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MCID: ALL029
MIFTS: 59

Allergic Disease

Categories: Immune diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Allergic Disease

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MalaCards integrated aliases for Allergic Disease:

Name: Allergic Disease 12 15
Hypersensitivity 12 74 44 15
Allergic Hypersensitivity Disease 12

Classifications:

MalaCards categories:
Anatomical: Immune diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:1205
MeSH 44 D006967
NCIt 50 C3114
SNOMED-CT 67 257550005
ICD10 32 T78.40
UMLS 71 C0020517
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Summaries for Allergic Disease

About this section
Disease Ontology : 12 An immune system disease that is an exaggerated immune response to allergens, such as insect venom, dust mites, pollen, pet dander, drugs or some foods.

MalaCards based summary : Allergic Disease, also known as hypersensitivity, is related to nut allergy and hypersensitivity reaction type iv disease. An important gene associated with Allergic Disease is IL5 (Interleukin 5), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Lidocaine and Oxytocin have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and prostate, and related phenotypes are hematopoietic system and immune system

Wikipedia : 74 Hypersensitivity (also called hypersensitivity reaction or intolerance) refers to undesirable reactions... more...

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Related Diseases for Allergic Disease

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Diseases related to Allergic Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1857)
# Related Disease Score Top Affiliating Genes
1 nut allergy 32.8 IL5 IL4 IL13
2 hypersensitivity reaction type iv disease 32.4 TNF IL6 IL4 IL2 IL1B IFNG
3 respiratory allergy 32.2 RNASE3 IL5 IL4 IL3 IL13
4 erythema multiforme 32.2 TNF IL6 IL5 IL4 IL2 IFNG
5 metal allergy 32.1 TLR4 IL4 IL2
6 latex allergy 32.1 TNF RNASE3 IL5 IL4 IL13 IFNG
7 bagassosis 32.1 TNF IL6 IL5 IL1B
8 sarcoidosis 1 32.0 TNF IL9 IL2 IL1B IL13 IFNG
9 pulmonary sarcoidosis 32.0 TNF IL2 IFNG
10 bullous pemphigoid 32.0 TNF RNASE3 IL5 IL4 IL13 CCL11
11 cardiac sarcoidosis 32.0 TNF IL5 IL1B IFNG
12 bronchiolitis obliterans 31.9 TNF TLR4 IL6 IL13 IFNG FOXP3
13 cryoglobulinemia 31.9 TSLP TNF IL6 IL1B IFNG
14 toxicodendron dermatitis 31.9 TNF IL2
15 allergic asthma 31.9 TSLP TLR4 RNASE3 IL9 IL5 IL4
16 ige responsiveness, atopic 31.9 RNASE3 IL5 IL4 IL13 IFNG
17 churg-strauss syndrome 31.9 TNF RNASE3 IL5 IL3 IL2 IL1B
18 allergic rhinitis 31.7 RNASE3 IL9 IL5 IL4 IL13 IFNG
19 autoimmune disease of central nervous system 31.6 TNF TLR4 IL6 IL5 IL4 IL2
20 stevens-johnson syndrome/toxic epidermal necrolysis 31.6 IL5 IL2 IL13 IFNG CCR3 CCL22
21 pollen allergy 31.5 RNASE3 IL5 IL3 IL13 FOXP3 EPX
22 food allergy 31.5 TNF TLR4 RNASE3 IL5 IL4 IL13
23 rhinitis 31.5 TSLP TNF RNASE3 IL9 IL6 IL5
24 dermatitis 31.5 TSLP TNF RNASE3 IL6 IL5 IL4
25 dermatitis, atopic 31.4 TSLP TNF TLR4 RNASE3 IL9 IL6
26 urticaria 31.4 TNF RNASE3 IL6 IL5 IL4 IL13
27 gingival recession 31.4 TNF IL6 IL1B
28 interstitial lung disease 31.4 TNF IL6 IL5 IL4 IL33 IL1B
29 penicillin allergy 31.3 IL4 IL13 IFNG
30 purpura 31.3 TNF IL6 IL4 IL1B IFNG
31 myocarditis 31.3 TNF TLR4 IL6 IL4 IL2 IL1B
32 cytokine deficiency 31.2 IL9 IL5 IL13
33 alopecia 31.1 TNF IL4 IL2 IL1B IFNG
34 pulmonary fibrosis, idiopathic 31.1 TSLP TNF TLR4 IL9 IL6 IL5
35 peripheral nervous system disease 31.1 TNF TLR4 IL6 IL4 IL2 IL1B
36 diarrhea 31.1 TNF TLR4 IL6 IL5 IL2 IL1B
37 schistosomiasis 31.1 TNF RNASE3 IL9 IL5 IL4 IL33
38 leprosy 3 31.1 TNF TLR4 IL6 IL5 IL4 IL2
39 pulmonary tuberculosis 31.0 TNF IL6 IL4 IL2 IFNG
40 irritant dermatitis 31.0 TSLP TNF IL6 IL4 IL1B
41 stomatitis 31.0 TNF IL6 IL4 IL2 IL1B IFNG
42 cholera 31.0 TNF IL6 IL5 IL4 IL1B
43 idiopathic interstitial pneumonia 31.0 IL4 IL13 IFNG
44 milk allergy 31.0 TNF RNASE3 IL9 IL5 IL4 IL13
45 pneumonia 31.0 TNF TLR4 IL6 IL5 IL4 IL1B
46 brucellosis 31.0 TNF TLR4 IL6 IL4 IL2 IL13
47 fibromyalgia 31.0 TNF IL6 IL1B
48 gout 31.0 TNF TLR4 IL6 IL1B
49 vernal keratoconjunctivitis 30.9 RNASE3 IL5 IL4 IL13 CCL11
50 eosinophilic pneumonia 30.9 RNASE3 IL5 IL4 IL33 IL3 IL13

Graphical network of the top 20 diseases related to Allergic Disease:



Diseases related to Allergic Disease
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Symptoms & Phenotypes for Allergic Disease

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MGI Mouse Phenotypes related to Allergic Disease:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.41 CCL11 CCR3 EPX FOXP3 GATA3 IFNG
2 immune system MP:0005387 10.39 CCL11 CCL22 CCR3 EPX FOXP3 GATA3
3 homeostasis/metabolism MP:0005376 10.36 CCR3 EPX FOXP3 GATA3 IFNG IL13
4 digestive/alimentary MP:0005381 10.32 FOXP3 GATA3 IFNG IL13 IL2 IL33
5 growth/size/body region MP:0005378 10.31 FOXP3 GATA3 IFNG IL13 IL1B IL2
6 integument MP:0010771 10.14 FOXP3 GATA3 IFNG IL13 IL1B IL33
7 liver/biliary system MP:0005370 9.97 FOXP3 IFNG IL2 IL4 IL5 IL6
8 reproductive system MP:0005389 9.9 FOXP3 GATA3 IFNG IL13 IL2 IL33
9 neoplasm MP:0002006 9.87 IFNG IL1B IL2 IL5 IL6 TLR4
10 no phenotypic analysis MP:0003012 9.86 FOXP3 GATA3 IFNG IL13 IL2 IL33
11 respiratory system MP:0005388 9.77 CCL11 CCR3 FOXP3 IFNG IL13 IL2
12 skeleton MP:0005390 9.32 EPX GATA3 IFNG IL13 IL1B IL33
Sources

Drugs & Therapeutics for Allergic Disease

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Drugs for Allergic Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 708)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
2
Oxytocin Approved, Vet_approved Phase 4 50-56-6 439302 53477758
3
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
4
Dapsone Approved, Investigational Phase 4 80-08-0 2955
5
Linagliptin Approved Phase 4 668270-12-0 10096344
6
Reboxetine Approved, Experimental Phase 4 71620-89-8, 98769-81-4 123628 65856
7
Fludrocortisone Approved, Investigational Phase 4 127-31-1 31378
8
Fluticasone Approved, Experimental Phase 4 90566-53-3 62924
9
Budesonide Approved Phase 4 51333-22-3 63006 5281004
10 sodium fluoride Approved Phase 4 7681-49-4
11
Hydrogen peroxide Approved, Vet_approved Phase 4 7722-84-1 784
12
Montelukast Approved Phase 4 158966-92-8 5281040
13
Calcium carbonate Approved, Investigational Phase 4 471-34-1
14
Histamine Approved, Investigational Phase 4 51-45-6, 75614-87-8 774
15
Glycerol Approved, Investigational Phase 4 56-81-5 753
16
Metronidazole Approved Phase 4 443-48-1 4173
17
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
18
Capsaicin Approved Phase 4 404-86-4 1548943
19
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
20
Ciclesonide Approved, Investigational Phase 4 126544-47-6, 141845-82-1 444033
21
Levocetirizine Approved Phase 4 130018-77-8 1549000
22
Loratadine Approved, Investigational Phase 4 79794-75-5 3957
23
Epinastine Approved, Investigational Phase 4 80012-43-7 3241
24
carbamide peroxide Approved Phase 4 124-43-6
25
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
26
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
27
Dimenhydrinate Approved Phase 4 523-87-5 441281
28
Rosiglitazone Approved, Investigational Phase 4 122320-73-4 77999
29
Etodolac Approved, Investigational, Vet_approved Phase 4 41340-25-4 3308
30
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
31
Vildagliptin Approved, Investigational Phase 4 274901-16-5 6918537
32
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
33
Irbesartan Approved, Investigational Phase 4 138402-11-6 3749
34
Zoledronic Acid Approved Phase 4 118072-93-8 68740
35
Adapalene Approved Phase 4 106685-40-9 60164
36
Benzoyl peroxide Approved Phase 4 94-36-0 7187
37
Liraglutide Approved Phase 4 204656-20-2 44147092
38
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
39
Clarithromycin Approved Phase 4 81103-11-9 84029
40
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 161973-10-0, 119141-88-7 9568614 4594
41
Ofloxacin Approved Phase 4 82419-36-1 4583
42
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
43
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
44
Ipratropium Approved, Experimental Phase 4 22254-24-6, 60205-81-4 43232 657309
45
Omalizumab Approved, Investigational Phase 4 242138-07-4
46
Sodium citrate Approved, Investigational Phase 4 68-04-2
47
Cetrorelix Approved, Investigational Phase 4 120287-85-6 16129715 25074887
48
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
49
Polyestradiol phosphate Approved Phase 4 28014-46-2
50
Citalopram Approved Phase 4 59729-33-8 2771

Interventional clinical trials:

(show top 50) (show all 1649)
# Name Status NCT ID Phase Drugs
1 Cross-reactivity and Tolerability of Ertapenem in Patients With IgE-mediated Allergy to Beta-lactams Unknown status NCT01159379 Phase 4 ertapenem
2 Clinical Efficacy of Giomer Versus Sodium Fluoride Varnish for Management of Hypersensitivity: Randomized Control Trail Unknown status NCT03818945 Phase 4 shofu PRG barrier coat;Sodium fluoride varnish
3 Bacteria and Cytokines as Factors Modulating Visceral Afferent Processing in Irritable Bowel Syndrome: Manipulation of Intestinal Bacteria and Mucosal Cytokines by Probiotic Therapy and the Effect on Visceral Hypersensitivity Unknown status NCT00418340 Phase 4 probiotic (bacterial/dietary supplement)
4 A Phase IV, Randomised, Multicentre, Double-blind, Study to Evaluate the Clinical Utility of Prospective Genetic Screening (HLA-B*1301) for Susceptibility to Dapsone Hypersensitivity Syndrome Unknown status NCT02550080 Phase 4 Dapsone
5 Effects of Pioglitazone on Body Composition,Insulin Sensitivity and Protein Metabolism in ESRD Non Diabetic Individuals Unknown status NCT01253928 Phase 4 Pioglitazone
6 A Double Blind Placebo Controlled Randomised Trial to Study the Effects of Birch Pollen Specific Immunotherapy (BP-SIT) on the Symptoms of the Oral Allergy Syndrome in Adult Patients Unknown status NCT01431859 Phase 4
7 Effect of Escitalopram vs. Reboxetine on Somatic and Visceral Sensitivity of Patients With Major Depressive Disorder: a Randomized, Double Blind Clinical Trial Unknown status NCT00209807 Phase 4 escitalopram;Reboxetine
8 The Effect of Intranasal Oxytocin on Pain Sensitivity and Threshold: A Randomized, Double Blinded, Crossover Volunteer Study Unknown status NCT02550093 Phase 4 Normal Saline;Oxytocin
9 A Randomized Double-blind Study to Evaluate the Effect of Linagliptin on Pancreatic Beta Cell Function and Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus on Metformin Monotherapy Unknown status NCT02097342 Phase 4 Linagliptin;Placebo;Voglibose
10 Fludrocortisone's Test in the Identification of Salt Sensitivity Unknown status NCT01453959 Phase 4 Fludrocortisone
11 Distribution and Expression of Non-neuronal Transient Receptor Potential (TRPV) Ion Channels in Sensitive Skin Syndrome. Unknown status NCT01871883 Phase 4
12 The Effects of Xolair (Omalizumab) on Airway Hyperresponsiveness Unknown status NCT00208234 Phase 4 Omalizumab;Placebo for Omalizumab;omalizumab
13 A Phase IV, Randomised, Multicentre, Double-blind, Study to Evaluate the Clinical Utility of Prospective Genetic Screening (HLA-B*5701) for Susceptibility to Abacavir Hypersensitivity Completed NCT00340080 Phase 4 Abacavir
14 Basophil Activation Test (BAT) Sensitivity in Child Food Allergy Completed NCT01966640 Phase 4
15 The Role of Nonspecific Immune Response of the Airway Mucosa in Children With Chronic Rhinosinusitis and Asthma Completed NCT03011632 Phase 4 Mometasone Nasal;placebo mometasone
16 Integrated Approaches to Food Allergen and Allergy Risk Management: iFAAM: The Impact of Proton-pump Inhibitors (Antacids) on Threshold Dose Distributions Completed NCT02552537 Phase 4 Omeprazole;Placebo
17 Phase 4 Study: Milk Oral Immunotherapy for Cow's Milk Allergy in School-aged Children Completed NCT01361347 Phase 4
18 Phase 4 Study to Assess the Safety of Nasal Influenza Immunisation in Egg Allergic Children - a Multicentre Observational Study Completed NCT02111512 Phase 4 Administration of Live attenuated influenza vaccine (LAIV)
19 Phase 4 Study of Effects of Montelukast Treatment on Allergic Inflammation in Children With and Without Food Allergy, Single Centered, Randomised, Double Blind, Placebo Controlled Parallel Group Cross-over Study Completed NCT01618929 Phase 4 Montelukast
20 A Double-blind, Double-dummy, Parallel-group, Placebo-controlled, Randomized Study to Assess the Duration of the Suppressive Effects of Desloratadine on the Cutaneous Allergen-induced Wheal and Flare (1) Response After Discontinuation Completed NCT00359138 Phase 4 desloratadine;levocetirizine;Desloratadine placebo tablet;Levocetirizine placebo capsule
21 An Exploratory Clinical Study to Evaluate the Efficacy of Two Currently Marketed Toothpastes Containing Different Concentrations of a Tubule Occlusion Agent Completed NCT01075256 Phase 4
22 Efficacy and Safety of Danggui-Sayuk-Ga-Osuyu-Saenggang-tang on Korean Patients With Cold Hypersensitivity in the Hands Completed NCT02645916 Phase 4 Danggui-Sayuk-Ga-Osuyu-Saenggang-tang;Placebo: corn starch
23 Clinical, Controlled, Double-blind Study on the Effect of Whitening Dentifrices on Tooth Color and Tooth Sensitivity Completed NCT02483013 Phase 4
24 Investigating the Efficacy of Artificial Tear Supplements and Cold Compresses for the Treatment of Seasonal Allergic Conjunctivitis Completed NCT01569191 Phase 4 Anti-allergic Medication
25 Evaluating Remineralizers and Desensitizers Agents in Dental Bleaching Treatment: in Vitro and in Vivo Study Completed NCT02316080 Phase 4
26 Effectiveness of Nano-hydroxyapetite Care Paste in Reducing Dentinhypersenstitivity: A Double Blind Randomized Control Trial Completed NCT02936830 Phase 4 5% Sodium Fluoride Varnish;15% Nanohydroxyapetite paste;Glycerol
27 Effect of Korean Red Ginseng on Women With Cold Hypersensitivity of Hands and Feet : a Randomized, Double-blind, Placebo-controlled Trial Completed NCT01664156 Phase 4 Korean red ginseng;Placebo
28 Short Term Clinical Study Investigating the Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity Completed NCT02773758 Phase 4
29 A Clinical Study Investigating the Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity Completed NCT02731833 Phase 4
30 Manipulation of Visceral Hypersensitivity With Probiotic Bacteria in Irritable Bowel Syndrome Completed NCT01139736 Phase 4
31 An 8-Week Clinical Study to Evaluate the Efficacy of Two Oral Hygiene Regimens in the Reduction of Dentin Hypersensitivity After Non-surgical Periodontal Treatment: Randomized Clinical Trial Completed NCT02461030 Phase 4 In-office and at home Colgate sensitive pro-relief - CSPR;In-office Villevie® prophy paste + Colgate Toothpaste
32 A Clinical Study Investigating the Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity Completed NCT02923895 Phase 4
33 Spherical Aberration and Contrast Sensitivity in Eyes Implanted With Aspheric and Spherical Intraocular Lenses: Clinical Comparative Study Completed NCT00576485 Phase 4
34 A Prospective,Open-label Study of Anastrozole in Post-menopausal Women With Hormone Sensitive Advanced Breast Cancer Completed NCT00544986 Phase 4 Anastrozole
35 Sensitivity of Electrocardiogram on Detection of Three Different Intravascular Applied Test Doses of Bupivacaine and Epinephrine: a Study in Children of Different Age Completed NCT01091766 Phase 4 intravenous injection of test solution;intravenous injection of test solution;intravenous injection of test solution
36 Evaluation Of Visual Outcomes and Contrast Sensitivity After Myopic Wavefront-Optimized Lasik Using the 200 KHZ WAVELIGHT® FS200 Femtosecond Laser and the WAVELIGHT® ALLEGRETTO WAVE® EYE-Q Laser Completed NCT01746589 Phase 4
37 Effect of Tadalafil on Insulin Secretion and Insulin Sensitivity in Obese Men. Completed NCT02595684 Phase 4 Tadalafil;Placebo
38 TBE (Tick-borne Encephalitis ) Vaccination in Allergic Patients Completed NCT02511535 Phase 4
39 Insulin Resistance and Intramyocellular Lipid Content in Glucose Intolerant Subjects Receiving Rosiglitazone Completed NCT00746174 Phase 4 Rosiglitazone;Placebo
40 Phase 4 Study of the Effect of Statin Treatment on Insulin Sensitivity During Myocardial Infarction Completed NCT01205347 Phase 4 Simvastatin 80mg;Simvastatin 10mg
41 Preemptive Use of Etodolac on Tooth Sensitivity Caused by In-office Bleaching: a Randomized, Triple-blind, Controlled Clinical Trial Completed NCT02881619 Phase 4 Etodolac;Placebo
42 Multicenter Study for Evaluation of Efficacy and Safety of Perennial Specific Immunotherapy With a Depot House Dust Mite Allergen Extract (D. Pteronyssinus 100%) in Patients With House Dust Mite Sensitivity Completed NCT00263549 Phase 4
43 A Double Blind Randomized Control Trial to Study the Effect of Long Term Vitamin D Supplementation on Peripheral Insulin Sensitivity in Apparently Healthy Middle Aged Centrally Obese Adults Completed NCT01052181 Phase 4 Cholecalciferol;placebo
44 Insulin Sensitivity and Beta Cell Function After Carbohydrate Loading in Hip Replacement Surgery: A Randomised Doubled-blinded Control Study Completed NCT01774084 Phase 4
45 The Effect of Corticotrophin-releasing Hormone (CRH) on Esophageal Sensitivity in Healthy Volunteers: A Randomized, Single-blind, Placebo-controlled Study Completed NCT02674256 Phase 4 CRH
46 Insulin Sensitivity After Metformin Suspension in Normal-Weight Women With Polycystic Ovary Syndrome Completed NCT00437333 Phase 4 Metformin cloridrate
47 Effects of Blood Pressure Reduction on High Sensitivity C-Reactive Protein (hsCRP) Completed NCT00154271 Phase 4 Valsartan, Valsartan HCT
48 Oral Contraceptives, Insulin Resistance and Cardiovascular Risk Profile in Pre-Menopausal Women Completed NCT01475513 Phase 4 Ortho Cyclen®
49 Does a Lipophilic Steroid Inhaled After an Early Allergic Reaction Affect the Late Reaction? Completed NCT00716963 Phase 4 Fluticasone propionate (Flovent Diskus) 250 mcg;budesonide 400 mcg
50 A Placebo Controlled, Double-Blind Investigation of the Therapeutic Utility of Xolair (Omalizumab) for Attenuating Aspirin Induced Bronchospasm in Patients With Aspirin Exacerbated Respiratory Disease (AERD) Undergoing Aspirin Desentization Completed NCT00555971 Phase 4 Omalizumab;placebo

Search NIH Clinical Center for Allergic Disease

Cochrane evidence based reviews: hypersensitivity

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Genetic Tests for Allergic Disease

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Anatomical Context for Allergic Disease

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MalaCards organs/tissues related to Allergic Disease:

40
Skin, T Cells, Prostate, Breast, Spinal Cord, Brain, Eye
Sources

Publications for Allergic Disease

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Articles related to Allergic Disease:

(show top 50) (show all 35580)
# Title Authors PMID Year
1
Ibrutinib-induced acute kidney injury via interstitial nephritis. 61
33567947 2021
2
Assessing the impact of pain-linked Nav1.7 variants: An example of two variants with no biophysical effect. 61
33487118 2021
3
Changes in peripheral HCN2 channels during persistent inflammation. 61
33423595 2021
4
A five-year retrospective study of treatment outcomes using the L-asparaginase-based regimen as a first-line chemotherapy protocol for patients diagnosed with extranodal NK/T-cell lymphoma, nasal-type, in Thailand. 61
33427594 2021
5
Extraction of total wheat (Triticum aestivum) protein fractions and cross-reactivity of wheat allergens with other cereals. 61
33486358 2021
6
Core epitope analysis of 16 kDa allergen from tartary buckwheat. 61
33412487 2021
7
Effect of heat, enzymatic hydrolysis and acid-alkali treatment on the allergenicity of silkworm pupa protein extract. 61
33131957 2021
8
The µ-δ opioid heteromer masks latent pain sensitization in neuropathic and inflammatory pain in male and female mice. 61
33516809 2021
9
Radiofrequency at 2.45 GHz increases toxicity, pro-inflammatory and pre-apoptotic activity caused by black carbon in the RAW 264.7 macrophage cell line. 61
33071139 2021
10
The Diagnosis and Treatment of Pulmonary Fibrosis. 61
33531115 2021
11
Dental metal hypersensitivity in patients with psoriasis vulgaris: A case-control study using an in vitro quantitative sensitivity test. 61
33392393 2021
12
Eukaryotic initiation factor 4 gamma 2 contributes to neuropathic pain through down-regulation of Kv1.2 and the mu opioid receptor in mouse primary sensory neurones. 61
33303185 2021
13
Safety of Off-Label Use of Ferumoxtyol as a Contrast Agent for MRI: A Systematic Review and Meta-Analysis of Adverse Events. 61
33098154 2021
14
Clinical Characteristics, Urinary Leukotriene E4 Levels, and Aspirin Desensitization Results in Patients With NSAID-Induced Blended Reactions. 61
33474858 2021
15
Mast cells in the paraventricular nucleus participate in visceral hypersensitivity induced by neonatal maternal separation. 61
33412227 2021
16
Dynamic cytokine profiles combined with enzyme-linked immunospot assay are useful for immunologically confirming the dapsone hypersensitivity syndrome. 61
32553674 2021
17
Severe Cutaneous Adverse Reactions to Anti-tuberculosis Drugs in Korean Patients. 61
33474859 2021
18
Arabidopsis MHP1, a homologue of yeast Mpo1, is involved in ABA signaling. 61
33568285 2021
19
The Impact of Product and Process Related Critical Quality Attributes on Immunogenicity and Adverse Immunological Effects of Biotherapeutics. 61
33316242 2021
20
CRISPR/Cas9-mediated generation and analysis of N terminus polymorphic models of β2AR in isogenic hPSC-derived cardiomyocytes. 61
33335946 2021
21
Overexpression of the wheat NAC transcription factor TaSNAC4-3A gene confers drought tolerance in transgenic Arabidopsis. 61
33454635 2021
22
Hyperacusis in tinnitus patients relates to enlarged subcortical and cortical responses to sound except at the tinnitus frequency. 61
33421659 2021
23
High Rate of Pain Sensitization in Musculoskeletal Shoulder Diseases: A Systematic Review and Meta-analysis. 61
33399396 2021
24
Antibacterial antibiotic-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a literature review. 61
33025080 2021
25
The dietary practices and beliefs of people living with inactive ulcerative colitis. 61
32956176 2021
26
Plasma cell mucositis related to qat chewing: a report of 2 cases and review of the literature. 61
33158807 2021
27
Editorial: A trio of articles on Covid-19, followed by articles on vaping, hypersensitivity pneumonitis, and several on obstructive airway and pulmonary diseases. 61
33394751 2021
28
An update on hypersensitivity pneumonitis: what a clinician wants to know. 61
33470673 2021
29
Deep sequencing of prostaglandin-endoperoxide synthase (PTGE) genes reveals genetic susceptibility for cross-reactive hypersensitivity to NSAID. 61
33450044 2021
30
No pain, still gain (of function): the relation between sensory profiles and the presence or absence of self-reported pain in a large multicenter cohort of patients with neuropathy. 61
32868752 2021
31
China Consensus Document on Allergy Diagnostics. 61
33474855 2021
32
Hypersensitivity Pneumonitis and (Idiopathic) Pulmonary Fibrosis Due to Feather Duvets and Pillows. 61
32059824 2021
33
The Lung Microbiome in Health, Hypersensitivity Pneumonitis, and Idiopathic Pulmonary Fibrosis: A Heavy Bacterial Burden to Bear. 61
32791003 2021
34
The Respiratory Microbiome in Chronic Hypersensitivity Pneumonitis Is Distinct from That of Idiopathic Pulmonary Fibrosis. 61
32692582 2021
35
[The updated S2k guideline for the diagnosis of idiopathic pulmonary fibrosis : Essential aspects for pathology]. 61
33416935 2021
36
Glomus tumors of the upper extremity. 61
33588493 2021
37
Nociceptive afferent phenotyping reveals that transient receptor potential ankyrin 1 promotes cold pain through neurogenic inflammation upstream of the neurotrophic factor receptor GFRα3 and the menthol receptor transient receptor potential melastatin 8. 61
32826761 2021
38
Protective effects of the novel amine-oxidase inhibitor multi-target drug SZV 1287 on streptozotocin-induced beta cell damage and diabetic complications in rats. 61
33338750 2021
39
Optimal management of severe symptomatic gastroesophageal reflux disease. 61
32691466 2021
40
Comparison between nab-paclitaxel and solvent-based taxanes as neoadjuvant therapy in breast cancer: a systematic review and meta-analysis. 61
33541289 2021
41
The HMGB1/RAGE axis induces bone pain associated with colonization of 4T1 mouse breast cancer in bone. 61
33204606 2021
42
Diagnostic accuracy of non-contrast abdominopelvic computed tomography scans in follow-up of breast cancer patients. 61
33306919 2021
43
Absence of metabotropic glutamate receptor homolog(s) accelerates acetylcholine neurotransmission in Caenorhabditis elegans. 61
33493646 2021
44
The Role of the IL-33/ST2 Immune Pathway in Autoimmunity: New Insights and Perspectives. 61
33522348 2021
45
Serum Concentrations of KL-6 in Patients with IPF and Lung Cancer and Serial Measurements of KL-6 in IPF Patients Treated with Antifibrotic Therapy. 61
33572070 2021
46
MGMT Epigenetics: The Influence of Gene Body Methylation and other Insights Derived from Integrated Methylomic, Transcriptomic, and Chromatin Analyses for Various Cancer Types. 61
33535955 2021
47
A spider-venom peptide with multitarget activity on sodium and calcium channels alleviates chronic visceral pain in a model of irritable bowel syndrome. 61
32826759 2021
48
An inherent dysfunction in soluble guanylyl cyclase is present in the airway of severe asthmatics and is associated with aberrant redox enzyme expression and compromised NO-cGMP signaling. 61
33360351 2021
49
Iontophoresis-driven porous microneedle array patch for active transdermal drug delivery. 61
33340733 2021
50
Novel bifunctional hybrid compounds designed to enhance the effects of opioids and antagonize the pronociceptive effects of nonopioid peptides as potent analgesics in a rat model of neuropathic pain. 61
32826750 2021
Sources

Variations for Allergic Disease

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Expression for Allergic Disease

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Search GEO for disease gene expression data for Allergic Disease.
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Pathways for Allergic Disease

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Pathways related to Allergic Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 14.15 TNF TLR4 RNASE3 IL9 IL6 IL5
2
ERK Signaling 63
Show member pathways
 13.94 TNF IL9 IL6 IL5 IL4 IL3
3
PEDF Induced Signaling 63
Show member pathways
 13.77 TSLP TNF TLR4 IL9 IL6 IL5
4
TGF-Beta Pathway 63
Show member pathways
 13.67 TNF IL9 IL6 IL5 IL4 IL3
5
Akt Signaling 63
Show member pathways
 13.56 TNF TLR4 IL9 IL6 IL5 IL4
6
PAK Pathway 63
Show member pathways
 13.47 TNF IL9 IL6 IL5 IL4 IL3
7
Cytokine Signaling in Immune system 65
Show member pathways
 13.43 TNF IL9 IL6 IL5 IL4 IL33
8
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 13.12 TNF TLR4 IL6 IL2 IL1B IFNG
9
PI3K-Akt signaling pathway 36
Show member pathways
 13.06 TNF TLR4 IL6 IL4 IL3 IL2
10
Pathways in cancer 36
12.98 IL6 IL5 IL4 IL3 IL2 IL13
11
Measles 36
Show member pathways
 12.97 TNF TLR4 IL6 IL33 IL2 IL1B
12
NF-KappaB Family Pathway 63
Show member pathways
 12.85 TNF TLR4 IL9 IL6 IL3 IL2
13
Common Cytokine Receptor Gamma-Chain Family Signaling Pathways 64
Show member pathways
 12.83 TNF IL9 IL6 IL4 IL2
14
T cell receptor signaling pathway 36
Show member pathways
 12.79 TNF TLR4 IL9 IL6 IL5 IL4
15
Toll-Like receptor Signaling Pathways 64
Show member pathways
 12.78 TNF TLR4 IL6 IL33 IL1B
16
NF-kappaB Signaling 4
12.76 TNF IL4 IL3 IL2 IL1B IFNG
17
Th17 cell differentiation 36
Show member pathways
 12.68 TNF TLR4 IL6 IL5 IL4 IL2
18
Immune response IL-23 signaling pathway 23
Show member pathways
 12.67 TNF IL6 IL2 IL1B IFNG
19
Immune response Fc epsilon RI pathway 23
Show member pathways
 12.67 TNF IL5 IL4 IL3 IL13
20
JAK-STAT signaling pathway 36
Show member pathways
 12.63 TSLP IL9 IL6 IL5 IL4 IL3
21
Immune response Role of DAP12 receptors in NK cells 23
Show member pathways
 12.61 TNF IL4 IL3 IL2 IFNG
22
IL-17 Family Signaling Pathways 64
Show member pathways
 12.55 TNF IL6 IL5 IL4 IL1B IL13
23
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.49 TNF IL6 IL2 CCR3 CCL22 CCL11
24
Folate Metabolism 1
Show member pathways
 12.48 TNF IL6 IL4 IL2 IL1B IFNG
25
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.44 TNF IL9 IL6 IL5 IL4 IL3
26
Toll Comparative Pathway 63
Show member pathways
 12.43 TNF TLR4 IL6 IL1B IFNG
27
Toxoplasmosis 36
Show member pathways
 12.4 TNF TLR4 IL4 IL1B IFNG
28
Bacterial infections in CF airways 23
Show member pathways
 12.4 TNF TLR4 IL6 IL4 IL1B IFNG
29
Tuberculosis 36
12.38 TNF TLR4 IL6 IL1B IFNG
30
C-type lectin receptor signaling pathway 36
Show member pathways
 12.36 TNF IL6 IL2 IL1B CCL22
31
Necroptosis 36
Show member pathways
 12.35 TNF TLR4 IL33 IL1B IFNG
32
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.33 TNF IL6 IL1B IL13 GATA3
33
NOD-like receptor signaling pathway 36
12.31 TNF TLR4 IL6 IL1B
34
Colorectal Cancer Metastasis 63
12.26 TNF TLR4 IL6 IFNG
35
Yersinia infection 36
12.24 TNF TLR4 IL6 IL2 IL1B
36
Spinal Cord Injury 1
12.24 TNF TLR4 IL6 IL4 IL2 IL1B
37
Allograft rejection 36 1
Show member pathways
 12.21 TNF RNASE3 IL9 IL6 IL5 IL4
38
MAPK Pathway 70
Show member pathways
 12.19 TLR4 IL5 IL2 IL1B IL13
39
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
12.18 TNF IL6 IL5 IL4 IL3 IL2
40
Interleukin-4 and 13 signaling 65
12.15 TNF IL6 IL4 IL1B IL13 GATA3
41
Hematopoietic cell lineage 36
12.12 TNF IL6 IL5 IL4 IL3 IL1B
42
IL12-mediated signaling events 1
Show member pathways
 12.09 IL4 IL2 IL1B IFNG
43
Amoebiasis 36
12.09 TNF TLR4 IL6 IL1B IFNG
44
Senescence and Autophagy in Cancer 1
12.06 IL6 IL3 IL1B IFNG
45
Glucocorticoid receptor regulatory network 1
12.05 IL6 IL5 IL4 IL2 IL13 IFNG
46
Rheumatoid arthritis 36
12.04 TNF TLR4 IL6 IL1B IFNG
47
Th17 Differentiation Pathway 64
Show member pathways
 12.02 TLR4 IL6 IL4 IL1B IFNG
48
Th1 Differentiation Pathway 64
Show member pathways
 12.01 TNF TLR4 IL6 IL2 IL1B IFNG
49
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.94 TNF IL5 IL4 IL3 IL2 IFNG
50
Dendritic Cells Developmental Lineage Pathway 64
11.93 TNF IL6 IL2 IL1B IFNG
Sources

GO Terms for Allergic Disease

About this section

Cellular components related to Allergic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 TSLP TNF RNASE3 IL9 IL6 IL5
2 extracellular space GO:0005615 9.53 TSLP TNF RNASE3 IL9 IL6 IL5

Biological processes related to Allergic Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 93)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.39 TSLP TLR4 IL6 IL5 IL4 IL1B
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.3 TNF TLR4 IL6 IL4 IL33 IL2
3 negative regulation of transcription by RNA polymerase II GO:0000122 10.25 TNF IL4 IL33 IFNG GATA3 FOXP3
4 positive regulation of transcription, DNA-templated GO:0045893 10.23 TNF IL6 IL5 IL4 IL1B GATA3
5 positive regulation of cell proliferation GO:0008284 10.16 TSLP IL9 IL6 IL5 IL4 IL3
6 positive regulation of gene expression GO:0010628 10.13 TNF TLR4 IL6 IL4 IL33 IL1B
7 MAPK cascade GO:0000165 10.11 TNF