MCID: ALT003
MIFTS: 34

Alternating Exotropia

Categories: Neuronal diseases

Aliases & Classifications for Alternating Exotropia

MalaCards integrated aliases for Alternating Exotropia:

Name: Alternating Exotropia 12 15 71
Exotropia 43 71

Classifications:



External Ids:

Disease Ontology 12 DOID:1142
ICD9CM 34 378.15
MeSH 43 D005099
SNOMED-CT 67 37214009
ICD10 32 H50.15
UMLS 71 C0015310 C0152207

Summaries for Alternating Exotropia

MalaCards based summary : Alternating Exotropia, also known as exotropia, is related to monocular exotropia and esotropia. An important gene associated with Alternating Exotropia is MYT1L (Myelin Transcription Factor 1 Like), and among its related pathways/superpathways is Lysosome. The drugs Acetylcholine and Neurotransmitter Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and brain.

Related Diseases for Alternating Exotropia

Diseases related to Alternating Exotropia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 144)
# Related Disease Score Top Affiliating Genes
1 monocular exotropia 12.3
2 esotropia 11.7
3 mental retardation smith fineman myers type 11.4
4 elsahy-waters syndrome 11.2
5 focal facial dermal dysplasia 3, setleis type 11.2
6 lowry-maclean syndrome 11.2
7 miles-carpenter syndrome 11.2
8 monocular esotropia 11.0
9 suppression amblyopia 10.8
10 amblyopia 10.8
11 refractive error 10.7
12 anisometropia 10.5
13 joint laxity, short stature, and myopia 10.5
14 myopia 10.5
15 kearns-sayre syndrome 10.4
16 internuclear ophthalmoplegia 10.4
17 hypertropia 10.3
18 ptosis 10.3
19 accommodative esotropia 10.3
20 exotropia 10.3
21 astigmatism 10.3
22 duane retraction syndrome 1 10.2
23 cerebral palsy 10.2
24 hypotropia 10.2
25 abnormal retinal correspondence 10.2
26 monofixation syndrome 10.2
27 farsightedness 10.2
28 crouzon syndrome 10.1
29 hypertelorism 10.1
30 congenital ptosis 10.1
31 cycloplegia 10.1
32 basilar artery occlusion 10.1
33 cataract 10.1
34 congenital nystagmus 10.1
35 anisocoria 10.0
36 ocular dominance 10.0
37 torticollis 10.0
38 myasthenia gravis 10.0
39 retinitis pigmentosa 10.0
40 keratoconus 10.0
41 brown's tendon sheath syndrome 10.0
42 paralytic squint 10.0
43 hydrocephalus 10.0
44 duane retraction syndrome 10.0
45 ocular motility disease 10.0
46 optic nerve disease 10.0
47 eye disease 10.0
48 48,xyyy 10.0
49 isolated duane retraction syndrome 10.0
50 inflammatory myopathy with abundant macrophages 10.0

Graphical network of the top 20 diseases related to Alternating Exotropia:



Diseases related to Alternating Exotropia

Symptoms & Phenotypes for Alternating Exotropia

Drugs & Therapeutics for Alternating Exotropia

Drugs for Alternating Exotropia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
2 Neurotransmitter Agents Phase 4
3 abobotulinumtoxinA Phase 4
4 Cholinergic Agents Phase 4
5 Pharmaceutical Solutions Phase 4
6 Botulinum Toxins, Type A Phase 4
7 Botulinum Toxins Phase 4
8
Epinephrine Approved, Vet_approved Phase 2, Phase 3 51-43-4 5816
9
Racepinephrine Approved Phase 2, Phase 3 329-65-7 838
10
Bupivacaine Approved, Investigational Phase 2, Phase 3 2180-92-9, 38396-39-3 2474
11 Anesthetics Phase 2, Phase 3
12 Epinephryl borate Phase 2, Phase 3
13 Anesthetics, Local Phase 2, Phase 3
14
Nicotine Approved 54-11-5 942 89594
15
Methamphetamine Approved, Illicit 537-46-2 10836
16
Dopamine Approved 51-61-6, 62-31-7 681
17 Central Nervous System Stimulants
18 Adrenergic Agents
19 Sympathomimetics
20 Dopamine Agents
21 Mydriatics

Interventional clinical trials:

(show all 41)
# Name Status NCT ID Phase Drugs
1 Surgery Associated to Intraoperative Botulinum Toxin A for Large Angle Horizontal Strabismus: a Pilot Study Completed NCT01460355 Phase 4 Botulinum Toxin Type A;saline solution
2 Orthoptic Changes Following Photorefractive Keratectomy Completed NCT01279993 Phase 3
3 Bupivacaine Injection of Eye Muscles to Treat Strabismus Recruiting NCT01616108 Phase 2, Phase 3 Bupivacaine
4 Comparison of Medial Rectus Resection and Plication in Exotropic Patients Not yet recruiting NCT03768362 Phase 2, Phase 3
5 Randomized Study of Non-surgical Treatment Versus Observation in Asian Children With Intermittent Exotropia Terminated NCT01267500 Phase 2
6 Pilot Study of Office Based Vergence and Accommodative Therapy as Treatment of Intermittent Exotropia Unknown status NCT03321838
7 Comparison of the Changes of Lateral Rectus Muscle Insertion Measured With AS-OCT in Two Recession Surgeries Unknown status NCT02450162
8 Early Results of Slanted Recession of the Lateral Rectus Muscle for Intermittent Exotropia With Convergence Weakness; A Prospective Study Completed NCT02131792
9 Basic Intermittent Exotropia; is the Axial Length of the Globe One of the Prognostic Factors for Overcorrection and Undercorrection After Binocular Surgery Completed NCT03153423
10 Treatment for Convergence Insufficiency Intermittent Exotropia; A Randomized Trial Completed NCT01435876
11 Protective Effect of Biodegradable Collagen Implant (Ologen) in Scleral Thinning After Strabismus Surgery Completed NCT02699580
12 A Novel Dynamic Random-dot Stereopsis Assessment to Measure the Stereopsis in Intermittent Exotropia Completed NCT04152122
13 Investigation of the Effect of Oculo-Motor Exercises in Intermittent Exotropic Children Completed NCT03661476
14 A Novel Diagnostic Method for Exotropia Using Video-oculography Completed NCT03119311
15 A Pilot Randomized Clinical Trial of Overminus Spectacle Therapy for Intermittent Exotropia Completed NCT02223650
16 Strabismus Surgery and Driving Ability Completed NCT02570555
17 Pre and Post-operative Rectus Muscle Insertion Site Changing Using Anterior Segment Optical Coherence Tomography in Strabismus Patients Completed NCT02383381
18 Lateral Rectus Muscle Tendon Elongation by an Auto Graft From the Resected Medial Rectus Muscle as a Monocular Surgery for Large Angle Sensory Exotropia Completed NCT04286945
19 A Randomized Clinical Trial of Observation Versus Occlusion Therapy for Intermittent Exotropia Completed NCT01032330
20 The Flipped Classroom Approach to Teaching Horizontal Strabismus in Ophthalmology Residency: A Multi-Centered Randomized Controlled Study Completed NCT04381676
21 Assessing the Functional and Psychosocial Impact of Strabismus in Asian Children Using the AS-20 and IXTQ Questionnaires Completed NCT01608828
22 Augmented Medial Rectus Muscle Recession Versus Medial Rectus Recession With Posterior Scleral Fixation in Partially Accommodative Esotropia Completed NCT02413463
23 Bilateral Lateral Rectus Recession Using Standard Tables Versus Bilateral Lateral Rectus Recession Using Modified Reduced Numbers in Intermittent Exotropia in Children Less Than 6 Years Old Recruiting NCT04308538
24 Long-term Prospective Randomized Controlled Clinical Study on Surgical Treatment of Moderate Intermittent Exotropia Recruiting NCT02736526
25 A Clinical Trial of Observation Versus Controlled Intermittent Alternate Occlusion (CIAO) Therapy for Intermittent Exotropia Recruiting NCT02902887
26 Changes in Range of Ocular Motility Following Horizontal Rectus Muscle Surgery in Concomitant Strabismus; a Quantitate Measurements Using Lees Screen Recruiting NCT04213053
27 Slanted Bilateral Lateral Rectus Recession Versus Conventional Bilateral Lateral Rectus Recession for Convergence Insufficiency Intermittent Exotropia in Children Recruiting NCT04064112
28 Symmetrical Versus Asymmetrical Inferior Oblique Muscle Weakening Surgery for Asymmetrical Inferior Oblique Overaction Recruiting NCT03507712
29 A Phase 4 Randomized, Single-blind Study to Evaluate the Multi-media Training(SJ-RS-WL2015)Software Rehabilitating Ability of Binocular Functions in Hospitalized Adolescent Patients With Intermittent Exotropia After Eye Surgery Active, not recruiting NCT04263103
30 The Long-Term Efficacy of Overminus Lens Therapy in Intermittent Exotropia Active, not recruiting NCT03952702
31 Intermittent Exotropia Study 6: A Pilot Randomized Clinical Trial of Base-in Prism Spectacles for Intermittent Exotropia Active, not recruiting NCT03998670
32 A Randomized Clinical Trial of Overminus Spectacle Therapy for Intermittent Exotropia Active, not recruiting NCT02807350
33 A Randomized Trial of Bilateral Lateral Rectus Recession Versus Unilateral Lateral Rectus Recession With Medial Rectus Resection for Intermittent Exotropia Active, not recruiting NCT01032603
34 The Analysis of Ocular Deviations Between Dominant and Non-dominant Eye Using Video-oculography (VOG) in Intermittent Exotropia Enrolling by invitation NCT03641040
35 Effect of Strabismus Surgery on Macular and Subfoveal Choroidal Thickness Assessed by Spectral Domain Optical Coherence Tomography Enrolling by invitation NCT04285177
36 A Randomized Clinical Trial of Part-time Patching Therapy on Improvement of Deviation Control in 3 to 8 Year-old Children With Intermittent Exotropia Not yet recruiting NCT03700632
37 Improving Control of Alignment in Intermittent Esotropia Not yet recruiting NCT04199871
38 Effect of Age at Time of Surgery on the Surgical Outcome After Bilateral Lateral Rectus Muscle Recession in Intermittent Exotropia Not yet recruiting NCT04307160
39 The Effect of Light Deprivation on Visual Functions in Adult Amblyopes Not yet recruiting NCT02799836
40 LR Resection Versus Plication in Esotropia Not yet recruiting NCT04213768
41 A Clinical Trial of Observation Versus Controlled Intermittent Alternate Occlusion (CIAO) Therapy for Intermittent Exotropia Terminated NCT02466659

Search NIH Clinical Center for Alternating Exotropia

Cochrane evidence based reviews: exotropia

Genetic Tests for Alternating Exotropia

Anatomical Context for Alternating Exotropia

MalaCards organs/tissues related to Alternating Exotropia:

40
Eye, Testes, Brain, Thyroid, Cortex, Retina, Skin

Publications for Alternating Exotropia

Articles related to Alternating Exotropia:

(show top 50) (show all 2252)
# Title Authors PMID Year
1
Consecutive strabismus after infantile nystagmus syndrome surgery and potential risk factors. 61
32307586 2020
2
One-Month Postoperative Horizontal Strabismus Surgery Outcomes Using Adjustable and Nonadjustable Sutures. 61
32511075 2020
3
Effect of unilateral vertical transposition of the horizontal rectus muscles on vertical strabismus. 61
32551994 2020
4
Pseudostrabismus in the First Year of Life and the Subsequent Diagnosis of Strabismus. 61
32533950 2020
5
Analysis of the potential impact of strabismus with and without amblyopia on visual-perceptual and visual-motor skills evaluated using TVPS-3 and VMI-6 tests. 61
32535162 2020
6
Consanguineous-derived homozygous WNT1 mutation results in osteogenesis imperfect with congenital ptosis and exotropia. 61
32529806 2020
7
Difference in myopia progression between dominant and non-dominant eye in patients with intermittent exotropia. 61
32307585 2020
8
Intermittent exotropia - a potential confounding factor for full-field electroretinography. 61
32552214 2020
9
Formulas to Estimate Appropriate Surgical Amounts of Unilateral Recession-Resection in Intermittent Exotropia with Distance-Near Disparity. 61
32577021 2020
10
Risk factors for excessive postoperative exo-drift after unilateral lateral rectus muscle recession and medial rectus muscle resection for intermittent exotropia. 61
32503457 2020
11
Enhanced adjustable nasal transposition of split lateral rectus muscle for surgical management of oculomotor nerve palsy. 61
32522706 2020
12
Risk factors for spontaneous consecutive exotropia in children with refractive and nonrefractive accommodative esotropia. 61
32108919 2020
13
Comparison Between Parental Observations and Clinical Evaluation Findings in Korean Pediatric Patients With Intermittent Exotropia. 61
32453854 2020
14
Abnormal Tuning in Nucleus Prepositus Hypoglossi of Monkeys With "A" Pattern Exotropia. 61
32446250 2020
15
Congenital Zika Syndrome: Surgical and Visual Outcomes After Surgery for Infantile Strabismus. 61
32453850 2020
16
Anomalous extraocular muscles in Crouzon syndrome with V-pattern exotropia. 61
32317492 2020
17
Commentary: Anomalous extraocular muscles in Crouzon syndrome with V-pattern exotropia. 61
32317493 2020
18
Association of pseudo-exotropia with true esotropia in cicatricial retinopathy of prematurity. 61
32317477 2020
19
Evolving trends in strabismus following retinal surgery: is there still a role for botulinum toxin? 61
32396025 2020
20
Fascia lata augmented nasal transposition of split lateral rectus in complete oculomotor nerve palsy with a previous failed surgery. 61
31432693 2020
21
Surgical Outcomes of Patients with Diagnostic Preoperative Monocular Occlusion in Intermittent Exotropia. 61
32385350 2020
22
Exotropic heavy eye syndrome in unilateral high axial myopia. 61
32479997 2020
23
Inflammatory Myofibroblastic Tumor of the Orbit in an 8-Month Old. 61
31880682 2020
24
Strabismus Surgery of Consecutive Exotropia. 61
32330980 2020
25
Influence of prenatal environment and birth parameters on amblyopia, strabismus, and anisometropia. 61
32151573 2020
26
WEBINO syndrome (wall-eyed bilateral internuclear ophthalmoplegia) secondary to ischemic stroke, about a case. 61
32088083 2020
27
Prevalence of the thoracic scoliosis in children and adolescents candidates for strabismus surgery: results from a 1935-patient cross-sectional study in China. 61
32112152 2020
28
Clinical Features of Duane Retraction Syndrome: A New Classification. 61
32233150 2020
29
Clinical Manifestations of Delayed-onset Consecutive Esotropia after Surgical Correction of Intermittent Exotropia. 61
32233145 2020
30
Convergence excess consecutive esotropia associated with 0.01% atropine eye drops usage in patients operated for intermittent exotropia. 61
32174596 2020
31
The Relationship of Age and Other Baseline Factors to Outcome of Initial Surgery for Intermittent Exotropia. 61
31862447 2020
32
Motor and Sensory Outcomes of Infantile Exotropia: A 10-Year Study (2008-2017). 61
32233148 2020
33
Binocular discrepancy in lateral rectus muscle attachment in intermittent exotropia with eye dominance. 61
32314031 2020
34
The stability of horizontal ocular alignment of triad exotropia after one-step triple surgery. 61
31932885 2020
35
Central Mini-plication of the Medial Rectus for Convergence Insufficiency. 61
32167411 2020
36
Myectomy of the four horizontal rectus muscles with pulley fixation for the treatment of horizontal nystagmus in 10 adults: a pilot study. 61
32224284 2020
37
Comparison of surgical outcomes of slanted procedure for exotropia with convergence insufficiency according to their response to preoperative monocular occlusion. 61
32350350 2020
38
[Clinical research progress of intermittent exotropia]. 61
32187952 2020
39
[Morphological observation on the anterior ciliary vessels in the horizontal rectus muscles of patients with concomitant horizontal strabismus]. 61
32187948 2020
40
Topographical profiles of macula and optic nerve head in concomitant strabismus patients as measured using OCT and CSLO. 61
31754829 2020
41
A Comparative Study of Prism Adaptation and the Augmented Surgery Formula in the Management of Acquired Comitant Esotropia. 61
32203595 2020
42
Ocular alignment, media, and eyelid disorders in Down syndrome. 61
31830843 2020
43
The prevalence of tropia, phoria and their types in a student population in Iran. 61
31868064 2020
44
Comparison of surgery versus observation for small angle intermittent exotropia. 61
32170126 2020
45
Inferior oblique belly transposition for V pattern strabismus. 61
31847669 2020
46
Pseudoduplication of the optic disc initially resembling a bifurcated optic nerve in a strabismus child: a case report. 61
32169056 2020
47
Nystagmus with pendular low amplitude, high frequency components (PLAHF) in association with retinal disease. 61
31889465 2020
48
Incidence of Strabismus and Amblyopia Among Children Initially Diagnosed With Pseudostrabismus Using the Optum Data Set. 61
31730842 2020
49
Long-term outcomes following resection-recession versus plication-recession in children with intermittent exotropia. 61
31118183 2020
50
The effect of alternate occlusion on control of intermittent exotropia in children. 61
30755034 2020

Variations for Alternating Exotropia

Expression for Alternating Exotropia

Search GEO for disease gene expression data for Alternating Exotropia.

Pathways for Alternating Exotropia

Pathways related to Alternating Exotropia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.73 IDUA ATP6V0A2

GO Terms for Alternating Exotropia

Cellular components related to Alternating Exotropia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromosome, centromeric region GO:0000775 9.32 CHAMP1 BUB1B
2 kinetochore GO:0000776 9.26 CHAMP1 BUB1B
3 condensed chromosome kinetochore GO:0000777 9.16 CHAMP1 BUB1B
4 chromosome GO:0005694 9.13 MYT1L CHAMP1 BUB1B
5 spindle GO:0005819 8.8 WDR73 CHAMP1 BUB1B

Sources for Alternating Exotropia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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