MCID: ALL014
MIFTS: 43

Allergic Encephalomyelitis

Categories: Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Allergic Encephalomyelitis

MalaCards integrated aliases for Allergic Encephalomyelitis:

Name: Allergic Encephalomyelitis 54
Experimental Autoimmune Encephalomyelitis 74

Classifications:



External Ids:

UMLS 74 C0014072

Summaries for Allergic Encephalomyelitis

MalaCards based summary : Allergic Encephalomyelitis, also known as experimental autoimmune encephalomyelitis, is related to neuritis and demyelinating disease. An important gene associated with Allergic Encephalomyelitis is MBP (Myelin Basic Protein), and among its related pathways/superpathways are Toxoplasmosis and Tuberculosis. The drugs Prednisolone phosphate and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include t cells, brain and spinal cord, and related phenotypes are Negative genetic interaction between BLM-/- and BLM+/+ and cellular

Wikipedia : 77 Experimental autoimmune encephalomyelitis, sometimes experimental allergic encephalomyelitis (EAE) is an... more...

Related Diseases for Allergic Encephalomyelitis

Diseases related to Allergic Encephalomyelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 neuritis 30.8 MBP MOG
2 demyelinating disease 30.1 MBP MOG PLP1
3 multiple sclerosis 30.1 CIITA MBP MOG NOS2 PLP1
4 optic neuritis 29.9 MBP MOG PLP1
5 nervous system disease 29.4 MBP MOG NOS2
6 central nervous system disease 29.0 MBP MOG NOS2 PLP1
7 pertussis 10.4
8 autoimmune disease 10.2
9 arthritis 10.2
10 orchitis 10.2
11 myelitis 10.1 MBP MOG
12 autoimmune disease 1 10.1
13 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.1
14 uveitis 10.1
15 thyroiditis 10.1
16 vasculitis 10.1
17 bowenoid papulosis 10.1
18 encephalopathy 10.1
19 balo concentric sclerosis 10.1 MBP MOG
20 panencephalitis, subacute sclerosing 10.1 MBP MOG
21 autoimmune disease of peripheral nervous system 10.1 MBP MOG
22 internuclear ophthalmoplegia 10.1 MBP MOG
23 leukodystrophy, hypomyelinating, 2 10.1 MBP PLP1
24 acute disseminated encephalomyelitis 10.1 MBP MOG
25 autoimmune optic neuritis 10.0 MBP MOG
26 spinal cord disease 10.0 MBP MOG
27 pelizaeus-merzbacher disease 10.0 MBP PLP1
28 rabies 10.0
29 retinal vasculitis 10.0
30 vaccinia 10.0
31 herpes simplex 10.0
32 measles 10.0
33 encephalitis 10.0
34 lymphomatous thyroiditis 10.0
35 neuromyelitis optica 10.0 MBP MOG
36 cranial nerve disease 10.0 MBP MOG
37 optic nerve disease 9.9 MBP MOG
38 relapsing-remitting multiple sclerosis 9.9 MBP MOG
39 glioma susceptibility 1 9.9
40 myasthenia gravis 9.9
41 salla disease 9.9
42 alpha-2-macroglobulin deficiency 9.9
43 glucocorticoid resistance, generalized 9.9
44 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.9
45 sclerosing cholangitis, neonatal 9.9
46 hepatitis 9.9
47 sarcoma 9.9
48 epilepsy 9.9
49 melanoma 9.9
50 glioblastoma multiforme 9.9

Graphical network of the top 20 diseases related to Allergic Encephalomyelitis:



Diseases related to Allergic Encephalomyelitis

Symptoms & Phenotypes for Allergic Encephalomyelitis

GenomeRNAi Phenotypes related to Allergic Encephalomyelitis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Negative genetic interaction between BLM-/- and BLM+/+ GR00255-A-1 8.8 CIITA JAK2 MBP

MGI Mouse Phenotypes related to Allergic Encephalomyelitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.65 JAK2 MBP MOG NOS2 PLP1
2 hematopoietic system MP:0005397 9.63 CIITA JAK2 MBP MOG NOS2 PLP1
3 immune system MP:0005387 9.43 CIITA JAK2 MBP MOG NOS2 PLP1
4 vision/eye MP:0005391 8.92 MBP MOG NOS2 PLP1

Drugs & Therapeutics for Allergic Encephalomyelitis

Drugs for Allergic Encephalomyelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 1, Phase 2 302-25-0
2
Prednisolone Approved, Vet_approved Phase 1, Phase 2 50-24-8 5755
3
Prednisone Approved, Vet_approved Phase 1, Phase 2 53-03-2 5865
4
Methylprednisolone Approved, Vet_approved Phase 1, Phase 2 83-43-2 6741
5
Methylprednisolone hemisuccinate Approved Phase 1, Phase 2 2921-57-5
6
Prednisolone hemisuccinate Experimental Phase 1, Phase 2 2920-86-7
7 Vasodilator Agents Phase 1, Phase 2
8 Prednisolone acetate Phase 1, Phase 2
9 Adrenergic beta-Agonists Phase 1, Phase 2
10 Peripheral Nervous System Agents Phase 1, Phase 2
11 Anti-Inflammatory Agents Phase 1, Phase 2
12 Tocolytic Agents Phase 1, Phase 2
13 Adrenergic Agonists Phase 1, Phase 2
14 Hormones Phase 1, Phase 2
15 Autonomic Agents Phase 1, Phase 2
16 Neurotransmitter Agents Phase 1, Phase 2
17 Sympathomimetics Phase 1, Phase 2
18 Antineoplastic Agents, Hormonal Phase 1, Phase 2
19 Hormone Antagonists Phase 1, Phase 2
20 Antiemetics Phase 1, Phase 2
21 Methylprednisolone Acetate Phase 1, Phase 2
22 Adrenergic Agents Phase 1, Phase 2
23 Neuroprotective Agents Phase 1, Phase 2
24 Gastrointestinal Agents Phase 1, Phase 2
25 glucocorticoids Phase 1, Phase 2
26 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
27 Protective Agents Phase 1, Phase 2
28
s 1 (combination) Phase 1
29
tannic acid Approved Not Applicable 1401-55-4
30
Benzocaine Approved, Investigational Not Applicable 94-09-7, 1994-09-7 2337

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Mesenchymal Stem Cells for the Treatment of MS Unknown status NCT00781872 Phase 1, Phase 2
2 Evaluation of Autologous Mesenchymal Stem Cell Transplantation (Effects and Side Effects) in Multiple Sclerosis Completed NCT01377870 Phase 1, Phase 2
3 Safety and Tolerability of ISX (Isoxsuprine HCL) in MS Relapses Recruiting NCT03752307 Phase 1, Phase 2 Isoxsuprine Hydrochloride;Placebo;Corticosteroid
4 A Study to Assess the Relative Bioavailability of Different Formulations of GSK2018682, a Sphingosine-1-phosphate Receptor Subtype 1 Agonist, in Healthy Volunteers. Completed NCT01466322 Phase 1 GSK2018682 CD2 Capsule; GSK2018682 CD3 non-micronised Tablet; GSK2018682 CD3 micronised Tablet; GSK2018682 CD3 non-micronised Tablet in fed state
5 A Pilot Study of Intermittent Calorie Restriction in Multiple Sclerosis Completed NCT02647502 Not Applicable

Search NIH Clinical Center for Allergic Encephalomyelitis

Genetic Tests for Allergic Encephalomyelitis

Anatomical Context for Allergic Encephalomyelitis

MalaCards organs/tissues related to Allergic Encephalomyelitis:

42
T Cells, Brain, Spinal Cord, B Cells, Bone, Endothelial, Lymph Node

Publications for Allergic Encephalomyelitis

Articles related to Allergic Encephalomyelitis:

(show top 50) (show all 5004)
# Title Authors Year
1
Passive transfer of allergic encephalomyelitis in rats: a tool for drug mechanism studies and detecting late-acting immunosuppressants. ( 30778876 )
2019
2
Repetitive intrathecal injection of human NMO-IgG with complement exacerbates disease severity with NMO pathology in experimental allergic encephalomyelitis mice. ( 30825702 )
2019
3
Platelet Depletion is Effective in Ameliorating Anxiety-Like Behavior and Reducing the Pro-Inflammatory Environment in the Hippocampus in Murine Experimental Autoimmune Encephalomyelitis. ( 30717130 )
2019
4
Novel insights into the mechanisms underlying depression-associated experimental autoimmune encephalomyelitis. ( 30849414 )
2019
5
γδ T lymphocytes in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis. ( 30831520 )
2019
6
The contribution of astrocytes to the neuroinflammatory response in multiple sclerosis and experimental autoimmune encephalomyelitis. ( 30847559 )
2019
7
Characterization of leptomeningeal inflammation in rodent experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis. ( 30684521 )
2019
8
Reduced expression of the ferroptosis inhibitor glutathione peroxidase-4 in multiple sclerosis and experimental autoimmune encephalomyelitis. ( 30289974 )
2019
9
Regulatory T Cells and Their Derived Cytokine, Interleukin-35, Reduce Pain in Experimental Autoimmune Encephalomyelitis. ( 30651334 )
2019
10
Beneficial effects of Thymus vulgaris extract in experimental autoimmune encephalomyelitis: Clinical, histological and cytokine alterations. ( 30551467 )
2019
11
Enriched environment regulates thymocyte development and alleviates experimental autoimmune encephalomyelitis in mice. ( 30287389 )
2019
12
Astragaloside IV regulates differentiation and induces apoptosis of activated CD4+ T cells in the pathogenesis of experimental autoimmune encephalomyelitis. ( 30385269 )
2019
13
Bacoside-A inhibits inflammatory cytokines and chemokine in experimental autoimmune encephalomyelitis. ( 30551384 )
2019
14
Immune response in the relapsing-remitting experimental autoimmune encephalomyelitis in mice: The role of the NF-κB signaling pathway. ( 30553438 )
2019
15
Tocopherol Emulsions as Functional Autoantigen Delivery Vehicles Evoke Therapeutic Efficacy in Experimental Autoimmune Encephalomyelitis. ( 30615457 )
2019
16
Peripheral viral challenge exacerbates experimental autoimmune encephalomyelitis. ( 30637619 )
2019
17
Sex differences in central nervous system plasticity and pain in experimental autoimmune encephalomyelitis. ( 30649100 )
2019
18
Neuron-specific PERK inactivation exacerbates neurodegeneration during experimental autoimmune encephalomyelitis. ( 30674717 )
2019
19
Absence of endothelial α5β1 integrin triggers early onset of experimental autoimmune encephalomyelitis due to reduced vascular remodeling and compromised vascular integrity. ( 30678721 )
2019
20
Akt-1 and Akt-2 Differentially Regulate the Development of Experimental Autoimmune Encephalomyelitis by Controlling Proliferation of Thymus-Derived Regulatory T Cells. ( 30692211 )
2019
21
Therapeutic Potential of Conditioned Medium Derived from Oligodendrocytes Cultured in a Self-Assembling Peptide Nanoscaffold in Experimental Autoimmune Encephalomyelitis. ( 30703369 )
2019
22
Microglia pre-activation and neurodegeneration precipitate neuroinflammation without exacerbating tissue injury in experimental autoimmune encephalomyelitis. ( 30704526 )
2019
23
MiR-146a promotes oligodendrocyte progenitor cell differentiation and enhances remyelination in a model of experimental autoimmune encephalomyelitis. ( 30707940 )
2019
24
p38MAPK/SGK1 signaling regulates macrophage polarization in experimental autoimmune encephalomyelitis. ( 30716717 )
2019
25
P-glycoprotein Inhibitor Tariquidar Potentiates Efficacy of Astragaloside IV in Experimental Autoimmune Encephalomyelitis Mice. ( 30717494 )
2019
26
Quantitative proteome analysis of brain sub-regions and spinal cord from experimental autoimmune encephalomyelitis mice by TMT-based mass spectrometry. ( 30724464 )
2019
27
Adjuvant and antigenic properties of Mycobacterium avium subsp. paratuberculosis on experimental autoimmune encephalomyelitis. ( 30738572 )
2019
28
Docosahexaenoic acid (22:6n-3) Ameliorated the Onset and Severity of Experimental Autoimmune Encephalomyelitis in Mice. ( 30762234 )
2019
29
Frontline Science: Induction of experimental autoimmune encephalomyelitis mobilizes Th17-promoting myeloid derived suppressor cells to the lung. ( 30762897 )
2019
30
Localization of near-infrared labeled antibodies to the central nervous system in experimental autoimmune encephalomyelitis. ( 30768649 )
2019
31
Nasal delivery of Fasudil-modified immune cells exhibits therapeutic potential in experimental autoimmune encephalomyelitis. ( 30779332 )
2019
32
Celastrol suppresses experimental autoimmune encephalomyelitis via MAPK/SGK1-regulated mediators of autoimmune pathology. ( 30820608 )
2019
33
Amlexanox attenuates experimental autoimmune encephalomyelitis by inhibiting dendritic cell maturation and reprogramming effector and regulatory T cell responses. ( 30823934 )
2019
34
Axonal damage in spinal cord is associated with gray matter atrophy in sensorimotor cortex in experimental autoimmune encephalomyelitis. ( 30843756 )
2019
35
SFX-01 reduces residual disability after experimental autoimmune encephalomyelitis. ( 30851639 )
2019
36
The therapeutic potential of ginkgolide K in experimental autoimmune encephalomyelitis via peripheral immunomodulation. ( 30851709 )
2019
37
Systemic exposure to a single dose of ferucarbotran aggravates neuroinflammation in a murine model of experimental autoimmune encephalomyelitis. ( 30863056 )
2019
38
Systemic administration of orexin A ameliorates established experimental autoimmune encephalomyelitis by diminishing neuroinflammation. ( 30894198 )
2019
39
Lactobacillus reuteri Reduces the Severity of Experimental Autoimmune Encephalomyelitis in Mice by Modulating Gut Microbiota. ( 30899262 )
2019
40
The Genetic Background of Mice Influences the Effects of Cigarette Smoke on Onset and Severity of Experimental Autoimmune Encephalomyelitis. ( 30901861 )
2019
41
Environmental training is beneficial to clinical symptoms and cortical presynaptic defects in mice suffering from experimental autoimmune encephalomyelitis. ( 29402503 )
2019
42
Neuroprotective Effects of Melatonin on Experimental Allergic Encephalomyelitis Mice Via Anti-Oxidative Stress Activity. ( 29450696 )
2018
43
Animal models of multiple sclerosis: Focus on experimental autoimmune encephalomyelitis. ( 29446144 )
2018
44
Correction to: Nebulization of RNS60, a Physically-Modified Saline, Attenuates the Adoptive Transfer of Experimental Allergic Encephalomyelitis in Mice: Implications for Multiple Sclerosis Therapy. ( 29611013 )
2018
45
Glatiramer acetate-specific antibody titres in patients with relapsing a88 remitting multiple sclerosis and in experimental autoimmune encephalomyelitis. ( 29939403 )
2018
46
Differential anxiety-like responses in NOD/ShiLtJ and C57BL/6J mice following experimental autoimmune encephalomyelitis induction and oral gavage. ( 29444620 )
2018
47
Metabolomics approaches in experimental allergic encephalomyelitis. ( 29224959 )
2018
48
A Perspective of Coagulation Dysfunction in Multiple Sclerosis and in Experimental Allergic Encephalomyelitis. ( 30692962 )
2018
49
Amelioration of Experimental autoimmune encephalomyelitis and DSS induced colitis by NTG-A-009 through the inhibition of Th1 and Th17 cells differentiation. ( 29773813 )
2018
50
The Short and Long-Term Effects of Pregnancy on Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis. ( 30486504 )
2018

Variations for Allergic Encephalomyelitis

Expression for Allergic Encephalomyelitis

Search GEO for disease gene expression data for Allergic Encephalomyelitis.

Pathways for Allergic Encephalomyelitis

Pathways related to Allergic Encephalomyelitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.7 CIITA JAK2 NOS2
2 11.58 CIITA JAK2 NOS2
3 11.54 MBP NOS2
4 11.49 JAK2 NOS2
5
Show member pathways
11.46 JAK2 NOS2
6 11.19 JAK2 NOS2
7 11 JAK2 NOS2
8 10.37 CIITA JAK2 NOS2
9 9.86 MBP PLP1

GO Terms for Allergic Encephalomyelitis

Biological processes related to Allergic Encephalomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 central nervous system development GO:0007417 9.4 MBP MOG
2 cellular response to interferon-gamma GO:0071346 9.37 CIITA NOS2
3 interferon-gamma-mediated signaling pathway GO:0060333 9.32 CIITA JAK2
4 myelination GO:0042552 9.26 MBP PLP1
5 substantia nigra development GO:0021762 9.16 MBP PLP1
6 response to antibiotic GO:0046677 8.96 CIITA JAK2
7 axon ensheathment GO:0008366 8.62 MBP PLP1

Molecular functions related to Allergic Encephalomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.13 JAK2 MOG NOS2
2 structural constituent of myelin sheath GO:0019911 8.62 MBP PLP1

Sources for Allergic Encephalomyelitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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