MCID: ALL014
MIFTS: 34

Allergic Encephalomyelitis

Categories: Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Allergic Encephalomyelitis

MalaCards integrated aliases for Allergic Encephalomyelitis:

Name: Allergic Encephalomyelitis 20
Experimental Autoimmune Encephalomyelitis 70

Classifications:



External Ids:

UMLS 70 C0014072

Summaries for Allergic Encephalomyelitis

MalaCards based summary : Allergic Encephalomyelitis, also known as experimental autoimmune encephalomyelitis, is related to myelitis and optic neuritis. An important gene associated with Allergic Encephalomyelitis is MBP (Myelin Basic Protein), and among its related pathways/superpathways are CCR5 Pathway in Macrophages and Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions. Affiliated tissues include t cells, spinal cord and myeloid, and related phenotype is Reduced mammosphere formation.

Wikipedia : 73 Experimental autoimmune encephalomyelitis, sometimes experimental allergic encephalomyelitis (EAE) is an... more...

Related Diseases for Allergic Encephalomyelitis

Diseases related to Allergic Encephalomyelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 165)
# Related Disease Score Top Affiliating Genes
1 myelitis 30.4 MOG MBP
2 optic neuritis 30.4 PLP1 MOG MBP
3 autoimmune disease 30.3 PLP1 MOG MBP CCL5 CCL2
4 acute disseminated encephalomyelitis 30.2 MOG MBP
5 nervous system disease 30.1 MOG MBP CCL2
6 neuromyelitis optica 30.1 MOG MBP
7 guillain-barre syndrome 29.9 MOG MBP
8 spinal cord disease 29.9 MOG MBP
9 proteasome-associated autoinflammatory syndrome 1 29.7 CCL5 CCL3 CCL2
10 central nervous system disease 29.7 PLP1 MOG MBP CCL2
11 demyelinating disease 29.6 PLP1 MOG MBP CCL5 CCL3 CCL2
12 tuberculous meningitis 29.5 CCL3 CCL2
13 tropical spastic paraparesis 29.5 CCL5 CCL3
14 diamond-blackfan anemia 1 29.5 MOG CCL2
15 encephalitis 29.2 MOG CCL5 CCL3 CCL2
16 neuritis 29.1 PLP1 MOG MBP CCL5 CCL3 CCL2
17 autoimmune disease of the nervous system 29.1 MOG MBP CCL5 CCL2
18 multiple sclerosis 28.9 PLP1 MOG MBP CCL5 CCL3 CCL2
19 autoimmune disease of central nervous system 28.7 PLP1 MOG MBP CCL5 CCL2
20 relapsing-remitting multiple sclerosis 28.3 PLP1 MOG MBP CCL5 CCL3 CCL2
21 pertussis 10.7
22 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.5
23 allergic disease 10.5
24 cytokine deficiency 10.4
25 paraplegia 10.3
26 encephalopathy 10.3
27 vaccinia 10.3
28 orchitis 10.2
29 uveitis 10.2
30 lymphopenia 10.2
31 measles 10.2
32 hereditary neuropathies 10.1 PLP1 MBP
33 niemann-pick disease, type a 10.1 PLP1 MBP
34 balo concentric sclerosis 10.1 MOG MBP
35 autoimmune optic neuritis 10.1 MOG MBP
36 internuclear ophthalmoplegia 10.1 MOG MBP
37 rabies 10.1
38 gout 10.1
39 thyroiditis 10.1
40 vasculitis 10.1
41 iridocyclitis 10.1
42 tremor 10.1
43 polyradiculoneuropathy 10.1 MBP CCL5
44 transverse myelitis 10.1 MOG MBP
45 autoimmune disease of peripheral nervous system 10.1 MOG MBP
46 canavan disease 10.1 PLP1 MBP
47 chronic inflammatory demyelinating polyradiculoneuropathy 10.1 MBP CCL5
48 subacute sclerosing panencephalitis 10.1 MOG MBP
49 krabbe disease 10.1 PLP1 MBP
50 meningoencephalitis 10.1 MBP CCL5

Graphical network of the top 20 diseases related to Allergic Encephalomyelitis:



Diseases related to Allergic Encephalomyelitis

Symptoms & Phenotypes for Allergic Encephalomyelitis

GenomeRNAi Phenotypes related to Allergic Encephalomyelitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 8.92 CCL2 CCL3 MOG PLP1

Drugs & Therapeutics for Allergic Encephalomyelitis

Search Clinical Trials , NIH Clinical Center for Allergic Encephalomyelitis

Genetic Tests for Allergic Encephalomyelitis

Anatomical Context for Allergic Encephalomyelitis

MalaCards organs/tissues related to Allergic Encephalomyelitis:

40
T Cells, Spinal Cord, Myeloid, B Cells, Endothelial, Bone Marrow, Brain

Publications for Allergic Encephalomyelitis

Articles related to Allergic Encephalomyelitis:

(show top 50) (show all 11732)
# Title Authors PMID Year
1
Galangin ameliorates experimental autoimmune encephalomyelitis in mice via modulation of cellular immunity. 61
33770444 2021
2
Mesenchymal stem cells instruct a beneficial phenotype in reactive astrocytes. 61
33381863 2021
3
CNS Autoimmune Responses in BCMA-Deficient Mice Provide Insight for the Failure of Atacicept in MS. 61
33649164 2021
4
Regionally diverse astrocyte subtypes and their heterogeneous response to EAE. 61
33332631 2021
5
AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis. 61
33710283 2021
6
Tetramethylpyrazine Protects Blood-Spinal Cord Barrier Integrity by Modulating Microglia Polarization Through Activation of STAT3/SOCS3 and Inhibition of NF-кB Signaling Pathways in Experimental Autoimmune Encephalomyelitis Mice. 61
32424774 2021
7
Dietary factors in experimental autoimmune encephalomyelitis and multiple sclerosis: A comprehensive review. 61
32406797 2021
8
Myeloid-derived suppressor cells support remyelination in a murine model of multiple sclerosis by promoting oligodendrocyte precursor cell survival, proliferation, and differentiation. 61
33217041 2021
9
Helminth Imprinting of Hematopoietic Stem Cells Sustains Anti-Inflammatory Trained Innate Immunity That Attenuates Autoimmune Disease. 61
33579723 2021
10
Cathepsin L regulates pathogenicCD4 T cells in experimental autoimmune encephalomyelitis. 61
33540247 2021
11
Mycobacterium bovis BCG-mediated suppression of Th17 response in mouse experimental autoimmune encephalomyelitis. 61
33541144 2021
12
TRIM28 Expression on Dendritic Cells Prevents Excessive T Cell Priming by Silencing Endogenous Retrovirus. 61
33619215 2021
13
CD11c+CD88+CD317+ myeloid cells are critical mediators of persistent CNS autoimmunity. 61
33785592 2021
14
Change in light-dark cycle affects experimental autoimmune encephalomyelitis. 61
33549942 2021
15
Passive transfer of allergic encephalomyelitis in rats: a tool for drug mechanism studies and detecting late-acting immunosuppressants. 61
30778876 2021
16
Thrombin generation and activity in multiple sclerosis. 61
33411219 2021
17
Novel compounds with dual S1P receptor agonist and histamine H3 receptor antagonist activities act protective in a mouse model of multiple sclerosis. 61
33460688 2021
18
A comprehensive review on the role of chemokines in the pathogenesis of multiple sclerosis. 61
33404937 2021
19
Ruxolitinib attenuates experimental autoimmune encephalomyelitis (EAE) development as animal models of multiple sclerosis (MS). 61
33781828 2021
20
Alleviation of extensive visual pathway dysfunction by a remyelinating drug in a chronic mouse model of multiple sclerosis. 61
33368801 2021
21
Cuprizone and EAE mouse frontal cortex proteomics revealed proteins altered in multiple sclerosis. 61
33785790 2021
22
Serotoninergic system targeting in multiple sclerosis: the prospective for pathogenetic therapy. 61
33756440 2021
23
Direct and indirect effects of microbiota-derived metabolites on neuroinflammation in multiple sclerosis. 61
33775860 2021
24
Activation of FXR by ganoderic acid A promotes remyelination in multiple sclerosis via anti-inflammation and regeneration mechanism. 61
33482151 2021
25
Homotaurine limits the spreading of T cell autoreactivity within the CNS and ameliorates disease in a model of multiple sclerosis. 61
33686135 2021
26
Complete Freund's adjuvant-free experimental autoimmune encephalomyelitis in Dark Agouti rats is a valuable tool for multiple sclerosis studies. 61
33765502 2021
27
The role of immune semaphorins in the pathogenesis of multiple sclerosis: Potential therapeutic targets. 61
33756227 2021
28
Intranasal delivery of interferon-β-loaded nanoparticles induces control of neuroinflammation in a preclinical model of multiple sclerosis: A promising simple, effective, non-invasive, and low-cost therapy. 61
33220325 2021
29
Tissue-restricted control of established central nervous system autoimmunity by TNF receptor 2-expressing Treg cells. 61
33766913 2021
30
Cell type-specific transcriptomics identifies neddylation as a novel therapeutic target in multiple sclerosis. 61
33374005 2021
31
One Brain-All Cells: A Comprehensive Protocol to Isolate All Principal CNS-Resident Cell Types from Brain and Spinal Cord of Adult Healthy and EAE Mice. 61
33804060 2021
32
Remyelination is enhanced by Astragalus polysaccharides through inducing the differentiation of oligodendrocytes from neural stem cells in cuprizone model of demyelination. 61
33794147 2021
33
Prolonging the integrated stress response enhances CNS remyelination in an inflammatory environment. 61
33752802 2021
34
2-(2-Benzofuranyl)-2-Imidazoline Attenuates the Disruption of the Blood-Brain Barrier in EAE via NMDAR. 61
33772673 2021
35
Chromatin Regulator SRG3 Overexpression Protects against LPS/D-GalN-Induced Sepsis by Increasing IL10-Producing Macrophages and Decreasing IFNγ-Producing NK Cells in the Liver. 61
33809795 2021
36
The ameliorative effects of capsidiol isolated from elicited Capsicum annuum on mouse splenocyte immune responses and neuroinflammation. 61
33124100 2021
37
Pericytes regulate vascular immune homeostasis in the CNS. 61
33653955 2021
38
The hedgehog pathway suppresses neuropathogenesis in CD4 T cell-driven inflammation. 61
33723591 2021
39
Monocyte-derived S1P in the lymph node regulates immune responses. 61
33658712 2021
40
Dectin-1 limits autoimmune neuroinflammation and promotes myeloid cell-astrocyte crosstalk via Card9-independent expression of Oncostatin M. 61
33581044 2021
41
Investigating the blood-spinal cord barrier in preclinical models: a systematic review of in vivo imaging techniques. 61
33742118 2021
42
Redox sensor NPGPx restrains ZAP70 activity and modulates T cell homeostasis. 61
33460768 2021
43
The association between EAE development in mice and the production of autoantibodies and abzymes after immunization of mice with different antigens. 61
33560578 2021
44
A mucosal immune response induced by oral administration of heat-killed Mycobacterium avium subsp. paratuberculosis exacerbates EAE. 61
33454553 2021
45
Thyroid hormone and thyromimetics inhibit myelin and axonal degeneration and oligodendrocyte loss in EAE. 61
33422763 2021
46
Selective Depletion of Antigen-Specific Antibodies for the Treatment of Demyelinating Disease. 61
33212299 2021
47
Bilirubin nanomedicine ameliorates the progression of experimental autoimmune encephalomyelitis by modulating dendritic cells. 61
33450316 2021
48
Neuroinflammatory Regulation of Gold Nanoparticles Conjugated to Ethylene Dicysteine Diethyl Ester in Experimental Autoimmune Encephalomyelitis. 61
33586954 2021
49
A Functionally Distinct CXCR3+/IFN-γ+/IL-10+ Subset Defines Disease-Suppressive Myelin-Specific CD8 T Cells. 61
33558376 2021
50
Flavonoids, the compounds with anti-inflammatory and immunomodulatory properties, as promising tools in multiple sclerosis (MS) therapy: A systematic review of preclinical evidence. 61
33770729 2021

Variations for Allergic Encephalomyelitis

Expression for Allergic Encephalomyelitis

Search GEO for disease gene expression data for Allergic Encephalomyelitis.

Pathways for Allergic Encephalomyelitis

Pathways related to Allergic Encephalomyelitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.37 CCL5 CCL3 CCL2
2
Show member pathways
11.88 CCL5 CCL3 CCL2
3 11.3 CCL5 CCL3 CCL2
4 10.93 CCL5 CCL3 CCL2
5 10.53 CCL3 CCL2
6 10.49 CCL5 CCL3 CCL2
7 10.48 CCL5 CCL3 CCL2
8 10.16 PLP1 MBP

GO Terms for Allergic Encephalomyelitis

Cellular components related to Allergic Encephalomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 myelin sheath GO:0043209 8.62 PLP1 MBP

Biological processes related to Allergic Encephalomyelitis according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.88 MBP CCL5 CCL3 CCL2
2 inflammatory response GO:0006954 9.86 PLP1 CCL5 CCL3 CCL2
3 positive regulation of GTPase activity GO:0043547 9.82 CCL5 CCL3 CCL2
4 cytokine-mediated signaling pathway GO:0019221 9.81 CCL5 CCL3 CCL2
5 positive regulation of cell migration GO:0030335 9.8 PLP1 CCL5 CCL3
6 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.79 CCL5 CCL3 CCL2
7 chemotaxis GO:0006935 9.78 CCL5 CCL3 CCL2
8 cellular response to tumor necrosis factor GO:0071356 9.77 CCL5 CCL3 CCL2
9 cellular response to interferon-gamma GO:0071346 9.74 CCL5 CCL3 CCL2
10 response to toxic substance GO:0009636 9.72 MBP CCL5 CCL3
11 MAPK cascade GO:0000165 9.71 MBP CCL5 CCL3 CCL2
12 cell chemotaxis GO:0060326 9.7 CCL5 CCL3 CCL2
13 cellular response to interleukin-1 GO:0071347 9.69 CCL5 CCL3 CCL2
14 neutrophil chemotaxis GO:0030593 9.67 CCL5 CCL3 CCL2
15 myelination GO:0042552 9.65 PLP1 MBP
16 positive chemotaxis GO:0050918 9.65 CCL5 CCL3
17 substantia nigra development GO:0021762 9.65 PLP1 MBP
18 cellular response to fibroblast growth factor stimulus GO:0044344 9.63 CCL5 CCL2
19 chemokine-mediated signaling pathway GO:0070098 9.63 CCL5 CCL3 CCL2
20 positive regulation of calcium ion transport GO:0051928 9.62 CCL5 CCL3
21 positive regulation of calcium ion import GO:0090280 9.61 CCL3 CCL2
22 cellular response to organic cyclic compound GO:0071407 9.61 CCL5 CCL3 CCL2
23 negative regulation by host of viral transcription GO:0043922 9.6 CCL5 CCL3
24 axon ensheathment GO:0008366 9.58 PLP1 MBP
25 positive regulation of natural killer cell chemotaxis GO:2000503 9.54 CCL5 CCL3
26 monocyte chemotaxis GO:0002548 9.54 CCL5 CCL3 CCL2
27 protein kinase B signaling GO:0043491 9.5 CCL5 CCL3 CCL2
28 astrocyte cell migration GO:0043615 9.48 CCL3 CCL2
29 lymphocyte chemotaxis GO:0048247 9.43 CCL5 CCL3 CCL2
30 lipopolysaccharide-mediated signaling pathway GO:0031663 9.33 CCL5 CCL3 CCL2
31 eosinophil chemotaxis GO:0048245 9.13 CCL5 CCL3 CCL2
32 macrophage chemotaxis GO:0048246 8.8 CCL5 CCL3 CCL2

Molecular functions related to Allergic Encephalomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase activity GO:0004672 9.63 CCL5 CCL3 CCL2
2 cytokine activity GO:0005125 9.58 CCL5 CCL3 CCL2
3 chemoattractant activity GO:0042056 9.43 CCL5 CCL3
4 structural constituent of myelin sheath GO:0019911 9.37 PLP1 MBP
5 CCR5 chemokine receptor binding GO:0031730 9.32 CCL5 CCL3
6 phospholipase activator activity GO:0016004 9.26 CCL5 CCL3
7 CCR1 chemokine receptor binding GO:0031726 9.16 CCL5 CCL3
8 chemokine activity GO:0008009 9.13 CCL5 CCL3 CCL2
9 CCR chemokine receptor binding GO:0048020 8.8 CCL5 CCL3 CCL2

Sources for Allergic Encephalomyelitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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