MCID: ALL007
MIFTS: 32

Allergic Urticaria

Categories: Immune diseases, Skin diseases

Aliases & Classifications for Allergic Urticaria

MalaCards integrated aliases for Allergic Urticaria:

Name: Allergic Urticaria 12 15 17 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:10612
ICD9CM 34 708.0
SNOMED-CT 67 40178009
ICD10 32 L50.0
UMLS 71 C0149526

Summaries for Allergic Urticaria

Disease Ontology : 12 An urticaria that is characterized by erythematous papules and plaques, has symptom pruritis, and has material basis in allergic reaction.

MalaCards based summary : Allergic Urticaria is related to allergic hypersensitivity disease and hereditary angioedema, and has symptoms including pruritis An important gene associated with Allergic Urticaria is MS4A2 (Membrane Spanning 4-Domains A2), and among its related pathways/superpathways is Sphingolipid signaling pathway. The drugs Histamine and Cetirizine have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and b cells.

Wikipedia : 74 Hives, also known as urticaria, is a kind of skin rash with red, raised, itchy bumps. They may also burn... more...

Related Diseases for Allergic Urticaria

Diseases related to Allergic Urticaria via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
# Related Disease Score Top Affiliating Genes
1 allergic hypersensitivity disease 29.5 MS4A2 KNG1 FCER1A
2 hereditary angioedema 29.4 SERPING1 KNG1
3 dermatitis, atopic 28.9 MS4A2 KNG1 FCER1A
4 urticaria 10.5
5 angioedema 10.1
6 dermatographia 10.1 SERPING1 FCER1A
7 c1 inhibitor deficiency 9.9 SERPING1 KNG1
8 immune deficiency disease 9.9
9 exanthem 9.9
10 drug allergy 9.9
11 gastric ulcer 9.9
12 pinguecula 9.9
13 rheumatic fever 9.9
14 dermatitis 9.9
15 contact dermatitis 9.9
16 allergic contact dermatitis 9.9
17 hydrops, lactic acidosis, and sideroblastic anemia 9.9 SERPING1 KNG1
18 physical urticaria 9.7 SERPING1 KNG1 FCER1A
19 allergic rhinitis 9.7 MS4A2 KNG1 FCER1A

Comorbidity relations with Allergic Urticaria via Phenotypic Disease Network (PDN):


Acute Cystitis Heart Disease
Hypertension, Essential Intermediate Coronary Syndrome

Graphical network of the top 20 diseases related to Allergic Urticaria:



Diseases related to Allergic Urticaria

Symptoms & Phenotypes for Allergic Urticaria

Symptoms:

12
  • pruritis

Drugs & Therapeutics for Allergic Urticaria

Drugs for Allergic Urticaria (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 3 51-45-6 774
2
Cetirizine Approved Phase 3 83881-51-0 2678
3
Levocetirizine Approved Phase 3 130018-77-8 1549000
4 Neurotransmitter Agents Phase 3
5 Histamine H1 Antagonists, Non-Sedating Phase 3
6 Histamine H1 Antagonists Phase 3
7
Histamine Phosphate Phase 3 51-74-1 65513
8 Histamine Antagonists Phase 3
9 Anti-Allergic Agents Phase 3
10
Desloratadine Approved, Investigational 100643-71-8 124087
11 Cholinergic Antagonists
12 Cholinergic Agents
13 Vaccines
14 Immunologic Factors

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effects of Bilastine on F1 Simulator Driving Performance in Patients Affected by Allergic Rhinitis and/or Urticaria Completed NCT02576041 Phase 4 Bilastine;Placebo
2 A Multi-Center, Randomized, Double-Blind, Placebo-Controlled Parallel-Group Study of the Safety of Levocetirizine Dihydrochloride Oral Liquid Formulation in Children Aged 6 Months to 11 Months With Symptoms of Allergic Rhinitis or Chronic Urticaria. Completed NCT00628108 Phase 3 Levocetirizine 1.25 mg
3 A Multi-Center, Randomized, Double Blind, Placebo Controlled Parallel Group Study of the Safety of Levocetirizine Dihydrochloride Oral Liquid Formulation b.i.d Dosing in Children Aged 1 to < 6 Years Suffering From Allergic Rhinitis or Chronic Urticaria of Unknown Origin Completed NCT00619801 Phase 3 Levocetirizine;Placebo
4 Effects of GOS/PDX Supplemented Formula in Preventing and Modifying the History of Allergy and Acute Infections in a Population of Infants at Risk of Atopy Completed NCT02116452 Phase 3
5 A Multicentre, International, Adaptive, Open-label, Repeated Administration Pharmacokinetic Study of Bilastine in Children From 2 to <12 Years of Age With Allergic Rhinoconjunctivitis or Chronic Urticaria Completed NCT01081574 Phase 1, Phase 2 Bilastine
6 Non-Interventional Study of the Safe Use of Aerius in Pediatric Patients With Allergic Rhinitis or Chronic Idiopathic Urticaria. Completed NCT00723736 Desloratadine
7 The Prevalence of Animal Allergy and Sensitization to Animal Allergen Among Participants in International Symposium of Korean Association for Laboratory Science and Companion Animal Exhibition Completed NCT03101618
8 A Phase IV Study to Assess the Safety of Menveo Vaccine Being Used by HMO Subjects Aged 11-21 Years of Age Completed NCT01452464
9 Post-licensure Observational Safety Surveillance Study of Quadrivalent Meningococcal ACWY Conjugate Vaccine MenACWY-CRM (Menveo) Vaccination in Children 2 Through 10 Years of Age Completed NCT01452438
10 Real-life Management and Therapeutic Outcome of Patients With Chronic Rhinitis and Chronic Urticaria in Thailand Completed NCT02000648

Search NIH Clinical Center for Allergic Urticaria

Genetic Tests for Allergic Urticaria

Anatomical Context for Allergic Urticaria

MalaCards organs/tissues related to Allergic Urticaria:

40
Skin, Testes, B Cells, Pituitary

Publications for Allergic Urticaria

Articles related to Allergic Urticaria:

(show top 50) (show all 66)
# Title Authors PMID Year
1
Identification of Inpatient Allergic Drug Reactions Using ICD-9-CM Codes. 61
30075337 2019
2
A Case of Allergic Urticaria After Ophthalmic Nepafenac Use. 61
29988879 2018
3
Atopic Dermatitis and Allergic Urticaria: Cutaneous Manifestations of Immunodeficiency. 61
27886899 2017
4
[Omalizumab: Beyond anti-IgE properties]. 61
28189435 2017
5
Treating IgE-mediated diseases via targeting IgE-expressing B cells using an anti-CεmX antibody. 61
27090058 2016
6
[DRUGS-INDUCED URTICARIA AND ANGIOEDEMA]. 61
26619738 2015
7
Cardiac urticaria caused by eucleid allergen. 61
26885121 2015
8
Omalizumab, an anti-immunoglobulin E antibody: state of the art. 61
24532966 2014
9
[A challenge for pediatrician: non allergic urticaria]. 61
24620551 2013
10
[Association between Helicobacter pylori and allergic and non-allergic chronic urticaria]. 61
24912907 2013
11
[Risking the skin for some joints]. 61
23888582 2013
12
Allergic urticaria: a case report of rare skin allergy with a common mouthwash. 61
23372227 2013
13
[Eczema and food allergy--is there a causal relationship?]. 61
24720126 2013
14
Japanese guidelines for diagnosis and treatment of urticaria in comparison with other countries. 61
23093797 2012
15
Early neutral prebiotic oligosaccharide supplementation reduces the incidence of some allergic manifestations in the first 5 years of life. 61
23158515 2012
16
[Anaphylaxis due to chicken meat]. 61
22240229 2012
17
[Epidemiology of allergic diseases]. 61
22359881 2011
18
[Clinical variants of chronic urticaria associated with Helicobacter pylori]. 61
21916230 2011
19
The hidden sense of symptoms: urticaria can be beneficial. 61
20729003 2010
20
Allergy is not the main trigger of urticaria in children referred to the emergency room. 61
20337828 2010
21
Asthma and the prospective risk of anaphylactic shock and other allergy diagnoses in a large integrated health care delivery system. 61
20486326 2010
22
[Allergic and toxic cutaneous reactions to plants]. 61
20469665 2010
23
[Skin manifestations of toxic syndrome due to denatured rapeseed oil]. 61
20038361 2009
24
Early dietary intervention with a mixture of prebiotic oligosaccharides reduces the incidence of allergic manifestations and infections during the first two years of life. 61
18492839 2008
25
Preventive effect of hydrolyzed infant formulas persists until age 6 years: long-term results from the German Infant Nutritional Intervention Study (GINI). 61
18539195 2008
26
Antidepressant-like activity of a Kampo (Japanese herbal) medicine, Koso-san (Xiang-Su-San), and its mode of action via the hypothalamic-pituitary-adrenal axis. 61
16516452 2006
27
Do patients with skin allergies have higher levels of anxiety than patients with allergic respiratory diseases? Results of a large-scale cross-sectional study in a French population. 61
16704645 2006
28
Fexofenadine, an H1-receptor antagonist, partially but rapidly inhibits the itch of contact dermatitis induced by diphenylcyclopropenone in patients with alopecia areata. 61
16556272 2006
29
Correlation among skin prick test, total and specific IgE UniCAP tests in atopic patients from Zagreb, Croatia. 61
15588558 2004
30
[Diarrhea as manifestation of allergic diseases. The difficult search for the allergen]. 61
14963968 2003
31
[Which investigations should be performed in chronic urticaria?]. 61
12843815 2003
32
[Immediate hypersensitivity is rarely implicated in drug induced urticaria]. 61
12746667 2003
33
The effect of hydrolyzed cow's milk formula for allergy prevention in the first year of life: the German Infant Nutritional Intervention Study, a randomized double-blind trial. 61
12642834 2003
34
Dietary recommendations for patients allergic to Anisakis simplex. 61
12464163 2002
35
Urticarial vasculitis. 61
12221865 2002
36
Azithromycin in a triple therapy for H.pylori eradication in active duodenal ulcer. 61
12378634 2002
37
Drug-induced urticaria and angioedema: pathomechanisms and frequencies in a developing country and in developed countries. 61
12037395 2002
38
Allergic urticaria from tonic water. 61
11991290 2002
39
[Occupational health problems in dental practice]. 61
12116907 2002
40
[Immunological aspects of laboratory diagnosis of chronic urticaria]. 61
11393027 2001
41
A case of allergic urticaria caused by erythritol. 61
10774141 2000
42
[Changes in electrocardiogram in cases with allergic urticaria by Encleidae]. 61
12567485 2000
43
Assessment of urticaria and angio-oedema. 61
10444223 1999
44
[Round Table: Immunological urticaria mediated by IgE]. 61
10354014 1999
45
Values of complement, T- and B-lymphocytes and immune complexes in patients with skin allergies. 61
9988897 1998
46
Serum tryptase levels in adverse drug reactions. 61
9404562 1997
47
Allergic urticaria and angioedema caused by a hemostatic sponge of bovine fibrin used in tooth extraction. 61
8721528 1996
48
Serum IgG autoantibodies directed against the alpha chain of Fc epsilon RI: a selective marker and pathogenetic factor for a distinct subset of chronic urticaria patients? 61
8675625 1995
49
Serum manganese superoxide dismutase is a new tumour marker for malignant melanoma. 61
8541726 1995
50
[Delayed-pressure urticaria--analysis of 28 patients]. 61
7571540 1995

Variations for Allergic Urticaria

Expression for Allergic Urticaria

Search GEO for disease gene expression data for Allergic Urticaria.

Pathways for Allergic Urticaria

Pathways related to Allergic Urticaria according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.87 MS4A2 KNG1 FCER1A

GO Terms for Allergic Urticaria

Cellular components related to Allergic Urticaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet alpha granule lumen GO:0031093 8.62 SERPING1 KNG1

Biological processes related to Allergic Urticaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hemostasis GO:0007599 8.96 SERPING1 KNG1
2 blood coagulation, intrinsic pathway GO:0007597 8.62 SERPING1 KNG1

Molecular functions related to Allergic Urticaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 IgE binding GO:0019863 8.62 MS4A2 FCER1A

Sources for Allergic Urticaria

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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