AGA
MCID: ALP061
MIFTS: 55

Alopecia, Androgenetic, 1 (AGA)

Categories: Rare diseases

Aliases & Classifications for Alopecia, Androgenetic, 1

MalaCards integrated aliases for Alopecia, Androgenetic, 1:

Name: Alopecia, Androgenetic, 1 57 29 13 38 73
Androgenetic Alopecia 57 38 53 25 73
Androgenic Alopecia 53 25
Androgenetic Alopecia; Aga 57
Female Pattern Baldness 25
Female Pattern Alopecia 73
Male Pattern Alopecia 25
Male Pattern Baldness 25
Alopecia Androgenetic 55
Pattern Baldness 25
Aga1 57
Aga 57

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant in males
recessive in females


HPO:

32
alopecia, androgenetic, 1:
Inheritance sex-limited autosomal dominant


Classifications:



External Ids:

OMIM 57 109200
SNOMED-CT via HPO 69 278040002 56317004

Summaries for Alopecia, Androgenetic, 1

OMIM : 57 Androgenetic alopecia is characterized by a loss of hair from the scalp that follows a defined pattern (Hamilton, 1951). It occurs in women as well as in men. It is caused by a shortening of the anagen (growth) phase and miniaturization of the hair follicle, which results in the formation of progressively thinner, shorter hair (Bergfeld, 1995). In men, the condition is often referred to as male pattern baldness (MPB) and appears to be androgen-dependent (Hamilton, 1942). The condition is hereditary, and follows a pattern that may be consistent with an autosomal dominant trait (Osborn, 1916). Linkage evidence for an autosomal locus on 3q26 (AGA1) has been identified (Hillmer et al., 2008). See 300710 (AGA2) for a discussion of X linkage of androgenetic alopecia. A third locus has been found on chromosome 20p11 (AGA3; 612421). (109200)

MalaCards based summary : Alopecia, Androgenetic, 1, also known as androgenetic alopecia, is related to androgenic alopecia and prostatic hyperplasia, benign. An important gene associated with Alopecia, Androgenetic, 1 is AGA2 (Alopecia, Androgenetic, 2), and among its related pathways/superpathways are Transcription Androgen Receptor nuclear signaling and Metabolism of steroid hormones. Affiliated tissues include prostate, testes and skin, and related phenotypes are alopecia and endocrine/exocrine gland

Genetics Home Reference : 25 Androgenetic alopecia is a common form of hair loss in both men and women. In men, this condition is also known as male-pattern baldness. Hair is lost in a well-defined pattern, beginning above both temples. Over time, the hairline recedes to form a characteristic "M" shape. Hair also thins at the crown (near the top of the head), often progressing to partial or complete baldness.

NIH Rare Diseases : 53 Androgenetic alopecia is a common form of hair loss in both men and women. In men, hair is usually lost in a well-defined pattern, beginning above both temples and is usually referred to as male-pattern baldness. Over time, the hairline recedes to form a characteristic 'M' shape. Hair also thins near the top of the head, often progressing to partial or complete baldness. The pattern of hair loss in women differs from men (female pattern hair loss). In women, the hair becomes thinner all over the head, and the hairline does not recede. Androgenetic alopecia in women rarely leads to total baldness. A variety of genetic and environmental factors likely play a role in causing this condition. Mutations in the AR gene have also been associated with androgenetic alopecia.

Related Diseases for Alopecia, Androgenetic, 1

Diseases in the Alopecia, Androgenetic, 1 family:

Alopecia, Androgenetic, 2 Alopecia, Androgenetic, 3

Diseases related to Alopecia, Androgenetic, 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
# Related Disease Score Top Affiliating Genes
1 androgenic alopecia 33.1 SHBG CYP19A1 AR
2 prostatic hyperplasia, benign 30.3 SRD5A2 SRD5A1 SHBG AR
3 hyperandrogenism 30.2 SHBG CYP21A2 CYP19A1
4 polycystic ovary syndrome 29.9 SHBG CYP21A2 CYP19A1
5 prostate disease 29.8 SRD5A1 CYP19A1 AR
6 osteoporosis 29.7 TGFB2 SHBG CYP19A1 AR
7 prostate cancer 29.4 XIAP SRD5A2 SRD5A1 SHBG CYP19A1 CFLAR
8 aspartylglucosaminuria 12.5
9 alopecia, androgenetic, 2 12.3
10 alopecia, androgenetic, 3 12.3
11 lysosomal storage disease 11.4
12 alopecia 11.4
13 marie unna congenital hypotrichosis 11.4
14 fabry disease 11.3
15 angiokeratoma 11.3
16 hypotrichosis 1 11.2
17 hypotrichosis simplex 11.2
18 fucosidosis 11.2
19 galactosemia 11.2
20 glucocorticoid resistance, generalized 11.2
21 alopecia areata 10.7
22 telogen effluvium 10.5
23 rapidly involuting congenital hemangioma 10.4
24 lichen planopilaris 10.3
25 neurofibromatosis, type ii 10.3
26 arteries, anomalies of 10.3
27 coronary artery anomaly 10.3
28 heart disease 10.3
29 frontal fibrosing alopecia 10.3
30 hermaphroditism 10.2 SRD5A2 AR
31 pityriasis rubra pilaris 10.2
32 coronary heart disease 1 10.2
33 retinal dystrophy, iris coloboma, and comedogenic acne syndrome 10.2
34 dermatitis 10.2
35 psoriasis 10.2
36 47, xxy 10.2 SHBG AR
37 postmenopausal atrophic vaginitis 10.1 SHBG AR
38 hypoactive sexual desire disorder 10.1 SHBG CYP19A1
39 gender identity disorder 10.1 CYP19A1 AR
40 sebaceous gland disease 10.1 SHBG AR
41 5-alpha reductase deficiency 10.1 SRD5A2 SRD5A1
42 estrogen excess 10.1 SHBG CYP19A1
43 androgen insensitivity syndrome 10.0 SRD5A2 SHBG AR
44 complete androgen insensitivity syndrome 10.0 SHBG CYP19A1 AR
45 gynecomastia 10.0 SHBG CYP19A1 AR
46 prostatic hypertrophy 10.0 CYP19A1 AR
47 luteoma 10.0 CYP21A2 CYP19A1
48 pseudohermaphroditism 10.0 SRD5A2 CYP19A1 AR
49 gonadal disease 10.0 SHBG CYP19A1 AR
50 breast cancer 10.0

Graphical network of the top 20 diseases related to Alopecia, Androgenetic, 1:



Diseases related to Alopecia, Androgenetic, 1

Symptoms & Phenotypes for Alopecia, Androgenetic, 1

Symptoms via clinical synopsis from OMIM:

57
Hair:
early baldness


Clinical features from OMIM:

109200

Human phenotypes related to Alopecia, Androgenetic, 1:

32
# Description HPO Frequency HPO Source Accession
1 alopecia 32 HP:0001596

MGI Mouse Phenotypes related to Alopecia, Androgenetic, 1:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.17 AR CFLAR CYP19A1 SRD5A1 SRD5A2 TGFB2

Drugs & Therapeutics for Alopecia, Androgenetic, 1

Search Clinical Trials , NIH Clinical Center for Alopecia, Androgenetic, 1

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Alopecia, Androgenetic, 1 cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Alopecia, Androgenetic, 1:
RepliCel Hair-01 (RCH-01), hair follicle-derived mesenchymal stem cells for treatment of androgenetic alopecia
Embryonic/Adult Cultured Cells Related to Alopecia, Androgenetic, 1:
Hair follicle mesenchymal stem cells (RepliCel Hair-01)

Genetic Tests for Alopecia, Androgenetic, 1

Genetic tests related to Alopecia, Androgenetic, 1:

# Genetic test Affiliating Genes
1 Alopecia, Androgenetic, 1 29

Anatomical Context for Alopecia, Androgenetic, 1

MalaCards organs/tissues related to Alopecia, Androgenetic, 1:

41
Prostate, Testes, Skin, Bone, Heart, Breast, Ovary

Publications for Alopecia, Androgenetic, 1

Articles related to Alopecia, Androgenetic, 1:

(show top 50) (show all 617)
# Title Authors Year
1
Mechanical and Controlled PRP Injections in Patients Affected by Androgenetic Alopecia. ( 29443105 )
2018
2
A proprietary herbal extract against hair loss in androgenetic alopecia and telogen effluvium: a placebo-controlled, single-blind, clinical-instrumental study. ( 29945259 )
2018
3
Quality of Life with Alopecia Areata versus Androgenetic Alopecia Assessed Using Hair Specific Skindex-29. ( 29853767 )
2018
4
A Meta-analysis On Evidence Of Platelet-rich Plasma for Androgenetic Alopecia. ( 29440850 )
2018
5
A randomized, double-blind controlled study of the efficacy and safety of topical solution of 0.25% finasteride admixed with 3% minoxidil versus 3% minoxidil solution in the treatment of male androgenetic alopecia. ( 29972712 )
2018
6
Efficacy and Safety of a Low-Level Light Therapy for Androgenetic Alopecia: A 24-Week, Randomized, Double-Blind, Self-Comparison, Sham Device-Controlled Trial. ( 29957664 )
2018
7
Use of Minoxidil Sulfate versus Minoxidil Base in Androgenetic Alopecia Treatment: Friend or Foe? ( 30410915 )
2018
8
Acne development in male androgenetic alopecia. ( 30499125 )
2018
9
Evaluation of long-term efficacy of finasteride in Korean men with androgenetic alopecia using the basic and specific classification system. ( 30536893 )
2018
10
Dermoscopic pre- and posttreatment evaluation in patients with androgenetic alopecia on platelet-rich plasma-A prospective study. ( 30556270 )
2018
11
Minoxidil in the treatment of androgenetic alopecia. ( 30155952 )
2018
12
Comparison of quality of life in patients with androgenetic alopecia and alopecia areata. ( 30156613 )
2018
13
The new paradigm for androgenetic alopecia and plant-based folk remedies: 5α-reductase inhibition, reversal of secondary microinflammation and improving insulin resistance. ( 30195058 )
2018
14
Efficacy and Safety of a Topical Botanical in Female Androgenetic Alopecia: A Randomized, Single-Blinded, Vehicle-Controlled Study. ( 30197894 )
2018
15
Adverse Sexual Effects of Treatment with Finasteride or Dutasteride for Male Androgenetic Alopecia: A Systematic Review and Meta-analysis. ( 30206635 )
2018
16
Finasteride and Erectile Dysfunction in Patients with Benign Prostatic Hyperplasia or Male Androgenetic Alopecia. ( 30209896 )
2018
17
Estimation of Zinc and Iron Levels in the Serum and Hair of Women with Androgenetic Alopecia: Case-control Study. ( 30210156 )
2018
18
Synergistic effect of platelet-rich plasma injections and scalp lifting in androgenetic alopecia. ( 30217282 )
2018
19
Low-dose daily aspirin reduces topical minoxidil efficacy in androgenetic alopecia patients. ( 30226287 )
2018
20
Shedding light on the FDA's 510(k) approvals process: low-level laser therapy devices used in the treatment of androgenetic alopecia. ( 30252550 )
2018
21
Controversies in the treatment of androgenetic alopecia: The history of finasteride. ( 30253001 )
2018
22
Impact on Quality of Life in Patients who came with Androgenetic Alopecia for Hair Transplantion Surgery in a Clinic. ( 30387465 )
2018
23
Efficacy of platelet-rich plasma in androgenetic alopecia patients. ( 30393988 )
2018
24
HrQoL in hair loss-affected patients with alopecia areata, androgenetic alopecia and telogen effluvium: the role of personality traits and psychosocial anxiety. ( 30394586 )
2018
25
Evaluation of the Expression of Genes Associated with Inflammation and Apoptosis in Androgenetic Alopecia by Targeted RNA-Seq. ( 30410894 )
2018
26
Platelet-rich plasma on female androgenetic alopecia: Tested on 10 patients. ( 29707872 )
2018
27
Letter to the Editor: androgenetic alopecia; drug safety and therapeutic strategies. ( 29707969 )
2018
28
Response to the letter to the editor; Androgenetic alopecia; drug safety and therapeutic strategies. ( 29707983 )
2018
29
The tendency towards the development of psychosexual disorders in androgenetic alopecia according to the different stages of hair loss: a cross-sectional study. ( 29723381 )
2018
30
Bayesian measurement-error-driven hidden Markov regression model for calibrating the effect of covariates on multistate outcomes: Application to androgenetic alopecia. ( 29785802 )
2018
31
Systematic review of platelet-rich plasma (PRP) preparation and composition for the treatment of androgenetic alopecia. ( 29790267 )
2018
32
Efficacy of non-surgical treatments for androgenetic alopecia: a systematic review and network meta-analysis. ( 29797431 )
2018
33
New Perspectives on the Treatment of Androgenetic Alopecia. ( 29801692 )
2018
34
Association of Androgenetic Alopecia with Metabolic Syndrome: A Case-control Study on 100 Patients in a Tertiary Care Hospital in South India. ( 29911030 )
2018
35
Insights into Male Androgenetic Alopecia: Differential Gene Expression Profiling of Plucked Hair Follicles and Integration with Genetic Data. ( 30009830 )
2018
36
The effectiveness of adding low-level light therapy to minoxidil 5% solution in the treatment of patients with androgenetic alopecia. ( 30027912 )
2018
37
White and yellow dots as new trichoscopic signs of severe female androgenetic alopecia in dark skin phototypes. ( 30043983 )
2018
38
Injectable Platelet-, Leukocyte-, and Fibrin-Rich Plasma (iL-PRF) in the Management of Androgenetic Alopecia. ( 30045107 )
2018
39
Androgenetic Alopecia Treatment in Asian Men. ( 30057663 )
2018
40
Psychological assessment in 355 Chinese college students with androgenetic alopecia. ( 30075498 )
2018
41
Utility of Horizontal Sections of Scalp Biopsies in Differentiating between Androgenetic Alopecia and Alopecia Areata. ( 30092597 )
2018
42
Efficacy of 1,550-nm Erbium-Glass Fractional Laser Treatment and Its Effect on the Expression of Insulin-Like Growth Factor 1 and Wnt/β-Catenin in Androgenetic Alopecia. ( 30096107 )
2018
43
Finasteride nano-transferosomal gel formula for management of androgenetic alopecia: ex vivo investigational approach. ( 30104862 )
2018
44
Evaluating the Efficacy of Different Platelet-Rich Plasma Regimens for Management of Androgenetic Alopecia: A Single-Center, Blinded, Randomized Clinical Trial. ( 30141776 )
2018
45
The use of minoxidil in the treatment of male and female androgenetic alopecia: a story of more than 30 years. ( 29319278 )
2018
46
Gender-specific risk factors for androgenetic alopecia in the Korean general population: Associations with medical comorbidities and general health behaviors. ( 29330930 )
2018
47
Automated digital image analysis (TrichoScan) in male patients with androgenetic alopecia; comparison with manual marking of hairs on trichoscopic images. ( 29363174 )
2018
48
Androgenetic alopecia; drug safety and therapeutic strategies. ( 29363345 )
2018
49
Finasteride Topical Delivery Systems for Androgenetic Alopecia. ( 29366416 )
2018
50
Effectiveness of Platelet-Rich Plasma for Androgenetic Alopecia: A Review of the Literature. ( 29457005 )
2018

Variations for Alopecia, Androgenetic, 1

Expression for Alopecia, Androgenetic, 1

Search GEO for disease gene expression data for Alopecia, Androgenetic, 1.

Pathways for Alopecia, Androgenetic, 1

GO Terms for Alopecia, Androgenetic, 1

Cellular components related to Alopecia, Androgenetic, 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum membrane GO:0005789 9.55 CYP19A1 CYP21A2 SRD5A1 SRD5A2 STS
2 organelle membrane GO:0031090 9.13 CYP21A2 SRD5A1 SRD5A2
3 cell body fiber GO:0070852 8.62 SRD5A1 SRD5A2

Biological processes related to Alopecia, Androgenetic, 1 according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.79 AR SRD5A2 TGFB2
2 steroid metabolic process GO:0008202 9.67 CYP21A2 SRD5A1 SRD5A2 STS
3 negative regulation of extrinsic apoptotic signaling pathway GO:2001237 9.61 AR CFLAR
4 cellular response to estradiol stimulus GO:0071392 9.6 CFLAR SRD5A1
5 cellular response to dexamethasone stimulus GO:0071549 9.59 CFLAR SRD5A1
6 sterol metabolic process GO:0016125 9.58 CYP19A1 CYP21A2
7 male genitalia development GO:0030539 9.58 SRD5A1 SRD5A2
8 response to testosterone GO:0033574 9.58 CFLAR SRD5A1 SRD5A2
9 uterus development GO:0060065 9.57 CYP19A1 TGFB2
10 hypothalamus development GO:0021854 9.56 SRD5A1 SRD5A2
11 male gonad development GO:0008584 9.56 AR SRD5A1 SRD5A2 TGFB2
12 androgen biosynthetic process GO:0006702 9.55 SRD5A1 SRD5A2
13 cellular response to testosterone stimulus GO:0071394 9.54 AR SRD5A1
14 prostate gland growth GO:0060736 9.52 AR CYP19A1
15 response to follicle-stimulating hormone GO:0032354 9.51 SRD5A1 SRD5A2
16 sex differentiation GO:0007548 9.5 AR SRD5A1 SRD5A2
17 testosterone biosynthetic process GO:0061370 9.49 CYP19A1 SRD5A2
18 androgen catabolic process GO:0006710 9.48 CYP19A1 SRD5A1
19 steroid catabolic process GO:0006706 9.46 SRD5A2 STS
20 positive regulation of integrin biosynthetic process GO:0045726 9.43 AR TGFB2
21 androgen metabolic process GO:0008209 9.33 CYP19A1 SRD5A1 SRD5A2
22 steroid biosynthetic process GO:0006694 9.26 CYP19A1 CYP21A2 SRD5A1 SRD5A2
23 female genitalia development GO:0030540 8.8 CYP19A1 SRD5A1 SRD5A2

Molecular functions related to Alopecia, Androgenetic, 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.73 CYP19A1 CYP21A2 SRD5A1 SRD5A2
2 steroid hydroxylase activity GO:0008395 9.4 CYP19A1 CYP21A2
3 oxidoreductase activity, acting on the CH-CH group of donors GO:0016627 9.37 SRD5A1 SRD5A2
4 androgen binding GO:0005497 9.32 AR SHBG
5 3-oxo-5-alpha-steroid 4-dehydrogenase activity GO:0003865 9.26 SRD5A1 SRD5A2
6 amide binding GO:0033218 9.16 SRD5A1 SRD5A2
7 cholestenone 5-alpha-reductase activity GO:0047751 8.96 SRD5A1 SRD5A2
8 steroid binding GO:0005496 8.8 AR CYP21A2 SHBG

Sources for Alopecia, Androgenetic, 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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