MCID: ALT003
MIFTS: 33

Alternating Exotropia

Categories: Neuronal diseases

Aliases & Classifications for Alternating Exotropia

MalaCards integrated aliases for Alternating Exotropia:

Name: Alternating Exotropia 12 15 70
Exotropia 44 70

Classifications:



External Ids:

Disease Ontology 12 DOID:1142
ICD9CM 34 378.15
MeSH 44 D005099
SNOMED-CT 67 194093000
ICD10 32 H50.15
UMLS 70 C0015310 C0152207

Summaries for Alternating Exotropia

MalaCards based summary : Alternating Exotropia, also known as exotropia, is related to esotropia and smith-fineman-myers syndrome. An important gene associated with Alternating Exotropia is MYT1L (Myelin Transcription Factor 1 Like). The drugs Acetylcholine and Neurotransmitter Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and cortex.

Related Diseases for Alternating Exotropia

Diseases related to Alternating Exotropia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 147)
# Related Disease Score Top Affiliating Genes
1 esotropia 11.2
2 smith-fineman-myers syndrome 11.1
3 monocular exotropia 11.1
4 elsahy-waters syndrome 10.9
5 focal facial dermal dysplasia 3, setleis type 10.9
6 intellectual developmental disorder, x-linked, syndromic, armfield type 10.9
7 lowry-maclean syndrome 10.9
8 miles-carpenter syndrome 10.9
9 monocular esotropia 10.9
10 suppression amblyopia 10.7
11 amblyopia 10.7
12 refractive error 10.6
13 anisometropia 10.4
14 myopia 10.4
15 exotropia 10.3
16 kearns-sayre syndrome 10.2
17 ifap syndrome 2 10.2
18 internuclear ophthalmoplegia 10.2
19 hypertropia 10.2
20 astigmatism 10.2
21 ptosis 10.2
22 accommodative esotropia 10.2
23 duane retraction syndrome 1 10.1
24 cerebral palsy 10.1
25 hypotropia 10.1
26 abnormal retinal correspondence 10.0
27 eye disease 10.0
28 monofixation syndrome 10.0
29 farsightedness 10.0
30 crouzon syndrome 10.0
31 hypertelorism 10.0
32 ocular dominance 10.0
33 congenital ptosis 10.0
34 cycloplegia 10.0
35 basilar artery occlusion 10.0
36 cataract 10.0
37 congenital nystagmus 10.0
38 47,xyy 10.0
39 strabismus 10.0
40 presbyopia 10.0
41 mechanical strabismus 10.0
42 pathologic nystagmus 10.0
43 anisocoria 9.9
44 torticollis 9.9
45 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.9
46 myasthenia gravis 9.9
47 retinitis pigmentosa 9.9
48 keratoconus 9.9
49 brown's tendon sheath syndrome 9.9
50 paralytic squint 9.9

Graphical network of the top 20 diseases related to Alternating Exotropia:



Diseases related to Alternating Exotropia

Symptoms & Phenotypes for Alternating Exotropia

Drugs & Therapeutics for Alternating Exotropia

Drugs for Alternating Exotropia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
2 Neurotransmitter Agents Phase 4
3 Pharmaceutical Solutions Phase 4
4 abobotulinumtoxinA Phase 4
5 Cholinergic Agents Phase 4
6 Botulinum Toxins, Type A Phase 4
7 Botulinum Toxins Phase 4
8
Epinephrine Approved, Vet_approved Phase 2, Phase 3 51-43-4 5816
9
Racepinephrine Approved Phase 2, Phase 3 329-65-7 838
10
Bupivacaine Approved, Investigational Phase 2, Phase 3 38396-39-3, 2180-92-9 2474
11 Anesthetics Phase 2, Phase 3
12 Epinephryl borate Phase 2, Phase 3
13 Anesthetics, Local Phase 2, Phase 3
14
Dopamine Approved 51-61-6, 62-31-7 681
15
Methamphetamine Approved, Illicit 537-46-2 10836
16 Central Nervous System Stimulants
17 Dopamine Agents
18 Dopamine Uptake Inhibitors
19 Sympathomimetics
20 Adrenergic Agents
21 Mydriatics

Interventional clinical trials:

(show all 35)
# Name Status NCT ID Phase Drugs
1 Surgery Associated to Intraoperative Botulinum Toxin A for Large Angle Horizontal Strabismus: a Pilot Study Completed NCT01460355 Phase 4 Botulinum Toxin Type A;saline solution
2 Comparison of Medial Rectus Resection and Plication in Exotropic Patients Unknown status NCT03768362 Phase 2, Phase 3
3 Bupivacaine Injection of Eye Muscles to Treat Strabismus Recruiting NCT01616108 Phase 2, Phase 3 Bupivacaine
4 Randomized Study of Non-surgical Treatment Versus Observation in Asian Children With Intermittent Exotropia Terminated NCT01267500 Phase 2
5 Comparison of the Changes of Lateral Rectus Muscle Insertion Measured With AS-OCT in Two Recession Surgeries Unknown status NCT02450162
6 Long-term Prospective Randomized Controlled Clinical Study on Surgical Treatment of Moderate Intermittent Exotropia Unknown status NCT02736526
7 The Analysis of Ocular Deviations Between Dominant and Non-dominant Eye Using Video-oculography (VOG) in Intermittent Exotropia Unknown status NCT03641040
8 Pilot Study of Office Based Vergence and Accommodative Therapy as Treatment of Intermittent Exotropia Unknown status NCT03321838
9 Protective Effect of Biodegradable Collagen Implant (Ologen) in Scleral Thinning After Strabismus Surgery Completed NCT02699580
10 Intermittent Exotropia Study 6: A Pilot Randomized Clinical Trial of Base-in Prism Spectacles for Intermittent Exotropia Completed NCT03998670
11 A Novel Dynamic Random-dot Stereopsis Assessment to Measure the Stereopsis in Intermittent Exotropia Completed NCT04152122
12 Pre and Post-operative Rectus Muscle Insertion Site Changing Using Anterior Segment Optical Coherence Tomography in Strabismus Patients Completed NCT02383381
13 Early Results of Slanted Recession of the Lateral Rectus Muscle for Intermittent Exotropia With Convergence Weakness; A Prospective Study Completed NCT02131792
14 A Novel Diagnostic Method for Exotropia Using Video-oculography Completed NCT03119311
15 Lateral Rectus Muscle Tendon Elongation by an Auto Graft From the Resected Medial Rectus Muscle as a Monocular Surgery for Large Angle Sensory Exotropia Completed NCT04286945
16 Treatment for Convergence Insufficiency Intermittent Exotropia; A Randomized Trial Completed NCT01435876
17 A Randomized Clinical Trial of Observation Versus Occlusion Therapy for Intermittent Exotropia Completed NCT01032330
18 A Pilot Randomized Clinical Trial of Overminus Spectacle Therapy for Intermittent Exotropia Completed NCT02223650
19 Basic Intermittent Exotropia; is the Axial Length of the Globe One of the Prognostic Factors for Overcorrection and Undercorrection After Binocular Surgery Completed NCT03153423
20 Investigation of the Effect of Oculo-Motor Exercises in Intermittent Exotropic Children Completed NCT03661476
21 Strabismus Surgery and Driving Ability Completed NCT02570555
22 Bilateral Lateral Rectus Recession Using Standard Tables Versus Bilateral Lateral Rectus Recession Using Modified Reduced Numbers in Intermittent Exotropia in Children Less Than 6 Years Old Recruiting NCT04308538
23 Improving Control of Alignment in Intermittent Exotropia Recruiting NCT04199871
24 A Clinical Trial of Observation Versus Controlled Intermittent Alternate Occlusion (CIAO) Therapy for Intermittent Exotropia Recruiting NCT02902887
25 Slanted Bilateral Lateral Rectus Recession Versus Conventional Bilateral Lateral Rectus Recession for Convergence Insufficiency Intermittent Exotropia in Children Recruiting NCT04064112
26 A Phase 4 Randomized, Single-blind Study to Evaluate the Multi-media Training(SJ-RS-WL2015)Software Rehabilitating Ability of Binocular Functions in Hospitalized Adolescent Patients With Intermittent Exotropia After Eye Surgery Active, not recruiting NCT04263103
27 A Randomized Trial of Bilateral Lateral Rectus Recession Versus Unilateral Lateral Rectus Recession With Medial Rectus Resection for Intermittent Exotropia Active, not recruiting NCT01032603
28 A Randomized Clinical Trial of Overminus Spectacle Therapy for Intermittent Exotropia Active, not recruiting NCT02807350
29 The Long-Term Efficacy of Overminus Lens Therapy in Intermittent Exotropia Active, not recruiting NCT03952702
30 Genetic Studies of Strabismus and Associated Disorders Not yet recruiting NCT04770519
31 A Randomized Clinical Trial of Part-time Patching Therapy on Improvement of Deviation Control in 3 to 8 Year-old Children With Intermittent Exotropia Not yet recruiting NCT03700632
32 Effect of Age at Time of Surgery on the Surgical Outcome After Bilateral Lateral Rectus Muscle Recession in Intermittent Exotropia Not yet recruiting NCT04307160
33 A Pilot Randomized Trial Evaluating Short-Term Effectiveness of Vision Therapy in Children With Intermittent Exotropia Not yet recruiting NCT04487249
34 Effectiveness of Office Based Vergence/Accommodative Therapy for the Treatment of Intermittent Exotropia: A Randomized Clinical Trial Not yet recruiting NCT04744779
35 A Clinical Trial of Observation Versus Controlled Intermittent Alternate Occlusion (CIAO) Therapy for Intermittent Exotropia Terminated NCT02466659

Search NIH Clinical Center for Alternating Exotropia

Cochrane evidence based reviews: exotropia

Genetic Tests for Alternating Exotropia

Anatomical Context for Alternating Exotropia

MalaCards organs/tissues related to Alternating Exotropia:

40
Eye, Bone, Cortex, Thyroid, Retina, Pons, Pineal

Publications for Alternating Exotropia

Articles related to Alternating Exotropia:

(show top 50) (show all 2391)
# Title Authors PMID Year
1
Surgical strategy for third nerve palsy with aberrant regeneration: Harnessing the aberrant power. 61
33727458 2021
2
[Long term outcomes of botulinum toxin injections in infantile esotropia]. 61
33632627 2021
3
Neurovascular compression of the oculomotor nerve presenting with aberrant reinnervation. 61
33426366 2021
4
Consecutive Esotropia with and without Abduction Limitation - Risk Factors and Surgical Outcomes of Lateral Rectus Advancement. 61
33783332 2021
5
Superior Rectus Transposition and Medial Rectus Recession for Treatment of Duane Retraction Syndrome and Sixth Nerve Palsy. 61
33666529 2021
6
Overminus Lens Therapy for Children With Intermittent Exotropia. 61
33662095 2021
7
[MRI study of rectus extraocular muscles in concomitant exotropia with small angle vertical deviation]. 61
33721962 2021
8
Overminus Lens Therapy for Children 3 to 10 Years of Age With Intermittent Exotropia: A Randomized Clinical Trial. 61
33662112 2021
9
Clinical factors affecting the rate of exodrift after surgery in patients with basic intermittent exotropia. 61
33753783 2021
10
Health-related quality of life in children with untreated intermittent exotropia and their parents. 61
33705917 2021
11
Effect of inferior oblique myectomy on primary position when combined with lateral rectus recession for intermittent exotropia. 61
33719623 2021
12
Change in the eye position under general anesthesia in children with intermittent exotropia. 61
33662588 2021
13
Preoperative Predictors for Esodeviation and Exodeviation after Cataract Surgery in Children. 61
33783335 2021
14
Oculomotor nerve palsy in an asymptomatic child with COVID-19. 61
33689910 2021
15
Strabismus in chronic progressive external ophthalmoplegia. 61
33191655 2021
16
A Rare Case of Congenitally Acquired Ocular Toxocariasis in A Five-Week-Old Infant. 61
33661077 2021
17
A smartphone ocular alignment measurement app in school screening for strabismus. 61
33765984 2021
18
Usefulness of virtual reality-based training to diagnose strabismus. 61
33723316 2021
19
Spectacle Decentration to Augment Over-minus Therapy in Cases with Intermittent Exotropia. 61
33577389 2021
20
Analysis of Postoperative Outcomes in Patients with Intermittent Exotropia According to Preoperative Change of Angle of Deviation. 61
33596620 2021
21
Strong fixation preference in patients with manifest exotropia: Does it matter or not? 61
33052500 2021
22
Efficacy of bilateral lateral rectus recession versus unilateral recession and resection for basic-type intermittent exotropia: a meta-analysis. 61
33576184 2021
23
Clinical Usefulness of a Computerized Vision Chart for Distance Stereoacuity Assessment in Children with Intermittent Exotropia. 61
33566722 2021
24
Predicting Risk Factors for Consecutive Esotropia Failed with Conservative Therapy. 61
33587682 2021
25
Longitudinal course of consecutive esotropia in children following surgery for basic-type intermittent exotropia. 61
33627756 2021
26
Familial neonatal nonautoimmune hyperthyroidism due to a gain-of-function (D619G) thyrotropin-receptor mutation. 61
33180037 2021
27
Strabismus After Ahmed Glaucoma Valve Implantation. 61
32818449 2021
28
Clinical features of strabismus in patients with congenital optic disc anomaly. 61
33596619 2021
29
Effect of age on reoperation rate in children undergoing exotropia surgery. 61
33529446 2021
30
Evaluation of Diplopia Secondary to Seton Implantation Surgery: Ahmed Glaucoma Valve and Diplopia. 61
33631898 2021
31
A randomized trial evaluating efficacy of overminus lenses combined with prism in the children with intermittent exotropia. 61
33549081 2021
32
Clinical and imaging features of congenital and acquired isolated inferior rectus muscle hypofunction. 61
33601045 2021
33
A novel dynamic random-dot stereopsis assessment to measure stereopsis in intermittent exotropia. 61
33708935 2021
34
Contralateral Surgery for the Treatment of Third Nerve Palsy with Aberrant Regeneration. 61
32777375 2021
35
Lateral rectus advancement versus medial rectus recession for consecutive esotropia. 61
31411047 2021
36
Outcomes of pediatric accommodative esotropia with botulinum toxin A treatment in Thailand. 61
33404269 2021
37
Unilateral lateral rectus recession is an effective surgery for intermittent exotropia in young children. 61
33407259 2021
38
Comparison of medial rectus resection and plication in exotropic patients. 61
33070271 2021
39
Medial Rectus Advancement for Secondary Exotropia. 61
32828876 2021
40
Disseminated Toxoplasmosis in a Child Following Allogeneic Hematopoietic Cell Transplantation. 61
33452804 2021
41
Surgical management of consecutive exotropia: Long-term outcomes. 61
33426920 2021
42
The influence of alternate part-time patching on control of intermittent exotropia: a randomized clinical trial. 61
33415357 2021
43
Influence of intermittent exotropia surgery on general health-related quality of life: different perception by children and parents. 61
33423137 2021
44
Comments on: Surgical management of Helveston syndrome (triad of A pattern exotropia, superior oblique overaction, and dissociated vertical deviation) using four oblique procedure. 61
33323645 2021
45
Maintenance of normal fusion in intermittent exotropia. 61
33179304 2021
46
Response to comments on: Surgical management of Helveston syndrome (triad of A pattern exotropia, superior oblique overaction and dissociated vertical deviation) using four oblique procedure. 61
33323647 2021
47
The Success of Unilateral Surgery for Constant and Intermittent Exotropia and Factors Affecting It in a Large Scandinavian Case Series. 61
33495796 2021
48
Quality of life in adult intermittent exotropia and the risk factors. 61
33747823 2021
49
Comparison of postural control between strabismic and non-strabismic children. 61
32690373 2021
50
Quantitative measurement of passive duction force tension in intermittent exotropia and its clinical implications. 61
33415355 2021

Variations for Alternating Exotropia

Expression for Alternating Exotropia

Search GEO for disease gene expression data for Alternating Exotropia.

Pathways for Alternating Exotropia

GO Terms for Alternating Exotropia

Cellular components related to Alternating Exotropia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromosome GO:0005694 9.33 MYT1L CHAMP1 BUB1B
2 chromosome, centromeric region GO:0000775 9.32 CHAMP1 BUB1B
3 kinetochore GO:0000776 9.26 CHAMP1 BUB1B
4 condensed chromosome kinetochore GO:0000777 8.96 CHAMP1 BUB1B
5 spindle GO:0005819 8.8 WDR73 CHAMP1 BUB1B

Sources for Alternating Exotropia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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