MCID: ALL014
MIFTS: 42

Allergic Encephalomyelitis

Categories: Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Allergic Encephalomyelitis

MalaCards integrated aliases for Allergic Encephalomyelitis:

Name: Allergic Encephalomyelitis 53
Experimental Autoimmune Encephalomyelitis 73

Classifications:



External Ids:

UMLS 73 C0014072

Summaries for Allergic Encephalomyelitis

MalaCards based summary : Allergic Encephalomyelitis, also known as experimental autoimmune encephalomyelitis, is related to multiple sclerosis and neuritis. An important gene associated with Allergic Encephalomyelitis is MBP (Myelin Basic Protein), and among its related pathways/superpathways are Th1 Differentiation Pathway and Interleukin-4 and 13 signaling. The drugs s 1 (combination) and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include t cells, brain and spinal cord, and related phenotypes are cellular and growth/size/body region

Wikipedia : 76 Experimental autoimmune encephalomyelitis, sometimes experimental allergic encephalomyelitis (EAE) is an... more...

Related Diseases for Allergic Encephalomyelitis

Diseases related to Allergic Encephalomyelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 multiple sclerosis 31.0 MBP MOG PLP1
2 neuritis 30.4 MBP MOG
3 demyelinating disease 30.2 MBP MOG PLP1
4 autoimmune disease 30.1 MBP MOG PLP1
5 nervous system disease 29.9 MBP MOG
6 optic neuritis 29.9 MBP MOG PLP1
7 central nervous system disease 29.2 HMOX1 MBP MOG PLP1
8 orchitis 10.2
9 viral infectious disease 10.2
10 pertussis 10.1
11 myelitis 10.1 MBP MOG
12 balo concentric sclerosis 10.1 MBP MOG
13 panencephalitis, subacute sclerosing 10.1 MBP MOG
14 autoimmune disease of peripheral nervous system 10.1 MBP MOG
15 internuclear ophthalmoplegia 10.1 MBP MOG
16 leukodystrophy, hypomyelinating, 2 10.1 MBP PLP1
17 acute disseminated encephalomyelitis 10.0 MBP MOG
18 autoimmune optic neuritis 10.0 MBP MOG
19 spinal cord disease 10.0 MBP MOG
20 pelizaeus-merzbacher disease 10.0 MBP PLP1
21 viral encephalitis 10.0 MBP MOG
22 rabies 10.0
23 retinal vasculitis 10.0
24 uveitis 10.0
25 vaccinia 10.0
26 vasculitis 10.0
27 neuromyelitis optica 10.0 MBP MOG
28 cranial nerve disease 10.0 MBP MOG
29 megalencephalic leukoencephalopathy with subcortical cysts 1 10.0 PLP1 TYK2
30 optic nerve disease 10.0 MBP MOG
31 relapsing-remitting multiple sclerosis 9.9 MBP MOG
32 primary progressive multiple sclerosis 9.9 MBP MOG PLP1
33 immune system disease 9.9 MBP MOG
34 autoimmune disease of central nervous system 9.9 MBP MOG PLP1
35 autoimmune disease of the nervous system 9.9 MBP MOG PLP1
36 myasthenia gravis 9.9
37 autoimmune disease 1 9.9
38 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.9
39 alpha-2-macroglobulin deficiency 9.9
40 glucocorticoid resistance, generalized 9.9
41 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.9
42 hepatitis 9.9
43 epilepsy 9.9
44 melanoma 9.9
45 shwartzman phenomenon 9.9
46 borna disease 9.9
47 herpes simplex 9.9
48 measles 9.9
49 encephalitis 9.9
50 hyperphenylalaninemia 9.9

Graphical network of the top 20 diseases related to Allergic Encephalomyelitis:



Diseases related to Allergic Encephalomyelitis

Symptoms & Phenotypes for Allergic Encephalomyelitis

MGI Mouse Phenotypes related to Allergic Encephalomyelitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.65 HMOX1 MBP MOG PLP1 TYK2
2 growth/size/body region MP:0005378 9.55 HMOX1 MBP MOG PLP1 TYK2
3 hematopoietic system MP:0005397 9.35 HMOX1 MBP MOG PLP1 TYK2
4 immune system MP:0005387 9.02 HMOX1 MBP MOG PLP1 TYK2

Drugs & Therapeutics for Allergic Encephalomyelitis

Drugs for Allergic Encephalomyelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
s 1 (combination) Phase 1
2
Benzocaine Approved, Investigational Not Applicable 94-09-7, 1994-09-7 2337
3 tannic acid Approved Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Mesenchymal Stem Cells for the Treatment of MS Unknown status NCT00781872 Phase 1, Phase 2
2 Evaluation of Autologous Mesenchymal Stem Cell Transplantation (Effects and Side Effects) in Multiple Sclerosis Completed NCT01377870 Phase 1, Phase 2
3 Safety and Tolerability of ISX (Isoxsuprine HCL) in MS Relapses Recruiting NCT03752307 Phase 1, Phase 2 Isoxsuprine Hydrochloride;Placebo;Corticosteroid
4 A Study to Assess the Relative Bioavailability of Different Formulations of GSK2018682, a Sphingosine-1-phosphate Receptor Subtype 1 Agonist, in Healthy Volunteers. Completed NCT01466322 Phase 1 GSK2018682 CD2 Capsule; GSK2018682 CD3 non-micronised Tablet; GSK2018682 CD3 micronised Tablet; GSK2018682 CD3 non-micronised Tablet in fed state
5 A Pilot Study of Intermittent Calorie Restriction in Multiple Sclerosis Completed NCT02647502 Not Applicable

Search NIH Clinical Center for Allergic Encephalomyelitis

Genetic Tests for Allergic Encephalomyelitis

Anatomical Context for Allergic Encephalomyelitis

MalaCards organs/tissues related to Allergic Encephalomyelitis:

41
T Cells, Brain, Spinal Cord, B Cells, Bone, Endothelial, Myeloid

Publications for Allergic Encephalomyelitis

Articles related to Allergic Encephalomyelitis:

(show top 50) (show all 2430)
# Title Authors Year
1
Bacoside-A inhibits inflammatory cytokines and chemokine in experimental autoimmune encephalomyelitis. ( 30551384 )
2019
2
Beneficial effects of Thymus vulgaris extract in experimental autoimmune encephalomyelitis: Clinical, histological and cytokine alterations. ( 30551467 )
2019
3
Enriched environment regulates thymocyte development and alleviates experimental autoimmune encephalomyelitis in mice. ( 30287389 )
2019
4
Astragaloside IV regulates differentiation and induces apoptosis of activated CD4+ T cells in the pathogenesis of experimental autoimmune encephalomyelitis. ( 30385269 )
2019
5
Neuroprotective Effects of Melatonin on Experimental Allergic Encephalomyelitis Mice Via Anti-Oxidative Stress Activity. ( 29450696 )
2018
6
Animal models of multiple sclerosis: Focus on experimental autoimmune encephalomyelitis. ( 29446144 )
2018
7
Correction to: Nebulization of RNS60, a Physically-Modified Saline, Attenuates the Adoptive Transfer of Experimental Allergic Encephalomyelitis in Mice: Implications for Multiple Sclerosis Therapy. ( 29611013 )
2018
8
Glatiramer acetate-specific antibody titres in patients with relapsing a88 remitting multiple sclerosis and in experimental autoimmune encephalomyelitis. ( 29939403 )
2018
9
Differential anxiety-like responses in NOD/ShiLtJ and C57BL/6J mice following experimental autoimmune encephalomyelitis induction and oral gavage. ( 29444620 )
2018
10
Metabolomics approaches in experimental allergic encephalomyelitis. ( 29224959 )
2018
11
Amelioration of Experimental autoimmune encephalomyelitis and DSS induced colitis by NTG-A-009 through the inhibition of Th1 and Th17 cells differentiation. ( 29773813 )
2018
12
The Short and Long-Term Effects of Pregnancy on Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis. ( 30486504 )
2018
13
Emerging Role of Follicular T Helper Cells in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis. ( 30347676 )
2018
14
Reduced expression of the ferroptosis inhibitor glutathione peroxidase-4 in multiple sclerosis and experimental autoimmune encephalomyelitis. ( 30289974 )
2018
15
Rapamycin combined with MCC950 to treat multiple sclerosis in experimental autoimmune encephalomyelitis. ( 30320900 )
2018
16
Re-examining the potential of targeting ABHD6 in multiple sclerosis: Efficacy of systemic and peripherally restricted inhibitors in experimental autoimmune encephalomyelitis. ( 30171986 )
2018
17
Cannabidiol Attenuates Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis Through Induction of Myeloid-Derived Suppressor Cells. ( 30123217 )
2018
18
Role of nuclear factor κB in multiple sclerosis and experimental autoimmune encephalomyelitis. ( 30127103 )
2018
19
Early alpha-lipoic acid therapy protects from degeneration of the inner retinal layers and vision loss in an experimental autoimmune encephalomyelitis-optic neuritis model. ( 29514678 )
2018
20
Auto-Reactive Th17-Cells Trigger Obsessive-Compulsive-Disorder Like Behavior in Mice With Experimental Autoimmune Encephalomyelitis. ( 30429853 )
2018
21
Spasticity Treatment Ameliorates the Efficacy of Melatonin Therapy in Experimental Autoimmune Encephalomyelitis (EAE) Mouse Model of Multiple Sclerosis. ( 29497878 )
2018
22
Hydrogen-Rich Saline Ameliorates Experimental Autoimmune Encephalomyelitis in C57BL/6 Mice Via the Nrf2-ARE Signaling Pathway. ( 30343391 )
2018
23
Publisher Correction: Maladaptive cortical hyperactivity upon recovery from experimental autoimmune encephalomyelitis. ( 30405214 )
2018
24
MicroRNA-92a Drives Th1 Responses in the Experimental Autoimmune Encephalomyelitis. ( 30411211 )
2018
25
Pien Tze Huang Alleviates Relapsing-Remitting Experimental Autoimmune Encephalomyelitis Mice by Regulating Th1 and Th17 Cells. ( 30429789 )
2018
26
Enhanced GABAergic Tonic Inhibition Reduces Intrinsic Excitability of Hippocampal CA1 Pyramidal Cells in Experimental Autoimmune Encephalomyelitis. ( 30447391 )
2018
27
Endothelial Microsomal Prostaglandin E Synthetase-1 Upregulates Vascularity and Endothelial Interleukin-1β in Deteriorative Progression of Experimental Autoimmune Encephalomyelitis. ( 30463256 )
2018
28
Connexin 30 Deficiency Attenuates Chronic but Not Acute Phases of Experimental Autoimmune Encephalomyelitis Through Induction of Neuroprotective Microglia. ( 30464764 )
2018
29
Macrophage CD40-signaling drives experimental autoimmune encephalomyelitis. ( 30471110 )
2018
30
Carvacrol ameliorates experimental autoimmune encephalomyelitis through modulating pro- and anti-inflammatory cytokines. ( 30472298 )
2018
31
Cytokines as Mediators of Neuroinflammation in Experimental Autoimmune Encephalomyelitis. ( 30472948 )
2018
32
Aspirin ameliorates experimental autoimmune encephalomyelitis through interleukin-11-mediated protection of regulatory T cells. ( 30482850 )
2018
33
PD-1 expression is upregulated on adapted T cells in experimental autoimmune encephalomyelitis but is not required to maintain a hyporesponsive state. ( 30485411 )
2018
34
Attenuation of Experimental Autoimmune Encephalomyelitis in a Common Marmoset Model by Dendritic Cell-Modulating Anti-ICAM-1 Antibody, MD-3. ( 30488167 )
2018
35
Regular Exercise Modifies Histopathological Outcomes of Pharmacological Treatment in Experimental Autoimmune Encephalomyelitis. ( 30524355 )
2018
36
Voluntary wheel running reveals sex specific nociceptive factors in murine experimental autoimmune encephalomyelitis. ( 30540622 )
2018
37
The miRNA Expression Profile of Experimental Autoimmune Encephalomyelitis Reveals Novel Potential Disease Biomarkers. ( 30544973 )
2018
38
Activation of astrocytes and expression of inflammatory cytokines in rats with experimental autoimmune encephalomyelitis. ( 30546391 )
2018
39
Therapeutic potentials of the Rho kinase inhibitor Fasudil in experimental autoimmune encephalomyelitis and the related mechanisms. ( 30552558 )
2018
40
Immune response in the relapsing-remitting experimental autoimmune encephalomyelitis in mice: The role of the NF-κB signaling pathway. ( 30553438 )
2018
41
A novel PADRE-Kv1.3 vaccine effectively induces therapeutic antibodies and ameliorates experimental autoimmune encephalomyelitis in rats. ( 29496642 )
2018
42
Recombinant thrombomodulin ameliorates experimental autoimmune encephalomyelitis by suppressing high mobility group box 1 and inflammatory cytokines. ( 29509323 )
2018
43
Evaluation of Marijuana Compounds on Neuroimmune Endpoints in Experimental Autoimmune Encephalomyelitis. ( 29512125 )
2018
44
Mechanism by which Regulatory Rheumatoid Factor Prevents Experimental Autoimmune Encephalomyelitis. ( 29521254 )
2018
45
The therapeutic effect of anti-CD52 treatment in murine experimental autoimmune encephalomyelitis is associated with altered IL-33 and ST2 expression levels. ( 29526407 )
2018
46
Efficacy of Synthetic Peptide Corresponding to the ACTH-Like Sequence of Human Immunoglobulin G1 in Experimental Autoimmune Encephalomyelitis. ( 29527165 )
2018
47
Schlafen-8 is essential for lymphatic endothelial cell activation in experimental autoimmune encephalomyelitis. ( 29528433 )
2018
48
Neuregulin1 modulation of experimental autoimmune encephalomyelitis (EAE). ( 29534847 )
2018
49
Differential Expression of Klotho in the Brain and Spinal Cord is Associated with Total Antioxidant Capacity in Mice with Experimental Autoimmune Encephalomyelitis. ( 29542092 )
2018
50
MicroRNA-181c promotes Th17 cell differentiation and mediates experimental autoimmune encephalomyelitis. ( 29545117 )
2018

Variations for Allergic Encephalomyelitis

Expression for Allergic Encephalomyelitis

Search GEO for disease gene expression data for Allergic Encephalomyelitis.

Pathways for Allergic Encephalomyelitis

Pathways related to Allergic Encephalomyelitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.44 HLA-DRA TYK2
2 11.31 HMOX1 TYK2
3
Show member pathways
11.21 HLA-DRA TYK2
4 10.5 HMOX1 TYK2
5 9.53 MBP PLP1

GO Terms for Allergic Encephalomyelitis

Cellular components related to Allergic Encephalomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 myelin sheath GO:0043209 8.62 MBP PLP1

Biological processes related to Allergic Encephalomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 T cell receptor signaling pathway GO:0050852 9.32 HLA-DRA MOG
2 central nervous system development GO:0007417 9.26 MBP MOG
3 myelination GO:0042552 9.16 MBP PLP1
4 substantia nigra development GO:0021762 8.96 MBP PLP1
5 axon ensheathment GO:0008366 8.62 MBP PLP1

Molecular functions related to Allergic Encephalomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of myelin sheath GO:0019911 8.62 MBP PLP1

Sources for Allergic Encephalomyelitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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