ALRH
MCID: ALL003
MIFTS: 69

Allergic Rhinitis (ALRH)

Categories: Genetic diseases, Immune diseases, Respiratory diseases, Skin diseases, Smell/Taste diseases

Aliases & Classifications for Allergic Rhinitis

MalaCards integrated aliases for Allergic Rhinitis:

Name: Allergic Rhinitis 58 12 76 38 30 56 15 41 17 74
Hay Fever 12 44 15 74 64
Allergic Rhinitis, Susceptibility to 58 13 6
Rhinitis, Allergic, Perennial 45 17 74
Seasonal Allergic Rhinitis 12 17
Atopic Rhinitis 12 74
Alrh 58 76
Non-Seasonal Allergic Rhinitis 12
Rhinitis, Allergic, Seasonal 45
Perenial Allergic Rhinitis 12
Rhinitis Allergic Seasonal 56
Rhinitis, Allergic 45
Pollenosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4481
OMIM 58 607154
KEGG 38 H01360
NCIt 51 C34987
SNOMED-CT 69 38103000
ICD10 34 J30.1
MedGen 43 C2607914

Summaries for Allergic Rhinitis

MedlinePlus : 44 Each spring, summer, and fall, trees, weeds, and grasses release tiny pollen grains into the air. Some of the pollen ends up in your nose and throat. This can trigger a type of allergy called hay fever. Symptoms can include Sneezing, often with a runny or clogged nose Coughing and postnasal drip Itching eyes, nose and throat Red and watery eyes Dark circles under the eyes Your health care provider may diagnose hay fever based on a physical exam and your symptoms. Sometimes skin or blood tests are used. Taking medicines and using nasal sprays can relieve symptoms. You can also rinse out your nose, but be sure to use distilled or sterilized water with saline. Allergy shots can help make you less sensitive to pollen and provide long-term relief. NIH: National Institute of Allergy and Infectious Diseases

MalaCards based summary : Allergic Rhinitis, also known as hay fever, is related to pollen allergy and giant papillary conjunctivitis, and has symptoms including tinnitus, snoring and rhinorrhea. An important gene associated with Allergic Rhinitis is IL13 (Interleukin 13), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs Allegra and Allegra-D have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and eye, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 A rhinitis that is an allergic inflammation and irritation of the nasal airways involving sneezing, runny nose, nasal congestion, itching and tearing of the eyes caused by exposure to an allergen such as pollen, dust, mold, animal dander and droppings of cockroaches or house dust mites.

UniProtKB/Swiss-Prot : 76 Allergic rhinitis: A common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure.

PubMed Health : 64 About hay fever: Many children and adults are affected by hay fever in the spring and summer months, when plants grow and bloom. Sneezing and itchy eyes can be a real problem, especially on days that are warm and dry. A lot of people who have allergies and asthma have more asthma attacks around this time of year too.Hay fever is an allergic reaction to pollen in the air, affecting the upper airways. The symptoms it causes are called allergic rhinitis.

Wikipedia : 77 Allergic rhinitis, also known as hay fever, is a type of inflammation in the nose which occurs when the... more...

Description from OMIM: 607154

Related Diseases for Allergic Rhinitis

Diseases related to Allergic Rhinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 245)
# Related Disease Score Top Affiliating Genes
1 pollen allergy 32.7 EPX ICAM1 IL13 IL4R IL5 RNASE3
2 giant papillary conjunctivitis 32.1 CCL11 CXCL8 IL4 RNASE3
3 churg-strauss syndrome 32.0 IL5 MPO RNASE3
4 ige responsiveness, atopic 31.8 IGHE IL13 IL4 IL4R IL5 MS4A2
5 vasomotor rhinitis 31.8 RNASE3 VIP
6 dermatitis 31.5 CCL11 IGHE IL13 IL4 IL5
7 urticaria 31.5 HRH1 IGHE RNASE3
8 sinusitis 31.4 CXCL8 IL4R IL5 RNASE3
9 cytokine deficiency 31.2 IL13 IL5
10 otitis media 31.0 CCL11 CXCL8 IGHE IL4 RNASE3
11 esophagitis, eosinophilic, 1 30.8 CCL11 IL13 IL5
12 esophagitis 30.6 CCL11 CXCL8 IL13 IL5
13 allergic bronchopulmonary aspergillosis 30.6 EPX IL4 IL5
14 chronic rhinitis 30.5 EPX MPO
15 pulmonary disease, chronic obstructive 30.5 CCL11 CXCL8 IL13 MPO RNASE3
16 rhinitis 30.5 CCL11 CXCL8 EPX FOXJ1 HRH1 ICAM1
17 blepharoconjunctivitis 30.4 CCL11 IL4 RNASE3
18 common cold 30.4 CCL11 CXCL8 ICAM1 IL13 IL5 RNASE3
19 hypereosinophilic syndrome 30.4 CCL11 EPX IGES IGHE IL13 IL4
20 tetanus 30.3 IL13 IL4 IL5
21 allergic conjunctivitis 30.3 CCL11 CXCL8 HRH1 ICAM1 IL13 IL4
22 cough variant asthma 30.3 IL4 IL5 NGF RNASE3
23 food allergy 30.2 EPX IL13 IL4 IL5 MS4A2 RNASE3
24 allergic asthma 30.1 CCL11 EPX IGHE IL13 IL4 IL4R
25 bronchitis 30.1 CCL11 CXCL8 IL5 MPO RNASE3 VIP
26 dermatitis, atopic 30.0 CCL11 CXCL8 EPX HRH1 ICAM1 IGES
27 cystic fibrosis 30.0 CXCL8 MPO RNASE3 VIP
28 lung disease 29.9 CXCL8 IL13 IL5 MPO RNASE3
29 vernal keratoconjunctivitis 29.9 CCL11 ICAM1 IL13 IL4 IL5 RNASE3
30 keratoconjunctivitis 29.7 CCL11 CXCL8 ICAM1 IL13 IL4 IL5
31 malaria 29.7 CCL11 CXCL8 HRH1 ICAM1 IL13 IL4
32 conjunctivitis 29.7 CCL11 CXCL8 EPX HRH1 ICAM1 IL13
33 respiratory allergy 29.5 CCL11 IGHE IL13 IL4 IL4R IL5
34 allergic hypersensitivity disease 28.7 CCL11 EPX HRH1 IGES IGHE IL13
35 asthma 28.1 ALOX5 CCL11 CXCL8 EPX HAVCR1 HRH1
36 asthma-related traits 4 12.2
37 carboxypeptidase n deficiency 11.1
38 netherton syndrome 11.1
39 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 IL13 IL5
40 loeffler endocarditis 10.5 IL5 RNASE3
41 pemphigoid gestationis 10.4 CCL11 IL5
42 paragonimiasis 10.4 IL13 IL5 RNASE3
43 prurigo nodularis 10.4 NGF RNASE3
44 respiratory syncytial virus infectious disease 10.4 IL13 IL5
45 penicillin allergy 10.4 IL13 IL4 IL4R
46 strongyloidiasis 10.4 CCL11 IL13 IL5
47 beta-lactam allergy 10.4 IL13 IL4 IL4R
48 eosinophilic granuloma 10.4 EPX RNASE3
49 sleep apnea 10.4
50 nickel allergic contact dermatitis 10.4 IL13 IL4 IL5

Comorbidity relations with Allergic Rhinitis via Phenotypic Disease Network (PDN):


Anxiety Bronchitis
Esophagitis Hypertension, Essential
Hypothyroidism

Graphical network of the top 20 diseases related to Allergic Rhinitis:



Diseases related to Allergic Rhinitis

Symptoms & Phenotypes for Allergic Rhinitis

Clinical features from OMIM:

607154

UMLS symptoms related to Allergic Rhinitis:


tinnitus, snoring, rhinorrhea, sore throat, coughing, vertigo/dizziness, equilibration disorder

MGI Mouse Phenotypes related to Allergic Rhinitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.9 ALOX5 CCL11 EPX HRH1 ICAM1 IL13
2 immune system MP:0005387 9.73 ALOX5 CCL11 EPX HRH1 ICAM1 IL13
3 respiratory system MP:0005388 9.17 CCL11 FOXJ1 IL13 IL4 IL4R IL5

Drugs & Therapeutics for Allergic Rhinitis

PubMedHealth treatment related to Allergic Rhinitis: 64

Various medications are available to treat the symptoms:AntihistaminesSteroids (corticosteroids)Chromones (mast cell stabilizers)Leukotriene receptor antagonistsDecongestant nasal drops and spraysThere are also non-drug alternatives such as saline (salt water) nasal sprays and nasal washes (nasal irrigation).Allergen-specific immunotherapy (also known as desensitization) can reduce your sensitivity to allergens over the long term. Like with vaccines, this treatment approach involves being exposed to small amounts of the substance by having it injected or placing it under your tongue. In allergen-specific immunotherapy, you are exposed to the allergen at regular intervals. The treatment takes about three years to complete.

FDA approved drugs:

(show all 19)
# Drug Name Active Ingredient(s) 19 Company Approval Date
1
Allegra 19 FEXOFENADINE HYDROCHLORIDE Hoechst Marion Roussel July 1996
2
Allegra-D 19 FEXOFENADINE HYDROCHLORIDE; PSEUDOEPHEDRINE HYDROCHLORIDE Hoechst Marion Roussel March 1998
3
Astelin nasal spray 19 AZELASTINE HYDROCHLORIDE Wallace Laboratories November 1996
4
Atrovent 19 IPRATROPIUM BROMIDE Boehringer Ingelheim January 1996
5
Clarinex 19 DESLORATADINE Schering-Plough February 2002
6
Claritin RediTabs 19 LORATADINE Schering-Plough January 1997
7
Clemastine fumarate syrup 19 CLEMASTINE FUMARATE Morton Grove Pharmaceuticals March 1998
8
Dymista 19 AZELASTINE HYDROCHLORIDE; FLUTICASONE PROPIONATE Meda Pharmaceuticals Inc May 2012
9
Flonase Nasal Spray 19 FLUTICASONE PROPIONATE GlaxoSmithKline November 1997
10
Grastek 19 Timothy Grass Pollen Allergen Extract Merck April 2014
11
Nasacort AQ Nasal Spray 19 TRIAMCINOLONE ACETONIDE Phone-Poulenc Rorer October 1997
12
Oralair 19 Greer Labs April 2014
13
Patanase 19 OLOPATADINE HYDROCHLORIDE Alcon April 2008
14
Qnasl 19 BECLOMETHASONE DIPROPIONATE Teva Pharmaceutical March 2012
15
Ragwitek 19 Merck April 2014
16
Rhinocort Aqua Nasal Spray 19 BUDESONIDE AstraZeneca October 1999
17
Tri-Nasal Spray 19 Muro Pharmaceutical February 2000
18
Xyzal 19 LEVOCETIRIZINE DIHYDROCHLORIDE UCB May 2007
19
Zyrtec 19 CETIRIZINE HYDROCHLORIDE Pfizer December 1995

Drugs for Allergic Rhinitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 365)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-45-6 774
2
Capsaicin Approved Phase 4 404-86-4 1548943
3
Montelukast Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 158966-92-8 5281040
4
Nitric Oxide Approved Phase 4,Not Applicable 10102-43-9 145068
5
Cetirizine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83881-51-0 2678
6
Azelastine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58581-89-8 2267
7
Fluticasone Approved, Experimental Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 90566-53-3 62924
8
Levocetirizine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 130018-77-8 1549000
9
Ephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 299-42-3 9294
10
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
11
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3 302-25-0
12
Xylometazoline Approved, Investigational Phase 4,Not Applicable 526-36-3 5709
13
mometasone furoate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83919-23-7
14
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3 2921-57-5
15
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
16
Pseudoephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 90-82-4 7028
17
Desloratadine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 100643-71-8 124087
18
Loratadine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 79794-75-5 3957
19
Oxymetazoline Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1491-59-4 4636
20
Phenylephrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59-42-7 6041
21
Betamethasone Approved, Vet_approved Phase 4,Phase 3 378-44-9 9782
22
Omalizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 242138-07-4
23
Ciclesonide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 141845-82-1, 126544-47-6 444033
24
Budesonide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51333-22-3 63006 5281004
25
Fexofenadine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 83799-24-0 3348
26
Resveratrol Approved, Experimental, Investigational Phase 4,Phase 3 501-36-0 445154
27
Adenosine Approved, Investigational Phase 4,Phase 2,Phase 1 58-61-7 60961
28
Doxazosin Approved Phase 4 74191-85-8 3157
29
Triamcinolone Approved, Vet_approved Phase 4,Phase 3 124-94-7 31307
30
Racepinephrine Approved Phase 4,Phase 3,Phase 1 329-65-7 838
31
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 1 51-43-4 5816
32
Promethazine Approved, Investigational Phase 4,Phase 1 60-87-7 4927
33
Diphenhydramine Approved, Investigational Phase 4,Phase 1 147-24-0, 58-73-1 3100
34
Prazosin Approved Phase 4 19216-56-9 4893
35
Theophylline Approved Phase 4,Phase 2 58-55-9 2153
36
Sodium Citrate Approved, Investigational Phase 4,Phase 2 68-04-2
37
Almotriptan Approved, Investigational Phase 4 181183-52-8, 154323-57-6 123606
38
Pimecrolimus Approved, Investigational Phase 4 137071-32-0 17753757 6447131
39
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492 6473866
40
Epinastine Approved, Investigational Phase 4,Phase 3,Phase 2 80012-43-7 3241
41
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 2,Phase 3 50-14-6 5280793
42
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3 1406-16-2
43
Vitamin D3 Approved, Nutraceutical Phase 4,Phase 2,Phase 3 67-97-0 5280795 6221
44
Calcium Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1 7440-70-2 271
45
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 77-92-9 311
46
Prednisolone hemisuccinate Experimental Phase 4,Phase 3 2920-86-7
47
Tranilast Investigational Phase 4 53902-12-8 93543
48
Histamine Phosphate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-74-1 65513
49 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
50 Histamine H1 Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 1032)
# Name Status NCT ID Phase Drugs
1 Immunological Mechanisms of Oralair® in Patients With Seasonal Allergic Rhinitis Unknown status NCT02014623 Phase 4 Control
2 Assessment of Sublingual Immunotherapy in Children Allergic to House Dust Mites Unknown status NCT01052610 Phase 4 sublingual house dust mites allergen extract;placebo in sublingual applicator
3 Comparative Study of Sinol and Sinol-M in Patients With Congestion Due to Allergic Rhinitis Unknown status NCT00825656 Phase 4 Sinol or Sinol-M nasal spray
4 Comparison of the Effect of Montelukast and Cetirizine on Allergic Inflammation in Children With Allergic Rhinitis Unknown status NCT00488176 Phase 4 montelukast;cetirizine;montelukast and cetirizine;placebo
5 Evaluating Factors Involved in Dymista's Superior Clinical Efficacy to Fluticasone Propionate in the Treatment of Seasonal Allergic Rhinitis Unknown status NCT02402465 Phase 4 Placebo;Fluticasone propionate;Fluticasone/Azelastine nasal spray
6 AZELASTINE/FLUTICASONE (AZE/FLU) Nasal Spray on Symptom Control, Nasal Mediators and Nasal Hyperresponsiveness in Allergic Rhinitis (AR) Unknown status NCT02238353 Phase 4 azelastine + fluticasone;Placebo
7 Cosalin® Monotherapy Versus Cosalin® and Xarlin® Combination Therapy Unknown status NCT01062139 Phase 4 Xarlin (Levocetirizine);Cosalin (Petasites hybridus CO2 extract)
8 4"S" - Seasonal Symptoms Suppression Study Unknown status NCT02557269 Phase 4 Xylometazoline - intranasal application;Azelastine - intranasal application;Mometasone furoate - intranasal application;Hydroxyl-propyl-methyl cellulose powder - intranasal application;Bilastine 20 mg;Prednisolone 5 mg
9 Elaboration of Patient-friendly Treatment Strategy With Capsaicin Nasal Spray in Patients With Idiopathic Rhinitis Unknown status NCT02288156 Phase 4 Capsaicin;placebo
10 POLlinosis and Exhaled Breath Temperature Unknown status NCT01785394 Phase 4 5 grass allergen extract
11 Can we Help People With the Oral Allergy Syndrome Eat Fresh Fruit? Unknown status NCT01431859 Phase 4
12 Sunovion Growth Study Pediatric Subjects With Mild Asthma & Allergic Rhinitis Completed NCT01550471 Phase 4 Alvesco/Omnaris, QVAR/Beconase, Placebo/Placebo;Alvesco/Omnaris, Placebo/Placebo, QVAR/Beconase;QVAR/Beconase, Alvesco/Omnaris, Placebo/Placebo;QVAR/Beconase, Placebo/Placebo, Alvesco/Omnaris;Placebo/Placebo, Alvesco/Omnaris, QVAR/Beconase;Placebo/Placebo, QVAR/Beconase, Alvesco/Omnaris
13 Anti-inflammatory H1 Antihistamines Allergic Rhinitis Completed NCT02507635 Phase 4 Levocetirizine;Desloratadine
14 Comparison of Effectiveness and Safety of Sublingual Immunotherapy in Children With Allergic Rhinitis Completed NCT00698594 Phase 4
15 Quality of Life in Patients With Allergic Rhinitis: Clinical Trial With Bilastine or Loratadine Completed NCT02513290 Phase 4 Bilastine;Loratadine
16 Role of Montelukast in Asthma and Allergic Rhinitis Patients Not yet recruiting NCT03380975 Phase 4 Montelukast 10mg
17 Nasal Budesonide Efficacy on Nasal FeNO in Children With Allergic Rhinitis Completed NCT02409563 Phase 4 Budesonide nasal spray (100 mcg bid);Budesonide nasal spray (50 mcg bid
18 Montelukast and Fexofenadine Versus Montelukast and Levocetrizine Combination in Allergic Rhinitis Completed NCT02551536 Phase 4 Montelukast;Fexofenadine;Levocetrizine
19 Efficacy and Safety of Lectranal® in Treatment of Seasonal Allergic Rhinitis Symptoms Completed NCT00460538 Phase 4
20 Nebulized Beclometasone Dipropionate Improves Nasal Patency in Children With Allergic Rhinitis Completed NCT02646904 Phase 4 Nasal Beclomethasone Dipropionate;CERCHIO 10 mg/ml OS
21 Seasonal Allergic Rhinitis and Driving Ability Terminated NCT00223587 Phase 4
22 Effectiveness Of Therapy With A Thermal Water Nasal Aerosol In Children With Seasonal Allergic Rhinitis Completed NCT01326247 Phase 4
23 Comparison of Olopatadine 0.6% and Fluticasone Proprionate 50mcg Nasal Sprays in a Two Week Seasonal Allergic Rhinitis Trial Completed NCT00691665 Phase 4 Olopatadine HCL Nasal Spray, 0.6%;Fluticasone Propionate Nasal Spray, 50 mcg
24 Montelukast in Mild Asthmatic Children With Allergic Rhinitis (0476-367) Completed NCT00442559 Phase 4 montelukast sodium;inhaled corticosteroid
25 Levocetirizine 5 mg: Reduction of Symptoms, Airway Resistance and Sleep Impairment in Persistent Allergic Rhinitis Completed NCT00355771 Phase 4 Levocetirizine;Placebo
26 Nebulized Resveratrol Plus Carboxymethyl-β-Glucan for Reducing IL-5 in Children With Allergic Rhinitis Completed NCT03349619 Phase 4 Resveratrol plus Carboxymethyl-β-Glucan;Placebo
27 POPULAR (Preference Of Patient Using Levocetirizine in Allergic Rhinitis) Completed NCT00160537 Phase 4 Levocetirizine
28 To Evaluate Adenosine Monophosphate and Allergen Challenge in Allergic Rhinitis Completed NCT00679250 Phase 4 levocetirizine;placebo to levocetirizine
29 Comparison of the Effects of Nasal Steroids and Montelukast on Olfactory Functions in Patients With Allergic Rhinitis Completed NCT02565212 Phase 4 Montelukast,mometazon froat
30 Fluticasone and Salmeterol in Allergic Rhinitis Completed NCT01388595 Phase 4 FLUTICASONE PROPRIONATE;Salmeterol;PLACEBO
31 Effects of Hypertonic Saline Solution (NACL 3%+NAHCO3) on Nasal Inflammation in Children With AR. RinASol- Pilot Study Completed NCT02729012 Phase 4 hypertonic saline solution (NACL 3%+NAHCO3)
32 Alpha-Blockers in Allergic Rhinitis (MAN 01) Completed NCT01946035 Phase 4 Doxazosin XL
33 Children, Perennial Allergic Rhinitis (PAR), l-t Growth Completed NCT00641212 Phase 4 Budesonide;Placebo
34 Efficacy and Tolerability of a Topical Microemulsion in Patients With Allergic Rhinitis Due to Sensitization to Pollen Completed NCT01478425 Phase 4
35 A Study Evaluating the Efficacy and Impact on Health-related Quality of Life of Levocetirizine in Adults With Seasonal Allergic Rhinitis Completed NCT00653224 Phase 4 levocetirizine dihydrochloride;placebo
36 A Study Evaluating the Efficacy and Impact on Health-related Quality of Life of Levocetirizine in Adults With Seasonal Allergic Rhinitis Completed NCT00621959 Phase 4 levocetirizine dihydrochloride;placebo
37 Safety of PATANASE Nasal Spray in Patients With Perennial Allergic Rhinitis Completed NCT00789555 Phase 4 Olopatadine hydrochloride 0.6% nasal spray (PATANASE)
38 Levocetirizine Effect on Nasal Nitric Oxide and Nasal Eosinophils in Subjects With Perennial Allergic Rhinitis Completed NCT00894231 Phase 4 levocetirizine (Xyzal);placebo
39 Single-Center, Double-Blind, Randomized , Parallel Study Comparing Onset of Action, Efficacy & Safety of a Single-Dose of Fexofenadine HCl 180 mg vs Montelukast Na 10 mg & Placebo in Treating Seasonal Allergic Rhinitis Subjects in an Allergen Exposure Unit Completed NCT00637611 Phase 4 Fexofenadine HCl
40 Study of Nasonex® in Improving Sleep Disturbances Related to Perennial Allergic Rhinitis (Study P04909)(TERMINATED) Terminated NCT00491374 Phase 4 Mometasone Furoate Nasal Spray;Placebo
41 Fluticasone Furoate Treatment of Daytime Somnolence and Cognitive Performance in Seasonal Allergic Rhinitis Completed NCT00997620 Phase 4 Fluticasone furoate Nasal Spray 110 mcg;Placebo
42 Azelastine Fluticasone Combination vs. Fluticasone Withdrawn NCT00845598 Phase 4 Azelastine , fluticasone;Fluticasone propionate
43 Allergic Rhinitis Changes the Sinus Microbiome Completed NCT01852513 Phase 4 QNASL;Placebo nasal spray
44 Preventing Tolerance to Oxymetazoline in Allergic Rhinitis Withdrawn NCT00846326 Phase 4 oxymetazoline-fluticasone propionate;Oxymetazoline
45 A Randomized, Placebo Controlled Study to Determine the Efficacy and Speed of a Nasal Spray in Allergen Induced Seasonal Allergic Rhinitis Completed NCT00561717 Phase 4 Azelastine and placebo;Loratadine and Placebo;Cetirizine and Placebo;Placebo and Placebo (spray and Tablet)
46 A Clinical Study To Test A Nasal Spray (Fluticasone Furoate Nasal Spray) For The Treatment Of Perennial (Year-round) Allergic Rhinitis Completed NCT00609674 Phase 4 Fluticasone furoate nasal spray;Placebo
47 Safety of Astepro 0.15% Nasal Spray and Astepro 0.1% Nasal Spray in Children Ages >6 Months to <6 Years With AR Completed NCT01880840 Phase 4 205.5 mcg of azelastine hydrochloride;137 mcg of azelastine hydrochloride
48 Study of Bronchodilation Effects of Cetirizine Completed NCT01781507 Phase 4 Cetirizine;Placebo
49 Efficacy & Safety of Loratadine-Betamethasone Oral Solution for Treatment of Severe Perennial Allergic Rhinitis in Children (Study P03428) Completed NCT00963573 Phase 4 Loratadine;Betamethasone
50 Onset of Effect of Mometasone Nasal Spray in Induced Allergic Rhinitis (Study P03431) Completed NCT00783237 Phase 4 Mometasone;Placebo

Search NIH Clinical Center for Allergic Rhinitis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: rhinitis, allergic, seasonal

Genetic Tests for Allergic Rhinitis

Genetic tests related to Allergic Rhinitis:

# Genetic test Affiliating Genes
1 Allergic Rhinitis 30 IL13

Anatomical Context for Allergic Rhinitis

MalaCards organs/tissues related to Allergic Rhinitis:

42
Testes, Skin, Eye, T Cells, Neutrophil, Lung, Pituitary

Publications for Allergic Rhinitis

Articles related to Allergic Rhinitis:

(show top 50) (show all 4785)
# Title Authors Year
1
Efficacy of Sublingual Administration of Dermatophagoides Farinae Drops for Treatment of Pediatric Allergic Rhinitis Accompanied by Adenoid Hypertrophy and Improvement of Immune Function. ( 30633736 )
2019
2
Dendritic cells modified with Der p1 antigen as a therapeutic potential for allergic rhinitis in a murine model via regulatory effects on IL-4, IL-10 and IL-13. ( 30851701 )
2019
3
Nonylphenol can aggravate allergic rhinitis in a murine model by regulating important Th cell subtypes and their associated cytokines. ( 30851706 )
2019
4
Association of antimicrobial household exposure with development of allergic rhinitis in Korea. ( 30861215 )
2019
5
Recent Patents in Allergy/Immunology: Use of arginase inhibitors in the treatment of asthma and allergic rhinitis. ( 30865303 )
2019
6
The Comparation of Intraperitoneal Injection and Nasal-only Delivery Allergic Rhinitis Model Challenged With Different Allergen Concentration. ( 30871345 )
2019
7
The ameliorative effect of AST2017-01 in an ovalbumin-induced allergic rhinitis animal model. ( 30874868 )
2019
8
Consensus on the methodology for experimental studies in allergic rhinitis. ( 30877977 )
2019
9
Epigenetic changes: An emerging potential pharmacological target in allergic rhinitis. ( 30878818 )
2019
10
Triamcinolone Acetonide versus Fluticasone Propionate in the Treatment of Perennial Allergic Rhinitis: A Randomized, Parallel-Group Trial. ( 30879006 )
2019
11
Gallic acid alleviates nasal inflammation via activation of Th1 and inhibition of Th2 and Th17 in a mouse model of allergic rhinitis. ( 30884431 )
2019
12
Bronchial asthma triggered by house dust mites in patients with local allergic rhinitis. ( 30887534 )
2019
13
Life-long endogenous estrogen exposure is associated with prevalence of allergic rhinitis in postmenopausal women. ( 30889092 )
2019
14
Metabolomics analysis of baicalin on ovalbumin-sensitized allergic rhinitis rats. ( 30891260 )
2019
15
Prevalence of local allergic rhinitis to Dermatophagoides pteronyssinus in chronic rhinitis with negative skin prick test. ( 30903999 )
2019
16
A Prospective Study of Outcomes of Septoplasty with Turbinate Reductions in Patients with Allergic Rhinitis. ( 30909804 )
2019
17
Efficacy and safety of olopatadine/mometasone combination nasal spray for the treatment of seasonal allergic rhinitis. ( 30910440 )
2019
18
Effect of Prostaglandin E1 Analog Misoprostol in An Ovalbumin-Induced Allergic Rhinitis Model. ( 30911262 )
2019
19
Powder Cellulose in Allergic Rhinitis Management: Relevance of in vitro Findings to Real-Life Safety. ( 30913556 )
2019
20
Clinical Response to Subcutaneous Dermatophagoides pteronyssinus Immunotherapy in Children with Allergic Rhinitis and Asthma Is Independent of Sensitization to Blomia tropicalis Allergens. ( 30544116 )
2019
21
The protective role of Piper nigrum fruit extract in an ovalbumin-induced allergic rhinitis by targeting of NFκBp65 and STAT3 signalings. ( 30551446 )
2019
22
Suppressive Activity of Adiponectin on the Development of Allergic Rhinitis in Mice. ( 30587608 )
2019
23
The relationship between IL-17A and IL-22 expression and clinical severity in patients with moderate/severe persistent allergic rhinitis. ( 30594402 )
2019
24
The Characteristics of Severe Chronic Upper-Airway Disease (SCUAD) in Patients with Allergic Rhinitis: A Real-Life Multicenter Cross-Sectional Italian Study. ( 30605899 )
2019
25
Acupuncture as an add-on therapy to sublingual allergen-specific immunotherapy for patients with allergic rhinitis. ( 30608427 )
2019
26
Early-Life Environmental Factors, IFN-γ Methylation Patterns, and Childhood Allergic Rhinitis. ( 30612129 )
2019
27
Bioinformatics-Based Approaches Predict That MIR-17-5P Functions in the Pathogenesis of Seasonal Allergic Rhinitis Through Regulating ABCA1 and CD69. ( 30616374 )
2019
28
The role of anxious temperament in patients with allergic rhinitis. ( 30617380 )
2019
29
Antihistamines for Allergic Rhinitis Treatment from the Viewpoint of Nonsedative Properties. ( 30626077 )
2019
30
Effectiveness of Hypertonic Saline Nasal Irrigation for Alleviating Allergic Rhinitis in Children: A Systematic Review and Meta-Analysis. ( 30634447 )
2019
31
Differential Expression of Fas in Moderate/Severe and Mild Persistent Allergic Rhinitis and Its Correlation With Pathological Parameters. ( 30648403 )
2019
32
Intranasal Steroid Therapy for Allergic Rhinitis. ( 30653642 )
2019
33
Impact of moderate-severe persistent allergic rhinitis on thoraco-abdominal kinematics and respiratory muscle function. ( 30656995 )
2019
34
Chinese herbal medicine bi min fang for allergic rhinitis: protocol for a double-blind, double-dummy, randomized controlled trial. ( 30658660 )
2019
35
MP-AzeFlu provides rapid and effective allergic rhinitis control: results of a non-interventional study in Denmark. ( 30659752 )
2019
36
Biosynthesis of gold nanoparticles using Caffeoylxanthiazonoside, chemical isolated from Xanthium strumarium L. fruit and their Anti-allergic rhinitis effect- a traditional Chinese medicine. ( 30660926 )
2019
37
Increasing Prevalence of Allergic Rhinitis in China. ( 30661309 )
2019
38
Intranasal Treatment With 1, 25-Dihydroxyvitamin D3 Alleviates Allergic Rhinitis Symptoms in a Mouse Model. ( 30661318 )
2019
39
IL-37 attenuates allergic process via STAT6/STAT3 pathways in murine allergic rhinitis. ( 30665041 )
2019
40
Stem cells from human exfoliated deciduous teeth correct the immune imbalance of allergic rhinitis via Treg cells in vivo and in vitro. ( 30670101 )
2019
41
Decreased Treg-derived miR-181a and miR-155 correlated with reduced number and function of Treg cells in allergic rhinitis children. ( 30673848 )
2019
42
New drugs in early-stage clinical trials for allergic rhinitis. ( 30676119 )
2019
43
Efficacy of a Novel Intranasal Formulation of Azelastine Hydrochloride and Fluticasone Propionate, Delivered in a Single Spray, for the Treatment of Seasonal Allergic Rhinitis: Results from Russia. ( 30677766 )
2019
44
Detection of Local Allergic Rhinitis in children with chronic, difficult-to-treat, non-allergic rhinitis using Multiple Nasal Provocation Tests. ( 30685887 )
2019
45
Interleukin-5 induces apoptotic defects in CD4+ T cells of patients with allergic rhinitis. ( 30694585 )
2019
46
Effects of Intranasal Cellulose Powder on Asthma Control in Children With Mild-to-Moderate Perennial Allergic Rhinitis: A Randomized, Placebo-Controlled Trial. ( 30704266 )
2019
47
Prevalence of symptoms of asthma and allergic rhinitis in children in Southern Brazil: a ten-year monitoring study. ( 30720381 )
2019
48
Fast up-dosing with a birch allergoid is safe and well tolerated in allergic rhinitis patients with or without asthma. ( 30730274 )
2019
49
The association between allergic rhinitis and otitis media: A national representative sample of in South Korean children. ( 30733549 )
2019
50
Early molecular biomarkers predicting the evolution of allergic rhinitis and its comorbidities: A longitudinal multicenter study of a patient cohort. ( 30734368 )
2019

Variations for Allergic Rhinitis

ClinVar genetic disease variations for Allergic Rhinitis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 IL13 NM_002188.2(IL13): c.431A> G (p.Gln144Arg) single nucleotide variant risk factor rs20541 GRCh37 Chromosome 5, 131995964: 131995964
2 IL13 NM_002188.2(IL13): c.431A> G (p.Gln144Arg) single nucleotide variant risk factor rs20541 GRCh38 Chromosome 5, 132660272: 132660272

Expression for Allergic Rhinitis

LifeMap Discovery
Genes differentially expressed in tissues of Allergic Rhinitis patients vs. healthy controls: 35
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 CST1 cystatin SN Respiratory System + 6.00 0.000
Search GEO for disease gene expression data for Allergic Rhinitis.

Pathways for Allergic Rhinitis