MCID: ALP048
MIFTS: 32

Alopecia Totalis

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Alopecia Totalis

MalaCards integrated aliases for Alopecia Totalis:

Name: Alopecia Totalis 53 59 73
Loss of All Scalp Hair 53

Characteristics:

Orphanet epidemiological data:

59
alopecia totalis
Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 59  
Rare skin diseases


External Ids:

Orphanet 59 ORPHA700
UMLS via Orphanet 74 C0263504
ICD10 via Orphanet 34 L63.0
ICD10 33 L63.0
SNOMED-CT via HPO 69 278040002 298000004 56317004
UMLS 73 C0263504

Summaries for Alopecia Totalis

NIH Rare Diseases : 53 Alopecia totalis (AT) is a condition characterized by the complete loss of hair on the scalp. It is an advanced form of alopecia areata a condition that causes round patches of hair loss. Although the exact cause of AT is unknown, it is thought to be an autoimmune condition in which the immune system mistakenly attacks the hair follicles. Roughly 20% of affected people have a family member with alopecia, suggesting that genetic factors may contribute to the development of AT. There is currently no cure for AT, but sometimes hair regrowth occurs on it's own, even after many years.

MalaCards based summary : Alopecia Totalis, also known as loss of all scalp hair, is related to alopecia areata and alopecia. An important gene associated with Alopecia Totalis is TMPO (Thymopoietin). The drugs Hydroxychloroquine and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include skin, thyroid and testes, and related phenotypes are alopecia and scalp hair loss

Wikipedia : 76 Alopecia totalis is the loss of all skull and facial hair. Its causes are unclear, but believed to be... more...

Related Diseases for Alopecia Totalis

Graphical network of the top 20 diseases related to Alopecia Totalis:



Diseases related to Alopecia Totalis

Symptoms & Phenotypes for Alopecia Totalis

Human phenotypes related to Alopecia Totalis:

59 32
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 alopecia 59 Very frequent (99-80%)
2 scalp hair loss 59 Very frequent (99-80%)
3 alopecia of scalp 32 hallmark (90%) HP:0002293

Drugs & Therapeutics for Alopecia Totalis

Drugs for Alopecia Totalis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 52)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydroxychloroquine Approved Phase 4 118-42-3 3652
2
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
3
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
4 Orange Approved, Nutraceutical Phase 4
5 Prednisolone acetate Phase 4
6 glucocorticoids Phase 4
7 Methylprednisolone acetate Phase 4
8 Methylprednisolone Hemisuccinate Phase 4
9 Gastrointestinal Agents Phase 4
10 Neuroprotective Agents Phase 4
11 Hormone Antagonists Phase 4
12 Hormones Phase 4
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
14 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Not Applicable
15 Prednisolone hemisuccinate Phase 4
16 Prednisolone phosphate Phase 4
17 Anti-Infective Agents Phase 4,Phase 2,Not Applicable
18 Antiemetics Phase 4
19 Protective Agents Phase 4,Phase 2,Phase 3
20 Antiparasitic Agents Phase 4
21 Antiprotozoal Agents Phase 4
22 Anti-Inflammatory Agents Phase 4,Not Applicable
23 Antimalarials Phase 4
24 Antirheumatic Agents Phase 4,Phase 2,Not Applicable
25 Autonomic Agents Phase 4
26 Antineoplastic Agents, Hormonal Phase 4
27
Acetylcholine Approved Phase 2, Phase 3 51-84-3 187
28
Bexarotene Approved, Investigational Phase 2, Phase 3 153559-49-0 82146
29 abobotulinumtoxinA Phase 2, Phase 3
30 Cholinergic Agents Phase 2, Phase 3
31 Neuromuscular Agents Phase 2, Phase 3
32 Neurotransmitter Agents Phase 2, Phase 3
33 onabotulinumtoxinA Phase 2, Phase 3
34 Botulinum Toxins, Type A Phase 2, Phase 3
35 Botulinum Toxins Phase 2, Phase 3
36
Cidofovir Approved Phase 2 113852-37-2 60613
37
Tofacitinib Approved, Investigational Phase 2,Not Applicable 477600-75-2
38
Abatacept Approved Phase 2 332348-12-6 10237
39 Protein Kinase Inhibitors Phase 2,Not Applicable
40 Antiviral Agents Phase 2
41 Antibodies Phase 2
42 Immunoglobulins Phase 2
43 Antibodies, Monoclonal Phase 2
44 Pharmaceutical Solutions Phase 2
45 Immunosuppressive Agents Phase 2,Not Applicable
46
Apremilast Approved, Investigational Not Applicable 608141-41-9 11561674
47 Analgesics Not Applicable
48 Analgesics, Non-Narcotic Not Applicable
49 Angiogenesis Inhibitors Not Applicable
50 Angiogenesis Modulating Agents Not Applicable

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 Plaquenil for Alopecia Areata, Alopecia Totalis Completed NCT00176982 Phase 4 Hydroxychloroquine
2 Safety and Efficacy of Oral Mega Pulse Methylprednisolone in Severe Therapy Resistant Alopecia Areata Completed NCT01167946 Phase 4 methylprednisolone sodium succinate;methylprednisolone sodium succinate;methylprednisolone sodium succinate
3 The Randomized Double-blind Placebo-controlled Trial of Intralesional Botulinum Toxin A Injection for Recalcitrant Alopecia Totalis and Alopecia Universalis Completed NCT00997815 Phase 2, Phase 3 Botulinum toxin A;Normal saline injection
4 Phase II Randomized Bilateral Comparison of Topical Targretin Gel 1% in Alopecia Areata Completed NCT00063076 Phase 2, Phase 3 Targretin Gel 1%
5 Tofacitnib for the Treatment of Alopecia Areata and Variants Completed NCT02197455 Phase 2 Tofacitinib Administration
6 Trial of Topical Cidofovir for the Prevention of Hair Growth Completed NCT00948506 Phase 2 1% topical cidofovir;3% topical cidofovir;Placebo
7 Open Label Study of ATI-50002 Topical Solution Administered to Adult Subjects With Eyebrow Loss Due to Alopecia Areata Recruiting NCT03551821 Phase 2 ATI-50002
8 A Pilot Study of Tralokinumab in Subjects With Moderate to Severe Alopecia Areata Recruiting NCT02684097 Phase 2 Tralokinumab;Placebo
9 Treatment of Alopecia Areata (AA) With Dupilumab in Patients With and Without Atopic Dermatitis (AD) Recruiting NCT03359356 Phase 2 Dupilumab;Placebos
10 Safety and Pharmacokinetic Study of ATI-50002 in Subjects With Alopecia Universalis (AU) and Alopecia Totalis (AT) Active, not recruiting NCT03315689 Phase 2 Vehicle;ATI-50002
11 Topical Tofacitinib for the Treatment of Alopecia Areata and Its Variants Active, not recruiting NCT02812342 Phase 2 Tofacitinib ointment
12 Study To Evaluate The Efficacy Of Tofacitinib In Moderate To Severe Alopecia Areata, Totalis And Universalis Active, not recruiting NCT02299297 Phase 2 Tofacitinib
13 An Open-Label Single-Arm Clinical Trial to Evaluate The Efficacy of Abatacept in Moderate to Severe Patch Type Alopecia Areata Active, not recruiting NCT02018042 Phase 2 Abatacept
14 Phase 2 Trial of BNZ-1 in Patients With Moderate to Severe Alopecia Areata Not yet recruiting NCT03532958 Phase 2 BNZ-1;Normal saline
15 Efficacy of Topical Gentamycin for Hereditary Hypotrichosis Simplex Caused by Nonsense Mutations in CDSN Not yet recruiting NCT03492866 Phase 2 Gentamicin Sulfate
16 A Study of Secukinumab for the Treatment of Alopecia Areata Terminated NCT02599129 Phase 2 Secukinumab;Placebo
17 A Study With INCB018424 Phosphate Cream Applied Topically to Subjects With Alopecia Areata (AA) Terminated NCT02553330 Phase 2 Placebo Cream;INCB018424 Phosphate Cream
18 Abatacept Costimulatory Blockade in the Treatment of Alopecia Totalis/Universalis Withdrawn NCT01314495 Phase 2 Abatacept;Inactive infusion
19 Efalizumab in the Treatment of Alopecia, Phase II Withdrawn NCT00746980 Phase 2 efalizumab
20 Tofacitinib for the Treatment of Alopecia Areata and Its Variants Completed NCT02312882 Not Applicable Tofacitinib
21 Alopecia Areata Registry Active, not recruiting NCT00069589
22 Pilot Study of the Safety and Efficacy of Apremilast in Subjects With Moderate to Severe Alopecia Areata Active, not recruiting NCT02684123 Not Applicable Apremilast;Placebo
23 Ocular Finding in Alopecia Areata Not yet recruiting NCT03155958

Search NIH Clinical Center for Alopecia Totalis

Genetic Tests for Alopecia Totalis

Anatomical Context for Alopecia Totalis

MalaCards organs/tissues related to Alopecia Totalis:

41
Skin, Thyroid, Testes, Bone, Bone Marrow

Publications for Alopecia Totalis

Articles related to Alopecia Totalis:

(show top 50) (show all 71)
# Title Authors Year
1
Is methotrexate an effective and safe treatment for maintaining hair regrowth in people with alopecia totalis? A critically appraised topic. ( 29777625 )
2018
2
Topical 2% tofacitinib for children with alopecia areata, alopecia totalis, and alopecia universalis. ( 29754888 )
2018
3
Risk of sun-induced skin cancers in patients with alopecia areata, alopecia totalis and alopecia universalis. ( 29679494 )
2018
4
Multi-Concentration Level Patch Test Guided Diphenyl Cyclopropenone (DPCP) Treatment in Alopecia Totalis or Alopecia Universalis. ( 29911776 )
2017
5
Review of treatment for alopecia totalis and alopecia universalis. ( 28378336 )
2017
6
Long-Term Prognosis of Alopecia Totalis and Alopecia Universalis: A Longitudinal Study with More than 10 Years of Follow-Up: Better than Reported. ( 28704810 )
2017
7
Hydroxychloroquine is ineffective in treatment of alopecia totalis and extensive alopecia areata: A case series of 8 patients. ( 27051848 )
2016
8
Treatment of corticosteroid-refractory alopecia totalis with oral tacrolimus. ( 27826988 )
2016
9
Pulse corticosteroid therapy with oral dexamethasone for the treatment of adult alopecia totalis and universalis. ( 27085229 )
2016
10
Nail lichen planus in a patient with alopecia totalis. ( 25526340 )
2014
11
Persistent and diffuse hair graying after recovery from alopecia totalis. ( 22591311 )
2014
12
Alopecia totalis in monosomy 18p. ( 24413381 )
2014
13
Recurrent spontaneous abortions, Hashimoto thyroiditis and alopecia totalis: response to anticoagulation and intravenous immunoglobulin therapy. ( 24308767 )
2014
14
Hepatitis C treatment and alopecia totalis. ( 24326562 )
2013
15
Successful treatment of alopecia totalis with hydroxychloroquine: report of 2 cases. ( 23680203 )
2013
16
Clinical characteristics and prognostic factors in early-onset alopecia totalis and alopecia universalis. ( 22787378 )
2012
17
Chronic inflammatory demyelinating polyneuropathy associated with alopecia totalis and SjAPgren syndrome. ( 22499108 )
2012
18
Photodynamic therapy with methyl 5-aminolevulinate acid might be ineffective in recalcitrant alopecia totalis regardless of using a microneedle roller to increase skin penetration. ( 20384755 )
2010
19
Turban PUVASOL: An Effective Treatment in Alopecia Totalis. ( 21712898 )
2010
20
Primary hypergonadotrophic hypogonadism, alopecia totalis, and mA1llerian hypoplasia: a clinical study. ( 19757710 )
2009
21
The effect of methylprednisolone pulse-therapy plus oral cyclosporine in the treatment of alopecia totalis and universalis. ( 18154427 )
2008
22
The use of methotrexate alone or in combination with low doses of oral corticosteroids in the treatment of alopecia totalis or universalis. ( 17010743 )
2006
23
Acute alopecia totalis. ( 16850096 )
2006
24
Alopecia totalis incognito. ( 15569019 )
2004
25
Clobetasol propionate 0.05% under occlusion in the treatment of alopecia totalis/universalis. ( 12833016 )
2003
26
Ineffectiveness of imiquimod therapy for Alopecia Totalis/Universalis. ( 12224709 )
2002
27
Antibodies against hair follicles are associated with alopecia totalis in autoimmune polyendocrine syndrome type I. ( 10594751 )
1999
28
The genetic basis of alopecia areata: HLA associations with patchy alopecia areata versus alopecia totalis and alopecia universalis. ( 10674369 )
1999
29
Syndrome of alopecia totalis and 17b-hydroxysteroid dehydrogenase deficiency. ( 9508060 )
1998
30
Myasthenia gravis with alopecia totalis. ( 9583214 )
1998
31
Alopecia totalis treated with oral mini-pulse (OMP) therapy with betamethasone. ( 20947995 )
1996
32
Long-term results of topical immunotherapy in children with alopecia totalis or alopecia universalis. ( 8708020 )
1996
33
HLA class II alleles in long-standing alopecia totalis/alopecia universalis and long-standing patchy alopecia areata differentiate these two clinical groups. ( 7738393 )
1995
34
Alopecia totalis and topical mustine. ( 8466230 )
1993
35
Treatment of alopecia totalis with a combination of inosine pranobex and diphencyprone compared to each treatment alone. ( 1718636 )
1991
36
Alopecia totalis: is treating nonresponder patients useful? ( 2061445 )
1991
37
Alopecia totalis and vitiligo in common variable immunodeficiency. ( 2062780 )
1991
38
Thyroid antibodies in alopecia totalis. ( 1813129 )
1991
39
Simultaneous primary infection with HIV and CMV leading to severe pancytopenia, hepatitis, nephritis, perimyocarditis, myositis, and alopecia totalis. ( 2156107 )
1990
40
Successful bone marrow transplant and re-growth of hair in a patient with posthepatic aplastic anemia complicated by alopecia totalis. ( 2126659 )
1990
41
Allergic and irritant contact dermatitis compared in the treatment of alopecia totalis and universalis. A comparison of the value of topical diphencyprone and tretinoin gel. ( 2713259 )
1989
42
Alopecia totalis in a patient with Crohn's disease and its treatment with azathioprine. ( 2813243 )
1989
43
Induction of hair growth in alopecia totalis with diphencyprone sensitization. ( 2598490 )
1989
44
A randomized double-blind study of inosiplex (isoprinosine) therapy in patients with alopecia totalis. ( 2438319 )
1987
45
Alopecia totalis in a chimpanzee. ( 6502684 )
1984
46
An open-label trial of immunomodulation therapy with inosiplex (Isoprinosine) in patients with alopecia totalis and cell-mediated immunodeficiency. ( 6207216 )
1984
47
Alopecia totalis as a presentation of cutaneous metastasis (alopecia neoplastica). ( 6642837 )
1983
48
PUVA treatment of alopecia totalis. ( 6198849 )
1983
49
The emotional disturbance underlying alopecia areata, alopecia totalis and trichotillomania. ( 527390 )
1979
50
Corticosteroids in the treatment of alopecia totalis. Systemic effects. ( 718184 )
1978

Variations for Alopecia Totalis

Expression for Alopecia Totalis

Search GEO for disease gene expression data for Alopecia Totalis.

Pathways for Alopecia Totalis

GO Terms for Alopecia Totalis

Sources for Alopecia Totalis

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69 SNOMED-CT via HPO
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74 UMLS via Orphanet
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