Aliases & Classifications for Allergic Hypersensitivity Disease

MalaCards integrated aliases for Allergic Hypersensitivity Disease:

Name: Allergic Hypersensitivity Disease 12 15
Hypersensitivity 12 76 44 73
Allergy 12 55 6 43
Allergic Disposition 73
Allergic Condition 73
Allergic Reaction 73
Allergic Disease 12
Allergies 63


Summaries for Allergic Hypersensitivity Disease

MedlinePlus : 43 An allergy is a reaction by your immune system to something that does not bother most other people. People who have allergies often are sensitive to more than one thing. Substances that often cause reactions are Pollen Dust mites Mold spores Pet dander Food Insect stings Medicines Normally, your immune system fights germs. It is your body's defense system. In most allergic reactions, however, it is responding to a false alarm. Genes and the environment probably both play a role. Allergies can cause a variety of symptoms such as a runny nose, sneezing, itching, rashes, swelling, or asthma. Allergies can range from minor to severe. Anaphylaxis is a severe reaction that can be life-threatening. Doctors use skin and blood tests to diagnose allergies. Treatments include medicines, allergy shots, and avoiding the substances that cause the reactions. NIH: National Institute of Allergy and Infectious Diseases

MalaCards based summary : Allergic Hypersensitivity Disease, also known as hypersensitivity, is related to extrinsic allergic alveolitis and hypersensitivity reaction type iv disease, and has symptoms including coughing, exanthema and pruritus. An important gene associated with Allergic Hypersensitivity Disease is IL5 (Interleukin 5), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. Affiliated tissues include skin, testes and tongue, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 An immune system disease that is an exaggerated immune response to allergens, such as insect venom, dust mites, pollen, pet dander, drugs or some foods.

PubMed Health : 63 About allergies: Allergies arise if the body's immune system overreacts to foreign substances (allergens) that are usually harmless in most people, such as pollen or certain foods. The symptoms can vary a lot. In some cases they are quite mild, but they can also be a real nuisance and have a considerable impact in everyday life. Severe allergic reactions may be life-threatening.There are various treatment options for allergies. Some things that trigger allergies (allergens) are easy to avoid, whereas others aren't. Common allergens include the following:

Wikipedia : 76 Hypersensitivity (also called hypersensitivity reaction or intolerance) refers to undesirable reactions... more...

Related Diseases for Allergic Hypersensitivity Disease

Diseases related to Allergic Hypersensitivity Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 230)
# Related Disease Score Top Affiliating Genes
1 extrinsic allergic alveolitis 34.2 CD79A FCER2 IL10
2 hypersensitivity reaction type iv disease 34.1 CD79A IFNG TLR9
3 hypersensitivity reaction disease 33.0 CD79A IFNG IL10 IL13 IL4 IL5
4 esophagitis, eosinophilic, 1 32.5 CCL11 IL13 IL5 STAT6 TSLP
5 ige responsiveness, atopic 30.8 CSN1S1 FCER2 IFNG IL10 IL13 IL4
6 peanut allergy 30.7 IFNG IL10 IL13
7 intrinsic asthma 30.6 FCER2 IL4 IL5 RNASE3
8 esophagitis 30.5 CCL11 IL13 IL5 TSLP
9 uveitis 30.4 IFNG IL10 IL4
10 myasthenia gravis 30.4 IFNG IL10 IL4
11 dermatitis 30.4 CCL11 IFNG IL13 IL4 IL5 RNASE3
12 otitis media 30.4 CCL11 CD79A IL10 RNASE3
13 urticaria 30.4 FCER2 MS4A2 RNASE3
14 strongyloidiasis 30.2 CCL11 CD79A IFNG IL13 IL5
15 common variable immunodeficiency 30.2 CD79A IFNG IL10 IL4 TLR9
16 rhinitis 29.4 CCL11 EPX IL13 IL4 IL4R IL5
17 allergic rhinitis 28.7 CCL11 EPX IFNG IL10 IL13 IL4
18 food allergy 28.5 CSN1S1 EPX IFNG IL10 IL13 IL4
19 allergic asthma 28.2 CCL11 EPX IFNG IL10 IL13 IL4
20 asthma 27.7 CCL11 CD79A EPX FCER2 IFNG IL10
21 dermatitis, atopic 27.5 CCL11 CSN1S1 EPX FCER2 IFNG IL10
22 hypersensitivity vasculitis 12.4
23 hypersensitivity pneumonitis, familial 12.3
24 hypersensitivity reaction type iii disease 11.9
25 asparagus, specific smell hypersensitivity 11.8
26 insect stings, hypersensitivity to 11.8
27 severe cutaneous adverse reaction 11.7
28 bird fancier's lung 11.7
29 mycoplasmal pneumonia 11.1 IFNG IL4
30 tropical endomyocardial fibrosis 11.1 IL10 IL4
31 eosinophilic fasciitis 11.1 IFNG IL5
32 cough variant asthma 11.1 IL4 IL5 RNASE3
33 paragonimiasis 11.0 IL13 IL5 RNASE3
34 chronic tic disorder 11.0 IL13 IL4 IL5
35 persistent polyclonal b-cell lymphocytosis 11.0 FCER2 IL4
36 blepharoconjunctivitis 11.0 CCL11 IL4 RNASE3
37 loeffler endocarditis 11.0 IL5 RNASE3
38 giant papillary conjunctivitis 11.0 CCL11 IL4 RNASE3
39 hyperlucent lung 11.0 IFNG IL10 IL4
40 ascaris lumbricoides infection 11.0 IL13 IL5 TSLP
41 chronic eosinophilic pneumonia 11.0 CCL11 IL5 RNASE3
42 pemphigoid gestationis 11.0 CCL11 IL5
43 angioimmunoblastic lymphadenopathy with dysproteinemia 11.0 IL13 IL5
44 chronic interstitial cystitis 11.0 CD79A RNASE3
45 baylisascariasis 11.0 IFNG IL10 IL4
46 genital herpes 11.0 IL10 IL4 TLR9
47 night blindness, congenital stationary, type 1a 11.0 CCL11 IL13 IL5
48 multicentric castleman disease 11.0 IFNG IL10 IL5
49 buruli ulcer 11.0 IFNG IL10 IL4
50 neuroschistosomiasis 11.0 CD79A IFNG

Graphical network of the top 20 diseases related to Allergic Hypersensitivity Disease:

Diseases related to Allergic Hypersensitivity Disease

Symptoms & Phenotypes for Allergic Hypersensitivity Disease

UMLS symptoms related to Allergic Hypersensitivity Disease:

coughing, exanthema, pruritus, snoring, stridor, tinnitus, injection site hypersensitivity, sore throat, vertigo/dizziness, equilibration disorder, abdominal pain, fever of unknown origin, (non-specific) malaise and fatigue, nausea and vomiting, syncope, signs and symptoms of ill-defined conditions

MGI Mouse Phenotypes related to Allergic Hypersensitivity Disease:

# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.27 TLR9 TSLP IL9 MS4A2 STAT6 IL5
2 immune system MP:0005387 10.19 TSLP IL9 MS4A2 SCP2 STAT6 TLR9
3 digestive/alimentary MP:0005381 10.14 TLR9 TSLP IL9 IL5 IL10 IL13
4 homeostasis/metabolism MP:0005376 10.13 TLR9 TSLP IL5 IL9 SCP2 STAT6
5 integument MP:0010771 9.76 TSLP LALBA STAT6 IL4R IFNG IL10
6 liver/biliary system MP:0005370 9.56 SCP2 STAT6 IL4R IFNG IL5 IL10
7 respiratory system MP:0005388 9.32 TSLP STAT6 IFNG IL5 IL10 CCL11

Drugs & Therapeutics for Allergic Hypersensitivity Disease

PubMedHealth treatment related to Allergic Hypersensitivity Disease: 63

The best way to prevent allergic reactions is to avoid contact with the triggers (allergens). How well this works will mainly depend on the type of trigger. It’s often quite easy to avoid contact with things like certain foods or chemical substances. It’s almost impossible to avoid pollen, though. But pollen calendars and forecasts, for instance on the internet, can give you an idea of the pollen count in certain regions. People with dust mite allergies can somewhat lower their exposure to dust mites in their home by taking precautions such as using mite-proof bedding and removing "dust traps."The symptoms of many allergies can be treated with medication. Antihistamines and steroids are often used for this purpose. These medications are available in various forms, including tablets, nasal sprays and injections. They are mainly used in the treatment of allergic rhinitis (in the nose) and allergic conjunctivitis (in the eyes). Allergic reactions affecting the skin are also treated using steroid ointments or creams.A treatment known as allergen-specific immunotherapy (“desensitization”) can help reduce sensitivity to some allergens in the long term. Like with vaccines, this treatment approach involves exposing people to small amounts of the allergen. Here it is done at regular intervals by either injecting the allergen into your skin or placing it under your tongue. It takes about three to five years to complete allergen-specific immunotherapy. This approach is mainly used for the treatment of allergies to pollen (hay fever), dust mites and insect venom.There is currently no evidence that herbal or homeopathic products can help in the treatment of allergies. This is also true for acupuncture.

Search Clinical Trials , NIH Clinical Center for Allergic Hypersensitivity Disease

Inferred drug relations via UMLS 73 / NDF-RT 51 :

Cochrane evidence based reviews: hypersensitivity

Genetic Tests for Allergic Hypersensitivity Disease

Anatomical Context for Allergic Hypersensitivity Disease

MalaCards organs/tissues related to Allergic Hypersensitivity Disease:

Skin, Testes, Tongue, Eye

Publications for Allergic Hypersensitivity Disease

Articles related to Allergic Hypersensitivity Disease:

# Title Authors Year
Expression of FcgammaRIII (CD16) on human peripheral blood eosinophils increases in allergic conditions. ( 11897993 )

Variations for Allergic Hypersensitivity Disease

ClinVar genetic disease variations for Allergic Hypersensitivity Disease:

# Gene Variation Type Significance SNP ID Assembly Location
1 46;XX;t(4;14)(p15.2;q13)dn Translocation Likely pathogenic
2 SLC9A6 NM_001042537.1(SLC9A6): c.1346C> A (p.Ala449Glu) single nucleotide variant Uncertain significance GRCh37 Chromosome X, 135098913: 135098913
3 SLC9A6 NM_001042537.1(SLC9A6): c.1346C> A (p.Ala449Glu) single nucleotide variant Uncertain significance GRCh38 Chromosome X, 136016754: 136016754
4 GFOD1; MCUR1; NOL7; PHACTR1; RANBP9; RNF182; SIRT5; TBC1D7 GRCh37/hg19 6p24.1-23(chr6: 12536624-13968949) copy number gain Uncertain significance GRCh37 Chromosome 6, 12536624: 13968949

Expression for Allergic Hypersensitivity Disease

Search GEO for disease gene expression data for Allergic Hypersensitivity Disease.

Pathways for Allergic Hypersensitivity Disease

Pathways related to Allergic Hypersensitivity Disease according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
13.66 CCL11 FCER2 IFNG IL10 IL13 IL4
Show member pathways
13.5 CCL11 IFNG IL10 IL13 IL4 IL4R
Show member pathways
13.38 CCL11 IL10 IL13 IL4 IL4R IL5
Show member pathways
13.36 CCL11 FCER2 IFNG IL10 IL13 IL4
Show member pathways
13.27 CCL11 IL10 IL13 IL4 IL4R IL5
Show member pathways
12.89 CCL11 FCER2 IL4 IL4R IL9 STAT6
Show member pathways
12.85 CCL11 EPX IFNG IL10 IL13 IL4
9 12.83 IFNG IL13 IL4 IL4R IL5 STAT6
Show member pathways
12.75 CD79A IFNG IL4 IL4R TLR9
Show member pathways
12.65 IFNG IL10 IL13 IL4 IL4R IL5
Show member pathways
12.58 CD79A IL13 IL4 IL5 MS4A2
13 12.57 CD79A ENPP3 IFNG IL10 IL4 STAT6
Show member pathways
12.46 IFNG IL10 IL13 IL4 IL4R IL5
Show member pathways
12.42 IFNG IL10 IL4 IL5 IL9
Show member pathways
12.33 CCL11 IFNG IL13 IL4 IL5
Show member pathways
12.18 CCL11 IFNG IL4 TLR9
Show member pathways
12.09 CCL11 IFNG IL10 IL13 IL4 IL4R
19 12.03 CCL11 FCER2 IL10 IL13 IL4 IL4R
20 12.02 CD79A IFNG IL10 IL4 IL5
21 11.9 FCER2 IL4 IL4R IL5
22 11.89 IFNG IL10 IL4R STAT6
23 11.81 IFNG IL13 IL4 IL5
24 11.77 IFNG IL10 IL13 IL4 IL5 IL9
Show member pathways
11.73 IFNG IL4 IL5
26 11.71 IFNG IL10 TLR9
27 11.68 CCL11 IL13 IL4 IL5
28 11.56 FCER2 IL10 IL4R
29 11.56 FCER2 IL10 IL13 IL4
30 11.52 IFNG IL10 TLR9
31 11.5 CCL11 STAT6 TSLP
32 11.5 CCL11 FCER2 IL10 IL4 IL4R IL5
33 11.36 IFNG IL4 IL4R IL5
34 11.35 IFNG IL10 TLR9
35 11.33 IFNG IL10 IL13 IL4 IL5
36 11.24 IFNG IL13 IL4 IL5 IL9 TSLP
37 10.94 CCL11 IFNG IL10 IL13 IL4 IL4R
38 10.85 IFNG IL10 IL13 IL4 IL5 IL9

GO Terms for Allergic Hypersensitivity Disease

Cellular components related to Allergic Hypersensitivity Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 CCL11 CSN1S1 EPX IFNG IL10 IL13
2 extracellular region GO:0005576 9.53 CCL11 CSN1S1 ENPP3 EPX FCER2 IFNG
3 external side of plasma membrane GO:0009897 9.46 CD79A FCER2 IL13 MS4A2

Biological processes related to Allergic Hypersensitivity Disease according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.83 EPX IL10 LALBA RNASE3 TLR9
2 inflammatory response GO:0006954 9.8 CCL11 IL10 IL13 IL5 IL9 MS4A2
3 defense response to Gram-negative bacterium GO:0050829 9.78 LALBA RNASE3 TLR9
4 B cell differentiation GO:0030183 9.77 CD79A IL10 IL4
5 regulation of signaling receptor activity GO:0010469 9.76 CCL11 IFNG IL10 IL13 IL4 IL5
6 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.75 IFNG IL13 TSLP
7 negative regulation of endothelial cell apoptotic process GO:2000352 9.67 IL10 IL13 IL4
8 positive regulation of B cell proliferation GO:0030890 9.67 IL13 IL4 IL5 TLR9
9 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.62 FCER2 TLR9
10 response to molecule of bacterial origin GO:0002237 9.61 IL10 TLR9
11 positive regulation of mast cell degranulation GO:0043306 9.59 IL13 IL4R
12 positive regulation of interleukin-13 production GO:0032736 9.58 IL4 TSLP
13 positive regulation of macrophage activation GO:0043032 9.58 IL10 IL13 IL4R
14 positive regulation of MHC class II biosynthetic process GO:0045348 9.57 IL10 IL4
15 type 2 immune response GO:0042092 9.56 IL10 IL4
16 cytokine-mediated signaling pathway GO:0019221 9.56 CCL11 FCER2 IL10 IL13 IL4 IL4R
17 negative regulation of interleukin-8 production GO:0032717 9.55 IL10 TLR9
18 regulation of isotype switching GO:0045191 9.54 IL10 IL4
19 positive regulation of killing of cells of other organism GO:0051712 9.52 FCER2 IFNG
20 interleukin-4-mediated signaling pathway GO:0035771 9.51 IL4R STAT6
21 positive regulation of immunoglobulin production GO:0002639 9.5 IL13 IL4R TLR9
22 positive regulation of isotype switching to IgE isotypes GO:0048295 9.48 IL4 STAT6
23 negative regulation of complement-dependent cytotoxicity GO:1903660 9.46 IL13 IL4
24 immune response GO:0006955 9.32 CCL11 ENPP3 IFNG IL10 IL13 IL4

Molecular functions related to Allergic Hypersensitivity Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.56 IL10 IL4 IL5 IL9
2 cytokine activity GO:0005125 9.23 CCL11 IFNG IL10 IL13 IL4 IL5
3 IgE binding GO:0019863 9.16 FCER2 MS4A2
4 cytokine receptor binding GO:0005126 9.13 IL13 IL4 IL9

Sources for Allergic Hypersensitivity Disease

9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
70 SNOMED-CT via Orphanet
72 Tocris
74 UMLS via Orphanet
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