MCID: ALP005
MIFTS: 27

Alpha Chain Disease

Categories: Gastrointestinal diseases, Immune diseases

Aliases & Classifications for Alpha Chain Disease

MalaCards integrated aliases for Alpha Chain Disease:

Name: Alpha Chain Disease 12 15
Immunoproliferative Small Intestinal Disease 73
Seligmann's Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060126
UMLS 73 C0021071

Summaries for Alpha Chain Disease

Disease Ontology : 12 A heavy chain disease that results from an overproduction of alpha antibodies (IgA).

MalaCards based summary : Alpha Chain Disease, also known as immunoproliferative small intestinal disease, is related to lymphoma and intestinal disease, and has symptoms including fever, abdominal pain and diarrhea. An important gene associated with Alpha Chain Disease is JCHAIN (Joining Chain Of Multimeric IgA And IgM), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Cell surface interactions at the vascular wall. Affiliated tissues include small intestine, bone and colon, and related phenotype is digestive/alimentary.

Related Diseases for Alpha Chain Disease

Diseases in the Mu Chain Disease family:

Alpha Chain Disease Delta Chain Disease

Diseases related to Alpha Chain Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 lymphoma 10.3
2 intestinal disease 10.0
3 alpha-heavy chain disease 10.0
4 mu chain disease 9.7 JCHAIN SLC3A2
5 immunoglobulin a deficiency 1 9.7
6 heavy chain disease 9.7
7 gamma heavy chain disease 9.7
8 schistosomiasis 9.7
9 coccidiosis 9.7
10 plasmacytoma 9.7
11 toxoplasmosis 9.7

Graphical network of the top 20 diseases related to Alpha Chain Disease:



Diseases related to Alpha Chain Disease

Symptoms & Phenotypes for Alpha Chain Disease

UMLS symptoms related to Alpha Chain Disease:


fever, abdominal pain, diarrhea

MGI Mouse Phenotypes related to Alpha Chain Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 8.62 JCHAIN SLC3A2

Drugs & Therapeutics for Alpha Chain Disease

Search Clinical Trials , NIH Clinical Center for Alpha Chain Disease

Genetic Tests for Alpha Chain Disease

Anatomical Context for Alpha Chain Disease

MalaCards organs/tissues related to Alpha Chain Disease:

41
Small Intestine, Bone, Colon, T Cells, Testes, Lymph Node, Bone Marrow

Publications for Alpha Chain Disease

Articles related to Alpha Chain Disease:

(show top 50) (show all 106)
# Title Authors Year
1
Alpha-chain disease: a lymphomagenesis model. ( 29976467 )
2018
2
Immunoproliferative small intestinal disease-a rare extranodal marginal zone lymphoma of mucosa associated lymphoid tissue in the Indian subcontinent. ( 27365825 )
2011
3
T-cell rich alpha-chain disease mimicking T-cell lymphoma. ( 9147095 )
1997
4
Non-secretory alpha chain disease involving stomach, small intestine and colon. ( 7606093 )
1995
5
Latent Epstein-Barr virus infection is an unlikely event in the pathogenesis of immunoproliferative small intestinal disease. ( 8082070 )
1994
6
Alpha-chain disease: analysis of alpha-chain protein and secretory component in jejunal fluid. ( 8419251 )
1993
7
Leukemic manifestation in a case of alpha-chain disease with multiple polypoid intestinal lymphocytic lymphoma. ( 1415195 )
1992
8
A case of lymphoma-type alpha-chain disease. ( 1950370 )
1991
9
Gene deletions force nonsecretory alpha-chain disease plasma cells to produce membrane-form alpha-chain only. ( 2120331 )
1990
10
Low serum transglutaminase in patients with intestinal lymphoma and alpha-chain disease. ( 1979203 )
1990
11
Immunoproliferative small intestinal disease (IPSID): relationships with alpha-chain disease and "Mediterranean" lymphomas. ( 2205943 )
1990
12
A case of alpha-chain disease. ( 2810318 )
1989
13
Nonsecretory alpha-chain disease with immunoproliferative small-intestinal disease. ( 2498659 )
1989
14
Cells expressing intracytoplasmic immunoglobulins in secreting and hyposecreting cases of alpha chain disease. ( 2518741 )
1989
15
Immunoproliferative small intestinal disease without alpha-chain disease: a pathological study. ( 2914638 )
1989
16
Treatment of alpha chain disease. Results of a prospective study in 21 Tunisian patients by the Tunisian-French intestinal Lymphoma Study Group. ( 2920354 )
1989
17
Affinity chromatography in the purification of alpha chain disease proteins. ( 3151750 )
1988
18
Abnormal protein hyposecretion in early and late course of alpha chain disease. ( 3151749 )
1988
19
Alpha-chain disease in children. ( 3335961 )
1988
20
A new form of alpha-chain disease with generalized lymph node involvement. ( 3222174 )
1988
21
Cytopathology of alpha chain disease involving the central nervous system and pleura. ( 2462320 )
1988
22
Clinical and pathological evolution of alpha chain disease to immunoblastic lymphoma and response to COMP chemotherapy. ( 3352536 )
1988
23
Alpha-chain disease. Report of a case from Taiwan. ( 3791162 )
1987
24
Immunoproliferative small-intestinal disease: clinical features and outcome in 30 cases. ( 3683173 )
1987
25
Cytogenetic studies in four cases of alpha chain disease. ( 3085916 )
1986
26
Gastric form of alpha chain disease. ( 3087826 )
1986
27
Immunoblastic lymphoma involving the bone marrow in a patient with alpha chain disease. Clinical and immunoelectron microscopic study. ( 3917845 )
1985
28
Long survival in a patient with alpha-chain disease. ( 6420038 )
1984
29
Immunoproliferative small intestinal disease in Algerians. II. Ultrastructural studies in alpha-chain disease. ( 6434178 )
1984
30
Atypical plasma cells in alpha-chain disease. ( 6406038 )
1983
31
Spectrum of alpha chain disease in India. ( 6439623 )
1983
32
Alpha-chain disease without qualitative serum IgA abnormality. Report of two cases, including a "nonsecretory" form. ( 6401593 )
1983
33
Alpha-chain disease: an immunoproliferative disease of the secretory immune system. ( 6408973 )
1983
34
Small intestinal lymphomas and alpha-chain disease. ( 6413104 )
1983
35
A comparison of several immunochemical approaches for the screening of alpha chain disease. ( 6437724 )
1983
36
Diffuse abdominal accumulation of Ga-67 citrate in a patient with alpha-chain disease. ( 6813121 )
1982
37
Alpha chain disease in the Thai man. ( 6810474 )
1982
38
Malignant alpha chain disease and exposure to asbestos. ( 6802636 )
1982
39
Changing morphological spectrum of alpha chain disease--a case report. ( 6809601 )
1982
40
Colonic lymphoma producing alpha-chain disease protein. ( 6804299 )
1982
41
Alpha-chain disease diagnosed by rectal biopsy. ( 6773611 )
1980
42
Immunochemical study in two cases of alpha chain disease. ( 6162743 )
1980
43
Atypical intestinal alpha-chain disease evolving into selective immunoglobulin a deficiency in a Finnish boy. ( 6777236 )
1980
44
Alpha chain disease of the stomach. ( 6780439 )
1980
45
Non-secretory alpha-chain disease in intestinal lymphoma. ( 6769044 )
1980
46
Alpha-chain disease, schistosomiasis and toxoplasmosis: a case report in Brazil and follow-up for 5 years. ( 6788026 )
1980
47
Alpha-chain disease in India. ( 6782070 )
1980
48
Endoscopic diagnosis of immunoproliferative small intestinal disease (IPSID). ( 7379761 )
1980
49
Alpha-chain disease: a diagnostic test? ( 87892 )
1979
50
Alpha-chain disease--a report of eleven patients from Iran. ( 119056 )
1979

Variations for Alpha Chain Disease

Expression for Alpha Chain Disease

Search GEO for disease gene expression data for Alpha Chain Disease.

Pathways for Alpha Chain Disease

Pathways related to Alpha Chain Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.03 JCHAIN SLC3A2
2
Show member pathways
10.88 JCHAIN SLC3A2

GO Terms for Alpha Chain Disease

Biological processes related to Alpha Chain Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 leukocyte migration GO:0050900 8.62 JCHAIN SLC3A2

Sources for Alpha Chain Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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