MCID: ALP005
MIFTS: 23

Alpha Chain Disease

Categories: Gastrointestinal diseases, Immune diseases

Aliases & Classifications for Alpha Chain Disease

MalaCards integrated aliases for Alpha Chain Disease:

Name: Alpha Chain Disease 12 15
Immunoproliferative Small Intestinal Disease 74
Seligmann's Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060126
UMLS 74 C0021071

Summaries for Alpha Chain Disease

Disease Ontology : 12 A heavy chain disease that results from an overproduction of alpha antibodies (IgA).

MalaCards based summary : Alpha Chain Disease, also known as immunoproliferative small intestinal disease, is related to lymphoma and intestinal disease, and has symptoms including fever, abdominal pain and diarrhea. An important gene associated with Alpha Chain Disease is JCHAIN (Joining Chain Of Multimeric IgA And IgM). Affiliated tissues include small intestine, bone and colon.

Related Diseases for Alpha Chain Disease

Diseases in the Mu Chain Disease family:

Alpha Chain Disease Delta Chain Disease

Diseases related to Alpha Chain Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 lymphoma 10.4
2 intestinal disease 10.0
3 alpha-heavy chain disease 10.0
4 small intestine lymphoma 9.9
5 immunoglobulin a deficiency 1 9.7
6 heavy chain disease 9.7
7 gamma heavy chain disease 9.7
8 schistosomiasis 9.7
9 coccidiosis 9.7
10 plasmacytoma 9.7
11 toxoplasmosis 9.7

Graphical network of the top 20 diseases related to Alpha Chain Disease:



Diseases related to Alpha Chain Disease

Symptoms & Phenotypes for Alpha Chain Disease

UMLS symptoms related to Alpha Chain Disease:


fever, abdominal pain, diarrhea

Drugs & Therapeutics for Alpha Chain Disease

Search Clinical Trials , NIH Clinical Center for Alpha Chain Disease

Genetic Tests for Alpha Chain Disease

Anatomical Context for Alpha Chain Disease

MalaCards organs/tissues related to Alpha Chain Disease:

42
Small Intestine, Bone, Colon, T Cells, B Cells, Lymph Node, Bone Marrow

Publications for Alpha Chain Disease

Articles related to Alpha Chain Disease:

(show top 50) (show all 178)
# Title Authors Year
1
Alpha-chain disease: a lymphomagenesis model. ( 29976467 )
2018
2
Recurrent diarrhoea in a renal transplant recipient: Early immunoproliferative small intestinal disease may be missed if not considered. ( 28205353 )
2017
3
Immunoproliferative Small Intestinal Disease Associated with Overwhelming Polymicrobial Gastrointestinal Infection with Transformation to Diffuse Large B-cell Lymphoma. ( 26903604 )
2016
4
Campylobacter coli cultured from the stools of a patient with immunoproliferative small intestinal disease. ( 24438451 )
2014
5
Draft Genome Sequence of Campylobacter coli Strain IPSID-1 Isolated from a Patient with Immunoproliferative Small Intestinal Disease. ( 24625865 )
2014
6
Immunoproliferative small intestinal disease: a report of 6 cases. ( 26349179 )
2014
7
Immunoproliferative small intestinal disease presented with ascites and edema. ( 24558774 )
2013
8
Capsule-endoscopic findings in immunoproliferative small-intestinal disease. ( 22396282 )
2012
9
A rare cause of lymphadenopathy near the terminal ileum: immunoproliferative small intestinal disease. ( 22505392 )
2012
10
Immunoproliferative small intestinal disease associated with Campylobacter jejuni. ( 22552252 )
2012
11
Immunoproliferative small intestinal disease (IPSID). ( 21276391 )
2011
12
Immunoproliferative small intestinal disease-a rare extranodal marginal zone lymphoma of mucosa associated lymphoid tissue in the Indian subcontinent. ( 27365825 )
2011
13
Regression of immunoproliferative small intestinal disease after eradication of Helicobacter pylori. ( 20300878 )
2010
14
Immunoproliferative small intestinal disease versus colonic monoblastic sarcoma in a 2-year-old boy. ( 19942975 )
2009
15
Immunoproliferative small intestinal disease with protein loss complicated with duodenal T cell lymphoma during progression. ( 18277034 )
2008
16
Roles of syndecan-1, bcl6 and p53 in diagnosis and prognostication of immunoproliferative small intestinal disease. ( 16773719 )
2006
17
Immunoproliferative small intestinal disease in Greece: presentation of 13 cases including two from Albania. ( 16894320 )
2006
18
Immunoproliferative small intestinal disease (IPSID): a model for mature B-cell neoplasms. ( 15542584 )
2005
19
Nonsecretory variant of immunoproliferative small intestinal disease: a case report with pathologic, immunophenotypic, and molecular findings. ( 16253033 )
2005
20
Immunoproliferative small intestinal disease: current concepts. ( 16259867 )
2005
21
Immunoproliferative small intestinal disease associated with Campylobacter jejuni. ( 14724303 )
2004
22
Immunoproliferative small intestinal disease associated with Campylobacter jejuni. ( 15084705 )
2004
23
Re: Lin and Gray - immunoproliferative small intestinal disease. ( 12591078 )
2003
24
Lymphomatous category of immunoproliferative small intestinal disease. ( 14616957 )
2003
25
Immunoproliferative small intestinal disease, two cases in the Northern Territory. ( 11783675 )
2002
26
Malabsorption syndrome in a patient of Mediterranean origin; immunoproliferative small intestinal disease. ( 11334682 )
2001
27
Is immunoproliferative small intestinal disease uncommon in India? ( 11398237 )
2001
28
Immunoproliferative small intestinal disease: prolonged 30-year course without development of lymphoma. ( 11569710 )
2001
29
Immunoproliferative small intestinal disease. ( 10710112 )
2000
30
Alpha-heavy chain disease, Mediterranean lymphoma, and immunoproliferative small intestinal disease: a review of clinicopathological features, pathogenesis, and differential diagnosis. ( 10235185 )
1999
31
Primary low-grade lymphomas of the intestine. Case 1: immunoproliferative small intestinal disease. ( 10550167 )
1999
32
Immunoproliferative small intestinal disease: case report and literature review. ( 10826015 )
1999
33
Pigmented nails and Strongyloides stercoralis infestation causing clinical worsening in a patient treated for immunoproliferative small intestinal disease: two unusual observations. ( 10892497 )
1999
34
Immunoproliferative small intestinal disease in a 16-year-old boy presenting as severe malabsorption with excellent response to tetracycline treatment. ( 9706780 )
1998
35
Immunoproliferative small intestinal disease in South India: a clinical and immunomorphological study. ( 9918427 )
1998
36
T-cell rich alpha-chain disease mimicking T-cell lymphoma. ( 9147095 )
1997
37
Regression of immunoproliferative small intestinal disease after eradication of Helicobacter pylori. ( 8988128 )
1997
38
Immunoproliferative small intestinal disease (IPSID): the Indian scenario. ( 9167388 )
1997
39
Five-year results of the treatment of 23 patients with immunoproliferative small intestinal disease: a Turkish experience. ( 9210703 )
1997
40
Immunoproliferative small intestinal disease and primary small intestinal lymphoma: review of literature. ( 9339621 )
1997
41
Immunoproliferative small intestinal disease: a frequently missed diagnosis. ( 8935933 )
1996
42
Non-secretory alpha chain disease involving stomach, small intestine and colon. ( 7606093 )
1995
43
Malabsorption associated with a high-grade-malignant non-Hodgkin's lymphoma, alpha-heavy-chain disease and immunoproliferative small intestinal disease. ( 7793120 )
1995
44
Clinicopathological features and management of immunoproliferative small intestinal disease and primary small intestinal lymphoma in Pakistan. ( 7674998 )
1995
45
Combination chemotherapy with tetracycline and aggressive supportive care for immunoproliferative small-intestinal disease lymphoma. ( 7884437 )
1995
46
Immunoproliferative small intestinal disease: Mediterranean lymphoma and alpha heavy chain disease. ( 8313111 )
1994
47
Primary small-intestinal lymphomas in Taiwan: immunoproliferative small-intestinal disease and nonimmunoproliferative small-intestinal disease. ( 8021727 )
1994
48
Latent Epstein-Barr virus infection is an unlikely event in the pathogenesis of immunoproliferative small intestinal disease. ( 8082070 )
1994
49
Immunoproliferative small intestinal disease in Mexico. Report of four cases and review of the literature. ( 8113590 )
1994
50
Alpha-chain disease: analysis of alpha-chain protein and secretory component in jejunal fluid. ( 8419251 )
1993

Variations for Alpha Chain Disease

Expression for Alpha Chain Disease

Search GEO for disease gene expression data for Alpha Chain Disease.

Pathways for Alpha Chain Disease

GO Terms for Alpha Chain Disease

Sources for Alpha Chain Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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