MCID: ALL008
MIFTS: 53

Allergic Bronchopulmonary Aspergillosis

Categories: Genetic diseases, Immune diseases, Infectious diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Allergic Bronchopulmonary Aspergillosis

MalaCards integrated aliases for Allergic Bronchopulmonary Aspergillosis:

Name: Allergic Bronchopulmonary Aspergillosis 12 77 54 15 17
Aspergillosis, Allergic Bronchopulmonary 54 45 74
Allergic Bronchopulmonary Mycosis 54 74
Aspergillosis Allergic Bronchopulmonary 56
Pulmonary Aspergillus Disease 12
Hinson-Pepys Disease 54
Abpa 54

Classifications:



Summaries for Allergic Bronchopulmonary Aspergillosis

NIH Rare Diseases : 54 Allergic bronchopulmonary aspergillosis is an allergic lung reaction to a type of fungus (Aspergillus fumigatus). Symptoms vary, but may include wheezing, bronchial hyperreactivity, hemoptysis, productive cough, low-grade fever, malaise, and weight loss. It is more common in people who have asthma or cystic fibrosis. The recommended treatment for allergic bronchopulmonary aspergillosis is itraconazole, a prescription antifungal medication. Oral corticosteroids, like prednisone, may also be helpful. The clinical course of allergic bronchopulmonary aspergillosis is variable. Many people with this condition can be stabilized for long periods when treated. However, only about 50% of patients achieve long-lasting remission and many require recurrent courses of treatment.

MalaCards based summary : Allergic Bronchopulmonary Aspergillosis, also known as aspergillosis, allergic bronchopulmonary, is related to aspergillosis and sinusitis. An important gene associated with Allergic Bronchopulmonary Aspergillosis is IL4 (Interleukin 4), and among its related pathways/superpathways are IL-17 Family Signaling Pathways and Bacterial infections in CF airways. The drugs Miconazole and Itraconazole have been mentioned in the context of this disorder. Affiliated tissues include lung, colon and testes, and related phenotypes are asthma and cough

Disease Ontology : 12 An aspergillosis that involves an allergic reaction due to the spores of Aspergillus moulds (A. fumigatus), which colonizes the mucus in the airways causing inflammation. The disease has symptom cough, has symptom wheezing and has symptom fever.

Wikipedia : 77 Allergic bronchopulmonary aspergillosis (ABPA) is a condition characterised by an exaggerated response... more...

Related Diseases for Allergic Bronchopulmonary Aspergillosis

Diseases in the Allergic Bronchopulmonary Aspergillosis family:

Allergic Bronchopulmonary Aspergillosis, Familial

Diseases related to Allergic Bronchopulmonary Aspergillosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
# Related Disease Score Top Affiliating Genes
1 aspergillosis 32.0 CCL17 CFTR IL4 IL5 MBL2 SFTPA2
2 sinusitis 31.2 CFTR IL5
3 cystic fibrosis 31.0 CFTR MBL2 SFTPD
4 asthma 30.7 CCL17 CFTR EPX IL4 IL5
5 ige responsiveness, atopic 30.7 IL4 IL5
6 churg-strauss syndrome 30.6 CCL17 IL5
7 pneumonia 30.6 IL5 MBL2 SFTPD
8 cough variant asthma 30.6 IL4 IL5
9 rhinitis 30.5 EPX IL4 IL5
10 dermatitis 30.5 CCL17 IL4 IL5
11 allergic rhinitis 30.4 EPX IL4 IL5
12 eosinophilic gastroenteritis 30.4 EPX IL5
13 eosinophilic pneumonia 30.2 CCL17 IL5 SFTPD
14 hypereosinophilic syndrome 30.2 CCL17 EPX IL4 IL5
15 invasive aspergillosis 30.2 MBL2 SFTPD
16 dermatitis, atopic 30.1 CCL17 EPX IL4 IL5
17 allergic hypersensitivity disease 29.9 CCL17 EPX IL4 IL5
18 pulmonary eosinophilia 29.3 CCL17 EPX IL4 IL5 SFTPD
19 lung disease 29.3 CFTR IL5 MBL2 SFTPA1 SFTPA2 SFTPD
20 allergic bronchopulmonary aspergillosis, familial 12.7
21 plastic bronchitis 11.5
22 bronchiectasis 10.6
23 pulmonary tuberculosis 10.5
24 eosinophilic granulomatosis with polyangiitis 10.5
25 granulomatosis with polyangiitis 10.4
26 middle lobe syndrome 10.4
27 nickel allergic contact dermatitis 10.3 IL4 IL5
28 scleritis 10.3 IL4 IL5
29 egg allergy 10.3 IL4 IL5
30 sulfamethoxazole allergy 10.3 IL4 IL5
31 atopic keratoconjunctivitis 10.3 IL4 IL5
32 angiostrongyliasis 10.3 IL4 IL5
33 intrinsic asthma 10.3 IL4 IL5
34 trichinosis 10.3 IL4 IL5
35 gaucher disease, type ii 10.3 IL4 IL5
36 non-suppurative otitis media 10.3 IL4 IL5
37 latex allergy 10.3 IL4 IL5
38 eosinophilic meningitis 10.3 IL4 IL5
39 pneumothorax 10.3
40 intestinal schistosomiasis 10.3 IL4 IL5
41 chronic tic disorder 10.3 IL4 IL5
42 filarial elephantiasis 10.3 IL4 IL5
43 vulvovaginal candidiasis 10.3 IL4 MBL2
44 chronic conjunctivitis 10.3 IL4 IL5
45 eosinophilic gastritis 10.3 IL4 IL5
46 kimura disease 10.3 IL4 IL5
47 vernal keratoconjunctivitis 10.3 IL4 IL5
48 toxic oil syndrome 10.3 IL4 IL5
49 folliculitis 10.3 IL4 IL5
50 enterobiasis 10.3 IL4 IL5

Graphical network of the top 20 diseases related to Allergic Bronchopulmonary Aspergillosis:



Diseases related to Allergic Bronchopulmonary Aspergillosis

Symptoms & Phenotypes for Allergic Bronchopulmonary Aspergillosis

Human phenotypes related to Allergic Bronchopulmonary Aspergillosis:

33 (show all 12)
# Description HPO Frequency HPO Source Accession
1 asthma 33 hallmark (90%) HP:0002099
2 cough 33 hallmark (90%) HP:0012735
3 abnormal eosinophil morphology 33 hallmark (90%) HP:0001879
4 weight loss 33 frequent (33%) HP:0001824
5 cerebral cortical atrophy 33 frequent (33%) HP:0002120
6 bronchiectasis 33 frequent (33%) HP:0002110
7 low-grade fever 33 frequent (33%) HP:0011134
8 respiratory insufficiency 33 occasional (7.5%) HP:0002093
9 emphysema 33 occasional (7.5%) HP:0002097
10 pulmonary arterial hypertension 33 occasional (7.5%) HP:0002092
11 hemoptysis 33 occasional (7.5%) HP:0002105
12 abnormal fingernail morphology 33 occasional (7.5%) HP:0001231

MGI Mouse Phenotypes related to Allergic Bronchopulmonary Aspergillosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.76 CCL17 CFTR EPX IL4 IL5 MBL2
2 immune system MP:0005387 9.56 CCL17 CFTR EPX IL4 IL5 MBL2
3 respiratory system MP:0005388 9.02 CFTR IL4 IL5 SFTPA1 SFTPD

Drugs & Therapeutics for Allergic Bronchopulmonary Aspergillosis

Drugs for Allergic Bronchopulmonary Aspergillosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 69)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 22916-47-8 4189
2
Itraconazole Approved, Investigational Phase 4,Phase 2,Phase 3 84625-61-6 55283
3
Omalizumab Approved, Investigational Phase 4 242138-07-4
4 Hormones Phase 4,Phase 2,Phase 3,Not Applicable
5 Immunoglobulins Phase 4
6 Hormone Antagonists Phase 4,Phase 2,Phase 3
7 Immunoglobulin E Phase 4
8 Steroid Synthesis Inhibitors Phase 4,Phase 2,Phase 3
9 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 2,Phase 3
10 Respiratory System Agents Phase 4,Phase 2,Phase 3
11 Antibodies Phase 4
12 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 2,Phase 3
13
Hydroxyitraconazole Phase 4,Phase 2,Phase 3
14 Anti-Allergic Agents Phase 4,Phase 2,Phase 3
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3
16 Antifungal Agents Phase 4,Phase 2,Phase 3
17 Anti-Asthmatic Agents Phase 4,Phase 2,Phase 3
18 Anti-Infective Agents Phase 4,Phase 2,Phase 3
19
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3,Phase 3 83-43-2 6741
20
Prednisolone Approved, Vet_approved Phase 2, Phase 3,Phase 3 50-24-8 5755
21
Prednisolone phosphate Approved, Vet_approved Phase 2, Phase 3,Phase 3 302-25-0
22
Methylprednisolone hemisuccinate Approved Phase 2, Phase 3,Phase 3 2921-57-5
23
Voriconazole Approved, Investigational Phase 2, Phase 3 137234-62-9 71616
24
Fluticasone Approved, Experimental Phase 2, Phase 3,Phase 3 90566-53-3 62924
25
Budesonide Approved Phase 2, Phase 3 51333-22-3 5281004 63006
26
deoxycholic acid Approved Phase 2, Phase 3 83-44-3 222528
27
Amphotericin B Approved, Investigational Phase 2, Phase 3 1397-89-3 5280965 14956
28
Vitamin D3 Approved, Nutraceutical Phase 2, Phase 3,Phase 3,Not Applicable 67-97-0 5280795 6221
29
Vitamin D Approved, Nutraceutical, Vet_approved Phase 2, Phase 3,Not Applicable 1406-16-2
30
Calcium Approved, Nutraceutical Phase 2, Phase 3,Not Applicable 7440-70-2 271
31
Ergocalciferol Approved, Nutraceutical Phase 2, Phase 3,Not Applicable 50-14-6 5280793
32
Prednisolone hemisuccinate Experimental Phase 2, Phase 3,Phase 3 2920-86-7
33 Methylprednisolone Acetate Phase 2, Phase 3,Phase 3
34 glucocorticoids Phase 2, Phase 3,Phase 3
35 Prednisolone acetate Phase 2, Phase 3,Phase 3
36 Autonomic Agents Phase 2, Phase 3,Phase 3
37 Gastrointestinal Agents Phase 2, Phase 3,Phase 3
38 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 3
39 Antiemetics Phase 2, Phase 3,Phase 3
40 Antineoplastic Agents, Hormonal Phase 2, Phase 3,Phase 3
41 Formoterol Fumarate Phase 2, Phase 3,Phase 3
42 Protective Agents Phase 2, Phase 3,Phase 3
43 Neuroprotective Agents Phase 2, Phase 3,Phase 3
44 Anti-Inflammatory Agents Phase 2, Phase 3,Phase 3
45 Ergocalciferols Phase 2, Phase 3,Not Applicable
46 Bone Density Conservation Agents Phase 2, Phase 3,Not Applicable
47 Vitamin D2 Phase 2, Phase 3,Not Applicable
48 Micronutrients Phase 2, Phase 3,Not Applicable
49 Calcium, Dietary Phase 2, Phase 3,Not Applicable
50 Nutrients Phase 2, Phase 3,Not Applicable

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 An Exploratory Study to Assess Multiple Doses of Omalizumab in Patients With Cystic Fibrosis Complicated by Acute Bronchopulmonary Aspergillosis (ABPA) Terminated NCT00787917 Phase 4 Omalizumab;Placebo;Itraconazole
2 Trial on the Efficacy and Safety of Two Different Glucocorticoid Dose Regimens in Allergic Bronchopulmonary Aspergillosis Completed NCT00974766 Phase 2, Phase 3 Glucocorticoids;Glucocorticoids
3 Voriconazole Versus Oral Steroids in Allergic Bronchopulmonary Aspergillosis Completed NCT01621321 Phase 2, Phase 3 Prednisolone;Voriconazole
4 A Study Evaluating Vitamin D in Allergic Bronchopulmonary Aspergillosis Complicating Asthma Completed NCT03133299 Phase 2, Phase 3 Glucocorticoids;Vitamin D
5 A Randomized Controlled Trial of Inhaled Amphotericin B for Maintaining Remission in Allergic Bronchopulmonary Aspergillosis Completed NCT01857479 Phase 2, Phase 3 Inhaled budesonide;Inhaled amphotericin
6 Monotherapy of Itraconazole Versus Prednisolone in Allergic Bronchopulmonary Aspergillosis Completed NCT01321827 Phase 2, Phase 3 Glucocorticoids;Itraconazole
7 A Randomized Trial of Itraconazole in Acute Stages of Allergic Bronchopulmonary Aspergillosis Recruiting NCT02440009 Phase 2, Phase 3 Itraconazole;Glucocorticoids
8 Evaluation of a Therapeutic Strategy Including Nebulised Liposomal Amphotericin B (Ambisome®) in Maintenance Treatment of Allergic Bronchopulmonary Aspergillosis (Cystic Fibrosis Excluded). Active, not recruiting NCT02273661 Phase 2 Liposomal amphotericin B (Ambisome®);placebo
9 Study in Adult Asthmatic Patients With Allergic Bronchopulmonary Aspergillosis Not yet recruiting NCT03960606 Phase 2
10 Safety, Tolerability, Pharmacokinetics, and Preliminary Pharmacodynamics of QBW251 in Healthy Subjects and Cystic Fibrosis Patients Terminated NCT02190604 Phase 1, Phase 2 Placebo;QBW251
11 Lung MRI and Allergic Broncho-pulmonary Aspergillosis in Cystic Fibrosis Completed NCT02853175
12 Mechanisms of Immune Tolerance and Inflammation in Patients With Cystic Fibrosis With ABPA Completed NCT00585364
13 Protocol TARC-ABPA Completed NCT01710930 Not Applicable
14 Open-label Vitamin D Trial for Patients With Cystic Fibrosis and Allergic Bronchopulmonary Aspergillosis Completed NCT01222273 Not Applicable
15 Evaluation of Bronchial Inflammation in Allergic Bronchopulmonary Aspergillosis (ABPA) Completed NCT00906568
16 Duplication in CHIT1 Gene and the Risk for Aspergillus Lung Disease in CF Patients Completed NCT01572870
17 Estimated Impact of Fungal Colonization in Cystic Fibrosis From Secondary Exploitation of MucoFong Database. Completed NCT03753828
18 Cytokine Profile of Allergic Bronchopulmonary Aspergillosis Recruiting NCT03643185
19 Natural History of Bronchiectasis Recruiting NCT00943514
20 Observational Study of Characteristics, Treatment and Outcomes With Severe Asthma in the United States (CHRONICLE) Recruiting NCT03373045
21 MR Imaging of Lung in the Follow-up Assessment of Cystic Fibrosis Recruiting NCT03357562 Not Applicable
22 Diagnostic Value of MRI for Allergic Broncho-Pulmonary Aspergilloses Not yet recruiting NCT03265366 Not Applicable
23 Role of Thymus-And Activation-Regulated Chemokine (TARC) In Diagnosis Of Allergic Bronchopulmonary Aspergillosis Not yet recruiting NCT03267394
24 Analysis T Cells Response for Identification of Aspergillus Bronchitis With Cystic Fibrosis Patients Terminated NCT02550041 Not Applicable

Search NIH Clinical Center for Allergic Bronchopulmonary Aspergillosis

Cochrane evidence based reviews: aspergillosis, allergic bronchopulmonary

Genetic Tests for Allergic Bronchopulmonary Aspergillosis

Anatomical Context for Allergic Bronchopulmonary Aspergillosis

MalaCards organs/tissues related to Allergic Bronchopulmonary Aspergillosis:

42
Lung, Colon, Testes, T Cells, Skin, Thymus, Bone

Publications for Allergic Bronchopulmonary Aspergillosis

Articles related to Allergic Bronchopulmonary Aspergillosis:

(show top 50) (show all 745)
# Title Authors Year
1
Allergic bronchopulmonary aspergillosis (ABPA) sans asthma: A distinct subset of ABPA with a lesser risk of exacerbation. ( 31111905 )
2019
2
A new IgE Western blot identifies Aspergillus fumigatus sensitization and may discriminate allergic bronchopulmonary aspergillosis. ( 31004499 )
2019
3
Serological analysis of sensitization in allergic bronchopulmonary aspergillosis: a study on allergen components and interspecies relationships. ( 30943819 )
2019
4
Nonsystemic allergic bronchopulmonary aspergillosis in cystic fibrosis: A suggested paradigm for the evolution from topical to systemic disease. ( 30938080 )
2019
5
Posaconazole for the treatment of allergic bronchopulmonary aspergillosis in patients with cystic fibrosis. ( 30805605 )
2019
6
Chronic pulmonary aspergillosis may cause eosinophilic granulomatosis with polyangiitis via allergic bronchopulmonary aspergillosis. ( 30800324 )
2019
7
Successful control of exacerbation of Allergic Bronchopulmonary Aspergillosis due to Aspergillus terreus in a cystic fibrosis patient with short-term adjunctive therapy with voriconazole: A case report. ( 30782501 )
2019
8
Successful treatment with omalizumab of allergic bronchopulmonary aspergillosis in patients with cystic fibrosis: case reports and literature review. ( 30772479 )
2019
9
Allergic bronchopulmonary aspergillosis presumably unmasked by PD-1 inhibition. ( 30765445 )
2019
10
Prevalence of sensitization to Aspergillus flavus in patients with allergic bronchopulmonary aspergillosis. ( 29566248 )
2019
11
Intravenous immunoglobulin protects from experimental allergic bronchopulmonary aspergillosis via a sialylation-dependent mechanism. ( 30267564 )
2019
12
Late-onset allergic bronchopulmonary aspergillosis (ABPA). ( 30496509 )
2019
13
Allergic bronchopulmonary aspergillosis successfully treated with mepolizumab: Case report and review of the literature. ( 30533379 )
2019
14
Voriconazole hepatotoxicity as a result of steroid withdrawal in a patient with allergic bronchopulmonary aspergillosis. ( 30537018 )
2019
15
Role of Aspergillus fumigatus-Specific IgE in the Diagnosis of Allergic Bronchopulmonary Aspergillosis. ( 30625471 )
2019
16
Allergic bronchopulmonary aspergillosis screening in bronchiectasis: is there always a precise answer to a clear question? ( 30638358 )
2019
17
Allergic bronchopulmonary aspergillosis in succession to chronic eosinophilic pneumonia. ( 30670338 )
2019
18
Pulmonary infection caused by Nocardia cyriacigeorgica in a patient with allergic bronchopulmonary aspergillosis: A case report: Erratum. ( 30681635 )
2019
19
Evaluation of 3 T lung magnetic resonance imaging in children with allergic bronchopulmonary aspergillosis: Pilot study. ( 30691671 )
2019
20
Case series of allergic bronchopulmonary aspergillosis treated successfully and safely with long-term mepolizumab. ( 30704844 )
2019
21
Prevalence of allergic bronchopulmonary aspergillosis among patients with severe bronchial asthma in a tertiary care hospital in Northern India. ( 30706871 )
2019
22
CT evaluation of hyperattenuating mucus to diagnose allergic bronchopulmonary aspergillosis in the special condition of cystic fibrosis. ( 30765182 )
2019
23
Allergic bronchopulmonary aspergillosis in Japan: A nationwide survey. ( 28546015 )
2018
24
Mucus plugging in allergic bronchopulmonary aspergillosis: Implication of the eosinophil DNA traps. ( 28886913 )
2018
25
F508del CFTR gene mutation in patients with allergic bronchopulmonary aspergillosis. ( 29035608 )
2018
26
Vitamin D levels in asthmatic patients with and without allergic bronchopulmonary aspergillosis. ( 29314357 )
2018
27
A Randomized Trial of Itraconazole vs Prednisolone in Acute-Stage Allergic Bronchopulmonary Aspergillosis Complicating Asthma. ( 29331473 )
2018
28
A case of allergic bronchopulmonary aspergillosis in a 43-year-old farmer following single high level exposure to organic dust with symptomatic remission and radiological resolution after early diagnosis and treatment. ( 29479448 )
2018
29
Mutations in EEA1 are associated with allergic bronchopulmonary aspergillosis and affect phagocytosis of Aspergillus fumigatus by human macrophages. ( 29547649 )
2018
30
Asthma and Fungus: Role in Allergic Bronchopulmonary Aspergillosis (ABPA) and Other Conditions. ( 29549557 )
2018
31
Anti-IgE therapy for allergic bronchopulmonary aspergillosis in people with cystic fibrosis. ( 29551015 )
2018
32
A case of allergic bronchopulmonary aspergillosis successfully treated with mepolizumab. ( 29587693 )
2018
33
Allergic bronchopulmonary aspergillosis in patients with cystic fibrosis and non-cystic fibrosis bronchiectasis. ( 29588830 )
2018
34
Severe asthma concomitant with allergic bronchopulmonary aspergillosis successfully treated with mepolizumab. ( 29665990 )
2018
35
Clinical Characteristics of Fifty Patients with Allergic Bronchopulmonary Aspergillosis. ( 29692383 )
2018
36
Concordance between Aspergillus-specific precipitating antibody and IgG in allergic bronchopulmonary aspergillosis. ( 29773475 )
2018
37
Mycobacterium avium intracellulare infection complicated by allergic bronchopulmonary aspergillosis in a non-asthmatic patient. ( 29804082 )
2018
38
National Jewish Health classical pulmonary radiology case reports: imaging features of allergic bronchopulmonary aspergillosis. ( 29878247 )
2018
39
"Fleeting pulmonary infiltrates in allergic bronchopulmonary aspergillosis" Misdiagnosed as tuberculosis. ( 29900899 )
2018
40
Utility of recombinant Aspergillus fumigatus antigens in the diagnosis of allergic bronchopulmonary aspergillosis: A systematic review and diagnostic test accuracy meta-analysis. ( 29927507 )
2018
41
Omalizumab in allergic bronchopulmonary aspergillosis in patients with cystic fibrosis. ( 29950869 )
2018
42
Allergic bronchopulmonary aspergillosis presenting as nephrotic syndrome due to secondary amyloidosis: Case report and systematic review of the literature. ( 29970774 )
2018
43
Risk factors and impact of allergic bronchopulmonary aspergillosis in Pseudomonas aeruginosa-negative CF patients. ( 29981532 )
2018
44
A randomised trial of voriconazole and prednisolone monotherapy in acute-stage allergic bronchopulmonary aspergillosis complicating asthma. ( 30049743 )
2018
45
Allergic Bronchopulmonary Aspergillosis. ( 30140508 )
2018
46
Radioaerosol Imaging Predicts the Utility of Aerosolized Antifungal Therapy in Allergic Bronchopulmonary Aspergillosis. ( 30199380 )
2018
47
Erratum: Omalizumab in allergic bronchopulmonary aspergillosis in patients with cystic fibrosis [Erratum]. ( 30254475 )
2018
48
Allergic Bronchopulmonary Aspergillosis-A Luminal Hypereosinophilic Disease With Extracellular Trap Cell Death. ( 30364279 )
2018
49
Childhood allergic bronchopulmonary aspergillosis. ( 30381560 )
2018
50
Pulmonary infection caused by Nocardia cyriacigeorgica in a patient with allergic bronchopulmonary aspergillosis: A case report. ( 30412142 )
2018

Variations for Allergic Bronchopulmonary Aspergillosis

Expression for Allergic Bronchopulmonary Aspergillosis

Search GEO for disease gene expression data for Allergic Bronchopulmonary Aspergillosis.

Pathways for Allergic Bronchopulmonary Aspergillosis

Pathways related to Allergic Bronchopulmonary Aspergillosis according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.07 CCL17 CFTR IL4 IL5
2
Show member pathways
11.78 CFTR IL4 SFTPA1 SFTPD
3 11.64 MBL2 SFTPA1 SFTPA2 SFTPD
4
Show member pathways
11.62 SFTPA1 SFTPA2 SFTPD
5 11.43 CCL17 IL4 IL5
6
Show member pathways
11.24 SFTPA1 SFTPA2 SFTPD
7 11.21 CCL17 IL4 IL5
8
Show member pathways
11.13 SFTPA1 SFTPA2 SFTPD
9 11.07 IL4 IL5
10 11.04 IL4 IL5
11 10.99 IL4 IL5
12 10.93 IL4 IL5
13 10.9 CCL17 IL4 IL5
14 10.72 IL4 IL5 SFTPA1 SFTPA2
15
Show member pathways
10.53 SFTPA1 SFTPA2 SFTPD

GO Terms for Allergic Bronchopulmonary Aspergillosis

Cellular components related to Allergic Bronchopulmonary Aspergillosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.92 CCL17 EPX IL4 IL5 MBL2 SFTPA1
2 rough endoplasmic reticulum GO:0005791 9.54 SFTPA1 SFTPA2 SFTPD
3 multivesicular body GO:0005771 9.43 SFTPA1 SFTPA2 SFTPD
4 lamellar body GO:0042599 9.4 SFTPA1 SFTPA2
5 clathrin-coated endocytic vesicle GO:0045334 9.33 SFTPA1 SFTPA2 SFTPD
6 collagen trimer GO:0005581 9.26 MBL2 SFTPA1 SFTPA2 SFTPD
7 extracellular space GO:0005615 9.23 CCL17 EPX IL4 IL5 MBL2 SFTPA1

Biological processes related to Allergic Bronchopulmonary Aspergillosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.58 EPX MBL2 SFTPD
2 cellular protein metabolic process GO:0044267 9.54 SFTPA1 SFTPA2 SFTPD
3 positive regulation of B cell proliferation GO:0030890 9.43 IL4 IL5
4 toll-like receptor signaling pathway GO:0002224 9.43 SFTPA1 SFTPA2 SFTPD
5 respiratory gaseous exchange GO:0007585 9.33 SFTPA1 SFTPA2 SFTPD
6 opsonization GO:0008228 9.32 MBL2 SFTPA1
7 surfactant homeostasis GO:0043129 9.13 SFTPA1 SFTPA2 SFTPD
8 positive regulation of phagocytosis GO:0050766 8.92 MBL2 SFTPA1 SFTPA2 SFTPD

Molecular functions related to Allergic Bronchopulmonary Aspergillosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carbohydrate binding GO:0030246 9.46 MBL2 SFTPA1 SFTPA2 SFTPD
2 cytokine activity GO:0005125 9.43 CCL17 IL4 IL5
3 lipopolysaccharide binding GO:0001530 9.13 SFTPA1 SFTPA2 SFTPD
4 monosaccharide binding GO:0048029 8.8 SFTPA1 SFTPA2 SFTPD

Sources for Allergic Bronchopulmonary Aspergillosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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