MCID: ALL010
MIFTS: 59

Allergic Contact Dermatitis

Categories: Immune diseases, Skin diseases

Aliases & Classifications for Allergic Contact Dermatitis

Summaries for Allergic Contact Dermatitis

PubMed Health : 63 About allergic contact dermatitis: A number of chemical or herbal substances can irritate the skin. Redness, burning or itching are normal skin reactions, for instance, to aggressive cleaning agents.Allergic contact dermatitis (sometimes simply called “contact allergies”) is different, though. Here the immune system overreacts to certain substances – sometimes to very small amounts – that normally wouldn’t cause a reaction. Common examples include certain metals, scents and latex rubber.Contact allergies can lead to severe skin reactions. Unlike with many other kinds of allergies, the reaction doesn’t occur immediately, but after one to three days. And contact allergies develop gradually over a long period of time, as a result of repeated contact with the substance that triggers them. Some people are then no longer able to carry on doing the same kind of work as before.

MalaCards based summary : Allergic Contact Dermatitis, also known as dermatitis, allergic contact, is related to 1,4-phenylenediamine allergic contact dermatitis and nickel allergic contact dermatitis. An important gene associated with Allergic Contact Dermatitis is IL31 (Interleukin 31), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Bacitracin and Bronopol have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and t cells, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Disease Ontology : 12 A contact dermititis that is an allergic skin reaction to foreign chemical or substances leading to red, itchy, weepy reaction where the skin has come into contact with a substance that the immune system recognizes as foreign.

Wikipedia : 76 Allergic contact dermatitis (ACD) is a form of contact dermatitis that is the manifestation of an... more...

Related Diseases for Allergic Contact Dermatitis

Diseases related to Allergic Contact Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 390)
# Related Disease Score Top Affiliating Genes
1 1,4-phenylenediamine allergic contact dermatitis 34.5 NAT2 TNF
2 nickel allergic contact dermatitis 34.2 IFNG IL10 IL4 IL5
3 palladium allergic contact dermatitis 34.1 CCL17 IL10 IL17A
4 dermatitis 31.6 CCL17 FLG IFNG IL17A IL31 IL4
5 erythema multiforme 30.7 CCL17 CXCR3 ICAM1 IFNG TNF
6 scabies 30.3 CXCL8 IL10
7 contact dermatitis 30.3 CCL17 CXCL8 CXCR3 FLG ICAM1 IFNG
8 acute generalized exanthematous pustulosis 30.2 CXCL8 IL17A
9 irritant dermatitis 30.1 FLG IL1B TNF
10 cutaneous t cell lymphoma 30.1 CCL17 IFNG IL4
11 discoid lupus erythematosus 30.0 FLG IL10 NAT2
12 actinic prurigo 29.9 ICAM1 IL1B SELE TNF
13 ige responsiveness, atopic 29.8 IFNG IL10 IL4 IL5
14 allergic hypersensitivity disease 29.7 CCL17 IFNG IL10 IL4 IL5
15 alopecia areata 29.6 ICAM1 IFNG IL17A IL1B TNF
16 lichen planus 29.5 CXCR3 FLG ICAM1 IFNG IL4 TNF
17 dermatitis, atopic 29.1 CCL17 CXCL8 CXCR3 FLG ICAM1 IFNG
18 psoriasis 28.9 CCL17 CXCL8 CXCR3 FLG ICAM1 IFNG
19 skin disease 28.2 CCL17 CXCL8 FLG ICAM1 IFNG IL10
20 asthma 27.9 CCL17 CXCL8 FLG ICAM1 IFNG IL10
21 chromium allergic contact dermatitis 12.7
22 cobalt allergic contact dermatitis 12.7
23 1-chloro-2,4-dinitrobenzene allergic contact dermatitis 12.7
24 4-tert-butylphenol allergic contact dermatitis 12.6
25 benzo[d]isothiazol-3-one allergic contact dermatitis 12.6
26 diphenylmethane-4,4'-diisocyanate allergic contact dermatitis 12.6
27 benzoic acid allergic contact dermatitis 12.6
28 carvone allergic contact dermatitis 12.6
29 neomycin sulfate allergic contact dermatitis 12.6
30 parthenolide allergic contact dermatitis 12.6
31 formaldehyde allergic contact dermatitis 12.6
32 2,4-dinitrophenyl allergic contact dermatitis 12.6
33 potassium dichromate allergic contact dermatitis 12.6
34 n,n'-diphenylthiourea allergic contact dermatitis 12.6
35 n,n'-diethylthiourea allergic contact dermatitis 12.6
36 allergic contact dermatitis of eyelid 12.3
37 occupational dermatitis 11.7
38 photoallergic dermatitis 11.2
39 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 IL5 TNF
40 critical limb ischemia 10.3 SELE TNF
41 mooren's ulcer 10.3 ICAM1 SELE
42 heterophyiasis 10.3 ICAM1 SELE
43 lymphocytic vasculitis 10.3 ICAM1 SELE
44 angioedema 10.3
45 rosacea 10.3
46 eosinophilic fasciitis 10.3 IFNG IL5
47 chronic beryllium disease 10.3 IFNG TNF
48 transient hypogammaglobulinemia 10.3 IL10 TNF
49 microscopic polyangiitis 10.3 IL10 TNF
50 multifocal choroiditis 10.3 IL10 TNF

Graphical network of the top 20 diseases related to Allergic Contact Dermatitis:



Diseases related to Allergic Contact Dermatitis

Symptoms & Phenotypes for Allergic Contact Dermatitis

GenomeRNAi Phenotypes related to Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.7 CXCL8 ICAM1 IL10 IL17A IL1B TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.7 CXCL8 ICAM1 IL10 IL17A IL1B TNF

MGI Mouse Phenotypes related to Allergic Contact Dermatitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.15 CCL17 CXCR3 ICAM1 IFNG IL10 IL17A
2 homeostasis/metabolism MP:0005376 10.1 CXCR3 ICAM1 IFNG IL10 IL17A IL1B
3 immune system MP:0005387 10.03 CCL17 CXCR3 ICAM1 IFNG IL10 IL17A
4 digestive/alimentary MP:0005381 10.01 ICAM1 IFNG IL10 IL17A IL33 IL4
5 craniofacial MP:0005382 9.91 IFNG IL10 IL17A IL1B IL4 TNF
6 integument MP:0010771 9.76 ICAM1 IFNG IL10 IL1B IL33 IL4
7 neoplasm MP:0002006 9.5 CXCR3 ICAM1 IFNG IL10 IL1B IL5
8 respiratory system MP:0005388 9.28 CXCR3 IFNG IL10 IL17A IL33 IL4

Drugs & Therapeutics for Allergic Contact Dermatitis

PubMedHealth treatment related to Allergic Contact Dermatitis: 63

Allergic skin reactions are usually treated with steroid creams, ointments or solutions.But the main thing to do is avoid contact with the substance that triggers the reaction. Protective gloves and clothing can help here, for instance.A change of career may have to be considered if it isn’t possible to avoid contact with the substance in the workplace. If you are believed to have a work-related contact allergy, it’s a good idea to have your doctor inform your employer’s liability insurance. The insurance will cover certain costs, like the costs of protective measures, if the allergy is recognized as being work-related.

Drugs for Allergic Contact Dermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 90)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bacitracin Approved, Vet_approved Phase 4,Phase 2 1405-87-4 10909430 439542
2
Bronopol Approved Phase 4 52-51-7
3 Parthenolide Approved, Investigational Phase 4,Phase 2 20554-84-1
4
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
5
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
6
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
7
Povidone Approved Phase 4 9003-39-8
8
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
9
Benzoyl peroxide Approved Phase 4 94-36-0 7187
10
Adapalene Approved Phase 4 106685-40-9 60164
11 sodium thiosulfate Phase 4
12 Antirheumatic Agents Phase 4,Phase 2
13 Analgesics, Non-Narcotic Phase 4,Phase 2
14 Cortisol succinate Phase 4
15 Gold Sodium Thiosulfate Phase 4
16 Dermatologic Agents Phase 4,Phase 3,Not Applicable
17 Hydrocortisone 17-butyrate 21-propionate Phase 4
18 Hydrocortisone-17-butyrate Phase 4
19 Antioxidants Phase 4
20 Anti-Infective Agents, Local Phase 4,Phase 3,Phase 2
21 Antidotes Phase 4
22 Antitubercular Agents Phase 4
23 Anti-Inflammatory Agents Phase 4,Phase 2,Not Applicable
24 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2
25 Anti-Bacterial Agents Phase 4,Phase 2,Not Applicable
26 Analgesics Phase 4,Phase 2
27 Anti-Infective Agents Phase 4,Phase 3,Phase 2
28 Chelating Agents Phase 4
29 Peripheral Nervous System Agents Phase 4,Phase 2
30 Protective Agents Phase 4
31 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1
32 Calcineurin Inhibitors Phase 4
33 Immunosuppressive Agents Phase 4,Phase 2
34 Clindamycin palmitate Phase 4
35 Adapalene, Benzoyl Peroxide Drug Combination Phase 4
36 Clindamycin phosphate Phase 4
37
Timolol Approved Phase 3 26839-75-8 33624 5478
38
Petrolatum Approved, Investigational Phase 3,Not Applicable 8009-03-8
39
Silver sulfadiazine Approved, Vet_approved Phase 3 22199-08-2 441244
40
Sulfadiazine Approved, Investigational, Vet_approved Phase 3 68-35-9 5215
41
Maleic acid Experimental Phase 3 110-16-7 444266
42 Immunoglobulins Phase 3
43 Antibodies, Monoclonal Phase 3
44 Antibodies Phase 3
45 Ophthalmic Solutions Phase 3
46 Neurotransmitter Agents Phase 3
47 Antihypertensive Agents Phase 3,Phase 1,Phase 2
48 Adrenergic Antagonists Phase 3
49 Adrenergic beta-Antagonists Phase 3
50 Pharmaceutical Solutions Phase 3,Phase 1,Phase 2

Interventional clinical trials:

(show all 40)
# Name Status NCT ID Phase Drugs
1 Clinical Evaluation of T.R.U.E. Test Allergens in Children an Adolescents Unknown status NCT01797562 Phase 4 T.R.U.E. Test Panel 3.2
2 Quaternium-15, Use Test Unknown status NCT00311454 Phase 4 T.R.U.E.Test
3 Study of the Safety and Efficacy of Tacrolimus Ointment in Treating Chronic Allergic Contact Dermatitis Completed NCT00667056 Phase 4 tacrolimus ointment;placebo ointment
4 Bioequivalence of Ethylenediamine Dihydrochloride Study Completed NCT01798589 Phase 4 Ethylenediamine dihydrochloride
5 A Comparative Study of the Tolerability of Two Combination Therapies for the Treatment of Acne Completed NCT00887484 Phase 4 BENZOYL PEROXIDE/ CLINDAMYCIN;BENZOYL PEROXIDE/ ADAPALENE
6 A Study to Evaluate Tolerability of Two Topical Drug Products in the Treatment of Facial Acne Completed NCT00964223 Phase 4 Clindamycin and benzoyl peroxide gel (Duac® Topical Gel);benzoyl peroxide and adapalene gel (EPIDUO™ Gel)
7 Clinical Evaluation of T.R.U.E. TEST in Children and Adolescents Completed NCT00795951 Phase 4
8 Anti-IL-17 a New Treatment for Contact Dermatititis Unknown status NCT02778711 Phase 3 secukinumab
9 Topical Timolol for Superficial Infantile Hemangioma Unknown status NCT01685398 Phase 3 0.5% timolol maleate eye drop;Normal saline
10 A Trial Comparing the Efficacy and Safety of Open Dressing With Petrolatum Jelly vs. Standard Gauze Dressing With Silver Sulfadiazine Completed NCT02109718 Phase 3 Open Dressings with Petrolatum Jelly;Silver Sulfadiazine Gauze Dressing Group
11 Efficacy and Safety Comparing 5% Monoxidil Milky Lotion Versus 5% Minoxidil Solution in Androgenetic Alopecia Unknown status NCT01650272 Phase 1, Phase 2 5% MInoxidil milky lotion;5% Minoxidil solution
12 Clinical Evaluation of the 3 Allergens: Methyldibromoglutharonitrile, Parthenolide and Goldnatriumthiosulphate Completed NCT00133341 Phase 2 Goldnatriomthiosulphate, MDBGN, parthenolide
13 Clinical Evaluation of Bacitracin Completed NCT00132600 Phase 2 bacitracin (allergen)
14 Study of the Intradermal Injection of rHuPH20 or Placebo in Subjects With Nickel Allergic Contact Dermatitis Completed NCT00928447 Phase 2 rHuPH20;Placebo
15 Safety, Tolerability, and Efficacy of 21 Days Dermal Application of MRX-6 on Mild to Moderate Contact Dermatitis Completed NCT00867607 Phase 1, Phase 2 MRX-6;Steroid
16 Study of Apremilast in Atopic or Contact Dermatitis Completed NCT00931242 Phase 2 Apremilast
17 Evaluation of EB01 Cream for the Treatment of Chronic Allergic Contact Dermatitis Not yet recruiting NCT03680131 Phase 2 EB01 Cream Placebo;EB01 Cream 0.2%;EB01 Cream 1.0%;EB01 Cream 2.0%
18 NI-0801 in Allergic Contact Dermatitis Completed NCT01244607 Phase 1 Placebo;NI-0801
19 Immune Response and General Immune Health in Subjects Infected With Herpes Simplex Virus Type 1 (HSV-1) Completed NCT03661541 Phase 1 Squaric Acid Dibutyl Ester
20 CP-481,715 Nickel Allergy Study. Completed NCT00141180 Phase 1 CP-481,715
21 A Study of the Safety, Engraftment, and Action of NB01 in Adults With Moderate Acne Completed NCT03450369 Phase 1
22 Pathophysiological Study of Allergic Contact Dermatitis to Para-Phenylenediamine (PPD). Analysis of Cellular and Molecular Targets in Skin Inflammation Unknown status NCT00445029
23 Nickel Desensitization Using Topical Therapy Unknown status NCT01413477 Not Applicable Calcipotriol, Betamethasone, Calcipotriol & Betamethasone
24 A Randomised Clinical Trial in a Population of Health Care Workers With Hand Eczema Unknown status NCT01012453 Not Applicable
25 Evaluating Results of Regularly Applied Emollient - Spray in Atopic Dermatitis Therapy Unknown status NCT02763722 Not Applicable
26 Contact Allergies to Dental Metal as a Possible Risk Factor for Oral Cancer Completed NCT00693550
27 Intervention Study to Evaluate the Importance of Information Given to Patients With Contact Allergy Completed NCT01953380 Not Applicable
28 Immune Reactions in Contact Dermatitis Affected Skin Completed NCT01546298
29 Low Dose Exposure to Oxidized R-limonene - A Repeated Open Application Test (ROAT) Study Completed NCT03313232 Not Applicable
30 Evaluating for Contact Allergies in Patients With Chronic Urticaria Completed NCT00868036 Not Applicable
31 Epidemiology and Co-Reactivity of Novel Surfactant Allergens Completed NCT02534441 Not Applicable
32 Short Repeated Nickel Exposures Completed NCT03309215 Not Applicable
33 Evaluation of Tetrix Cream in the Healing of Injured Skin in Subjects With Contact Dermatitis Completed NCT00643214 Not Applicable
34 Cumulative Irritation Patch Test Completed NCT01842711
35 Nickel Allergy and Systemic Nickel Allergy Syndrome in Non Celiac Wheat Sensitivity Completed NCT02750735
36 Safety of a Powder-free Latex Allergy Protocol in the Operating Theatre: A Prospective, Observational Cohort Study Completed NCT02575053
37 Quality of Life Assessment Before and After Essure Removal Completed NCT03401437
38 Improving Value of Care for Patients With Severe Stasis Dermatitis Recruiting NCT03022786 Not Applicable
39 Cutaneous and Systemic Reactions to Metal Implants Recruiting NCT02483728 Not Applicable
40 Metal Allergy In-Stent Restenosis Study Not yet recruiting NCT03588962 Not Applicable

Search NIH Clinical Center for Allergic Contact Dermatitis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: dermatitis, allergic contact

Genetic Tests for Allergic Contact Dermatitis

Anatomical Context for Allergic Contact Dermatitis

MalaCards organs/tissues related to Allergic Contact Dermatitis:

41
Skin, Testes, T Cells, Eye, Bone, Lung, Heart

Publications for Allergic Contact Dermatitis

Articles related to Allergic Contact Dermatitis:

(show top 50) (show all 1133)
# Title Authors Year
1
Occupational allergic contact dermatitis caused by colophonium. ( 30229960 )
2019
2
Allergic contact dermatitis caused by isopropyl lauroyl sarcosinate. ( 30238468 )
2019
3
Occupational allergic contact dermatitis caused by cobalt in machine oil. ( 30246382 )
2019
4
"Crossed" allergic contact dermatitis caused by oxidized vitamin K1 in a patient previously sensitized to non-oxidized vitamin K1. ( 30264888 )
2019
5
Allergic contact dermatitis caused by vinylpyrrolidone/eicosene copolymer in a sunscreen. ( 30304757 )
2019
6
Allergic contact dermatitis caused by Dermabond in a paediatric patient undergoing skin surgery. ( 30304758 )
2019
7
Allergic contact dermatitis caused by clindamycin. ( 30311633 )
2019
8
Occupational airborne allergic contact dermatitis caused by N-(4-hydroxyphenyl)benzenesulfonamide. ( 30334269 )
2019
9
Tertiary prevention of occupational skin diseases: Prevalence of allergic contact dermatitis and pattern of patch test results. ( 30506828 )
2019
10
Allergic contact dermatitis caused by octylisothiazolinone in a leather sofa. ( 29790173 )
2018
11
Chemokine Signaling in Allergic Contact Dermatitis: Toward Targeted Therapies. ( 29939854 )
2018
12
Allergic contact dermatitis caused by acrylic-based medical dressings and adhesives. ( 29888412 )
2018
13
Declining prevalence of allergic contact dermatitis caused by tosylamide formaldehyde resin in nail polish. ( 29726606 )
2018
14
Allergic contact dermatitis resulting from cetyl PEG/PPG-10/1 dimethicone in a deodorant cream. ( 29430705 )
2018
15
Pediatric "pet consort dermatitis"-Allergic contact dermatitis from transfer of bronopol from a pet cat. ( 29943851 )
2018
16
Allergic contact dermatitis caused by hydroxyacetophenone in a face cream. ( 29341188 )
2018
17
Allergic contact dermatitis caused by triethylenetetramine: the glue is the clue. ( 29392782 )
2018
18
Glove-Related Allergic Contact Dermatitis. ( 29901500 )
2018
19
Kumkum-induced allergic contact dermatitis: Are we missing the actual culprit? ( 29393081 )
2018
20
Occupational allergic contact dermatitis caused by antibiotics in healthcare workersA -A relationship with non-immediate drug eruptions. ( 29399806 )
2018
21
Involvement of the Negative Feedback of IL-33 Signaling in the Anti-Inflammatory Effect of Electro-acupuncture on Allergic Contact Dermatitis via Targeting MicroRNA-155 in Mast Cells. ( 29404871 )
2018
22
Chromium(III) release from chromium-tanned leather elicits allergic contact dermatitis: a use test study. ( 29322530 )
2018
23
Silkworm dropping extract ameliorate trimellitic anhydride-induced allergic contact dermatitis by regulating Th1/Th2 immune response. ( 29806566 )
2018
24
Short contact with nickel causes allergic contact dermatitis: an experimental study. ( 29959775 )
2018
25
Severe allergic contact dermatitis mimicking angioedema caused by propolis used as a traditional remedy. ( 29845630 )
2018
26
Allergic contact dermatitis caused by benzyl salicylate in hair products. ( 29943414 )
2018
27
Contact Buzz: Allergic Contact Dermatitis to Cannabis. ( 29933254 )
2018
28
A case of allergic contact dermatitis caused by Disperse Blue dye in ultrasound gel. ( 29766523 )
2018
29
Relapsing polyisoprene glove allergic contact dermatitis: Another call for more complete glove package label declaration. ( 29785753 )
2018
30
First report of allergic contact dermatitis caused by sorbitan caprylate. ( 29341184 )
2018
31
Occupational allergic contact dermatitis caused by nickel in embroidery needles. ( 29781177 )
2018
32
Allergic contact dermatitis from formaldehyde mimicking impetigo and initiating rosacea. ( 29611264 )
2018
33
Innate immunity and effector and regulatory mechanisms involved in allergic contact dermatitis. ( 29723367 )
2018
34
Possible role of regional variation in allergic contact dermatitis: case report. ( 29430710 )
2018
35
Anti-pruritic and anti-inflammatory effects of oxymatrine in a mouse model of allergic contact dermatitis. ( 29903654 )
2018
36
A novel case of a brush with discomfort: allergic contact dermatitis caused by mercaptobenzothiazole in rubber components of a toothbrush. ( 29446120 )
2018
37
Allergic contact dermatitis caused by Solvent Orange 60 in spectacle frames in Japan. ( 29265444 )
2018
38
Non-occupational allergic contact dermatitis caused by long-lasting nail polish kits for home use: 'the tip of the iceberg'. ( 29327355 )
2018
39
Systemic allergic contact dermatitis associated with topical diltiazem and/or cinchocaine. ( 29423962 )
2018
40
Lymphocyte surface markers and cytokines are suitable for detection and potency assessment of skin-sensitizing chemicals in an in vitro model of allergic contact dermatitis: the LCSA-ly. ( 29380012 )
2018
41
Allergic contact dermatitis caused by a polyurethane catheter. ( 29923607 )
2018
42
Allergic contact dermatitis caused by topical ketoconazole: a relevant issue? Review of ketoconazole-positive patch tests. ( 29430708 )
2018
43
Allergic contact dermatitis caused by plastic items containing the ultraviolet absorber drometrizole. ( 29761506 )
2018
44
Allergic contact dermatitis caused by OlanedineAr (olanexidine gluconate), a new antiseptic. ( 29341182 )
2018
45
A private case of allergic contact dermatitis. ( 29341989 )
2018
46
Allergic Contact Dermatitis-Induced Stereospecificity Overview. ( 29933255 )
2018
47
IL-26 in allergic contact dermatitis: Resource in a state of readiness. ( 29498775 )
2018
48
The Anti-Inflammatory Effect of Fructus Kochiae on Allergic Contact Dermatitis Rats via pERK1/2/TLR4/NF-κB Pathway Activation. ( 29507585 )
2018
49
Eucalyptus species as a cause of airborne allergic contact dermatitis. ( 29527731 )
2018
50
Further Evidence of Severe Allergic Contact Dermatitis From Isobornyl Acrylate While Using a Continuous Glucose Monitoring System. ( 29542347 )
2018

Variations for Allergic Contact Dermatitis

Expression for Allergic Contact Dermatitis

Search GEO for disease gene expression data for Allergic Contact Dermatitis.

Pathways for Allergic Contact Dermatitis

Pathways related to Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.05 CXCL8 ICAM1 IFNG IL10 IL17A IL1B
2
Show member pathways
13.86 CCL17 CXCL8 CXCR3 IL10 IL17A IL1B
3
Show member pathways
13.72 CCL17 CXCL8 CXCR3 IFNG IL10 IL17A
4
Show member pathways
13.59 CCL17 CXCL8 ICAM1 IFNG IL10 IL17A
5
Show member pathways
13.47 CCL17 CXCL8 CXCR3 IL10 IL17A IL1B
6
Show member pathways
13.42 CXCL8 ICAM1 IFNG IL10 IL17A IL1B
7
Show member pathways
13.36 CCL17 CXCL8 CXCR3 IL10 IL17A IL1B
8
Show member pathways
13 CXCL8 IFNG IL10 IL1B TNF
9
Show member pathways
12.97 CXCL8 ICAM1 IFNG IL10 IL17A IL1B
10
Show member pathways
12.88 CXCL8 ICAM1 IFNG IL1B IL33 IL4
11
Show member pathways
12.8 CXCL8 IFNG IL1B IL33 TNF
12
Show member pathways
12.7 IFNG IL10 IL17A IL1B IL4 IL5
13 12.66 IFNG IL10 IL17A IL1B IL4 TNF
14
Show member pathways
12.64 IFNG IL10 IL17A IL1B TNF
15
Show member pathways
12.54 IFNG IL10 IL17A IL1B IL4 IL5
16
Show member pathways
12.52 ICAM1 IFNG IL4 TNF
17
Show member pathways
12.42 ICAM1 IFNG IL1B IL4 TNF
18
Show member pathways
12.41 IFNG IL10 IL4 IL5
19
Show member pathways
12.41 CCL17 CXCL8 IFNG IL17A IL1B IL4
20
Show member pathways
12.36 CXCL8 IFNG IL10 IL17A IL1B IL4
21
Show member pathways
12.35 IFNG IL10 IL1B IL4 TNF
22
Show member pathways
12.33 CXCL8 IFNG IL1B TNF
23
Show member pathways
12.29 CXCL8 IFNG IL1B IL4 TNF
24 12.28 IFNG IL10 IL1B TNF
25
Show member pathways
12.28 CXCL8 IL1B IL33 TNF
26
Show member pathways
12.26 CCL17 IL10 IL1B TNF
27
Show member pathways
12.26 IFNG IL1B IL33 TNF
28
Show member pathways
12.24 CCL17 CXCL8 CXCR3 ICAM1 IL1B
29 12.23 CXCL8 IL10 IL1B TNF
30 12.2 ICAM1 IFNG IL1B SELE TNF
31
Show member pathways
12.17 IFNG IL10 IL17A IL1B TNF
32 12.14 CXCL8 ICAM1 IFNG IL1B IL4 TNF
33
Show member pathways
12.12 CCL17 CXCL8 ICAM1 IFNG IL10 IL17A
34 12.11 IFNG IL10 IL4 IL5 TNF
35
Show member pathways
12.1 IFNG IL1B IL4 TNF
36 12.1 CXCL8 ICAM1 IL10 IL17A IL1B IL4
37 12.04 ICAM1 IL1B SELE TNF
38 12.03 CXCL8 ICAM1 IL1B SELE TNF
39 12.01 CXCL8 IFNG IL10 IL1B TNF
40
Show member pathways
11.99 CCL17 CXCL8 CXCR3
41 11.99 CXCL8 ICAM1 IFNG IL17A IL1B TNF
42
Show member pathways
11.98 IFNG IL1B IL4
43 11.98 IL1B IL4 IL5 TNF
44 11.97 CXCL8 ICAM1 IL1B TNF
45 11.95 CXCL8 IFNG IL1B
46 11.93 CXCL8 ICAM1 IFNG IL4 IL5 SELE
47
Show member pathways
11.9 CXCL8 IFNG IL4 IL5 TNF
48
Show member pathways
11.89 CXCL8 ICAM1 IL17A
49 11.87 CXCL8 IL10 IL1B TNF
50 11.85 CXCL8 IFNG IL1B

GO Terms for Allergic Contact Dermatitis

Cellular components related to Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 CCL17 CXCL8 IFNG IL10 IL17A IL1B
2 external side of plasma membrane GO:0009897 9.46 CXCR3 ICAM1 IL17A TNF
3 extracellular space GO:0005615 9.44 CCL17 CXCL8 ICAM1 IFNG IL10 IL17A

Biological processes related to Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.97 CCL17 ICAM1 IL1B TNF
2 leukocyte migration GO:0050900 9.93 ICAM1 IL1B SELE TNF
3 response to lipopolysaccharide GO:0032496 9.91 ICAM1 IL10 IL1B SELE
4 inflammatory response GO:0006954 9.91 CCL17 CXCL8 CXCR3 IL10 IL17A IL1B
5 calcium-mediated signaling GO:0019722 9.86 CXCL8 CXCR3 SELE
6 neutrophil chemotaxis GO:0030593 9.85 CCL17 CXCL8 IL1B
7 chemokine-mediated signaling pathway GO:0070098 9.85 CCL17 CXCL8 CXCR3
8 immune response GO:0006955 9.85 CCL17 CXCL8 CXCR3 IFNG IL10 IL17A
9 regulation of insulin secretion GO:0050796 9.83 IFNG IL1B TNF
10 response to glucocorticoid GO:0051384 9.83 IL10 IL1B TNF
11 positive regulation of DNA-binding transcription factor activity GO:0051091 9.83 IL10 IL1B IL5 TNF
12 cellular response to lipopolysaccharide GO:0071222 9.83 CXCL8 ICAM1 IL10 IL1B TNF
13 positive regulation of interleukin-6 production GO:0032755 9.82 IL1B IL33 TNF
14 cellular response to interleukin-1 GO:0071347 9.8 CCL17 CXCL8 ICAM1 IL17A
15 extrinsic apoptotic signaling pathway GO:0097191 9.77 IFNG IL33 TNF
16 negative regulation of endothelial cell apoptotic process GO:2000352 9.72 ICAM1 IL10 IL4
17 negative regulation of lipid catabolic process GO:0050995 9.71 IL1B TNF
18 positive regulation of glial cell proliferation GO:0060252 9.71 IL1B TNF
19 positive regulation of macrophage activation GO:0043032 9.71 IL10 IL33
20 positive regulation of nitric oxide biosynthetic process GO:0045429 9.71 ICAM1 IFNG IL1B TNF
21 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.7 IL1B TNF
22 negative regulation of growth of symbiont in host GO:0044130 9.7 IL10 TNF
23 positive regulation of immunoglobulin secretion GO:0051024 9.69 IL33 IL5
24 positive regulation of podosome assembly GO:0071803 9.69 IL5 TNF
25 response to molecule of bacterial origin GO:0002237 9.69 CXCL8 IL10
26 positive regulation of osteoclast differentiation GO:0045672 9.69 IFNG IL17A TNF
27 positive regulation of chemokine secretion GO:0090197 9.68 IL33 TNF
28 positive regulation of interleukin-13 production GO:0032736 9.68 IL33 IL4
29 endothelial cell apoptotic process GO:0072577 9.67 IL10 TNF
30 positive regulation of chemokine biosynthetic process GO:0045080 9.66 IL1B TNF
31 positive regulation of MHC class II biosynthetic process GO:0045348 9.65 IL10 IL4
32 regulation of establishment of endothelial barrier GO:1903140 9.65 IL1B TNF
33 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.65 IFNG IL1B TNF
34 negative regulation of cytokine secretion involved in immune response GO:0002740 9.64 IL10 TNF
35 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.63 ICAM1 TNF
36 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.63 IL10 IL1B TNF
37 positive regulation of fever generation GO:0031622 9.62 IL1B TNF
38 positive regulation of interleukin-23 production GO:0032747 9.61 IFNG IL17A
39 cytokine-mediated signaling pathway GO:0019221 9.61 CXCL8 ICAM1 IL10 IL17A IL1B IL31
40 chronic inflammatory response to antigenic stimulus GO:0002439 9.59 IL1B TNF
41 regulation of isotype switching GO:0045191 9.58 IL10 IL4
42 sequestering of triglyceride GO:0030730 9.58 IL1B TNF
43 type 2 immune response GO:0042092 9.57 IL10 IL4
44 receptor biosynthetic process GO:0032800 9.56 IL10 TNF
45 positive regulation of vitamin D biosynthetic process GO:0060557 9.54 IFNG TNF
46 positive regulation of neuroinflammatory response GO:0150078 9.54 IL1B IL33 TNF
47 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.5 IFNG IL1B TNF
48 regulation of signaling receptor activity GO:0010469 9.36 CCL17 CXCL8 IFNG IL10 IL17A IL1B
49 positive regulation of transcription by RNA polymerase II GO:0045944 10.18 IL10 IL17A IL1B IL33 IL4 TNF
50 positive regulation of transcription, DNA-templated GO:0045893 10.09 IL10 IL1B IL4 IL5 TNF

Molecular functions related to Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.8 CCL17 CXCL8 FLG ICAM1 IFNG IL10
2 cytokine activity GO:0005125 9.36 CCL17 CXCL8 IFNG IL10 IL17A IL1B

Sources for Allergic Contact Dermatitis

3 CDC
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