ALRH
MCID: ALL003
MIFTS: 66

Allergic Rhinitis (ALRH)

Categories: Genetic diseases, Immune diseases, Respiratory diseases

Aliases & Classifications for Allergic Rhinitis

MalaCards integrated aliases for Allergic Rhinitis:

Name: Allergic Rhinitis 57 12 72 36 29 54 15 39 17 70
Hay Fever 12 42 15 62 70
Allergic Rhinitis, Susceptibility to 57 13 6
Rhinitis, Allergic, Perennial 44 17 70
Seasonal Allergic Rhinitis 12 17
Atopic Rhinitis 12 70
Alrh 57 72
Non-Seasonal Allergic Rhinitis 12
Rhinitis, Allergic, Seasonal 44
Perenial Allergic Rhinitis 12
Rhinitis Allergic Seasonal 54
Pollenosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4481
OMIM® 57 607154
KEGG 36 H01360
NCIt 50 C34987
SNOMED-CT 67 38103000
ICD10 32 J30.1 J30.4
MedGen 41 C2607914
UMLS 70 C0002103 C0018621 C0035457 more

Summaries for Allergic Rhinitis

MedlinePlus : 42 Each spring, summer, and fall, trees, weeds, and grasses release tiny pollen grains into the air. Some of the pollen ends up in your nose and throat. This can trigger a type of allergy called hay fever. Symptoms can include Sneezing, often with a runny or clogged nose Coughing and postnasal drip Itching eyes, nose and throat Red and watery eyes Dark circles under the eyes Your health care provider may diagnose hay fever based on a physical exam and your symptoms. Sometimes skin or blood tests are used. Taking medicines and using nasal sprays can relieve symptoms. You can also rinse out your nose, but be sure to use distilled or sterilized water with saline. Allergy shots can help make you less sensitive to pollen and provide long-term relief.

MalaCards based summary : Allergic Rhinitis, also known as hay fever, is related to pollen allergy and giant papillary conjunctivitis, and has symptoms including tinnitus, rhinorrhea and snoring. An important gene associated with Allergic Rhinitis is IL13 (Interleukin 13), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Xylometazoline and Cetirizine have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and eye, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 A rhinitis that is an allergic inflammation and irritation of the nasal airways involving sneezing, runny nose, nasal congestion, itching and tearing of the eyes caused by exposure to an allergen such as pollen, dust, mold, animal dander and droppings of cockroaches or house dust mites.

KEGG : 36 Allergic rhinitis (AR) is an inflammation of nasal mucosa mediated by IgE-associated processes, which is characterised by pruritus, sneezing, rhinorrhoea, and nasal congestion. The development of AR entails a complex interaction between genetic predisposition and environmental exposure to different factors, of which the most important is the implicated allergen. Single-nucleotide polymorphism studies involving genes encoding for molecules implicated in the pathogenesis of AR have also been made. Such molecules comprise chemokines and their receptors, interleukins and their receptors, eosinophil peroxidase and leukotrienes, among others.

UniProtKB/Swiss-Prot : 72 Allergic rhinitis: A common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure.

PubMed Health : 62 About hay fever: Many children and adults are affected by hay fever in the spring and summer months, when plants grow and bloom. Sneezing and itchy eyes can be a real problem, especially on days that are warm and dry. A lot of people who have allergies and asthma have more asthma attacks around this time of year too. Hay fever is an allergic reaction to pollen in the air, affecting the upper airways. The symptoms it causes are called allergic rhinitis.

Wikipedia : 73 Allergic rhinitis, also known as hay fever, is a type of inflammation in the nose which occurs when the... more...

More information from OMIM: 607154

Related Diseases for Allergic Rhinitis

Diseases related to Allergic Rhinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 622)
# Related Disease Score Top Affiliating Genes
1 pollen allergy 32.4 RNASE3 MPO IL5 IL4R IL13 IGHE
2 giant papillary conjunctivitis 32.2 RNASE3 IL4 CXCL8 CCL11
3 ige responsiveness, atopic 32.2 RNASE3 IL5 IL4R IL4 IL13 IL10
4 churg-strauss syndrome 32.0 RNASE3 MPO IL5 IL10 CXCL8 CCL11
5 cytokine deficiency 31.9 IL5 IL13
6 rhinitis 31.8 VIP RNASE3 NGF KNG1 IL5 IL4R
7 allergic asthma 31.6 RNASE3 IL5 IL4R IL4 IL13 IL10
8 chronic rhinitis 31.6 RNASE3 MPO IL5 IL4 IL13 HRH1
9 respiratory allergy 31.6 RNASE3 IL5 IL4R IL4 IL13 IL10
10 sleep apnea 31.5 IL10 ICAM1 CXCL8
11 vasomotor rhinitis 31.4 VIP RNASE3 KNG1 IL5 IL13
12 chronic urticaria 31.4 RNASE3 IL4 IL13 IGHE HRH1
13 urticaria 31.4 RNASE3 IL5 IL4 IL13 IL10 IGHE
14 dermatitis 31.3 RNASE3 IL5 IL4R IL4 IL13 IL10
15 exanthem 31.3 IL10 IFNG CXCL8
16 conjunctivitis 31.3 RNASE3 MPO IL5 IL4 IL13 IL10
17 dermatitis, atopic 31.3 VIP RNASE3 NGF IL5 IL4R IL4
18 allergic disease 31.2 RNASE3 MPO IL5 IL4R IL4 IL13
19 otitis media 31.2 RNASE3 MPO IL5 IL4 IL10 IGHE
20 hypereosinophilic syndrome 31.2 RNASE3 MPO IL5 IL4 IL13 IGHE
21 allergic conjunctivitis 31.1 RNASE3 IL5 IL4 IL13 IL10 IGHE
22 acute asthma 31.1 RNASE3 IL5 IL4 ALOX5
23 exercise-induced bronchoconstriction 31.0 RNASE3 IL13 ALOX5
24 common cold 31.0 RNASE3 IL5 IL4 IL13 IL10 ICAM1
25 thyroiditis 31.0 IL4 IL10 IFNG
26 drug allergy 30.9 IL5 IL4R IL13 IGHE
27 periodontitis 30.9 IL4 IL10 IFNG CXCL8
28 fibromyalgia 30.9 NGF IL10 CXCL8
29 food allergy 30.9 RNASE3 IL5 IL4R IL4 IL13 IL10
30 tonsillitis 30.9 MPO IL4 IL10 IFNG CXCL8
31 cough variant asthma 30.8 RNASE3 NGF IL5 IL4 IGHE
32 gastroesophageal reflux 30.8 VIP MPO IL5 IL4 CXCL8 CCL11
33 graves' disease 30.8 MPO IL4 IL13 IFNG ICAM1
34 candidiasis 30.8 IL4 IL10 IFNG CXCL8
35 chronic asthma 30.8 RNASE3 IL5 IL4 IL13 IGHE CCL11
36 hashimoto thyroiditis 30.8 IL4 IL10 IFNG ICAM1
37 esophagitis, eosinophilic, 1 30.8 RNASE3 IL5 IL4 IL13 EPX CCL11
38 pulmonary disease, chronic obstructive 30.7 RNASE3 MPO IL5 IL4 IL13 IL10
39 migraine with or without aura 1 30.7 VIP NGF KNG1 IL10
40 toxic shock syndrome 30.7 IL4 IL10 IFNG CXCL8
41 bronchitis 30.7 VIP RNASE3 MPO IL5 IL4 IL13
42 proteasome-associated autoinflammatory syndrome 1 30.7 RNASE3 MPO IL5 IL4 IL13 IL10
43 aspergillosis 30.7 IL5 IL4 IL10 IFNG EPX CXCL8
44 intrinsic asthma 30.6 RNASE3 IL5 IL4 IL13 IGHE
45 esophagitis 30.6 RNASE3 IL5 IL4 IL13 IL10 CXCL8
46 irritable bowel syndrome 30.6 VIP NGF IL4 IL10 CXCL8
47 smallpox 30.6 IL4 IFNG ICAM1
48 sarcoidosis 1 30.6 IL13 IFNG ICAM1 CCL11
49 chronic fatigue syndrome 30.6 IL5 IL4 IL13 IL10 IFNG CXCL8
50 tetanus 30.5 IL5 IL4 IL13 IL10 IFNG

Comorbidity relations with Allergic Rhinitis via Phenotypic Disease Network (PDN):


Anxiety Bronchitis
Esophagitis Hypertension, Essential
Hypothyroidism

Graphical network of the top 20 diseases related to Allergic Rhinitis:



Diseases related to Allergic Rhinitis

Symptoms & Phenotypes for Allergic Rhinitis

Clinical features from OMIM®:

607154 (Updated 05-Apr-2021)

UMLS symptoms related to Allergic Rhinitis:


tinnitus; rhinorrhea; snoring; sore throat; coughing; vertigo/dizziness; equilibration disorder

MGI Mouse Phenotypes related to Allergic Rhinitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.03 ALOX5 CCL11 EPX HRH1 ICAM1 IFNG
2 homeostasis/metabolism MP:0005376 10 ALOX5 EPX HRH1 ICAM1 IFNG IL10
3 digestive/alimentary MP:0005381 9.92 FOXJ1 ICAM1 IFNG IL10 IL13 IL4
4 immune system MP:0005387 9.77 ALOX5 CCL11 EPX HRH1 ICAM1 IFNG
5 respiratory system MP:0005388 9.28 CCL11 FOXJ1 IFNG IL10 IL13 IL4

Drugs & Therapeutics for Allergic Rhinitis

PubMed Health treatment related to Allergic Rhinitis: 62

Various medications are available to treat the symptoms: Antihistamines Steroids (corticosteroids) Chromones (mast cell stabilizers) Leukotriene receptor antagonists Decongestant nasal drops and sprays There are also non-drug alternatives such as saline (salt water) nasal sprays and nasal washes (nasal irrigation). Allergen -specific immunotherapy (also known as desensitization) can reduce your sensitivity to allergens over the long term. Like with vaccines, this treatment approach involves being exposed to small amounts of the substance by having it injected or placing it under your tongue . In allergen-specific immunotherapy, you are exposed to the allergen at regular intervals. The treatment takes about three years to complete.

Drugs for Allergic Rhinitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 227)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Xylometazoline Approved, Investigational Phase 4 526-36-3 5709
2
Cetirizine Approved Phase 4 83881-51-0 2678
3
Loratadine Approved, Investigational Phase 4 79794-75-5 3957
4
Nitric Oxide Approved Phase 4 10102-43-9 145068
5
mometasone furoate Approved, Investigational, Vet_approved Phase 4 83919-23-7
6
Fexofenadine Approved, Investigational Phase 4 83799-24-0 3348
7
Terfenadine Approved, Withdrawn Phase 4 50679-08-8 5405
8
Budesonide Approved Phase 4 51333-22-3 63006 5281004
9
Levocetirizine Approved Phase 4 130018-77-8 1549000
10
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
11
Adenosine Approved, Investigational Phase 4 58-61-7 60961
12
Prazosin Approved Phase 4 19216-56-9 4893
13
Calcium carbonate Approved, Investigational Phase 4 471-34-1
14
Desloratadine Approved, Investigational Phase 4 100643-71-8 124087
15
Promethazine Approved, Investigational Phase 4 60-87-7 4927
16
Diphenhydramine Approved, Investigational Phase 4 58-73-1, 147-24-0 3100
17
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
18
Capsaicin Approved Phase 4 404-86-4 1548943
19
Doxazosin Approved Phase 4 74191-85-8 3157
20
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
21
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
22
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
23
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
24
Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
25
Montelukast Approved Phase 4 158966-92-8 5281040
26
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
27
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 5280795 6221
28
Resveratrol Investigational Phase 4 501-36-0 445154
29
Tranilast Investigational Phase 4 53902-12-8 93543
30
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
31 Purple Butterbur Phase 4
32 Immunologic Factors Phase 4
33
Ethylene Phase 4 74-85-1 6325
34 Pharmaceutical Solutions Phase 4
35
Beclomethasone Phase 4 4419-39-0 20469
36 Triamcinolone diacetate Phase 4
37 triamcinolone acetonide Phase 4
38 Triamcinolone hexacetonide Phase 4
39 Adrenergic alpha-1 Receptor Antagonists Phase 4
40 Adrenergic alpha-Antagonists Phase 4
41 Adrenergic Antagonists Phase 4
42 Antihypertensive Agents Phase 4
43 Trace Elements Phase 4
44 Nutrients Phase 4
45 Calciferol Phase 4
46 Micronutrients Phase 4
47 Calcium, Dietary Phase 4
48 Antioxidants Phase 4
49 Ophthalmic Solutions Phase 4
50 Cholinergic Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 868)
# Name Status NCT ID Phase Drugs
1 Comparison of the Effect of Montelukast and Cetirizine on Allergic Inflammation Measured by Exhaled Nitric Oxide Concentration in Children With Seasonal Allergic Rhinitis Unknown status NCT00488176 Phase 4 montelukast;cetirizine;montelukast and cetirizine;placebo
2 Assessment of Effectiveness and Safety of Annual Sublingual Immunotherapy in Children With Bronchial Asthma and/or Allergic Rhinitis Allergic to House Dust Mites Unknown status NCT01052610 Phase 4 sublingual house dust mites allergen extract;placebo in sublingual applicator
3 Real Life Proof-of-Concept Study to Assess the Effect of Methylcellulose as add-on "Seal" to the In-season Pharmacologic Rescue Treatment in Subjects With Allergic Rhinitis Unknown status NCT02557269 Phase 4 Xylometazoline - intranasal application;Azelastine - intranasal application;Mometasone furoate - intranasal application;Hydroxyl-propyl-methyl cellulose powder - intranasal application;Bilastine 20 mg;Prednisolone 5 mg
4 Evaluating Factors Involved in Dymista's Superior Clinical Efficacy to Fluticasone Propionate in the Treatment of Seasonal Allergic Rhinitis Unknown status NCT02402465 Phase 4 Placebo;Fluticasone propionate;Fluticasone/Azelastine nasal spray
5 Changes in Exhaled Breath Temperature During the Pollen Season in Subjects With Allergic Rhinoconjunctivitis Sensitized to Grasses and Effect of Sublingual Immunotherapy Unknown status NCT01785394 Phase 4 5 grass allergen extract
6 A Randomized, Parallel, Double-blind, Multi-center, Comparative Study to Exploratively Evaluate the Efficacy and Safety of Cosalin® Monotherapy vs. Cosalin® and Xarlin® Combination Therapy in Patients With Allergic Rhinitis Unknown status NCT01062139 Phase 4 Xarlin (Levocetirizine);Cosalin (Petasites hybridus CO2 extract)
7 AZE/FLU Nasal Spray on Symptom Control, Nasal Mediators and Nasal Hyperresponsiveness in Allergic Rhinitis (AR) Unknown status NCT02238353 Phase 4 azelastine + fluticasone;Placebo
8 The Evaluation of Singulair for the Treatment of Non-Allergic Rhinitis Eosinophil Syndrome (NARES) Unknown status NCT00406094 Phase 4 montelukast;placebo
9 The Effect of Cetirizine on Bronchoconstriction in Patients With Allergic Rhinitis and Wheezing in the Pediatric Emergency Department Unknown status NCT03340740 Phase 4 Cetirizine Hydrochloride 1 MG/ML;Placebo - Concentrate
10 SINOL + MucoAd™ (SMAN) Evaluation Trial: A Double-Blind, Cross-Over Comparison of SINOL and SMAN in Subjects With Congestion Due to Allergic Rhinitis Unknown status NCT00825656 Phase 4 Sinol or Sinol-M nasal spray
11 Randomized, Double Blind, Parallel Group, Placebo Controlled, Multi-Center Study of the Efficacy and Safety of Zyrtec® (Cetirizine HCl) Syrup vs. Claritin® (Loratadine) Syrup vs. Placebo in Treatment of Children With Seasonal Allergic Rhinitis (SAR) Completed NCT02932774 Phase 4 Cetirizine;Loratadine
12 Study 200165, A Randomized, Double-Blind, Placebo-Controlled, Multi-Center, Parallel-Group Study to Compare the Efficacy of a 2-Week Treatment With Fluticasone Propionate Nasal Spray Versus Cetirizine in Adult Subjects With Seasonal Allergic Rhinitis (SAR) Completed NCT01916226 Phase 4 FPNS;FPNS Placebo;Cetirizine;Cetirizine Placebo
13 A Comparison of Fluticasone Furoate Nasal Spray Versus Oral Fexofenadine in the Treatment of Seasonal Allergic Rhinitis Completed NCT00435461 Phase 4 Fluticasone furoate and fexofenadine
14 A Comparison of Fluticasone Furoate Nasal Spray Versus Oral Fexofenadine in the Treatment of Seasonal Allergic Rhinitis Completed NCT00502775 Phase 4 fluticasone furoate, fexofenadine
15 A Randomised Double-blind Clinical Trial for Evaluation of Efficacy and Safety of Perennial in Comparison to Preseasonal Grass/Rye Pollen Immunotherapy in Patients Suffering From Seasonal Allergic Rhinitis Completed NCT01555736 Phase 4 grass (80%) and rye (20%) pollens allergoids
16 Regulatory Lymphocytes (Treg) in the Modulation of Allergic Inflammation in Patients Treated With Specific Immunotherapy. Completed NCT01475188 Phase 4 Allergovit
17 A Randomized, Double-blind, Placebo-controlled, Active Comparator, One-Week, Cross-Over, Multicenter Study to Evaluate the Efficacy and Patient Preference of Nasal Spray Characteristics of Once-Daily, Intranasal Administration of 110mcg Fluticasone Furoate Nasal Spray and 200mcg Fluticasone Propionate Nasal Spray in Adult Subjects With Seasonal Allergic Rhinitis Completed NCT00539006 Phase 4 FPNS;FFNS;placebo FPNS;placebo FFNS
18 A Randomized, Double-blind, Placebo-controlled, Active Comparator, One-Week, Cross-Over, Multicenter Study to Evaluate the Efficacy and Patient Preference of Nasal Spray Characteristics of Once-Daily, Intranasal Administration of 110mcg Fluticasone Furoate Nasal Spray and 200mcg Fluticasone Propionate Nasal Spray in Adult Subjects With Seasonal Allergic Rhinitis Completed NCT00519636 Phase 4 FPNS;FFNS;placebo FFNS;placebo FPNS
19 A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multi-Center Study to Evaluate the Effects of a One-Year Course of Fluticasone Furoate Nasal Spray 110mcg QD on Growth in Pre-Pubescent, Pediatric Subjects With Perennial Allergic Rhinitis Completed NCT00570492 Phase 4 Fluticasone furoate nasal spray;Placebo nasal spray
20 A Randomised, Double Blind, Placebo Controlled, 4 Period, Incomplete Block, Crossover Study to Assess the Dose-response Curve of Intranasal Fluticasone Propionate (25, 50, 100 and 200 μg, Once Daily for 8 Days) in the Vienna Challenge Chamber for the Purpose of Investigating the Sensitivity Completed NCT00848965 Phase 4 Fluticasone propionate;Placebo
21 Placebo Controlled Pilot Study on the Efficacy of Levocetirizine 5 mg in Reducing Symptoms, Airway Resistance, and Sleep Impairment in Patients With Persistent Allergic Rhinitis Completed NCT00355771 Phase 4 Levocetirizine;Placebo
22 A Proof of Concept Study to Evaluate Differential Tachyphylaxis of Alpha 1 and Alpha 2 Adrenoreceptor Mediated Decongestant Response to Oxymetazoline and Its Acute Reversal by Corticosteroid in Healthy Volunteers Completed NCT00487032 Phase 4 Oxymetazoline 0.05% w/v;Fluticasone propionate 50 micrograms per actuation;Prazosin hydrochloride;Placebo to Prazosin
23 STUDIO IN DOPPIO CIECO DISODIOCROMOGLICATO + PLACEBO vs DISODIOCROMOGLICATO + IMMUNOTERAPIA SPECIFICA SUBLINGUALE PER ALTERNARIA IN PAZIENTI CON RINITE ALLERGICA DOVUTA A SENSIBILIZZAZIONE AD ALTERNARIA Completed NCT01127035 Phase 4
24 A Multi-center, Open, Randomized, Three-arm, Parallel-group, Phase IV Study to Compare the Efficacy of Ciclesonide Nasal Spray and Levocetirizine, Alone and in Combination for the Patient With Allergic Rhinitis Completed NCT01430260 Phase 4 Ciclesonide;Levocetirizine;Ciclesonide & Levocetirizine
25 Quality of Life in Patients With Allergic Rhinitis: a Clinical Trial Comparing the Use of Bilastine Versus Loratadine Completed NCT02513290 Phase 4 Bilastine;Loratadine
26 Istanbul Gaziosmanpasa Taksim Research and Training Hospital, Completed NCT02565212 Phase 4 Montelukast,mometazon froat
27 A Placebo Controlled Trial to Evaluate The Effects of Levocetirizine on Nasal Allergen Challenge And Adenosine Monophosphate Challenge In Patients With Intermittent and Persistent Allergic Rhinitis Completed NCT00679250 Phase 4 levocetirizine;placebo to levocetirizine
28 Preference Evaluation of Clarinex Tablets vs. Zyrtec Tablets in Subjects With Symptomatic Allergic Rhinitis Completed NCT00794846 Phase 4 Desloratadine 5 mg (Clarinex);Cetirizine (Zyrtec)
29 Preference Evaluation of Clarinex Tablets vs. Zyrtec Tablets in Subjects With Symptomatic Allergic Rhinitis Completed NCT00794495 Phase 4 Desloratadine 5 mg (Clarinex);Cetirizine (Zyrtec)
30 Preference Evaluation of Clarinex Tablets vs. Zyrtec Tablets in Subjects With Symptomatic Allergic Rhinitis Completed NCT00794599 Phase 4 Desloratadine 5 mg (Clarinex);Cetirizine (Zyrtec)
31 Double-blind, Three Parallel Randomized Groups, Therapeutic Confirmatory Clinical Trial to Compare the Efficacy of Oral Levocetirizine 5 mg and Montelukast 10 mg to Placebo in Reducing Symptoms of Seasonal Allergic Rhinitis (SAR) in Ragweed Sensitive Subjects Exposed to Ragweed Pollen in an Environmental Exposure Unit (EEU) Completed NCT00295022 Phase 4 Placebo;Montelukast;Levocetirizine
32 A Multi-center, Open-label, Non-comparative Study of the Relief of Nasal Symptoms and Tolerability in Subjects With Seasonal Allergic Rhinitis (SAR) Treated With Aerius. Completed NCT00805584 Phase 4 desloratadine
33 Trial to Compare the Efficacy and Safety of Levocetirizine 5 mg od and Fexofenadine 120 mg od in Reducing Symptoms of Seasonal Allergic Rhinitis in Grass Pollen Sensitized Adults Completed NCT00542607 Phase 4 levocetirizine dihydrochloride
34 Allergic Rhinitis Changes the Sinus Microbiome Completed NCT01852513 Phase 4 QNASL;Placebo nasal spray
35 A Double-Blind, Placebo-Controlled, Randomized, Parallel-Group Study Using Subjective and Objective Measures to Evaluate the Clinical Efficacy of Mometasone Furoate Nasal Spray (MFNS) Following Initial and Maintenance Dosing in Subjects With Allergen-Induced Seasonal Allergic Rhinitis (SAR) in an Environmental Exposure Chamber (EEC) Completed NCT00491504 Phase 4 Mometasone Furoate Nasal Spray
36 A Double-Blind, Placebo-Controlled, Randomized, Parallel-Group Multicenter Study of Mometasone Furoate Nasal Spray on Sleep Disturbances and Daytime Somnolence in Subjects With Symptomatic Seasonal Allergic Rhinitis Completed NCT00358527 Phase 4 Mometasone Furoate Nasal Spray (MFNS)
37 Clinical Trial to Assess Onset of Action of Azelastine Hydrochloride and Fluticasone Propionate Nasal Spray Delivered in a Single Spray (MP-AzeFlu) in the Treatment of Allergen-Induced Allergic Rhinitis Symptoms in Comparison to Placebo and Free Combination of Fluticasone Propionate Nasal Spray and Oral Loratadine Completed NCT03004131 Phase 4 Azelastine hydrochloride + fluticasone propionate nasal spray;Placebos;fluticasone propionate nasal spray + loratadine
38 Efficacy and Safety of Lectranal® in Treatment of Seasonal Allergic Rhinitis Symptoms Completed NCT00460538 Phase 4
39 A Monocenter, Double-blind, Randomized Trial, With Two Parallel Groups Comparing the Clinical Efficacy of Levocetirizine 5 mg Capsules and Desloratadine 5 mg Capsules Taken Once a Day Over 3 Weeks of Treatment in Adult Subjects Suffering From Seasonal Allergic Rhinitis (SAR) Due to Grass Pollen Completed NCT00160537 Phase 4 Levocetirizine
40 The Addition of Vitamin D to Fluticasone Propionate in the Management of Seasonal Allergic Rhinitis Completed NCT01103934 Phase 4 Vitamin D3;Placebo;Fluticasone Propionate
41 A Multi-center, Randomized, Double-blind, Placebo-controlled, Parallel-group Study Evaluating the Efficacy and Impact on Health-related Quality of Life of Levocetirizine 5 mg Once Daily Given for 2 Weeks in Subjects 18 yr of Age and Older With Seasonal Allergic Rhinitis Completed NCT00621959 Phase 4 levocetirizine dihydrochloride;placebo
42 A Four-Way Double-Blind, Randomized, Placebo Controlled Study to Determine the Efficacy and Speed of Azelastine Nasal Spray and Antihistaminic Agents in Adult Subjects With Allergen Induced Seasonal Allergic Rhinitis Completed NCT00561717 Phase 4 Azelastine and placebo;Loratadine and Placebo;Cetirizine and Placebo;Placebo and Placebo (spray and Tablet)
43 A Placebo Controlled Study of the Efficacy and Safety of Desloratadine vs. Fexofenadine 180 mg. in the Treatment of Subjects With Symptomatic Seasonal Allergic Rhinitis (SAR) Completed NCT00783211 Phase 4 desloratadine;fexofenadine;placebo
44 A Placebo Controlled Study of the Efficacy and Safety of Desloratadine vs. Fexofenadine 180 mg. in the Treatment of Subjects With Symptomatic Seasonal Allergic Rhinitis (SAR) Completed NCT00783146 Phase 4 desloratadine;fexofenadine;placebo
45 Preference Evaluation of Clarinex Tablets vs. Allegra Tablets in Subjects With Symptomatic Seasonal Allergic Rhinitis Completed NCT00783133 Phase 4 Desloratadine 5 mg;fexofenadine
46 A Double-masked, Randomized, Parallel Group, Comparison of Olopatadine 0.6% and Fluticasone Proprionate 50mcg Nasal Sprays in a Two Week Seasonal Allergic Rhinitis Trial Completed NCT00691665 Phase 4 Olopatadine HCL Nasal Spray, 0.6%;Fluticasone Propionate Nasal Spray, 50 mcg
47 A Multi-Centre, Double-Blind, Randomised Comparison Of The Effects Of Desloratadine (Aerius®) And Placebo In The Relief Of Nasal Symptom Scores In Subjects With Seasonal Allergic Rhinitis (Sar) To Cypress Pollen Completed NCT00867191 Phase 4 Placebo;Desloratadine
48 A Double Blind, Placebo Controlled Randomized Trial Evaluating the Effects of Fluticasone Nasal Spray in Subjects With Seasonal Allergic Rhinitis and a History of Sleep Disturbance on Cognitive Performance and Daytime Sleepiness Completed NCT00997620 Phase 4 Fluticasone furoate Nasal Spray 110 mcg;Placebo
49 Preference Evaluation of Clarinex Tablets vs. Allegra Tablets in Subjects With Symptomatic Seasonal Allergic Rhinitis Completed NCT00794248 Phase 4 desloratadine 5 mg;fexofenadine
50 Single-Center, Double-Blind, Randomized , Parallel Study Comparing Onset of Action, Efficacy & Safety of a Single-Dose of Fexofenadine HCl 180 mg vs Montelukast Na 10 mg & Placebo in Treating Seasonal Allergic Rhinitis Subjects in an Allergen Exposure Unit (Study I) Completed NCT00637611 Phase 4 Fexofenadine HCl

Search NIH Clinical Center for Allergic Rhinitis

Inferred drug relations via UMLS 70 / NDF-RT 51 :


acrivastine
Astemizole
azatadine
Azatadine maleate
azelastine
Azelastine hydrochloride
Beclomethasone
Beclomethasone Dipropionate
bromodiphenhydramine
Bromodiphenhydramine hydrochloride
Brompheniramine
Brompheniramine Maleate
Budesonide
carbinoxamine
Carbinoxamine maleate
Cetirizine
cetirizine hydrochloride
chlorcyclizine
Chlorcyclizine hydrochloride
CHLOROTHEN MALEATE
Chlorpheniramine
Chlorpheniramine Maleate
CHLORPHENIRAMINE POLISTIREX
Chlorpheniramine Tannate
Clemastine
Clemastine Fumarate
Cromolyn
Cromolyn Sodium
Cyproheptadine
Cyproheptadine hydrochloride
CYPROHEPTADINE HYDROCHLORIDE MONOHYDRATE
desloratadine
Dexamethasone
dexamethasone acetate
DEXAMETHASONE ACETATE PWDR
Dexamethasone phosphate
Dexamethasone sodium phosphate
DEXAMETHASONE SODIUM PHOSPHATE PWDR
dexbrompheniramine
Dexbrompheniramine maleate
dexchlorpheniramine
Dexchlorpheniramine maleate
Diphenhydramine
Diphenhydramine Citrate
Diphenhydramine Hydrochloride
Doxylamine
doxylamine succinate
fexofenadine
Fexofenadine hydrochloride
flunisolide
fluticasone
fluticasone furoate
Fluticasone propionate
Guaifenesin
Ipratropium
Ipratropium Bromide
levocetirizine
levocetirizine dihydrochloride
Loratadine
Methapyrilene
METHAPYRILENE HYDROCHLORIDE
methdilazine
Methdilazine hydrochloride
Mometasone
mometasone furoate
Mometasone furoate monohydrate
montelukast
montelukast sodium
phenindamine
Phenindamine tartrate
Pheniramine
Pheniramine Maleate
Phenylpropanolamine Hydrochloride
phenyltoloxamine
Phenyltoloxamine citrate
PHENYLTOLOXAMINE RESIN COMPLEX
Promethazine
PROMETHAZINE HYDROBROMIDE
Promethazine Hydrochloride
Pseudoephedrine
Pseudoephedrine Hydrochloride
Pseudoephedrine sulfate
Pyrilamine
Pyrilamine Maleate
PYRILAMINE TANNATE
Triamcinolone
Triamcinolone Acetonide
TRIAMCINOLONE ACETONIDE PWDR
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Cochrane evidence based reviews: rhinitis, allergic, seasonal

Genetic Tests for Allergic Rhinitis

Genetic tests related to Allergic Rhinitis:

# Genetic test Affiliating Genes
1 Allergic Rhinitis 29 IL13

Anatomical Context for Allergic Rhinitis

MalaCards organs/tissues related to Allergic Rhinitis:

40
Skin, T Cells, Eye, Pituitary, Neutrophil, B Cells, Endothelial

Publications for Allergic Rhinitis

Articles related to Allergic Rhinitis:

(show top 50) (show all 20541)
# Title Authors PMID Year
1
A common IL-13 Arg130Gln single nucleotide polymorphism among Chinese atopy patients with allergic rhinitis. 61 6 57
12928861 2003
2
Identification of single nucleotide polymorphisms in FOXJ1 and their association with allergic rhinitis. 61 57
16518568 2006
3
Allergic rhinitis--a total genome-scan for susceptibility genes suggests a locus on chromosome 4q24-q27. 57 61
11840197 2001
4
Measuring Temporal Instability of Momentary Affect, Subjective Health and Symptom Burden Depending on Environmental Parameters-An Ambulatory Assessment Study in Persons with Hay Fever. 42 61
33419198 2021
5
A new portable sampler to monitor pollen at street level in the environment of patients. 61 42
32887011 2020
6
Inventory of the Recommendations for Patients with Pollen Allergies and Evaluation of Their Scientific Relevance. 61 42
32911472 2020
7
Highly significant linkage to chromosome 3q13.31 for rhinitis and related allergic diseases. 57
16525028 2006
8
IL-13 R130Q, a common variant associated with allergy and asthma, enhances effector mechanisms essential for human allergic inflammation. 6
15711639 2005
9
Interleukin-13 gene polymorphisms confer the susceptibility of Japanese populations to Graves' disease. 6
15483090 2005
10
Functional effect of the R110Q IL13 genetic variant alone and in combination with IL4RA genetic variants. 6
15356556 2004
11
Genetic variants of IL-13 signalling and human asthma and atopy. 6
10699178 2000
12
Opposing roles of IL-17A and IL-25 in the regulation of TSLP production in human nasal epithelial cells. 61 54
19968632 2010
13
Identification of polymorphisms in the RNase3 gene and the association with allergic rhinitis. 61 54
19760211 2010
14
[The expression of interleukin-17 in blood and nasal tissue of patients with allergic rhinltis and nasal polyps]. 54 61
20506642 2010
15
Identification of polymorphisms in the Toll-like receptor gene and the association with allergic rhinitis. 61 54
19763595 2010
16
Local allergic rhinitis: a new entity, characterization and further studies. 61 54
20010094 2010
17
CLC- a novel susceptibility gene for allergic rhinitis? 61 54
19650845 2010
18
Effects of a dual CCR3 and H1-antagonist on symptoms and eosinophilic inflammation in allergic rhinitis. 54 61
20144207 2010
19
The role of neurotrophins in the pathophysiology of allergic rhinitis. 54 61
19935061 2010
20
Peripheral Th-17 cells in allergic rhinitis: New evidence. 54 61
19925886 2010
21
Sensory neuropeptides are potent chemoattractants for human basophils in vitro. 54 61
20035805 2010
22
High-level expression of early growth response-1 and association of polymorphism with total IgE and atopy in allergic rhinitis adults. 61 54
19833116 2010
23
Association of the CD14 gene polymorphism C-159T with allergic rhinitis. 54 61
20109306 2010
24
[The expression and significance of interleukin-17 and the infiltrating eosinophils in nasal polyps and nasal mucous of allergic rhinitis]. 54 61
20306850 2010
25
Association between TIM-1 gene polymorphisms and allergic rhinitis in a Han Chinese population. 61 54
20232767 2010
26
Relationship between squamous cell carcinoma antigen and the clinical severity of allergic rhinitis caused by Dermatophagoides farinae and Japanese cedar pollen. 54 61
20128182 2010
27
[Expression of CD23 and CD19 on peripheral blood lymphocytes and its association with serum total IgE in patients with allergic rhinitis]. 54 61
20359104 2009
28
[Serum ECP levels in patients with allergic rhinitis and chronic rhinosinusitis.]. 61 54
20193614 2009
29
Interleukin 17 and RANTES levels in induced sputum of patients with allergic rhinitis after a single nasal allergen challenge. 54 61
19927541 2009
30
Nasal inflammatory mediators and specific IgE production after nasal challenge with grass pollen in local allergic rhinitis. 54 61
19796796 2009
31
Is serum total IgE levels a good predictor of allergies in children? 61 54
19813686 2009
32
[The expression of mucins gene in the human nasal polyps and allergic rhinitis]. 61 54
20128280 2009
33
Sublingual immunotherapy affects specific antibody and TGF-beta serum levels in patients with allergic rhinitis. 61 54
20074473 2009
34
TGF-beta and IL-17 serum levels and specific immunotherapy. 61 54
19622397 2009
35
Serum interleukin-17 levels are related to clinical severity in allergic rhinitis. 54 61
19226302 2009
36
Contribution of functional variation in the IL13 gene to allergy, hay fever and asthma in the NSHD longitudinal 1946 birth cohort. 61 54
19254294 2009
37
Emedastine difumarate: a review of its potential ameliorating effect for tissue remodeling in allergic diseases. 61 54
19558341 2009
38
Immunoglobulin production pattern is allergen-specific in polysensitized patients. 61 54
19822071 2009
39
[Expression and significance of VCAM-1 in subjects with allergic inflammation of respiratory tract]. 61 54
19771922 2009
40
Syk: a novel target for treatment of inflammation in lung disease. 61 54
19530990 2009
41
Localized immunoglobulin E expression in allergic rhinitis and nasal polyposis. 61 54
19417663 2009
42
Glucocorticoid receptor immunoreactivity of eosinophils in nasal polyps. 61 54
19848249 2009
43
Nasal endothelial interleukin-10 expression is negatively correlated with nasal symptoms after allergen provocation. 61 54
19383027 2009
44
TRPV1-mediated itch in seasonal allergic rhinitis. 54 61
19220220 2009
45
Serum eosinophil granule proteins predict asthma risk in allergic rhinitis. 61 54
19133919 2009
46
[The investigation for the neuropeptides of nasal septum in perennial allergic rhinitis patient]. 61 54
19685709 2009
47
Association of single nucleotide polymorphisms in GATA-3 with allergic rhinitis. 54 61
18607915 2009
48
[Experimental research on the relationship between GATA-3 and ICAM-1 in patients with allergic rhinitis]. 54 61
19452711 2009
49
Anti-IgE for the treatment of allergic rhinitis--and eventually nasal polyps? 54 61
18799888 2009
50
Effects of Clara cell 10 (CC10) protein on symptoms and signs of allergic rhinitis. 54 61
19205286 2009

Variations for Allergic Rhinitis

ClinVar genetic disease variations for Allergic Rhinitis:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 IL13 NM_002188.3(IL13):c.431A>G (p.Gln144Arg) SNV risk factor 14673 rs20541 GRCh37: 5:131995964-131995964
GRCh38: 5:132660272-132660272

Expression for Allergic Rhinitis

LifeMap Discovery
Genes differentially expressed in tissues of Allergic Rhinitis patients vs. healthy controls: 35
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 CST1 cystatin SN Respiratory System + 6.00 0.000
Search GEO for disease gene expression data for Allergic Rhinitis.

Pathways for Allergic Rhinitis

Pathways related to Allergic Rhinitis according to GeneCards Suite gene sharing:

(show all 44)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.03 RNASE3 MPO IL5 IL4R IL4 IL13
2
Show member pathways
13.69 NGF IL5 IL4R IL4 IL13 IL10
3
Show member pathways
13.56 NGF IL5 IL4R IL4 IL13 IL10
4
Show member pathways
13.41 NGF IL5 IL4R IL4 IL13 IL10
5
Show member pathways
13.33 IL5 IL4R IL4 IL13 IL10 IGHE
6
Show member pathways
13.32 NGF IL5 IL4R IL4 IL13 IL10
7 12.87 KNG1 IL5 IL4R IL4 IL13 IFNG
8
Show member pathways
12.64 IL4R IL4 IL10 IGHE IFNG
9
Show member pathways
12.63 IL5 IL4R IL4 IL13 IL10 IFNG
10
Show member pathways
12.6 IL5 IL4 IL13 IGHE ALOX5
11
Show member pathways
12.6 RNASE3 IL5 IL4 IL13 IL10 IFNG
12 12.57 MPO IL4 IL10 IFNG ALOX5
13
Show member pathways
12.46 IL5 IL4R IL4 IL13 IL10 IFNG
14
Show member pathways
12.42 IL4R IL4 IGHE HRH1 CCL11
15
Show member pathways
12.37 MPO IL4 IFNG ICAM1 ALOX5
16
Show member pathways
12.36 IL5 IL4 IL13 IFNG CXCL8 CCL11
17
Show member pathways
12.28 NGF IL5 IL4 IL13 IL10 IFNG
18
Show member pathways
12.26 IL4 IL10 IFNG ALOX5
19
Show member pathways
12.2 IL4 IFNG CXCL8 CCL11
20 12.18 NGF IL13 IL10 CXCL8
21 12.04 MPO IL5 IL4 IL10 IFNG
22 12.03 IL4 IFNG ICAM1 CXCL8
23 11.84 IFNG ICAM1 CXCL8
24
Show member pathways
11.83 IL4R IL4 IFNG
25
Show member pathways
11.81 IL5 IL4 IFNG CXCL8
26 11.81 IL5 IL4 IL13 IL10 IFNG
27 11.79 IL5 IL4 IL13 IFNG ICAM1 CXCL8
28 11.74 IL5 IL4 IL10 ICAM1
29 11.69 IL5 IL4 IL13 CXCL8 CCL11
30
Show member pathways
11.66 IFNG ICAM1 CXCL8
31 11.6 IL10 IFNG ICAM1 CXCL8
32 11.54 IL4 IL13 IL10 ICAM1 CXCL8
33 11.53 MPO KNG1 ICAM1
34 11.53 IL5 IL4R IL4 IL10 IGHE CCL11
35 11.49 IFNG ICAM1 CXCL8
36 11.44 KNG1 IL10 IFNG ICAM1
37 11.38 IL5 IL4R IL4 IFNG
38 11.34 IL5 IL4 IL13 IFNG
39 11.33 IL4R IL4 IL13 IL10 IGHE ICAM1
40 11.23 IL5 IL4 IL13 IL10 IFNG
41 11.16 IL5 IL4R IL4 IL13 IL10 IFNG
42 11.13 IL5 IL4 IL13 IL10 IFNG
43 11.06 NGF IL5 IL4 IL13 IL10 CXCL8
44 10.81 IL5 IL4R IL4 IL13

GO Terms for Allergic Rhinitis

Cellular components related to Allergic Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 VIP RNASE3 NGF MPO KNG1 IL5
2 extracellular space GO:0005615 9.5 RNASE3 NGF MPO KNG1 IL5 IL4R

Biological processes related to Allergic Rhinitis according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 10.03 VIP NGF MPO IL4 IL10
2 positive regulation of gene expression GO:0010628 10.01 NGF IL4 IL13 IFNG CXCL8
3 response to lipopolysaccharide GO:0032496 9.88 MPO IL13 IL10 ICAM1
4 defense response to bacterium GO:0042742 9.85 RNASE3 MPO IL10 IGHE EPX
5 negative regulation of inflammatory response GO:0050728 9.83 IL4 IL13 IL10 ALOX5
6 inflammatory response GO:0006954 9.8 KNG1 IL5 IL13 HRH1 CXCL8 CCL11
7 cellular response to interleukin-1 GO:0071347 9.79 ICAM1 CXCL8 CCL11
8 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.77 IL4 IL13 IFNG
9 positive regulation of endothelial cell proliferation GO:0001938 9.77 VIP IL10 CCL11
10 humoral immune response GO:0006959 9.76 IFNG FOXJ1 ALOX5
11 positive regulation of B cell proliferation GO:0030890 9.71 IL5 IL4 IL13
12 microglial cell activation GO:0001774 9.65 IL4 IL13 IFNG
13 positive regulation of signaling receptor activity GO:2000273 9.63 IL10 IFNG
14 macrophage activation GO:0042116 9.62 IL4 IL13
15 negative regulation of endothelial cell apoptotic process GO:2000352 9.62 IL4 IL13 IL10 ICAM1
16 response to molecule of bacterial origin GO:0002237 9.61 IL10 CXCL8
17 positive regulation of macrophage activation GO:0043032 9.61 IL4R IL13 IL10
18 immune response GO:0006955 9.61 IL5 IL4R IL4 IL13 IL10 IGHE
19 positive regulation of MHC class II biosynthetic process GO:0045348 9.58 IL4 IL10 IFNG
20 positive regulation of cellular respiration GO:1901857 9.57 IL4 IFNG
21 neuroinflammatory response GO:0150076 9.56 IL4 IFNG
22 type 2 immune response GO:0042092 9.55 IL4 IL10
23 positive regulation of mast cell degranulation GO:0043306 9.54 IL4R IL4 IL13
24 negative regulation of complement-dependent cytotoxicity GO:1903660 9.51 IL4 IL13
25 regulation of isotype switching GO:0045191 9.49 IL4 IL10
26 positive regulation of immunoglobulin production GO:0002639 9.46 IL5 IL4R IL13 IL10
27 cytokine-mediated signaling pathway GO:0019221 9.32 IL5 IL4R IL4 IL13 IL10 IGHE

Molecular functions related to Allergic Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.26 NGF IL5 IL4 IL10
2 cytokine activity GO:0005125 9.17 IL5 IL4 IL13 IL10 IFNG CXCL8

Sources for Allergic Rhinitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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