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MCID: ALL010
MIFTS: 61

Allergic Contact Dermatitis

Categories: Immune diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Allergic Contact Dermatitis

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MalaCards integrated aliases for Allergic Contact Dermatitis:

Name: Allergic Contact Dermatitis 12 38 15 64 17
Dermatitis, Allergic Contact 45 74
Contact Dermatitis, Allergic 77
Dermatitis Allergic Contact 56

Classifications:

MalaCards categories:
Anatomical: Skin diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:3042
KEGG 38 H01357
MeSH 45 D017449
NCIt 51 C26998
UMLS 74 C0162820
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Summaries for Allergic Contact Dermatitis

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PubMed Health : 64 About allergic contact dermatitis: A number of chemical or herbal substances can irritate the skin. Redness, burning or itching are normal skin reactions, for instance, to aggressive cleaning agents.Allergic contact dermatitis (sometimes simply called “contact allergies”) is different, though. Here the immune system overreacts to certain substances – sometimes to very small amounts – that normally wouldn’t cause a reaction. Common examples include certain metals, scents and latex rubber.Contact allergies can lead to severe skin reactions. Unlike with many other kinds of allergies, the reaction doesn’t occur immediately, but after one to three days. And contact allergies develop gradually over a long period of time, as a result of repeated contact with the substance that triggers them. Some people are then no longer able to carry on doing the same kind of work as before.

MalaCards based summary : Allergic Contact Dermatitis, also known as dermatitis, allergic contact, is related to 1,4-phenylenediamine allergic contact dermatitis and nickel allergic contact dermatitis. An important gene associated with Allergic Contact Dermatitis is IL31 (Interleukin 31), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Parthenolide and Hydrocortisone acetate have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and t cells, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Disease Ontology : 12 A contact dermititis that is an allergic skin reaction to foreign chemical or substances leading to red, itchy, weepy reaction where the skin has come into contact with a substance that the immune system recognizes as foreign.

Wikipedia : 77 Allergic contact dermatitis (ACD) is a form of contact dermatitis that is the manifestation of an... more...

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Related Diseases for Allergic Contact Dermatitis

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Diseases related to Allergic Contact Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 409)
# Related Disease Score Top Affiliating Genes
1 1,4-phenylenediamine allergic contact dermatitis 34.8 NAT2 TNF
2 nickel allergic contact dermatitis 34.2 IFNG IL10 IL4 IL5
3 palladium allergic contact dermatitis 34.2 CCL17 IL10 IL17A
4 toxicodendron dermatitis 32.2 CXCL8 ICAM1
5 dermatitis 31.6 CCL17 FLG IFNG IL17A IL31 IL4
6 mycosis fungoides 30.9 CCL17 CXCR3 IL5
7 alopecia areata 30.8 ICAM1 IFNG TNF
8 erythema multiforme 30.7 CCL17 CXCR3 ICAM1 IFNG TNF
9 hypereosinophilic syndrome 30.4 CCL17 IL4 IL5
10 scabies 30.4 CXCL8 IL10
11 ige responsiveness, atopic 30.3 IFNG IL10 IL4 IL5
12 acute generalized exanthematous pustulosis 30.3 CXCL8 IL17A
13 cutaneous t cell lymphoma 30.1 CCL17 IFNG IL4
14 irritant dermatitis 30.1 FLG IL1B TNF
15 discoid lupus erythematosus 30.0 FLG IL10 NAT2
16 actinic prurigo 29.9 ICAM1 IL1B SELE TNF
17 allergic hypersensitivity disease 29.8 CCL17 IFNG IL10 IL4 IL5
18 esophagitis 29.7 CXCL8 IL1B IL5
19 lichen planus 29.7 CXCR3 FLG ICAM1 IFNG IL4 TNF
20 contact dermatitis 29.5 CCL17 CXCL8 CXCR3 FLG ICAM1 IFNG
21 conjunctivitis 29.4 CXCL8 ICAM1 IFNG IL33 IL4 IL5
22 sleep apnea 29.3 CXCL8 ICAM1 IL1B TNF
23 osteomyelitis 29.1 CXCL8 IFNG IL10 IL1B TNF
24 arthritis 28.7 CXCL8 IFNG IL10 IL17A IL1B TNF
25 dermatitis, atopic 28.5 CCL17 CXCL8 FLG ICAM1 IFNG IL10
26 skin disease 27.5 CCL17 CXCL8 FLG ICAM1 IFNG IL10
27 asthma 27.3 CCL17 CXCL8 FLG ICAM1 IFNG IL10
28 chromium allergic contact dermatitis 12.9
29 1-chloro-2,4-dinitrobenzene allergic contact dermatitis 12.8
30 cobalt allergic contact dermatitis 12.8
31 4-tert-butylphenol allergic contact dermatitis 12.7
32 benzo[d]isothiazol-3-one allergic contact dermatitis 12.7
33 diphenylmethane-4,4'-diisocyanate allergic contact dermatitis 12.7
34 benzoic acid allergic contact dermatitis 12.7
35 carvone allergic contact dermatitis 12.7
36 neomycin sulfate allergic contact dermatitis 12.7
37 parthenolide allergic contact dermatitis 12.7
38 formaldehyde allergic contact dermatitis 12.7
39 2,4-dinitrophenyl allergic contact dermatitis 12.7
40 potassium dichromate allergic contact dermatitis 12.6
41 n,n'-diphenylthiourea allergic contact dermatitis 12.6
42 n,n'-diethylthiourea allergic contact dermatitis 12.6
43 allergic contact dermatitis of eyelid 12.4
44 occupational dermatitis 11.7
45 photoallergic dermatitis 11.4
46 psoriasis 10.6
47 urticaria 10.5
48 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 IL5 TNF
49 critical limb ischemia 10.5 SELE TNF
50 mooren's ulcer 10.5 ICAM1 SELE

Graphical network of the top 20 diseases related to Allergic Contact Dermatitis:



Diseases related to Allergic Contact Dermatitis
Sources

Symptoms & Phenotypes for Allergic Contact Dermatitis

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GenomeRNAi Phenotypes related to Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.7 CXCL8 ICAM1 IL10 IL17A IL1B TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.7 CXCL8 ICAM1 IL10 IL17A IL1B TNF

MGI Mouse Phenotypes related to Allergic Contact Dermatitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.15 CCL17 CXCR3 ICAM1 IFNG IL10 IL17A
2 homeostasis/metabolism MP:0005376 10.1 CXCR3 ICAM1 IFNG IL10 IL17A IL1B
3 immune system MP:0005387 10.03 CCL17 CXCR3 ICAM1 IFNG IL10 IL17A
4 digestive/alimentary MP:0005381 10.01 ICAM1 IFNG IL10 IL17A IL33 IL4
5 craniofacial MP:0005382 9.91 IFNG IL10 IL17A IL1B IL4 TNF
6 integument MP:0010771 9.76 ICAM1 IFNG IL10 IL1B IL33 IL4
7 neoplasm MP:0002006 9.5 CXCR3 ICAM1 IFNG IL10 IL1B IL5
8 respiratory system MP:0005388 9.28 CXCR3 IFNG IL10 IL17A IL33 IL4
Sources

Drugs & Therapeutics for Allergic Contact Dermatitis

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PubMedHealth treatment related to Allergic Contact Dermatitis: 64

Allergic skin reactions are usually treated with steroid creams, ointments or solutions.But the main thing to do is avoid contact with the substance that triggers the reaction. Protective gloves and clothing can help here, for instance.A change of career may have to be considered if it isn’t possible to avoid contact with the substance in the workplace. If you are believed to have a work-related contact allergy, it’s a good idea to have your doctor inform your employer’s liability insurance. The insurance will cover certain costs, like the costs of protective measures, if the allergy is recognized as being work-related.

Drugs for Allergic Contact Dermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 122)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Parthenolide Approved, Investigational Phase 4,Phase 2 20554-84-1
2
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
3
Bacitracin Approved, Vet_approved Phase 4,Phase 2 1405-87-4 10909430 439542
4
Bronopol Approved Phase 4 52-51-7
5
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
6
Tacrolimus Approved, Investigational Phase 4 104987-11-3 6473866 445643 439492
7
Povidone Approved Phase 4 9003-39-8
8
Adapalene Approved Phase 4 106685-40-9 60164
9
Benzoyl peroxide Approved Phase 4 94-36-0 7187
10
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
11 sodium thiosulfate Phase 4
12 Dermatologic Agents Phase 4,Phase 3,Phase 1,Not Applicable
13 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 1,Not Applicable
14 Peripheral Nervous System Agents Phase 4,Phase 2,Not Applicable
15 Anti-Infective Agents Phase 4,Phase 3,Phase 2
16 Hydrocortisone-17-butyrate Phase 4
17 Antitubercular Agents Phase 4
18 Analgesics Phase 4,Phase 2,Not Applicable
19 Antirheumatic Agents Phase 4,Phase 2,Not Applicable
20 Analgesics, Non-Narcotic Phase 4,Phase 2,Not Applicable
21 Antioxidants Phase 4
22 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable
23 Antidotes Phase 4
24 Hydrocortisone 17-butyrate 21-propionate Phase 4
25 Anti-Infective Agents, Local Phase 4,Phase 3,Phase 2
26 Protective Agents Phase 4,Not Applicable
27 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Not Applicable
28 Gold Sodium Thiosulfate Phase 4
29 Chelating Agents Phase 4
30 Hydrocortisone hemisuccinate Phase 4
31 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1
32 Antibodies, Monoclonal Phase 4,Phase 3,Phase 1
33 Immunoglobulins Phase 4,Phase 3,Phase 1
34 Antibodies Phase 4,Phase 3,Phase 1
35 Calcineurin Inhibitors Phase 4
36 Immunosuppressive Agents Phase 4,Phase 2
37 Adapalene, Benzoyl Peroxide Drug Combination Phase 4
38 Clindamycin palmitate Phase 4
39 Clindamycin phosphate Phase 4
40
Timolol Approved Phase 3 26839-75-8 5478 33624
41
Petrolatum Approved, Investigational Phase 3,Not Applicable 8009-03-8
42
Sulfadiazine Approved, Investigational, Vet_approved Phase 3 68-35-9 5215
43
Silver sulfadiazine Approved, Vet_approved Phase 3 22199-08-2 441244
44
Maleic acid Experimental, Investigational Phase 3 110-17-8, 110-16-7 444972
45 Pharmaceutical Solutions Phase 3,Phase 1,Phase 2,Not Applicable
46 Adrenergic Agents Phase 3
47 Adrenergic Antagonists Phase 3
48 Antihypertensive Agents Phase 3,Phase 1,Phase 2
49 Anti-Arrhythmia Agents Phase 3
50 Ophthalmic Solutions Phase 3

Interventional clinical trials:

(show top 50) (show all 61)
# Name Status NCT ID Phase Drugs
1 Clinical Evaluation of T.R.U.E. Test Allergens in Children an Adolescents Unknown status NCT01797562 Phase 4 T.R.U.E. Test Panel 3.2
2 Quaternium-15, Use Test Unknown status NCT00311454 Phase 4 T.R.U.E.Test
3 Study of the Safety and Efficacy of Tacrolimus Ointment in Treating Chronic Allergic Contact Dermatitis Completed NCT00667056 Phase 4 tacrolimus ointment;placebo ointment
4 Bioequivalence of Ethylenediamine Dihydrochloride Study Completed NCT01798589 Phase 4 Ethylenediamine dihydrochloride
5 A Comparative Study of the Tolerability of Two Combination Therapies for the Treatment of Acne Completed NCT00887484 Phase 4 BENZOYL PEROXIDE/ CLINDAMYCIN;BENZOYL PEROXIDE/ ADAPALENE
6 A Study to Evaluate Tolerability of Two Topical Drug Products in the Treatment of Facial Acne Completed NCT00964223 Phase 4 Clindamycin and benzoyl peroxide gel (Duac® Topical Gel);benzoyl peroxide and adapalene gel (EPIDUO™ Gel)
7 Clinical Evaluation of T.R.U.E. TEST in Children and Adolescents Completed NCT00795951 Phase 4
8 The Effects of Dupilumab on Allergic Contact Dermatitis Not yet recruiting NCT03935971 Phase 4 Dupilumab
9 Anti-IL-17 a New Treatment for Contact Dermatititis Unknown status NCT02778711 Phase 3 secukinumab
10 Topical Timolol for Superficial Infantile Hemangioma Unknown status NCT01685398 Phase 3 0.5% timolol maleate eye drop;Normal saline
11 A Trial Comparing the Efficacy and Safety of Open Dressing With Petrolatum Jelly vs. Standard Gauze Dressing With Silver Sulfadiazine Completed NCT02109718 Phase 3 Open Dressings with Petrolatum Jelly;Silver Sulfadiazine Gauze Dressing Group
12 Efficacy and Safety Comparing 5% Monoxidil Milky Lotion Versus 5% Minoxidil Solution in Androgenetic Alopecia Unknown status NCT01650272 Phase 1, Phase 2 5% MInoxidil milky lotion;5% Minoxidil solution
13 Clinical Evaluation of the 3 Allergens: Methyldibromoglutharonitrile, Parthenolide and Goldnatriumthiosulphate Completed NCT00133341 Phase 2 Goldnatriomthiosulphate, MDBGN, parthenolide
14 Clinical Evaluation of Bacitracin Completed NCT00132600 Phase 2 bacitracin (allergen)
15 Study of the Intradermal Injection of rHuPH20 or Placebo in Subjects With Nickel Allergic Contact Dermatitis Completed NCT00928447 Phase 2 rHuPH20;Placebo
16 Safety, Tolerability, and Efficacy of 21 Days Dermal Application of MRX-6 on Mild to Moderate Contact Dermatitis Completed NCT00867607 Phase 1, Phase 2 MRX-6;Steroid
17 Study of Apremilast in Atopic or Contact Dermatitis Completed NCT00931242 Phase 2 Apremilast
18 Evaluation of EB01 Cream for the Treatment of Chronic Allergic Contact Dermatitis Not yet recruiting NCT03680131 Phase 2 EB01 Cream Placebo;EB01 Cream 0.2%;EB01 Cream 1.0%;EB01 Cream 2.0%
19 NI-0801 in Allergic Contact Dermatitis Completed NCT01244607 Phase 1 Placebo;NI-0801
20 Immune Response and General Immune Health in Subjects Infected With Herpes Simplex Virus Type 1 (HSV-1) Completed NCT03661541 Phase 1 Squaric Acid Dibutyl Ester
21 CP-481,715 Nickel Allergy Study. Completed NCT00141180 Phase 1 CP-481,715
22 A Study of the Safety, Engraftment, and Action of NB01 in Adults With Moderate Acne Completed NCT03450369 Phase 1
23 Effect of RANKL Inhibition on UV-induced Immunosuppression Completed NCT01978483 Phase 1 Denosumab;Diphenylcyclopropenone;Normal Saline
24 Evaluation of Potential Development of Photoallergic Skin Reaction After Use of MC2-01 Cream Completed NCT03899064 Phase 1 Application of MC2-01 Cream, irradiation;Application of MC2-01 Cream;Applications of MC2-01 vehicle, irradiation;Applications ofh MC2-01 vehicle;Control, irradiation;Control
25 Clinical Evaluation of the Photoallergy Potential of Xenaderm Ointment Completed NCT00645164 Phase 1 Xenaderm
26 NatrOVA Photoallergy Study - NatrOVA Creme Rinse in Healthy Volunteers Completed NCT00605956 Phase 1 NatrOVA Creme Rinse - 1%;NatrOVA Creme Rinse Vehicle Only;Blank Patch
27 Clinical Evaluation of the Photoallergy Potential of Atralin Gel Completed NCT00603772 Phase 1 Atralin (tretinoin) gel, 0.05%
28 Pathophysiological Study of Allergic Contact Dermatitis to Para-Phenylenediamine (PPD). Analysis of Cellular and Molecular Targets in Skin Inflammation Unknown status NCT00445029
29 Nickel Desensitization Using Topical Therapy Unknown status NCT01413477 Not Applicable Calcipotriol, Betamethasone, Calcipotriol & Betamethasone
30 A Randomised Clinical Trial in a Population of Health Care Workers With Hand Eczema Unknown status NCT01012453 Not Applicable
31 Evaluating Results of Regularly Applied Emollient - Spray in Atopic Dermatitis Therapy Unknown status NCT02763722 Not Applicable
32 Red Grape Polyphenol Oral Administration to Women Affected by Nickel-mediated Allergic Contact Dermatitis Completed NCT03902392 Not Applicable
33 Contact Allergies to Dental Metal as a Possible Risk Factor for Oral Cancer Completed NCT00693550
34 Intervention Study to Evaluate the Importance of Information Given to Patients With Contact Allergy Completed NCT01953380 Not Applicable
35 Immune Reactions in Contact Dermatitis Affected Skin Completed NCT01546298
36 Low Dose Exposure to Oxidized R-limonene - A Repeated Open Application Test (ROAT) Study Completed NCT03313232 Not Applicable
37 Evaluating for Contact Allergies in Patients With Chronic Urticaria Completed NCT00868036 Not Applicable
38 Epidemiology and Co-Reactivity of Novel Surfactant Allergens Completed NCT02534441 Not Applicable
39 Short Repeated Nickel Exposures Completed NCT03309215 Not Applicable
40 Evaluation of Tetrix Cream in the Healing of Injured Skin in Subjects With Contact Dermatitis Completed NCT00643214 Not Applicable
41 Human Repeated Insult Patch Test Completed NCT03474874 Not Applicable
42 Cumulative Irritation Patch Test Completed NCT01842711
43 Nickel Allergy and Systemic Nickel Allergy Syndrome in Non Celiac Wheat Sensitivity Completed NCT02750735
44 Safety of a Powder-free Latex Allergy Protocol in the Operating Theatre: A Prospective, Observational Cohort Study Completed NCT02575053
45 Quality of Life Assessment Before and After Essure Removal Completed NCT03401437
46 NeoMatriX Wound Matrix Collagen Dressing Skin Prick Test Completed NCT03522675 Not Applicable
47 To Assess the Photosensitisation and Photoallergy Potential of a Cosmetic Facial Product in Healthy Participants Completed NCT03183518 Not Applicable
48 Human Photoallergy Test (824/2016) Completed NCT02962869 Not Applicable BAY987517
49 To Test for Photo Allergy Reaction of Sunscreens Completed NCT02872220 Not Applicable SPF 50 Y65 110 (BAY987519);SPF 50 Y51 002 (BAY987519);SPF 15 V27 104 (BAY987519);Sodium chloride [NaCl]
50 18349-Human Photoallergy Test Completed NCT02823496 Not Applicable

Search NIH Clinical Center for Allergic Contact Dermatitis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: dermatitis, allergic contact

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Genetic Tests for Allergic Contact Dermatitis

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Anatomical Context for Allergic Contact Dermatitis

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MalaCards organs/tissues related to Allergic Contact Dermatitis:

42
Testes, Skin, T Cells, Eye, Bone, Lung, Lymph Node
Sources

Publications for Allergic Contact Dermatitis

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Articles related to Allergic Contact Dermatitis:

(show top 50) (show all 3023)
# Title Authors Year
1
Blocking type 2 inflammation by dupilumab does not control classic (Type 1-driven) allergic contact dermatitis in chronic hand eczema. ( 30851059 )
2019
2
Lichen sclerosus et atrophicus and allergic contact dermatitis: A significant association. ( 30864217 )
2019
3
Variable impact of dupilumab on patch testing results and allergic contact dermatitis in adults with atopic dermatitis. ( 30885752 )
2019
4
Allergic contact dermatitis caused by phenylbenzimidazole sulfonic acid included in a sunscreen. ( 30891767 )
2019
5
Allergic contact dermatitis to synthetic rubber gloves in healthcare workers: sensitization to 1,3-diphenylguanidine is common. ( 30891769 )
2019
6
Allergic contact dermatitis caused by benzisothiazolinone in a continuous positive airway pressure mask liquid soap. ( 30903668 )
2019
7
Amorphous silicon dioxide nanoparticles modulate immune responses in a model of allergic contact dermatitis. ( 30911099 )
2019
8
Allergic contact dermatitis caused by oxidized linalool in a deodorant. ( 30912148 )
2019
9
Another source of allergic contact dermatitis to isothiazolinones in children - urgent call for regulation. ( 30924553 )
2019
10
Impact of Allergic Contact Dermatitis on the Quality of Life and Work Productivity. ( 30941167 )
2019
11
Allergic contact dermatitis in patients with atopic dermatitis: A retrospective study. ( 30954642 )
2019
12
African blackwood (Dalbergia melanoxylon) induced occupational allergic contact dermatitis in a professional piccolo flautist. ( 30957233 )
2019
13
Airborne allergic contact dermatitis caused by Machaerium scleroxylon: confirmation by in vivo and in vitro tests. ( 30963584 )
2019
14
Occupational Allergic Contact Dermatitis in Thai Spa Therapists. ( 30963587 )
2019
15
CCL2/CCR2 signaling elicits itch- and pain-like behavior in a murine model of allergic contact dermatitis. ( 30981714 )
2019
16
Acetylation Phenotype Variation in Patients with Allergic Contact Dermatitis. ( 30983621 )
2019
17
Patch Testing in Allergic Contact Dermatitis over the Lower Extremities. ( 30983622 )
2019
18
Repeat patch testing in a patient with allergic contact dermatitis improved on dupilumab. ( 30989102 )
2019
19
A case of postoperative bullous allergic contact dermatitis due to injection with lidocaine. ( 31021465 )
2019
20
Qingpeng Ointment Ameliorates Inflammatory Responses and Dysregulation of Itch-Related Molecules for Its Antipruritic Effects in Experimental Allergic Contact Dermatitis. ( 31024317 )
2019
21
Allergic Contact Dermatitis Probably Due to Naftifine Hydrochloride. ( 31045930 )
2019
22
Allergic Contact Dermatitis Due to Benzoyl Peroxide From an Unlikely Source. ( 31045933 )
2019
23
Allergic Contact Dermatitis to Licorice Root Extract. ( 31045935 )
2019
24
Acrylate Allergic Contact Dermatitis-Induced Lichen Planus of the Nail. ( 31045937 )
2019
25
Allergic contact dermatitis related to homemade slime: a case and review of the literature. ( 31046914 )
2019
26
Foot allergic contact dermatitis to mixed dialkyl thioureas. ( 31063241 )
2019
27
A new case of allergic contact dermatitis caused by 3-o-ethyl ascorbic acid in facial antiageing cosmetics. ( 31066077 )
2019
28
Allergic contact dermatitis from ethylhexyl salicylate with possible cross-reactivity to benzyl salicylate. ( 31081128 )
2019
29
Allergic Contact Dermatitis to Shin Pads in a Hockey Player Acetophenone Is an Emerging Allergen. ( 31094944 )
2019
30
Shifting Paradigms in Allergic Contact Dermatitis: The Role of Innate Immunity. ( 31101475 )
2019
31
Dupilumab use in allergic contact dermatitis. ( 30092326 )
2019
32
Allergic contact dermatitis caused by propolis-enriched honey: A case of severe penile oedema. ( 30178472 )
2019
33
Allergic Contact Dermatitis to Kojic Acid. ( 30197046 )
2019
34
A Patch Testing Initiative for the Investigation of Allergic Contact Dermatitis in a UK Allergy Practice: A Retrospective Study. ( 30201159 )
2019
35
Occupational allergic contact dermatitis caused by colophonium. ( 30229960 )
2019
36
Allergic contact dermatitis caused by isopropyl lauroyl sarcosinate. ( 30238468 )
2019
37
Occupational allergic contact dermatitis caused by cobalt in machine oil. ( 30246382 )
2019
38
Peristomal allergic contact dermatitis caused by ostoma pastes and role of Gantrez ES-425. ( 30249081 )
2019
39
"Crossed" allergic contact dermatitis caused by oxidized vitamin K1 in a patient previously sensitized to non-oxidized vitamin K1. ( 30264888 )
2019
40
Isothiazolinone derivatives and allergic contact dermatitis: a review and update. ( 30284765 )
2019
41
Allergic contact dermatitis caused by vinylpyrrolidone/eicosene copolymer in a sunscreen. ( 30304757 )
2019
42
Allergic contact dermatitis caused by Dermabond in a paediatric patient undergoing skin surgery. ( 30304758 )
2019
43
Allergic contact dermatitis caused by clindamycin. ( 30311633 )
2019
44
Allergic contact dermatitis caused by nickel in an eyebrow pencil. ( 30311640 )
2019
45
Allergic contact dermatitis caused by mupirocin and pimecrolimus. ( 30311664 )
2019
46
Allergic contact dermatitis to slime: The epidemic of isothiazolinone allergy encompasses school glue. ( 30318714 )
2019
47
Occupational airborne allergic contact dermatitis caused by N-(4-hydroxyphenyl)benzenesulfonamide. ( 30334269 )
2019
48
Occupational allergic contact dermatitis caused by phenol formaldehyde resin in an interior coating for beverage cans. ( 30350417 )
2019
49
Thiuram allergic contact dermatitis on the hands after skin contact with a rubber cellphone case. ( 30357849 )
2019
50
Allergic contact dermatitis caused by glitter glue used as make-up containing methylchloroisothiazolinone. ( 30407640 )
2019
Sources

Variations for Allergic Contact Dermatitis

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Expression for Allergic Contact Dermatitis

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Search GEO for disease gene expression data for Allergic Contact Dermatitis.
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Pathways for Allergic Contact Dermatitis

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Pathways related to Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 67
Show member pathways
 14.05 CXCL8 ICAM1 IFNG IL10 IL17A IL1B
2
ERK Signaling 65
Show member pathways
 13.86 CCL17 CXCL8 CXCR3 IL10 IL17A IL1B
3
PEDF Induced Signaling 65
Show member pathways
 13.72 CCL17 CXCL8 CXCR3 IFNG IL10 IL17A
4
TGF-Beta Pathway 65
Show member pathways
 13.59 CCL17 CXCL8 ICAM1 IFNG IL10 IL17A
5
Akt Signaling 65
Show member pathways
 13.47 CCL17 CXCL8 CXCR3 IL10 IL17A IL1B
6
Cytokine Signaling in Immune system 67
Show member pathways
 13.42 CXCL8 ICAM1 IFNG IL10 IL17A IL1B
7
PAK Pathway 65
Show member pathways
 13.36 CCL17 CXCL8 CXCR3 IL10 IL17A IL1B
8
Toll-like Receptor Signaling Pathway 1 38
Show member pathways
 13.08 CXCL8 IFNG IL10 IL1B TNF
9
Allograft rejection 38 1
Show member pathways
 12.97 CXCL8 ICAM1 IFNG IL10 IL17A IL1B
10
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 67
Show member pathways
 12.8 CXCL8 IFNG IL1B IL33 TNF
11
Th17 cell differentiation 38
Show member pathways
 12.7 IFNG IL10 IL17A IL1B IL4 IL5
12
T cell receptor signaling pathway 38
Show member pathways
 12.67 IFNG IL10 IL17A IL1B IL4 IL5
13
NF-kappaB Signaling 4
12.65 IFNG IL10 IL17A IL1B IL4 TNF
14
Immune response IL-23 signaling pathway 23
Show member pathways
 12.64 IFNG IL10 IL17A IL1B TNF
15
Immune response Role of DAP12 receptors in NK cells 23
Show member pathways
 12.52 ICAM1 IFNG IL4 TNF
16
Selenium Micronutrient Network 1
Show member pathways
 12.42 ICAM1 IFNG IL1B IL4 TNF
17
JAK-STAT signaling pathway (KEGG) 66
Show member pathways
 12.41 IFNG IL10 IL4 IL5
18
IL-17 Family Signaling Pathways 66
Show member pathways
 12.41 CCL17 CXCL8 IFNG IL17A IL1B IL4
19
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.36 CXCL8 IFNG IL10 IL17A IL1B IL4
20
Toxoplasmosis 38
Show member pathways
 12.35 IFNG IL10 IL1B IL4 TNF
21
Toll Comparative Pathway 65
Show member pathways
 12.33 CXCL8 IFNG IL1B TNF
22
Tuberculosis 38
12.28 IFNG IL10 IL1B TNF
23
Bacterial infections in CF airways 23
Show member pathways
 12.28 CXCL8 IFNG IL1B IL4 TNF
24
IL-1 Family Signaling Pathways 66
Show member pathways
 12.27 CXCL8 IL1B IL33 TNF
25
C-type lectin receptor signaling pathway 38
Show member pathways
 12.26 CCL17 IL10 IL1B TNF
26
Necroptosis 38
Show member pathways
 12.26 IFNG IL1B IL33 TNF
27
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 23
Show member pathways
 12.24 CCL17 CXCL8 CXCR3 ICAM1 IL1B
28
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.23 CXCL8 IL10 IL1B TNF
29
Fluid shear stress and atherosclerosis 38
12.2 ICAM1 IFNG IL1B SELE TNF
30
Th1 Differentiation Pathway 66
Show member pathways
 12.17 IFNG IL10 IL17A IL1B TNF
31
Spinal Cord Injury 1
12.14 CXCL8 ICAM1 IFNG IL1B IL4 TNF
32
Immune response IFN gamma signaling pathway 23
Show member pathways
 12.12 CCL17 CXCL8 ICAM1 IFNG IL10 IL17A
33
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 66
12.11 IFNG IL10 IL4 IL5 TNF
34
Microglia Activation During Neuroinflammation: Overview 66
Show member pathways
 12.1 IFNG IL1B IL4 TNF
35
Interleukin-4 and 13 signaling 67
12.1 CXCL8 ICAM1 IL10 IL17A IL1B IL4
36
TNF signaling pathway 38
12.04 ICAM1 IL1B SELE TNF
37
AGE-RAGE signaling pathway in diabetic complications 38
12.04 CXCL8 ICAM1 IL1B SELE TNF
38
Amoebiasis 38
12.01 CXCL8 IFNG IL10 IL1B TNF
39
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 66
Show member pathways
 11.99 CCL17 CXCL8 CXCR3
40
NF-kappa B signaling pathway 38
11.99 CXCL8 ICAM1 IL1B TNF
41
Rheumatoid arthritis 38
11.99 CXCL8 ICAM1 IFNG IL17A IL1B TNF
42
IL12-mediated signaling events 1
Show member pathways
 11.98 IFNG IL1B IL4
43
Hematopoietic cell lineage 38
11.98 IL1B IL4 IL5 TNF
44
Senescence and Autophagy in Cancer 1
11.95 CXCL8 IFNG IL1B
45
Glucocorticoid receptor regulatory network 1
11.93 CXCL8 ICAM1 IFNG IL4 IL5 SELE
46
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.9 CXCL8 IFNG IL4 IL5 TNF
47
Cytokine production by Th17 cells in CF (Mouse model) 23
Show member pathways
 11.89 CXCL8 ICAM1 IL17A
48
Pertussis 38
11.86 CXCL8 IL10 IL1B TNF
49
Salmonella infection (KEGG) 38
11.85 CXCL8 IFNG IL1B
50
Dendritic Cells Developmental Lineage Pathway 66
11.85 IFNG IL10 IL1B TNF
Sources

GO Terms for Allergic Contact Dermatitis

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Cellular components related to Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 CCL17 CXCL8 IFNG IL10 IL17A IL1B
2 external side of plasma membrane GO:0009897 9.46 CXCR3 ICAM1 IL17A TNF
3 extracellular space GO:0005615 9.44 CCL17 CXCL8 ICAM1 IFNG IL10 IL17A

Biological processes related to Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Name GO ID Score Top Affiliating Genes
1 leukocyte migration GO:0050900 9.93 ICAM1 IL1B SELE TNF
2 response to lipopolysaccharide GO:0032496 9.91 ICAM1 IL10 IL1B SELE
3 inflammatory response GO:0006954 9.91 CCL17 CXCL8 CXCR3 IL10 IL17A IL1B
4 calcium-mediated signaling GO:0019722 9.86 CXCL8 CXCR3 SELE
5 neutrophil chemotaxis GO:0030593 9.85 CCL17 CXCL8 IL1B
6 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.85 CCL17 ICAM1 TNF
7 chemokine-mediated signaling pathway GO:0070098 9.85 CCL17 CXCL8 CXCR3
8 immune response GO:0006955 9.85 CCL17 CXCL8 CXCR3 IFNG IL10 IL17A
9 regulation of insulin secretion GO:0050796 9.83 IFNG IL1B TNF
10 positive regulation of DNA-binding transcription factor activity GO:0051091 9.83 IL10 IL1B IL5 TNF
11 cellular response to lipopolysaccharide GO:0071222 9.83 CXCL8 ICAM1 IL10 IL1B TNF
12 positive regulation of interleukin-6 production GO:0032755 9.82 IL1B IL33 TNF
13 cellular response to interleukin-1 GO:0071347 9.8 CCL17 CXCL8 ICAM1 IL17A
14 extrinsic apoptotic signaling pathway GO:0097191 9.77 IFNG IL33 TNF
15 negative regulation of endothelial cell apoptotic process GO:2000352 9.72 ICAM1 IL10 IL4
16 negative regulation of lipid catabolic process GO:0050995 9.71 IL1B TNF
17 positive regulation of glial cell proliferation GO:0060252 9.71 IL1B TNF
18 positive regulation of macrophage activation GO:0043032 9.71 IL10 IL33
19 positive regulation of nitric oxide biosynthetic process GO:0045429 9.71 ICAM1 IFNG IL1B TNF
20 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.7 IL1B TNF
21 negative regulation of growth of symbiont in host GO:0044130 9.7 IL10 TNF
22 positive regulation of immunoglobulin secretion GO:0051024 9.69 IL33 IL5
23 positive regulation of podosome assembly GO:0071803 9.69 IL5 TNF
24 response to molecule of bacterial origin GO:0002237 9.69 CXCL8 IL10
25 positive regulation of osteoclast differentiation GO:0045672 9.69 IFNG IL17A TNF
26 positive regulation of chemokine secretion GO:0090197 9.68 IL33 TNF
27 positive regulation of interleukin-13 production GO:0032736 9.68 IL33 IL4
28 endothelial cell apoptotic process GO:0072577 9.67 IL10 TNF
29 positive regulation of chemokine biosynthetic process GO:0045080 9.66 IL1B TNF
30 response to glucocorticoid GO:0051384 9.65 IL10 TNF
31 positive regulation of MHC class II biosynthetic process GO:0045348 9.65 IL10 IL4
32 regulation of establishment of endothelial barrier GO:1903140 9.65 IL1B TNF
33 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.65 IFNG IL1B TNF
34 negative regulation of cytokine secretion involved in immune response GO:0002740 9.64 IL10 TNF
35 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.63 ICAM1 TNF
36 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.63 IL10 IL1B TNF
37 positive regulation of fever generation GO:0031622 9.62 IL1B TNF
38 positive regulation of interleukin-23 production GO:0032747 9.61 IFNG IL17A
39 cytokine-mediated signaling pathway GO:0019221 9.61 CXCL8 ICAM1 IL10 IL17A IL1B IL31
40 regulation of isotype switching GO:0045191 9.58 IL10 IL4
41 sequestering of triglyceride GO:0030730 9.58 IL1B TNF
42 type 2 immune response GO:0042092 9.57 IL10 IL4
43 receptor biosynthetic process GO:0032800 9.56 IL10 TNF
44 positive regulation of vitamin D biosynthetic process GO:0060557 9.54 IFNG TNF
45 positive regulation of neuroinflammatory response GO:0150078 9.54 IL1B IL33 TNF
46 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.5 IFNG IL1B TNF
47 regulation of signaling receptor activity GO:0010469 9.36 CCL17 CXCL8 IFNG IL10 IL17A IL1B
48 chronic inflammatory response to antigenic stimulus GO:0002439 9.29 TNF
49 positive regulation of transcription by RNA polymerase II GO:0045944 10.18 IL10 IL17A IL1B IL33 IL4 TNF
50 positive regulation of transcription, DNA-templated GO:0045893 10.09 IL10 IL1B IL4 IL5 TNF

Molecular functions related to Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.8 CCL17 CXCL8 FLG ICAM1 IFNG IL10
2 cytokine activity GO:0005125 9.36 CCL17 CXCL8 IFNG IL10 IL17A IL1B
Sources

Sources for Allergic Contact Dermatitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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