MCID: ALL026
MIFTS: 67

Allergic Hypersensitivity Disease

Categories: Immune diseases

Aliases & Classifications for Allergic Hypersensitivity Disease

MalaCards integrated aliases for Allergic Hypersensitivity Disease:

Name: Allergic Hypersensitivity Disease 12 15
Hypersensitivity 12 76 44 15 73
Allergy 12 55 6 43
Allergic Disposition 73
Allergic Condition 73
Allergic Reaction 73
Allergic Disease 12
Allergies 63

Classifications:



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Disease Ontology 12 DOID:1205
ICD10 33 T78.40 T78.4
MeSH 44 D006967
NCIt 50 C3114
SNOMED-CT 68 21957007 91232002

Summaries for Allergic Hypersensitivity Disease

MedlinePlus : 43 An allergy is a reaction by your immune system to something that does not bother most other people. People who have allergies often are sensitive to more than one thing. Substances that often cause reactions are Pollen Dust mites Mold spores Pet dander Food Insect stings Medicines Normally, your immune system fights germs. It is your body's defense system. In most allergic reactions, however, it is responding to a false alarm. Genes and the environment probably both play a role. Allergies can cause a variety of symptoms such as a runny nose, sneezing, itching, rashes, swelling, or asthma. Allergies can range from minor to severe. Anaphylaxis is a severe reaction that can be life-threatening. Doctors use skin and blood tests to diagnose allergies. Treatments include medicines, allergy shots, and avoiding the substances that cause the reactions. NIH: National Institute of Allergy and Infectious Diseases

MalaCards based summary : Allergic Hypersensitivity Disease, also known as hypersensitivity, is related to cow milk allergy and cephalosporin allergy, and has symptoms including nausea and vomiting, abdominal pain and pruritus. An important gene associated with Allergic Hypersensitivity Disease is IL5 (Interleukin 5), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include testes, skin and breast, and related phenotypes are hematopoietic system and digestive/alimentary

Disease Ontology : 12 An immune system disease that is an exaggerated immune response to allergens, such as insect venom, dust mites, pollen, pet dander, drugs or some foods.

PubMed Health : 63 About allergies: Allergies arise if the body's immune system overreacts to foreign substances (allergens) that are usually harmless in most people, such as pollen or certain foods. The symptoms can vary a lot. In some cases they are quite mild, but they can also be a real nuisance and have a considerable impact in everyday life. Severe allergic reactions may be life-threatening.There are various treatment options for allergies. Some things that trigger allergies (allergens) are easy to avoid, whereas others aren't. Common allergens include the following:

Wikipedia : 76 Hypersensitivity (also called hypersensitivity reaction or intolerance) refers to undesirable reactions... more...

Related Diseases for Allergic Hypersensitivity Disease

Diseases related to Allergic Hypersensitivity Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1261)
# Related Disease Score Top Affiliating Genes
1 cow milk allergy 33.8 IL10 IL5 RNASE3
2 cephalosporin allergy 33.8 IFNG IL10 IL5
3 beta-lactam allergy 33.8 IL10 IL13 IL4
4 apple allergy 33.7 CCL17 IL10 IL13 IL4 IL5
5 respiratory allergy 33.3 CCL11 IGHE IL10 IL13 IL4 IL5
6 allergic contact dermatitis 32.5 CCL17 IFNG IL10 IL4 IL5
7 esophagitis, eosinophilic, 1 32.1 CCL11 IL13 IL5
8 blepharoconjunctivitis 32.1 CCL11 IL4 RNASE3
9 giant papillary conjunctivitis 32.1 CCL11 IL4 RNASE3
10 conjunctivitis 32.1 CCL11 HRH1 IFNG IL13 IL4 IL5
11 orofacial granulomatosis 32.0 CCL5 CCR3 IFNG IL10 IL4
12 vernal keratoconjunctivitis 31.9 CCL11 CCL5 IL13 IL4 IL5 RNASE3
13 allergic conjunctivitis 31.9 CCL11 HRH1 IFNG IL13 IL4 IL5
14 immune system disease 31.7 IFNG IL10 IL13 IL4 IL5 TLR9
15 autoimmune disease of eyes, ear, nose and throat 31.6 CCL5 IL10 TLR9
16 mycobacterium tuberculosis 1 31.5 IFNG IL10 IL4 TLR9
17 autoimmune disease of musculoskeletal system 31.5 IL10 IL4 TLR9
18 sarcoidosis 1 31.5 CCL17 IFNG IL13 IL9
19 autoimmune disease of central nervous system 31.5 CCL5 IFNG IL10 IL4 TLR9
20 contact dermatitis 30.9 CCL17 IFNG IL10 IL4 IL5
21 eosinophilic gastroenteritis 30.6 CCL11 IL5 RNASE3
22 autoimmune disease 30.6 IFNG IL10 IL4 IL5 TLR9
23 colitis 30.6 IFNG IL10 IL4 TLR9
24 gastroenteritis 30.5 CCL11 IL10 IL4 IL5 RNASE3
25 food allergy 30.5 CSN1S1 IFNG IL10 IL13 IL4 IL5
26 dermatitis 30.4 CCL11 CCL17 IFNG IGHE IL13 IL4
27 meningitis 30.3 IFNG IL10 TLR9
28 allergic bronchopulmonary aspergillosis 30.3 CCL17 IL4 IL5
29 mycosis fungoides 30.3 CCL17 CCR3 IL5
30 pollen allergy 30.2 IL13 IL5 RNASE3
31 common cold 30.2 CCL11 CCL5 IL13 IL5 RNASE3 TLR9
32 tetanus 30.2 IFNG IL10 IL13 IL4 IL5
33 gastrointestinal system disease 30.2 CCL11 IFNG IL10 TLR9
34 pulmonary fibrosis, idiopathic 30.2 CCL17 CCL5 IFNG IL13 TLR9
35 paracoccidioidomycosis 30.2 IFNG IL10 IL4 IL5
36 lichen planus 30.2 IFNG IL4 TLR9
37 yellow fever 30.2 CCL5 IL4 IL5 TLR9
38 ige responsiveness, atopic 30.2 IFNG IGHE IL10 IL13 IL4 IL5
39 aspergillosis 30.2 CCL17 IFNG IL10 IL4 IL5 TLR9
40 pneumonia 30.1 CCL11 CCL5 IL10 IL13 IL5 TLR9
41 egg allergy 30.1 IGHE IL4 IL5
42 bronchitis 30.1 CCL11 CCR3 IL5 RNASE3
43 lung disease 30.1 CCL5 IL10 IL13 IL5 RNASE3 TLR9
44 hypereosinophilic syndrome 30.0 CCL11 CCL17 IGES IGHE IL13 IL4
45 peanut allergy 30.0 IFNG IGHE IL10 IL13
46 demyelinating disease 30.0 CCL5 IFNG IL10
47 chlamydia 30.0 IFNG IL10 IL4
48 sporotrichosis 30.0 IFNG IL10
49 multiple sclerosis 30.0 CCL5 IFNG IL10 IL4 IL5 TLR9
50 scabies 30.0 CCL11 IL10 KITLG

Graphical network of the top 20 diseases related to Allergic Hypersensitivity Disease:



Diseases related to Allergic Hypersensitivity Disease

Symptoms & Phenotypes for Allergic Hypersensitivity Disease

UMLS symptoms related to Allergic Hypersensitivity Disease:


nausea and vomiting, abdominal pain, pruritus, tinnitus, syncope, stridor, snoring, coughing, fever of unknown origin, sore throat, exanthema, vertigo/dizziness, equilibration disorder, signs and symptoms of ill-defined conditions, (non-specific) malaise and fatigue, injection site hypersensitivity

MGI Mouse Phenotypes related to Allergic Hypersensitivity Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.13 CCL11 CCL17 CCL5 CCR3 FCER2 HRH1
2 digestive/alimentary MP:0005381 9.97 FCER2 IFNG IL10 IL13 IL4 IL5
3 homeostasis/metabolism MP:0005376 9.93 CCR3 FCER2 HRH1 HRH4 IFNG IL10
4 immune system MP:0005387 9.83 CCL11 CCL17 CCL5 CCR3 FCER2 HRH1
5 respiratory system MP:0005388 9.17 CCL11 CCR3 IFNG IL10 IL13 IL4

Drugs & Therapeutics for Allergic Hypersensitivity Disease

PubMedHealth treatment related to Allergic Hypersensitivity Disease: 63

The best way to prevent allergic reactions is to avoid contact with the triggers (allergens). How well this works will mainly depend on the type of trigger. It’s often quite easy to avoid contact with things like certain foods or chemical substances. It’s almost impossible to avoid pollen, though. But pollen calendars and forecasts, for instance on the internet, can give you an idea of the pollen count in certain regions. People with dust mite allergies can somewhat lower their exposure to dust mites in their home by taking precautions such as using mite-proof bedding and removing "dust traps."The symptoms of many allergies can be treated with medication. Antihistamines and steroids are often used for this purpose. These medications are available in various forms, including tablets, nasal sprays and injections. They are mainly used in the treatment of allergic rhinitis (in the nose) and allergic conjunctivitis (in the eyes). Allergic reactions affecting the skin are also treated using steroid ointments or creams.A treatment known as allergen-specific immunotherapy (“desensitization”) can help reduce sensitivity to some allergens in the long term. Like with vaccines, this treatment approach involves exposing people to small amounts of the allergen. Here it is done at regular intervals by either injecting the allergen into your skin or placing it under your tongue. It takes about three to five years to complete allergen-specific immunotherapy. This approach is mainly used for the treatment of allergies to pollen (hay fever), dust mites and insect venom.There is currently no evidence that herbal or homeopathic products can help in the treatment of allergies. This is also true for acupuncture.

Search Clinical Trials , NIH Clinical Center for Allergic Hypersensitivity Disease

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: hypersensitivity

Genetic Tests for Allergic Hypersensitivity Disease

Anatomical Context for Allergic Hypersensitivity Disease

MalaCards organs/tissues related to Allergic Hypersensitivity Disease:

41
Testes, Skin, Breast, Lung, T Cells, Bone, Prostate

Publications for Allergic Hypersensitivity Disease

Articles related to Allergic Hypersensitivity Disease:

(show top 50) (show all 1022)
# Title Authors Year
1
Parental concerns of allergy or hypersensitivity and the infant's diet. ( 30534403 )
2019
2
Aluminum Ingestion Promotes Colorectal Hypersensitivity in Rodents. ( 30534582 )
2019
3
Myocardial hypersensitivity to ischemic injury is not reversed by clonidine or propranolol in a predator-based rat model of posttraumatic stress disorder. ( 30194949 )
2019
4
Inhibitory effects of dietary soy isoflavone and gut microbiota on contact hypersensitivity in mice. ( 30309552 )
2019
5
Diazepam as attenuator of pain induced by dentin hypersensitivity in rats exposed to stress. ( 30391792 )
2019
6
Hypersensitivity Pneumonitis and Acute Respiratory Distress Syndrome From E-Cigarette Use. ( 29773665 )
2018
7
Allergic contact dermatitis caused by hypersensitivity to gold - description of a clinical case. ( 29611263 )
2018
8
Neural hypersensitivity to pleasant touch in women remitted from anorexia nervosa. ( 30115929 )
2018
9
Risk of Heparin-induced Immediate-type Hypersensitivity during Arteriovenous Fistula Placement. ( 29526971 )
2018
10
Allergen-specific immunoglobulin E in sera of horses affected with insect bite hypersensitivity, severe equine asthma or both conditions. ( 30520523 )
2018
11
Jin Gui Shen Qi Wan, a traditional Chinese medicine, alleviated allergic airway hypersensitivity and inflammatory cell infiltration in a chronic asthma mouse model. ( 30172058 )
2018
12
Higher Tactile Temporal Resolution as a Basis of Hypersensitivity in Individuals with Autism Spectrum Disorder. ( 30019275 )
2018
13
Elevated Levels of Intelectin-1, a Pathogen-binding Lectin, in the BAL Fluid of Patients with Chronic Eosinophilic Pneumonia and Hypersensitivity Pneumonitis. ( 30101907 )
2018
14
Dampness and mold hypersensitivity syndrome and vaccination as risk factors for chronic fatigue syndrome. ( 30408578 )
2018
15
The Protective Effect of Melissa officinalis L. in Visceral Hypersensitivity in Rat Using 2 Models of Acid-induced Colitis and Stress-induced Irritable Bowel Syndrome: A Possible Role of Nitric Oxide Pathway. ( 29879761 )
2018
16
A Case of Right-Sided Ulcerative Colitis with Mesalamine-Induced Hypersensitivity Reactions. ( 29849018 )
2018
17
Hypersensitivity reactions to intravenous antibiotics in cystic fibrosis. ( 29703693 )
2018
18
Use of maropitant for the control of pruritus in non-flea, non-food-induced feline hypersensitivity dermatitis: an open-label uncontrolled pilot study. ( 30427273 )
2018
19
Allergy to Peanuts in Atopic Dermatitis Patients 14 Year or Older and the Association with Food Hypersensitivity, Inhalant Allergens, Asthma Bronchiale and Rhinitis. ( 30078876 )
2018
20
Cannabinoid receptor types 1 and 2 and peroxisome proliferator-activated receptor-α: distribution in the skin of clinically healthy cats and cats with hypersensitivity dermatitis. ( 29920828 )
2018
21
Cytokine Profile and Immunoglobulin E-mediated Serological Food Hypersensitivity in Patients With Irritable Bowel Syndrome With Diarrhea. ( 29739174 )
2018
22
Drug allergy evaluation for betalactam hypersensitivity: Cross-reactivity with cephalosporines, carbapenems and negative predictive value. ( 28577519 )
2018
23
TEMPORARY REMOVAL: Controversies in Drug Allergy: Beta-Lactam Hypersensitivity Testing. ( 30245291 )
2018
24
Successful desensitization to cloxacillin in a patient with sepsis, with infective endocarditis and clinical suspicion of hypersensitivity to penicillins, a case report. ( 30030968 )
2018
25
Delayed-type hypersensitivity to metals in connective tissue diseases and fibromyalgia. ( 29245125 )
2018
26
A Unique Case Report on Hypersensitivity Vasculitis as an Allergic Reaction to the Herpes Zoster Vaccine. ( 30122132 )
2018
27
Hyperacusis in Children: A Preliminary Study on the Effects of Hypersensitivity to Sound on Speech and Language. ( 29993211 )
2018
28
Titanium hypersensitivity causing painful intra-abdominal oedema after staple-fixed inguinal hernia repair. ( 29521457 )
2018
29
Exploring the Potential of RET Kinase Inhibition for Irritable Bowel Syndrome: A Preclinical Investigation in Rodent Models of Colonic Hypersensitivity. ( 30413627 )
2018
30
Electroacupuncture Relieves Visceral Hypersensitivity by Inactivating Protease-Activated Receptor 2 in a Rat Model of Postinfectious Irritable Bowel Syndrome. ( 30420896 )
2018
31
High-resolution computerized tomography changes in diffuse parenchymal lung disease from chronic hypersensitivity pneumonitis related to bird antigen. ( 29697078 )
2018
32
Drug-Induced Hypersensitivity Syndrome: A Clinical, Radiologic, and Histologic Mimic of Lymphoma. ( 30420928 )
2018
33
PEG-L-CHOP treatment is safe and effective in adult extranodal NK/T-cell lymphoma with a low rate of clinical hypersensitivity. ( 30241515 )
2018
34
Low frequency of acetyl salicylic acid hypersensitivity in mastocytosis: The results of a double-blind, placebo-controlled challenge study. ( 29569284 )
2018
35
Syncope and hypotension associated with carotid sinus hypersensitivity in a patient with nasopharyngeal carcinoma: A case report. ( 30212984 )
2018
36
Tumor necrosis factor-α mediated pain hypersensitivity through Ret receptor in resiniferatoxin neuropathy. ( 30173779 )
2018
37
Anti-nerve growth factor therapy attenuates cutaneous hypersensitivity and musculoskeletal discomfort in mice with osteoporosis. ( 29922744 )
2018
38
Impact of carboplatin hypersensitivity and desensitization on patients with recurrent ovarian cancer. ( 30255380 )
2018
39
Latex hypersensitivity to injection devices for biologic therapies in psoriasis patients. ( 30235360 )
2018
40
Psoriasis is an independent predictor of increased risk of allergic reaction during percutaneous coronary interventions. Big data analysis from the Polish National PCI Registry (ORPKI). ( 30155870 )
2018
41
Recurrent Pulmonary Embolism and Hypersensitivity Pneumonitis Secondary to Aspergillus, in a Compost Plant Worker: Case Report and Review of Literature. ( 30027471 )
2018
42
Contact hypersensitivity in rosacea - a report on 143 cases. ( 29524258 )
2018
43
Chemokine (c-c motif) receptor 2 mediates mechanical and cold hypersensitivity in sickle cell disease mice. ( 29697532 )
2018
44
Peripheral inflammation accelerates the onset of mechanical hypersensitivity after spinal cord injury and engages TNFα signaling mechanisms. ( 30520675 )
2018
45
Coexisting mechanical hypersensitivity and anxiety in a rat model of spinal cord injury and the effect of pregabalin, morphine, and midazolam treatment. ( 29913744 )
2018
46
A novel affective-motivational-based Overground System for detecting spinal cord injury-associated thermal and mechanical hypersensitivity in rats. ( 29756383 )
2018
47
Usefulness of basophil activation test for the diagnosis of IgE mediated hypersensitivity to tetanus toxoid vaccine. ( 29162425 )
2018
48
Severe allergic reaction during angioplasty culminating to fatal acute stent thrombosis: An association with Kounis syndrome. ( 30245248 )
2018
49
Acute urticaria: an extremely rare adverse effect of levonorgestrel-releasing intrauterine system as a possible manifestation of progestogen hypersensitivity syndrome. ( 30429715 )
2018
50
Recall Urticaria in Adalimumab Hypersensitivity. ( 29175008 )
2018

Variations for Allergic Hypersensitivity Disease

ClinVar genetic disease variations for Allergic Hypersensitivity Disease:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 SLC9A6 NM_001042537.1(SLC9A6): c.1346C> A (p.Ala449Glu) single nucleotide variant Uncertain significance GRCh37 Chromosome X, 135098913: 135098913
2 SLC9A6 NM_001042537.1(SLC9A6): c.1346C> A (p.Ala449Glu) single nucleotide variant Uncertain significance GRCh38 Chromosome X, 136016754: 136016754
3 GFOD1; MCUR1; NOL7; PHACTR1; RANBP9; RNF182; SIRT5; TBC1D7 GRCh37/hg19 6p24.1-23(chr6: 12536624-13968949) copy number gain Uncertain significance GRCh37 Chromosome 6, 12536624: 13968949

Expression for Allergic Hypersensitivity Disease

Search GEO for disease gene expression data for Allergic Hypersensitivity Disease.

Pathways for Allergic Hypersensitivity Disease

Pathways related to Allergic Hypersensitivity Disease according to GeneCards Suite gene sharing:

(show all 42)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.03 CCL11 CCL5 FCER2 IFNG IGHE IL10
2
Show member pathways
13.86 CCL11 CCL17 CCL5 CCR3 HRH4 IL10
3
Show member pathways
13.71 CCL11 CCL17 CCL5 CCR3 FCER2 HRH4
4
Show member pathways
13.55 CCL11 CCL17 CCL5 IFNG IL10 IL13
5
Show member pathways
13.42 CCL11 CCL5 FCER2 IFNG IGHE IL10
6
Show member pathways
13.42 CCL11 CCL17 CCL5 CCR3 HRH4 IL10
7
Show member pathways
13.33 CCL11 CCL17 CCL5 CCR3 HRH4 IL10
8
Show member pathways
12.94 CCL11 IFNG IL10 IL13 IL4 IL5
9
Show member pathways
12.84 CCL11 CCL17 CCL5 CCR3 HRH4
10 12.8 IFNG IL13 IL4 IL5 KITLG
11
Show member pathways
12.77 CCL5 IFNG IL13 IL4 TLR9
12 12.63 CCL5 IFNG IL10 IL4 KITLG TLR9
13
Show member pathways
12.6 IFNG IL10 IL13 IL4 IL5
14
Show member pathways
12.45 IFNG IL10 IL4 IL5 IL9
15
Show member pathways
12.45 IFNG IL10 IL13 IL4 IL5 IL9
16
Show member pathways
12.42 CCL11 FCER2 HRH1 IGHE IL4
17
Show member pathways
12.41 CCL11 CCL17 IFNG IL13 IL4 IL5
18
Show member pathways
12.34 IFNG IL10 IL13 IL4 IL5 IL9
19
Show member pathways
12.19 CCL11 CCL17 CCL5 CCR3 TLR9
20
Show member pathways
12.18 CCL11 IFNG IL4 TLR9
21 12.09 CCR3 IFNG IL10 IL4 IL5 KITLG
22 12.07 CCL11 FCER2 IGHE IL10 IL13 IL4
23
Show member pathways
12.01 CCL11 CCL17 CCL5 CCR3
24
Show member pathways
11.97 CCL11 CCL17 CCL5 IFNG IL10 IL13
25 11.92 FCER2 IL4 IL5 KITLG
26 11.84 IFNG IL13 IL4 IL5
27 11.84 IFNG IL10 IL13 IL4 IL5 IL9
28
Show member pathways
11.73 IFNG IL4 IL5
29 11.72 IFNG IL10 TLR9
30 11.72 CCL11 CCL17 CCL5 IFNG IL10 IL13
31 11.68 CCL11 CCL5 CCR3 IL13 IL4 IL5
32 11.65 CCL5 FCER2 IL10 IL13 IL4
33 11.54 IFNG IL10 TLR9
34 11.38 IFNG IL10 TLR9
35 11.38 IFNG IL13 IL4 IL5 IL9
36 11.35 IFNG IL4 IL5
37 11.3 CCL11 CCL17 FCER2 IGHE IL10 IL4
38 11.29 IFNG IL10 IL13 IL4 IL5
39 11.2 CCL11 CCL17 CCL5 IL10 IL13 IL4
40 11.07 CCL11 CCL17 CCL5 IL10 IL13 IL4
41 11.05 IFNG IL10 IL13 IL4 IL5 IL9
42 10.89 CCL11 CCL17 IFNG IL10 IL13 IL4

GO Terms for Allergic Hypersensitivity Disease

Cellular components related to Allergic Hypersensitivity Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.77 CCL11 CCL17 CCL5 CSN1S1 IFNG IL10
2 extracellular region GO:0005576 9.5 CCL11 CCL17 CCL5 CSN1S1 FCER2 IFNG

Biological processes related to Allergic Hypersensitivity Disease according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.92 IGHE IL10 RNASE3 TLR9
2 chemotaxis GO:0006935 9.87 CCL11 CCL17 CCL5 CCR3
3 cytokine-mediated signaling pathway GO:0019221 9.86 CCL11 CCL5 FCER2 IGHE IL10 IL13
4 regulation of signaling receptor activity GO:0010469 9.85 CCL11 CCL17 CCL5 IFNG IL10 IL13
5 cellular calcium ion homeostasis GO:0006874 9.81 CCL11 CCL5 TPT1
6 cellular response to interferon-gamma GO:0071346 9.81 CCL11 CCL17 CCL5
7 neutrophil chemotaxis GO:0030593 9.79 CCL11 CCL17 CCL5
8 cellular response to interleukin-1 GO:0071347 9.78 CCL11 CCL17 CCL5
9 positive regulation of endothelial cell proliferation GO:0001938 9.77 CCL11 CCR3 IL10
10 response to virus GO:0009615 9.76 CCL11 CCL5 IFNG TPT1
11 monocyte chemotaxis GO:0002548 9.73 CCL11 CCL17 CCL5
12 chemokine-mediated signaling pathway GO:0070098 9.71 CCL11 CCL17 CCL5 CCR3
13 inflammatory response GO:0006954 9.7 CCL11 CCL17 CCL5 CCR3 HRH1 HRH4
14 negative regulation of endothelial cell apoptotic process GO:2000352 9.69 IL10 IL13 IL4
15 lymphocyte chemotaxis GO:0048247 9.67 CCL11 CCL17 CCL5
16 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.67 CCL5 IFNG IL13 IL4
17 positive regulation of macrophage activation GO:0043032 9.64 IL10 IL13
18 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.63 FCER2 TLR9
19 response to molecule of bacterial origin GO:0002237 9.62 IL10 TLR9
20 positive regulation of B cell proliferation GO:0030890 9.62 IL13 IL4 IL5 TLR9
21 eosinophil chemotaxis GO:0048245 9.61 CCL11 CCL5 HRH1
22 positive regulation of immunoglobulin production GO:0002639 9.59 IL13 TLR9
23 negative regulation of interleukin-8 production GO:0032717 9.58 IL10 TLR9
24 positive regulation of MHC class II biosynthetic process GO:0045348 9.58 IL10 IL4
25 positive regulation of killing of cells of other organism GO:0051712 9.55 FCER2 IFNG
26 regulation of isotype switching GO:0045191 9.54 IL10 IL4
27 type 2 immune response GO:0042092 9.52 IL10 IL4
28 negative regulation of complement-dependent cytotoxicity GO:1903660 9.48 IL13 IL4
29 immune response GO:0006955 9.4 CCL11 CCL17 CCL5 CCR3 IFNG IGHE

Molecular functions related to Allergic Hypersensitivity Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.54 CCL11 CCL17 CCL5
2 CCR chemokine receptor binding GO:0048020 9.5 CCL11 CCL17 CCL5
3 cytokine receptor binding GO:0005126 9.43 IL13 IL4 IL9
4 histamine receptor activity GO:0004969 9.4 HRH1 HRH4
5 growth factor activity GO:0008083 9.35 IL10 IL4 IL5 IL9 KITLG
6 cytokine activity GO:0005125 9.32 CCL11 CCL17 CCL5 IFNG IL10 IL13
7 CCR4 chemokine receptor binding GO:0031729 9.16 CCL17 CCL5

Sources for Allergic Hypersensitivity Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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