MCID: ALL002
MIFTS: 23

Allergic Cutaneous Vasculitis

Categories: Cardiovascular diseases, Immune diseases

Aliases & Classifications for Allergic Cutaneous Vasculitis

MalaCards integrated aliases for Allergic Cutaneous Vasculitis:

Name: Allergic Cutaneous Vasculitis 12 15
Vasculitis, Leukocytoclastic, Cutaneous 71
Autoimmune Hypersensitivity Angiitis 12
Allergic Cutaneous Angiitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11450
UMLS 71 C0151436

Summaries for Allergic Cutaneous Vasculitis

Disease Ontology : 12 A hypersensitivity vasculitis that results in inflammation of small blood vessels, characterized clinically by palpable purpura, which is a slightly elevated purpuric rash over one or more areas of the skin.

MalaCards based summary : Allergic Cutaneous Vasculitis, also known as vasculitis, leukocytoclastic, cutaneous, is related to vasculitis and erythema nodosum. An important gene associated with Allergic Cutaneous Vasculitis is SPDEF (SAM Pointed Domain Containing ETS Transcription Factor), and among its related pathways/superpathways is C-MYB transcription factor network. The drugs Levoleucovorin and Dapsone have been mentioned in the context of this disorder.

Related Diseases for Allergic Cutaneous Vasculitis

Diseases related to Allergic Cutaneous Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 vasculitis 30.5 PRTN3 MPO
2 erythema nodosum 10.0
3 allergic disease 10.0
4 purpura 10.0
5 exanthem 9.9 PRTN3 EGFR
6 integumentary system disease 9.9 PRTN3 EGFR
7 purulent acute otitis media 9.8 PRTN3 MPO
8 multiple cranial nerve palsy 9.8 PRTN3 MPO
9 acute frontal sinusitis 9.8 PRTN3 MPO
10 anca-associated vasculitis 9.8 PRTN3 MPO
11 glossopharyngeal nerve disease 9.8 PRTN3 MPO
12 pulmonary hemosiderosis 9.8 PRTN3 MPO
13 mononeuritis of upper limb and mononeuritis multiplex 9.8 PRTN3 MPO
14 mononeuritis multiplex 9.8 PRTN3 MPO
15 anti-basement membrane glomerulonephritis 9.8 PRTN3 MPO
16 glomerulonephritis 9.8 PRTN3 MPO
17 subacute bacterial endocarditis 9.8 PRTN3 MPO
18 mastoiditis 9.8 PRTN3 MPO
19 aortitis 9.8 PRTN3 MPO
20 chondromalacia 9.8 PRTN3 MPO
21 maxillary sinusitis 9.8 PRTN3 MPO
22 scleral disease 9.8 PRTN3 MPO
23 orbital granuloma 9.8 PRTN3 MPO
24 cryptogenic organizing pneumonia 9.8 PRTN3 MPO
25 autoimmune vasculitis 9.8 PRTN3 MPO
26 mononeuropathy 9.8 PRTN3 MPO
27 central nervous system vasculitis 9.8 PRTN3 MPO
28 acute proliferative glomerulonephritis 9.8 PRTN3 MPO
29 autoimmune disease of urogenital tract 9.8 PRTN3 MPO
30 interstitial lung disease 9.8 PRTN3 EGFR
31 rapidly progressive glomerulonephritis 9.8 PRTN3 MPO
32 scleritis 9.8 PRTN3 MPO
33 hypersensitivity vasculitis 9.8 PRTN3 MPO
34 henoch-schoenlein purpura 9.8 PRTN3 MPO
35 hypersensitivity reaction type iii disease 9.8 PRTN3 MPO
36 goodpasture syndrome 9.8 PRTN3 MPO
37 pericardium disease 9.8 PRTN3 MPO
38 autoimmune disease of blood 9.8 PRTN3 MPO
39 middle ear disease 9.8 PRTN3 MPO
40 churg-strauss syndrome 9.8 PRTN3 MPO
41 autoimmune disease of cardiovascular system 9.8 PRTN3 MPO
42 polyarteritis nodosa 9.8 PRTN3 MPO
43 paranasal sinus disease 9.8 PRTN3 MPO
44 crescentic glomerulonephritis 9.8 PRTN3 MPO
45 temporal arteritis 9.8 PRTN3 MPO
46 alpha-1-antitrypsin deficiency 9.7 PRTN3 MPO
47 reactive arthritis 9.7 PRTN3 MPO
48 gastroesophageal reflux 9.7 MPO EGFR
49 sclerosing cholangitis 9.7 PRTN3 MPO
50 cholangitis 9.7 PRTN3 MPO

Graphical network of the top 20 diseases related to Allergic Cutaneous Vasculitis:



Diseases related to Allergic Cutaneous Vasculitis

Symptoms & Phenotypes for Allergic Cutaneous Vasculitis

Drugs & Therapeutics for Allergic Cutaneous Vasculitis

Drugs for Allergic Cutaneous Vasculitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Levoleucovorin Approved, Investigational Phase 4 68538-85-2 149436
2
Dapsone Approved, Investigational Phase 4 80-08-0 2955
3
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
4 Vitamin B Complex Phase 4
5 Anti-Infective Agents Phase 4
6 Folic Acid Antagonists Phase 4
7 Antiparasitic Agents Phase 4
8 Antiprotozoal Agents Phase 4
9 Folate Phase 4
10 Anti-Bacterial Agents Phase 4
11 Vitamin B9 Phase 4
12 Antimalarials Phase 4
13
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
14 Prednisolone acetate Approved, Vet_approved Phase 2 52-21-1
15
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
16
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
17
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
18
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
19 Anti-Inflammatory Agents Phase 2
20 Protective Agents Phase 2
21 Hormones Phase 2
22 Hormone Antagonists Phase 2
23 Neuroprotective Agents Phase 2
24 Methylprednisolone Acetate Phase 2
25 glucocorticoids Phase 2
26 Antineoplastic Agents, Hormonal Phase 2
27 Antiemetics Phase 2
28 Gastrointestinal Agents Phase 2
29
Prednisone Approved, Vet_approved 53-03-2 5865
30
Lenograstim Approved, Investigational 135968-09-1
31
Clotrimazole Approved, Vet_approved 23593-75-1 2812
32
Cyclophosphamide Approved, Investigational 50-18-0, 6055-19-2 2907
33
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
34 Immunosuppressive Agents
35 Immunologic Factors
36 Antilymphocyte Serum
37 Alkylating Agents
38 Cyclosporins
39 Antirheumatic Agents
40 Antifungal Agents
41 Dermatologic Agents
42 Calcineurin Inhibitors

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase IV, Randomised, Multicentre, Double-blind, Study to Evaluate the Clinical Utility of Prospective Genetic Screening (HLA-B*1301) for Susceptibility to Dapsone Hypersensitivity Syndrome Unknown status NCT02550080 Phase 4 Dapsone
2 Phase II Study of Prednisolone/Methylprednisolone Absorption in Children With Juvenile Dermatomyositis Completed NCT00004357 Phase 2 Methylprednisolone;Prednisolone
3 Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases Unknown status NCT00006055 anti-thymocyte globulin;cyclophosphamide;cyclosporine;filgrastim;methylprednisolone;prednisone

Search NIH Clinical Center for Allergic Cutaneous Vasculitis

Genetic Tests for Allergic Cutaneous Vasculitis

Anatomical Context for Allergic Cutaneous Vasculitis

Publications for Allergic Cutaneous Vasculitis

Articles related to Allergic Cutaneous Vasculitis:

(show all 14)
# Title Authors PMID Year
1
Possible pathogenetic mechanisms in allergic cutaneous vasculitis. 61
3292447 1988
2
Delayed hypersensitivity and differences of histologic pattern in allergic cutaneous vasculitis. 61
3364802 1988
3
[Ulcerative lesions of the legs as a manifestation of allergic cutaneous vasculitis]. 61
3381389 1988
4
[Experience using hemosorption therapy in allergic cutaneous vasculitis]. 61
6117996 1981
5
[Histamine content of blood and the use of antihistaminic drugs in allergic cutaneous vasculitis]. 61
33509 1978
6
[Allergic cutaneous vasculitis]. 61
724469 1978
7
[Symptomatic or secondary allergic vasculitis. Pathogenesis of cutaneous vasculitis]. 61
1240560 1975
8
[Allergic cutaneous vasculitis (purpura Schönlein-Henoch) (author's transl)]. 61
804593 1975
9
[Pathogenetic considerations on an unusual case of allergic cutaneous vasculitis]. 61
5558154 1971
10
Erythema nodosum: a form of allergic cutaneous vasculitis. 61
5664515 1968
11
Allergic cutaneous vasculitis report of a case. 61
13835070 1959
12
Allergic cutaneous vasculitis; report of a unique case. 61
13371912 1956
13
A case of allergic cutaneous vasculitis (arteriolitis allergica). 61
13032316 1953
14
Allergic cutaneous vasculitis. 61
14932676 1952

Variations for Allergic Cutaneous Vasculitis

Expression for Allergic Cutaneous Vasculitis

Search GEO for disease gene expression data for Allergic Cutaneous Vasculitis.

Pathways for Allergic Cutaneous Vasculitis

Pathways related to Allergic Cutaneous Vasculitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.52 PRTN3 MPO

GO Terms for Allergic Cutaneous Vasculitis

Cellular components related to Allergic Cutaneous Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 azurophil granule lumen GO:0035578 8.62 PRTN3 MPO

Biological processes related to Allergic Cutaneous Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to oxidative stress GO:0006979 8.62 MPO EGFR

Sources for Allergic Cutaneous Vasculitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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