ABPA
MCID: ALL008
MIFTS: 53

Allergic Bronchopulmonary Aspergillosis (ABPA)

Categories: Genetic diseases, Immune diseases, Infectious diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Allergic Bronchopulmonary Aspergillosis

MalaCards integrated aliases for Allergic Bronchopulmonary Aspergillosis:

Name: Allergic Bronchopulmonary Aspergillosis 12 74 52 15 17
Aspergillosis, Allergic Bronchopulmonary 52 43 71
Allergic Bronchopulmonary Mycosis 52 71
Aspergillosis Allergic Bronchopulmonary 54
Pulmonary Aspergillus Disease 12
Hinson-Pepys Disease 52
Abpa 52

Classifications:



Summaries for Allergic Bronchopulmonary Aspergillosis

NIH Rare Diseases : 52 Allergic bronchopulmonary aspergillosis is an allergic lung reaction to a type of fungus (Aspergillus fumigatus ). Symptoms vary, but may include wheezing , bronchial hyperreactivity, hemoptysis , productive cough, low-grade fever, malaise , and weight loss. It is more common in people who have asthma or cystic fibrosis . The recommended treatment for allergic bronchopulmonary aspergillosis is itraconazole , a prescription antifungal medication. Oral corticosteroids , like prednisone , may also be helpful. The clinical course of allergic bronchopulmonary aspergillosis is variable. Many people with this condition can be stabilized for long periods when treated. However, only about 50% of patients achieve long-lasting remission and many require recurrent courses of treatment.

MalaCards based summary : Allergic Bronchopulmonary Aspergillosis, also known as aspergillosis, allergic bronchopulmonary, is related to cystic fibrosis and aspergillosis. An important gene associated with Allergic Bronchopulmonary Aspergillosis is CFTR (CF Transmembrane Conductance Regulator), and among its related pathways/superpathways are Akt Signaling and Cytokine Signaling in Immune system. The drugs Benralizumab and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include lung, colon and testes, and related phenotypes are cough and asthma

Disease Ontology : 12 An aspergillosis that involves an allergic reaction due to the spores of Aspergillus moulds (A. fumigatus), which colonizes the mucus in the airways causing inflammation. The disease has symptom cough, has symptom wheezing and has symptom fever.

Wikipedia : 74 Allergic bronchopulmonary aspergillosis (ABPA) is a condition characterised by an exaggerated response... more...

Related Diseases for Allergic Bronchopulmonary Aspergillosis

Diseases in the Allergic Bronchopulmonary Aspergillosis family:

Allergic Bronchopulmonary Aspergillosis, Familial

Diseases related to Allergic Bronchopulmonary Aspergillosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 344)
# Related Disease Score Top Affiliating Genes
1 cystic fibrosis 31.4 SFTPD MBL2 IL10 CFTR CCL17
2 aspergillosis 31.3 SFTPD SFTPA2 SFTPA1 MBL2 IL5 IL4
3 churg-strauss syndrome 31.2 IL5 IL10 CCL17
4 extrinsic allergic alveolitis 30.9 SFTPD IL10 IGHE
5 cough variant asthma 30.8 IL5 IL4 IGHE
6 idiopathic interstitial pneumonia 30.7 SFTPD SFTPA2 SFTPA1 IL4 IFNG
7 idiopathic bronchiectasis 30.7 IFNG HLA-DRB1 CFTR
8 nontuberculous mycobacterial lung disease 30.7 HLA-DRB1 CFTR
9 pulmonary tuberculosis 30.6 MBL2 IL4 IL10 IFNG HLA-DRB1
10 eosinophilic gastroenteritis 30.6 IL5 IL4 EPX
11 drug allergy 30.5 IL5 IGHE ENPP3
12 strongyloidiasis 30.4 IL5 IGHE IFNG
13 eosinophilic pneumonia 30.4 SFTPD IL5 IL4 CCL22 CCL17
14 cryptococcosis 30.4 MBL2 IL4 IL10 IFNG
15 lung abscess 30.4 IGES IFNG FLNC
16 pulmonary fibrosis 30.4 SFTPD SFTPA2 SFTPA1 CCL22 CCL17
17 respiratory failure 30.3 SFTPD IL5 IL10 EPX CFTR CCL17
18 hyper ige syndrome 30.3 IL4 IGHE IGES IFNG
19 rhinitis 30.3 IL5 IL4 IL10 IGHE IFNG EPX
20 tetanus 30.3 IL5 IL4 IL10 IFNG
21 pollen allergy 30.3 IL5 EPX ENPP3
22 ige responsiveness, atopic 30.3 IL5 IL4 IL10 IGHE IGES IFNG
23 urticaria 30.2 IL5 IL4 IGHE ENPP3
24 mycobacterium tuberculosis 1 30.2 MBL2 IL4 IL10 IFNG
25 bronchiolitis obliterans 30.2 SFTPD IL10 IFNG
26 endomyocardial fibrosis 30.2 IL5 IL4 IL10 EPX
27 endocarditis 30.1 IL10 IFNG EPX
28 bronchitis 30.1 IL5 IL4 IL10 IGHE CFTR CCR3
29 bronchiolitis 30.0 SFTPD IL5 IL4 IL10 IFNG
30 invasive aspergillosis 30.0 SFTPD MBL2 IL10 IFNG FLNC
31 proteasome-associated autoinflammatory syndrome 1 30.0 IL5 IL4 IL10 IFNG
32 allergic asthma 29.9 IL5 IL4 IL10 IGHE IFNG EPX
33 bacterial infectious disease 29.9 MBL2 IL10 IFNG CFTR
34 pulmonary eosinophilia 29.9 SFTPD IL5 IL4 EPX CCR3 CCL17
35 pulmonary disease, chronic obstructive 29.9 SFTPD IL5 IL4 IL10 CFTR CCR3
36 crohn's disease 29.8 IL4 IL10 IFNG HLA-DRB1
37 gastroenteritis 29.6 IL5 IL4 IL10 IFNG EPX
38 hypereosinophilic syndrome 29.6 IL5 IL4 IL10 IGHE IGES IFNG
39 immune deficiency disease 29.4 MBL2 IL4 IL10 IFNG CCR3
40 autoimmune disease 29.4 MBL2 IL5 IL4 IL10 IFNG HLA-DRB1
41 conjunctivitis 29.4 IL5 IL4 IL10 IGHE IFNG EPX
42 dermatitis 29.2 IL5 IL4 IL10 IGHE IFNG CCL22
43 lung disease 29.2 SFTPD SFTPA2 SFTPA1 MBL2 IL5 IL4
44 otitis media 29.0 SFTPA2 SFTPA1 MBL2 IL5 IL4 IL10
45 respiratory allergy 28.8 IL5 IL4 IL10 IGHE FLNC CCR3
46 food allergy 28.7 IL5 IL4 IL10 IGHE IGES IFNG
47 allergic rhinitis 28.7 IL5 IL4 IL10 IGHE IGES IFNG
48 pneumonia 27.9 SFTPD SFTPA2 SFTPA1 MBL2 IL5 IL4
49 allergic hypersensitivity disease 27.4 SFTPD IL5 IL4 IL10 IGHE IGES
50 asthma 26.9 SFTPD MBL2 IL5 IL4 IL10 IGHE

Graphical network of the top 20 diseases related to Allergic Bronchopulmonary Aspergillosis:



Diseases related to Allergic Bronchopulmonary Aspergillosis

Symptoms & Phenotypes for Allergic Bronchopulmonary Aspergillosis

Human phenotypes related to Allergic Bronchopulmonary Aspergillosis:

31 (show all 12)
# Description HPO Frequency HPO Source Accession
1 cough 31 hallmark (90%) HP:0012735
2 asthma 31 hallmark (90%) HP:0002099
3 abnormal eosinophil morphology 31 hallmark (90%) HP:0001879
4 cerebral cortical atrophy 31 frequent (33%) HP:0002120
5 weight loss 31 frequent (33%) HP:0001824
6 bronchiectasis 31 frequent (33%) HP:0002110
7 low-grade fever 31 frequent (33%) HP:0011134
8 respiratory insufficiency 31 occasional (7.5%) HP:0002093
9 emphysema 31 occasional (7.5%) HP:0002097
10 pulmonary arterial hypertension 31 occasional (7.5%) HP:0002092
11 hemoptysis 31 occasional (7.5%) HP:0002105
12 abnormal fingernail morphology 31 occasional (7.5%) HP:0001231

MGI Mouse Phenotypes related to Allergic Bronchopulmonary Aspergillosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.93 CCL17 CCR3 CFTR ENPP3 EPX IFNG
2 immune system MP:0005387 9.77 CCL17 CCL22 CCR3 CFTR ENPP3 EPX
3 respiratory system MP:0005388 9.32 CCR3 CFTR ENPP3 FLNC IFNG IL10

Drugs & Therapeutics for Allergic Bronchopulmonary Aspergillosis

Drugs for Allergic Bronchopulmonary Aspergillosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 68)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Benralizumab Approved, Investigational Phase 4 1044511-01-4
2
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
3
Itraconazole Approved, Investigational Phase 4 84625-61-6 55283
4
Omalizumab Approved, Investigational Phase 4 242138-07-4
5 Antibodies, Monoclonal Phase 4
6 Pharmaceutical Solutions Phase 4
7 Immunoglobulin G Phase 4
8 Immunologic Factors Phase 4
9 Anti-Infective Agents Phase 4
10 Antifungal Agents Phase 4
11 Cytochrome P-450 CYP3A Inhibitors Phase 4
12 Cytochrome P-450 Enzyme Inhibitors Phase 4
13 Anti-Asthmatic Agents Phase 4
14
Hydroxyitraconazole Phase 4
15 Hormone Antagonists Phase 4
16 Respiratory System Agents Phase 4
17 Steroid Synthesis Inhibitors Phase 4
18 Immunoglobulin E Phase 4
19 Antibodies Phase 4
20 Anti-Allergic Agents Phase 4
21 Hormones Phase 4
22 Immunoglobulins Phase 4
23
Amphotericin B Approved, Investigational Phase 2, Phase 3 1397-89-3 14956 5280965
24
Voriconazole Approved Phase 2, Phase 3 137234-62-9 71616
25
deoxycholic acid Approved Phase 2, Phase 3 83-44-3 222528
26
Budesonide Approved Phase 2, Phase 3 51333-22-3 63006 5281004
27
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
28
Methylprednisolone hemisuccinate Approved Phase 2, Phase 3 2921-57-5
29
Prednisolone phosphate Approved, Vet_approved Phase 2, Phase 3 302-25-0
30
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
31 Prednisolone acetate Approved, Vet_approved Phase 2, Phase 3 52-21-1
32
Fluticasone Approved, Experimental Phase 2, Phase 3 90566-53-3 62924
33
Ergocalciferol Approved, Nutraceutical Phase 2, Phase 3 50-14-6 5280793
34
Vitamin D Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 1406-16-2
35
Vitamin D3 Approved, Nutraceutical Phase 2, Phase 3 67-97-0 6221 5280795
36
Calcium Approved, Nutraceutical Phase 2, Phase 3 7440-70-2 271
37
Prednisolone hemisuccinate Experimental Phase 2, Phase 3 2920-86-7
38 Antiprotozoal Agents Phase 2, Phase 3
39 Antiparasitic Agents Phase 2, Phase 3
40 Anti-Bacterial Agents Phase 2, Phase 3
41 Liposomal amphotericin B Phase 2, Phase 3
42 Antiemetics Phase 2, Phase 3
43 Gastrointestinal Agents Phase 2, Phase 3
44 Neuroprotective Agents Phase 2, Phase 3
45 Autonomic Agents Phase 2, Phase 3
46 Protective Agents Phase 2, Phase 3
47 Vitamins Phase 2, Phase 3
48 Trace Elements Phase 2, Phase 3
49 Micronutrients Phase 2, Phase 3
50 Nutrients Phase 2, Phase 3

Interventional clinical trials:

(show all 28)
# Name Status NCT ID Phase Drugs
1 Phase IV, Single-Center, Open-Label Study Evaluating the Effects of an Anti-IL5 Receptor Alpha (Benralizumab) Monoclonal Antibody in the Treatment of Severe Asthma in Patients With Allergic Bronchopulmonary Aspergillosis Not yet recruiting NCT04108962 Phase 4 Fasenra, 30 Mg/mL Subcutaneous Solution
2 Immunoglobulin Replacement Therapy for Immunoglobulin G Subclass 2 Deficient Patients With Bronchiectasis- A Proof of Concept Study Not yet recruiting NCT03737617 Phase 4 Cuvitru 20 % Injectable Solution
3 An Exploratory, Randomized, Double-blind, Placebo Controlled Study to Assess the Efficacy of Multiple Doses of Omalizumab in Cystic Fibrosis Complicated by Allergic Bronchopulmonary Aspergillosis (ABPA) Terminated NCT00787917 Phase 4 Omalizumab;Placebo;Itraconazole
4 Randomized Controlled Trial on the Efficacy and Safety of Two Different Glucocorticoid Dose Regimens in Allergic Bronchopulmonary Aspergillosis Completed NCT00974766 Phase 2, Phase 3 Glucocorticoids;Glucocorticoids
5 A Randomized Controlled Trial of Voriconazole in Allergic Bronchopulmonary Aspergillosis Completed NCT01621321 Phase 2, Phase 3 Prednisolone;Voriconazole
6 A Study Evaluating Vitamin D in Allergic Bronchopulmonary Aspergillosis Complicating Asthma Completed NCT03133299 Phase 2, Phase 3 Glucocorticoids;Vitamin D
7 A Randomized Controlled Trial of Inhaled Amphotericin B for Maintaining Remission in Allergic Bronchopulmonary Aspergillosis Completed NCT01857479 Phase 2, Phase 3 Inhaled budesonide;Inhaled amphotericin
8 Monotherapy of Itraconazole Versus Prednisolone in Allergic Bronchopulmonary Aspergillosis Completed NCT01321827 Phase 2, Phase 3 Glucocorticoids;Itraconazole
9 A Randomized Trial of Itraconazole in Acute Stages of Allergic Bronchopulmonary Aspergillosis Recruiting NCT02440009 Phase 2, Phase 3 Itraconazole;Glucocorticoids
10 Open-Label Study to Evaluate the Efficacy and Safety of SCY-078 (Ibrexafungerp) in Patients With Fungal Diseases That Are Refractory to or Intolerant of Standard Antifungal Treatment (FURI) Recruiting NCT03059992 Phase 3 Ibrexafungerp
11 A Randomized Controlled Trial to Compare the Clinical Outcomes of Six Months Versus 12 Months of Oral Itraconazole Therapy for Management of Treatment naïve Subjects With Chronic Pulmonary Aspergillosis Recruiting NCT03920527 Phase 3 Itraconazole 400 mg
12 A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study to Evaluate the Safety, Tolerability, & Pharmacokinetics of Itraconazole Administered as a Dry Powder for Inhalation (PUR1900) in Asthmatic Patients With ABPA Recruiting NCT03960606 Phase 2
13 Evaluation of a Therapeutic Strategy Including Nebulised Liposomal Amphotericin B (Ambisome®) in Maintenance Treatment of Allergic Bronchopulmonary Aspergillosis (Cystic Fibrosis Excluded) Active, not recruiting NCT02273661 Phase 2 Liposomal amphotericin B (Ambisome®);placebo
14 A Randomized, Double Blind Placebo-controlled Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Pharmacodynamics of Single and Multiple Ascending Doses of QBW251 in Healthy Subjects and Multiple Doses in Cystic Fibrosis Patients Terminated NCT02190604 Phase 1, Phase 2 Placebo;QBW251
15 A Randomised, Single-blind, Placebo-controlled, Study to Assess the Safety and Tolerability of Single Escalating and Repeat, Inhaled Doses of PC945 in Healthy Subjects Combined With a Randomised, Single-blind, Placebo-controlled, Parallel Group to Assess the Safety and Tolerability of a Single Dose of Inhaled PC945 in Subjects With Mild Asthma Completed NCT02715570 Phase 1 PC945 - single doses;Placebo - single doses;PC945 - repeat doses;Placebo - repeat doses
16 A Randomised, Double-blind, Placebo-controlled, Cross-over Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Ascending Oral Doses of GSK2239633 in Healthy Male Subjects. Completed NCT01371812 Phase 1 GSK2239633;Placebo
17 Role of Thymus-And Activation-Regulated Chemokine (TARC) In Diagnosis Of Allergic Bronchopulmonary Aspergillosis Unknown status NCT03267394
18 Diagnostic Value of MRI for Allergic Broncho-Pulmonary Aspergilloses Unknown status NCT03265366
19 SCCOR in Host Factors in Chronic Lung Diseases: Mechanisms of Immune Tolerance and Inflammation in Allergic Bronchopulmonary Aspergillosis (ABPA) in Patients With Cystic Fibrosis Completed NCT00585364
20 Open-label Vitamin D Trial for Patients With Cystic Fibrosis and Allergic Bronchopulmonary Aspergillosis Completed NCT01222273
21 Clinical Presentation and Bronchial Inflammation of Allergic Bronchopulmonary Aspergillosis (ABPA) in Patients With Cystic Fibrosis Completed NCT00906568
22 Diagnostic Accuracy of Lung MRI to Detect Allergic Broncho-pulmonary Aspergillosis in Cystic Fibrosis Completed NCT02853175
23 Interest of TARC Serum Marker for Follow-up of Patients With Allergic Broncho-Pulmonary Aspergillosis (ABPA), Excluding Cystic Fibrosis Completed NCT01710930
24 Duplication in CHIT1 Gene and the Risk for Aspergillus Lung Disease in CF Patients Completed NCT01572870
25 Invasive Mould Infections in Indian ICUs - Descriptive Epidemiology, Management and Outcome Completed NCT02683642
26 Cytokine Profile of Allergic Bronchopulmonary Aspergillosis and Its Relevance to Severity and Exacerbation. Recruiting NCT03643185
27 CF And Effects of Drugs Mixed Ex Vivo With Sputum for Mucolytic Treatment to Lung Mucin Recruiting NCT01533636
28 Characterizing Asthma Sputum Elasticity in the UCSF Severe Asthma Research Program Recruiting NCT02103348

Search NIH Clinical Center for Allergic Bronchopulmonary Aspergillosis

Cochrane evidence based reviews: aspergillosis, allergic bronchopulmonary

Genetic Tests for Allergic Bronchopulmonary Aspergillosis

Anatomical Context for Allergic Bronchopulmonary Aspergillosis

MalaCards organs/tissues related to Allergic Bronchopulmonary Aspergillosis:

40
Lung, Colon, Testes, T Cells, Skin, Neutrophil, Heart

Publications for Allergic Bronchopulmonary Aspergillosis

Articles related to Allergic Bronchopulmonary Aspergillosis:

(show top 50) (show all 1685)
# Title Authors PMID Year
1
Clinical significance of decline in serum IgE levels in allergic bronchopulmonary aspergillosis. 54 61
19800210 2010
2
Identification and characterization of a laminin-binding protein of Aspergillus fumigatus: extracellular thaumatin domain protein (AfCalAp). 54 61
19429746 2009
3
Itraconazole, an effective adjunctive treatment for allergic bronchopulmonary aspergillosis. 54 61
19862941 2009
4
Treatment of allergic bronchopulmonary aspergillosis (ABPA) in CF with anti-IgE antibody (omalizumab). 54 61
19009619 2008
5
[Aspergillosis for the pulmonologist]. 54 61
19019289 2008
6
Partial correction of the CFTR-dependent ABPA mouse model with recombinant adeno-associated virus gene transfer of truncated CFTR gene. 54 61
18023072 2008
7
Distinct alleles of mannose-binding lectin (MBL) and surfactant proteins A (SP-A) in patients with chronic cavitary pulmonary aspergillosis and allergic bronchopulmonary aspergillosis. 54 61
17311505 2007
8
Elevated levels of mannan-binding lectin [corrected] (MBL) and eosinophilia in patients of bronchial asthma with allergic rhinitis and allergic bronchopulmonary aspergillosis associate with a novel intronic polymorphism in MBL. 54 61
16487239 2006
9
Allergic bronchopulmonary aspergillosis in a patient with cystic fibrosis: diagnostic criteria when the IgE level is less than 500 IU/mL. 54 61
16312174 2005
10
Time course of antibody response to recombinant Aspergillus fumigatus antigens in cystic fibrosis with and without ABPA. 54 61
15853950 2005
11
Role of collectins in innate immunity against aspergillosis. 54 61
16114131 2005
12
Aspergillus antigens: which are important? 54 61
16110811 2005
13
IgE antibody to Aspergillus fumigatus recombinant allergens in cystic fibrosis patients with allergic bronchopulmonary aspergillosis. 54 61
14763934 2004
14
Increased sensitivity to IL-4 in cystic fibrosis patients with allergic bronchopulmonary aspergillosis. 54 61
14674938 2004
15
[A case of pleural effusion associated with allergic bronchopulmonary aspergillosis during a relapse of the disease]. 54 61
14727554 2003
16
Surfactant protein D in serum from patients with allergic bronchopulmonary aspergillosis. 54 61
14582909 2003
17
Cystic fibrosis transmembrane conductance regulator gene mutations: do they play a role in the aetiology of allergic bronchopulmonary aspergillosis? 54 61
11994102 2002
18
Immunoglobulin-E and anti-IgE treatment in lung disease. 54 61
11980283 2001
19
The spectrum of CFTR-related disease. 54 61
11446679 2001
20
Frequency of cystic fibrosis transmembrane conductance regulator gene mutations and 5T allele in patients with allergic bronchopulmonary aspergillosis. 54 61
11243954 2001
21
'CFTR-opathies': disease phenotypes associated with cystic fibrosis transmembrane regulator gene mutations. 54 61
11737931 2001
22
Increased sensitivity to IL-4 in patients with allergic bronchopulmonary aspergillosis. 54 61
11146389 2000
23
[Hypereosinophilic reactions in hypersensitivity states]. 54 61
10808315 2000
24
Allergic bronchopulmonary aspergillosis in two patients with cystic fibrosis. 54 61
10731875 2000
25
[Successful treatment of allergic bronchopulmonary aspergillosis with erythromycin and fluconazole]. 54 61
10390974 1999
26
Allergic bronchopulmonary aspergillosis in cystic fibrosis: role of atopy and response to itraconazole. 54 61
10027433 1999
27
Immunological characterization of Asp f 2, a major allergen from Aspergillus fumigatus associated with allergic bronchopulmonary aspergillosis. 54 61
9784519 1998
28
[Allergic bronchopulmonary aspergillosis effectively treated with itraconazole]. 54 61
9866981 1998
29
[Two cases of Churg-Strauss syndrome with impaired prognosis]. 54 61
9745302 1998
30
IgE down regulation and cytokine induction by Aspergillus antigens in human allergic bronchopulmonary aspergillosis. 54 61
9523846 1998
31
Immunodominant peptide epitopes of allergen, Asp f 1 from the fungus Aspergillus fumigatus. 54 61
9864052 1998
32
Allergic bronchopulmonary aspergillosis with low serum IgE levels in a child with cystic fibrosis. 54 61
9314361 1997
33
Purification of a major allergen, Asp f 2 binding to IgE in allergic bronchopulmonary aspergillosis, from culture filtrate of Aspergillus fumigatus. 54 61
9215251 1997
34
Cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations in allergic bronchopulmonary aspergillosis. 54 61
8659542 1996
35
Improved diagnosis of allergic bronchopulmonary aspergillosis with gp66 (formerly antigen 7) of Aspergillus fumigatus for specific IgE detection. 54 61
8765818 1996
36
Cross-reactivity between Aspergillus fumigatus and Penicillium. 54 61
8645995 1996
37
Molecular cloning and expression of a recombinant Aspergillus fumigatus protein Asp f II with significant immunoglobulin E reactivity in allergic bronchopulmonary aspergillosis. 54 61
9273358 1996
38
Development of immune responses to Aspergillus at an early age in children with cystic fibrosis. 54 61
7952609 1994
39
IgE and eosinophil regulation in a murine model of allergic aspergillosis. 54 61
7964167 1994
40
Activated T cells and cytokines in bronchoalveolar lavages from patients with various lung diseases associated with eosinophilia. 54 61
7921434 1994
41
Rise in total IgE as an indicator of allergic bronchopulmonary aspergillosis in cystic fibrosis. 54 61
7974292 1994
42
Aspergillus ribotoxins react with IgE and IgG antibodies of patients with allergic bronchopulmonary aspergillosis. 54 61
8195680 1994
43
Recombinant expression and antigenic properties of a 32-kilodalton extracellular alkaline protease, representing a possible virulence factor from Aspergillus fumigatus. 54 61
8112866 1994
44
Hyperimmune serum modulates allergic response to spores in a murine model of allergic aspergillosis. 54 61
8283139 1994
45
Serum immunoglobulins E and G anti-Aspergillus fumigatus antibody in patients with cystic fibrosis who have allergic bronchopulmonary aspergillosis. 54 61
2230542 1990
46
T- and B-cell dysregulation of IgE synthesis in cystic fibrosis patients with allergic bronchopulmonary aspergillosis. 54 61
2137739 1990
47
Dupilumab treatment for allergic bronchopulmonary aspergillosis: A case series. 61
31811944 2020
48
Diagnostic Cutoffs and Clinical Utility of Recombinant Aspergillus fumigatus Antigens in the Diagnosis of Allergic Bronchopulmonary Aspergillosis. 61
31520840 2020
49
Allergic bronchopulmonary aspergillosis (ABPA) sans asthma: A distinct subset of ABPA with a lesser risk of exacerbation. 61
31111905 2020
50
The clinical characteristics and prognosis of ABPA are closely related to the mucus plugs in central bronchiectasis. 61
31758867 2020

Variations for Allergic Bronchopulmonary Aspergillosis

Expression for Allergic Bronchopulmonary Aspergillosis

Search GEO for disease gene expression data for Allergic Bronchopulmonary Aspergillosis.

Pathways for Allergic Bronchopulmonary Aspergillosis

Pathways related to Allergic Bronchopulmonary Aspergillosis according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.34 NPTN IL5 IL4 IL10 CCR3 CCL22
2
Show member pathways
13.28 IL5 IL4 IL10 IGHE IFNG HLA-DRB1
3
Show member pathways
13.18 NPTN IL5 IL4 IL10 FLNC CCR3
4
Show member pathways
12.75 IL5 IL4 IL10 IFNG HLA-DRB1 EPX
5
Show member pathways
12.57 IL4 IL10 IGHE IFNG HLA-DRB1
6
Show member pathways
12.51 IL5 IL4 IL10 IFNG HLA-DRB1
7
Show member pathways
12.27 IL5 IL4 IL10 IFNG
8
Show member pathways
12.26 IL10 CCR3 CCL22 CCL17
9
Show member pathways
12.23 IL5 IL4 IFNG CFTR CCL17
10
Show member pathways
12.19 IL4 IL10 IFNG HLA-DRB1
11
Show member pathways
12.07 SFTPD SFTPA1 IL4 IFNG CFTR
12 12.01 SFTPD SFTPA2 SFTPA1 MBL2 HLA-DRB1
13 11.91 IL4 IL10 IGHE CCL22
14 11.87 IL5 IL4 IL10 IFNG CCR3
15 11.83 IL5 IL4 HLA-DRB1
16 11.82 MBL2 IL10 HLA-DRB1
17
Show member pathways
11.8 SFTPD SFTPA2 SFTPA1
18 11.73 IL5 IL4 IFNG
19 11.69 SFTPA2 SFTPA1 IL10
20
Show member pathways
11.69 IL5 IL4 IFNG
21 11.68 IL5 IL4 IL10 IFNG
22 11.57 IL4 IL10 IFNG CCL22 CCL17
23 11.46 IL4 IL10 CCL22
24 11.45 SFTPA2 SFTPA1 IL5 IL4 CCR3
25
Show member pathways
11.43 SFTPD SFTPA2 SFTPA1
26
Show member pathways
11.39 SFTPD SFTPA2 SFTPA1
27 11.35 IL5 IL4 IL10 IGHE CCL17
28 11.26 IL5 IL4 IFNG
29 11.24 IL5 IL4 IFNG
30
Show member pathways
11.1 SFTPD SFTPA2 SFTPA1
31 11.08 IL5 IL4 IL10 IFNG
32 10.95 IL5 IL4 IL10 CCL22 CCL17
33 10.82 IL5 IL4 IL10 IFNG HLA-DRB1
34 10.76 IL5 IL4 IL10 IFNG CCL22 CCL17

GO Terms for Allergic Bronchopulmonary Aspergillosis

Cellular components related to Allergic Bronchopulmonary Aspergillosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 SFTPD SFTPA2 SFTPA1 MBL2 IL5 IL4
2 collagen trimer GO:0005581 9.46 SFTPD SFTPA2 SFTPA1 MBL2
3 extracellular region GO:0005576 9.44 SFTPD SFTPA2 SFTPA1 MBL2 IL5 IL4
4 clathrin-coated endocytic vesicle GO:0045334 9.43 SFTPD SFTPA2 SFTPA1
5 lamellar body GO:0042599 9.32 SFTPA2 SFTPA1

Biological processes related to Allergic Bronchopulmonary Aspergillosis according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.93 IL5 IL10 CCR3 CCL22 CCL17
2 chemokine-mediated signaling pathway GO:0070098 9.73 CCR3 CCL22 CCL17
3 cytokine-mediated signaling pathway GO:0019221 9.72 IL5 IL4 IL10 IGHE CCL22
4 positive regulation of phagocytosis GO:0050766 9.67 SFTPD MBL2 IFNG
5 negative regulation of T cell proliferation GO:0042130 9.65 SFTPD IL10 HLA-DRB1
6 defense response to bacterium GO:0042742 9.65 SFTPD MBL2 IL10 IGHE EPX
7 toll-like receptor signaling pathway GO:0002224 9.63 SFTPD SFTPA2 SFTPA1
8 negative regulation of cytokine production GO:0001818 9.58 NPTN IL10
9 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.57 IL4 IL10
10 opsonization GO:0008228 9.55 SFTPA1 MBL2
11 respiratory gaseous exchange GO:0007585 9.54 SFTPD SFTPA2 SFTPA1
12 neuroinflammatory response GO:0150076 9.52 IL4 IFNG
13 type 2 immune response GO:0042092 9.51 IL4 IL10
14 positive regulation of cellular respiration GO:1901857 9.43 IL4 IFNG
15 regulation of isotype switching GO:0045191 9.4 IL4 IL10
16 developmental process GO:0032502 9.33 SFTPD SFTPA2 SFTPA1
17 immune response GO:0006955 9.32 IL5 IL4 IL10 IGHE IFNG HLA-DRB1
18 positive regulation of MHC class II biosynthetic process GO:0045348 9.13 IL4 IL10 IFNG

Molecular functions related to Allergic Bronchopulmonary Aspergillosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carbohydrate binding GO:0030246 9.46 SFTPD SFTPA2 SFTPA1 MBL2
2 monosaccharide binding GO:0048029 9.13 SFTPD SFTPA2 SFTPA1
3 cytokine activity GO:0005125 9.1 IL5 IL4 IL10 IFNG CCL22 CCL17

Sources for Allergic Bronchopulmonary Aspergillosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
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