MCID: ALL002
MIFTS: 25

Allergic Cutaneous Vasculitis

Categories: Cardiovascular diseases, Immune diseases, Skin diseases

Aliases & Classifications for Allergic Cutaneous Vasculitis

MalaCards integrated aliases for Allergic Cutaneous Vasculitis:

Name: Allergic Cutaneous Vasculitis 12 15
Vasculitis, Leukocytoclastic, Cutaneous 71
Autoimmune Hypersensitivity Angiitis 12
Allergic Cutaneous Angiitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11450
UMLS 71 C0151436

Summaries for Allergic Cutaneous Vasculitis

Disease Ontology : 12 A hypersensitivity vasculitis that results in inflammation of small blood vessels, characterized clinically by palpable purpura, which is a slightly elevated purpuric rash over one or more areas of the skin.

MalaCards based summary : Allergic Cutaneous Vasculitis, also known as vasculitis, leukocytoclastic, cutaneous, is related to vasculitis and purulent acute otitis media. An important gene associated with Allergic Cutaneous Vasculitis is ZBP1 (Z-DNA Binding Protein 1), and among its related pathways/superpathways is C-MYB transcription factor network. The drugs leucovorin and Dapsone have been mentioned in the context of this disorder. Affiliated tissues include skin, and related phenotype is immune system.

Related Diseases for Allergic Cutaneous Vasculitis

Diseases related to Allergic Cutaneous Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Related Disease Score Top Affiliating Genes
1 vasculitis 29.9 PRTN3 MPO CD40LG
2 purulent acute otitis media 10.0 PRTN3 MPO
3 orbital granuloma 10.0 PRTN3 MPO
4 anca-associated vasculitis 10.0 PRTN3 MPO
5 multiple cranial nerve palsy 10.0 PRTN3 MPO
6 pulmonary hemosiderosis 10.0 PRTN3 MPO
7 anti-basement membrane glomerulonephritis 10.0 PRTN3 MPO
8 chondromalacia 10.0 PRTN3 MPO
9 autoimmune vasculitis 10.0 PRTN3 MPO
10 allergic hypersensitivity disease 9.9
11 purpura 9.9
12 zika virus congenital syndrome 9.9 ZBP1 CD40LG
13 polyarteritis nodosa 9.9 PRTN3 MPO
14 crescentic glomerulonephritis 9.9 PRTN3 MPO
15 chronic orbital inflammation 9.9 PRTN3 CD40LG
16 cranial nerve palsy 9.9 PRTN3 CD40LG
17 splenic infarction 9.8 PRTN3 CD40LG
18 tenosynovitis 9.8 PRTN3 CD40LG
19 pyuria 9.8 PRTN3 CD40LG
20 central retinal artery occlusion 9.8 PRTN3 CD40LG
21 lung abscess 9.8 PRTN3 CD40LG
22 cryptogenic organizing pneumonia 9.8 PRTN3 CD40LG
23 tendinitis 9.8 PRTN3 CD40LG
24 facial nerve disease 9.8 PRTN3 CD40LG
25 facial paralysis 9.8 PRTN3 CD40LG
26 impetigo 9.8 PRTN3 CD40LG
27 alpha-1-antitrypsin deficiency 9.8 PRTN3 MPO
28 plasma protein metabolism disease 9.8 PRTN3 CD40LG
29 autoimmune disease of cardiovascular system 9.8 PRTN3 CD40LG
30 autoimmune disease of exocrine system 9.8 PRTN3 CD40LG
31 reactive arthritis 9.8 PRTN3 MPO
32 good syndrome 9.8 EGFR CD40LG
33 endocardium disease 9.8 PRTN3 CD40LG
34 syphilis 9.7 PRTN3 CD40LG
35 hypersensitivity reaction type iv disease 9.7 PRTN3 CD40LG
36 nose disease 9.7 PRTN3 CD40LG
37 limited scleroderma 9.7 PRTN3 CD40LG
38 thymus gland disease 9.7 EGFR CD40LG
39 thymus cancer 9.7 EGFR CD40LG
40 bronchopneumonia 9.7 MPO CD40LG
41 immune-complex glomerulonephritis 9.7 MPO CD40LG
42 collagenous colitis 9.7 MPO CD40LG
43 salivary gland disease 9.7 EGFR CD40LG
44 brucellosis 9.6 MPO CD40LG
45 lymphoid interstitial pneumonia 9.6 PRTN3 CD40LG
46 pelvic inflammatory disease 9.6 MPO CD40LG
47 hair disease 9.5 EGFR CD40LG
48 potocki-shaffer syndrome 9.5 SPDEF CD40LG
49 integumentary system disease 9.5 PRTN3 EGFR CD40LG
50 interstitial lung disease 9.4 PRTN3 EGFR CD40LG

Graphical network of the top 20 diseases related to Allergic Cutaneous Vasculitis:



Diseases related to Allergic Cutaneous Vasculitis

Symptoms & Phenotypes for Allergic Cutaneous Vasculitis

MGI Mouse Phenotypes related to Allergic Cutaneous Vasculitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.1 CD40LG EGFR MPO PRTN3 SPDEF ZBP1

Drugs & Therapeutics for Allergic Cutaneous Vasculitis

Drugs for Allergic Cutaneous Vasculitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
leucovorin Approved Phase 4 58-05-9 6006 143
2
Dapsone Approved, Investigational Phase 4 80-08-0 2955
3
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
4 Anti-Infective Agents Phase 4
5 Vitamin B Complex Phase 4
6 Folic Acid Antagonists Phase 4
7 Antiprotozoal Agents Phase 4
8 Antiparasitic Agents Phase 4
9 Anti-Bacterial Agents Phase 4
10 Folate Phase 4
11 Vitamin B9 Phase 4
12 Antimalarials Phase 4
13
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
14
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
15
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
16 Prednisolone acetate Approved, Vet_approved Phase 2 52-21-1
17
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
18
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
19 Gastrointestinal Agents Phase 2
20 Hormones Phase 2
21 Methylprednisolone Acetate Phase 2
22 Antineoplastic Agents, Hormonal Phase 2
23 Antiemetics Phase 2
24 Hormone Antagonists Phase 2
25 glucocorticoids Phase 2
26 Neuroprotective Agents Phase 2
27 Protective Agents Phase 2
28 Anti-Inflammatory Agents Phase 2
29
Prednisone Approved, Vet_approved 53-03-2 5865
30
Lenograstim Approved, Investigational 135968-09-1
31
Clotrimazole Approved, Vet_approved 23593-75-1 2812
32
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
33
Cyclophosphamide Approved, Investigational 50-18-0, 6055-19-2 2907
34 Immunologic Factors
35 Immunosuppressive Agents
36 Dermatologic Agents
37 Alkylating Agents
38 Antifungal Agents
39 Cyclosporins
40 Calcineurin Inhibitors
41 Antirheumatic Agents
42 Antilymphocyte Serum

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase IV, Randomised, Multicentre, Double-blind, Study to Evaluate the Clinical Utility of Prospective Genetic Screening (HLA-B*1301) for Susceptibility to Dapsone Hypersensitivity Syndrome Unknown status NCT02550080 Phase 4 Dapsone
2 Phase II Study of Prednisolone/Methylprednisolone Absorption in Children With Juvenile Dermatomyositis Completed NCT00004357 Phase 2 Methylprednisolone;Prednisolone
3 Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases Unknown status NCT00006055 anti-thymocyte globulin;cyclophosphamide;cyclosporine;filgrastim;methylprednisolone;prednisone

Search NIH Clinical Center for Allergic Cutaneous Vasculitis

Genetic Tests for Allergic Cutaneous Vasculitis

Anatomical Context for Allergic Cutaneous Vasculitis

MalaCards organs/tissues related to Allergic Cutaneous Vasculitis:

40
Skin

Publications for Allergic Cutaneous Vasculitis

Articles related to Allergic Cutaneous Vasculitis:

(show all 14)
# Title Authors PMID Year
1
Possible pathogenetic mechanisms in allergic cutaneous vasculitis. 61
3292447 1988
2
Delayed hypersensitivity and differences of histologic pattern in allergic cutaneous vasculitis. 61
3364802 1988
3
[Ulcerative lesions of the legs as a manifestation of allergic cutaneous vasculitis]. 61
3381389 1988
4
[Experience using hemosorption therapy in allergic cutaneous vasculitis]. 61
6117996 1981
5
[Histamine content of blood and the use of antihistaminic drugs in allergic cutaneous vasculitis]. 61
33509 1978
6
[Allergic cutaneous vasculitis]. 61
724469 1978
7
[Allergic cutaneous vasculitis (purpura Schönlein-Henoch) (author's transl)]. 61
804593 1975
8
[Symptomatic or secondary allergic vasculitis. Pathogenesis of cutaneous vasculitis]. 61
1240560 1975
9
[Pathogenetic considerations on an unusual case of allergic cutaneous vasculitis]. 61
5558154 1971
10
Erythema nodosum: a form of allergic cutaneous vasculitis. 61
5664515 1968
11
Allergic cutaneous vasculitis report of a case. 61
13835070 1959
12
Allergic cutaneous vasculitis; report of a unique case. 61
13371912 1956
13
A case of allergic cutaneous vasculitis (arteriolitis allergica). 61
13032316 1953
14
Allergic cutaneous vasculitis. 61
14932676 1952

Variations for Allergic Cutaneous Vasculitis

Expression for Allergic Cutaneous Vasculitis

Search GEO for disease gene expression data for Allergic Cutaneous Vasculitis.

Pathways for Allergic Cutaneous Vasculitis

Pathways related to Allergic Cutaneous Vasculitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.52 PRTN3 MPO

GO Terms for Allergic Cutaneous Vasculitis

Sources for Allergic Cutaneous Vasculitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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