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MCID: ALL010
MIFTS: 59

Allergic Contact Dermatitis

Categories: Skin diseases, Immune diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Allergic Contact Dermatitis

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MalaCards integrated aliases for Allergic Contact Dermatitis:

Name: Allergic Contact Dermatitis 12 37 15 63
Dermatitis, Allergic Contact 44 73
Contact Dermatitis, Allergic 76
Dermatitis Allergic Contact 55

Classifications:

MalaCards categories:
Anatomical: Skin diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:3042
MeSH 44 D017449
NCIt 50 C26998
SNOMED-CT 68 200841005 238575004
KEGG 37 H01357
UMLS 73 C0162820
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Summaries for Allergic Contact Dermatitis

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PubMed Health : 63 About allergic contact dermatitis: A number of chemical or herbal substances can irritate the skin. Redness, burning or itching are normal skin reactions, for instance, to aggressive cleaning agents.Allergic contact dermatitis (sometimes simply called “contact allergies”) is different, though. Here the immune system overreacts to certain substances – sometimes to very small amounts – that normally wouldn’t cause a reaction. Common examples include certain metals, scents and latex rubber.Contact allergies can lead to severe skin reactions. Unlike with many other kinds of allergies, the reaction doesn’t occur immediately, but after one to three days. And contact allergies develop gradually over a long period of time, as a result of repeated contact with the substance that triggers them. Some people are then no longer able to carry on doing the same kind of work as before.

MalaCards based summary : Allergic Contact Dermatitis, also known as dermatitis, allergic contact, is related to alopecia areata and erythema multiforme. An important gene associated with Allergic Contact Dermatitis is IL31 (Interleukin 31), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Bacitracin and Bronopol have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and t cells, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Disease Ontology : 12 A contact dermititis that is an allergic skin reaction to foreign chemical or substances leading to red, itchy, weepy reaction where the skin has come into contact with a substance that the immune system recognizes as foreign.

Wikipedia : 76 Allergic contact dermatitis (ACD) is a form of contact dermatitis that is the manifestation of an... more...

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Related Diseases for Allergic Contact Dermatitis

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Diseases related to Allergic Contact Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 364)
# Related Disease Score Top Affiliating Genes
1 alopecia areata 30.6 ICAM1 IFNG TNF
2 erythema multiforme 30.5 CCL17 CXCR3 ICAM1 IFNG TNF
3 choroiditis 30.4 IL10 TNF
4 irritant dermatitis 30.1 FLG IL1B TNF
5 burns 30.0 IL1B TNF
6 dermatitis 30.0 CCL17 FLG IFNG IL17A IL31 IL4
7 acute generalized exanthematous pustulosis 29.9 CXCL8 IL17A
8 cutaneous t cell lymphoma 29.9 CCL17 IFNG IL4
9 scabies 29.9 CXCL8 IL10
10 discoid lupus erythematosus 29.8 FLG IL10 NAT2
11 actinic prurigo 29.8 ICAM1 IL1B SELE TNF
12 ige responsiveness, atopic 28.8 FLG IFNG IL10 IL4 IL5
13 lichen planus 28.6 CXCR3 FLG ICAM1 IFNG IL4 TNF
14 contact dermatitis 25.0 CCL17 CXCL8 CXCR3 FLG ICAM1 IFNG
15 dermatitis, atopic 24.9 CCL17 CXCL8 CXCR3 FLG ICAM1 IFNG
16 skin disease 24.6 CCL17 CXCL8 FLG ICAM1 IFNG IL10
17 psoriasis 24.4 CCL17 CXCL8 CXCR3 FLG ICAM1 IFNG
18 asthma 23.3 CCL17 CXCL8 FLG ICAM1 IFNG IL10
19 allergic contact dermatitis of eyelid 12.3
20 occupational dermatitis 11.6
21 photoallergic dermatitis 11.1
22 phototoxic dermatitis 11.1
23 angioimmunoblastic lymphadenopathy with dysproteinemia 10.9 IL5 TNF
24 punctate inner choroidopathy 10.9 IL10 TNF
25 heterophyiasis 10.8 ICAM1 SELE
26 eosinophilic fasciitis 10.8 IFNG IL5
27 lymphocytic vasculitis 10.8 ICAM1 SELE
28 critical limb ischemia 10.8 SELE TNF
29 microscopic polyangiitis 10.8 IL10 TNF
30 multifocal choroiditis 10.8 IL10 TNF
31 transient hypogammaglobulinemia 10.7 IL10 TNF
32 rheumatoid vasculitis 10.7 ICAM1 SELE TNF
33 chronic eosinophilic pneumonia 10.7 CXCR3 ICAM1 IL5
34 mooren's ulcer 10.7 ICAM1 SELE
35 chronic beryllium disease 10.7 IFNG TNF
36 african tick-bite fever 10.6 IFNG SELE
37 rheumatoid lung disease 10.6 IL17A TNF
38 paragonimiasis 10.6 CCL17 CXCR3 IL5
39 primary progressive multiple sclerosis 10.6 ICAM1 IL10 TNF
40 epidermolysis bullosa pruriginosa 10.6 FLG IL31
41 sporotrichosis 10.6 IFNG IL10
42 mycoplasmal pneumonia 10.5 IFNG IL4
43 vasculitis 10.5 ICAM1 SELE TNF
44 atherosclerosis susceptibility 10.5 ICAM1 SELE TNF
45 hemorrhagic fever 10.5 IFNG IL10 TNF
46 spotted fever 10.5 IFNG IL10 TNF
47 hematopoietic stem cell transplantation 10.5 IFNG IL10 TNF
48 autoimmune enteropathy 10.5 ICAM1 IL17A
49 multicentric castleman disease 10.5 IFNG IL10 IL5
50 idiopathic achalasia 10.5 IL10 IL33 TNF

Graphical network of the top 20 diseases related to Allergic Contact Dermatitis:



Diseases related to Allergic Contact Dermatitis
Sources

Symptoms & Phenotypes for Allergic Contact Dermatitis

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GenomeRNAi Phenotypes related to Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.4 CXCL8 ICAM1 IL10 IL17A IL1B TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.4 CXCL8 ICAM1 IL10 IL17A IL1B TNF

MGI Mouse Phenotypes related to Allergic Contact Dermatitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.15 IL33 IFNG IL4 IL10 IL5 CCL17
2 homeostasis/metabolism MP:0005376 10.1 IL1B ICAM1 IL33 IFNG IL4 IL10
3 immune system MP:0005387 10.03 IL33 IFNG IL4 IL10 CCL17 IL17A
4 digestive/alimentary MP:0005381 10.01 IL33 IFNG IL4 IL10 IL17A ICAM1
5 craniofacial MP:0005382 9.91 IL1B IFNG IL4 IL10 IL17A TNF
6 integument MP:0010771 9.76 IL1B ICAM1 IL33 IFNG IL4 IL10
7 neoplasm MP:0002006 9.5 ICAM1 IFNG IL10 CXCR3 IL1B IL5
8 respiratory system MP:0005388 9.28 IL33 IFNG IL4 IL10 IL5 IL17A
Sources

Drugs & Therapeutics for Allergic Contact Dermatitis

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PubMedHealth treatment related to Allergic Contact Dermatitis: 63

Allergic skin reactions are usually treated with steroid creams, ointments or solutions.But the main thing to do is avoid contact with the substance that triggers the reaction. Protective gloves and clothing can help here, for instance.A change of career may have to be considered if it isn’t possible to avoid contact with the substance in the workplace. If you are believed to have a work-related contact allergy, it’s a good idea to have your doctor inform your employer’s liability insurance. The insurance will cover certain costs, like the costs of protective measures, if the allergy is recognized as being work-related.

Drugs for Allergic Contact Dermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 89)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bacitracin Approved, Vet_approved Phase 4,Phase 2 1405-87-4 439542 10909430
2
Bronopol Approved Phase 4 52-51-7
3
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
4 Parthenolide Approved, Investigational Phase 4,Phase 2 20554-84-1
5
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
6
Povidone Approved Phase 4 9003-39-8
7
Adapalene Approved Phase 4 106685-40-9 60164
8
Benzoyl peroxide Approved Phase 4 94-36-0 7187
9
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
10
Butyric Acid Experimental, Investigational Phase 4 107-92-6 264
11 Analgesics Phase 4,Phase 2
12 Analgesics, Non-Narcotic Phase 4,Phase 2
13 Anti-Bacterial Agents Phase 4,Phase 2,Not Applicable
14 Antidotes Phase 4
15 Anti-Infective Agents Phase 4,Phase 3,Phase 2
16 Anti-Infective Agents, Local Phase 4,Phase 3,Phase 2
17 Anti-Inflammatory Agents Phase 4,Phase 2,Not Applicable
18 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2
19 Antioxidants Phase 4
20 Antirheumatic Agents Phase 4,Phase 2
21 Antitubercular Agents Phase 4
22 Chelating Agents Phase 4
23 Cortisol succinate Phase 4
24 Dermatologic Agents Phase 4,Phase 3,Not Applicable
25 Gold Sodium Thiosulfate Phase 4
26 Hydrocortisone 17-butyrate 21-propionate Phase 4
27 Hydrocortisone acetate Phase 4
28 Hydrocortisone-17-butyrate Phase 4
29 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
30 Protective Agents Phase 4
31 sodium thiosulfate Phase 4
32 Calcineurin Inhibitors Phase 4
33 Immunosuppressive Agents Phase 4,Phase 2
34 Adapalene, Benzoyl Peroxide Drug Combination Phase 4
35 Clindamycin palmitate Phase 4
36 Clindamycin phosphate Phase 4
37
Ephedrine Approved Phase 3 299-42-3 9294
38
Pseudoephedrine Approved Phase 3 90-82-4 7028
39
Timolol Approved Phase 3 26839-75-8 33624 5478
40
Petrolatum Approved, Investigational Phase 3,Not Applicable 8009-03-8
41
Silver sulfadiazine Approved, Vet_approved Phase 3 22199-08-2 441244
42
Sulfadiazine Approved, Investigational, Vet_approved Phase 3 68-35-9 5215
43
Maleic acid Experimental Phase 3 110-16-7 444266
44 Antibodies Phase 3
45 Antibodies, Monoclonal Phase 3
46 Immunoglobulins Phase 3
47 Adrenergic Agents Phase 3
48 Adrenergic Antagonists Phase 3
49 Adrenergic beta-Antagonists Phase 3
50 Anti-Arrhythmia Agents Phase 3

Interventional clinical trials:

(show all 37)
# Name Status NCT ID Phase Drugs
1 Clinical Evaluation of T.R.U.E. Test Allergens in Children an Adolescents Unknown status NCT01797562 Phase 4 T.R.U.E. Test Panel 3.2
2 Quaternium-15, Use Test Unknown status NCT00311454 Phase 4 T.R.U.E.Test
3 Study of the Safety and Efficacy of Tacrolimus Ointment in Treating Chronic Allergic Contact Dermatitis Completed NCT00667056 Phase 4 tacrolimus ointment;placebo ointment
4 Bioequivalence of Ethylenediamine Dihydrochloride Study Completed NCT01798589 Phase 4 Ethylenediamine dihydrochloride
5 A Comparative Study of the Tolerability of Two Combination Therapies for the Treatment of Acne Completed NCT00887484 Phase 4 BENZOYL PEROXIDE/ CLINDAMYCIN;BENZOYL PEROXIDE/ ADAPALENE
6 A Study to Evaluate Tolerability of Two Topical Drug Products in the Treatment of Facial Acne Completed NCT00964223 Phase 4 Clindamycin and benzoyl peroxide gel (Duac® Topical Gel);benzoyl peroxide and adapalene gel (EPIDUO™ Gel)
7 Clinical Evaluation of T.R.U.E. TEST in Children and Adolescents Completed NCT00795951 Phase 4
8 Anti-IL-17 a New Treatment for Contact Dermatititis Unknown status NCT02778711 Phase 3 secukinumab
9 Topical Timolol for Superficial Infantile Hemangioma Unknown status NCT01685398 Phase 3 0.5% timolol maleate eye drop;Normal saline
10 A Trial Comparing the Efficacy and Safety of Open Dressing With Petrolatum Jelly vs. Standard Gauze Dressing With Silver Sulfadiazine Completed NCT02109718 Phase 3 Open Dressings with Petrolatum Jelly;Silver Sulfadiazine Gauze Dressing Group
11 Efficacy and Safety Comparing 5% Monoxidil Milky Lotion Versus 5% Minoxidil Solution in Androgenetic Alopecia Unknown status NCT01650272 Phase 1, Phase 2 5% MInoxidil milky lotion;5% Minoxidil solution
12 Clinical Evaluation of the 3 Allergens: Methyldibromoglutharonitrile, Parthenolide and Goldnatriumthiosulphate Completed NCT00133341 Phase 2 Goldnatriomthiosulphate, MDBGN, parthenolide
13 Clinical Evaluation of Bacitracin Completed NCT00132600 Phase 2 bacitracin (allergen)
14 Study of the Intradermal Injection of rHuPH20 or Placebo in Subjects With Nickel Allergic Contact Dermatitis Completed NCT00928447 Phase 2 rHuPH20
15 Safety, Tolerability, and Efficacy of 21 Days Dermal Application of MRX-6 on Mild to Moderate Contact Dermatitis Completed NCT00867607 Phase 1, Phase 2 MRX-6;Steroid
16 Study of Apremilast in Atopic or Contact Dermatitis Completed NCT00931242 Phase 2 Apremilast
17 NI-0801 in Allergic Contact Dermatitis Completed NCT01244607 Phase 1 Placebo;NI-0801
18 CP-481,715 Nickel Allergy Study. Completed NCT00141180 Phase 1 CP-481,715
19 A Study of the Safety, Engraftment, and Action of NB01 in Adults With Moderate Acne Active, not recruiting NCT03450369 Phase 1
20 Pathophysiological Study of Allergic Contact Dermatitis to Para-Phenylenediamine (PPD). Analysis of Cellular and Molecular Targets in Skin Inflammation Unknown status NCT00445029
21 Nickel Desensitization Using Topical Therapy Unknown status NCT01413477 Not Applicable Calcipotriol, Betamethasone, Calcipotriol & Betamethasone
22 A Randomised Clinical Trial in a Population of Health Care Workers With Hand Eczema Unknown status NCT01012453 Not Applicable
23 Evaluating Results of Regularly Applied Emollient - Spray in Atopic Dermatitis Therapy Unknown status NCT02763722 Not Applicable
24 Contact Allergies to Dental Metal as a Possible Risk Factor for Oral Cancer Completed NCT00693550
25 Intervention Study to Evaluate the Importance of Information Given to Patients With Contact Allergy Completed NCT01953380 Not Applicable
26 Immune Reactions in Contact Dermatitis Affected Skin Completed NCT01546298
27 Low Dose Exposure to Oxidized R-limonene - A Repeated Open Application Test (ROAT) Study Completed NCT03313232 Not Applicable
28 Evaluating for Contact Allergies in Patients With Chronic Urticaria Completed NCT00868036 Not Applicable
29 Epidemiology and Co-Reactivity of Novel Surfactant Allergens Completed NCT02534441 Not Applicable
30 Short Repeated Nickel Exposures Completed NCT03309215 Not Applicable
31 Evaluation of Tetrix Cream in the Healing of Injured Skin in Subjects With Contact Dermatitis Completed NCT00643214 Not Applicable
32 Cumulative Irritation Patch Test Completed NCT01842711
33 Nickel Allergy and Systemic Nickel Allergy Syndrome in Non Celiac Wheat Sensitivity Completed NCT02750735
34 Safety of a Powder-free Latex Allergy Protocol in the Operating Theatre: A Prospective, Observational Cohort Study Completed NCT02575053
35 Improving Value of Care for Patients With Severe Stasis Dermatitis Recruiting NCT03022786 Not Applicable
36 Cutaneous and Systemic Reactions to Metal Implants Recruiting NCT02483728 Not Applicable
37 Quality of Life Assessment Before and After Essure Removal Not yet recruiting NCT03401437

Search NIH Clinical Center for Allergic Contact Dermatitis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: dermatitis, allergic contact

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Genetic Tests for Allergic Contact Dermatitis

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Anatomical Context for Allergic Contact Dermatitis

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MalaCards organs/tissues related to Allergic Contact Dermatitis:

41
Skin, Testes, T Cells, Eye, Bone, Monocytes, Tongue
Sources

Publications for Allergic Contact Dermatitis

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Articles related to Allergic Contact Dermatitis:

(show top 50) (show all 757)
# Title Authors Year
1
Allergic contact dermatitis caused by octylisothiazolinone in a leather sofa. ( 29790173 )
2018
2
Chemokine Signaling in Allergic Contact Dermatitis: Toward Targeted Therapies. ( 29939854 )
2018
3
Allergic contact dermatitis caused by acrylic-based medical dressings and adhesives. ( 29888412 )
2018
4
Declining prevalence of allergic contact dermatitis caused by tosylamide formaldehyde resin in nail polish. ( 29726606 )
2018
5
Allergic contact dermatitis resulting from cetyl PEG/PPG-10/1 dimethicone in a deodorant cream. ( 29430705 )
2018
6
Pediatric "pet consort dermatitis"-Allergic contact dermatitis from transfer of bronopol from a pet cat. ( 29943851 )
2018
7
Allergic contact dermatitis caused by hydroxyacetophenone in a face cream. ( 29341188 )
2018
8
Allergic contact dermatitis caused by triethylenetetramine: the glue is the clue. ( 29392782 )
2018
9
Glove-Related Allergic Contact Dermatitis. ( 29901500 )
2018
10
Kumkum-induced allergic contact dermatitis: Are we missing the actual culprit? ( 29393081 )
2018
11
Occupational allergic contact dermatitis caused by antibiotics in healthcare workersA -A relationship with non-immediate drug eruptions. ( 29399806 )
2018
12
Involvement of the Negative Feedback of IL-33 Signaling in the Anti-Inflammatory Effect of Electro-acupuncture on Allergic Contact Dermatitis via Targeting MicroRNA-155 in Mast Cells. ( 29404871 )
2018
13
Chromium(III) release from chromium-tanned leather elicits allergic contact dermatitis: a use test study. ( 29322530 )
2018
14
Silkworm dropping extract ameliorate trimellitic anhydride-induced allergic contact dermatitis by regulating Th1/Th2 immune response. ( 29806566 )
2018
15
Short contact with nickel causes allergic contact dermatitis: an experimental study. ( 29959775 )
2018
16
Severe allergic contact dermatitis mimicking angioedema caused by propolis used as a traditional remedy. ( 29845630 )
2018
17
Allergic contact dermatitis caused by benzyl salicylate in hair products. ( 29943414 )
2018
18
Contact Buzz: Allergic Contact Dermatitis to Cannabis. ( 29933254 )
2018
19
A case of allergic contact dermatitis caused by Disperse Blue dye in ultrasound gel. ( 29766523 )
2018
20
Relapsing polyisoprene glove allergic contact dermatitis: Another call for more complete glove package label declaration. ( 29785753 )
2018
21
First report of allergic contact dermatitis caused by sorbitan caprylate. ( 29341184 )
2018
22
Occupational allergic contact dermatitis caused by nickel in embroidery needles. ( 29781177 )
2018
23
Allergic contact dermatitis from formaldehyde mimicking impetigo and initiating rosacea. ( 29611264 )
2018
24
Innate immunity and effector and regulatory mechanisms involved in allergic contact dermatitis. ( 29723367 )
2018
25
Possible role of regional variation in allergic contact dermatitis: case report. ( 29430710 )
2018
26
Anti-pruritic and anti-inflammatory effects of oxymatrine in a mouse model of allergic contact dermatitis. ( 29903654 )
2018
27
A novel case of a brush with discomfort: allergic contact dermatitis caused by mercaptobenzothiazole in rubber components of a toothbrush. ( 29446120 )
2018
28
Allergic contact dermatitis caused by Solvent Orange 60 in spectacle frames in Japan. ( 29265444 )
2018
29
Non-occupational allergic contact dermatitis caused by long-lasting nail polish kits for home use: 'the tip of the iceberg'. ( 29327355 )
2018
30
Systemic allergic contact dermatitis associated with topical diltiazem and/or cinchocaine. ( 29423962 )
2018
31
Lymphocyte surface markers and cytokines are suitable for detection and potency assessment of skin-sensitizing chemicals in an in vitro model of allergic contact dermatitis: the LCSA-ly. ( 29380012 )
2018
32
Allergic contact dermatitis caused by a polyurethane catheter. ( 29923607 )
2018
33
Allergic contact dermatitis caused by topical ketoconazole: a relevant issue? Review of ketoconazole-positive patch tests. ( 29430708 )
2018
34
Allergic contact dermatitis caused by plastic items containing the ultraviolet absorber drometrizole. ( 29761506 )
2018
35
Allergic contact dermatitis caused by OlanedineAr (olanexidine gluconate), a new antiseptic. ( 29341182 )
2018
36
A private case of allergic contact dermatitis. ( 29341989 )
2018
37
Allergic Contact Dermatitis-Induced Stereospecificity Overview. ( 29933255 )
2018
38
The Role and Diagnosis of Allergic Contact Dermatitis in Patients with Atopic Dermatitis. ( 29305764 )
2018
39
Isobornyl acrylate contained in the insulin patch pump OmniPod as the cause of severe allergic contact dermatitis. ( 29761499 )
2018
40
Allergic contact dermatitis caused by a moisturizer containing iodopropynyl butylcarbamate. ( 28940475 )
2017
41
Polymorphic light eruption and IL-1 family members: any difference with allergic contact dermatitis? ( 28812775 )
2017
42
Occupational allergic contact dermatitis caused by tetracaine in an otorhinolaryngologist. ( 27957755 )
2017
43
Allergic Contact Dermatitis Due to Methylisothiazolinone in a Young Girl's Laundry Detergent. ( 28523864 )
2017
44
Severe allergic contact dermatitis due to Polysporin. ( 28790058 )
2017
45
Suppressive Effects of Mesenchymal Stem Cells in Adipose Tissue on Allergic Contact Dermatitis. ( 28761285 )
2017
46
Probable allergic contact dermatitis from hydroquinone presenting as leukomelanoderma: Report of two cases. ( 28815722 )
2017
47
Allergic contact dermatitis caused by I/-aminocaproic acid in a purified sodium hyaluronate ophthalmic solution. ( 28766795 )
2017
48
Allergic contact dermatitis caused by benzoic acid and lauryl glucoside in a sunscreen. ( 28766797 )
2017
49
Allergic contact dermatitis caused by efinaconazole: positive patch test reactions up to 0.1% pet. ( 27957750 )
2017
50
Diagnosis and management of allergic contact dermatitis in children: common allergens that can be easily missed. ( 28525402 )
2017
Sources

Variations for Allergic Contact Dermatitis

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Expression for Allergic Contact Dermatitis

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Search GEO for disease gene expression data for Allergic Contact Dermatitis.
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Pathways for Allergic Contact Dermatitis

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Pathways related to Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 14.04 CXCL8 ICAM1 IFNG IL10 IL17A IL1B
2
ERK Signaling 64
Show member pathways
 13.86 CCL17 CXCL8 CXCR3 IL10 IL17A IL1B
3
PEDF Induced Signaling 64
Show member pathways
 13.71 CCL17 CXCL8 CXCR3 IFNG IL10 IL17A
4
TGF-Beta Pathway 64
Show member pathways
 13.55 CCL17 CXCL8 IFNG IL10 IL17A IL1B
5
Akt Signaling 64
Show member pathways
 13.45 CCL17 CXCL8 CXCR3 IL10 IL17A IL1B
6
Cytokine Signaling in Immune system 66
Show member pathways
 13.4 CXCL8 ICAM1 IFNG IL10 IL17A IL1B
7
PAK Pathway 64
Show member pathways
 13.35 CCL17 CXCL8 CXCR3 IL10 IL17A IL1B
8
Toll-like Receptor Signaling Pathway 37 1
Show member pathways
 12.99 CXCL8 IFNG IL10 IL1B TNF
9
Allograft rejection 1 37
Show member pathways
 12.95 CXCL8 ICAM1 IFNG IL10 IL17A IL1B
10
Influenza A 37
Show member pathways
 12.87 CXCL8 ICAM1 IFNG IL1B IL33 IL4
11
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 66
Show member pathways
 12.79 CXCL8 IFNG IL1B IL33 TNF
12
Regulation of IFNA signaling 66
Show member pathways
 12.71 CXCL8 IFNG IL10 IL17A IL1B IL4
13
NF-kappaB Signaling 4
12.64 IFNG IL10 IL17A IL1B IL4 TNF
14
Immune response IL-23 signaling pathway 22
Show member pathways
 12.63 IFNG IL10 IL17A IL1B TNF
15
Th17 cell differentiation 37
Show member pathways
 12.55 IFNG IL10 IL17A IL1B IL4 IL5
16
T cell receptor signaling pathway 37
Show member pathways
 12.53 IFNG IL10 IL17A IL1B IL4 IL5
17
Immune response Role of DAP12 receptors in NK cells 22
Show member pathways
 12.51 ICAM1 IFNG IL4 TNF
18
Folate Metabolism 1
Show member pathways
 12.41 ICAM1 IFNG IL1B IL4 TNF
19
Th1 Differentiation Pathway 65
Show member pathways
 12.34 IFNG IL10 IL17A IL1B TNF
20
Toxoplasmosis 37
Show member pathways
 12.34 IFNG IL10 IL1B IL4 TNF
21
IL-17 Family Signaling Pathways 65
Show member pathways
 12.34 CCL17 CXCL8 IFNG IL17A IL1B IL4
22
Toll Comparative Pathway 64
Show member pathways
 12.31 CXCL8 IFNG IL1B TNF
23
Tuberculosis 37
12.28 IFNG IL10 IL1B TNF
24
IL-1 Family Signaling Pathways 65
Show member pathways
 12.27 CXCL8 IL1B IL33 TNF
25
Bacterial infections in CF airways 22
Show member pathways
 12.27 CXCL8 IFNG IL1B IL4 TNF
26
C-type lectin receptor signaling pathway 37
Show member pathways
 12.26 CCL17 IL10 IL1B TNF
27
Necroptosis 37
Show member pathways
 12.25 IFNG IL1B IL33 TNF
28
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.22 CXCL8 IL10 IL1B TNF
29
Fluid shear stress and atherosclerosis 37
12.18 ICAM1 IFNG IL1B SELE TNF
30
Immune response IFN gamma signaling pathway 22
Show member pathways
 12.14 CCL17 CXCL8 ICAM1 IFNG IL10 IL17A
31
Spinal Cord Injury 1
12.12 CXCL8 ICAM1 IFNG IL1B IL4 TNF
32
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
12.1 IFNG IL10 IL4 IL5 TNF
33
Interleukin-4 and 13 signaling 66
12.06 CXCL8 ICAM1 IL10 IL17A IL1B IL4
34
TNF signaling pathway 37
12.03 ICAM1 IL1B SELE TNF
35
AGE-RAGE signaling pathway in diabetic complications 37
12.02 CXCL8 ICAM1 IL1B SELE TNF
36
Amoebiasis 37
12 CXCL8 IFNG IL10 IL1B TNF
37
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 65
Show member pathways
 11.98 CCL17 CXCL8 CXCR3
38
Hematopoietic cell lineage 37
11.98 IL1B IL4 IL5 TNF
39
IL12-mediated signaling events 1
Show member pathways
 11.97 IFNG IL1B IL4
40
Rheumatoid arthritis 37
11.97 CXCL8 ICAM1 IFNG IL17A IL1B TNF
41
NF-kappa B signaling pathway 37
11.96 CXCL8 ICAM1 IL1B TNF
42
Senescence and Autophagy in Cancer 1
11.94 CXCL8 IFNG IL1B
43
Glucocorticoid receptor regulatory network 1
11.91 CXCL8 ICAM1 IFNG IL4 IL5 SELE
44
Cytokine production by Th17 cells in CF (Mouse model) 22
Show member pathways
 11.88 CXCL8 ICAM1 IL17A
45
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.88 CXCL8 IFNG IL4 IL5 TNF
46
Pertussis 37
11.86 CXCL8 IL10 IL1B TNF
47
Salmonella infection (KEGG) 37
11.84 CXCL8 IFNG IL1B
48
Dendritic Cells Developmental Lineage Pathway 65
11.84 IFNG IL10 IL1B TNF
49
Lung fibrosis 1
11.8 CXCL8 IL1B IL4 IL5 TNF
50
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.77 CXCL8 ICAM1 IFNG IL1B SELE TNF
Sources

GO Terms for Allergic Contact Dermatitis

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Cellular components related to Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 CCL17 CXCL8 IFNG IL10 IL17A IL1B
2 external side of plasma membrane GO:0009897 9.46 CXCR3 ICAM1 IL17A TNF
3 extracellular space GO:0005615 9.44 CCL17 CXCL8 ICAM1 IFNG IL10 IL17A

Biological processes related to Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

(show all 45)
# Name GO ID Score Top Affiliating Genes
1 leukocyte migration GO:0050900 9.93 ICAM1 IL1B SELE TNF
2 immune response GO:0006955 9.91 CCL17 CXCL8 IFNG IL10 IL17A IL1B
3 cellular response to lipopolysaccharide GO:0071222 9.86 CXCL8 ICAM1 IL10 TNF
4 response to lipopolysaccharide GO:0032496 9.85 CXCL8 ICAM1 IL10 IL1B SELE
5 chemokine-mediated signaling pathway GO:0070098 9.84 CCL17 CXCL8 CXCR3
6 regulation of insulin secretion GO:0050796 9.83 IFNG IL1B TNF
7 positive regulation of DNA binding transcription factor activity GO:0051091 9.83 IL10 IL1B IL5 TNF
8 neutrophil chemotaxis GO:0030593 9.82 CCL17 CXCL8 IL1B
9 inflammatory response GO:0006954 9.81 CCL17 CXCL8 CXCR3 IL10 IL17A IL1B
10 cellular response to interleukin-1 GO:0071347 9.8 CCL17 CXCL8 ICAM1 IL17A
11 calcium-mediated signaling GO:0019722 9.79 CXCL8 CXCR3 SELE
12 positive regulation of interleukin-6 production GO:0032755 9.77 IL1B IL33 TNF
13 extrinsic apoptotic signaling pathway GO:0097191 9.75 IFNG IL33 TNF
14 negative regulation of endothelial cell apoptotic process GO:2000352 9.72 ICAM1 IL10 IL4
15 positive regulation of nitric oxide biosynthetic process GO:0045429 9.71 ICAM1 IFNG IL1B TNF
16 embryonic digestive tract development GO:0048566 9.7 CXCL8 TNF
17 negative regulation of lipid catabolic process GO:0050995 9.69 IL1B TNF
18 leukocyte tethering or rolling GO:0050901 9.69 SELE TNF
19 positive regulation of macrophage activation GO:0043032 9.69 IL10 IL33
20 positive regulation of osteoclast differentiation GO:0045672 9.69 IFNG IL17A TNF
21 negative regulation of growth of symbiont in host GO:0044130 9.68 IL10 TNF
22 response to molecule of bacterial origin GO:0002237 9.68 CXCL8 IL10
23 positive regulation of immunoglobulin secretion GO:0051024 9.67 IL33 IL5
24 positive regulation of podosome assembly GO:0071803 9.67 IL5 TNF
25 positive regulation of interleukin-13 production GO:0032736 9.67 IL33 IL4
26 positive regulation of chemokine biosynthetic process GO:0045080 9.66 IL1B TNF
27 endothelial cell apoptotic process GO:0072577 9.65 IL10 TNF
28 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.65 IFNG IL1B TNF
29 positive regulation of MHC class II biosynthetic process GO:0045348 9.64 IL10 IL4
30 regulation of establishment of endothelial barrier GO:1903140 9.64 IL1B TNF
31 negative regulation of cytokine secretion involved in immune response GO:0002740 9.63 IL10 TNF
32 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.62 ICAM1 TNF
33 positive regulation of fever generation GO:0031622 9.61 IL1B TNF
34 positive regulation of interleukin-23 production GO:0032747 9.61 IFNG IL17A
35 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.61 IL10 IL1B TNF
36 cytokine-mediated signaling pathway GO:0019221 9.61 CXCL8 ICAM1 IL10 IL17A IL1B IL31
37 regulation of isotype switching GO:0045191 9.59 IL10 IL4
38 sequestering of triglyceride GO:0030730 9.58 IL1B TNF
39 receptor biosynthetic process GO:0032800 9.57 IL10 TNF
40 positive regulation of vitamin D biosynthetic process GO:0060557 9.54 IFNG TNF
41 type 2 immune response GO:0042092 9.54 IL10 IL33 IL4
42 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.5 IFNG IL1B TNF
43 regulation of signaling receptor activity GO:0010469 9.36 CCL17 CXCL8 IFNG IL10 IL17A IL1B
44 positive regulation of transcription by RNA polymerase II GO:0045944 10.16 IL10 IL17A IL1B IL33 IL4 TNF
45 positive regulation of transcription, DNA-templated GO:0045893 10.08 IL10 IL1B IL4 IL5 TNF

Molecular functions related to Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.36 CCL17 CXCL8 IFNG IL10 IL17A IL1B
Sources

Sources for Allergic Contact Dermatitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
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51 NDF-RT
54 NINDS
55 Novoseek
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58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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