopulmonary Aspergillosis Completed NCT00974766 Phase 2, Phase 3 Glucocorticoids;Glucocorticoids
4 A Randomized Controlled Trial of Voriconazole in Allergic Bronchopulmonary Aspergillosis Completed NCT01621321 Phase 2, Phase 3 Prednisolone;Voriconazole
5 A Study Evaluating Vitamin D in Allergic Bronchopulmonary Aspergillosis Complicating Asthma Completed NCT03133299 Phase 2, Phase 3 Glucocorticoids;Vitamin D
6 A Randomized Controlled Trial of Inhaled Amphotericin B for Maintaining Remission in Allergic Bronchopulmonary Aspergillosis Completed NCT01857479 Phase 2, Phase 3 Inhaled budesonide;Inhaled amphotericin
7 Monotherapy of Itraconazole Versus Prednisolone in Allergic Bronchopulmonary Aspergillosis Completed NCT01321827 Phase 2, Phase 3 Glucocorticoids;Itraconazole
8 A Randomized Trial of Itraconazole in Acute Stages of Allergic Bronchopulmonary Aspergillosis Recruiting NCT02440009 Phase 2, Phase 3 Itraconazole;Glucocorticoids
9 A Randomized Controlled Trial to Compare the Clinical Outcomes of Six Months Versus 12 Months of Oral Itraconazole Therapy for Management of Treatment naïve Subjects With Chronic Pulmonary Aspergillosis Recruiting NCT03920527 Phase 3 Itraconazole 400 mg
10 A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study to Evaluate the Safety, Tolerability, & Pharmacokinetics of Itraconazole Administered as a Dry Powder for Inhalation (PUR1900) in Asthmatic Patients With ABPA Recruiting NCT03960606 Phase 2
11 Evaluation of a Therapeutic Strategy Including Nebulised Liposomal Amphotericin B (Ambisome®) in Maintenance Treatment of Allergic Bronchopulmonary Aspergillosis (Cystic Fibrosis Excluded) Active, not recruiting NCT02273661 Phase 2 Liposomal amphotericin B (Ambisome®);placebo
12 A Randomized, Double Blind Placebo-controlled Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Pharmacodynamics of Single and Multiple Ascending Doses of QBW251 in Healthy Subjects and Multiple Doses in Cystic Fibrosis Patients Terminated NCT02190604 Phase 1, Phase 2 Placebo;QBW251
13 A Randomised, Single-blind, Placebo-controlled, Study to Assess the Safety and Tolerability of Single Escalating and Repeat, Inhaled Doses of PC945 in Healthy Subjects Combined With a Randomised, Single-blind, Placebo-controlled, Parallel Group to Assess the Safety and Tolerability of a Single Dose of Inhaled PC945 in Subjects With Mild Asthma Completed NCT02715570 Phase 1 PC945 - single doses;Placebo - single doses;PC945 - repeat doses;Placebo - repeat doses
14 A Randomised, Double-blind, Placebo-controlled, Cross-over Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Ascending Oral Doses of GSK2239633 in Healthy Male Subjects. Completed NCT01371812 Phase 1 GSK2239633;Placebo
15 Role of Thymus-And Activation-Regulated Chemokine (TARC) In Diagnosis Of Allergic Bronchopulmonary Aspergillosis Unknown status NCT03267394
16 Diagnostic Value of MRI for Allergic Broncho-Pulmonary Aspergilloses Unknown status NCT03265366
17 SCCOR in Host Factors in Chronic Lung Diseases: Mechanisms of Immune Tolerance and Inflammation in Allergic Bronchopulmonary Aspergillosis (ABPA) in Patients With Cystic Fibrosis Completed NCT00585364
18 Open-label Vitamin D Trial for Patients With Cystic Fibrosis and Allergic Bronchopulmonary Aspergillosis Completed NCT01222273
19 Clinical Presentation and Bronchial Inflammation of Allergic Bronchopulmonary Aspergillosis (ABPA) in Patients With Cystic Fibrosis Completed NCT00906568
20 Diagnostic Accuracy of Lung MRI to Detect Allergic Broncho-pulmonary Aspergillosis in Cystic Fibrosis Completed NCT02853175
21 Interest of TARC Serum Marker for Follow-up of Patients With Allergic Broncho-Pulmonary Aspergillosis (ABPA), Excluding Cystic Fibrosis Completed NCT01710930
22 Duplication in CHIT1 Gene and the Risk for Aspergillus Lung Disease in CF Patients Completed NCT01572870
23 Invasive Mould Infections in Indian ICUs - Descriptive Epidemiology, Management and Outcome Completed NCT02683642
24 Cytokine Profile of Allergic Bronchopulmonary Aspergillosis and Its Relevance to Severity and Exacerbation. Recruiting NCT03643185
25 CF And Effects of Drugs Mixed Ex Vivo With Sputum for Mucolytic Treatment to Lung Mucin Recruiting NCT01533636
26 Characterizing Asthma Sputum Elasticity in the UCSF Severe Asthma Research Program Recruiting NCT02103348

Search NIH Clinical Center for Allergic Bronchopulmonary Aspergillosis

Cochrane evidence based reviews: aspergillosis, allergic bronchopulmonary

Genetic Tests for Allergic Bronchopulmonary Aspergillosis

Anatomical Context for Allergic Bronchopulmonary Aspergillosis

MalaCards organs/tissues related to Allergic Bronchopulmonary Aspergillosis:

41
Lung, Colon, Testes, T Cells, Skin, Bone, Neutrophil

Publications for Allergic Bronchopulmonary Aspergillosis

Articles related to Allergic Bronchopulmonary Aspergillosis:

(show top 50) (show all 1650)
# Title Authors PMID Year
1
Clinical significance of decline in serum IgE levels in allergic bronchopulmonary aspergillosis. 9 38
19800210 2010
2
Identification and characterization of a laminin-binding protein of Aspergillus fumigatus: extracellular thaumatin domain protein (AfCalAp). 9 38
19429746 2009
3
Itraconazole, an effective adjunctive treatment for allergic bronchopulmonary aspergillosis. 9 38
19862941 2009
4
Treatment of allergic bronchopulmonary aspergillosis (ABPA) in CF with anti-IgE antibody (omalizumab). 9 38
19009619 2008
5
[Aspergillosis for the pulmonologist]. 9 38
19019289 2008
6
Partial correction of the CFTR-dependent ABPA mouse model with recombinant adeno-associated virus gene transfer of truncated CFTR gene. 9 38
18023072 2008
7
Distinct alleles of mannose-binding lectin (MBL) and surfactant proteins A (SP-A) in patients with chronic cavitary pulmonary aspergillosis and allergic bronchopulmonary aspergillosis. 9 38
17311505 2007
8
Elevated levels of mannan-binding lectin [corrected] (MBL) and eosinophilia in patients of bronchial asthma with allergic rhinitis and allergic bronchopulmonary aspergillosis associate with a novel intronic polymorphism in MBL. 9 38
16487239 2006
9
Allergic bronchopulmonary aspergillosis in a patient with cystic fibrosis: diagnostic criteria when the IgE level is less than 500 IU/mL. 9 38
16312174 2005
10
Time course of antibody response to recombinant Aspergillus fumigatus antigens in cystic fibrosis with and without ABPA. 9 38
15853950 2005
11
Role of collectins in innate immunity against aspergillosis. 9 38
16114131 2005
12
Aspergillus antigens: which are important? 9 38
16110811 2005
13
IgE antibody to Aspergillus fumigatus recombinant allergens in cystic fibrosis patients with allergic bronchopulmonary aspergillosis. 9 38
14763934 2004
14
Increased sensitivity to IL-4 in cystic fibrosis patients with allergic bronchopulmonary aspergillosis. 9 38
14674938 2004
15
[A case of pleural effusion associated with allergic bronchopulmonary aspergillosis during a relapse of the disease]. 9 38
14727554 2003
16
Surfactant protein D in serum from patients with allergic bronchopulmonary aspergillosis. 9 38
14582909 2003
17
Cystic fibrosis transmembrane conductance regulator gene mutations: do they play a role in the aetiology of allergic bronchopulmonary aspergillosis? 9 38
11994102 2002
18
Immunoglobulin-E and anti-IgE treatment in lung disease. 9 38
11980283 2001
19
The spectrum of CFTR-related disease. 9 38
11446679 2001
20
Frequency of cystic fibrosis transmembrane conductance regulator gene mutations and 5T allele in patients with allergic bronchopulmonary aspergillosis. 9 38
11243954 2001
21
'CFTR-opathies': disease phenotypes associated with cystic fibrosis transmembrane regulator gene mutations. 9 38
11737931 2001
22
Increased sensitivity to IL-4 in patients with allergic bronchopulmonary aspergillosis. 9 38
11146389 2000
23
[Hypereosinophilic reactions in hypersensitivity states]. 9 38
10808315 2000
24
Allergic bronchopulmonary aspergillosis in two patients with cystic fibrosis. 9 38
10731875 2000
25
[Successful treatment of allergic bronchopulmonary aspergillosis with erythromycin and fluconazole]. 9 38
10390974 1999
26
Allergic bronchopulmonary aspergillosis in cystic fibrosis: role of atopy and response to itraconazole. 9 38
10027433 1999
27
Immunological characterization of Asp f 2, a major allergen from Aspergillus fumigatus associated with allergic bronchopulmonary aspergillosis. 9 38
9784519 1998
28
[Allergic bronchopulmonary aspergillosis effectively treated with itraconazole]. 9 38
9866981 1998
29
[Two cases of Churg-Strauss syndrome with impaired prognosis]. 9 38
9745302 1998
30
IgE down regulation and cytokine induction by Aspergillus antigens in human allergic bronchopulmonary aspergillosis. 9 38
9523846 1998
31
Immunodominant peptide epitopes of allergen, Asp f 1 from the fungus Aspergillus fumigatus. 9 38
9864052 1998
32
Allergic bronchopulmonary aspergillosis with low serum IgE levels in a child with cystic fibrosis. 9 38
9314361 1997
33
Purification of a major allergen, Asp f 2 binding to IgE in allergic bronchopulmonary aspergillosis, from culture filtrate of Aspergillus fumigatus. 9 38
9215251 1997
34
Cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations in allergic bronchopulmonary aspergillosis. 9 38
8659542 1996
35
Improved diagnosis of allergic bronchopulmonary aspergillosis with gp66 (formerly antigen 7) of Aspergillus fumigatus for specific IgE detection. 9 38
8765818 1996
36
Cross-reactivity between Aspergillus fumigatus and Penicillium. 9 38
8645995 1996
37
Molecular cloning and expression of a recombinant Aspergillus fumigatus protein Asp f II with significant immunoglobulin E reactivity in allergic bronchopulmonary aspergillosis. 9 38
9273358 1996
38
Development of immune responses to Aspergillus at an early age in children with cystic fibrosis. 9 38
7952609 1994
39
IgE and eosinophil regulation in a murine model of allergic aspergillosis. 9 38
7964167 1994
40
Rise in total IgE as an indicator of allergic bronchopulmonary aspergillosis in cystic fibrosis. 9 38
7974292 1994
41
Activated T cells and cytokines in bronchoalveolar lavages from patients with various lung diseases associated with eosinophilia. 9 38
7921434 1994
42
Aspergillus ribotoxins react with IgE and IgG antibodies of patients with allergic bronchopulmonary aspergillosis. 9 38
8195680 1994
43
Recombinant expression and antigenic properties of a 32-kilodalton extracellular alkaline protease, representing a possible virulence factor from Aspergillus fumigatus. 9 38
8112866 1994
44
Hyperimmune serum modulates allergic response to spores in a murine model of allergic aspergillosis. 9 38
8283139 1994
45
Serum immunoglobulins E and G anti-Aspergillus fumigatus antibody in patients with cystic fibrosis who have allergic bronchopulmonary aspergillosis. 9 38
2230542 1990
46
T- and B-cell dysregulation of IgE synthesis in cystic fibrosis patients with allergic bronchopulmonary aspergillosis. 9 38
2137739 1990
47
Allergic bronchopulmonary aspergillosis complicated by eosinophilic chronic rhinosinusitis successfully treated with mepolizumab. 38
31346471 2019
48
Elevated serum levels of periostin in patients with allergic bronchopulmonary aspergillosis. 38
31173398 2019
49
A unique case of hydropneumothorax in allergic bronchopulmonary aspergillosis. 38
31338287 2019
50
Bronchiectasis in India: results from the European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC) and Respiratory Research Network of India Registry. 38
31402007 2019

Variations for Allergic Bronchopulmonary Aspergillosis

Expression for Allergic Bronchopulmonary Aspergillosis

Search GEO for disease gene expression data for Allergic Bronchopulmonary Aspergillosis.

Pathways for Allergic Bronchopulmonary Aspergillosis

Pathways related to Allergic Bronchopulmonary Aspergillosis according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.76 SFTPD IL4 CFTR
2
Show member pathways
11.74 IL5 IL4 CCL17
3 11.68 SFTPD SFTPA2 MBL2
4
Show member pathways
11.59 IL5 IL4 CFTR CCL17
5 11.23 SFTPA2 IL5 IL4
6
Show member pathways
11.2 SFTPD SFTPA2
7
Show member pathways
11.16 SFTPD SFTPA2
8 11.13 IL5 IL4 CCL17
9 11.03 IL5 IL4
10 11 IL5 IL4
11 10.94 IL5 IL4
12 10.87 IL5 IL4
13
Show member pathways
10.83 SFTPD SFTPA2
14 10.81 IL5 IL4 CCL17
15 10.46 IL5 IL4 CCL17

GO Terms for Allergic Bronchopulmonary Aspergillosis

Cellular components related to Allergic Bronchopulmonary Aspergillosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 SFTPD SFTPA2 MBL2 IL5 IL4 EPX
2 collagen trimer GO:0005581 9.33 SFTPD SFTPA2 MBL2
3 multivesicular body GO:0005771 9.32 SFTPD SFTPA2
4 clathrin-coated endocytic vesicle GO:0045334 9.26 SFTPD SFTPA2
5 extracellular space GO:0005615 9.17 SFTPD SFTPA2 MBL2 IL5 IL4 EPX

Biological processes related to Allergic Bronchopulmonary Aspergillosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.43 SFTPD MBL2 EPX
2 positive regulation of B cell proliferation GO:0030890 9.37 IL5 IL4
3 toll-like receptor signaling pathway GO:0002224 9.32 SFTPD SFTPA2
4 respiratory gaseous exchange GO:0007585 9.16 SFTPD SFTPA2
5 surfactant homeostasis GO:0043129 8.96 SFTPD SFTPA2
6 positive regulation of phagocytosis GO:0050766 8.8 SFTPD SFTPA2 MBL2

Molecular functions related to Allergic Bronchopulmonary Aspergillosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.33 IL5 IL4 CCL17
2 lipopolysaccharide binding GO:0001530 9.26 SFTPD SFTPA2
3 carbohydrate binding GO:0030246 9.13 SFTPD SFTPA2 MBL2
4 monosaccharide binding GO:0048029 8.62 SFTPD SFTPA2

Sources for Allergic Bronchopulmonary Aspergillosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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