MCID: ALL007
MIFTS: 27

Allergic Urticaria

Categories: Skin diseases, Immune diseases

Aliases & Classifications for Allergic Urticaria

MalaCards integrated aliases for Allergic Urticaria:

Name: Allergic Urticaria 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10612
ICD10 33 L50.0
ICD9CM 35 708.0
UMLS 73 C0149526

Summaries for Allergic Urticaria

MalaCards based summary : Allergic Urticaria is related to hereditary angioedema and angioedema. An important gene associated with Allergic Urticaria is FCER1A (Fc Fragment Of IgE Receptor Ia), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Complement and coagulation cascades. The drugs Acidophilus and Caseins have been mentioned in the context of this disorder. Affiliated tissues include skin.

Related Diseases for Allergic Urticaria

Diseases related to Allergic Urticaria via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 28)
# Related Disease Score Top Affiliating Genes
1 hereditary angioedema 30.0 KNG1 SERPING1
2 angioedema 29.7 KNG1 SERPING1
3 corticosteroid-binding globulin deficiency 10.4 A2M NR3C1
4 c1 inhibitor deficiency 10.4 KNG1 SERPING1
5 nelson syndrome 10.3 CRH NR3C1
6 acth-secreting pituitary adenoma 10.3 CRH NR3C1
7 complement deficiency 10.3 KNG1 SERPING1
8 adrenal cortex disease 10.3 CRH NR3C1
9 adrenal gland disease 10.3 CRH NR3C1
10 urticaria 10.2
11 hydrops, lactic acidosis, and sideroblastic anemia 10.2 KNG1 SERPING1
12 subendocardial myocardial infarction 10.2 A2M SERPINA1
13 epileptic encephalopathy, early infantile, 36 10.2 A2M SERPINA1
14 adrenal gland hyperfunction 10.1 CRH NR3C1
15 malignant essential hypertension 10.1 ENSG00000264813 KNG1
16 byssinosis 10.1 A2M SERPINA1
17 mental depression 10.1 CRH NR3C1
18 post-traumatic stress disorder 10.0 CRH NR3C1
19 fibromyalgia 10.0 CRH SERPINA1
20 chronic fatigue syndrome 10.0 CRH NR3C1
21 tricuspid valve stenosis 9.9 ENSG00000264813 SERPINA1
22 dermatitis, atopic 9.7
23 dermatitis 9.7
24 neurodermatitis 9.7 EHF KNG1
25 urinary system disease 9.7 CRH ENSG00000264813
26 hypertension, essential 9.5 ENSG00000264813 KNG1 NR3C1
27 arteries, anomalies of 9.3 ENSG00000264813 KNG1
28 asthma 9.1 CRH FCER1A KNG1 NR3C1

Comorbidity relations with Allergic Urticaria via Phenotypic Disease Network (PDN):


Acute Cystitis Heart Disease
Hypertension, Essential Intermediate Coronary Syndrome
Ischemic Heart Disease

Graphical network of the top 20 diseases related to Allergic Urticaria:



Diseases related to Allergic Urticaria

Symptoms & Phenotypes for Allergic Urticaria

Drugs & Therapeutics for Allergic Urticaria

Drugs for Allergic Urticaria (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Acidophilus Nutraceutical Phase 2,Not Applicable
2 Caseins Not Applicable
3 Chelating Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Primary Prevention of Allergic Disease in Early Child by Lactobacillus Reuteri Completed NCT01285830 Phase 2
2 Effect Of Lactobacillus GG on Atopic March Unknown status NCT01891916 Not Applicable

Search NIH Clinical Center for Allergic Urticaria

Genetic Tests for Allergic Urticaria

Anatomical Context for Allergic Urticaria

MalaCards organs/tissues related to Allergic Urticaria:

41
Skin

Publications for Allergic Urticaria

Articles related to Allergic Urticaria:

# Title Authors Year
1
Atopic Dermatitis and Allergic Urticaria: Cutaneous Manifestations of Immunodeficiency. ( 27886899 )
2017
2
Allergic urticaria: a case report of rare skin allergy with a common mouthwash. ( 23372227 )
2013
3
Allergic urticaria from tonic water. ( 11991290 )
2002
4
A case of allergic urticaria caused by erythritol. ( 10774141 )
2000
5
Allergic urticaria and angioedema caused by a hemostatic sponge of bovine fibrin used in tooth extraction. ( 8721528 )
1996
6
Cimetidine treatment of recalcitrant acute allergic urticaria. ( 3777596 )
1986
7
Allergic urticaria and hereditary angioedema. Independent association in the same patient. ( 6509770 )
1984
8
Ceruloplasmin acitivity in chronic allergic urticaria. ( 5575638 )
1971
9
Electrocardiographic changes associated with allergic urticaria. ( 14493320 )
1961
10
Conditioned reflex allergic urticaria. ( 14484547 )
1961

Variations for Allergic Urticaria

Expression for Allergic Urticaria

Search GEO for disease gene expression data for Allergic Urticaria.

Pathways for Allergic Urticaria

GO Terms for Allergic Urticaria

Cellular components related to Allergic Urticaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.55 A2M CRH KNG1 SERPINA1 SERPING1
2 blood microparticle GO:0072562 9.13 A2M KNG1 SERPING1
3 platelet alpha granule lumen GO:0031093 8.92 A2M KNG1 SERPINA1 SERPING1

Biological processes related to Allergic Urticaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.58 KNG1 SERPINA1 SERPING1
2 negative regulation of endopeptidase activity GO:0010951 9.56 A2M KNG1 SERPINA1 SERPING1
3 hemostasis GO:0007599 9.54 KNG1 SERPINA1 SERPING1
4 negative regulation of peptidase activity GO:0010466 9.46 A2M KNG1 SERPINA1 SERPING1
5 cellular response to dexamethasone stimulus GO:0071549 9.43 CRH NR3C1
6 negative regulation of complement activation, lectin pathway GO:0001869 9.32 A2M SERPING1
7 platelet degranulation GO:0002576 9.26 A2M KNG1 SERPINA1 SERPING1
8 blood coagulation, intrinsic pathway GO:0007597 8.8 A2M KNG1 SERPING1

Molecular functions related to Allergic Urticaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase inhibitor activity GO:0004866 9.16 A2M KNG1
2 serine-type endopeptidase inhibitor activity GO:0004867 9.13 A2M SERPINA1 SERPING1
3 peptidase inhibitor activity GO:0030414 8.92 A2M KNG1 SERPINA1 SERPING1

Sources for Allergic Urticaria

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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