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MCID: ALL010
MIFTS: 61

Allergic Contact Dermatitis

Categories: Immune diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Allergic Contact Dermatitis

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MalaCards integrated aliases for Allergic Contact Dermatitis:

Name: Allergic Contact Dermatitis 12 38 15 17 64
Dermatitis, Allergic Contact 45 74
Contact Dermatitis, Allergic 77
Dermatitis Allergic Contact 56

Classifications:

MalaCards categories:
Anatomical: Skin diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:3042
KEGG 38 H01357
MeSH 45 D017449
NCIt 51 C26998
UMLS 74 C0162820
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Summaries for Allergic Contact Dermatitis

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PubMed Health : 64 About allergic contact dermatitis: A number of chemical or herbal substances can irritate the skin. Redness, burning or itching are normal skin reactions, for instance, to aggressive cleaning agents.Allergic contact dermatitis (sometimes simply called “contact allergies”) is different, though. Here the immune system overreacts to certain substances – sometimes to very small amounts – that normally wouldn’t cause a reaction. Common examples include certain metals, scents and latex rubber.Contact allergies can lead to severe skin reactions. Unlike with many other kinds of allergies, the reaction doesn’t occur immediately, but after one to three days. And contact allergies develop gradually over a long period of time, as a result of repeated contact with the substance that triggers them. Some people are then no longer able to carry on doing the same kind of work as before.

MalaCards based summary : Allergic Contact Dermatitis, also known as dermatitis, allergic contact, is related to 1,4-phenylenediamine allergic contact dermatitis and palladium allergic contact dermatitis. An important gene associated with Allergic Contact Dermatitis is IL31 (Interleukin 31), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Bacitracin and Hydrocortisone acetate have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and t cells, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Disease Ontology : 12 A contact dermititis that is an allergic skin reaction to foreign chemical or substances leading to red, itchy, weepy reaction where the skin has come into contact with a substance that the immune system recognizes as foreign.

Wikipedia : 77 Allergic contact dermatitis (ACD) is a form of contact dermatitis that is the manifestation of an... more...

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Related Diseases for Allergic Contact Dermatitis

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Diseases related to Allergic Contact Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 408)
# Related Disease Score Top Affiliating Genes
1 1,4-phenylenediamine allergic contact dermatitis 34.8 NAT2 TNF
2 palladium allergic contact dermatitis 34.1 CCL17 IL10 IL17A
3 nickel allergic contact dermatitis 34.1 IFNG IL10 IL4 IL5
4 toxicodendron dermatitis 32.4 CXCL8 ICAM1
5 dermatitis 31.4 CCL17 FLG IFNG IL17A IL31 IL4
6 mycosis fungoides 30.9 CCL17 CXCR3 IL5
7 alopecia areata 30.8 ICAM1 IFNG TNF
8 erythema multiforme 30.7 CCL17 CXCR3 ICAM1 IFNG TNF
9 scabies 30.6 CXCL8 IL10
10 acute generalized exanthematous pustulosis 30.5 CXCL8 IL17A
11 hypereosinophilic syndrome 30.3 CCL17 IL4 IL5
12 ige responsiveness, atopic 30.1 IFNG IL10 IL4 IL5
13 cutaneous t cell lymphoma 30.0 CCL17 IFNG IL4
14 discoid lupus erythematosus 30.0 FLG IL10 NAT2
15 irritant dermatitis 29.8 FLG IL1B TNF
16 esophagitis 29.8 CXCL8 IL1B IL5
17 actinic prurigo 29.7 ICAM1 IL1B SELE TNF
18 allergic hypersensitivity disease 29.7 CCL17 IFNG IL10 IL4 IL5
19 conjunctivitis 29.6 CXCL8 ICAM1 IFNG IL33 IL4 IL5
20 contact dermatitis 29.4 CCL17 CXCL8 CXCR3 FLG ICAM1 IFNG
21 lichen planus 29.4 CXCR3 FLG ICAM1 IFNG IL4 TNF
22 sleep apnea 29.4 CXCL8 ICAM1 IL1B TNF
23 osteomyelitis 29.1 CXCL8 IFNG IL10 IL1B TNF
24 arthritis 28.8 CXCL8 IFNG IL10 IL17A IL1B TNF
25 dermatitis, atopic 28.6 CCL17 CXCL8 FLG ICAM1 IFNG IL10
26 skin disease 27.6 CCL17 CXCL8 FLG ICAM1 IFNG IL10
27 asthma 27.3 CCL17 CXCL8 FLG ICAM1 IFNG IL10
28 chromium allergic contact dermatitis 12.8
29 1-chloro-2,4-dinitrobenzene allergic contact dermatitis 12.8
30 cobalt allergic contact dermatitis 12.7
31 4-tert-butylphenol allergic contact dermatitis 12.7
32 benzo[d]isothiazol-3-one allergic contact dermatitis 12.7
33 diphenylmethane-4,4'-diisocyanate allergic contact dermatitis 12.6
34 benzoic acid allergic contact dermatitis 12.6
35 carvone allergic contact dermatitis 12.6
36 neomycin sulfate allergic contact dermatitis 12.6
37 parthenolide allergic contact dermatitis 12.6
38 formaldehyde allergic contact dermatitis 12.6
39 2,4-dinitrophenyl allergic contact dermatitis 12.6
40 potassium dichromate allergic contact dermatitis 12.6
41 n,n'-diphenylthiourea allergic contact dermatitis 12.6
42 n,n'-diethylthiourea allergic contact dermatitis 12.6
43 allergic contact dermatitis of eyelid 12.4
44 occupational dermatitis 11.7
45 photoallergic dermatitis 11.4
46 psoriasis 10.6
47 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 IL5 TNF
48 urticaria 10.5
49 critical limb ischemia 10.5 SELE TNF
50 mooren's ulcer 10.5 ICAM1 SELE

Graphical network of the top 20 diseases related to Allergic Contact Dermatitis:



Diseases related to Allergic Contact Dermatitis
Sources

Symptoms & Phenotypes for Allergic Contact Dermatitis

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GenomeRNAi Phenotypes related to Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.7 CXCL8 ICAM1 IL10 IL17A IL1B TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.7 CXCL8 ICAM1 IL10 IL17A IL1B TNF

MGI Mouse Phenotypes related to Allergic Contact Dermatitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.15 CCL17 CXCR3 ICAM1 IFNG IL10 IL17A
2 homeostasis/metabolism MP:0005376 10.1 CXCR3 ICAM1 IFNG IL10 IL17A IL1B
3 immune system MP:0005387 10.03 CCL17 CXCR3 ICAM1 IFNG IL10 IL17A
4 digestive/alimentary MP:0005381 10.01 ICAM1 IFNG IL10 IL17A IL33 IL4
5 craniofacial MP:0005382 9.91 IFNG IL10 IL17A IL1B IL4 TNF
6 integument MP:0010771 9.76 ICAM1 IFNG IL10 IL1B IL33 IL4
7 neoplasm MP:0002006 9.5 CXCR3 ICAM1 IFNG IL10 IL1B IL5
8 respiratory system MP:0005388 9.28 CXCR3 IFNG IL10 IL17A IL33 IL4
Sources

Drugs & Therapeutics for Allergic Contact Dermatitis

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PubMedHealth treatment related to Allergic Contact Dermatitis: 64

Allergic skin reactions are usually treated with steroid creams, ointments or solutions.But the main thing to do is avoid contact with the substance that triggers the reaction. Protective gloves and clothing can help here, for instance.A change of career may have to be considered if it isn’t possible to avoid contact with the substance in the workplace. If you are believed to have a work-related contact allergy, it’s a good idea to have your doctor inform your employer’s liability insurance. The insurance will cover certain costs, like the costs of protective measures, if the allergy is recognized as being work-related.

Drugs for Allergic Contact Dermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 117)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bacitracin Approved, Vet_approved Phase 4,Phase 2 1405-87-4 439542 10909430
2
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
3
Bronopol Approved Phase 4 52-51-7
4
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
5 Parthenolide Approved, Investigational Phase 4,Phase 2 20554-84-1
6
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492 6473866
7
Povidone Approved Phase 4 9003-39-8
8
Benzoyl peroxide Approved Phase 4 94-36-0 7187
9
Adapalene Approved Phase 4 106685-40-9 60164
10
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
11 Anti-Infective Agents, Local Phase 4,Phase 3,Phase 2
12 Antioxidants Phase 4
13 Hydrocortisone 17-butyrate 21-propionate Phase 4
14 Hydrocortisone-17-butyrate Phase 4
15 Peripheral Nervous System Agents Phase 4,Phase 2,Not Applicable
16 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable
17 Antidotes Phase 4
18 Anti-Inflammatory Agents Phase 4,Phase 2,Not Applicable
19 Anti-Infective Agents Phase 4,Phase 3,Phase 2
20 Gold Sodium Thiosulfate Phase 4
21 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Not Applicable
22 Chelating Agents Phase 4
23 sodium thiosulfate Phase 4
24 Antitubercular Agents Phase 4
25 Analgesics Phase 4,Phase 2,Not Applicable
26 Hydrocortisone hemisuccinate Phase 4
27 Dermatologic Agents Phase 4,Phase 3,Phase 1,Not Applicable
28 Antirheumatic Agents Phase 4,Phase 2,Not Applicable
29 Analgesics, Non-Narcotic Phase 4,Phase 2,Not Applicable
30 Protective Agents Phase 4,Not Applicable
31 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1
32 Calcineurin Inhibitors Phase 4
33 Immunosuppressive Agents Phase 4,Phase 2
34 Adapalene, Benzoyl Peroxide Drug Combination Phase 4
35 Clindamycin phosphate Phase 4
36 Clindamycin palmitate Phase 4
37
Timolol Approved Phase 3 26839-75-8 33624 5478
38
Petrolatum Approved, Investigational Phase 3,Not Applicable 8009-03-8
39
Sulfadiazine Approved, Investigational, Vet_approved Phase 3 68-35-9 5215
40
Silver sulfadiazine Approved, Vet_approved Phase 3 22199-08-2 441244
41
SB-649868 Experimental, Investigational Phase 3 110-16-7, 110-17-8 444972
42 Antibodies, Monoclonal Phase 3,Phase 1
43 Immunoglobulins Phase 3,Phase 1
44 Antibodies Phase 3,Phase 1
45 Adrenergic Agents Phase 3
46 Pharmaceutical Solutions Phase 3,Phase 1,Phase 2,Not Applicable
47 Antihypertensive Agents Phase 3,Phase 1,Phase 2
48 Adrenergic Antagonists Phase 3
49 Adrenergic beta-Antagonists Phase 3
50 Anti-Arrhythmia Agents Phase 3

Interventional clinical trials:

(show top 50) (show all 59)
# Name Status NCT ID Phase Drugs
1 Clinical Evaluation of T.R.U.E. Test Allergens in Children an Adolescents Unknown status NCT01797562 Phase 4 T.R.U.E. Test Panel 3.2
2 Quaternium-15, Use Test Unknown status NCT00311454 Phase 4 T.R.U.E.Test
3 Study of the Safety and Efficacy of Tacrolimus Ointment in Treating Chronic Allergic Contact Dermatitis Completed NCT00667056 Phase 4 tacrolimus ointment;placebo ointment
4 Bioequivalence of Ethylenediamine Dihydrochloride Study Completed NCT01798589 Phase 4 Ethylenediamine dihydrochloride
5 A Comparative Study of the Tolerability of Two Combination Therapies for the Treatment of Acne Completed NCT00887484 Phase 4 BENZOYL PEROXIDE/ CLINDAMYCIN;BENZOYL PEROXIDE/ ADAPALENE
6 A Study to Evaluate Tolerability of Two Topical Drug Products in the Treatment of Facial Acne Completed NCT00964223 Phase 4 Clindamycin and benzoyl peroxide gel (Duac® Topical Gel);benzoyl peroxide and adapalene gel (EPIDUO™ Gel)
7 Clinical Evaluation of T.R.U.E. TEST in Children and Adolescents Completed NCT00795951 Phase 4
8 Anti-IL-17 a New Treatment for Contact Dermatititis Unknown status NCT02778711 Phase 3 secukinumab
9 Topical Timolol for Superficial Infantile Hemangioma Unknown status NCT01685398 Phase 3 0.5% timolol maleate eye drop;Normal saline
10 A Trial Comparing the Efficacy and Safety of Open Dressing With Petrolatum Jelly vs. Standard Gauze Dressing With Silver Sulfadiazine Completed NCT02109718 Phase 3 Open Dressings with Petrolatum Jelly;Silver Sulfadiazine Gauze Dressing Group
11 Efficacy and Safety Comparing 5% Monoxidil Milky Lotion Versus 5% Minoxidil Solution in Androgenetic Alopecia Unknown status NCT01650272 Phase 1, Phase 2 5% MInoxidil milky lotion;5% Minoxidil solution
12 Clinical Evaluation of the 3 Allergens: Methyldibromoglutharonitrile, Parthenolide and Goldnatriumthiosulphate Completed NCT00133341 Phase 2 Goldnatriomthiosulphate, MDBGN, parthenolide
13 Clinical Evaluation of Bacitracin Completed NCT00132600 Phase 2 bacitracin (allergen)
14 Study of the Intradermal Injection of rHuPH20 or Placebo in Subjects With Nickel Allergic Contact Dermatitis Completed NCT00928447 Phase 2 rHuPH20;Placebo
15 Safety, Tolerability, and Efficacy of 21 Days Dermal Application of MRX-6 on Mild to Moderate Contact Dermatitis Completed NCT00867607 Phase 1, Phase 2 MRX-6;Steroid
16 Study of Apremilast in Atopic or Contact Dermatitis Completed NCT00931242 Phase 2 Apremilast
17 Evaluation of EB01 Cream for the Treatment of Chronic Allergic Contact Dermatitis Not yet recruiting NCT03680131 Phase 2 EB01 Cream Placebo;EB01 Cream 0.2%;EB01 Cream 1.0%;EB01 Cream 2.0%
18 NI-0801 in Allergic Contact Dermatitis Completed NCT01244607 Phase 1 Placebo;NI-0801
19 Immune Response and General Immune Health in Subjects Infected With Herpes Simplex Virus Type 1 (HSV-1) Completed NCT03661541 Phase 1 Squaric Acid Dibutyl Ester
20 CP-481,715 Nickel Allergy Study. Completed NCT00141180 Phase 1 CP-481,715
21 A Study of the Safety, Engraftment, and Action of NB01 in Adults With Moderate Acne Completed NCT03450369 Phase 1
22 Effect of RANKL Inhibition on UV-induced Immunosuppression Completed NCT01978483 Phase 1 Denosumab;Diphenylcyclopropenone;Normal Saline
23 Clinical Evaluation of the Photoallergy Potential of Xenaderm Ointment Completed NCT00645164 Phase 1 Xenaderm
24 NatrOVA Photoallergy Study - NatrOVA Creme Rinse in Healthy Volunteers Completed NCT00605956 Phase 1 NatrOVA Creme Rinse - 1%;NatrOVA Creme Rinse Vehicle Only;Blank Patch
25 Clinical Evaluation of the Photoallergy Potential of Atralin Gel Completed NCT00603772 Phase 1 Atralin (tretinoin) gel, 0.05%
26 Evaluation of Potential Development of Photoallergic Skin Reaction After Use of MC2-01 Cream Recruiting NCT03899064 Phase 1 Application of MC2-01 Cream, irradiation;Application of MC2-01 Cream;Applications of MC2-01 vehicle, irradiation;Applications ofh MC2-01 vehicle;Control, irradiation;Control
27 Pathophysiological Study of Allergic Contact Dermatitis to Para-Phenylenediamine (PPD). Analysis of Cellular and Molecular Targets in Skin Inflammation Unknown status NCT00445029
28 Nickel Desensitization Using Topical Therapy Unknown status NCT01413477 Not Applicable Calcipotriol, Betamethasone, Calcipotriol & Betamethasone
29 A Randomised Clinical Trial in a Population of Health Care Workers With Hand Eczema Unknown status NCT01012453 Not Applicable
30 Evaluating Results of Regularly Applied Emollient - Spray in Atopic Dermatitis Therapy Unknown status NCT02763722 Not Applicable
31 Contact Allergies to Dental Metal as a Possible Risk Factor for Oral Cancer Completed NCT00693550
32 Intervention Study to Evaluate the Importance of Information Given to Patients With Contact Allergy Completed NCT01953380 Not Applicable
33 Immune Reactions in Contact Dermatitis Affected Skin Completed NCT01546298
34 Low Dose Exposure to Oxidized R-limonene - A Repeated Open Application Test (ROAT) Study Completed NCT03313232 Not Applicable
35 Evaluating for Contact Allergies in Patients With Chronic Urticaria Completed NCT00868036 Not Applicable
36 Epidemiology and Co-Reactivity of Novel Surfactant Allergens Completed NCT02534441 Not Applicable
37 Short Repeated Nickel Exposures Completed NCT03309215 Not Applicable
38 Evaluation of Tetrix Cream in the Healing of Injured Skin in Subjects With Contact Dermatitis Completed NCT00643214 Not Applicable
39 Human Repeated Insult Patch Test Completed NCT03474874 Not Applicable
40 Cumulative Irritation Patch Test Completed NCT01842711
41 Nickel Allergy and Systemic Nickel Allergy Syndrome in Non Celiac Wheat Sensitivity Completed NCT02750735
42 Safety of a Powder-free Latex Allergy Protocol in the Operating Theatre: A Prospective, Observational Cohort Study Completed NCT02575053
43 Quality of Life Assessment Before and After Essure Removal Completed NCT03401437
44 Red Grape Polyphenol Oral Administration to Women Affected by Nickel-mediated Allergic Contact Dermatitis Completed NCT03902392 Not Applicable
45 NeoMatriX Wound Matrix Collagen Dressing Skin Prick Test Completed NCT03522675 Not Applicable
46 To Assess the Photosensitisation and Photoallergy Potential of a Cosmetic Facial Product in Healthy Participants Completed NCT03183518 Not Applicable
47 Human Photoallergy Test (824/2016) Completed NCT02962869 Not Applicable BAY987517
48 To Test for Photo Allergy Reaction of Sunscreens Completed NCT02872220 Not Applicable SPF 50 Y65 110 (BAY987519);SPF 50 Y51 002 (BAY987519);SPF 15 V27 104 (BAY987519);Sodium chloride [NaCl]
49 18349-Human Photoallergy Test Completed NCT02823496 Not Applicable
50 Human Photoallergy Test Completed NCT02751515 Not Applicable

Search NIH Clinical Center for Allergic Contact Dermatitis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: dermatitis, allergic contact

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Genetic Tests for Allergic Contact Dermatitis

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Anatomical Context for Allergic Contact Dermatitis

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MalaCards organs/tissues related to Allergic Contact Dermatitis:

42
Testes, Skin, T Cells, Eye, Bone, Lymph Node, Endothelial
Sources

Publications for Allergic Contact Dermatitis

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Articles related to Allergic Contact Dermatitis:

(show top 50) (show all 2999)
# Title Authors Year
1
Allergic contact dermatitis caused by oxidized linalool in a deodorant. ( 30912148 )
2019
2
Occupational allergic contact dermatitis caused by colophonium. ( 30229960 )
2019
3
Allergic contact dermatitis caused by isopropyl lauroyl sarcosinate. ( 30238468 )
2019
4
Occupational allergic contact dermatitis caused by cobalt in machine oil. ( 30246382 )
2019
5
"Crossed" allergic contact dermatitis caused by oxidized vitamin K1 in a patient previously sensitized to non-oxidized vitamin K1. ( 30264888 )
2019
6
Allergic contact dermatitis caused by vinylpyrrolidone/eicosene copolymer in a sunscreen. ( 30304757 )
2019
7
Allergic contact dermatitis caused by Dermabond in a paediatric patient undergoing skin surgery. ( 30304758 )
2019
8
Allergic contact dermatitis caused by clindamycin. ( 30311633 )
2019
9
Allergic contact dermatitis to slime: The epidemic of isothiazolinone allergy encompasses school glue. ( 30318714 )
2019
10
Occupational airborne allergic contact dermatitis caused by N-(4-hydroxyphenyl)benzenesulfonamide. ( 30334269 )
2019
11
Two cases of occupational allergic contact dermatitis caused by abacavir. ( 30467867 )
2019
12
Tertiary prevention of occupational skin diseases: Prevalence of allergic contact dermatitis and pattern of patch test results. ( 30506828 )
2019
13
Allergic contact dermatitis caused by cysteamine hydrochloride in permanent wave agent-A new allergen for hairdressers in Japan. ( 30536392 )
2019
14
The effect of anti-IL-17 treatment on the reaction to a nickel patch test in patients with allergic contact dermatitis. ( 30549005 )
2019
15
Allergic Contact Dermatitis to Henna Tattoo with Negative Patch to p-phenylenediamine (PPD). ( 30598181 )
2019
16
Severe allergic contact dermatitis caused by topical bufexamac requiring hospitalization. ( 30624772 )
2019
17
Allergic contact dermatitis from topical ophthalmic medications: keep an eye on it! ( 30629291 )
2019
18
A retrospective review of dupilumab for atopic dermatitis patients with allergic contact dermatitis. ( 30630024 )
2019
19
Cinnamon-Induced airborne occupational allergic contact dermatitis in a baker: severe flare-up during patch testing. ( 30653675 )
2019
20
Methylisothiazolinone allergic contact dermatitis: assessment of relapses in 139 patients after avoidance advice. ( 30653676 )
2019
21
Allergic contact dermatitis caused by isopropyl methylphenol, a new hapten. ( 30653678 )
2019
22
ALLERGIC CONTACT DERMATITIS PROBABLY DUE TO LATANOPROST DURING TREATMENT FOR ALOPECIA AREATA. ( 30663070 )
2019
23
Occupational lichenoid allergic contact dermatitis caused by tin. ( 30714170 )
2019
24
Serum galectin-9 levels in atopic dermatitis, psoriasis and allergic contact dermatitis: A cross-sectional study. ( 30719989 )
2019
25
Allergic contact dermatitis to gold weight upper-eyelid implant. ( 30720892 )
2019
26
Pigments in American Tattoo Inks and their Propensity to Elicit Allergic Contact Dermatitis. ( 30731175 )
2019
27
Allergic contact dermatitis to (meth)acrylates involving nail technicians and users: prognosis and differential diagnosis. ( 30739348 )
2019
28
Allergic contact dermatitis caused by isobornyl acrylate when using the FreeStyle® Libre. ( 30758915 )
2019
29
Contact Allergy and Allergic Contact Dermatitis to Lavender: A Retrospective Study from an Australian Clinic. ( 30779160 )
2019
30
Occupational allergic contact dermatitis to sulfite in a seafood section worker of a supermarket. ( 30779161 )
2019
31
Artificial nail wearing: unexpected elicitor of allergic contact dermatitis, oral lichen planus and risky arthroplasty. ( 30793321 )
2019
32
Effect of Patch Testing on the Course of Allergic Contact Dermatitis and Prognostic Factors That Influence Outcomes. ( 30829803 )
2019
33
Allergic Contact Dermatitis to a Self-Adherent Bandage Wrap in a Formaldehyde-Allergic Patient. ( 30829806 )
2019
34
Allergic Contact Dermatitis to Shin Pads in a Hockey Player: Acetophenone Is an Emerging Allergen. ( 30829808 )
2019
35
Airborne Allergic Contact Dermatitis: Management and Responsible Allergens on the American Contact Dermatitis Society Core Series. ( 30829811 )
2019
36
Allergic contact dermatitis and electronic cigarettes: is nickel to blame? ( 30834540 )
2019
37
Allergic contact dermatitis to neem oil: an underrated allergen? ( 30834541 )
2019
38
Allergic contact dermatitis to chlorhexidine in pediatric patients. ( 30838689 )
2019
39
Allergic contact dermatitis caused by a Brazilian exotic hardwood. ( 30843225 )
2019
40
Blocking type 2 inflammation by dupilumab does not control classic (Type 1-driven) allergic contact dermatitis in chronic hand eczema. ( 30851059 )
2019
41
Lichen sclerosus et atrophicus and allergic contact dermatitis: A significant association. ( 30864217 )
2019
42
Variable impact of dupilumab on patch testing results and allergic contact dermatitis in adults with atopic dermatitis. ( 30885752 )
2019
43
Allergic contact dermatitis to phenylbenzimidazole sulfonic acid included in a sunscreen. ( 30891767 )
2019
44
Allergic contact dermatitis to synthetic rubber gloves in healthcare workers: sensitization to 1,3-diphenylguanidine is common. ( 30891769 )
2019
45
Allergic contact dermatitis caused by benzisothiazolinone in a continuous positive airway pressure mask liquid soap. ( 30903668 )
2019
46
Amorphous silicon dioxide nanoparticles modulate immune responses in a model of allergic contact dermatitis. ( 30911099 )
2019
47
Allergic Contact Dermatitis Due to Chlorhexidine in 2 Pediatric Patients. ( 29576187 )
2019
48
Allergic Contact Dermatitis Due to Methyl Glucose Dioleate in a Balm Cream. ( 29598994 )
2019
49
Allergic contact dermatitis caused by octylisothiazolinone in a leather sofa. ( 29790173 )
2018
50
Chemokine Signaling in Allergic Contact Dermatitis: Toward Targeted Therapies. ( 29939854 )
2018
Sources

Variations for Allergic Contact Dermatitis

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Expression for Allergic Contact Dermatitis

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Search GEO for disease gene expression data for Allergic Contact Dermatitis.
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Pathways for Allergic Contact Dermatitis

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Pathways related to Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 67
Show member pathways
 14.05 CXCL8 ICAM1 IFNG IL10 IL17A IL1B
2
ERK Signaling 65
Show member pathways
 13.86 CCL17 CXCL8 CXCR3 IL10 IL17A IL1B
3
PEDF Induced Signaling 65
Show member pathways
 13.72 CCL17 CXCL8 CXCR3 IFNG IL10 IL17A
4
TGF-Beta Pathway 65
Show member pathways
 13.59 CCL17 CXCL8 ICAM1 IFNG IL10 IL17A
5
Akt Signaling 65
Show member pathways
 13.47 CCL17 CXCL8 CXCR3 IL10 IL17A IL1B
6
Cytokine Signaling in Immune system 67
Show member pathways
 13.42 CXCL8 ICAM1 IFNG IL10 IL17A IL1B
7
PAK Pathway 65
Show member pathways
 13.36 CCL17 CXCL8 CXCR3 IL10 IL17A IL1B
8
Toll-like Receptor Signaling Pathway 38 1
Show member pathways
 13.18 CXCL8 IFNG IL10 IL1B TNF
9
Allograft rejection 1 38
Show member pathways
 12.97 CXCL8 ICAM1 IFNG IL10 IL17A IL1B
10
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 67
Show member pathways
 12.8 CXCL8 IFNG IL1B IL33 TNF
11
Th17 cell differentiation 38
Show member pathways
 12.7 IFNG IL10 IL17A IL1B IL4 IL5
12
Influenza A 38
Show member pathways
 12.68 CXCL8 ICAM1 IFNG IL1B IL33 IL4
13
NF-kappaB Signaling 4
12.66 IFNG IL10 IL17A IL1B IL4 TNF
14
Immune response IL-23 signaling pathway 23
Show member pathways
 12.64 IFNG IL10 IL17A IL1B TNF
15
T cell receptor signaling pathway 38
Show member pathways
 12.54 IFNG IL10 IL17A IL1B IL4 IL5
16
Immune response Role of DAP12 receptors in NK cells 23
Show member pathways
 12.52 ICAM1 IFNG IL4 TNF
17
Selenium Micronutrient Network 1
Show member pathways
 12.42 ICAM1 IFNG IL1B IL4 TNF
18
JAK-STAT signaling pathway (KEGG) 66
Show member pathways
 12.41 IFNG IL10 IL4 IL5
19
IL-17 Family Signaling Pathways 66
Show member pathways
 12.41 CCL17 CXCL8 IFNG IL17A IL1B IL4
20
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.36 CXCL8 IFNG IL10 IL17A IL1B IL4
21
Toxoplasmosis 38
Show member pathways
 12.35 IFNG IL10 IL1B IL4 TNF
22
Toll Comparative Pathway 65
Show member pathways
 12.33 CXCL8 IFNG IL1B TNF
23
Bacterial infections in CF airways 23
Show member pathways
 12.29 CXCL8 IFNG IL1B IL4 TNF
24
Tuberculosis 38
12.28 IFNG IL10 IL1B TNF
25
IL-1 Family Signaling Pathways 66
Show member pathways
 12.28 CXCL8 IL1B IL33 TNF
26
C-type lectin receptor signaling pathway 38
Show member pathways
 12.26 CCL17 IL10 IL1B TNF
27
Necroptosis 38
Show member pathways
 12.26 IFNG IL1B IL33 TNF
28
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 23
Show member pathways
 12.24 CCL17 CXCL8 CXCR3 ICAM1 IL1B
29
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.23 CXCL8 IL10 IL1B TNF
30
Fluid shear stress and atherosclerosis 38
12.2 ICAM1 IFNG IL1B SELE TNF
31
Th1 Differentiation Pathway 66
Show member pathways
 12.17 IFNG IL10 IL17A IL1B TNF
32
Spinal Cord Injury 1
12.14 CXCL8 ICAM1 IFNG IL1B IL4 TNF
33
Immune response IFN gamma signaling pathway 23
Show member pathways
 12.12 CCL17 CXCL8 ICAM1 IFNG IL10 IL17A
34
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 66
12.11 IFNG IL10 IL4 IL5 TNF
35
Microglia Activation During Neuroinflammation: Overview 66
Show member pathways
 12.1 IFNG IL1B IL4 TNF
36
Interleukin-4 and 13 signaling 67
12.1 CXCL8 ICAM1 IL10 IL17A IL1B IL4
37
TNF signaling pathway 38
12.04 ICAM1 IL1B SELE TNF
38
AGE-RAGE signaling pathway in diabetic complications 38
12.04 CXCL8 ICAM1 IL1B SELE TNF
39
Amoebiasis 38
12.01 CXCL8 IFNG IL10 IL1B TNF
40
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 66
Show member pathways
 11.99 CCL17 CXCL8 CXCR3
41
Rheumatoid arthritis 38
11.99 CXCL8 ICAM1 IFNG IL17A IL1B TNF
42
IL12-mediated signaling events 1
Show member pathways
 11.98 IFNG IL1B IL4
43
Hematopoietic cell lineage 38
11.98 IL1B IL4 IL5 TNF
44
NF-kappa B signaling pathway 38
11.97 CXCL8 ICAM1 IL1B TNF
45
Senescence and Autophagy in Cancer 1
11.95 CXCL8 IFNG IL1B
46
Glucocorticoid receptor regulatory network 1
11.93 CXCL8 ICAM1 IFNG IL4 IL5 SELE
47
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.9 CXCL8 IFNG IL4 IL5 TNF
48
Cytokine production by Th17 cells in CF (Mouse model) 23
Show member pathways
 11.89 CXCL8 ICAM1 IL17A
49
Pertussis 38
11.87 CXCL8 IL10 IL1B TNF
50
Salmonella infection (KEGG) 38
11.85 CXCL8 IFNG IL1B
Sources

GO Terms for Allergic Contact Dermatitis

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Cellular components related to Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 CCL17 CXCL8 IFNG IL10 IL17A IL1B
2 external side of plasma membrane GO:0009897 9.46 CXCR3 ICAM1 IL17A TNF
3 extracellular space GO:0005615 9.44 CCL17 CXCL8 ICAM1 IFNG IL10 IL17A

Biological processes related to Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Name GO ID Score Top Affiliating Genes
1 leukocyte migration GO:0050900 9.93 ICAM1 IL1B SELE TNF
2 response to lipopolysaccharide GO:0032496 9.91 ICAM1 IL10 IL1B SELE
3 inflammatory response GO:0006954 9.91 CCL17 CXCL8 CXCR3 IL10 IL17A IL1B
4 calcium-mediated signaling GO:0019722 9.86 CXCL8 CXCR3 SELE
5 neutrophil chemotaxis GO:0030593 9.85 CCL17 CXCL8 IL1B
6 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.85 CCL17 ICAM1 TNF
7 chemokine-mediated signaling pathway GO:0070098 9.85 CCL17 CXCL8 CXCR3
8 immune response GO:0006955 9.85 CCL17 CXCL8 CXCR3 IFNG IL10 IL17A
9 regulation of insulin secretion GO:0050796 9.83 IFNG IL1B TNF
10 positive regulation of DNA-binding transcription factor activity GO:0051091 9.83 IL10 IL1B IL5 TNF
11 cellular response to lipopolysaccharide GO:0071222 9.83 CXCL8 ICAM1 IL10 IL1B TNF
12 positive regulation of interleukin-6 production GO:0032755 9.82 IL1B IL33 TNF
13 cellular response to interleukin-1 GO:0071347 9.8 CCL17 CXCL8 ICAM1 IL17A
14 extrinsic apoptotic signaling pathway GO:0097191 9.77 IFNG IL33 TNF
15 negative regulation of endothelial cell apoptotic process GO:2000352 9.72 ICAM1 IL10 IL4
16 negative regulation of lipid catabolic process GO:0050995 9.71 IL1B TNF
17 positive regulation of glial cell proliferation GO:0060252 9.71 IL1B TNF
18 positive regulation of macrophage activation GO:0043032 9.71 IL10 IL33
19 positive regulation of nitric oxide biosynthetic process GO:0045429 9.71 ICAM1 IFNG IL1B TNF
20 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.7 IL1B TNF
21 negative regulation of growth of symbiont in host GO:0044130 9.7 IL10 TNF
22 positive regulation of immunoglobulin secretion GO:0051024 9.69 IL33 IL5
23 positive regulation of podosome assembly GO:0071803 9.69 IL5 TNF
24 response to molecule of bacterial origin GO:0002237 9.69 CXCL8 IL10
25 positive regulation of osteoclast differentiation GO:0045672 9.69 IFNG IL17A TNF
26 positive regulation of chemokine secretion GO:0090197 9.68 IL33 TNF
27 positive regulation of interleukin-13 production GO:0032736 9.68 IL33 IL4
28 endothelial cell apoptotic process GO:0072577 9.67 IL10 TNF
29 positive regulation of chemokine biosynthetic process GO:0045080 9.66 IL1B TNF
30 response to glucocorticoid GO:0051384 9.65 IL10 TNF
31 positive regulation of MHC class II biosynthetic process GO:0045348 9.65 IL10 IL4
32 regulation of establishment of endothelial barrier GO:1903140 9.65 IL1B TNF
33 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.65 IFNG IL1B TNF
34 negative regulation of cytokine secretion involved in immune response GO:0002740 9.64 IL10 TNF
35 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.63 ICAM1 TNF
36 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.63 IL10 IL1B TNF
37 positive regulation of fever generation GO:0031622 9.62 IL1B TNF
38 positive regulation of interleukin-23 production GO:0032747 9.61 IFNG IL17A
39 cytokine-mediated signaling pathway GO:0019221 9.61 CXCL8 ICAM1 IL10 IL17A IL1B IL31
40 regulation of isotype switching GO:0045191 9.58 IL10 IL4
41 sequestering of triglyceride GO:0030730 9.58 IL1B TNF
42 type 2 immune response GO:0042092 9.57 IL10 IL4
43 receptor biosynthetic process GO:0032800 9.56 IL10 TNF
44 positive regulation of vitamin D biosynthetic process GO:0060557 9.54 IFNG TNF
45 positive regulation of neuroinflammatory response GO:0150078 9.54 IL1B IL33 TNF
46 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.5 IFNG IL1B TNF
47 regulation of signaling receptor activity GO:0010469 9.36 CCL17 CXCL8 IFNG IL10 IL17A IL1B
48 chronic inflammatory response to antigenic stimulus GO:0002439 9.29 TNF
49 positive regulation of transcription by RNA polymerase II GO:0045944 10.18 IL10 IL17A IL1B IL33 IL4 TNF
50 positive regulation of transcription, DNA-templated GO:0045893 10.09 IL10 IL1B IL4 IL5 TNF

Molecular functions related to Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.8 CCL17 CXCL8 FLG ICAM1 IFNG IL10
2 cytokine activity GO:0005125 9.36 CCL17 CXCL8 IFNG IL10 IL17A IL1B
Sources

Sources for Allergic Contact Dermatitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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