AGA
MCID: ALP061
MIFTS: 47

Alopecia, Androgenetic, 1 (AGA)

Categories: Rare diseases

Aliases & Classifications for Alopecia, Androgenetic, 1

MalaCards integrated aliases for Alopecia, Androgenetic, 1:

Name: Alopecia, Androgenetic, 1 57 29 13 38 73
Androgenetic Alopecia 57 38 53 25 73
Androgenic Alopecia 53 25
Androgenetic Alopecia; Aga 57
Female Pattern Baldness 25
Female Pattern Alopecia 73
Male Pattern Alopecia 25
Male Pattern Baldness 25
Alopecia Androgenetic 55
Pattern Baldness 25
Aga1 57
Aga 57

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant in males
recessive in females


HPO:

32
alopecia, androgenetic, 1:
Inheritance sex-limited autosomal dominant


Classifications:



External Ids:

OMIM 57 109200
SNOMED-CT via HPO 69 278040002 56317004

Summaries for Alopecia, Androgenetic, 1

OMIM : 57 Androgenetic alopecia is characterized by a loss of hair from the scalp that follows a defined pattern (Hamilton, 1951). It occurs in women as well as in men. It is caused by a shortening of the anagen (growth) phase and miniaturization of the hair follicle, which results in the formation of progressively thinner, shorter hair (Bergfeld, 1995). In men, the condition is often referred to as male pattern baldness (MPB) and appears to be androgen-dependent (Hamilton, 1942). The condition is hereditary, and follows a pattern that may be consistent with an autosomal dominant trait (Osborn, 1916). Linkage evidence for an autosomal locus on 3q26 (AGA1) has been identified (Hillmer et al., 2008). See 300710 (AGA2) for a discussion of X linkage of androgenetic alopecia. A third locus has been found on chromosome 20p11 (AGA3; 612421). (109200)

MalaCards based summary : Alopecia, Androgenetic, 1, also known as androgenetic alopecia, is related to androgenic alopecia and prostatic hyperplasia, benign. An important gene associated with Alopecia, Androgenetic, 1 is AGA3 (Alopecia, Androgenetic, 3), and among its related pathways/superpathways are Transcription Androgen Receptor nuclear signaling and Metabolism of steroid hormones. Affiliated tissues include prostate, skin and heart, and related phenotypes are alopecia and endocrine/exocrine gland

NIH Rare Diseases : 53 Androgenetic alopecia is a common form of hair loss in both men and women. In men, hair is usually lost in a well-defined pattern, beginning above both temples and is usually referred to as male-pattern baldness. Over time, the hairline recedes to form a characteristic 'M' shape. Hair also thins near the top of the head, often progressing to partial or complete baldness. The pattern of hair loss in women differs from men (female pattern hair loss). In women, the hair becomes thinner all over the head, and the hairline does not recede. Androgenetic alopecia in women rarely leads to total baldness. A variety of genetic and environmental factors likely play a role in causing this condition. Mutations in the AR gene have also been associated with androgenetic alopecia.

Genetics Home Reference : 25 Androgenetic alopecia is a common form of hair loss in both men and women. In men, this condition is also known as male-pattern baldness. Hair is lost in a well-defined pattern, beginning above both temples. Over time, the hairline recedes to form a characteristic "M" shape. Hair also thins at the crown (near the top of the head), often progressing to partial or complete baldness.

Related Diseases for Alopecia, Androgenetic, 1

Diseases in the Alopecia, Androgenetic, 1 family:

Alopecia, Androgenetic, 2 Alopecia, Androgenetic, 3

Diseases related to Alopecia, Androgenetic, 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 androgenic alopecia 32.9 AR CYP19A1 SHBG
2 prostatic hyperplasia, benign 30.4 AR CYP19A1 SRD5A2
3 hermaphroditism 30.3 SHBG SRD5A2
4 hyperandrogenism 29.7 CYP19A1 CYP21A2 SHBG
5 osteoporosis 28.6 AR CYP19A1 SHBG TGFB2
6 prostate cancer 26.4 AR CFLAR CYP19A1 SHBG SRD5A1 SRD5A2
7 aspartylglucosaminuria 12.3
8 alopecia, androgenetic, 2 12.2
9 alopecia, androgenetic, 3 12.2
10 lysosomal storage disease 11.3
11 marie unna congenital hypotrichosis 11.2
12 alopecia 11.2
13 fabry disease 11.1
14 angiokeratoma 11.1
15 hypotrichosis 1 11.1
16 hypotrichosis simplex 11.1
17 fucosidosis 11.0
18 galactosemia 11.0
19 47, xxy 10.5 AR SHBG
20 alopecia areata 10.5
21 postmenopausal atrophic vaginitis 10.5 AR SHBG
22 prostatitis 10.4
23 hypoactive sexual desire disorder 10.4 CYP19A1 SHBG
24 telogen effluvium 10.4
25 gender identity disorder 10.3 AR CYP19A1
26 diabetes mellitus, noninsulin-dependent 10.3
27 aging 10.3
28 5-alpha reductase deficiency 10.2 SRD5A1 SRD5A2
29 estrogen excess 10.2 CYP19A1 SHBG
30 lichen planopilaris 10.2
31 androgen insensitivity syndrome 10.1 AR SHBG SRD5A2
32 arteries, anomalies of 10.1
33 coronary artery anomaly 10.1
34 heart disease 10.1
35 frontal fibrosing alopecia 10.1
36 complete androgen insensitivity syndrome 10.1 AR CYP19A1 SHBG
37 prostatic hypertrophy 10.1 AR CYP19A1
38 luteoma 10.1 CYP19A1 CYP21A2
39 gynecomastia 10.1 AR CYP19A1 SHBG
40 reproductive system disease 10.0 AR CYP19A1 SHBG
41 pseudohermaphroditism 10.0 AR CYP19A1 SRD5A2
42 coronary heart disease 1 10.0
43 dermatitis 10.0
44 psoriasis 10.0
45 type i 10.0
46 prostatic adenoma 10.0 AR SHBG SRD5A1
47 penis agenesis 10.0 AR SRD5A1 SRD5A2
48 transsexualism 9.9 AR CYP19A1 CYP21A2
49 antley-bixler syndrome 9.9 CYP19A1 CYP21A2
50 breast cancer 9.9

Graphical network of the top 20 diseases related to Alopecia, Androgenetic, 1:



Diseases related to Alopecia, Androgenetic, 1

Symptoms & Phenotypes for Alopecia, Androgenetic, 1

Symptoms via clinical synopsis from OMIM:

57
Hair:
early baldness


Clinical features from OMIM:

109200

Human phenotypes related to Alopecia, Androgenetic, 1:

32
# Description HPO Frequency HPO Source Accession
1 alopecia 32 HP:0001596

MGI Mouse Phenotypes related to Alopecia, Androgenetic, 1:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.17 AR CFLAR CYP19A1 SRD5A1 SRD5A2 TGFB2

Drugs & Therapeutics for Alopecia, Androgenetic, 1

Search Clinical Trials , NIH Clinical Center for Alopecia, Androgenetic, 1

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Alopecia, Androgenetic, 1 cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Alopecia, Androgenetic, 1:
RepliCel Hair-01 (RCH-01), hair follicle-derived mesenchymal stem cells for treatment of androgenetic alopecia
Embryonic/Adult Cultured Cells Related to Alopecia, Androgenetic, 1:
Hair follicle mesenchymal stem cells (RepliCel Hair-01)

Genetic Tests for Alopecia, Androgenetic, 1

Genetic tests related to Alopecia, Androgenetic, 1:

# Genetic test Affiliating Genes
1 Alopecia, Androgenetic, 1 29

Anatomical Context for Alopecia, Androgenetic, 1

MalaCards organs/tissues related to Alopecia, Androgenetic, 1:

41
Prostate, Skin, Heart, Testes, Endothelial, Thyroid, Breast

Publications for Alopecia, Androgenetic, 1

Articles related to Alopecia, Androgenetic, 1:

(show top 50) (show all 432)
# Title Authors Year
1
Mechanical and Controlled PRP Injections in Patients Affected by Androgenetic Alopecia. ( 29443105 )
2018
2
A proprietary herbal extract against hair loss in androgenetic alopecia and telogen effluvium: a placebo-controlled, single-blind, clinical-instrumental study. ( 29945259 )
2018
3
Quality of Life with Alopecia Areata versus Androgenetic Alopecia Assessed Using Hair Specific Skindex-29. ( 29853767 )
2018
4
A Meta-analysis On Evidence Of Platelet-rich Plasma for Androgenetic Alopecia. ( 29440850 )
2018
5
A randomized, double-blind controlled study of the efficacy and safety of topical solution of 0.25% finasteride admixed with 3% minoxidil versus 3% minoxidil solution in the treatment of male androgenetic alopecia. ( 29972712 )
2018
6
Efficacy and Safety of a Low-Level Light Therapy for Androgenetic Alopecia: A 24-Week, Randomized, Double-Blind, Self-Comparison, Sham Device-Controlled Trial. ( 29957664 )
2018
7
Social selection favours offspring prone to the development of androgenetic alopecia. ( 29254307 )
2017
8
Mesotherapy with Dutasteride in the Treatment of Androgenetic Alopecia. ( 28932074 )
2017
9
Is there a pathogenetic link between frontal fibrosing alopecia, androgenetic alopecia and fibrosing alopecia in a pattern distribution? ( 29224248 )
2017
10
A Pilot Study to Evaluate Effectiveness of Botulinum Toxin in Treatment of Androgenetic Alopecia in Males. ( 29403190 )
2017
11
Higher plasma leptin is associated with higher risk of androgenetic alopecia in men. ( 28423238 )
2017
12
Stem cell therapy as a novel therapeutic intervention for resistant cases of alopecia areata and androgenetic alopecia. ( 27553744 )
2016
13
Commentary on A New Subtype of Lichen Planopilaris Affecting Vellus Hairs and Clinically Mimicking Androgenetic Alopecia. ( 27661431 )
2016
14
Psychosocial Impairment as a Possible Cause of Sexual Dysfunction among Young Men with Mild Androgenetic Alopecia: A Cross-sectional Crowdsourcing Web-based Study. ( 27149130 )
2016
15
Meta-analysis of efficacy of platelet-rich plasma therapy for androgenetic alopecia. ( 27152474 )
2016
16
The role of oxidative stress in early-onset androgenetic alopecia. ( 27987270 )
2016
17
Are 2D:4D finger-length ratios an indicator of androgenetic alopecia in males? ( 27192513 )
2016
18
A Mechanistic Model of Platelet-Rich Plasma Treatment for Androgenetic Alopecia. ( 27631460 )
2016
19
Relation of urinary stone disease with androgenetic alopecia and serum testosterone levels. ( 27155830 )
2016
20
[Association of eight single nucleotide polymorphisms of chromosomes 20 and X with androgenetic alopecia among ethnic Han Chinese from Yunnan]. ( 27264827 )
2016
21
Assessment of vitamin D receptors in alopecia areata and androgenetic alopecia. ( 27151518 )
2016
22
Differential Expression between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia. ( 27060448 )
2016
23
Long-term efficacy and safety of the dual 5-alpha reductase blocker dutasteride on male androgenetic alopecia patients. ( 27988928 )
2016
24
A New Subtype of Lichen Planopilaris Affecting Vellus Hairs and Clinically Mimicking Androgenetic Alopecia. ( 27661430 )
2016
25
A Single-Centre, Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Investigate the Efficacy and Safety of Minoxidil Topical Foam in Frontotemporal and Vertex Androgenetic Alopecia in Men. ( 25765348 )
2015
26
Lichen Planopilaris in the Androgenetic Alopecia Area: A Pitfall for Hair Transplantation. ( 27171849 )
2015
27
Erosive pustular dermatosis of the scalp following topical latanoprost for androgenetic alopecia. ( 25627907 )
2015
28
Characteristics of nonbalding scalp zones of androgenetic alopecia in East Asians. ( 25532463 )
2015
29
Conditions simulating androgenetic alopecia. ( 25571781 )
2015
30
Rosemary oil vs minoxidil 2% for the treatment of androgenetic alopecia: a randomized comparative trial. ( 25842469 )
2015
31
Trichoscopic findings of androgenetic alopecia and their association with disease severity. ( 25810236 )
2015
32
Oxidative stress-associated senescence in dermal papilla cells of men with androgenetic alopecia. ( 25647436 )
2015
33
Safety concerns regarding 5I+ reductase inhibitors for the treatment of androgenetic alopecia. ( 25871957 )
2015
34
The association of androgenetic alopecia and insulin resistance is independent of hyperandrogenemia: A case-control study. ( 25781062 )
2015
35
Lack of concordance and linkage disequilibrium among brothers for androgenetic alopecia and CAG/GGC haplotypes of the androgen receptor gene in Mexican families. ( 26178169 )
2015
36
Androgenetic alopecia and polymorphism of the androgen receptor gene (SNP rs6152) in patients with benign prostate hyperplasia or prostate cancer. ( 24665929 )
2015
37
Five-year efficacy of finasteride in 801 Japanese men with androgenetic alopecia. ( 25903108 )
2015
38
The efficacy and safety of 5I+-reductase inhibitors in androgenetic alopecia: a network meta-analysis and benefit-risk assessment of finasteride and dutasteride. ( 23768246 )
2014
39
Hair diameter vs. hair density in male androgenetic alopecia. ( 25409994 )
2014
40
Contribution of hair density and hair diameter to the appearance and progression of androgenetic alopecia in Japanese men. ( 24981717 )
2014
41
Commentary on 'Platelet-rich plasma for androgenetic alopecia: a pilot study'. ( 25158780 )
2014
42
Impact of phototrichogram education on satisfaction of patients with androgenetic alopecia in clinical practice. ( 24986264 )
2014
43
Inflammatory markers and Lp(a) levels as cardiovascular risk factors in androgenetic alopecia. ( 25536913 )
2014
44
Immunohistochemical evaluation of androgen receptor and nerve structure density in human prepuce from patients with persistent sexual side effects after finasteride use for androgenetic alopecia. ( 24959691 )
2014
45
Association of premature androgenetic alopecia and metabolic syndrome in a young Indian population. ( 25191037 )
2014
46
Study of platelet-rich plasma injections in the treatment of androgenetic alopecia through an one-year period. ( 25722600 )
2014
47
Acute telogen effluvium onset event is associated with the presence of female androgenetic alopecia: potential therapeutic implications. ( 24850277 )
2014
48
Androgenetic alopecia, metabolic syndrome, and insulin resistance: Is there any association? A case-control study. ( 25165643 )
2014
49
A Review of Medical and Surgical Treatment Options for Androgenetic Alopecia. ( 25188680 )
2014
50
Assessment of the usefulness of dihydrotestosterone in the diagnostics of patients with androgenetic alopecia. ( 25254005 )
2014

Variations for Alopecia, Androgenetic, 1

Expression for Alopecia, Androgenetic, 1

Search GEO for disease gene expression data for Alopecia, Androgenetic, 1.

Pathways for Alopecia, Androgenetic, 1

GO Terms for Alopecia, Androgenetic, 1

Cellular components related to Alopecia, Androgenetic, 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum membrane GO:0005789 9.55 CYP19A1 CYP21A2 SRD5A1 SRD5A2 STS
2 organelle membrane GO:0031090 9.13 CYP21A2 SRD5A1 SRD5A2
3 cell body fiber GO:0070852 8.62 SRD5A1 SRD5A2

Biological processes related to Alopecia, Androgenetic, 1 according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 steroid metabolic process GO:0008202 9.62 CYP21A2 SRD5A1 SRD5A2 STS
2 negative regulation of extrinsic apoptotic signaling pathway GO:2001237 9.61 AR CFLAR
3 cellular response to estradiol stimulus GO:0071392 9.61 CFLAR SRD5A1
4 cellular response to dexamethasone stimulus GO:0071549 9.6 CFLAR SRD5A1
5 sterol metabolic process GO:0016125 9.59 CYP19A1 CYP21A2
6 cell growth GO:0016049 9.58 AR TGFB2
7 male genitalia development GO:0030539 9.58 SRD5A1 SRD5A2
8 response to testosterone GO:0033574 9.58 CFLAR SRD5A1 SRD5A2
9 uterus development GO:0060065 9.57 CYP19A1 TGFB2
10 hypothalamus development GO:0021854 9.56 SRD5A1 SRD5A2
11 male gonad development GO:0008584 9.56 AR SRD5A1 SRD5A2 TGFB2
12 androgen biosynthetic process GO:0006702 9.55 SRD5A1 SRD5A2
13 progesterone metabolic process GO:0042448 9.54 SRD5A1 SRD5A2
14 sex differentiation GO:0007548 9.54 AR SRD5A1 SRD5A2
15 cellular response to testosterone stimulus GO:0071394 9.52 AR SRD5A1
16 prostate gland growth GO:0060736 9.51 AR CYP19A1
17 testosterone biosynthetic process GO:0061370 9.49 CYP19A1 SRD5A2
18 response to follicle-stimulating hormone GO:0032354 9.48 SRD5A1 SRD5A2
19 steroid catabolic process GO:0006706 9.46 SRD5A2 STS
20 positive regulation of integrin biosynthetic process GO:0045726 9.43 AR TGFB2
21 androgen metabolic process GO:0008209 9.33 CYP19A1 SRD5A1 SRD5A2
22 steroid biosynthetic process GO:0006694 9.26 CYP19A1 CYP21A2 SRD5A1 SRD5A2
23 female genitalia development GO:0030540 8.8 CYP19A1 SRD5A1 SRD5A2

Molecular functions related to Alopecia, Androgenetic, 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.73 CYP19A1 CYP21A2 SRD5A1 SRD5A2
2 steroid hydroxylase activity GO:0008395 9.4 CYP19A1 CYP21A2
3 oxidoreductase activity, acting on the CH-CH group of donors GO:0016627 9.37 SRD5A1 SRD5A2
4 androgen binding GO:0005497 9.32 AR SHBG
5 3-oxo-5-alpha-steroid 4-dehydrogenase activity GO:0003865 9.26 SRD5A1 SRD5A2
6 cholestenone 5-alpha-reductase activity GO:0047751 9.16 SRD5A1 SRD5A2
7 amide binding GO:0033218 8.96 SRD5A1 SRD5A2
8 steroid binding GO:0005496 8.8 AR CYP21A2 SHBG

Sources for Alopecia, Androgenetic, 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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