MCID: ALL014
MIFTS: 36

Allergic Encephalomyelitis

Categories: Rare diseases, Immune diseases

Aliases & Classifications for Allergic Encephalomyelitis

MalaCards integrated aliases for Allergic Encephalomyelitis:

Name: Allergic Encephalomyelitis 53
Experimental Autoimmune Encephalomyelitis 73

Classifications:



External Ids:

UMLS 73 C0014072

Summaries for Allergic Encephalomyelitis

MalaCards based summary : Allergic Encephalomyelitis, also known as experimental autoimmune encephalomyelitis, is related to optic neuritis and central nervous system disease. An important gene associated with Allergic Encephalomyelitis is MBP (Myelin Basic Protein), and among its related pathways/superpathways are Spinal Cord Injury and Glial Cell Differentiation. The drugs s 1 (combination) and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include t cells, spinal cord and brain, and related phenotypes are cellular and hematopoietic system

Related Diseases for Allergic Encephalomyelitis

Diseases related to Allergic Encephalomyelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 optic neuritis 29.4 MBP MOG PLP1
2 central nervous system disease 29.2 MBP MOG
3 multiple sclerosis 28.9 CXCL10 MBP MOG PLP1
4 nervous system disease 28.8 MBP MOG
5 neuritis 28.7 CXCL10 MBP MOG
6 demyelinating disease 27.7 CXCL10 MBP MOG PLP1
7 niemann-pick disease, type a 10.3 MBP PLP1
8 balo concentric sclerosis 10.2 MBP MOG
9 hereditary neuropathies 10.2 MBP PLP1
10 acute disseminated encephalomyelitis 10.2 MBP MOG
11 panencephalitis, subacute sclerosing 10.2 MBP MOG
12 internuclear ophthalmoplegia 10.2 MBP MOG
13 myelitis 10.2 MBP MOG
14 leukodystrophy, hypomyelinating, 2 10.2 MBP PLP1
15 spinal cord disease 10.2 MBP MOG
16 pelizaeus-merzbacher disease 10.1 MBP PLP1
17 neuromyelitis optica 10.1 MBP MOG
18 orchitis 10.0
19 thyroiditis 10.0
20 autoimmune disease 10.0
21 autoimmune disease 1 10.0
22 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0
23 endotheliitis 10.0
24 optic nerve disease 10.0 MBP MOG
25 relapsing-remitting multiple sclerosis 9.9 MBP MOG
26 aging 9.9
27 pertussis 9.9
28 retinal vasculitis 9.9
29 uveitis 9.9
30 vaccinia 9.9
31 retinitis 9.9
32 neuronitis 9.9
33 vasculitis 9.9
34 tertiary neurosyphilis 9.8 CXCL10 MBP
35 viral encephalitis 9.8 CXCL10 MBP
36 myasthenia gravis 9.7
37 glucocorticoid resistance, generalized 9.7
38 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.7
39 melanoma 9.7
40 b cell deficiency 9.7
41 borna disease 9.7
42 herpes simplex 9.7
43 meningitis 9.7
44 type i 9.7
45 myasthenia gravis congenital 9.7
46 encephalopathy 9.7
47 primary progressive multiple sclerosis 9.7 MBP MOG PLP1
48 secondary progressive multiple sclerosis 9.7 CXCL10 MBP
49 encephalitis 9.3 CXCL10 MOG

Graphical network of the top 20 diseases related to Allergic Encephalomyelitis:



Diseases related to Allergic Encephalomyelitis

Symptoms & Phenotypes for Allergic Encephalomyelitis

MGI Mouse Phenotypes related to Allergic Encephalomyelitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.65 CXCL10 FTH1 MBP MOG PLP1
2 hematopoietic system MP:0005397 9.55 CXCL10 FTH1 MBP MOG PLP1
3 immune system MP:0005387 9.35 CXCL10 FTH1 MBP MOG PLP1
4 nervous system MP:0003631 9.02 CXCL10 FTH1 MBP MOG PLP1

Drugs & Therapeutics for Allergic Encephalomyelitis

Drugs for Allergic Encephalomyelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
s 1 (combination) Phase 1
2
Benzocaine Approved, Investigational Not Applicable 1994-09-7, 94-09-7 2337
3 tannic acid Approved, Nutraceutical Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Mesenchymal Stem Cells for the Treatment of MS Unknown status NCT00781872 Phase 1, Phase 2
2 Evaluation of Autologous Mesenchymal Stem Cell Transplantation (Effects and Side Effects) in Multiple Sclerosis Completed NCT01377870 Phase 1, Phase 2
3 A Study to Assess the Relative Bioavailability of Different Formulations of GSK2018682, a Sphingosine-1-phosphate Receptor Subtype 1 Agonist, in Healthy Volunteers. Completed NCT01466322 Phase 1 GSK2018682 CD2 Capsule; GSK2018682 CD3 non-micronised Tablet; GSK2018682 CD3 micronised Tablet; GSK2018682 CD3 non-micronised Tablet in fed state
4 A Pilot Study of Intermittent Calorie Restriction in Multiple Sclerosis Completed NCT02647502 Not Applicable

Search NIH Clinical Center for Allergic Encephalomyelitis

Genetic Tests for Allergic Encephalomyelitis

Anatomical Context for Allergic Encephalomyelitis

MalaCards organs/tissues related to Allergic Encephalomyelitis:

41
T Cells, Spinal Cord, Brain, B Cells, Bone, Monocytes, Endothelial

Publications for Allergic Encephalomyelitis

Articles related to Allergic Encephalomyelitis:

(show top 50) (show all 1169)
# Title Authors Year
1
Neuroprotective Effects of Melatonin on Experimental Allergic Encephalomyelitis Mice Via Anti-Oxidative Stress Activity. ( 29450696 )
2018
2
Animal models of multiple sclerosis: Focus on experimental autoimmune encephalomyelitis. ( 29446144 )
2018
3
Correction to: Nebulization of RNS60, a Physically-Modified Saline, Attenuates the Adoptive Transfer of Experimental Allergic Encephalomyelitis in Mice: Implications for Multiple Sclerosis Therapy. ( 29611013 )
2018
4
Glatiramer acetate-specific antibody titres in patients with relapsing a88 remitting multiple sclerosis and in experimental autoimmune encephalomyelitis. ( 29939403 )
2018
5
Differential anxiety-like responses in NOD/ShiLtJ and C57BL/6J mice following experimental autoimmune encephalomyelitis induction and oral gavage. ( 29444620 )
2018
6
Metabolomics approaches in experimental allergic encephalomyelitis. ( 29224959 )
2018
7
Dendritic cells, engineered to overexpress 25-hydroxyvitamin D 1I+-hydroxylase and pulsed with a myelin antigen, provide myelin-specific suppression of ongoing experimental allergic encephalomyelitis. ( 28363955 )
2017
8
Behavioral assessment of neuropathic pain, fatigue, and anxiety in experimental autoimmune encephalomyelitis (EAE) and attenuation by interleukin-10 gene therapy. ( 27189037 )
2017
9
Inosine, an Endogenous Purine Nucleoside, Suppresses Immune Responses and Protects Mice from Experimental Autoimmune Encephalomyelitis: a Role for A2A Adenosine Receptor. ( 27130268 )
2017
10
Galectin-8 as an immunosuppressor in experimental autoimmune encephalomyelitis and a target of human early prognostic antibodies in multiple sclerosis. ( 28650992 )
2017
11
Glyceryl Tribenzoate: A Flavoring Ingredient, Inhibits the Adoptive Transfer of Experimental Allergic Encephalomyelitis via TGF-I^: Implications for Multiple Sclerosis Therapy. ( 28367355 )
2017
12
Cyclophilin inhibitor NIM811 ameliorates experimental allergic encephalomyelitis. ( 28789840 )
2017
13
PRMT5-Selective Inhibitors Suppress Inflammatory T Cell Responses and Experimental Autoimmune Encephalomyelitis. ( 28087667 )
2017
14
Thymic-Specific Serine Protease Limits Central Tolerance and Exacerbates Experimental Autoimmune Encephalomyelitis. ( 29061767 )
2017
15
IL-4/IL-13 Heteroreceptor Influences Th17 Cell Conversion and Sensitivity to Regulatory T Cell Suppression To Restrain Experimental Allergic Encephalomyelitis. ( 28801358 )
2017
16
Nebulization of RNS60, a Physically-Modified Saline, Attenuates the Adoptive Transfer of Experimental Allergic Encephalomyelitis in Mice: Implications for Multiple Sclerosis Therapy. ( 28271325 )
2017
17
Effect of dimethyl fumarate on heme oxygenase-1 expression in experimental allergic encephalomyelitis in rats. ( 29363907 )
2017
18
LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis. ( 28028151 )
2017
19
Mir-223 regulates the number and function of myeloid-derived suppressor cells in multiple sclerosis and experimental autoimmune encephalomyelitis. ( 27704281 )
2017
20
Galectin-1 is essential for the induction of MOG35-55 -based intravenous tolerance in experimental autoimmune encephalomyelitis. ( 27151444 )
2016
21
Artesunate Ameliorates Experimental Autoimmune Encephalomyelitis by Inhibiting Leukocyte Migration to the Central Nervous System. ( 27165523 )
2016
22
G-CSF treatment promotes apoptosis of autoreactive T cells to restrict the inflammatory cascade and accelerate recovery in experimental allergic encephalomyelitis. ( 27771353 )
2016
23
Effect of recombinant Lactococcus lactis producing myelin peptides on neuroimmunological changes in rats with experimental allergic encephalomyelitis. ( 27764517 )
2016
24
GDNF Enhances Therapeutic Efficiency of Neural Stem Cells-Based Therapy in Chronic Experimental Allergic Encephalomyelitis in Rat. ( 27212951 )
2016
25
EphrinB1 and EphrinB2 regulate T cell chemotaxis and migration in experimental autoimmune encephalomyelitis and multiple sclerosis. ( 27039370 )
2016
26
Transplantation of Neural Stem Cells Cotreated with Thyroid Hormone and GDNF Gene Induces Neuroprotection in Rats of Chronic Experimental Allergic Encephalomyelitis. ( 26881104 )
2016
27
Regulatory T Cell Dysfunction Acquiesces to BTLA+ Regulatory B Cells Subsequent to Oral Intervention in Experimental Autoimmune Encephalomyelitis. ( 27194787 )
2016
28
Cytokine and chemokine alterations in tissue, CSF, and plasma in early presymptomatic phase of experimental allergic encephalomyelitis (EAE), in a rat model of multiple sclerosis. ( 27846891 )
2016
29
Ncx3 gene ablation impairs oligodendrocyte precursor response and increases susceptibility to experimental autoimmune encephalomyelitis. ( 27120265 )
2016
30
Oligodendroglial TNFR2 Mediates Membrane TNF-Dependent Repair in Experimental Autoimmune Encephalomyelitis by Promoting Oligodendrocyte Differentiation and Remyelination. ( 27147664 )
2016
31
Caveolin-1 Is Critical for Lymphocyte Trafficking into Central Nervous System during Experimental Autoimmune Encephalomyelitis. ( 27170118 )
2016
32
Activation of the adenosine A2A receptor attenuates experimental autoimmune encephalomyelitis and is associated with increased intracellular calcium levels. ( 27217214 )
2016
33
Novel Function of Extracellular Matrix Protein 1 in Suppressing Th17 Cell Development in Experimental Autoimmune Encephalomyelitis. ( 27316685 )
2016
34
Kinematic gait parameters are highly sensitive measures of motor deficits and spinal cord injury in mice subjected to experimental autoimmune encephalomyelitis. ( 27639322 )
2016
35
Oral Tolerance Induction in Experimental Autoimmune Encephalomyelitis with Candida utilis Expressing the Immunogenic MOG35-55 Peptide. ( 27159446 )
2016
36
Correction: Time-Dependent Progression of Demyelination and Axonal Pathology in MP4-Induced Experimental Autoimmune Encephalomyelitis. ( 27144460 )
2016
37
Loss of Nrf2 exacerbates the visual deficits and optic neuritis elicited by experimental autoimmune encephalomyelitis. ( 28050123 )
2016
38
Treatment with retinoid X receptor agonist IRX4204 ameliorates experimental autoimmune encephalomyelitis. ( 27158387 )
2016
39
Capparis ovata treatment suppresses inflammatory cytokine expression and ameliorates experimental allergic encephalomyelitis model of multiple sclerosis in C57BL/6 mice. ( 27609283 )
2016
40
Inflammation severely alters thyroid hormone signaling in the central nervous system during experimental allergic encephalomyelitis in rat: Direct impact on OPCs differentiation failure. ( 27404574 )
2016
41
Hydrogen-rich water improves neurological functional recovery in experimental autoimmune encephalomyelitis mice. ( 27138092 )
2016
42
Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues. ( 27214391 )
2016
43
Enterococcus faecium strain L-3 and glatiramer acetate ameliorate experimental allergic encephalomyelitis in rats by affecting different populations of immune cells. ( 27633171 )
2016
44
Role of TRIF Small Interference RNA (siRNA) in Chronic Experimental Allergic Encephalomyelitis (EAE). ( 26324415 )
2015
45
Effect of oral administration of pig spinal cord hydrolysate on clinical and histopathological symptoms of experimental allergic encephalomyelitis in rats. ( 26216115 )
2015
46
Cinnamon ameliorates experimental allergic encephalomyelitis in mice via regulatory T cells: implications for multiple sclerosis therapy. ( 25569428 )
2015
47
Immune modulation by a tolerogenic myelin oligodendrocyte glycoprotein (MOG)10-60 containing fusion protein in the marmoset experimental autoimmune encephalomyelitis model. ( 25393803 )
2015
48
Analysis of the direct injury effector of oligodendroglia cells or myelin sheath in an experimental allergic encephalomyelitis model induced by the MOG35-55 peptide. ( 26459920 )
2015
49
Exacerbation of experimental autoimmune encephalomyelitis in ceramide synthase 6 knockout mice is associated with enhanced activation/migration of neutrophils. ( 25833068 )
2015
50
Angiopoietin-1 and C16 Peptide Attenuate Vascular and Inflammatory Responses in Experimental Allergic Encephalomyelitis. ( 26553158 )
2015

Variations for Allergic Encephalomyelitis

Expression for Allergic Encephalomyelitis

Search GEO for disease gene expression data for Allergic Encephalomyelitis.

Pathways for Allergic Encephalomyelitis

Pathways related to Allergic Encephalomyelitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.03 CXCL10 MBP
2 9.53 MBP PLP1

GO Terms for Allergic Encephalomyelitis

Cellular components related to Allergic Encephalomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 myelin sheath GO:0043209 8.62 MBP PLP1

Biological processes related to Allergic Encephalomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 central nervous system development GO:0007417 9.32 MBP MOG
2 myelination GO:0042552 9.26 MBP PLP1
3 immune response GO:0006955 9.26 CXCL10 FTH1 HLA-DRA MBP
4 substantia nigra development GO:0021762 9.16 MBP PLP1
5 axon ensheathment GO:0008366 8.62 MBP PLP1

Molecular functions related to Allergic Encephalomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of myelin sheath GO:0019911 8.62 MBP PLP1

Sources for Allergic Encephalomyelitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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