MCID: ALP005
MIFTS: 31

Alpha Chain Disease

Categories: Immune diseases, Gastrointestinal diseases

Aliases & Classifications for Alpha Chain Disease

MalaCards integrated aliases for Alpha Chain Disease:

Name: Alpha Chain Disease 12 15
Immunoproliferative Small Intestinal Disease 73
Seligmann's Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060126
UMLS 73 C0021071

Summaries for Alpha Chain Disease

Disease Ontology : 12 A heavy chain disease that results from an overproduction of alpha antibodies (IgA).

MalaCards based summary : Alpha Chain Disease, also known as immunoproliferative small intestinal disease, is related to heavy chain disease and immunoglobulin a deficiency 1, and has symptoms including abdominal pain, diarrhea and fever. An important gene associated with Alpha Chain Disease is CD79A (CD79a Molecule), and among its related pathways/superpathways are Calcineurin-regulated NFAT-dependent transcription in lymphocytes and Primary immunodeficiency. Affiliated tissues include small intestine, colon and t cells.

Related Diseases for Alpha Chain Disease

Diseases in the Mu Chain Disease family:

Alpha Chain Disease Delta Chain Disease

Diseases related to Alpha Chain Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 164)
# Related Disease Score Top Affiliating Genes
1 heavy chain disease 29.7 CD40LG CD79A
2 immunoglobulin a deficiency 1 29.7 CD40LG CD79A
3 coccidiosis 29.6 CD40LG CD79A
4 hypersensitivity reaction type iv disease 29.5 CD40LG CD79A
5 toxoplasmosis 29.3 CD40LG CD79A
6 schistosomiasis 29.3 CD40LG CD79A
7 gamma heavy chain disease 28.8 CD40LG CD79A SLC3A2
8 lymphoma 10.3
9 selective igg deficiency disease 10.3 CD40LG CD79A
10 c1q nephropathy 10.3 CD40LG CD79A
11 meningovascular neurosyphilis 10.2 CD40LG CD79A
12 brill-zinsser disease 10.2 CD40LG CD79A
13 exudative glomerulonephritis 10.2 CD40LG CD79A
14 cork-handlers' disease 10.2 CD40LG CD79A
15 salpingo-oophoritis 10.2 CD40LG CD79A
16 early yaws 10.2 CD40LG CD79A
17 ventilation pneumonitis 10.2 CD40LG CD79A
18 chronic interstitial cystitis 10.2 CD40LG CD79A
19 axillary adenitis 10.2 CD40LG CD79A
20 cryofibrinogenemia 10.2 CD40LG CD79A
21 trichostrongyloidiasis 10.2 CD40LG CD79A
22 subacute bacterial endocarditis 10.2 CD40LG CD79A
23 heterophyiasis 10.2 CD40LG CD79A
24 immunoglobulin g deficiency 10.2 CD40LG CD79A
25 orbital granuloma 10.2 CD40LG CD79A
26 transient hypogammaglobulinemia of infancy 10.2 CD40LG CD79A
27 hyperglobulinemic purpura 10.2 CD40LG CD79A
28 gastroduodenitis 10.2 CD40LG CD79A
29 bacterial conjunctivitis 10.2 CD40LG CD79A
30 ophthalmia neonatorum 10.2 CD40LG CD79A
31 parotid disease 10.2 CD40LG CD79A
32 cerebral arteritis 10.2 CD40LG CD79A
33 selective immunoglobulin deficiency disease 10.2 CD40LG CD79A
34 geniculate herpes zoster 10.2 CD40LG CD79A
35 erythema elevatum diutinum 10.2 CD40LG CD79A
36 sporotrichosis 10.2 CD40LG CD79A
37 fallopian tube disease 10.2 CD40LG CD79A
38 hyperimmunoglobulin syndrome 10.2 CD40LG CD79A
39 congenital syphilis 10.2 CD40LG CD79A
40 polyclonal hypergammaglobulinemia 10.2 CD40LG CD79A
41 monoclonal paraproteinemia 10.2 CD40LG CD79A
42 salpingitis 10.2 CD40LG CD79A
43 ocular toxoplasmosis 10.2 CD40LG CD79A
44 dysgammaglobulinemia 10.2 CD40LG CD79A
45 congenital hypogammaglobulinemia 10.2 CD40LG CD79A
46 acute maxillary sinusitis 10.2 CD40LG CD79A
47 chronic polyneuropathy 10.2 CD40LG CD79A
48 spinocerebellar ataxia, autosomal recessive 10 10.2 CD40LG CD79A
49 parasitic ichthyosporea infectious disease 10.2 CD40LG CD79A
50 cd40 ligand deficiency 10.2 CD40LG CD79A

Graphical network of the top 20 diseases related to Alpha Chain Disease:



Diseases related to Alpha Chain Disease

Symptoms & Phenotypes for Alpha Chain Disease

UMLS symptoms related to Alpha Chain Disease:


abdominal pain, diarrhea, fever

Drugs & Therapeutics for Alpha Chain Disease

Search Clinical Trials , NIH Clinical Center for Alpha Chain Disease

Genetic Tests for Alpha Chain Disease

Anatomical Context for Alpha Chain Disease

MalaCards organs/tissues related to Alpha Chain Disease:

41
Small Intestine, Colon, T Cells, Testes, Bone Marrow, Lymph Node, Bone

Publications for Alpha Chain Disease

Articles related to Alpha Chain Disease:

(show top 50) (show all 99)
# Title Authors Year
1
Alpha-chain disease: a lymphomagenesis model. ( 29976467 )
2018
2
T-cell rich alpha-chain disease mimicking T-cell lymphoma. ( 9147095 )
1997
3
Non-secretory alpha chain disease involving stomach, small intestine and colon. ( 7606093 )
1995
4
Alpha-chain disease: analysis of alpha-chain protein and secretory component in jejunal fluid. ( 8419251 )
1993
5
Leukemic manifestation in a case of alpha-chain disease with multiple polypoid intestinal lymphocytic lymphoma. ( 1415195 )
1992
6
A case of lymphoma-type alpha-chain disease. ( 1950370 )
1991
7
Gene deletions force nonsecretory alpha-chain disease plasma cells to produce membrane-form alpha-chain only. ( 2120331 )
1990
8
Low serum transglutaminase in patients with intestinal lymphoma and alpha-chain disease. ( 1979203 )
1990
9
Immunoproliferative small intestinal disease (IPSID): relationships with alpha-chain disease and "Mediterranean" lymphomas. ( 2205943 )
1990
10
A case of alpha-chain disease. ( 2810318 )
1989
11
Nonsecretory alpha-chain disease with immunoproliferative small-intestinal disease. ( 2498659 )
1989
12
Cells expressing intracytoplasmic immunoglobulins in secreting and hyposecreting cases of alpha chain disease. ( 2518741 )
1989
13
Immunoproliferative small intestinal disease without alpha-chain disease: a pathological study. ( 2914638 )
1989
14
Treatment of alpha chain disease. Results of a prospective study in 21 Tunisian patients by the Tunisian-French intestinal Lymphoma Study Group. ( 2920354 )
1989
15
Affinity chromatography in the purification of alpha chain disease proteins. ( 3151750 )
1988
16
Abnormal protein hyposecretion in early and late course of alpha chain disease. ( 3151749 )
1988
17
Alpha-chain disease in children. ( 3335961 )
1988
18
A new form of alpha-chain disease with generalized lymph node involvement. ( 3222174 )
1988
19
Cytopathology of alpha chain disease involving the central nervous system and pleura. ( 2462320 )
1988
20
Clinical and pathological evolution of alpha chain disease to immunoblastic lymphoma and response to COMP chemotherapy. ( 3352536 )
1988
21
Alpha-chain disease. Report of a case from Taiwan. ( 3791162 )
1987
22
Cytogenetic studies in four cases of alpha chain disease. ( 3085916 )
1986
23
Gastric form of alpha chain disease. ( 3087826 )
1986
24
Immunoblastic lymphoma involving the bone marrow in a patient with alpha chain disease. Clinical and immunoelectron microscopic study. ( 3917845 )
1985
25
Long survival in a patient with alpha-chain disease. ( 6420038 )
1984
26
Immunoproliferative small intestinal disease in Algerians. II. Ultrastructural studies in alpha-chain disease. ( 6434178 )
1984
27
Atypical plasma cells in alpha-chain disease. ( 6406038 )
1983
28
Spectrum of alpha chain disease in India. ( 6439623 )
1983
29
Alpha-chain disease without qualitative serum IgA abnormality. Report of two cases, including a "nonsecretory" form. ( 6401593 )
1983
30
Alpha-chain disease: an immunoproliferative disease of the secretory immune system. ( 6408973 )
1983
31
Small intestinal lymphomas and alpha-chain disease. ( 6413104 )
1983
32
A comparison of several immunochemical approaches for the screening of alpha chain disease. ( 6437724 )
1983
33
Diffuse abdominal accumulation of Ga-67 citrate in a patient with alpha-chain disease. ( 6813121 )
1982
34
Alpha chain disease in the Thai man. ( 6810474 )
1982
35
Malignant alpha chain disease and exposure to asbestos. ( 6802636 )
1982
36
Changing morphological spectrum of alpha chain disease--a case report. ( 6809601 )
1982
37
Colonic lymphoma producing alpha-chain disease protein. ( 6804299 )
1982
38
Alpha-chain disease diagnosed by rectal biopsy. ( 6773611 )
1980
39
Immunochemical study in two cases of alpha chain disease. ( 6162743 )
1980
40
Atypical intestinal alpha-chain disease evolving into selective immunoglobulin a deficiency in a Finnish boy. ( 6777236 )
1980
41
Alpha chain disease of the stomach. ( 6780439 )
1980
42
Non-secretory alpha-chain disease in intestinal lymphoma. ( 6769044 )
1980
43
Alpha-chain disease, schistosomiasis and toxoplasmosis: a case report in Brazil and follow-up for 5 years. ( 6788026 )
1980
44
Alpha-chain disease in India. ( 6782070 )
1980
45
Alpha-chain disease: a diagnostic test? ( 87892 )
1979
46
Alpha-chain disease--a report of eleven patients from Iran. ( 119056 )
1979
47
Immunodiagnosis of alpha chain disease. ( 113152 )
1979
48
Lymphocytes subpopulation in normal family members of patients with alpha-chain disease. ( 109705 )
1979
49
Malignant potential of intestinal plasma cells in alpha-chain disease. ( 84179 )
1979
50
Middle East lymphoma and alpha-chain disease. An immunohistochemical study. ( 119442 )
1979

Variations for Alpha Chain Disease

Expression for Alpha Chain Disease

Search GEO for disease gene expression data for Alpha Chain Disease.

Pathways for Alpha Chain Disease

Pathways related to Alpha Chain Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.84 CD40LG SLC3A2
2 10.19 CD40LG CD79A

GO Terms for Alpha Chain Disease

Biological processes related to Alpha Chain Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 B cell differentiation GO:0030183 8.96 CD40LG CD79A
2 B cell proliferation GO:0042100 8.62 CD40LG CD79A

Sources for Alpha Chain Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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