MCID: ALL014
MIFTS: 43

Allergic Encephalomyelitis

Categories: Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Allergic Encephalomyelitis

MalaCards integrated aliases for Allergic Encephalomyelitis:

Name: Allergic Encephalomyelitis 54
Experimental Autoimmune Encephalomyelitis 74

Classifications:



External Ids:

UMLS 74 C0014072

Summaries for Allergic Encephalomyelitis

MalaCards based summary : Allergic Encephalomyelitis, also known as experimental autoimmune encephalomyelitis, is related to neuritis and multiple sclerosis. An important gene associated with Allergic Encephalomyelitis is MBP (Myelin Basic Protein), and among its related pathways/superpathways are Th1 Differentiation Pathway and G-protein signaling Ras family GTPases in kinase cascades (scheme). The drugs Methylprednisolone and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include t cells, brain and spinal cord, and related phenotypes are Negative genetic interaction between BLM-/- and BLM+/+ and cellular

Wikipedia : 77 Experimental autoimmune encephalomyelitis, sometimes experimental allergic encephalomyelitis (EAE) is an... more...

Related Diseases for Allergic Encephalomyelitis

Diseases related to Allergic Encephalomyelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Related Disease Score Top Affiliating Genes
1 neuritis 30.9 MBP MOG
2 multiple sclerosis 30.4 CD86 MBP MOG PLP1
3 demyelinating disease 30.2 MBP MOG PLP1
4 optic neuritis 30.0 MBP MOG PLP1
5 nervous system disease 30.0 MBP MOG
6 central nervous system disease 29.6 MBP MOG PLP1
7 pertussis 10.4
8 autoimmune disease 10.2
9 arthritis 10.2
10 orchitis 10.2
11 myelitis 10.1 MBP MOG
12 autoimmune disease 1 10.1
13 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.1
14 uveitis 10.1
15 thyroiditis 10.1
16 vasculitis 10.1
17 bowenoid papulosis 10.1
18 encephalopathy 10.1
19 balo concentric sclerosis 10.1 MBP MOG
20 panencephalitis, subacute sclerosing 10.1 MBP MOG
21 autoimmune disease of peripheral nervous system 10.1 MBP MOG
22 internuclear ophthalmoplegia 10.1 MBP MOG
23 leukodystrophy, hypomyelinating, 2 10.1 MBP PLP1
24 acute disseminated encephalomyelitis 10.1 MBP MOG
25 autoimmune optic neuritis 10.1 MBP MOG
26 spinal cord disease 10.0 MBP MOG
27 pelizaeus-merzbacher disease 10.0 MBP PLP1
28 rabies 10.0
29 retinal vasculitis 10.0
30 vaccinia 10.0
31 herpes simplex 10.0
32 measles 10.0
33 encephalitis 10.0
34 lymphomatous thyroiditis 10.0
35 neuromyelitis optica 10.0 MBP MOG
36 cranial nerve disease 10.0 MBP MOG
37 optic nerve disease 10.0 MBP MOG
38 relapsing-remitting multiple sclerosis 9.9 MBP MOG
39 elastosis perforans serpiginosa 9.9
40 glioma susceptibility 1 9.9
41 laryngeal adductor paralysis 9.9
42 smith-magenis syndrome 9.9
43 myasthenia gravis 9.9
44 salla disease 9.9
45 glucocorticoid resistance, generalized 9.9
46 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.9
47 sclerosing cholangitis, neonatal 9.9
48 hepatitis 9.9
49 sarcoma 9.9
50 epilepsy 9.9

Graphical network of the top 20 diseases related to Allergic Encephalomyelitis:



Diseases related to Allergic Encephalomyelitis

Symptoms & Phenotypes for Allergic Encephalomyelitis

GenomeRNAi Phenotypes related to Allergic Encephalomyelitis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Negative genetic interaction between BLM-/- and BLM+/+ GR00255-A-1 8.8 CD86 JAK2 MBP

MGI Mouse Phenotypes related to Allergic Encephalomyelitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.85 CD86 JAK2 MBP MOG PLP1 PPARG
2 behavior/neurological MP:0005386 9.8 CD86 MBP MOG PLP1 PPARG
3 hematopoietic system MP:0005397 9.8 CD86 JAK2 MBP MOG PLP1 PPARG
4 immune system MP:0005387 9.73 CD86 JAK2 MBP MOG PLP1 PPARG
5 muscle MP:0005369 9.46 CD86 MOG PLP1 PPARG
6 nervous system MP:0003631 9.35 CD86 MBP MOG PLP1 PPARG
7 vision/eye MP:0005391 8.92 MBP MOG PLP1 PPARG

Drugs & Therapeutics for Allergic Encephalomyelitis

Drugs for Allergic Encephalomyelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 1, Phase 2 83-43-2 6741
2
Prednisone Approved, Vet_approved Phase 1, Phase 2 53-03-2 5865
3
Methylprednisolone hemisuccinate Approved Phase 1, Phase 2 2921-57-5
4
Prednisolone phosphate Approved, Vet_approved Phase 1, Phase 2 302-25-0
5
Prednisolone Approved, Vet_approved Phase 1, Phase 2 50-24-8 5755
6
Prednisolone hemisuccinate Experimental Phase 1, Phase 2 2920-86-7
7 Sympathomimetics Phase 1, Phase 2
8 Antineoplastic Agents, Hormonal Phase 1, Phase 2
9 glucocorticoids Phase 1, Phase 2
10 Adrenergic Agonists Phase 1, Phase 2
11 Tocolytic Agents Phase 1, Phase 2
12 Neuroprotective Agents Phase 1, Phase 2
13 Neurotransmitter Agents Phase 1, Phase 2
14 Peripheral Nervous System Agents Phase 1, Phase 2
15 Gastrointestinal Agents Phase 1, Phase 2
16 Hormone Antagonists Phase 1, Phase 2
17 Adrenergic Agents Phase 1, Phase 2
18 Vasodilator Agents Phase 1, Phase 2
19 Antiemetics Phase 1, Phase 2
20 Methylprednisolone Acetate Phase 1, Phase 2
21 Protective Agents Phase 1, Phase 2
22 Autonomic Agents Phase 1, Phase 2
23 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
24 Hormones Phase 1, Phase 2
25 Anti-Inflammatory Agents Phase 1, Phase 2
26 Prednisolone acetate Phase 1, Phase 2
27 Adrenergic beta-Agonists Phase 1, Phase 2
28
s 1 (combination) Phase 1
29
Benzocaine Approved, Investigational Not Applicable 1994-09-7, 94-09-7 2337
30
tannic acid Approved Not Applicable 1401-55-4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Mesenchymal Stem Cells for the Treatment of MS Unknown status NCT00781872 Phase 1, Phase 2
2 Evaluation of Autologous Mesenchymal Stem Cell Transplantation (Effects and Side Effects) in Multiple Sclerosis Completed NCT01377870 Phase 1, Phase 2
3 Safety and Tolerability of ISX (Isoxsuprine HCL) in MS Relapses Recruiting NCT03752307 Phase 1, Phase 2 Isoxsuprine Hydrochloride;Placebo;Corticosteroid
4 A Study to Assess the Relative Bioavailability of Different Formulations of GSK2018682, a Sphingosine-1-phosphate Receptor Subtype 1 Agonist, in Healthy Volunteers. Completed NCT01466322 Phase 1 GSK2018682 CD2 Capsule; GSK2018682 CD3 non-micronised Tablet; GSK2018682 CD3 micronised Tablet; GSK2018682 CD3 non-micronised Tablet in fed state
5 A Pilot Study of Intermittent Calorie Restriction in Multiple Sclerosis Completed NCT02647502 Not Applicable

Search NIH Clinical Center for Allergic Encephalomyelitis

Genetic Tests for Allergic Encephalomyelitis

Anatomical Context for Allergic Encephalomyelitis

MalaCards organs/tissues related to Allergic Encephalomyelitis:

42
T Cells, Brain, Spinal Cord, B Cells, Bone, Endothelial, Lymph Node

Publications for Allergic Encephalomyelitis

Articles related to Allergic Encephalomyelitis:

(show top 50) (show all 5038)
# Title Authors Year
1
Passive transfer of allergic encephalomyelitis in rats: a tool for drug mechanism studies and detecting late-acting immunosuppressants. ( 30778876 )
2019
2
Repetitive intrathecal injection of human NMO-IgG with complement exacerbates disease severity with NMO pathology in experimental allergic encephalomyelitis mice. ( 30825702 )
2019
3
Corrigendum: A Perspective of Coagulation Dysfunction in Multiple Sclerosis and in Experimental Allergic Encephalomyelitis. ( 30949115 )
2019
4
Prevention of clinical and histological signs of MOG-induced experimental allergic encephalomyelitis by prolonged treatment with recombinant human EGF. ( 31100693 )
2019
5
Platelet Depletion is Effective in Ameliorating Anxiety-Like Behavior and Reducing the Pro-Inflammatory Environment in the Hippocampus in Murine Experimental Autoimmune Encephalomyelitis. ( 30717130 )
2019
6
Novel insights into the mechanisms underlying depression-associated experimental autoimmune encephalomyelitis. ( 30849414 )
2019
7
Dietary Modulation of Intestinal Microbiota: Future Opportunities in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis. ( 31040833 )
2019
8
γδ T lymphocytes in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis. ( 30831520 )
2019
9
The contribution of astrocytes to the neuroinflammatory response in multiple sclerosis and experimental autoimmune encephalomyelitis. ( 30847559 )
2019
10
Characterization of leptomeningeal inflammation in rodent experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis. ( 30684521 )
2019
11
Rapamycin combined with MCC950 to treat multiple sclerosis in experimental autoimmune encephalomyelitis. ( 30320900 )
2019
12
Reduced expression of the ferroptosis inhibitor glutathione peroxidase-4 in multiple sclerosis and experimental autoimmune encephalomyelitis. ( 30289974 )
2019
13
The therapeutic effect of platelet-rich plasma on the experimental autoimmune encephalomyelitis mice. ( 31103935 )
2019
14
Hydrogen-Rich Saline Ameliorates Experimental Autoimmune Encephalomyelitis in C57BL/6 Mice Via the Nrf2-ARE Signaling Pathway. ( 30343391 )
2019
15
Gold Nanoparticles and Polyethylene Glycol Alleviate Clinical Symptoms and Alter Cytokine Secretion in a Mouse Model of Experimental Autoimmune Encephalomyelitis. ( 30957389 )
2019
16
Beneficial effects of Thymus vulgaris extract in experimental autoimmune encephalomyelitis: Clinical, histological and cytokine alterations. ( 30551467 )
2019
17
Regulatory T Cells and Their Derived Cytokine, Interleukin-35, Reduce Pain in Experimental Autoimmune Encephalomyelitis. ( 30651334 )
2019
18
Ethanol extract of Glycyrrhizae Radix modulates the responses of antigen-specific splenocytes in experimental autoimmune encephalomyelitis. ( 30668383 )
2019
19
Neuron-specific PERK inactivation exacerbates neurodegeneration during experimental autoimmune encephalomyelitis. ( 30674717 )
2019
20
Absence of endothelial α5β1 integrin triggers early onset of experimental autoimmune encephalomyelitis due to reduced vascular remodeling and compromised vascular integrity. ( 30678721 )
2019
21
Akt-1 and Akt-2 Differentially Regulate the Development of Experimental Autoimmune Encephalomyelitis by Controlling Proliferation of Thymus-Derived Regulatory T Cells. ( 30692211 )
2019
22
Therapeutic potential of conditioned medium derived from oligodendrocytes cultured in a self-assembling peptide nanoscaffold in experimental autoimmune encephalomyelitis. ( 30703369 )
2019
23
Microglia pre-activation and neurodegeneration precipitate neuroinflammation without exacerbating tissue injury in experimental autoimmune encephalomyelitis. ( 30704526 )
2019
24
MiR-146a promotes oligodendrocyte progenitor cell differentiation and enhances remyelination in a model of experimental autoimmune encephalomyelitis. ( 30707940 )
2019
25
p38MAPK/SGK1 signaling regulates macrophage polarization in experimental autoimmune encephalomyelitis. ( 30716717 )
2019
26
P-glycoprotein Inhibitor Tariquidar Potentiates Efficacy of Astragaloside IV in Experimental Autoimmune Encephalomyelitis Mice. ( 30717494 )
2019
27
Quantitative Proteome Analysis of Brain Subregions and Spinal Cord from Experimental Autoimmune Encephalomyelitis Mice by TMT-Based Mass Spectrometry. ( 30724464 )
2019
28
Adjuvant and antigenic properties of Mycobacterium avium subsp. paratuberculosis on experimental autoimmune encephalomyelitis. ( 30738572 )
2019
29
Docosahexaenoic acid (22:6n-3) Ameliorated the Onset and Severity of Experimental Autoimmune Encephalomyelitis in Mice. ( 30762234 )
2019
30
Frontline Science: Induction of experimental autoimmune encephalomyelitis mobilizes Th17-promoting myeloid derived suppressor cells to the lung. ( 30762897 )
2019
31
Localization of near-infrared labeled antibodies to the central nervous system in experimental autoimmune encephalomyelitis. ( 30768649 )
2019
32
Nasal delivery of Fasudil-modified immune cells exhibits therapeutic potential in experimental autoimmune encephalomyelitis. ( 30779332 )
2019
33
Celastrol suppresses experimental autoimmune encephalomyelitis via MAPK/SGK1-regulated mediators of autoimmune pathology. ( 30820608 )
2019
34
Amlexanox attenuates experimental autoimmune encephalomyelitis by inhibiting dendritic cell maturation and reprogramming effector and regulatory T cell responses. ( 30823934 )
2019
35
Axonal damage in spinal cord is associated with gray matter atrophy in sensorimotor cortex in experimental autoimmune encephalomyelitis. ( 30843756 )
2019
36
SFX-01 reduces residual disability after experimental autoimmune encephalomyelitis. ( 30851639 )
2019
37
The therapeutic potential of ginkgolide K in experimental autoimmune encephalomyelitis via peripheral immunomodulation. ( 30851709 )
2019
38
Systemic exposure to a single dose of ferucarbotran aggravates neuroinflammation in a murine model of experimental autoimmune encephalomyelitis. ( 30863056 )
2019
39
Systemic administration of orexin A ameliorates established experimental autoimmune encephalomyelitis by diminishing neuroinflammation. ( 30894198 )
2019
40
Lactobacillus reuteri Reduces the Severity of Experimental Autoimmune Encephalomyelitis in Mice by Modulating Gut Microbiota. ( 30899262 )
2019
41
The Genetic Background of Mice Influences the Effects of Cigarette Smoke on Onset and Severity of Experimental Autoimmune Encephalomyelitis. ( 30901861 )
2019
42
A CD40 targeting peptide prevents severe symptoms in experimental autoimmune encephalomyelitis. ( 30925295 )
2019
43
T-cell repertoire profiling by next-generation sequencing reveals tissue migration dynamics of TRBV13-family clonotypes in a common experimental autoimmune encephalomyelitis mouse model. ( 30933850 )
2019
44
Regulatory effects of hemp seed/evening primrose oil supplement in comparison with rapamycin on the expression of the mammalian target of rapamycin-complex 2 and interleukin-10 genes in experimental autoimmune encephalomyelitis. ( 30936931 )
2019
45
Abrogation of Endogenous Glycolipid Antigen Presentation on Myelin-Laden Macrophages by D-Sphingosine Ameliorates the Pathogenesis of Experimental Autoimmune Encephalomyelitis. ( 30941120 )
2019
46
Effects of Oenothera biennis L. and Hypericum perforatum L. extracts on some central nervous system myelin proteins, brain histopathology and oxidative stress in mice with experimental autoimmune encephalomyelitis. ( 30957550 )
2019
47
Altered expression patterns of complement factor H and miR-146a genes in acute-chronic phases in experimental autoimmune encephalomyelitis mouse. ( 30972735 )
2019
48
Cerebrospinal Fluid (CSF) Exchange with Artificial CSF Enriched with Mesenchymal Stem Cell Secretions Ameliorates Experimental Autoimmune Encephalomyelitis. ( 30978957 )
2019
49
The PD-1/PD-Ls pathway is up-regulated during the suppression of experimental autoimmune encephalomyelitis treated by Astragalus polysaccharides. ( 30981049 )
2019
50
Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo. ( 30985749 )
2019

Variations for Allergic Encephalomyelitis

Expression for Allergic Encephalomyelitis

Search GEO for disease gene expression data for Allergic Encephalomyelitis.

Pathways for Allergic Encephalomyelitis

GO Terms for Allergic Encephalomyelitis

Biological processes related to Allergic Encephalomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 central nervous system development GO:0007417 9.46 MBP MOG
2 positive regulation of DNA-binding transcription factor activity GO:0051091 9.43 JAK2 PPARG
3 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.4 JAK2 PPARG
4 viral entry into host cell GO:0046718 9.37 CD86 MOG
5 hormone-mediated signaling pathway GO:0009755 9.32 JAK2 PPARG
6 myelination GO:0042552 9.26 MBP PLP1
7 substantia nigra development GO:0021762 9.16 MBP PLP1
8 positive regulation of DNA binding GO:0043388 8.96 JAK2 PPARG
9 axon ensheathment GO:0008366 8.62 MBP PLP1

Molecular functions related to Allergic Encephalomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 8.96 CD86 MOG
2 structural constituent of myelin sheath GO:0019911 8.62 MBP PLP1

Sources for Allergic Encephalomyelitis

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