Aliases & Classifications for Alopecia

MalaCards integrated aliases for Alopecia:

Name: Alopecia 38 12 76 29 6 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:987
ICD10 33 L65.9
ICD9CM 35 704.0 704.00
MeSH 44 D000505
NCIt 50 C50575
UMLS 73 C0002170

Summaries for Alopecia

Disease Ontology : 12 A hypotrichosis that is characterized by a loss of hair from the head or body.

MalaCards based summary : Alopecia is related to alopecia universalis congenita and clouston syndrome, and has symptoms including exanthema and pruritus. An important gene associated with Alopecia is HR (HR, Lysine Demethylase And Nuclear Receptor Corepressor), and among its related pathways/superpathways are Adhesion and Cell adhesion_Endothelial cell contacts by junctional mechanisms. The drugs Clobetasol and Acitretin have been mentioned in the context of this disorder. Affiliated tissues include Hair and Hair, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 76 Hair loss, also known as alopecia or baldness, refers to a loss of hair from part of the head or body.... more...

Related Diseases for Alopecia

Diseases in the Alopecia family:

Alopecia, Congenital

Diseases related to Alopecia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 533)
# Related Disease Score Top Affiliating Genes
1 alopecia universalis congenita 34.0 AIRE FOXN1 HR MBTPS2
2 clouston syndrome 32.0 ANTXR1 GJA1 TP63
3 nail disorder, nonsyndromic congenital, 1 31.8 AIRE MBTPS2 TP63
4 hypotrichosis 31.2 CLDN1 DCAF17 GJA1 HR KRT86
5 keratosis 30.0 DSP GJA1 MBTPS2
6 hypohidrosis 29.4 KRT14 TP63
7 alopecia areata 12.5
8 alopecia, androgenetic, 1 12.4
9 alopecia totalis 12.3
10 frontal fibrosing alopecia 12.3
11 alopecia, neurologic defects, and endocrinopathy syndrome 12.2
12 mandibulofacial dysostosis with alopecia 12.2
13 t-cell immunodeficiency, congenital alopecia, and nail dystrophy 12.2
14 central centrifugal cicatricial alopecia 12.2
15 palmoplantar keratoderma and congenital alopecia 2 12.2
16 androgenic alopecia 12.2
17 polyposis, skin pigmentation, alopecia, and fingernail changes 12.1
18 autosomal dominant palmoplantar keratoderma and congenital alopecia 12.1
19 palmoplantar keratoderma and congenital alopecia 1 12.1
20 diffuse alopecia areata 12.1
21 alopecia-contractures-dwarfism-intellectual disability syndrome 12.1
22 ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis 12.1
23 alopecia-contractures-dwarfism mental retardation syndrome 12.1
24 alopecia-mental retardation syndrome 1 12.1
25 alopecia, epilepsy, pyorrhea, mental subnormality 12.0
26 autosomal recessive palmoplantar keratoderma and congenital alopecia 12.0
27 alopecia-intellectual disability syndrome 12.0
28 odonto onycho dysplasia with alopecia 12.0
29 alopecia areata 1 12.0
30 alopecia, congenital 12.0
31 ichthyosis alopecia eclabion ectropion mental retardation 11.9
32 alopecia universalis onychodystrophy vitiligo 11.9
33 alopecia-epilepsy-oligophrenia syndrome of moynahan 11.9
34 woodhouse-sakati syndrome 11.8
35 alopecia universalis congenita, xy gonadal dysgenesis, and laryngomalacia 11.8
36 gapo syndrome 11.8
37 lichen planopilaris 11.8
38 alopecia, psychomotor epilepsy, pyorrhea, and mental subnormality 11.8
39 thumb deformity and alopecia 11.8
40 hypergonadotropic hypogonadism and partial alopecia 11.8
41 alopecia, androgenetic, 2 11.8
42 alopecia-mental retardation syndrome 2 11.8
43 alopecia areata 2 11.8
44 alopecia, androgenetic, 3 11.8
45 alopecia-mental retardation syndrome 3 11.8
46 alopecia intellectual disability syndrome 2 11.8
47 frontonasal dysplasia with alopecia and genital anomaly 11.8
48 alopecia, familial focal 11.7
49 ichthyosis with alopecia, eclabium, ectropion, and mental retardation 11.7
50 alopecia-mental retardation syndrome with convulsions and hypergonadotropic hypogonadism 11.7

Graphical network of the top 20 diseases related to Alopecia:



Diseases related to Alopecia

Symptoms & Phenotypes for Alopecia

UMLS symptoms related to Alopecia:


exanthema, pruritus

GenomeRNAi Phenotypes related to Alopecia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00240-S-1 10.2 GJA1
2 Decreased viability GR00381-A-1 10.2 KRT86
3 Decreased viability GR00402-S-2 10.2 CLDN1 MBTPS2 RBM28 DCAF17 RIN2 DSP
4 Mildly decreased CFP-tsO45G cell surface transport GR00360-A-1 9.77 DCAF17 DSP TP63 EDNRA VDR FOXN1
5 no effect GR00402-S-1 9.62 RBM28 DCAF17 RIN2 DSP TP63 EDNRA

MGI Mouse Phenotypes related to Alopecia:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.35 EDNRA AR AHSG AIRE AUTS2 CLDN1
2 cellular MP:0005384 10.28 DSP ANTXR1 AR AUTS2 TP63 VDR
3 cardiovascular system MP:0005385 10.25 ANTXR1 DSP AR TP63 VDR HTRA1
4 endocrine/exocrine gland MP:0005379 10.19 EDNRA AR AIRE ANTXR1 TP63 VDR
5 craniofacial MP:0005382 10.18 EDNRA AR ANTXR1 DSP VDR TP63
6 mortality/aging MP:0010768 10.18 ANTXR1 DSP AR AUTS2 AIRE CLDN1
7 immune system MP:0005387 10.13 ANTXR1 AR AIRE TP63 VDR KRT14
8 digestive/alimentary MP:0005381 10.11 DSP EDNRA AR AIRE TP63 VDR
9 integument MP:0010771 10.1 EDNRA AR CLDN1 DSP VDR TP63
10 hearing/vestibular/ear MP:0005377 10 EDNRA AHSG VDR GJA1 KRT14 HR
11 muscle MP:0005369 9.92 DSP EDNRA AR AHSG TP63 VDR
12 reproductive system MP:0005389 9.81 ANTXR1 AR AIRE TP63 VDR KRT14
13 neoplasm MP:0002006 9.8 ANTXR1 AR AIRE TP63 KRT14 HR
14 skeleton MP:0005390 9.61 ANTXR1 AHSG AR TP63 VDR HTRA1
15 vision/eye MP:0005391 9.23 AIRE TP63 KRT14 FOXN1 HTRA1 GJA1

Drugs & Therapeutics for Alopecia

Drugs for Alopecia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 471)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clobetasol Approved, Investigational Phase 4,Phase 3 25122-46-7, 25122-41-2 32798 5311051
2
Acitretin Approved Phase 4 55079-83-9 6437841 5284513
3
Methylprednisolone Approved, Vet_approved Phase 4,Not Applicable 83-43-2 6741
4
Prednisolone Approved, Vet_approved Phase 4,Not Applicable 50-24-8 5755
5
Doxorubicin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 23214-92-8 31703
6
Triamcinolone Approved, Vet_approved Phase 4,Phase 2,Not Applicable 124-94-7 31307
7
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-18-0, 6055-19-2 2907
8
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 53-03-2 5865
9
Finasteride Approved Phase 4,Phase 3,Phase 1,Phase 2 98319-26-7 57363
10
Minoxidil Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 38304-91-5 4201
11
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
12
Latanoprost Approved, Investigational Phase 4,Not Applicable 130209-82-4 5282380 5311221
13
Imiquimod Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 99011-02-6 57469
14
Hydroxychloroquine Approved Phase 4 118-42-3 3652
15
Capsaicin Approved Phase 4,Not Applicable 404-86-4 1548943
16
Bimatoprost Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 155206-00-1 5311027
17
Drospirenone Approved Phase 4 67392-87-4 68873
18
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3 50-28-2 5757
19 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 3 979-32-8
20
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
21
Polyestradiol phosphate Approved Phase 4,Phase 3 28014-46-2
22
Benzocaine Approved, Investigational Phase 4,Phase 3 1994-09-7, 94-09-7 2337
23
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 22916-47-8 4189
24
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 1,Phase 2 128794-94-5 5281078
25
Mycophenolic acid Approved Phase 4,Phase 1,Phase 2 24280-93-1 446541
26
Tacrolimus Approved, Investigational Phase 4,Phase 1 104987-11-3 445643 439492
27
Hydroxocobalamin Approved Phase 4 13422-51-0 11953898 44475014
28
Adenosine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 58-61-7 60961
29
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 119141-88-7 4594 9579578
30
Ketoconazole Approved, Investigational Phase 4 65277-42-1 47576 3823
31
Desogestrel Approved Phase 4 54024-22-5 40973
32
Levonorgestrel Approved, Investigational Phase 4,Phase 3 797-63-7, 17489-40-6 13109
33
Spironolactone Approved Phase 4,Phase 2 1952-01-7, 52-01-7 5833
34
Etonogestrel Approved, Investigational Phase 4 54048-10-1 40976 6917715
35
Abatacept Approved Phase 4,Phase 2 332348-12-6 10237
36
Apremilast Approved, Investigational Phase 4,Phase 2,Not Applicable 608141-41-9 11561674
37
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59-30-3 6037
38
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58-05-9 143 6006
39 Orange Approved, Nutraceutical Phase 4,Phase 1,Not Applicable
40 tannic acid Approved, Nutraceutical Phase 4,Phase 3
41
Cyanocobalamin Approved, Nutraceutical Phase 4 68-19-9 44176380
42
Manganese Approved, Nutraceutical Phase 4 7439-96-5 27854
43
Methylcobalamin Approved, Experimental, Investigational, Nutraceutical Phase 4 13422-55-4
44
Doxil Approved June 1999 Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 31703
45 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Dermatologic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
47 Emollients Phase 4
48 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
49 Hormone Antagonists Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
50 Hormones Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 596)
# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Clobetasol Propionate 0.05% E Foam in Alopecia Unknown status NCT01111981 Phase 4 Clobetasol Propionate 0.05% Emollient Foam
2 Low-Dose (17.5 mg/Day) Acitretin: Comparable Efficacy Without the Side Effects? Unknown status NCT01228409 Phase 4 Acitretin 17.5 mg/day
3 Topical 5% Minoxidil and Potent Topical Corticosteroid Versus Intralesional Corticosteroid in the Treatment of Alopecia Areata Completed NCT03535233 Phase 4 Triamcinolone Acetonide;Minoxidil 5 % Topical Spray;clobetasol propionate
4 Comparison of Topical Latanoprost vs Topical Corticosteroid in Treatment of Localized Alopecia Areata Completed NCT02350023 Phase 4 Topical latanoprost 0.005%;Topical betamethasone 0.05%
5 Aldara for the Treatment of Extensive Alopecia Areata Completed NCT00177021 Phase 4 Aldara Cream 5%
6 Characteristics of T Cells From Alopecia Areata Scalp Skin Before and After Treatment With Aldara 5% Completed NCT00176943 Phase 4 Aldara Cream 5%
7 Plaquenil for Alopecia Areata, Alopecia Totalis Completed NCT00176982 Phase 4 Hydroxychloroquine
8 Safety and Efficacy of Oral Mega Pulse Methylprednisolone in Severe Therapy Resistant Alopecia Areata Completed NCT01167946 Phase 4 methylprednisolone sodium succinate;methylprednisolone sodium succinate;methylprednisolone sodium succinate
9 Response of Topical Capsaicin in Alopecia Areata Completed NCT00176969 Phase 4 Capsaicin
10 Safety and Efficacy of Bimatoprost Solution in Treating Eyelash Loss or Hypotrichosis in Children Completed NCT01023841 Phase 4 bimatoprost ophthalmic solution 0.03%;Vehicle Sterile Solution
11 Doxorubicin Pharmacokinetics and Response in Non Hodgkin's Lymphoma Completed NCT00969462 Phase 4 Doxorubicin
12 Clinical, Metabolic and Endocrine Effects of the Treatment With Drospirenone and Ethinyl Estradiol Alone or in Combination With Myo-inositol in Young Women With Polycystic Ovary Syndrome (PCOS) and Insulin Resistance Completed NCT01511822 Phase 4 Drospirenone Ethinyl estradiol;Drospirenone Ethinyl estradiol Myo-inositol;placebo
13 PRO With Luxerm® in the Field Treatment of Thin and Non-hyperkeratotic Non-pigmented AK Completed NCT03511326 Phase 4 Methyl Aminolaevulinate 16% Cream
14 Topical Imiquimod Cream in Combination With Cryotherapy for the Treatment of Actinic Keratoses Completed NCT00774787 Phase 4 imiquimod 5% cream
15 The Vienna Prograf and Endothelial Progenitor Cell Study Completed NCT00182559 Phase 4 Ciclosporin;Tacrolimus
16 Myo-inositol Versus D-chiro-inositol in the Treatment of Polycystic Ovary Syndrome and Insulin Resistance: Evaluation of Clinical, Metabolic, Endocrine and Ultrasound Parameters Completed NCT01514942 Phase 4 Folic acid, vit B12;Folic acid, vit B12
17 VEG113971: An Open-Label Study of the Effects of Ketoconazole or Esomeprazole on Pazopanib PK Completed NCT01205230 Phase 4 pazopanib
18 A Phase 4, Placebo-Controlled, Randomized Study to Evaluate the Immunogenicity and Safety of HPV and Tdap When Administered With MenACWY in Adolescents Completed NCT01424644 Phase 4
19 Apremilast in the Treatment of Central Centrifugal Cicatricial Alopecia (CCCA) Recruiting NCT03521687 Phase 4 Apremilast
20 Intralesional Steroids in the Treatment of Alopecia Areata Recruiting NCT01898806 Phase 4 Intralesional Triamcinolone 2.5 mg/ml;Intralesional Triamcinolone 5 mg/ml;Intralesional Triamcinolone 10 mg/ml;Intralesional Saline
21 Adipose Derived Stem Cells Versus Platelet Rich Plasma on Follicular Unit Extraction Recruiting NCT03388840 Phase 4
22 Acceptability & Tolerance of Immediate Versus Delayed Postpartum Contraceptive Implant Recruiting NCT03353012 Phase 4 Etonogestrel Drug Implant;Levonorgestrel Drug Implant
23 PAINTER: Polymorphism And INcidence of Toxicity in ERibulin Treatment Recruiting NCT02864030 Phase 4 ERIBULIN MESYLATE
24 Abatacept in Juvenile Dermatomyositis Recruiting NCT02594735 Phase 4 Abatacept
25 Comparing Different Platelet Rich Plasma (PRP) Treatment Regimens for Management of Androgenic Alopecia Active, not recruiting NCT02999737 Phase 4
26 Extended Follow-up of Treatment of Prednisone Plus Cyclophosphamide in Patients With Advanced-stage IgA Nephropathy Active, not recruiting NCT03218852 Phase 4 prednisone and cyclophosphamide;prednisone alone
27 Treatment of Prednisone Plus Cyclophosphamide in Patients With Advanced-stage IgA Nephropathy Active, not recruiting NCT01758120 Phase 4 prednisone plus cyclophosphamide;Prednisone alone
28 Trial Evaluating the Efficacy of Apremilast for the Treatment of Frontal Fibrosing Alopecia Not yet recruiting NCT03422640 Phase 4 Apremilast
29 Cryotherapy Versus Steroids In Alopecia Areata:Trichoscopic Evaluation Not yet recruiting NCT03473600 Phase 4 Triamcinolone acetonide injection
30 The Use of 5mg Finasteride Versus 200mg Spironolactone and Topical 5% Minoxidil in Treating Postmenopausal Female Androgenetic Alopecia Withdrawn NCT02483195 Phase 4 5% Minoxidil;200mg Spironolactone;5mg Finasteride
31 Efficacy and Safety of Mesotherapy With Minoxidil 0.5%/2ml for Androgenetic Alopecia in Female Patients Unknown status NCT01655108 Phase 3 Minoxidil;Saline
32 Reflexology's Effect on Polycystic Ovary Syndrome: A Pilot Study Unknown status NCT00746148 Phase 3
33 Reflexology's Effect on Polycystic Ovary Syndrome (PCOS) Unknown status NCT00744510 Phase 3
34 Treatment of the Recessive Nonbullous Congenital Ichthyosis by the Epigallocatechine Cutaneous Unknown status NCT01222000 Phase 3 apply VEREGEN ® 10 % on a randomized area and the moisturizing cream of the other side;apply VEREGEN ® 10 % on a randomized area and the moisturizing cream of the other side
35 Safety and Efficacy Study of Ara-c at 18 gm/m2 Versus 12 gm/m2 for 3 Cycles Each in AML Consolidation Unknown status NCT01615757 Phase 3 Ara-c;Ara-c
36 Valproate and Levocarnitine in Children With Spinal Muscular Atrophy Unknown status NCT01671384 Phase 3 Valproate, Levocarnitine;Placebo
37 The Randomized Double-blind Placebo-controlled Trial of Intralesional Botulinum Toxin A Injection for Recalcitrant Alopecia Totalis and Alopecia Universalis Completed NCT00997815 Phase 2, Phase 3 Botulinum toxin A;Normal saline injection
38 Phase II Randomized Bilateral Comparison of Topical Targretin Gel 1% in Alopecia Areata Completed NCT00063076 Phase 2, Phase 3 Targretin Gel 1%
39 A Long-term Study to Determine Safety and Efficacy of Dutasteride in Male Subjects With Androgenetic Alopecia Completed NCT01831791 Phase 3 Dutasteride 0.5 mg
40 Sexual Function in Men Receiving Dutasteride for Androgenetic Alopecia Completed NCT02014584 Phase 3 Dutasteride;Placebo
41 Efficacy and Safety Study to Compare Two Minoxidil Formulations on Women With Androgenetic Alopecia Completed NCT00958750 Phase 3 minoxidil
42 A Trial of Clobetasol Propionate Versus Hydrocortisone in Children With Alopecia Areata Completed NCT01453686 Phase 3 Hydrocortisone 1%;Clobetasol Propionate 0.05%
43 A Study To Assess The Efficacy And Safety Of Dutasteride 0.5mg Once Daily For 6 Months In The Treatment Of Male Subjects With Androgenetic Alopecia Completed NCT00441116 Phase 3 Dutasteride 0.5mg oral tablets
44 Dutasteride Versus Placebo and Finasteride in Men With Androgenetic Alopecia Completed NCT01231607 Phase 3 1mg Finasteride active;0.02mg dutasteride;0.1mg dutasteride;0.5mg dutasteride;Finasteride placebo;Dutasteride placebo
45 A Study to Evaluate the Effectiveness and Safety of 5 Percent Minoxidil Foam in the Treatment of Male Pattern Hair Loss Completed NCT00151515 Phase 3 minoxidil
46 Clinical Trial in Females With Female Pattern Hair Loss Completed NCT01145625 Phase 3 5% Minoxidil;2% Minoxidil
47 Clinical Trial in Females for Female Pattern Hair Loss Completed NCT01226459 Phase 3 5% Minoxidil Topical Foam;Vehicle Topical Foam
48 Study to Evaluate the Efficacy and Safety of P-3074 Topical Solution in the Treatment of Androgenetic Alopecia Completed NCT03004469 Phase 3 P-3074;Finasteride;Vehicle
49 Enhancing Hair Density With Platelet Rich Fibrin Matrix (PRFM) Completed NCT01590238 Phase 3
50 Efficacy Study of Minoxidil Lotion Versus Combined Minoxidil and Finasteride Lotion to Treat Male Pattern Hair Loss Completed NCT01391156 Phase 3 3%Minoxidil lotion;3% Minoxidil with 0.1% Finasteride lotion

Search NIH Clinical Center for Alopecia

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: alopecia

Genetic Tests for Alopecia

Genetic tests related to Alopecia:

# Genetic test Affiliating Genes
1 Alopecia 29

Anatomical Context for Alopecia

MalaCards organs/tissues related to Alopecia:

41
Lung, Breast, Brain, Skin, Ovary, Testes, Prostate
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Alopecia:
# Tissue Anatomical CompartmentCell Relevance
1 Hair Hair Follicle Fetal Hair Placode Cells Affected by disease
2 Hair Hair Follicle Fetal Matrix Cells Affected by disease
3 Hair Dermal Papilla Guard Dermal Papilla Cells Affected by disease
4 Hair Hair Follicle Primary Hair Placode Cells Affected by disease

Publications for Alopecia

Articles related to Alopecia:

(show top 50) (show all 2264)
# Title Authors Year
1
Alopecia areata after dupilumab for atopic dermatitis. ( 29387767 )
2018
2
Alopecia areata. ( 29908825 )
2018
3
Frontal Fibrosing Alopecia and Concomitant Lichen Planus Pigmentosus: A Case Series of Seven African American Women. ( 29601616 )
2018
4
Possible association between androgenic alopecia and risk of prostate cancer and testicular germ cell tumor: a systematic review and meta-analysis. ( 29529997 )
2018
5
Chronological clinicopathological characterization of rapidly progressive alopecia areata resistant to multiple i.v. corticosteroid pulse therapies: An implication for improving the efficacy. ( 29963718 )
2018
6
Unusual progression of renal cell carcinoma with carcinomatosis peritoneii and Krukenberg tumour and alopecia with sunitinib therapy in young female. ( 29409504 )
2018
7
Alopecia Areata-like Hair Loss Accompanying Toxic Epidermal Necrolysis. ( 29856464 )
2018
8
Coexistence of Dermatomyositis and Alopecia Areata: Insight into Pathogenesis. ( 29854645 )
2018
9
An investigation of vitamin D status in alopecia areata. ( 29869122 )
2018
10
An Open-Label Pilot Study to Evaluate the Efficacy of Tofacitinib in Moderate to Severe Patch Type Alopecia Areata, Totalis and Universalis. ( 29452121 )
2018
11
Fibroblast cell-based therapy prevents induction of alopecia areata in an experimental model. ( 29871523 )
2018
12
Histopathology of facial papules in frontal fibrosing alopecia and therapeutic response to oral isotretinoin. ( 29332726 )
2018
13
Ultraviolet filters in hair-care products: a possible link with frontal fibrosing alopecia and lichen planopilaris. ( 28994172 )
2018
14
Frontal fibrosing alopecia and cutaneous comorbidities: A potential relationship with rosacea. ( 29447678 )
2018
15
5-alpha-reductase inhibitor treatment for frontal fibrosing alopecia: an evidence-based treatment update. ( 29524253 )
2018
16
Prognosis, treatment, and disease outcomes in frontal fibrosing alopecia: A retrospective review of 92 cases. ( 29241787 )
2018
17
IgG4-related disease presenting with scarring alopecia of the scalp. ( 29892674 )
2018
18
Detection of titanium nanoparticles in the hair shafts of a patient with frontal fibrosing alopecia. ( 29578625 )
2018
19
Vitamin D-Dependent Rickets Type II with Alopecia: A Rare Case Report. ( 29692463 )
2018
20
Acknowledging the pseudo "fringe sign" in frontal fibrosing alopecia has diagnostic and prognostic implications. ( 29241801 )
2018
21
Annular Alopecia Areata: A Morphologically Rare Variant. ( 29440858 )
2018
22
Buschke-Ollendorff syndrome due to a novel LEMD3 mutation - an unusual case of alopecia. ( 29465813 )
2018
23
Quality of life in mild and severe alopecia areata patients. ( 29872683 )
2018
24
Prescribing Habits for Androgenic Alopecia Among Dermatologists in Spain in 2017: A Cross-Sectional Study. ( 29656764 )
2018
25
The risk of alopecia areata and other related autoimmune diseases in patients with sleep disorders: a Korean population-based retrospective cohort study. ( 29955877 )
2018
26
Alopecia Areata: The Clinical Situation. ( 29273111 )
2018
27
Case Report of Connubial Frontal Fibrosing Alopecia. ( 29769781 )
2018
28
Spontaneous hair regrowth in eight patients with severe alopecia areata. ( 29931820 )
2018
29
Clinical Description of Frontal Fibrosing Alopecia with Concomitant Lichen Planopilaris. ( 29765970 )
2018
30
Sarcoidosis Presenting as Frontal Fibrosing Alopecia: A Master Mimicker or a Coincidental Finding? ( 29293480 )
2018
31
Platelet-Rich Plasma for the Treatment of Androgenic Alopecia: A Systematic Review. ( 29954021 )
2018
32
Big Data Reveal Insights into Alopecia Areata Comorbidities. ( 29273109 )
2018
33
Immunoregulatory Effects of Myeloid-Derived Suppressor Cell Exosomes in Mouse Model of Autoimmune Alopecia Areata. ( 29951053 )
2018
34
Frontal fibrosing alopecia after antiandrogen hormonal therapy in a male patient. ( 29377270 )
2018
35
Persistent neutrophilic scarring alopecia triggered by anti-TNF blockade for Crohn's disease. ( 29976546 )
2018
36
Association of Uterine Leiomyomas With Central Centrifugal Cicatricial Alopecia. ( 29282458 )
2018
37
'Corkscrews' on the patchy alopecia of a girl. ( 29950301 )
2018
38
Retrospective review of 18 British South Asian women with frontal fibrosing alopecia. ( 29384198 )
2018
39
Melatonin vitamin C-based nanovesicles for treatment of androgenic alopecia: Design, characterization and clinical appraisal. ( 29981403 )
2018
40
Fibroproliferative Genes are Preferentially Expressed in Central Centrifugal Cicatricial Alopecia. ( 29913259 )
2018
41
Hemorrhagic Ischemic Retinal Vasculitis and Alopecia Areata as a Manifestation of HLA-B27. ( 29304269 )
2018
42
Mechanical and Controlled PRP Injections in Patients Affected by Androgenetic Alopecia. ( 29443105 )
2018
43
Comparison of the Efficacy of Homologous and Autologous Platelet-Rich Plasma (PRP) for Treating Androgenic Alopecia. ( 29101437 )
2018
44
A novel PLEC nonsense homozygous mutation (c.7159Ga88>a88T; p.Glu2387*) causes epidermolysis bullosa simplex with muscular dystrophy and diffuse alopecia: a case report. ( 29352809 )
2018
45
Facial Papules in Frontal Fibrosing Alopecia: Good Response to Isotretinoin. ( 29395031 )
2018
46
Updated diagnostic criteria for frontal fibrosing alopecia. ( 29241802 )
2018
47
Applying the Common Sense Model to predicting quality of life in alopecia areata: The role of illness perceptions and coping strategies. ( 29355049 )
2018
48
Photopatch and patch testing in 63 frontal fibrosing alopecia patients: a case series. ( 29962055 )
2018
49
Development and pilot-testing of the Alopecia Areata Assessment Tool (ALTO). ( 29874239 )
2018
50
A hypothetical pathogenesis model for androgenic alopecia: clarifying the dihydrotestosterone paradox and rate-limiting recovery factors. ( 29407002 )
2018

Variations for Alopecia

ClinVar genetic disease variations for Alopecia:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 SASH1 NM_015278.4(SASH1): c.1849G> A (p.Glu617Lys) single nucleotide variant Likely pathogenic rs587781245 GRCh38 Chromosome 6, 148533885: 148533885
2 SASH1 NM_015278.4(SASH1): c.1849G> A (p.Glu617Lys) single nucleotide variant Likely pathogenic rs587781245 GRCh37 Chromosome 6, 148855021: 148855021
3 EMILIN2; LPIN2; METTL4; MYL12A; MYL12B; MYOM1; NDC80; SMCHD1; TGIF1 GRCh37/hg19 18p11.32-11.31(chr18: 1345040-3479168) copy number loss Uncertain significance GRCh37 Chromosome 18, 1345040: 3479168

Expression for Alopecia

Search GEO for disease gene expression data for Alopecia.

Pathways for Alopecia

Pathways related to Alopecia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.22 CLDN1 DSP GJA1
2 10.3 CLDN1 DSP GJA1

GO Terms for Alopecia

Cellular components related to Alopecia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 fascia adherens GO:0005916 8.96 DSP GJA1
2 intermediate filament GO:0005882 8.92 DSP GJA1 KRT14 KRT86

Biological processes related to Alopecia according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.93 AIRE AR AUTS2 FOXN1 TP63 VDR
2 animal organ morphogenesis GO:0009887 9.61 FOXN1 TP63 VDR
3 cornification GO:0070268 9.5 DSP KRT14 KRT86
4 cell-cell junction organization GO:0045216 9.49 CLDN1 GJA1
5 decidualization GO:0046697 9.48 GJA1 VDR
6 regulation of bone mineralization GO:0030500 9.4 AHSG GJA1
7 establishment of skin barrier GO:0061436 9.37 CLDN1 TP63
8 keratinocyte differentiation GO:0030216 9.33 DSP FOXN1 TP63
9 prostate gland development GO:0030850 9.26 AR TP63
10 epidermis development GO:0008544 9.26 DSP FOXN1 KRT14 TP63
11 thymus epithelium morphogenesis GO:0097536 8.62 AIRE FOXN1

Sources for Alopecia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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