MCID: ALL003
MIFTS: 67

Allergic Rhinitis

Categories: Genetic diseases, Respiratory diseases, Immune diseases

Aliases & Classifications for Allergic Rhinitis

MalaCards integrated aliases for Allergic Rhinitis:

Name: Allergic Rhinitis 57 12 75 37 29 55 15 40 73
Hay Fever 12 43 63 73
Allergic Rhinitis, Susceptibility to 57 13 6
Rhinitis, Allergic, Perennial 44 73
Atopic Rhinitis 12 73
Alrh 57 75
Non-Seasonal Allergic Rhinitis 12
Rhinitis, Allergic, Seasonal 44
Perenial Allergic Rhinitis 12
Seasonal Allergic Rhinitis 12
Rhinitis Allergic Seasonal 55
Pollenosis 12

Classifications:



External Ids:

OMIM 57 607154
Disease Ontology 12 DOID:4481
NCIt 50 C34987
SNOMED-CT 68 38103000
MedGen 42 C2607914
KEGG 37 H01360
ICD10 33 J30.1

Summaries for Allergic Rhinitis

MedlinePlus : 43 Each spring, summer, and fall, trees, weeds, and grasses release tiny pollen grains into the air. Some of the pollen ends up in your nose and throat. This can trigger a type of allergy called hay fever. Symptoms can include Sneezing, often with a runny or clogged nose Coughing and postnasal drip Itching eyes, nose and throat Red and watery eyes Dark circles under the eyes Your health care provider may diagnose hay fever based on a physical exam and your symptoms. Sometimes skin or blood tests are used. Taking medicines and using nasal sprays can relieve symptoms. You can also rinse out your nose, but be sure to use distilled or sterilized water with saline. Allergy shots can help make you less sensitive to pollen and provide long-term relief. NIH: National Institute of Allergy and Infectious Diseases

MalaCards based summary : Allergic Rhinitis, also known as hay fever, is related to pollen allergy and sinusitis, and has symptoms including coughing, snoring and tinnitus. An important gene associated with Allergic Rhinitis is IL13 (Interleukin 13), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Allegra and Allegra-D have been mentioned in the context of this disorder. Affiliated tissues include testes, eye and skin, and related phenotypes are hematopoietic system and digestive/alimentary

Disease Ontology : 12 A rhinitis that is an allergic inflammation and irritation of the nasal airways involving sneezing, runny nose, nasal congestion, itching and tearing of the eyes caused by exposure to an allergen such as pollen, dust, mold, animal dander and droppings of cockroaches or house dust mites.

UniProtKB/Swiss-Prot : 75 Allergic rhinitis: A common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure.

PubMed Health : 63 About hay fever: Many children and adults are affected by hay fever in the spring and summer months, when plants grow and bloom. Sneezing and itchy eyes can be a real problem, especially on days that are warm and dry. A lot of people who have allergies and asthma have more asthma attacks around this time of year too.Hay fever is an allergic reaction to pollen in the air, affecting the upper airways. The symptoms it causes are called allergic rhinitis.

Wikipedia : 76 Allergic rhinitis, also known as hay fever, is a type of inflammation in the nose which occurs when the... more...

Description from OMIM: 607154

Related Diseases for Allergic Rhinitis

Diseases related to Allergic Rhinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 195)
# Related Disease Score Top Affiliating Genes
1 pollen allergy 32.5 EPX ICAM1 IL13 IL4R IL5 RNASE3
2 sinusitis 31.4 CXCL8 IL4R IL5 RNASE3
3 otitis media 31.1 CCL11 CXCL8 IGHE RNASE3
4 urticaria 31.1 HRH1 MS4A2 RNASE3
5 allergic bronchopulmonary aspergillosis 31.0 EPX IL4 IL5
6 blepharoconjunctivitis 30.9 CCL11 IL4 RNASE3
7 cough variant asthma 30.6 IL4 IL5 NGF RNASE3
8 dermatitis 30.2 CCL11 IGES IGHE IL13 IL4 IL5
9 common cold 30.2 CCL11 CXCL8 ICAM1 IL13 IL5 RNASE3
10 bronchitis 30.2 CCL11 CXCL8 IL5 MPO RNASE3
11 ige responsiveness, atopic 29.9 HAVCR1 IGES IGHE IL13 IL4 IL4R
12 pulmonary disease, chronic obstructive 29.9 CCL11 CXCL8 IL13 MPO RNASE3
13 vernal keratoconjunctivitis 29.8 CCL11 ICAM1 IL13 IL4 IL5 RNASE3
14 allergic conjunctivitis 29.7 CCL11 CXCL8 HRH1 ICAM1 IL13 IL4
15 food allergy 29.7 EPX IL13 IL4 IL5 MS4A2 RNASE3
16 keratoconjunctivitis 29.0 CCL11 CXCL8 ICAM1 IL13 IL4 IL5
17 conjunctivitis 28.9 CCL11 CXCL8 EPX ICAM1 IL13 IL4
18 allergic asthma 28.8 CCL11 CXCL8 EPX IGHE IL13 IL4
19 rhinitis 28.4 CCL11 CXCL8 EPX FOXJ1 HRH1 ICAM1
20 dermatitis, atopic 28.0 CCL11 CXCL8 EPX HRH1 ICAM1 IGHE
21 asthma 23.9 ALOX5 CCL11 CXCL8 EPX HAVCR1 HRH1
22 asthma-related traits 4 12.0
23 cytokine deficiency 11.0 IL13 IL5
24 loeffler endocarditis 11.0 IL5 RNASE3
25 angioimmunoblastic lymphadenopathy with dysproteinemia 10.9 IL13 IL5
26 pemphigoid gestationis 10.9 CCL11 IL5
27 paragonimiasis 10.9 IL13 IL5 RNASE3
28 penicillin allergy 10.9 IL13 IL4 IL4R
29 prurigo nodularis 10.9 NGF RNASE3
30 strongyloidiasis 10.9 CCL11 IL13 IL5
31 beta-lactam allergy 10.9 IL13 IL4 IL4R
32 esophagitis, eosinophilic, 1 10.8 CCL11 IL13 IL5
33 night blindness, congenital stationary, type 1a 10.8 CCL11 IL13 IL5
34 eosinophilic granuloma 10.8 EPX RNASE3
35 mercury poisoning 10.8 IL13 IL18
36 apple allergy 10.8 IL13 IL4 IL5
37 intestinal schistosomiasis 10.8 IL13 IL4 IL5
38 bagassosis 10.8 CXCL8 IL5
39 chronic tic disorder 10.8 IL13 IL4 IL5
40 respiratory syncytial virus infectious disease 10.8 IL13 IL5
41 intrinsic asthma 10.8 IL4 IL5 RNASE3
42 vasomotor rhinitis 10.8
43 hyper ige syndrome 10.8 IGHE IL4 IL4R
44 enterobiasis 10.8 IL13 IL4 IL5
45 egg allergy 10.8 IGHE IL4 IL5
46 toxicodendron dermatitis 10.8 CXCL8 ICAM1
47 conjunctival nevus 10.8 EPX NGF RNASE3
48 folliculitis 10.8 CCL11 IL4 IL5
49 toxic oil syndrome 10.8 IGHE IL4 IL5
50 milk allergy 10.8 IL4 IL5 RNASE3

Comorbidity relations with Allergic Rhinitis via Phenotypic Disease Network (PDN):


Anxiety Bronchitis
Esophagitis Hypertension, Essential
Hypothyroidism

Graphical network of the top 20 diseases related to Allergic Rhinitis:



Diseases related to Allergic Rhinitis

Symptoms & Phenotypes for Allergic Rhinitis

Clinical features from OMIM:

607154

UMLS symptoms related to Allergic Rhinitis:


coughing, snoring, tinnitus, sore throat, vertigo/dizziness, equilibration disorder, rhinorrhea

MGI Mouse Phenotypes related to Allergic Rhinitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.73 MS4A2 ALOX5 CCL11 EPX HRH1 ICAM1
2 digestive/alimentary MP:0005381 9.7 FOXJ1 ICAM1 IL13 IL18 IL4 IL4R
3 immune system MP:0005387 9.4 ALOX5 CCL11 EPX HRH1 ICAM1 IL13

Drugs & Therapeutics for Allergic Rhinitis

PubMedHealth treatment related to Allergic Rhinitis: 63

Various medications are available to treat the symptoms:AntihistaminesSteroids (corticosteroids)Chromones (mast cell stabilizers)Leukotriene receptor antagonistsDecongestant nasal drops and spraysThere are also non-drug alternatives such as saline (salt water) nasal sprays and nasal washes (nasal irrigation).Allergen-specific immunotherapy (also known as desensitization) can reduce your sensitivity to allergens over the long term. Like with vaccines, this treatment approach involves being exposed to small amounts of the substance by having it injected or placing it under your tongue. In allergen-specific immunotherapy, you are exposed to the allergen at regular intervals. The treatment takes about three years to complete.

FDA approved drugs:

(show all 19)
# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Allegra 18 FEXOFENADINE HYDROCHLORIDE Hoechst Marion Roussel July 1996
2
Allegra-D 18 FEXOFENADINE HYDROCHLORIDE; PSEUDOEPHEDRINE HYDROCHLORIDE Hoechst Marion Roussel March 1998
3
Astelin nasal spray 18 AZELASTINE HYDROCHLORIDE Wallace Laboratories November 1996
4
Atrovent 18 IPRATROPIUM BROMIDE Boehringer Ingelheim January 1996
5
Clarinex 18 DESLORATADINE Schering-Plough February 2002
6
Claritin RediTabs 18 LORATADINE Schering-Plough January 1997
7
Clemastine fumarate syrup 18 CLEMASTINE FUMARATE Morton Grove Pharmaceuticals March 1998
8
Dymista 18 AZELASTINE HYDROCHLORIDE; FLUTICASONE PROPIONATE Meda Pharmaceuticals Inc May 2012
9
Flonase Nasal Spray 18 FLUTICASONE PROPIONATE GlaxoSmithKline November 1997
10
Grastek 18 Timothy Grass Pollen Allergen Extract Merck April 2014
11
Nasacort AQ Nasal Spray 18 TRIAMCINOLONE ACETONIDE Phone-Poulenc Rorer October 1997
12
Oralair 18 Greer Labs April 2014
13
Patanase 18 OLOPATADINE HYDROCHLORIDE Alcon April 2008
14
Qnasl 18 BECLOMETHASONE DIPROPIONATE Teva Pharmaceutical March 2012
15
Ragwitek 18 Merck April 2014
16
Rhinocort Aqua Nasal Spray 18 BUDESONIDE AstraZeneca October 1999
17
Tri-Nasal Spray 18 Muro Pharmaceutical February 2000
18
Xyzal 18 LEVOCETIRIZINE DIHYDROCHLORIDE UCB May 2007
19
Zyrtec 18 CETIRIZINE HYDROCHLORIDE Pfizer December 1995

Drugs for Allergic Rhinitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 325)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 75614-87-8, 51-45-6 774
2
Capsaicin Approved Phase 4 404-86-4 1548943
3
Cetirizine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83881-51-0 2678
4
Montelukast Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 158966-92-8 5281040
5
Nitric Oxide Approved Phase 4,Not Applicable 10102-43-9 145068 160954
6
Azelastine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58581-89-8 2267
7
Fluticasone Approved, Experimental, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 90566-53-3 62924
8
Levocetirizine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 130018-77-8 1549000
9
Ephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 299-42-3 9294
10
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
11
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
12
Pseudoephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 90-82-4 7028
13
Xylometazoline Approved, Investigational Phase 4 526-36-3 5709
14
Desloratadine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 100643-71-8 124087
15
Loratadine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 79794-75-5 3957
16
Oxymetazoline Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1491-59-4 4636
17
Phenylephrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59-42-7 6041
18
Betamethasone Approved, Vet_approved Phase 4,Phase 3 378-44-9 9782
19
Omalizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 242138-07-4
20
Ciclesonide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 126544-47-6, 141845-82-1 444033
21
Budesonide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51333-22-3 63006 5281004
22
Fexofenadine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 83799-24-0 3348
23
Adenosine Approved, Investigational Phase 4,Phase 2,Phase 1 58-61-7 60961
24
Doxazosin Approved Phase 4 74191-85-8 3157
25
Triamcinolone Approved, Vet_approved Phase 4,Phase 3 124-94-7 31307
26
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 1 51-43-4 5816
27
Racepinephrine Approved Phase 4,Phase 3,Phase 1 329-65-7 838
28
Diphenhydramine Approved, Investigational Phase 4,Phase 1 147-24-0, 58-73-1 3100
29
Promethazine Approved, Investigational Phase 4,Phase 1 60-87-7 4927
30
Tranilast Approved, Investigational Phase 4 53902-12-8 93543
31
Prazosin Approved Phase 4 19216-56-9 4893
32
Theophylline Approved Phase 4,Phase 2 58-55-9 2153
33
Almotriptan Approved, Investigational Phase 4 154323-57-6, 181183-52-8 123606
34
Resveratrol Approved, Experimental, Investigational Phase 4,Phase 3 501-36-0 445154
35
Pimecrolimus Approved, Investigational Phase 4 137071-32-0 6447131 17753757
36
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
37
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 2,Phase 3 50-14-6 5280793
38
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3 1406-16-2
39
Vitamin D3 Approved, Nutraceutical Phase 4,Phase 2,Phase 3 67-97-0 6221 5280795
40 Histamine Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
41 Histamine H1 Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
42
Histamine Phosphate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-74-1 65513
43 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
44 Antipruritics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
45 Dermatologic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
47 Anti-Allergic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
48 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
49 Histamine H1 Antagonists, Non-Sedating Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
50 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 898)
# Name Status NCT ID Phase Drugs
1 Immunological Mechanisms of Oralair® in Patients With Seasonal Allergic Rhinitis Unknown status NCT02014623 Phase 4 Control
2 Assessment of Sublingual Immunotherapy in Children Allergic to House Dust Mites Unknown status NCT01052610 Phase 4 sublingual house dust mites allergen extract;placebo in sublingual applicator
3 Comparative Study of Sinol and Sinol-M in Patients With Congestion Due to Allergic Rhinitis Unknown status NCT00825656 Phase 4 Sinol or Sinol-M nasal spray
4 Comparison of the Effect of Montelukast and Cetirizine on Allergic Inflammation in Children With Allergic Rhinitis Unknown status NCT00488176 Phase 4 montelukast;cetirizine;montelukast and cetirizine;placebo
5 Evaluating Factors Involved in Dymista's Superior Clinical Efficacy to Fluticasone Propionate in the Treatment of Seasonal Allergic Rhinitis Unknown status NCT02402465 Phase 4 Placebo;Fluticasone propionate;Fluticasone/Azelastine nasal spray
6 AZELASTINE/FLUTICASONE (AZE/FLU) Nasal Spray on Symptom Control, Nasal Mediators and Nasal Hyperresponsiveness in Allergic Rhinitis (AR) Unknown status NCT02238353 Phase 4 azelastine + fluticasone;Placebo
7 Efficacy of Allergen Immunotherapy for Allergic Rhinitis in Thais Unknown status NCT01115595 Phase 4
8 Cosalin® Monotherapy Versus Cosalin® and Xarlin® Combination Therapy Unknown status NCT01062139 Phase 4 Xarlin (Levocetirizine);Cosalin (Petasites hybridus CO2 extract)
9 4"S" - Seasonal Symptoms Suppression Study Unknown status NCT02557269 Phase 4 Xylometazoline - intranasal application;Azelastine - intranasal application;Mometasone furoate - intranasal application;Hydroxyl-propyl-methyl cellulose powder - intranasal application;Bilastine 20 mg;Prednisolone 5 mg
10 Elaboration of Patient-friendly Treatment Strategy With Capsaicin Nasal Spray in Patients With Idiopathic Rhinitis Unknown status NCT02288156 Phase 4 Capsaicin;placebo
11 Anti-inflammatory H1 Antihistamines Allergic Rhinitis Completed NCT02507635 Phase 4 Levocetirizine;Desloratadine
12 Sunovion Growth Study Pediatric Subjects With Mild Asthma & Allergic Rhinitis Completed NCT01550471 Phase 4 Alvesco/Omnaris, QVAR/Beconase, Placebo/Placebo;Alvesco/Omnaris, Placebo/Placebo, QVAR/Beconase;QVAR/Beconase, Alvesco/Omnaris, Placebo/Placebo;QVAR/Beconase, Placebo/Placebo, Alvesco/Omnaris;Placebo/Placebo, Alvesco/Omnaris, QVAR/Beconase;Placebo/Placebo, QVAR/Beconase, Alvesco/Omnaris
13 Quality of Life in Patients With Allergic Rhinitis: Clinical Trial With Bilastine or Loratadine Completed NCT02513290 Phase 4 Bilastine;Loratadine
14 Comparison of Effectiveness and Safety of Sublingual Immunotherapy in Children With Allergic Rhinitis Completed NCT00698594 Phase 4
15 Nasal Budesonide Efficacy on Nasal FeNO in Children With Allergic Rhinitis Completed NCT02409563 Phase 4 Budesonide nasal spray (100 mcg bid);Budesonide nasal spray (50 mcg bid
16 Montelukast and Fexofenadine Versus Montelukast and Levocetrizine Combination in Allergic Rhinitis Completed NCT02551536 Phase 4 Montelukast;Fexofenadine;Levocetrizine
17 Efficacy and Safety of Lectranal® in Treatment of Seasonal Allergic Rhinitis Symptoms Completed NCT00460538 Phase 4
18 Nebulized Beclometasone Dipropionate Improves Nasal Patency in Children With Allergic Rhinitis Completed NCT02646904 Phase 4 Nasal Beclomethasone Dipropionate;CERCHIO 10 mg/ml OS
19 Effectiveness Of Therapy With A Thermal Water Nasal Aerosol In Children With Seasonal Allergic Rhinitis Completed NCT01326247 Phase 4
20 Comparison of Olopatadine 0.6% and Fluticasone Proprionate 50mcg Nasal Sprays in a Two Week Seasonal Allergic Rhinitis Trial Completed NCT00691665 Phase 4 Olopatadine HCL Nasal Spray, 0.6%;Fluticasone Propionate Nasal Spray, 50 mcg
21 Montelukast in Mild Asthmatic Children With Allergic Rhinitis (0476-367) Completed NCT00442559 Phase 4 montelukast sodium;inhaled corticosteroid
22 Levocetirizine 5 mg: Reduction of Symptoms, Airway Resistance and Sleep Impairment in Persistent Allergic Rhinitis Completed NCT00355771 Phase 4 Levocetirizine;Placebo
23 To Evaluate Adenosine Monophosphate and Allergen Challenge in Allergic Rhinitis Completed NCT00679250 Phase 4 levocetirizine;placebo to levocetirizine
24 POPULAR (Preference Of Patient Using Levocetirizine in Allergic Rhinitis) Completed NCT00160537 Phase 4 Levocetirizine
25 Comparison of the Effects of Nasal Steroids and Montelukast on Olfactory Functions in Patients With Allergic Rhinitis Completed NCT02565212 Phase 4 Montelukast,mometazon froat
26 Effects of Hypertonic Saline Solution (NACL 3%+NAHCO3) on Nasal Inflammation in Children With AR. RinASol- Pilot Study Completed NCT02729012 Phase 4 hypertonic saline solution (NACL 3%+NAHCO3)
27 Fluticasone and Salmeterol in Allergic Rhinitis Completed NCT01388595 Phase 4 FLUTICASONE PROPRIONATE;Salmeterol;PLACEBO
28 Alpha-Blockers in Allergic Rhinitis (MAN 01) Completed NCT01946035 Phase 4 Doxazosin XL
29 Children, Perennial Allergic Rhinitis (PAR), l-t Growth Completed NCT00641212 Phase 4 Budesonide;Placebo
30 Efficacy and Tolerability of a Topical Microemulsion in Patients With Allergic Rhinitis Due to Sensitization to Pollen Completed NCT01478425 Phase 4
31 A Study Evaluating the Efficacy and Impact on Health-related Quality of Life of Levocetirizine in Adults With Seasonal Allergic Rhinitis Completed NCT00653224 Phase 4 levocetirizine dihydrochloride;placebo
32 A Study Evaluating the Efficacy and Impact on Health-related Quality of Life of Levocetirizine in Adults With Seasonal Allergic Rhinitis Completed NCT00621959 Phase 4 levocetirizine dihydrochloride;placebo
33 Safety of PATANASE Nasal Spray in Patients With Perennial Allergic Rhinitis Completed NCT00789555 Phase 4 Olopatadine hydrochloride 0.6% nasal spray (PATANASE)
34 Levocetirizine Effect on Nasal Nitric Oxide and Nasal Eosinophils in Subjects With Perennial Allergic Rhinitis Completed NCT00894231 Phase 4 levocetirizine (Xyzal);placebo
35 Single-Center, Double-Blind, Randomized , Parallel Study Comparing Onset of Action, Efficacy & Safety of a Single-Dose of Fexofenadine HCl 180 mg vs Montelukast Na 10 mg & Placebo in Treating Seasonal Allergic Rhinitis Subjects in an Allergen Exposure Uni Completed NCT00637611 Phase 4 Fexofenadine HCl
36 Fluticasone Furoate Treatment of Daytime Somnolence and Cognitive Performance in Seasonal Allergic Rhinitis Completed NCT00997620 Phase 4 Fluticasone furoate Nasal Spray 110 mcg;Placebo
37 Allergic Rhinitis Changes the Sinus Microbiome Completed NCT01852513 Phase 4 QNASL;Placebo nasal spray
38 A Randomized, Placebo Controlled Study to Determine the Efficacy and Speed of a Nasal Spray in Allergen Induced Seasonal Allergic Rhinitis Completed NCT00561717 Phase 4 Azelastine and placebo;Loratadine and Placebo;Cetirizine and Placebo;Placebo and Placebo (spray and Tablet)
39 A Clinical Study To Test A Nasal Spray (Fluticasone Furoate Nasal Spray) For The Treatment Of Perennial (Year-round) Allergic Rhinitis Completed NCT00609674 Phase 4 Fluticasone furoate nasal spray;Placebo
40 Safety of Astepro 0.15% Nasal Spray and Astepro 0.1% Nasal Spray in Children Ages >6 Months to <6 Years With AR Completed NCT01880840 Phase 4 205.5 mcg of azelastine hydrochloride;137 mcg of azelastine hydrochloride
41 Study of Bronchodilation Effects of Cetirizine Completed NCT01781507 Phase 4 Cetirizine;Placebo
42 Efficacy & Safety of Loratadine-Betamethasone Oral Solution for Treatment of Severe Perennial Allergic Rhinitis in Children (Study P03428) Completed NCT00963573 Phase 4 Loratadine;Betamethasone
43 Onset of Effect of Mometasone Nasal Spray in Induced Allergic Rhinitis (Study P03431) Completed NCT00783237 Phase 4 Mometasone;Placebo
44 Assessment of Intranasal Steroids in Allergic Rhinitis When Used Alone or in Combination With an Oral Antihistamine (Study P03270) Completed NCT00834119 Phase 4 Mometasone furoate;Mometasone furoate
45 A 6 Month Safety Study Of Ciclesonide Nasal Aerosol (Zetonna®) And Ciclesonide Nasal Spray (Omnaris®) In Subjects 12 Years And Older With Perennial Allergic Rhinitis (PAR) Completed NCT01654536 Phase 4 ciclesonide nasal aerosol;ciclesonide nasal spray
46 Study of Triamcinolone Acetonide on the Growth Velocity of Children, Ages 3 to 9, With Perennial Allergic Rhinitis (PAR) Completed NCT00449072 Phase 4 TAA-AQ, Nasacort® AQ;Claritin®
47 Efficacy and Safety of Desloratadine vs. Fexofenadine 180 mg. vs. Placebo for Treating Seasonal Allergic Rhinitis (SAR) (Study P04054) Completed NCT00783146 Phase 4 desloratadine;fexofenadine;placebo
48 Efficacy and Safety of Desloratadine vs. Fexofenadine 180 mg. vs. Placebo for Treating Seasonal Allergic Rhinitis (SAR)(Study P04053)(COMPLETED) Completed NCT00783211 Phase 4 desloratadine;fexofenadine;placebo
49 Singulair(R) In Asthma And Allergic Rhinitis (0476-383) Completed NCT00545844 Phase 4 montelukast sodium
50 Comparison of the Effects of Desloratadine and Placebo in the Relief of Nasal Symptom Scores in Subjects With Seasonal Allergic Rhinitis to Cypress Pollen (Study P02836) Completed NCT00867191 Phase 4 Placebo;Desloratadine

Search NIH Clinical Center for Allergic Rhinitis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: rhinitis, allergic, seasonal

Genetic Tests for Allergic Rhinitis

Genetic tests related to Allergic Rhinitis:

# Genetic test Affiliating Genes
1 Allergic Rhinitis 29 IL13

Anatomical Context for Allergic Rhinitis

MalaCards organs/tissues related to Allergic Rhinitis:

41
Testes, Eye, Skin, Neutrophil, T Cells, Pituitary, Lung

Publications for Allergic Rhinitis

Articles related to Allergic Rhinitis:

(show top 50) (show all 1894)
# Title Authors Year
1
Glucocorticoid-Induced Transcription Factor 1 (GLCCI1) Variant Impacts the Short-Term Response to Intranasal Corticosteroids in Chinese Han Patients with Seasonal Allergic Rhinitis. ( 29981236 )
2018
2
Local allergic rhinitis: Implications for management. ( 29900607 )
2018
3
SOCS3 Is Upregulated and Targeted by miR30a-5p in Allergic Rhinitis. ( 29471302 )
2018
4
Basophils from allergic rhinitis patients show allergen-specific upregulation of thymic stromal lymphopoietin receptor. ( 29413340 )
2018
5
Induced pluripotent stem cell-derived mesenchymal stem cells activate quiescent T cells and elevate regulatory T cell response via NF-I_B in allergic rhinitis patients. ( 29921316 )
2018
6
A Randomized, Multicenter, Double-blind, Phase III Study to Evaluate the Efficacy on Allergic Rhinitis and Safety of a Combination Therapy of Montelukast and Levocetirizine in Patients With Asthma and Allergic Rhinitis. ( 29945738 )
2018
7
Reply to the letter to the author concerning: 'Does adenoid hypertrophy affect disease severity in children with allergic rhinitis?' ( 29423746 )
2018
8
Impact of acupuncture on antihistamine use in patients suffering seasonal allergic rhinitis: secondary analysis of results from a randomised controlled trial. ( 29440045 )
2018
9
Efficacy of indoor air purification in treating Artemisia (mugwort) pollen allergic rhinitis: study protocol for a randomised controlled trial. ( 29976165 )
2018
10
Effects of anti-allergic drugs on T cell-mediated nasal hyperresponsiveness in a murine model of allergic rhinitis. ( 29910099 )
2018
11
The International Study of the Allergic Rhinitis Survey: outcomes from 4 geographical regions. ( 29423374 )
2018
12
Occupational allergic rhinitis and contact urticaria caused by Gum Arabic in a candy factory worker. ( 29446105 )
2018
13
Economic Burden of the Inadequate Management of Allergic Rhinitis and Urticaria in Asian Countries Based on the GAA^LEN Model. ( 29949833 )
2018
14
Allergic rhinitis management: what's next? ( 29406839 )
2018
15
Cold weather increases respiratory symptoms and functional disability especially among patients with asthma and allergic rhinitis. ( 29973669 )
2018
16
Comparison of Specific Immunoglobulin E with the Skin Prick Test in the Diagnosis of House Dust Mites and Cockroach Sensitization in Patients with Asthma and/or Allergic Rhinitis. ( 29950531 )
2018
17
Validation of the Children's Sleep Habits Questionnaire in a sample of Greek children with allergic rhinitis. ( 29338964 )
2018
18
Correlation between upper and lower airway inflammations in patients with combined allergic rhinitis and asthma syndrome: A comparison of patients initially presenting with allergic rhinitis and those initially presenting with asthma. ( 29434763 )
2018
19
Evaluation of allergic rhinitis with nasal symptoms and nasal mucociliary clearance in patients with fibromyalgia syndrome. ( 29889054 )
2018
20
Changes in basophil activation during immunotherapy with house dust mite and mugwort in patients with allergic rhinitis. ( 29423373 )
2018
21
The use of specific immunoglobulin E in nasal secretions for the diagnosis of allergic rhinitis. ( 29417583 )
2018
22
Radiological comparison of inferior turbinate hypertrophy between allergic and non-allergic rhinitis: does allergy really augment turbinate hypertrophy? ( 29417277 )
2018
23
Distinct Gene Expression Patterns between Nasal Mucosal Cells and Blood Collected from Allergic Rhinitis Sufferers. ( 29920501 )
2018
24
Long-term efficacy of standardised specific subcutaneous immunotherapy in children with persistent allergic rhinitis due to multiple allergens including house dust mites. ( 29374499 )
2018
25
Onset of action for loratadine tablets for the symptomatic control of seasonal allergic rhinitis in adults challenged with ragweed pollen in the Environmental Exposure Unit: a post hoc analysis of total symptom score. ( 29371864 )
2018
26
International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis. ( 29438602 )
2018
27
Otolaryngologist adherence to the AAO-HNSF Allergic Rhinitis Clinical Practice Guideline. ( 29412510 )
2018
28
Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis. ( 29949830 )
2018
29
Use of the Control of Allergic Rhinitis and Asthma Test and pulmonary function tests to assess asthma control in pregnancy. ( 28749014 )
2018
30
Repeatability of nasal allergen challenge results - further validation of the allergic rhinitis clinical investigator collaborative (AR-CIC) protocols. ( 29432965 )
2018
31
Pattern of allergic rhinitis among children in Ekiti, Nigeria. ( 29447897 )
2018
32
Cypress pollen allergy is responsible for two distinct phenotypes of allergic rhinitis different from other pollinosis. ( 29350019 )
2018
33
Effects of H1 antihistamine addition to intranasal corticosteroid for allergic rhinitis: a systematic review and meta-analysis. ( 29917324 )
2018
34
Isolation and profiling of plasma microRNAs: Biomarkers for Asthma and Allergic Rhinitis. ( 29906503 )
2018
35
International consensus statement on allergy and rhinology: allergic rhinitis-executive summary. ( 29438600 )
2018
36
Responsiveness of Nasal Provocation Testing-But Not Skin Test and Specific Immunoglobulin E Blood Level-Correlates With Severity of Allergic Rhinitis in Dermatophagoides Species-Sensitized Patients. ( 29909644 )
2018
37
The control of allergic rhinitis in real life: a multicenter cross-sectional Italian study. ( 29434524 )
2018
38
Association between allergic rhinitis and poor sleep parameters in U.S. adults. ( 29979840 )
2018
39
Smell loss is associated with severe and uncontrolled disease in children and adolescents with persistent allergic rhinitis. ( 29426750 )
2018
40
The Iron Chelator and Anticancer Agent Dp44mT Relieves Allergic Inflammation in Mice With Allergic Rhinitis. ( 29967928 )
2018
41
Saline irrigation for allergic rhinitis. ( 29932206 )
2018
42
Dysbiosis of inferior turbinate microbiota is associated with high total IgE levels in allergic rhinitis patients. ( 29426044 )
2018
43
Eating fish and farm life reduce allergic rhinitis at the age of twelve. ( 29446153 )
2018
44
Anti-inflammatory effect of wogonin on allergic responses in ovalbumin-induced allergic rhinitis in the mouse. ( 29977652 )
2018
45
Benefits of Nasal Cellulose Powder Application Depend on the Type of Allergen Sensitization in Allergic Rhinitis. ( 29411560 )
2018
46
Against NF-I_B/thymic stromal lymphopoietin signaling pathway, catechin alleviates the inflammation in allergic rhinitis. ( 29894863 )
2018
47
The pharmacotherapy preferred by doctors in treatment of patients diagnosed with asthma or chronic obstructive pulmonary disease or allergic rhinitis and concomitant diseases: an epidemiological analysis. ( 28507495 )
2017
48
The Allergic Rhinitis and its Impact on Asthma (ARIA) score of allergic rhinitis using mobile technology correlates with quality of life: The MASK study. ( 28906011 )
2017
49
Mesenchymal stromal cells ameliorate acute allergic rhinitis in rats. ( 28940415 )
2017
50
&amp;quot;Allergic mood&amp;quot; - Depressive and anxiety symptoms in patients with seasonal allergic rhinitis (SAR) and their association to inflammatory, endocrine, and allergic markers. ( 28495610 )
2017

Variations for Allergic Rhinitis

ClinVar genetic disease variations for Allergic Rhinitis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 IL13 NM_002188.2(IL13): c.431A> G (p.Gln144Arg) single nucleotide variant risk factor rs20541 GRCh37 Chromosome 5, 131995964: 131995964
2 IL13 NM_002188.2(IL13): c.431A> G (p.Gln144Arg) single nucleotide variant risk factor rs20541 GRCh38 Chromosome 5, 132660272: 132660272

Expression for Allergic Rhinitis

LifeMap Discovery
Genes differentially expressed in tissues of Allergic Rhinitis patients vs. healthy controls: 35
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 CST1 cystatin SN Respiratory System + 6.00 0.000
Search GEO for disease gene expression data for Allergic Rhinitis.

Pathways for Allergic Rhinitis

Pathways related to Allergic Rhinitis according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.93 ALOX5 CCL11 CXCL8 EPX ICAM1 IGHE
2
Show member pathways
13.62 ALOX5 CCL11 CXCL8 IL13 IL18 IL4
3
Show member pathways
13.45 CCL11 CXCL8 IL13 IL18 IL4 IL4R
4
Show member pathways
13.35 CCL11 CXCL8 IL13 IL18 IL4 IL4R
5
Show member pathways
13.29 ALOX5 CCL11 CXCL8 ICAM1 IGHE IL13
6
Show member pathways
13.23 CCL11 CXCL8 IL13 IL18 IL4 IL4R
7
Show member pathways
12.83 CCL11 HRH1 IGHE IL4 IL4R
8 12.76 CXCL8 IL13 IL4 IL4R IL5
9
Show member pathways
12.72 CXCL8 ICAM1 IL13 IL18 IL4
10
Show member pathways
12.58 CXCL8 IL13 IL18 IL4 IL4R IL5
11
Show member pathways
12.53 ALOX5 IGHE IL13 IL4 IL5 MS4A2
12
Show member pathways
12.44 CCL11 CXCL8 EPX ICAM1 IL13 IL18
13
Show member pathways